Kenneth Holmes
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British scientist
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Kenneth Holmesbiology Degrees
Biology
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#1457
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Molecular Biology
#112
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#115
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Biochemistry
#472
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#555
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Chemistry Biology
Kenneth Holmes's Degrees
- Bachelors Chemistry University of Oxford
Why Is Kenneth Holmes Influential?
(Suggest an Edit or Addition)According to Wikipedia, Kenneth Charles Holmes FRS was a British molecular biologist. He was born in Hammersmith, London. He was a former colleague of Rosalind Franklin at Birkbeck College with Aaron Klug and John Finch and moved to the Laboratory of Molecular Biology, Cambridge in 1962. From 1975 and 1976 he was acting Head of Outstation, EMBL Synchrotron Radiation Laboratory at DESY, Hamburg. He worked at the Max Planck Institute for Medical Research as an "Emeritus Scientific Member".
Kenneth Holmes's Published Works
Published Works
- Atomic structure of the actin: DNase I complex (1990) (1740)
- Structure of the actin-myosin complex and its implications for muscle contraction. (1993) (1633)
- Atomic model of the actin filament (1990) (1566)
- Actin structure and function. (2011) (871)
- Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation (1989) (787)
- Structural mechanism of muscle contraction. (1999) (736)
- Refinement of the F-actin model against X-ray fiber diffraction data by the use of a directed mutation algorithm. (1993) (472)
- Induced Changes in Orientation of the Cross-Bridges of Glycerinated Insect Flight Muscle (1965) (444)
- Electron cryo-microscopy shows how strong binding of myosin to actin releases nucleotide (2003) (367)
- The molecular mechanism of muscle contraction. (2005) (359)
- Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein. (1991) (339)
- Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1 (1993) (288)
- An atomic model of the unregulated thin filament obtained by X-ray fiber diffraction on oriented actin-tropomyosin gels. (1995) (224)
- Structure of RNA and RNA binding site in tobacco mosaic virus from 4-Å map calculated from X-ray fibre diagrams (1977) (221)
- The swinging lever-arm hypothesis of muscle contraction (1997) (214)
- The actin fold (1995) (186)
- The structural basis of muscle contraction. (2000) (182)
- Synchrotron Radiation as a Source for X-ray Diffraction (1971) (173)
- X-ray diffraction evidence for α-helical coiled-coils in native muscle (1963) (168)
- Structural mechanism of the recovery stroke in the myosin molecular motor. (2005) (164)
- A comparison of muscle thin filament models obtained from electron microscopy reconstructions and low-angle X-ray fibre diagrams from non-overlap muscle. (2006) (164)
- The structure of the rigor complex and its implications for the power stroke. (2004) (143)
- Normal modes as refinement parameters for the F-actin model. (1995) (133)
- Gestalt-binding of tropomyosin to actin filaments (2008) (130)
- The shape and flexibility of tropomyosin coiled coils: implications for actin filament assembly and regulation. (2010) (118)
- Tobacco mosaic virus: application of the method of isomorphous replacement to the determination of the helical parameters and radial density distribution (1958) (118)
- The actin-myosin interface (2010) (105)
- An alternative method of solving the layer scaling equations of Hamilton, Rollett and Sparks (1966) (97)
- The actomyosin interaction and its control by tropomyosin. (1995) (93)
- The use of x-ray diffraction in the study of protein and nucleic acid structure. (1965) (84)
- Internal motions in myosin. (1979) (84)
- Interpretation of the low angle X-ray diffraction from insect flight muscle in rigor (1980) (83)
- Unusual segmental flexibility in a region of tobacco mosaic virus coat protein (1978) (81)
- Role of the salt-bridge between switch-1 and switch-2 of Dictyostelium myosin. (1999) (79)
- Structural evidence that myosin heads may interact with two sites on F-actin (1982) (79)
- A new ATP-binding fold in actin, hexokinase and Hsc70. (1993) (78)
- Cross-bridge conformation as revealed by x-ray diffraction studies on insect flight muscles with ATP analogues. (1975) (78)
- Structure of tobacco mosaic virus at 6.7 Å resolution (1975) (77)
- Muscle proteins--their actions and interactions. (1996) (76)
- Cross-bridges and the mechanism of muscle contraction. (1983) (67)
- Constancy of Axial Spacings in Frog Sartorius Muscle during Contraction (1965) (65)
- Methods of preparing orientated tobacco mosaic virus sols for X-ray diffraction (1965) (63)
- Studies on the structure of parasporal inclusions from Bacillus thuringiensis. (1965) (61)
- Muscle proteins: actin (1991) (57)
- Crystallization of Transfer RNA (1968) (56)
- Structure of dahlemense strain of tobacco mosaic virus: a periodically deformed helix. (1969) (53)
- Structural modeling and molecular dynamics simulation of the actin filament (2011) (47)
- X-ray diffraction studies on ribosomes from various sources. (1961) (46)
- Effects of ATP analogs on the low-angle X-ray diffraction Pattern of insect flight muscle (1973) (45)
- Structural biology: Actin in a twist (2009) (42)
- Binding of myosin subfragment 1 to glycerinated insect flight muscle in the rigor state. (1985) (39)
- The radial density distribution in some strains of tobacco mosaic virus. (1958) (38)
- x-ray diffraction studies of muscle. (1981) (36)
- A new helical aggregate of tobacco mosaic virus protein. (1976) (35)
- The effect of disorientation on the intensity distribution of non‐crystalline fibres. I. Theory (1974) (33)
- Identification of the transitory complex myosin-ATP by the use of , -methylene-ATP. (1973) (31)
- X-ray diffraction studies of concentrated gels of ribosomes from E. coli. (1962) (31)
- How X-ray Diffraction with Synchrotron Radiation Got Started. (1998) (29)
- The myosin start‐of‐power stroke state and how actin binding drives the power stroke (2013) (28)
- Crystallization of yeast phenylalanine transfer ribonucleic acid. (1970) (28)
- Protein-RNA interactions during TMV assembly. (1979) (27)
- Reversal of Interlaminar Signal Between Sensory and Memory Processing in Monkey Temporal Cortex (2011) (27)
- Curvature variation along the tropomyosin molecule. (2010) (26)
- Structural Studies of Viruses (1967) (26)
- X-ray diffraction studies of the structure and morphology of tobacco mosaic virus (1957) (26)
- A comparison of the atomic model of F-actin with cryo-electron micrographs of actin and decorated actin. (1993) (25)
- The helical arrangement of the protein subunits in tobacco mosaic virus. (1956) (23)
- Development of Synchrotron Radiation as a High-Intensity Source for X-ray Diffraction. (1997) (23)
- X-ray diffraction evidence for alpha-helical coiled-coils in native muscle. (1963) (21)
- An electron-density map of tobacco mosaic virus at 10 Å resolution (1972) (21)
- Protein-RNA interactions during the assembly of tobacco mosaic virus (1980) (20)
- Molecular Mechanisms in Muscular Contraction (1990) (20)
- An analysis of the structure of insect flight muscle in rigor and in the presence of ATP (β, γ−NH) (1980) (18)
- X-ray diffraction studies on muscle regulation. (1991) (18)
- The positions of the N-terminus and residue 68 in tobacco mosaic virus. (1974) (16)
- A molecular model for muscle contraction. (1998) (16)
- On the structure of some ribonucleoprotein particles (1958) (14)
- X-ray diffraction studies on oriented gels of vertebrate smooth muscle thin filaments. (1992) (14)
- Small−angle diffraction of X−rays and the study of biological structures (1980) (13)
- Towards a molecular mechanism for the crossbridge cycle. (1988) (13)
- The structure of S1-decorated actin filaments calculated from x-ray diffraction data with phases derived from electron micrographs. (1982) (13)
- A powerful stroke (1998) (13)
- Control of the Actomyosin Interaction. (1995) (13)
- 50 years of fiber diffraction. (2010) (12)
- The interpretation of X-ray diffraction from glycerinated flight muscle fibre bundles: new theoretical and experimental approaches (1977) (12)
- The myosin cross−bridge as revealed by structure studies (1977) (12)
- An investigation of the cross-bridge cycle using ATP analogues and low-angle X-ray diffraction from glycerinated fibres of insect flight muscle (1976) (11)
- Flexibility in tobacco mosaic virus. (1983) (11)
- Solving the structures of macromolecular complexes. (1994) (10)
- The Molecular Mechanism of Muscle Contraction (2000) (9)
- The actin-binding cleft: functional characterisation of myosin II with a strut mutation (2006) (9)
- The use of some novel X-ray diffraction techniques to study the effect of nucleotides on cross-bridges in insect flight muscle (1979) (8)
- Switch 1 opens on strong binding to actin (2003) (8)
- Steric blocking mechanism explains stretch activation in insect flight muscle (2010) (8)
- New books - The use of X-ray diffraction in the study of protein and nucleic acid structure (1966) (8)
- Introduction: one contribution of 14 to a discussion meeting issue 'Myosin, muscle and motility' (2004) (8)
- The attachment of a complex uranylfluoride to tobacco mosaic virus. (1963) (7)
- Advances in Structural Biology and the Application to Biological Filament Systems (2018) (7)
- Solving the structure of macromolecular complexes with the help of X-ray fiber diffraction diagrams. (1995) (7)
- Computer processing and analysis of X‐ray fibre diffraction data (1993) (6)
- The molecular basis of cross-bridge function. (2005) (6)
- Aaron Klug - A Long Way from Durban: A Biography (2017) (6)
- Switch 1 opens on strong binding to actin. Molecular and cellular aspects of muscle contraction. (2003) (6)
- The nature of the actin cross-bridge interaction. (1984) (6)
- Synchrotron radiation as a source for X-ray diffraction the beginning (1989) (5)
- The structure and assembly of simple viruses (1982) (5)
- The structure determination of tobacco mosaic virus (1984) (5)
- The structure of F−actin calculated from X−ray fibre diagrams and the 0.6nm crystal structure (1989) (5)
- The determination of the heavy atom positions in tobacco mosaic virus from double heavy atom derivatives (1972) (5)
- Sir John Cowdery Kendrew. 24 March 1917 – 23 August 1997 (2001) (4)
- The life of a sage (2006) (4)
- Insight into biosynthesis of human urokinase forms (1985) (4)
- The design requirements of vertebrate striated muscle (1966) (4)
- A Comparison of Actin Filament Models by Molecular Dynamics Simulation (2010) (3)
- Obituary: Carl-Ivar Brändén (1934–2004) (2004) (3)
- 31P NMR studies on ATP.Mg2+p21−nucleotide complexes. Chemical shifts, rate and equilibrium constants (1986) (3)
- CONFERENCE REPORT: Summarized proceedings of a conference on biological structures and computational methods - London, November 1956 (1958) (3)
- Application of synchrotron radiation in biology (1974) (3)
- From rare to routine (1998) (2)
- 31P-NMR studies on ATP X Mg2+, p21 X nucleotide, and adenylate kinase X nucleotide complexes. Chemical shifts, rate and equilibrium constants. (1986) (2)
- Cryo-electron microscopy of vitrified muscle samples. (1992) (2)
- Aaron Klug (1926-2018) (2018) (2)
- MÖSSBAUER SPECTRA OF I129 IN TOBACCO MOSAIC VIRUS (1976) (1)
- Structure and assembly of tobacco mosaic virus (1978) (1)
- Multivariate Statistical Analysis and Tomographic Processing of Helical Objects (2002) (1)
- The isomorphous replacement method (1965) (1)
- Aaron Klug—Nobel Price for Chemistry (1983) (1)
- The Myosin Start-of-Power Stroke State and How Actin Binding Drives the Power Stroke (2014) (1)
- Zero−loss P−contrast in EFTEM (1998) (1)
- Hugh Esmor Huxley (1924–2013) (2013) (1)
- Obituary: John Cowdery Kendrew (1917-97) (1997) (1)
- Image Formation from Frozen Hydrated Samples in an Energy-Filter-Microscope (1997) (1)
- The Laboratory of Molecular Biology (2017) (1)
- Picture story. A powerful stroke. (1998) (1)
- Determination of Tilt Parameters in Electron Diffraction Patterns of 3D-Microcrystals (1997) (1)
- A group-refinement program applied to the structure of myoglobin (1963) (1)
- An electron-density map of tobacco mosaic virus at 10 Angstrom resolution. (1972) (1)
- X-Ray diffraction studies on tobacco mosaic virus and related substances. (1959) (1)
- The molecular basis of muscle contraction. (1983) (1)
- Structure of tobacco mosaic virus: a 10 Å resolution projection through the subunit (1963) (0)
- The structure of the actin filament: comparison of the X−ray diffraction structure with cryoelectron miscroscopy (1991) (0)
- A modified theory of image formation in an EFTEM (1998) (0)
- Synchrotron radiation as an X-ray source: An overview (1986) (0)
- Variations of helical parameters in reconstituted TMV coat protein (1973) (0)
- Durban and Johannesburg (2017) (0)
- Proceedings: The cross-bridge cycle in insect flight muscle as revealed by the use of ATP analogues and X-ray diffraction. (1975) (0)
- Dynamics of biomolecules investigated by X−ray diffraction (1997) (0)
- Myosin Polymorphism and Muscle Contraction (2004) (0)
- MBE . 25 February 1924 (2017) (0)
- Supplementary material from "JOHN THOMAS FINCH. 28 February 1930 — 5 December 2017" (2018) (0)
- Electron-diffraction patterns from hydrated protein microcrystals: a new tool in structural biology (1994) (0)
- A 10A resolution electron density map of TMV using a semiautomatic data processing system (1972) (0)
- X−ray diffraction in biology (1973) (0)
- Image Analysis in Electron Microscopy (2017) (0)
- Back to Cambridge (2017) (0)
- Aaron Klug's Scientific Publications (2017) (0)
- The Rigor Structure of Acto-Myosin and Its Implications for Motor Function (2002) (0)
- Spherical Virus Structure (2017) (0)
- Rosalind Franklin and the Tobacco Mosaic Virus (2003) (0)
- Driven to diffraction (2004) (0)
- Aaron's Birthplace: Zelva, Lithuania, by Mark Gevisser (2017) (0)
- Synchrotron radiation as a tool in muscle physiology (1982) (0)
- Tobacco Mosaic Virus (2017) (0)
- Structural biology (2008) (0)
- Multivariate statistical analysis (MSA) improves azimuthal alignment along the axis of helical objects and results in higher resolution for reconstruction using a single particle approach (2002) (0)
- Electron−Diffraction Patterns from Hydrated Protein Microcrystals (1994) (0)
- [Identification of a 2nd myosine configuration using ATP analogues]. (1972) (0)
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences: 359 (1452) (2004) (0)
- Measuring motions in muscles (1999) (0)
- Crystallographers' proteins (1986) (0)
- Director of the Laboratory of Molecular Biology (2017) (0)
- Generation of a functional myosin motor by inversion of a salt bridge between the N2 and N3 motifs (1999) (0)
- Vibrational modes of G-actin. (1994) (0)
- X-ray diffraction pattern of doughs from strong and weak flours (1962) (0)
- Molecular Dynamics of Tropomyosin: Implications for the Assembly and Regulation of Thin Filaments (2009) (0)
- New dynamic and structural dynamic investigations on insect flight muscle (1982) (0)
- The Structural Biology of Muscle: Spatial and Temporal Aspects (2012) (0)
- X-ray diffraction studies on tobacco mosaic virus; an electron density map at 10A resolution (1970) (0)
- Master's thesis recital (viola) (2018) (0)
- From Durban to Birkbeck College (2017) (0)
- The interpretation of X−ray diffraction from glycerinated flight muscle (1977) (0)
- A hydrogen bond study in tobacco mosaic virus using Moessbauer spectroscopy (2004) (0)
- Chromatin and Nucleosomes (2017) (0)
- The use of sychrotron radiation as a source for x-ray diffraction (1978) (0)
- Emerging Techniques: Synchrotron Radiation (1976) (0)
- Chapter 14 - Image quality (2009) (0)
- Hugh Esmor Huxley MBE. 25 February 1924 — 25 July 2013 (2017) (0)
- Abstracts of the XVIII European Conference on Muscle and Motility (1990) (0)
- X-Ray crystallographic studies of phenylalanine t-RNA from yeast (1970) (0)
- Presidency of the Royal Society (2017) (0)
- John Thomas Finch. 28 February 1930—5 December 2017 (2019) (0)
- Synchrotron radiation and its applications in biology. (1974) (0)
- X-Ray diffraction studies on tobacco mosaic virus; an electron density map at 10 A Resolution. (1970) (0)
- Picture story. Measuring motions in muscles. (1999) (0)
- Understanding muscle contraction by combining crystallography, cryo-EM and fibre diffraction (1996) (0)
- The Use of Filter Cryo-Electron Microscopy to Reveal Details of the Actomyosin Interaction (1995) (0)
- Structure studies on repolymerized TMV protein (1973) (0)
- The First Visit to Israel (2017) (0)
- From Thon Rings to Modern Dance (2017) (0)
- Cryo electron microscopy shows that myosin switch 1 opens on strong binding to actin (2002) (0)
- Molecular Structure of the Actomyosin System in Cross-striated Muscle (1972) (0)
- Muscle Contraction (1998) (0)
- Hugh Esmor Huxley (1924–2013) (2013) (0)
- Supplementary material from "Hugh Esmor Huxley MBE. 25 February 1924 — 25 July 2013" (2017) (0)
- Sixth International Biophysics Congress (1977) (0)
- Reconstruction of the acto‐myosin interface: new approaches and new results (1999) (0)
- Doctoral thesis recital (viola) (2019) (0)
- Refinement of the F-actin structure against fiber diffraction data (1996) (0)
- [The self-organization of biological structures (author's transl)]. (1975) (0)
- 7th Biophysical Discussions. Molecular motors: structure, mechanics and energy transduction. Proceedings of a meeting. (1995) (0)
- The Actomyosin Interaction (1995) (0)
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