Klaus Rajewsky | Academic Influence

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Klaus Rajewsky

Biology

#506

World Rank

#889

Historical Rank

Immunology

#18

World Rank

#21

Historical Rank

biology Degrees

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Biology

Klaus Rajewsky's Degrees

PhD Biology University of Cologne

Why Is Klaus Rajewsky Influential?

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According to Wikipedia, Klaus Rajewsky is a German immunologist, renowned for his work on B cells. He studied medicine in Frankfurt, Munich and at the Pasteur Institute, Paris. In 1964 he started working at the Institute of Genetics in the University of Cologne, where he became professor for genetics. He researched Hodgkin's disease and the role of B cells within the immune system. He also developed conditional knockout mice based on Cre-Lox recombination.

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Klaus Rajewsky's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Interleukin-10-deficient mice develop chronic enterocolitis (1993) (4399)
Inducible gene targeting in mice (1995) (1952)
A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene (1991) (1901)
Clonal selection and learning in the antibody system (1996) (1805)
A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. (1979) (1776)
Regulation of the Germinal Center Response by MicroRNA-155 (2007) (1553)
Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. (1994) (1470)
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. (2005) (1350)
Generation and analysis of interleukin-4 deficient mice. (1991) (1314)
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. (1995) (1287)
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes (2008) (1279)
In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death (1997) (1209)
Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells (1998) (1208)
Intraclonal generation of antibody mutants in germinal centres (1991) (1121)
Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning (1994) (1025)
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting (1993) (1011)
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells (2015) (1011)
Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells (2006) (983)
Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction (2000) (940)
Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. (1995) (927)
MicroRNA Control in the Immune System: Basic Principles (2009) (869)
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1 (2003) (863)
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. (2009) (792)
B lymphocyte-specific, Cre-mediated mutagenesis in mice. (1997) (758)
Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells (1996) (740)
Cellular origin of human B-cell lymphomas. (1999) (730)
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination (2006) (727)
Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice (1995) (724)
From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. (1999) (721)
Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress (1999) (704)
Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. (1993) (701)
Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. (1994) (663)
Aberrant T cell differentiation in the absence of Dicer (2005) (656)
Requirement of mammalian DNA polymerase-β in base-excision repair (1996) (632)
PI3 Kinase Signals BCR-Dependent Mature B Cell Survival (2009) (622)
Dicer Ablation Affects Antibody Diversity and Cell Survival in the B Lymphocyte Lineage (2008) (617)
IgH class switching and translocations use a robust non-classical end-joining pathway (2007) (605)
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region (1981) (603)
B cell receptor signal strength determines B cell fate (2004) (574)
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. (1995) (573)
MHC class I expression in mice lacking the proteasome subunit LMP-7. (1994) (555)
A critical role of λ5 protein in B cell development (1992) (553)
Critical role for β7 integrins in formation of the gut-associated lymphoid tissue (1996) (540)
BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. (1998) (528)
Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer (2004) (527)
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. (2008) (498)
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2 (2002) (495)
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice (2011) (483)
A role for CD5 in TCR-mediated signal transduction and thymocyte selection. (1995) (477)
MicroRNA profiling of the murine hematopoietic system (2005) (471)
Most peripheral B cells in mice are ligand selected (1991) (466)
Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav (1995) (440)
Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion (1992) (423)
The half‐lives of serum immunoglobulins in adult mice (1988) (421)
Induction of T and B cell immunity by anti‐idiotypic antibody (1975) (418)
Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. (2003) (410)
Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. (1997) (408)
Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B‐CLL progenitor generation. (1990) (405)
Vagaries of conditional gene targeting (2007) (403)
THE REQUIREMENT OF MORE THAN ONE ANTIGENIC DETERMINANT FOR IMMUNOGENICITY (1969) (396)
NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti (2000) (396)
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. (2001) (393)
FOXO1 couples metabolic activity and growth state in the vascular endothelium (2015) (393)
MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb (2007) (383)
Evolutionary and somatic selection of the antibody repertoire in the mouse. (1987) (380)
TNF Family Member B Cell-Activating Factor (BAFF) Receptor-Dependent and -Independent Roles for BAFF in B Cell Physiology1 (2004) (375)
Ku80 is required for immunoglobulin isotype switching (1998) (367)
Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: A tool for efficient genetic engineering of mammalian genomes (2002) (367)
Memory B-cell persistence is independent of persisting immunizing antigen (2000) (363)
Shutdown of class switch recombination by deletion of a switch region control element (1993) (354)
Evidence for a large compartment of IgM-expressing memory B cells in humans. (1997) (354)
Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. (2004) (354)
Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. (2006) (353)
MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb (2007) (352)
Somatic hypermutation in normal and transformed human B cells (1998) (349)
Maintenance of B-cell memory by long-lived cells generated from proliferating precursors (1990) (347)
Homeostasis of Peripheral B Cells in the Absence of B Cell Influx from the Bone Marrow (2001) (338)
Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex (1996) (337)
The Toll-like Receptor Protein Rp105 Regulates Lipopolysaccharide Signaling in B Cells (2000) (336)
Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development (1993) (335)
Mature Follicular Dendritic Cell Networks Depend on Expression of Lymphotoxin β Receptor by Radioresistant Stromal Cells and of Lymphotoxin β and Tumor Necrosis Factor by B Cells (1999) (333)
Conditional gene targeting. (1996) (329)
Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching (1998) (329)
Regulation of microRNA expression and abundance during lymphopoiesis. (2010) (328)
Expansion and functional activity of Ly‐1+ B cells upon transfer of peritoneal cells into allotype‐congenic, newborn mice (1987) (327)
Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. (2004) (327)
Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. (2003) (324)
Rapid generation of inducible mouse mutants. (2003) (316)
Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. (1997) (312)
T Cell–specific Inactivation of the Interleukin 10 Gene in Mice Results in Enhanced T Cell Responses but Normal Innate Responses to Lipopolysaccharide or Skin Irritation (2004) (310)
The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease. (1998) (309)
Analysis of the repertoire of anti‐NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response (1978) (297)
PCR-based cDNA library construction: general cDNA libraries at the level of a few cells. (1989) (285)
MYC is essential for the formation and maintenance of germinal centers (2012) (284)
Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1 (2008) (282)
BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma. (2010) (279)
Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. (2012) (278)
Somatic hypermutation in the heavy chain locus correlates with transcription. (1998) (277)
Clonal Deleterious Mutations in the Iκbα Gene in the Malignant Cells in Hodgkin's Lymphoma (2000) (274)
Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways. (1989) (273)
Antibody engineering for the analysis of affinity maturation of an anti‐hapten response. (1988) (268)
The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow. (1990) (266)
Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells. (1997) (264)
Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma. (1999) (262)
Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses (1995) (257)
Yin Yang 1 is a critical regulator of B-cell development. (2007) (255)
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. (2004) (254)
V(D)J recombination in mature B cells: a mechanism for altering antibody responses. (1997) (253)
The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia. (2010) (253)
B cell development under the condition of allelic inclusion. (1997) (251)
B Cell Antigen Receptor Specificity and Surface Density Together Determine B-1 versus B-2 Cell Development (1999) (248)
EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B cell compartment and establishing latency. (2000) (246)
Requirement of mammalian DNA polymerase-beta in base-excision repair. (1996) (246)
Analysis of the B-cell progenitor compartment at the level of single cells (1994) (244)
B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity. (2007) (244)
Genetics, expression, and function of idiotypes. (1983) (241)
Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells (1993) (239)
Modeling the Initiation and Progression of Human Acute Leukemia in Mice (236)
Analysis of the repertoire of anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti‐idiotope antibodies (1979) (234)
Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP. (1986) (233)
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma (2015) (232)
Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. (1996) (230)
Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses (1987) (227)
Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory (2012) (227)
Postnatally Induced Inactivation of gp130 in Mice Results in Neurological, Cardiac, Hematopoietic, Immunological, Hepatic, and Pulmonary Defects (1998) (226)
Timing, Genetic Requirements and Functional Consequences of Somatic Hypermutation during B‐Cell Development (1987) (225)
Stringent doxycycline dependent control of CRE recombinase in vivo. (2002) (225)
Mature T cells depend on signaling through the IKK complex. (2003) (222)
B cell development regulated by gene rearrangement: Arrest of maturation by membrane-bound Dμ protein and selection of DH element reading frames (1991) (222)
Activation of mouse complement by monoclonal mouse antibodies (1981) (219)
Rare Occurrence of Classical Hodgkin's Disease as a T Cell Lymphoma (2000) (219)
The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response (1990) (218)
Novel Reporter Mouse Reveals Constitutive and Inflammatory Expression of IFN-β In Vivo1 (2009) (209)
DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation. (2000) (207)
Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. (2008) (207)
IκB Kinase Signaling Is Essential for Maintenance of Mature B Cells (2002) (204)
MicroRNA control in the immune system: basic principles. (2009) (204)
Critical functions for c-Myb at three checkpoints during thymocyte development (2004) (199)
Somatic Mutation of the Cd95 Gene in Human B Cells as a Side-Effect of the Germinal Center Reaction (2000) (198)
PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones. (2015) (192)
Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. (2006) (191)
High-Resolution Description of Antibody Heavy-Chain Repertoires in Humans (2011) (190)
Temporally and spatially regulated somatic mutagenesis in mice. (1998) (187)
Structure of primary anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice (1985) (186)
Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. (1996) (186)
c-Myb is critical for B cell development and maintenance of follicular B cells. (2005) (186)
Antigen receptors of T helper cells. (1977) (181)
Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes (2016) (180)
Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma. (2010) (180)
Disruption of the Rev3l-encoded catalytic subunit of polymerase ζ in mice results in early embryonic lethality (2000) (179)
A novel 34‐kd protein co‐isolated with the IgM molecule in surface IgM‐expressing cells. (1988) (178)
NEMO/IKK gamma-deficient mice model incontinentia pigmenti. (2000) (175)
Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express Vϰ genes with no or little somatic mutation throughout life (1993) (175)
Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells (1994) (174)
Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin/Reed-Sternberg cells of a Hodgkin's lymphoma patient. (1996) (173)
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. (2005) (172)
Developmental and functional impairment of T cells in mice lacking CD3 zeta chains. (1993) (170)
Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells (2005) (165)
Stepwise intraclonal maturation of antibody affinity through somatic hypermutation. (1988) (164)
The Lingering Enigma of the Allelic Exclusion Mechanism (2004) (164)
Gene targeting in the Ig kappa locus: efficient generation of lambda chain‐expressing B cells, independent of gene rearrangements in Ig kappa. (1993) (163)
Hybrid cell lines secreting monoclonal antibody specific for major histocompatibility antigens of the mouse (1978) (163)
TET proteins and 5‐methylcytosine oxidation in hematological cancers (2015) (161)
Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans. (1993) (160)
Bypass of lethality with mosaic mice generated by Cre–loxP-mediated recombination (1996) (160)
Idiotypic analysis of the response of C57BL/6 mice to the (4‐hydroxy‐3‐nitrophenyl)acetyl group (1977) (159)
Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression (1997) (156)
A critical role of lambda 5 protein in B cell development. (1992) (152)
Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse. (1989) (152)
A Prematurely Expressed Igκ Transgene, but Not a VκJκ Gene Segment Targeted into the Igκ Locus, Can Rescue B Cell Development in λ5-Deficient Mice (1996) (152)
DNA polymerase κ deficiency does not affect somatic hypermutation in mice (2002) (147)
T Cell–specific Ablation of Fas Leads to Fas Ligand–mediated Lymphocyte Depletion and Inflammatory Pulmonary Fibrosis (2004) (147)
Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-κB pathway and promotes lymphomagenesis (2008) (145)
Epstein–Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction (2003) (145)
Development and proliferation of lymphocytes in mice deficient for both interleukins‐2 and ‐4 (1994) (143)
Early B‐Cell Development in the Mouse: Insights from Mutations Introduced by Gene Targeting (1994) (143)
Recognition of idiotypes in lymphocyte interactions II. Antigen‐independent cooperation between T and B lymphocytes that possess similar and complementary idiotypes (1978) (142)
Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers. (1994) (141)
The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival (2005) (141)
Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment. (1988) (140)
Mechanisms promoting translocations in editing and switching peripheral B cells (2009) (140)
Requirement of mammalian DNA polymerase-β in base-excision repair (1996) (139)
Contribution of Receptor Editing to the Antibody Repertoire (2001) (137)
Hodgkin and Reed-Sternberg-like cells in B-cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B-cell-derived clones: potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease. (2000) (134)
Somatic mutation and clonal expansion of B cells in an antigen‐driven immune response. (1985) (134)
How alpha beta T cells deal with induced TCR alpha ablation. (2001) (133)
Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice (1998) (133)
Interference with Immunoglobulin (Ig)α Immunoreceptor Tyrosine–Based Activation Motif (Itam) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Igβ Cytoplasmic Tail (2001) (132)
Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus. (1993) (130)
The Roles of γ1 Heavy Chain Membrane Expression and Cytoplasmic Tail in IgG1 Responses (1997) (128)
Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model (2012) (127)
Activation of Stat3 signaling in AgRP neurons promotes locomotor activity. (2008) (127)
B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens (1994) (125)
Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell‐dependent antigen (1992) (125)
How αβ T cells deal with induced TCRα ablation (2001) (125)
B Cell Development Is Arrested at the Immature B Cell Stage in Mice Carrying a Mutation in the Cytoplasmic Domain of Immunoglobulin β (2001) (125)
FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. (2006) (124)
MicroRNA‐17∼92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways (2013) (123)
IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Igα/β (2007) (123)
Detection of clonal B cell populations in paraffin-embedded tissues by polymerase chain reaction. (1993) (119)
Generation of memory B cells inside and outside germinal centers (2014) (118)
VH‐gene expression in murine lipopolysaccharide blasts distributes over the nine known VH‐gene groups and may be random (1985) (117)
Idiotypic analysis of lymphocytes in vitro. I. Specificity and heterogeneity of B and T lymphocytes reactive with anti-idiotypic antibody (1976) (116)
Survival and Clonal Expansion of Mutating “Forbidden” (Immunoglobulin Receptor–Deficient) Epstein-Barr Virus–Infected B Cells in Angioimmunoblastic T Cell Lymphoma (2001) (115)
LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1. (2008) (114)
Immunological memory: lessons from the past and a look to the future (2016) (113)
Control of Idiotope Expression by Monoclonal Anti‐Idiotope Antibodies (1980) (112)
NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells (2008) (112)
Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells. (2000) (111)
Burkitt’s Lymphoma Is a Malignancy of Mature B Cells Expressing Somatically Mutated V Region Genes (1995) (111)
Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies (1994) (109)
Somatic variants of murine immunoglobulin λ light chains (1982) (109)
Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling. (2006) (109)
The Molecular Mechanism of B Cell Activation by toll-like Receptor Protein RP-105 (1998) (107)
miR-23∼27∼24 clusters control effector T cell differentiation and function (2016) (107)
Persistence of memory B cells in mice deprived of T cell help. (1990) (106)
Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human (2001) (105)
Immunity to viruses in B cell‐deficient mice: Influence of antibodies on virus persistence and on T cell memory (1996) (105)
Common Germinal-Center B-Cell Origin of the Malignant Cells in Two Composite Lymphomas, Involving Classical Hodgkin’s Disease and Either Follicular Lymphoma or B-CLL (2001) (102)
Lymphocyte populations and immune responses in CD5‐deficient mice (1994) (102)
Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. (2011) (101)
Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine (2014) (100)
Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally. (2000) (99)
Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination (2011) (99)
Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice. (1996) (98)
B cell deletion, anergy, and receptor editing in "knock in" mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain. (1998) (98)
Variable region gene analysis of B cell subsets derived from a 4-year- old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age (1994) (96)
Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts. (1986) (96)
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells (2008) (96)
Molecular analysis of single B cells from T-cell-rich B-cell lymphoma shows the derivation of the tumor cells from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells. (1999) (96)
Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line (2016) (95)
Generation of mice with a conditional Foxp2 null allele (2007) (95)
Follicular Dendritic Cell-Specific Prion Protein (PrPc) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen (2011) (93)
Biology of Hodgkin's lymphoma. (2002) (92)
Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance (2004) (92)
Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse (1996) (92)
Regulation of the antibody response against hapten-coupled erythrocytes by monoclonal antihapten antibodies of various isotypes. (1982) (91)
Isolated hapten‐binding receptors of sensitized lymphocytes I. Receptors from nylon wool‐enriched mouse T lymphocyte lack serological markers of immunoglobulin constant domain but express heavy chain variable portions (1977) (91)
Rearrangement and Expression of Immunoglobulin Light Chain Genes Can Precede Heavy Chain Expression during Normal B Cell Development in Mice (1999) (91)
On the structure of the T-cell receptor for antigen. (1977) (90)
The B-Cell-Specific src-Family Kinase Blk Is Dispensable for B-Cell Development and Activation (2000) (89)
Evidence for surface‐associated immunoglobulin on T and B lymphocytes (1971) (89)
T Cell–Derived IL-17 Mediates Epithelial Changes in the Airway and Drives Pulmonary Neutrophilia (2013) (88)
Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production (2006) (88)
Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching (2008) (87)
IKKβ/2 induces TWEAK and apoptosis in mammary epithelial cells (2006) (86)
Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's disease. (1999) (84)
Recombination between antibody heavy chain variable-region genes: evidence for gene conversion. (1983) (82)
L‐selectin and β7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes (1998) (82)
Tissue-specific DNA demethylation is required for proper B-cell differentiation and function (2016) (82)
Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity. (2012) (82)
Ir‐LDHB: Map position and functional analysis (1973) (81)
Idiotypic analysis of lymphocytes in vitro. II. Genetic control of T- helper cell responsiveness to anti-idiotypic antibody (1976) (81)
Idiotypic regulation by isologous monoclonal anti-idiotope antibodies (1981) (81)
The origin of CD95-gene mutations in B-cell lymphoma. (2002) (80)
Efficiency of RNA Interference in the Mouse Hematopoietic System Varies between Cell Types and Developmental Stages (2005) (79)
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination (2014) (79)
STAT3 Activation in Th17 and Th22 Cells Controls IL-22–Mediated Epithelial Host Defense during Infectious Colitis (2014) (78)
miR-155 regulates HGAL expression and increases lymphoma cell motility. (2012) (77)
New variants of inducible Cre recombinase: a novel mutant of Cre-PR fusion protein exhibits enhanced sensitivity and an expanded range of inducibility. (2001) (77)
Unidirectional Cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71. (2003) (76)
Rearrangement of upstream DH and VH genes to a rearranged immunoglobulin variable region gene inserted into the DQ52‐JH region of the immunoglobulin heavy chain locus (1995) (76)
Isolation of variants of mouse myeloma X63 that express changed immunoglobulin class. (1980) (75)
THE IMMUNE RESPONSE TO A HYBRID PROTEIN MOLECULE (1967) (75)
Failure of HY-specific thymocytes to escape negative selection by receptor editing. (2002) (75)
The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses. (1997) (75)
Effective Destruction of Fas-deficient Insulin-producing β Cells in Type 1 Diabetes (2003) (74)
Tolerance Specificity and the Immune Response to Lactic Dehydrogenase Isoenzymes (1967) (74)
B cells of chronic lymphatic leukemia express V genes in unmutated form. (1991) (74)
Inhibition of NF-κ B activation in macrophages increases atherosclerosis in LDL receptor – deficient mice (2003) (73)
Natural occurrence and origin of somatically mutated memory B cells in mice (1992) (73)
Ablation of thymic export causes accelerated decay of naïve CD4 T cells in the periphery because of activation by environmental antigen (2008) (73)
Antiviral Protection and Germinal Center Formation, But Impaired B Cell Memory in the Absence of CD19 (1998) (73)
Secondary V(D)J recombination in B-1 cells (1999) (72)
sgRNA Sequence Motifs Blocking Efficient CRISPR/Cas9-Mediated Gene Editing (2019) (72)
Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. (1998) (72)
Lambda chain expression at different stages of ontogeny in C57BL/6, BALB/c and SJL mice (1981) (72)
Rearrangement-Enhancing Element Upstream of the Mouse Immunoglobulin Kappa Chain J Cluster (1996) (71)
Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo. (1998) (71)
Development of immunoglobulin λ-chain–positive B cells, but not editing of immunoglobulin κ-chain, depends on NF-κB signals (2009) (70)
Control of idiotope expression by monoclonal anti‐idiotope and idiotope‐bearing antibody (1981) (70)
An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression. (2015) (69)
Redundancy in Tumor Necrosis Factor (TNF) and Lymphotoxin (LT) Signaling In Vivo: Mice with Inactivation of the Entire TNF/LT Locus versus Single-Knockout Mice (2002) (69)
Ig-α Cytoplasmic Truncation Renders Immature B Cells More Sensitive to Antigen Contact (1999) (69)
Monoclonal antibodies against murine cell surface antigens: anti-H-2, anti-Ia and anti-T cell antibodies. (1978) (69)
Polζ ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability (2009) (68)
Profiling of Hodgkin’s Lymphoma Cell Line L1236 and Germinal Center B Cells: Identification of Hodgkin’s Lymphoma-specific Genes (2003) (68)
Isolation of immunoglobulin class switch variants from hybridoma lines secreting anti-idiotope antibodies by sequential sublining. (1983) (66)
PLC-γ2 is essential for formation and maintenance of memory B cells (2009) (66)
Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes. (2000) (66)
The immune response against anti‐idiotope antibodies. I. Induction of idiotope‐bearing antibodies and analysis of the idiotope repertoire (1982) (65)
V gene rearrangement is required to fully activate the hypermutation mechanism in B cells. (1989) (65)
Incomplete block of B cell development and immunoglobulin production in mice carrying the μ MT mutation on the BALB/c background (2002) (65)
Clonality and germinal centre B-cell derivation of Hodgkin/Reed-Sternberg cells in Hodgkin's disease. (1998) (64)
Switch from hapten-specific immunoglobulin M to immunoglobulin D secretion in a hybrid mouse cell line. (1981) (63)
IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cells. (2006) (63)
Transfected plasmacytoma cells do not transport the membrane form of IgM to the cell surface (1988) (61)
BCR-dependent lineage plasticity in mature B cells (2019) (61)
Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. (2004) (60)
Silencing of B Cell Receptor Signals in Human Naive B Cells (2002) (59)
Antibody repertoires generated by VH replacement and direct VH to JH joining. (2006) (59)
Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin's lymphoma. (2003) (59)
The B Cell Receptor Promotes B Cell Activation and Proliferation through a Non-ITAM Tyrosine in the Igα Cytoplasmic Domain (2006) (58)
Isolation and characterization of anti-monosialoganglioside monoclonal antibody 19-9 class-switch variants. (1985) (57)
Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes. (1982) (56)
The effect of light chain gene expression on the inheritance of an idiotype associated with primary anti‐(4‐hydroxy‐3‐nitrophenyl)acetyl(NP) antibodies (1979) (56)
Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program (2011) (55)
EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells. (2017) (54)
Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development (2009) (53)
A prematurely expressed Ig(kappa) transgene, but not V(kappa)J(kappa) gene segment targeted into the Ig(kappa) locus, can rescue B cell development in lambda5-deficient mice. (1996) (53)
The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition (2017) (53)
Drastic change in idiotypic but not antigen-binding specificity of an antibody by a single amino-acid substitution (1985) (53)
Isolation of myeloma variants with predefined variant surface immunoglobulin by cell sorting. (1978) (53)
Isolated hapten‐binding receptors of sensitized lymphocytes. IV. Expression of immimoglobulin variable regions in (4‐hydroxy‐3‐nitrophenyl) acetyl (NP)‐specific receptors isolated from murine B and T lymphocytes (1979) (52)
Production of high affinity autoantibodies in autoimmune New Zealand Black/New Zealand white F1 mice targeted with an anti-DNA heavy chain. (1999) (51)
The carrier effect and cellular cooperation in the induction of antibodies (1971) (51)
T Cell‐Dependent Antibody Production by Ly‐1 B Cells a (1992) (50)
Spontaneous Immunoglobulin Class Switching in Myeloma and Hybridoma Cell Lines Differs from Physiological Class Switching (1982) (49)
Enhancement of Precise Gene Editing by the Association of Cas9 With Homologous Recombination Factors (2019) (49)
Mechanism of Neonatally Induced Idiotype Suppression and its Relevance for the Acquisition of Self‐tolerance (1984) (49)
Ig heavy chain class switching in Rag-deficient mice. (1998) (49)
Amplification of TCRβ gene rearrangements from micromanipulated single cells: T cells rosetting around Hodgkin and Reed‐Sternberg cells in Hodgkin's disease are polyclonal (1998) (48)
Specific control of responsiveness by two complementing Ir loci in the H‐2 complex (1975) (48)
Isolated hapten-binding receptors of sensitized lymphocytes. III. Evidence for idiotypic restriction of T-cell receptors (1978) (48)
A new V gene expressed in lambda‐2 light chains of the mouse (1987) (47)
Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma (2014) (47)
T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells. (1992) (47)
DETERMINATION OF ANTIBODY CLASS IN A SYSTEM OF COOPERATING ANTIGENIC DETERMINANTS (1970) (47)
Carrier specificity and the allogeneic effect in mice (1972) (46)
Isolated hapten-binding receptors of sensitized lymphocytes. II. Receptors from nylon wool-enriched rabbit T lymphocytes lack serological determinants of immunoglobulin constant domains but carry the A locus allotypic markers (1977) (46)
B cell recruitment and selection in mouse GALT germinal centers. (2006) (46)
Direct in vivo VH to JH rearrangement violating the 12/23 rule (2005) (45)
Generation of a mouse strain that produces immunoglobulin kappa chains with human constant regions. (1993) (45)
Molecular basis of an isogeneic anti‐idiotypic response. (1984) (44)
Paralysis to serum albumins in T and B lymphocytes in mice. Dose dependence, specificity and kinetics of escape (1974) (44)
A c-Myc/miR17-92/Pten Axis Controls PI3K-Mediated Positive and Negative Selection in B Cell Development and Reconstitutes CD19 Deficiency. (2016) (43)
Early and late B-cell development in the mouse. (1992) (42)
Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation (2001) (42)
Dividing cells in bone marrow and spleen incorporate bromodeoxyuridine with high efficiency (1991) (42)
The expression of a set of antibody variable regions in lipopolysaccharide‐reactive B cells at various stages of ontogeny and its control by anti‐idiotypic antibody (1983) (41)
Postnatal DNA demethylation and its role in tissue maturation (2018) (41)
Regulation of Repertoire Development through Genetic Control of DH Reading Frame Preference1 (2008) (41)
Immunoglobulin V region variants in hybridoma cells. I. Isolation of a variant with altered idiotypic and antigen binding specificity. (1982) (41)
Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions. (2001) (40)
IκB Kinase 2 Deficiency in T Cells Leads to Defects in Priming, B Cell Help, Germinal Center Reactions, and Homeostatic Expansion1 (2004) (40)
Idiotypic selection of an antibody mutant with changed hapten binding specificity, resulting from a point mutation in position 50 of the heavy chain. (1986) (39)
Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis (2010) (39)
Isolation of a cloned cell line expressing variant H–2Kk using fluorescence-activated cell sorting (1981) (39)
Signaling by the Epstein–Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses (2018) (39)
Specificity, duration and mechanism of idiotype suppression induced by neonatal injection of monoclonal anti‐idiotope antibodies into mice (1984) (38)
Major histocompatibility complex class II hyperexpression on B cells in interleukin 4‐transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia (1991) (38)
Specific enrichment of antigen‐binding receptors from sensitized murine lymphocytes (1976) (37)
A Single DH Gene Segment Creates Its Own Unique CDR-H3 Repertoire and Is Sufficient for B cell Development and Immune Function1 (2005) (37)
M17: a novel gene expressed in germinal centers. (1994) (35)
B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage (2017) (35)
CD5‐positive B cells in healthy elderly humans are a polyclonal B cell population (2000) (35)
Inflammation in Mice Ectopically Expressing Human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T Mutant Proteins* (2013) (34)
Isolation of viable Hodgkin and Reed-Sternberg cells from Hodgkin disease tissues. (1998) (33)
Specificity of Helper Function (1971) (33)
CIN85 drives B cell responses by linking BCR signals to the canonical NF-κB pathway (2011) (33)
Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells. (2018) (33)
miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation. (2016) (33)
Cell autonomous expression of IgD is not essential for the maturation of conventional B cells. (1991) (32)
Single-cell PCR analysis of T helper cells in human lymph node germinal centers. (2000) (32)
The bulk of endogenously produced IgG2a is eliminated from the serum of adult C57BL/6 mice with a half‐life of 6–8 days (1986) (32)
B-cell development in progressively transformed germinal centers: similarities and differences compared with classical germinal centers and lymphocyte-predominant Hodgkin disease. (2001) (32)
IκB Kinase 2/β Deficiency Controls Expansion of Autoreactive T Cells and Suppresses Experimental Autoimmune Encephalomyelitis1 (2007) (32)
Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence. (2015) (31)
The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain. (2006) (31)
Molecular single-cell analysis of the clonal relationship of small Epstein-Barr virus-infected cells and Epstein-Barr virus-harboring Hodgkin and Reed/Sternberg cells in Hodgkin disease. (2000) (31)
A novel gene product associated with mu chains in immature B cells. (1993) (31)
Immunoglobulin heavy and light chain gene sequences of a human CD5 positive immunocytoma and sequences of four novel VHIII germline genes. (1992) (31)
Molecular Single-Cell Analysis of Hodgkin- and Reed-Sternberg Cells Harboring Unmutated Immunoglobulin Variable Region Genes (2001) (31)
A self‐Ia reactive T cell clone directly stimulates every hundredth B cell and helps antigen‐specific B cell responses (1985) (30)
TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells (2019) (30)
Preferential Use of DH Reading Frame 2 Alters B Cell Development and Antigen-Specific Antibody Production1 (2008) (30)
Specificity and heterogeneity of helper T cells in the response to serum albumins in mice (1974) (30)
Differential dependence of CD 4 CD 25 regulatory and natural killer-like T cells on signals leading to NF-B activation (2004) (30)
Single cell analysis of Hodgkin/Reed-Sternberg cells. (1996) (30)
Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains. (1997) (30)
Cd5 B Cells in Development and Disease (1992) (30)
Expression of a Targeted λ1 Light Chain Gene Is Developmentally Regulated and Independent of Igκ Rearrangements (2003) (29)
Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. (2007) (29)
Deletion of IKK 2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia / reperfusion injury (2005) (29)
Efficient generation of B lymphocytes by recognition of self‐antigens (2011) (29)
Variable‐Region Gene Analysis of B‐Cell Subsets Derived from a 4‐Year‐Old Child (1995) (28)
Antibodies generated from human immunoglobulin miniloci in transgenic mice. (1994) (28)
The B-cell antigen receptor integrates adaptive and innate immune signals (2015) (28)
In vivo generation and function of B cells in the presence of a monoclonal anti‐IgM antibody: implications for B cell tolerance (1987) (28)
The advent and rise of monoclonal antibodies (2019) (27)
The carrier effect in the secondary response to hapten‐protein conjugates. IV. Uptake of antigen in vitro and failure to obtain cooperative induction in vitro (1971) (27)
Characterization of an immune response gene in rats (1973) (27)
Idiotope regulation by isotype switch variants of two monoclonal antiidiotope antibodies (1984) (27)
Kreuzreagierende antigene determinanten auf lactatdhydrogenasen I und V acetylierung (1966) (27)
Mouse anti-mouse IgD monoclonal antibodies generated in IgD-deficient mice. (1995) (26)
Immunologische spezifität von lactatdehydrogenase isozymen dreiner säugetier-organismen (1964) (26)
Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice. (2013) (26)
Heterogeneous and monoclonal helper T cells induce similar anti‐(4‐hydroxy‐3‐nitrophenyl)acetyl (NP) antibody populations in the primary adoptive response I. Isotype distribution (1984) (25)
Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes (2013) (25)
Ig-alpha cytoplasmic truncation renders immature B cells more sensitive to antigen contact. (1999) (25)
A B Cell Receptor with Two Igα Cytoplasmic Domains Supports Development of Mature But Anergic B Cells (2004) (25)
Tet2 Negatively Regulates Homeostasis and Differentiation of Hematopoietic Stem Cells in Mice (2011) (24)
Isolated hapten‐binding receptors of sensitized lymphocytes: V. Cellular origin of receptor molecules (1979) (24)
CD8(+) T cells in Hodgkin's disease tumor tissue are a polyclonal population with limited clonal expansion but little evidence of selection by antigen. (2000) (24)
The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development (2018) (23)
Immunology: Burnet's unhappy hybrid (1998) (23)
Role of NFUPκB Signaling in Normal and Malignant B Cell Development (2007) (22)
Sequence analysis of non‐expressed immunoglobulin heavy chain loci in clonally related, somatically mutated hybridoma cells. (1985) (22)
Evolutionary and Somatic Immunological Memory (1989) (22)
Immunoglobulin V genes in Reed-Sternberg cells. (1996) (22)
Excision of the Frt-flanked neoR cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination (2007) (21)
Membrane‐bound IgM obstructs B cell development in transgenic mice (1989) (21)
Interleukin-4-deficient mice. (1993) (21)
Mouse model for acute Epstein–Barr virus infection (2016) (21)
DH reading frame bias: evolutionary selection, antigen selection or both? Evolutionary selection. (1991) (21)
Altered directionality in the Cre-LoxP site-specific recombination pathway. (2001) (20)
A dual role for B cells in Plasmodium chabaudi chabaudi (AS) infection? (1994) (20)
Normal and malignant B-cell development with special reference to Hodgkin's disease. (1997) (20)
Detection of clonal lambda light chain gene rearrangements in frozen and paraffin-embedded tissues by polymerase chain reaction. (1995) (20)
VH replacement in primary immunoglobulin repertoire diversification (2015) (20)
Lymphokines regulate immunoglobulin isotype expression in an antigen-specific immune response. (1986) (20)
M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. (2006) (19)
Hodgkin's Disease: Clonal Ig Gene Rearrangements in Hodgkin and Reed‐Sternberg Cells Picked from Histological Sections (1995) (19)
An explanation for the defect in secretion of IgM Mott cells and their predominant occurrence in the Ly‐1 B cell compartment (1992) (19)
Über die Verschiedenheit der Milchsäure-Dehydrogenasen (1960) (19)
Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin κ-chain locus (2007) (19)
Phenotypic and Molecular Characterization of Human Peripheral Blood B-cell Subsets with Special Reference to N-Region Addition and Jκ-Usage in VκJκ-Joints and κ/λ-Ratios ixn Naive Versus Memory B-cell Subsets to Identify Traces of Receptor Editing Processes (1999) (19)
Prairie Dogs Avoid Extreme Inbreeding (18)
CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia (2020) (18)
Role of NFkappaB signaling in normal and malignant B cell development. (2007) (18)
Heterogeneous and monoclonal helper T cells induce similar anti‐(4‐hydroxy‐3‐nitrophenyl)acetyl (NP) antibody populations in the primary adoptive response II. Lambda light chain dominance and idiotope expression (1984) (18)
Analysis of V gene expression in the immune response by cell fusion. (1978) (18)
Signal requirements for growth and differentiation of activated murine B lymphocytes. (1985) (18)
Efficient and Precise CRISPR/Cas9-Mediated MECP2 Modifications in Human-Induced Pluripotent Stem Cells (2019) (18)
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. (2013) (18)
I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis. (2007) (17)
CD5 B cells in the mouse. (1991) (17)
A V region determinant (idiotope) expressed at high frequency in B lymphocytes is encoded by a large set of antibody structural genes. (1984) (17)
Switch from NP-specific IgG3 to IgG1 in the mouse hybridoma cell line S24/63/63. (1982) (17)
'Enhancer-constitutive' vectors for the expression of recombinant antibodies (1988) (17)
Early and late B-cell development in the mouse (1992) (17)
A phenotype or not: targeting genes in the immune system. (1992) (17)
The immune response against anti‐idiotope antibodies II. The induction of antibodies bearing the target idiotope (Ab3β) depends on the frequency of the corresponding B cells (1983) (17)
Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells (2016) (17)
Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase‐, CD23‐, interleukin‐4‐, IgD‐ and CD30‐deficient mouse mutants (1996) (16)
Antibody domain mutants demonstrate autonomy of the antigen binding site. (1990) (16)
A functional antibody mutant with an insertion in the framework region 3 loop of the VH domain: implications for antibody engineering. (1992) (16)
Rabbit antibody to pig lactic dehydrogenase reacting with the rabbit's own enzyme (1966) (16)
Burkitt lymphomagenesis linked to MYC plus PI3K in germinal center B cells (2012) (15)
Generation of long‐lived B cells in germ‐free mice (1991) (15)
Mutation of the p 53 Gene Is Not a Typical Feature of Hodgkin and Reed-Sternberg Cells in Hodgkin ’ s Disease (1999) (14)
Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes. (2001) (14)
The power of clonal selection (1993) (14)
Antigen induces chronic idiotype suppression. (1985) (14)
B-cell lifespans in the mouse--why to debate what? (1993) (14)
Molecular single-cell analysis of Hodgkin and Reed-Sternberg cells. (1995) (14)
Cytokine knockouts. (1996) (13)
Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function (2016) (13)
Symmetry and asymmetry in idiotypic interactions. (1983) (13)
B cell protocols (2004) (13)
Study of Murine B‐Cell Development through Analysis of Immunoglobulin Variable Region Genes a (1992) (13)
The Genetic Control of Immunological Responsiveness to Lactic Dehydrogenase (LDH) Isoenzymes (1970) (12)
Growth and selection of B cells in vivo. (1989) (12)
Inhibition of the Immune response in vitro to Sheep Red Blood Cells by Passive Antibody (1969) (12)
Spontaneous Class Switch Recombination in B Cell Lymphopoiesis Generates Aberrant Switch Junctions and Is Increased after VDJ Rearrangement1 (2007) (12)
LMP 1 signaling can replace CD 40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG 1 (2008) (12)
Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells (2019) (12)
Low affinity of kappa chain bearing (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific antibodies in the primary antibody repertoire of C57BL/6 mice may explain lambda chain dominance in primary anti-NP responses. (1985) (12)
B-cell expansion and lymphomagenesis induced by chronic CD40 signaling is strictly dependent on CD19. (2014) (11)
Somatic H‐2Kk variants reveal nonidentity of serological and cytotoxic T cell‐defined Kk determinants (1983) (11)
Immunological Characteristics of some Lactic Dehydrogenases (1964) (11)
L&H cells in lymphocyte-predominant Hodgkin's disease. (1998) (11)
A Glimpse into the Inner Life of the Immune System (1981) (11)
Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis (2020) (10)
Inhibition of NF-kappa B activation in macrophages increases atherosclerosis in LDL receptor-deficient mice (2003) (10)
EBI 2 Is Highly Expressed i n Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD 4 T Cells (10)
Modulation of antibody binding affinity by somatic mutation (1988) (10)
Ig gene rearrangement and expression in the progeny of B‐cell progenitors in the course of clonal expansion in bone marrow cultures. (1987) (10)
Rainfall Variability, Carbon Cycling, and Plant Species Diversity in a Mesic Grassland (2002) (10)
Tuning somatic hypermutation by transcription. (1999) (10)
Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat (2019) (9)
Antibody Repertoire in a Mouse with a Simplified DH Locus: The D‐Limited Mouse (2003) (9)
Cytoplasmic Igα Serine/Threonines Fine-Tune Igα Tyrosine Phosphorylation and Limit Bone Marrow Plasma Cell Formation (2011) (9)
Lymphocyte development: overview. (2008) (9)
Phenotypic and molecular characterization of human peripheral blood B-cell subsets with special reference to N-region addition and J kappa-usage in V kappa J kappa-joints and kappa/lambda-ratios in naive versus memory B-cell subsets to identify traces of receptor editing processes. (1999) (9)
Common cytokine receptor γ chain (γc)‐deficient B cells persist in T cell‐deficient γc– mice and respond to a T‐independent antigen (2000) (9)
Somatic variation of H‐2Kk expression and structure in a T‐cell lymphoma: instability, stabilization, high production and structural mutation. (1983) (8)
CHAPTER 16 – The Cellular Basis of B Cell Memory (2004) (8)
Years in Cologne. (2013) (8)
The Herzenberg lecture: how to make a B‐1 cell? (2015) (8)
Inexpensive upgrading of a FACS I and isolation of rare somatic variants by double-fluorescence sorting. (1985) (8)
Violation of allelic exclusion of the T cell receptor beta genes in a helper T cell clone. (1989) (8)
Lack of deleterious somatic mutations in the CD95 gene of plasmablasts from systemic lupus erythematosus patients and autoantibody‐producing cell lines (2002) (8)
FUNCTIONAL COMPLEMENTATION AND POLYMORPHISM OF H-2 LINKED IMMUNE RESPONSE GENES (1978) (8)
Influence of dendritic structure on firing pattern in model neocortical neurons (1996) (8)
Erratum: Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells (2018) (8)
Spontaneous loss and subsequent stimulation ofH-2 expression in clones of a heterozygous lymphoma cell line (1979) (8)
Perspectives Series: Molecular Medicine in Genetically Engineered Animals (1996) (7)
A novel conditional Aire allele enables cell‐specific ablation of the immune tolerance regulator Aire (2018) (7)
Interferon-g impacts at multiple points during the progression of autoimmune diabetes (nonobese diabetic miceyknock-out miceyautoimmune diseaseycytokine) (1997) (7)
Targeted disruption of the VH 81X gene: Influence on the B cell repertoire (1997) (7)
The magnitude of germinal center reactions is restricted by a fixed number of preexisting niches (2021) (6)
Lymphocyte development: Editorial overview (1991) (6)
Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes (2020) (6)
The c-Myc / miR 1792 / PTEN Axis Tunes PI 3 K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development (2018) (6)
Similar surface areas on acetylated lactic dehydrogenases. (1967) (6)
Igλ+ B cell development but not Igκ editing depends on NF-κB signals (2009) (6)
Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation (2019) (5)
A novel allele for inducible Cre expression in germinal center B cells (2018) (5)
Induction of chronic idiotype suppression by ligands binding to the variable (not the constant) region of the idiotypic target (1986) (5)
Immunology. The power of clonal selection. (1993) (5)
From a Dream to Reality (2007) (5)
Hoppe-Seyler ' s Zeitschrift für Physiologische Chemie Band 365 — 2 . Jahreshälfte (2011) (5)
Precise CRISPR-Cas–mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells (2022) (5)
Protocol for Efficient CRISPR/Cas9/AAV-Mediated Homologous Recombination in Mouse Hematopoietic Stem and Progenitor Cells (2020) (5)
ANTIGEN RECEPTORS ON MOUSE T LYMPHOCYTES (1978) (4)
Resistance to murine acquired immunodeficiency syndrome (MAIDS) (1994) (4)
CRISPR/Cas9-Mediated In Vitro Mutagenesis in GC-Like B Cells. (2017) (4)
Mutation and Selection of Antibodies (1986) (4)
A c-Myc / miR 1792 / Pten A xis Controls PI 3 K-Mediated Positive and Negative Selection in B Cell Development and Reconstitutes CD 19 Deficiency Graphical (2016) (4)
The isolation of thirteen cloned hybrid cell lines secreting mouse strain A derived antibodies with specificity for group A streptococcal carbohydrate. (1978) (4)
Repertoire Selection in B Cell Subpopulations (1989) (4)
Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells (2022) (4)
Fc-dependent effector functions of idiotype-anti-idiotype immune complexes. (1984) (4)
Expression of IgH promoter/enhancer Ly-1 transgene in hematopoietic chimeric mice generated by embryonic stem cell line. (1990) (4)
The germinal center reaction and human B cell lymphomas (2001) (3)
Common cytokine receptor gamma chain (gammac)-deficient B cells persist in T cell-deficient gammac-mice and respond to a T-independent antigen. (2000) (3)
RESISTANCE TO MURINE ACQUIRED-IMMUNODEFICIENCY-SYNDROME (MAIDS) - COMMENT (1994) (3)
Pillars Article: Independent Control of Immunoglobulin Switch Recombination at Individual Switch Regions Evidenced through Cre-loxP-Mediated Gene Targeting. Cell. 1993. 73: 1155-1164 (2013) (3)
Correction: T cell–derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia (2013) (3)
A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1 (2015) (3)
ALLELIC EXCLUSION MODEL QUESTIONED - REPLY (1992) (3)
Development of immunoglobulin k-chain – positive B cells , but not editing of immunoglobulin j-chain , depends on NF-j B signals (2009) (3)
Adhesion to substrate as a developmental process in murine teratoma embryoid bodies. (1975) (3)
T LYMPHOCYTE RECEPTOR ANALYSIS BY ANTI – IDIOTYPIC STIMULATION (1976) (3)
H-2 LINKED IMMUNE RESPONSE GENES: MULTIPLICITY AND FUNCTIONAL COMPLEMENTATION (1976) (3)
B-Cell-Specific Myd88 L252P Expression Causes a Premalignant Gammopathy Resembling IgM MGUS (2020) (3)
B-cell antigen receptor expression and phosphatidylinositol 3-kinase signaling regulate genesis and maintenance of mouse chronic lymphocytic leukemia (2022) (3)
Über eine biologische Wirkung der Desoxyribonuclease I auf die Entwicklung befruchteter Eier von Sphaerechinus granularis (2004) (2)
The Significance of the Carrier Effect for the Induction of Antibodies (1969) (2)
Mechanisms of Idiotypic Control of the Antibody Repertoire (1984) (2)
Genetic Control of T and B Cell Receptor Specificity in the Mouse (1976) (2)
Obituary: César Milstein (1927–2002) (2002) (2)
motility miR-155 regulates HGAL expression and increases lymphoma cell (2012) (2)
ldots histocompatibility complex class II hyperexpression on B cells in interleukin 4-transgenic mic (1991) (2)
IRF-4/MUM-1 Expression Is a Critical Switch in the Generation of Plasma Cells Versus Memory B-Cells. (2005) (2)
Functional analysis of a self-I-A reactive T-cell clone which preferentially stimulates activated B cells. (1986) (2)
Isolation of variants of mouse myeloma X 63 that express changed (2)
Isolation of immunoglobulin class-switch and variable-region variants from mouse myeloma and hybridoma cell lines. (1982) (2)
Mechanisms of Lymphocyte Activation and Immune Regulation XI (2007) (2)
Pillars article: a critical role of lambda 5 protein in B cell development. Cell. 1992. 69: 823-831. (2010) (1)
INFLAMMATORY BOWEL-DISEASE IN IL-10 DEFICIENT MICE (1994) (1)
A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation (2023) (1)
[IMMUNOLOGICAL SPECIFICITY OF LACTATE DEHYDROGENASE ISOZYMES FROM 3 MAMMALIAN ORGANISMS]. (1964) (1)
Concomitant Cytotoxic Effector Differentiation of CD4+ and CD8+ T Cells in Response to EBV-Infected B Cells (2022) (1)
Skewed B cell differentiation affects lymphoid organogenesis but not T cell‐mediated autoimmunity (2014) (1)
Lymphocyte development essential features. (1997) (1)
A structural somatic variant of the Kk antigen is generated by point mutation (2004) (1)
Anti-DNA Heavy Chain Germline-Encoded or Somatically Mutated in ''Knock In'' Mice Targeted with a B Cell Deletion, Anergy, and Receptor Editing (1998) (1)
Enzymprotein als Antigen Immunologische Studien an Lactatdehydrogenasen (1965) (1)
[Detection of clonal immunoglobulin rearrangements in paraffin embedded tissues by PCR]. (1992) (1)
Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability (2020) (1)
Reed-Sternberg cells of Hodgkin lymphoma specific gene expression program in Hodgkin and - Loss of the B-lineage (2013) (1)
Conditional disruption of IkB kinase 2 fails to prevent obesity-induced insulin resistance (2018) (1)
Somatic antibody mutants. (1989) (1)
Physiology-Independent Roles for BAFF in B Cell Factor ( BAFF ) Receptor-Dependent and TNF Family Member B Cell-Activating (2004) (1)
Immunological memories. (1989) (1)
myelination replaces Nrg 1 / ErbB 3 signals during Schwann cell development and Activation of MAPK overrides the termination of myelin growth and Material (2014) (1)
Role of STAT3 and Th17 Cells in Cutaneous T Cell Lymphoma (2012) (1)
Joining the Institute of Genetics Early On as an Immunologist (2007) (1)
Advances in Brief Somatic Mutations of the CD 95 Gene in Hodgkin and Reed-Sternberg Cells 1 (2000) (1)
Helper T cells reacting to idiotype on IgG but not IgM (1985) (1)
Frontmatter (1982) (0)
Cell type-specific ablation of MHC class II expression on subsets of antigen presenting cells by CRE/LOXP-mediated deletion of RFX5 (1997) (0)
Short title: B cell specific LMP1 signaling substitutes CD40 (2007) (0)
Immunoglobulin genes: edited by T. Honjo, F.W. Alt and T.H. Rabbitts, Academic Press, 1990 540.00 (xiii + 410 pages) ISBN 0 12 354865 9 (1990) (0)
New EMBO members elected in the 1989 ballot (1989) (0)
GSE68043: PI3 Kinase and FOXO1 activity differentially control B cells in the germinal center light and dark zone (2015) (0)
A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma (2022) (0)
[Problems of cell cooperation in the humoral immune reaction]. (1973) (0)
Preclinical models of human multiple myeloma subgroups (2021) (0)
with Immunoglobulin (Ig) (cid:2) Immunoreceptor Tyrosine–based Activation Motif (ITAM) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Ig (cid:3) Cytoplasmic Tail (2001) (0)
PLC- (cid:2) 2 is essential for formation and maintenance of memory B cells (2009) (0)
[Immune dysregulation and malignant lymphoma]. (1995) (0)
Ligand inducible, B cell-specific gene targeting in mice (1997) (0)
Addiction of B Cell Lymphomas to microRNA-17-92 Is Mediated By a Single Target Gene (2019) (0)
The origin of the Hodgkin and Reed-Sternberg (HRS) cells in Hodgkin's disease and their relationship to HRS-like cells occuring in B-cell chronic lymphatic leukemia (1997) (0)
6 Endogenous RNA Interference Influences Cytokine Gene Expression (2007) (0)
Principles of B cell selection in vitro (1990) (0)
Erratum (Retracted article): (November 18, 2002) 196, 10, (1291-1305) (2006) (0)
Erratum (2004) (0)
Title Gab 1 and Mapk Signaling Are Essential in the Hair Cycle andHair Follicle Stem Cell Quiescence (2019) (0)
Isotype switching in myeloma and hybridoma cells compared with LPS blasts (1984) (0)
A method of replacing homologous gene segments from the germ line of mammals in non-human mammals (1992) (0)
Abstracts of papers presented at the 1998 Workshop on Conditional Genetic Technologies in the Mouse, August 31-September 2, 1998 (1998) (0)
An Integrated Cellular and Molecular Model of Gastric Neuroendocrine Cancer Evolution Highlights Therapeutic Targets (2022) (0)
NF-kappa B and cMyc cooperate to induce B-cell transformation and plasma cell neoplasia (2013) (0)
Novel insights into Th17 mediated airway inflammation (HYP7P.259) (2015) (0)
Itnpaired Immunosuppressive Response to Ultraviolet Radiation in Interleukin-l 0-Deficient Mice (2010) (0)
Dear Granger: I appreciate the opportunity to submit a revised manuscript to Cell Metabolism entitled: “Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity”. We have modified the manuscript to include most of the experiments the reviewers suggested. Below (0)
Editorial Board (1995) (0)
AnOncogenic Role for Alte rnative NFk B Signaling in DLBCLRevealed uponDeregulatedBCL 6 Expression Graphical Abstract Highlights (0)
bronchoconstriction in mice with airway inflammation Nonlinearity of respiratory mechanics during (2015) (0)
The DNA Deamination Model of Somatic Antibody Diversification (2015) (0)
Erratum: Memory B-cell persistence is independent of persisting immunizing antigen (2001) (0)
B-cell maintenance, response and surveillance (ML11)Chairperson: Toshitada Takemori (2010) (0)
Conditional inactivation of the Csk gene during T cell development (1997) (0)
Antigenic determinants and tolerance specificity. (1969) (0)
Isolation and characterization of h-2 variants with the fluorescence activated cell sorter. Abstr. (1979) (0)
Requirement of mammalian DNA polymerase-β in base-excision repair (1996) (0)
The Use of Different Carriers for Primary and Secondary Stimulation (2003) (0)
Myc and the Warburg Effect (2018) (0)
Editorial Board (1995) (0)
Lymphocyte development. (1993) (0)
Roles of MicroRNAs in B Lymphocyte Physiology and Oncogenesis (2015) (0)
This information is current as Formation and Limit Bone Marrow Plasma Cell Tyrosine Phosphorylation α Fine-Tune Ig Serine / Threonines α Cytoplasmic (2011) (0)
WITHDRAWN: Lymphocyte development. Overview (2008) (0)
Postnatal DNA demethylation and its role in tissue maturation (2018) (0)
Inhibition of NFk B activation in macrophages increases atherosclerosis in LDL receptor – deficient mice (2018) (0)
Suppresses Experimental Autoimmune Expansion of Autoreactive T Cells and Deficiency Controls β (2013) (0)
Parabiosis as a Model System for Network Interactions (1981) (0)
[Cross-reacting antigenic determinants on lactate dehydrogenases I and V by acetylation]. (1966) (0)
Physiologie der B-Lymphozyten (2003) (0)
B cell memory (WS-081) Chairpersons: Masaki Hikida, David Tarlinton (2010) (0)
Gene-targeting studies of DH reading frame in V(D)J recombination (1999) (0)
Identification of the Sex Pheromone of the German Cockroach, Blattella germanica (2005) (0)
B cells are addicted to immunoglobulin production in the ER (2022) (0)
This work employed antibodies to Group A streptococcal carbohydrate (A-CHO), generated in strain A/J mice by immunization with Group A streptococcal vaccine (2003) (0)
The immune system : 27. colloquium der Gesellschaft für Biologische Chemie, 29. April-1. Mai 1976 in Mosbach/Baden (1976) (0)
" " " " " " " " " " " " " " " " " " " " " " (2003) (0)
Frontmatter (1982) (0)
" " " " " " " " " " " " " " " " " " " " " " (2003) (0)
George Klein: 1925–2016 (2017) (0)
miR-23~27~24 clusters restrict Th2 immunity and associated immunopathology during airway allergic reaction (HYP2P.335) (2015) (0)
Transposition: Ein neuer Mechanismus zur Evolution. Antikörperdiversität und Netzwerkregulation im Immunsystem (1984) (0)
Antikörperdiversität und Netzwerkregulation im Immunsystem (1984) (0)
Faculty Opinions recommendation of Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development. (2007) (0)
Molekulare Analyse der Hodgkin- und Reed/Sternberg-Zellen des Morbus Hodgkin mittels Mikromanipulation und Einzelzell-PCR (1997) (0)
Molekulare Immunologie und Klinik (1987) (0)
Immunologie. Von G. Bundschuh und B. Schneeweiß. Gustav Fischer Verlag, Stuttgart—New York 1976. 1. Aufl., XXXIV, 451 S., Ln. DM 42.00 (1978) (0)
Gene-targeting studies of DH reading frame choice in V-D-J recombination (1998) (0)
model of chronic mucosal inflammation (1995) (0)
Allelic exclusion model questioned (1992) (0)
Expression of Hyperactivable NFAT1 from the ROSA26 Locus Leads to Detrimental Effects during Embryonic Development. (2007) (0)
miR-142 favors naïve B cell residence in peripheral lymph nodes (2022) (0)
Table of Contents (1993) (0)
Myelo- and lympho-proliferative disorders (WS-035) Chairpersons: Nagahiro Minato, Gilbert Faure (2010) (0)
Generating mouse models of disease through gene targeting (1994) (0)
IDIOTYPIC IDENTITY OF STREP. A SPECIFIC ANTIGEN RECOGNITION SITES ON MOUSE T AND B-LYMPHOCYTES (1976) (0)
Conditional Knockout of Sox4 Markedly Affects B Lymphopoiesis in Adult Mice. (2009) (0)
Lymphotoxin β-deficient mice: Requirement of the LTα/β heterotrimers for the development of peripheral lymphoid organs, except the mesenteric lymph node (1997) (0)
Table of Contents (1986) (0)
β7 INTEGRINS ARE IMPORTANT, BUT NOT INDISPENSABLE TO INTESTINAL ALLOGRAFT REJECTION (1999) (0)
Efficient CRISPR/Cas9-Mediated Gene Knock-In in Mouse Hematopoietic Stem/Progenitor Cells (2019) (0)
Role of miR-27 in controlling T cell immunity (IRM15P.605) (2015) (0)
Mouse models of human multiple myeloma subgroups. (2023) (0)
Antibodies generated fromhumanimmunoglobulin miniloci intransgenic mice (1994) (0)
Detection of Clonal A Light Chain Gene Rearrangements in Frozen and Paraffin-Embedded Tissues by Polymerase Chain Reaction (2007) (0)
Erratum to: Profiling of Hodgkin’s Lymphoma Cell Line L1236 and Germinal Center B Cells: Identification of Hodgkin’s Lymphoma-specific Genes (2003) (0)
c-Myb is a novel regulator of Bcl-xL in the CD4+ and CD8+ double positive stage of T cell development (85.2) (2009) (0)
HST.176 Cellular and Molecular Immunology, Fall 2002 (2002) (0)
The regulation of the immune system by receptor-mediated cell interactions. (1979) (0)
Generation and characterization of mice with a targeted deletion of the entire TNF/lymphotoxin locus (TNFÎ±, LTÎ±, LTÎ²) employing CRE-loxP mediated recombination (1997) (0)
Evidence for NFAT1 as a Tumor Suppressor in T-ALL (2008) (0)
Michael S. Neuberger 1953–2013 (2014) (0)
Editorial Board (1995) (0)
Conditional inactivation of gp130 in mice (1997) (0)
Receptors and Cell Collaboration in the Immune System (1980) (0)
The Role of the Transcription Factor NFAT in the Pathogenesis of Non-Hodgkin’s Lymphomas. (2006) (0)
Table of Contents (1984) (0)
Neuberger 1953-2013 (2014) (0)
Efficient CRISPR-Cas9-mediated mutagenesis in primary human B cells for identifying plasma cell regulators (2022) (0)
Application of a Spacer-nick Gene-targeting Approach to Repair Disease-causing Mutations with Increased Safety (2023) (0)
Identification of microRNA Targets by Azra Krek (2009) (0)
Resource Efficient CRISPR / Cas 9-Me diated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells Graphical (0)
T cells rosetting around the tumor cells in Hodgkin's disease: Analysis of TCR gene rearrangements by single cell PCR (1997) (0)
c-Myb is crucial for B-lymphocyte development (138.30) (2009) (0)
Table of Contents (1993) (0)
Fusion of Myeloma Cells with Mouse Lymphocytes (1977) (0)
Frontmatter (1982) (0)
Lymphocyte development Commitment, selection and switching (2000) (0)
sgRNA Sequence Motifs B locking Efficient CRISPR / Cas 9-Mediated Gene Editing Graphical (2019) (0)
Corrigendum: Enhancement of Precise Gene Editing by the Association of Cas9 With Homologous Recombination Factors (2020) (0)
Antibodies against epitopes with homology to auto-antigens, methods of making and uses thereof (1995) (0)
Book Review: Immunologie (Immunology). By G. Bundschuh and B. Schneeweiss (1978) (0)
Anti-DNA Heavy Chain Mice Targeted with an 1 Zealand White F Autoimmune New Zealand Black/New Production of High Affinity Autoantibodies in (1999) (0)
miRNAs are critical for the regulation of RAG expression and secondary Ig rearrangement in peripheral B lymphocytes (2016) (0)

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