Pierre Chambon

Q: What Schools Are Affiliated With Pierre Chambon

Pierre Chambon is affiliated with the following schools: University of Bonn, University of Rennes 1, Harvard University, University of Lausanne, University of Liège, University of Tokyo, University of Strasbourg, Stanford University, Baylor College of Medicine, Cornell University

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Pierre Chambon

Biology

#166

World Rank

#302

Historical Rank

Molecular Biology

#44

World Rank

#44

Historical Rank

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Biology

Pierre Chambon's Degrees

PhD Biochemistry University of Strasbourg

Why Is Pierre Chambon Influential?

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According to Wikipedia, Pierre Chambon was the founder of the in Strasbourg, France. He was one of the leading molecular biologists who utilized gene cloning and sequencing technology to first decipher the structure of eukaryotic genes and their modes of regulation. His major contributions to science include the identification of RNA polymerase II , the identification of transcriptional control elements, the cloning and dissection of nuclear hormone receptors, revealing their structure and showing how they contribute to human physiology. His group was also one of the first to demonstrate, biochemically and electron-microscopically, that the nucleosome is the smallest unit of chromatin . He accomplished much of his work in the 1970s – 1990s.

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Pierre Chambon's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The nuclear receptor superfamily: The second decade (1995) (6907)
Organization and expression of eucaryotic split genes coding for proteins. (1981) (3627)
A decade of molecular biology of retinoic acid receptors (1996) (2953)
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A (1986) (2302)
A human retinoic acid receptor which belongs to the family of nuclear receptors (1987) (2089)
Isolation of high-molecular-weight DNA from mammalian cells. (1973) (1560)
Two distinct estrogen‐regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. (1990) (1536)
Functional domains of the human estrogen receptor (1987) (1251)
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas (1990) (1161)
A Unified Nomenclature System for the Nuclear Receptor Superfamily (1999) (1152)
The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer (1988) (1117)
TIF2, a 160 kDa transcriptional mediator for the ligand‐dependent activation function AF‐2 of nuclear receptors. (1996) (1105)
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development (1999) (1063)
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. (1997) (1062)
Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life? (1995) (1053)
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α (1995) (1036)
Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. (2000) (1013)
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently (1992) (982)
Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants. (1994) (969)
Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. (1997) (956)
A canonical structure for the ligand-binding domain of nuclear receptors (1996) (955)
Identification of a second human retinoic acid receptor (1988) (946)
Nuclear receptors enhance our understanding of transcription regulation. (1988) (937)
Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid (1995) (920)
Tissue‐specific and inducible Cre‐mediated recombination in the gut epithelium (2004) (902)
Ligand-activated site-specific recombination in mice. (1996) (872)
Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. (1978) (861)
In vivo sequence requirements of the SV40 early promoter region (1981) (855)
Multiplicity generates diversity in the retinoic acid signalling pathways. (1992) (831)
A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. (2000) (829)
Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts (2007) (803)
Role of the two activating domains of the oestrogen receptor in the cell‐type and promoter‐context dependent agonistic activity of the anti‐oestrogen 4‐hydroxytamoxifen. (1990) (782)
Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants. (1994) (779)
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor (2003) (773)
DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor. (1993) (772)
Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. (1999) (758)
Electron microscopic and biochemical evidence that chromatin structure is a repeating unit (1975) (755)
A reliable method for the recovery of DNA fragments from agarose and acrylamide gels. (1981) (734)
Genetic analysis of RXRα developmental function: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis (1994) (723)
Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. (1982) (709)
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. (1993) (706)
Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin (1989) (690)
Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression (1991) (681)
Promoter sequences of eukaryotic protein-coding genes. (1980) (673)
The chicken oestrogen receptor sequence: homology with v‐erbA and the human oestrogen and glucocorticoid receptors. (1986) (673)
A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene (1993) (644)
The N‐terminal part of TIF1, a putative mediator of the ligand‐dependent activation function (AF‐2) of nuclear receptors, is fused to B‐raf in the oncogenic protein T18. (1995) (632)
The ovalbumin gene-sequence of putative control regions (1980) (632)
Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. (2006) (619)
Functional interaction between PARP‐1 and PARP‐2 in chromosome stability and embryonic development in mouse (2003) (600)
A third human retinoic acid receptor, hRAR-gamma. (1989) (597)
Nicotinamide mononucleotide activation of new DNA-dependent polyadenylic acid synthesizing nuclear enzyme. (1963) (589)
Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis. (1990) (576)
The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. (2001) (566)
High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. (1993) (562)
Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase. (1995) (561)
Function of retinoic acid receptor γ in the mouse (1993) (550)
A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. (1996) (548)
Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development (1997) (547)
The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants. (1981) (544)
The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function (1988) (542)
Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos. (1991) (535)
Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene* (2000) (534)
Steroid hormone receptors compete for factors that mediate their enhancer function (1989) (534)
The retinoid signaling pathway: molecular and genetic analyses. (1994) (533)
Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling (2008) (532)
Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. (1995) (532)
A Microenvironment-Induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor γ Deficiency (2007) (506)
Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein (1996) (505)
Jarid2 and PRC2, partners in regulating gene expression. (2010) (488)
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. (2007) (477)
Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex (1990) (476)
Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor (2011) (476)
International Union of Pharmacology. LXIII. Retinoid X Receptors (2006) (472)
Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element (1989) (460)
Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod. (1996) (455)
Site- and time-specific gene targeting in the mouse. (2001) (451)
Modulation of transcriptional activation by ligand‐dependent phosphorylation of the human oestrogen receptor A/B region. (1993) (447)
Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. (1992) (444)
Retinoid X receptor gamma signaling accelerates CNS remyelination (2011) (440)
Localisation of the oestradiol‐binding and putative DNA‐binding domains of the human oestrogen receptor. (1986) (437)
SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues (2002) (435)
Paracrine signaling through the epithelial estrogen receptor α is required for proliferation and morphogenesis in the mammary gland (2006) (435)
Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development. (1997) (434)
Eukaryotic nuclear RNA polymerases. (1975) (431)
Differential expression of genes encoding α, β and γ retinoic acid receptors and CRABP in the developing limbs of the mouse (1989) (422)
Folding of the DNA double helix in chromatin-like structures from simian virus 40. (1975) (419)
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. (2006) (418)
α-Amanitin: A specific inhibitor of one of two DNA-dependent RNA polymerase activities from calf thymus (1970) (414)
Impaired skin wound healing in peroxisome proliferator–activated receptor (PPAR)α and PPARβ mutant mice (2001) (410)
Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbiota Cues Transduced by TLRs (2013) (410)
Two rhombomeres are altered in Hoxa-1 mutant mice. (1993) (407)
Differential ligand‐dependent interactions between the AF‐2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. (1996) (407)
Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins. (2001) (403)
The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties. (1989) (400)
Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. (2001) (398)
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development (2004) (390)
Retinoic acid synthesis and hindbrain patterning in the mouse embryo. (2000) (390)
Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains. (2000) (388)
The N-terminal region of the chicken progesterone receptor specifies target gene activation (1988) (388)
Estrogen Receptor-&agr; Mediates the Protective Effects of Estrogen Against Vascular Injury (2002) (387)
All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs (1992) (382)
Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts. (1997) (379)
Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid. (1991) (378)
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network (2009) (377)
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. (2008) (376)
International Union of Pharmacology. LX. Retinoic Acid Receptors (2006) (375)
Attenuation of Colon Inflammation through Activators of the Retinoid X Receptor (Rxr)/Peroxisome Proliferator–Activated Receptor γ (Pparγ) Heterodimer (2001) (374)
Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. (2004) (372)
Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor (1987) (371)
Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol (2003) (367)
Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1 (1991) (367)
Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing. (1991) (358)
In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE). (1997) (358)
Activation function 2 (AF‐2) of retinoic acid receptor and 9‐cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF‐2 activity. (1994) (356)
Regeneration of fat cells from myofibroblasts during wound healing (2017) (356)
Impaired locomotion and dopamine signaling in retinoid receptor mutant mice. (1998) (355)
hTAF(II)68, a novel RNA/ssDNA‐binding protein with homology to the pro‐oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II. (1996) (354)
Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7. (1984) (352)
Multiple sequence motifs are involved in SV40 enhancer function. (1986) (348)
Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. (1988) (348)
The human oestrogen receptor functions in yeast (1988) (347)
Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site. (1990) (342)
Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription (1984) (339)
Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis. (1990) (337)
A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse (2003) (336)
Function of retinoic acid receptors during embryonic development (2009) (335)
Stimulation of RARα Activation Function AF-1 through Binding to the General Transcription Factor TFIIH and Phosphorylation by CDK7 (1997) (331)
Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning. (1998) (330)
Distinct classes of transcriptional activating domains function by different mechanisms (1990) (328)
Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis (2000) (327)
Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch. (1998) (327)
NSD1 is essential for early post‐implantation development and has a catalytically active SET domain (2003) (326)
Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors (1992) (325)
PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR. (1993) (325)
Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons (2009) (325)
Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes (2000) (324)
Ovalbumin gene is split in chicken DNA (1977) (323)
Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene (1996) (322)
Cooperation of proto‐signals for nuclear accumulation of estrogen and progesterone receptors. (1992) (320)
Cellular retinol‐binding protein I is essential for vitamin A homeostasis (1999) (317)
Cloning of the human oestrogen receptor cDNA. (1986) (316)
PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes (2006) (313)
Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence. (1989) (312)
The bromodomain revisited. (1997) (310)
Abnormal spermatogenesis in RXR beta mutant mice. (1996) (308)
Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor. (1990) (308)
Developmental expression of murine retinoid X receptor (RXR) genes (1994) (306)
RARs and RXRs: evidence for two autonomous transactivation functions (AF‐1 and AF‐2) and heterodimerization in vivo. (1993) (303)
Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions. (1985) (303)
A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment (2003) (302)
Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription (2001) (298)
On the formation of a novel adenylic compound by enzymatic extracts of liver nuclei (1966) (297)
Efficient, inducible Cre‐recombinase activation in vascular endothelium (2008) (294)
Premature ovarian failure in androgen receptor-deficient mice. (2006) (293)
Crystal structure of the human RXRα ligand‐binding domain bound to its natural ligand: 9‐cis retinoic acid (2000) (293)
Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation (2007) (292)
The yeast UASG is a transcriptional enhancer in human hela cells in the presence of the GAL4 trans-activator (1988) (291)
Direct Regulation of Blood Pressure by Smooth Muscle Cell Mineralocorticoid Receptors (2012) (291)
Suppressive function of androgen receptor in bone resorption (2003) (287)
A far upstream estrogen response element of the ovalbumin gene contains several half-palindromic 5′-TGACC-3′ motifs acting synergistically (1992) (284)
Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning. (1996) (283)
Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7. (1984) (282)
Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice. (2007) (281)
Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2. (1987) (281)
Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene (1992) (278)
Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequences (1983) (278)
The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific. (1989) (278)
Estradiol enhances primary antigen‐specific CD4 T cell responses and Th1 development in vivo. Essential role of estrogen receptor α expression in hematopoietic cells (2003) (277)
Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. (2002) (277)
Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells (2003) (277)
Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. (2005) (275)
Developmental analysis of the retinoic acid-inducible RAR-beta 2 promoter in transgenic animals. (1991) (274)
Murine isoforms of retinoic acid receptor gamma with specific patterns of expression. (1990) (271)
DNA methylation: organ specific variations in the methylation pattern within and around ovalbumin and other chicken genes. (1979) (269)
RAR‐specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage‐independent cell proliferation. (1995) (269)
Increased anxiety and synaptic plasticity in estrogen receptor β-deficient mice (2001) (267)
Brain masculinization requires androgen receptor function. (2004) (266)
The Function of TIF2/GRIP1 in Mouse Reproduction Is Distinct from Those of SRC-1 and p/CIP (2002) (263)
A retinoic acid-responsive element is present in the 5' flanking region of the laminin B1 gene. (1989) (263)
Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators (1998) (262)
Homeobox Genes in Embryogenesis and Pathogenesis (1997) (258)
Estradiol Accelerates Reendothelialization in Mouse Carotid Artery Through Estrogen Receptor-α but Not Estrogen Receptor-β (2001) (257)
Carcinogenesis: A superfamily of potentially oncogenic hormone receptors (1986) (256)
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis (2013) (256)
Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse (2002) (256)
The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c‐Ha‐ras oncoprotein and the c‐jun protein. (1989) (253)
The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full‐length receptors to direct repeats. (1994) (247)
Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells (2005) (246)
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. (2005) (246)
A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I. (2000) (243)
Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis. (2006) (243)
Signal transduction by steroid hormones: nuclear localization is differentially regulated in estrogen and glucocorticoid receptors. (1990) (241)
Spatio-temporally controlled site-specific somatic mutagenesis in the mouse. (1997) (240)
Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells (*) (1995) (239)
Retinoic acid receptors and cellular retinoid binding proteins. III. Their differential transcript distribution during mouse nervous system development. (1993) (238)
Mice deficient in cellular retinoic acid binding protein II (CRABPII) or in both CRABPI and CRABPII are essentially normal. (1995) (237)
Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells. (1997) (236)
Function of retinoic acid receptor gamma in the mouse. (1993) (236)
Abnormal expression of retinoic acid receptors and keratin 19 by human oral and epidermal squamous cell carcinoma cell lines. (1991) (236)
Role of the retinoic acid receptor beta (RARbeta) during mouse development. (1997) (235)
Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study. (2008) (235)
Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance (2013) (235)
Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications. (2017) (234)
Retinoic Acid Controls the Bilateral Symmetry of Somite Formation in the Mouse Embryo (2005) (234)
Organisation and sequences at the 5′ end of a cloned complete ovalbumin gene (1979) (233)
The N‐terminal DNA‐binding ‘zinc finger’ of the oestrogen and glucocorticoid receptors determines target gene specificity. (1988) (232)
The HeLa cell protein TEF-1 binds specifically and cooperatively to two SV40 enhancer motifs of unrelated sequence (1988) (231)
Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter (1986) (231)
Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development (2002) (229)
The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system (2003) (228)
Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERβ-null mutant (2008) (228)
Differential expression of retinoid receptors in the adult mouse central nervous system (1999) (228)
Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development (2001) (227)
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. (2004) (226)
RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable. (1996) (223)
Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse. (2002) (217)
hSP, the domain‐duplicated homolog of pS2 protein, is co‐expressed with pS2 in stomach but not in breast carcinoma. (1990) (217)
Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissues (1990) (217)
Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. (2005) (216)
Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches. (2000) (216)
Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning. (1997) (215)
A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter. (1991) (215)
A G-Protein-Coupled Estrogen Receptor Is Involved in Hypothalamic Control of Energy Homeostasis (2006) (213)
Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development. (2000) (212)
Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions (2013) (211)
Peroxisome Proliferator-Activated Receptor (PPAR)-β/δ Stimulates Differentiation and Lipid Accumulation in Keratinocytes (2004) (210)
Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein (1997) (210)
Regulation of dopaminergic pathways by retinoids: activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family. (1997) (210)
Stromelysin 3 belongs to a subgroup of proteinases expressed in breast carcinoma fibroblastic cells and possibly implicated in tumor progression. (1993) (209)
Mice bearing deletions of retinoic acid receptors demonstrate reduced lung elastin and alveolar numbers. (2000) (209)
The patterns of binding of RAR, RXR and TR homo‐ and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains. (1993) (208)
In vivo activation of PPAR target genes by RXR homodimers (2004) (206)
Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements. (1994) (206)
Two distinct actions of retinoid-receptor ligands (1996) (205)
Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis. (1992) (203)
Retinoic acid receptor gene expression in human skin. (1991) (203)
Prediction of relapse and survival in breast cancer patients by pS2 protein status. (1990) (202)
Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand (2012) (202)
The chicken progesterone receptor: sequence, expression and functional analysis. (1987) (200)
Rapid modulation of long‐term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons (2007) (200)
Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element. (1991) (200)
Physical and Functional Interactions between Cellular Retinoic Acid Binding Protein II and the Retinoic Acid-Dependent Nuclear Complex (1999) (199)
The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements (1983) (199)
ATP-driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR/RXR In vitro. (2000) (198)
Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes. (2001) (197)
Hoxa2 and Hoxb2 Control Dorsoventral Patterns of Neuronal Development in the Rostral Hindbrain (1999) (196)
The nuclear receptor superfamily: a personal retrospect on the first two decades. (2005) (196)
Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid. (1995) (196)
AP-2.2, a novel gene related to AP-2, is expressed in the forebrain, limbs and face during mouse embryogenesis (1996) (195)
Chicken oviduct progesterone receptor: Location of specific regions of high-affinity binding in cloned DNA fragments of hormone-responsive genes (1982) (194)
Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors. (1993) (193)
Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation. (2004) (192)
Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis (2002) (192)
Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis (2012) (190)
The AF-1 activation-function of ERα may be dispensable to mediate the effect of estradiol on endothelial NO production in mice (2002) (189)
Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse. (1999) (189)
STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation (2008) (188)
Expanded CTG repeats within the DMPK 3′ UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy (2008) (187)
Chromatin remodelling complex dosage modulates transcription factor function in heart development (2011) (186)
Mouse P450RAI (CYP26) Expression and Retinoic Acid-inducible Retinoic Acid Metabolism in F9 Cells Are Regulated by Retinoic Acid Receptor γ and Retinoid X Receptor α* (1998) (186)
A yeast activity can substitute for the HeLa cell TATA box factor (1988) (186)
Estradiol Alters Nitric Oxide Production in the Mouse Aorta Through the α-, but not β-, Estrogen Receptor (2002) (186)
Transcriptional enhancer factor (TEF)‐1 and its cell‐specific co‐activator activate human papillomavirus‐16 E6 and E7 oncogene transcription in keratinocytes and cervical carcinoma cells. (1992) (186)
Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins. (1974) (186)
Is actin a transcription initiation factor for RNA polymerase B? (1984) (186)
Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand (1995) (185)
The SV40 early region TATA box is required for accurate in vitro initiation of transcription (1981) (185)
Purification and interaction properties of the human RNA polymerase B(II) general transcription factor BTF2. (1991) (184)
Retinoid X receptors are essential for early mouse development and placentogenesis. (1999) (182)
Genomewide production of multipurpose alleles for the functional analysis of the mouse genome. (2005) (182)
Temporal regulation of Cre recombinase activity in neural stem cells (2006) (181)
Structure of transcribing chromatin. (1980) (180)
Neoplastic progression of human colorectal cancer is associated with overexpression of the stromelysin‐3 and BM‐40/SPARC genes (1995) (180)
Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma (2009) (180)
Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin. (1994) (179)
Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). (1995) (178)
Repression of the immunoglobulin heavy chain enhancer by the adenovirus-2 E1A products. (1985) (178)
Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract. (1991) (178)
RARγ is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation (2006) (175)
Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes. (1990) (173)
Widely spaced, directly repeated PuGGTCA elements act as promiscuous enhancers for different classes of nuclear receptors (1995) (172)
Distinct TFIID complexes mediate the effect of different transcriptional activators. (1993) (171)
Biochemical evidence of variability in the DNA repeat length in the chromatin of higher eukaryotes. (1976) (170)
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells (2011) (170)
PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes. (2006) (169)
Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2. (1997) (168)
Cloning of the chicken progesterone receptor. (1986) (166)
Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes. (1997) (166)
Cooperativity and hierarchical levels of functional organization in the SV40 enhancer (1988) (164)
EMPReSS: standardized phenotype screens for functional annotation of the mouse genome (2005) (162)
Loss of Trim24 (Tif1α) gene function confers oncogenic activity to retinoic acid receptor alpha (2007) (161)
The ovalbumin gene family: Hormonal control of X and Y gene transcription and mRNA accumulation (1981) (160)
Phosphorylation by p38MAPK and recruitment of SUG‐1 are required for RA‐induced RARγ degradation and transactivation (2002) (160)
Retinoids Regulate Survival and Antigen Presentation by Immature Dendritic Cells (2003) (160)
The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoter. (1983) (160)
Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice. (1995) (160)
Synergy between estrogen receptor α activation functions AF1 and AF2 mediated by transcription intermediary factor TIF2 (2000) (159)
Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism (1995) (158)
Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. (2003) (158)
Efficient temporally‐controlled targeted mutagenesis in smooth muscle cells of the adult mouse (2009) (158)
Function of the retinoic acid receptors (RARs) during development .2. Multiple abnormalities at vari (1994) (157)
Identification of a novel retinoic acid receptor in regenerative tissues of the newt (1989) (156)
NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines. (2001) (155)
Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton. (1996) (155)
Developmental roles of the retinoic acid receptors (1995) (154)
SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells (1997) (153)
The complete nucleotide sequence of the chicken ovotransferrin mRNA. (1982) (152)
Dimerization with Retinoid X Receptors and Phosphorylation Modulate the Retinoic Acid-induced Degradation of Retinoic Acid Receptors α and γ through the Ubiquitin-Proteasome Pathway* (2000) (151)
Hypoxia‐inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis (2011) (151)
Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice (2003) (149)
Induction of altered chromatin structures by simian virus 40 enhancer and promoter elements (1984) (147)
The 28-kDa N-terminal domain of mouse stromelysin-3 has the general properties of a weak metalloproteinase. (1993) (146)
Non-cell-autonomous retinoid signaling is crucial for renal development (2010) (146)
Vitamin D receptor in osteoblasts is a negative regulator of bone mass control. (2013) (145)
Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes. (2001) (145)
Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse (2004) (145)
Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment. (1993) (144)
TIF1γ, a novel member of the transcriptional intermediary factor 1 family (1999) (144)
Retinoic Acid Receptor β2 (RARβ2) Null Mutant Mice Appear Normal (1994) (144)
Transgenic mice for conditional gene manipulation in astroglial cells (2007) (144)
Specific in vitro initiation of transcription on conalbumin and ovalbumin genes and comparison with adenovirus-2 early and late genes (1980) (143)
Brg1 is required for murine neural stem cell maintenance and gliogenesis. (2006) (143)
RXRalpha‐null F9 embryonal carcinoma cells are resistant to the differentiation, anti‐proliferative and apoptotic effects of retinoids. (1996) (143)
Cell‐specific activity of a GGTCA half‐palindromic oestrogen‐responsive element in the chicken ovalbumin gene promoter. (1988) (142)
HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis (2013) (140)
The cellular retinoic acid binding protein I is dispensable. (1994) (140)
Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms. (1990) (140)
Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells. (1997) (139)
Estrogen promotes cutaneous wound healing via estrogen receptor β independent of its antiinflammatory activities (2010) (138)
The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers. (1994) (138)
Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice. (2011) (137)
Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome (2015) (136)
Specific interaction between a transcription factor and the upstream element of the adenovirus‐2 major late promoter. (1985) (135)
Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis. (1999) (135)
Organisation and sequence studies of the 17-piece chicken conalbumin gene (1979) (134)
Cell-type specific protein binding to the enhancer of simian virus 40 in nuclear extracts (1986) (134)
Physiological and retinoid‐induced proliferations of epidermis basal keratinocytes are differently controlled (2002) (133)
The late retinoic acid induction of laminin B1 gene transcription involves RAR binding to the responsive element. (1991) (132)
Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. (1989) (132)
Common Properties of Nuclear Body Protein SP100 and TIF1α Chromatin Factor: Role of SUMO Modification (2001) (132)
A mutation mimicking ligand‐induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers (1997) (132)
Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos. (1993) (131)
Expression of nuclear retinoic acid receptors in normal tracheobronchial cells and in lung carcinoma cells. (1991) (130)
The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development. (1998) (130)
Developmental abnormalities in cultured mouse embryos deprived of retinoic by inhibition of yolk-sac retinol binding protein synthesis. (1996) (130)
A single amino acid that determines the sensitivity of progesterone receptors to RU486. (1992) (129)
Animal DNA-dependent RNA polymerases. 4. Studies on inhibition by rifamycin derivatives. (1972) (129)
Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin. (2009) (129)
Estradiol Accelerates Reendothelialization in Mouse Carotid Artery Through Estrogen Receptor-&agr; but Not Estrogen Receptor-&bgr; (2001) (129)
A general transcription factor forms a stable complex with RNA polymerase B (II) (1987) (128)
Conformational adaptation of agonists to the human nuclear receptor RARγ (1998) (128)
pS2 expression and response to hormonal therapy in patients with advanced breast cancer. (1991) (128)
Tissue-specific expression of retinoic acid receptor isoform transcripts in the mouse embryo (2000) (127)
Retinoic Acid Receptors Interact Physically and Functionally with the T:G Mismatch-specific Thymine-DNA Glycosylase* (1998) (127)
A genetic dissection of the retinoid signalling pathway in the mouse (1999) (126)
Human skin levels of retinoic acid and cytochrome P-450-derived 4-hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor-mediated transcription in vitro. (1992) (126)
The DNA repeat lengths in chromatins from sea urchin sperm and gastrula cells are markedly different (1976) (125)
Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes. (2001) (124)
Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells (1997) (124)
Role of nuclear retinoic acid receptors in the regulation of gene expression. (1994) (124)
Clustering of RNA polymerase B molecules in the 5' moiety of the adult beta-globin gene of hen erythrocytes. (1981) (123)
AP-2.2: a novel AP-2-related transcription factor induced by retinoic acid during differentiation of P19 embryonal carcinoma cells. (1996) (123)
Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning. (2001) (123)
Retinoic acid receptor-beta: an endogenous inhibitor of the perinatal formation of pulmonary alveoli. (2000) (123)
Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo. (1995) (123)
Characterization of the estrogen-induced pS2 protein secreted by the human breast cancer cell line MCF-7. (1987) (123)
Estradiol alters nitric oxide production in the mouse aorta through the alpha-, but not beta-, estrogen receptor. (2002) (122)
The N‐terminal domain of the human TATA‐binding protein plays a role in transcription from TATA‐containing RNA polymerase II and III promoters. (1994) (122)
The molecular and genetic dissection of the retinoid signaling pathway. (1995) (122)
Retinaldehyde dehydrogenase 2 (RALDH2)- independent patterns of retinoic acid synthesis in the mouse embryo (2002) (122)
Retinal dysplasia and degeneration in RARbeta2/RARgamma2 compound mutant mice. (1996) (122)
Stimulation of in vitro transcription from the SV40 early promoter by the enhancer involves a specific trans‐acting factor. (1984) (122)
Subunit structure of simian-virus-40 minichromosome. (1976) (121)
The Targeted Disruption of Both Alleles of RARβ2 in F9 Cells Results in the Loss of Retinoic Acid-associated Growth Arrest* (1999) (120)
Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. (1995) (119)
Promoter elements of genes coding for proteins and modulation of transcription by estrogens and progesterone. (1984) (119)
CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse. (2007) (119)
Defects of the Chorioallantoic Placenta in Mouse RXRα Null Fetuses (1997) (118)
Specific in vitro transcription of conalbumin gene is drastically decreased by single-point mutation in T-A-T-A box homology sequence. (1980) (118)
Mouse functional genomics requires standardization of mouse handling and housing conditions (2004) (118)
Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes. (2006) (118)
Summary: the molecular biology of the eukaryotic genome is coming of age. (1978) (118)
The ovalbumin gene region: common features in the organisation of three genes expressed in chicken oviduct under hormonal control (1979) (117)
Defining a minimal estrogen receptor DNA binding domain. (1993) (117)
T:G Mismatch-specific Thymine-DNA Glycosylase Potentiates Transcription of Estrogen-regulated Genes through Direct Interaction with Estrogen Receptor α* (2003) (117)
Immunodetection of multiple species of retinoic acid receptor α : evidence for phosphorylation (1992) (117)
Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RAR beta 2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. (1996) (117)
A trans-acting factor is responsible for the simian virus 40 enhancer activity in vitro (1985) (117)
Breast-cancer-associated stromelysin-3 gene is expressed in basal cell carcinoma and during cutaneous wound healing. (1992) (117)
Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods. (1999) (116)
Hedgehog signaling regulates sebaceous gland development. (2003) (116)
Retinoids regulate the anterior expression boundaries of 5′ Hoxb genes in posterior hindbrain (2003) (115)
Phosphorylation of the retinoic acid receptor-alpha by protein kinase A. (1995) (115)
Transcription Coactivator PBP, the Peroxisome Proliferator-activated Receptor (PPAR)-binding Protein, Is Required for PPARα-regulated Gene Expression in Liver* (2004) (115)
Steroid Receptor Coactivator 2 Is Critical for Progesterone-Dependent Uterine Function and Mammary Morphogenesis in the Mouse (2006) (114)
Postnatal Tissue-specific Disruption of Transcription Factor FoxN1 Triggers Acute Thymic Atrophy* (2009) (114)
Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. (2004) (114)
Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure (2007) (113)
Phosphorylation on tyrosine of in vitro synthesized human estrogen receptor activates its hormone binding. (1989) (113)
Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice. (1995) (113)
Phosphorylation of activation functions AF‐1 and AF‐2 of RARα and RARγ is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment (1997) (112)
Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells (2006) (112)
Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction. (2002) (112)
Animal DNA-dependent RNA polymerases. Studies on the binding of mammalian RNA polymerases AI and B to Simian virus 40 DNA. (1974) (112)
Meis2, a novel mouse Pbx‐related homeobox gene induced by retinoic acid during differentiation of P19 embryonal carcinoma cells (1997) (112)
The transactivating function 1 of estrogen receptor α is dispensable for the vasculoprotective actions of 17β-estradiol (2009) (111)
Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation (2005) (111)
Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation. (2004) (111)
Activation function 2 (AF2) of estrogen receptor-α is required for the atheroprotective action of estradiol but not to accelerate endothelial healing (2011) (111)
Luminal cells are favored as the cell of origin for prostate cancer. (2014) (110)
Differential regulation of retinoic acid receptors and binding proteins in human skin. (1992) (110)
A chimeric Cre recombinase inducible by synthetic,but not by natural ligands of the glucocorticoid receptor. (1998) (109)
RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codon. (1992) (109)
Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast. (1992) (109)
The acidic transcriptional activator GAL‐VP16 acts on preformed template‐committed complexes. (1992) (109)
Vaccination against tumor cells expressing breast cancer epithelial tumor antigen. (1990) (109)
Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling. (2006) (109)
Retinoic Acid Signaling Affects Cortical Synchrony During Sleep (2005) (108)
Conserved interaction between distinct Krüppel-associated box domains and the transcriptional intermediary factor 1 beta. (2001) (108)
TFIIH Interacts with the Retinoic Acid Receptor γ and Phosphorylates Its AF-1-activating Domain through cdk7* (2000) (107)
A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid (1996) (107)
Sequencing and expression of complementary DNA for the general transcription factor BTF3 (1990) (107)
DNA methylation: correlation with DNase I sensitivity of chicken ovalbumin and conalbumin chromatin. (1979) (107)
Cloning of the 62-kilodalton component of basic transcription factor BTF2. (1992) (107)
Segmentation and specification in the branchial region of the head: the role of the Hox selector genes. (1998) (106)
Retinoic acid-induced developmental defects are mediated by RARβ/RXR heterodimers in the pharyngeal endoderm (2003) (106)
Retinoic acid receptor gamma: specific immunodetection and phosphorylation (1991) (106)
Stromelysin-3 gene expression in human cancer: an overview. (1994) (106)
Structure of the human oestrogen-responsive gene pS2. (1987) (105)
Sequence and expression pattern of the Stra7 (Gbx‐2) homeobox‐containing gene induced by retinoic acid in P19 embryonal carcinoma cells (1995) (105)
Mechanisms of antihormone action (1992) (104)
The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin. (1999) (104)
Stimulus-selective induction of CRABP-II mRNA: a marker for retinoic acid action in human skin. (1993) (104)
Working memory deficits in retinoid X receptor gamma-deficient mice. (2005) (104)
Selective interaction between the chromatin‐remodeling factor BRG1 and the heterochromatin‐associated protein HP1α (2002) (103)
Animal DNA-dependent RNA polymerases. 3. Purification of calf-thymus BI and BII enzymes. (1972) (103)
Amino acid-dependent activation of liver estrogen receptor alpha integrates metabolic and reproductive functions via IGF-1. (2011) (103)
In vitro binding of cell‐specific and ubiquitous nuclear proteins to the octamer motif of the SV40 enhancer and related motifs present in other promoters and enhancers. (1987) (103)
Effect of histone acetylation on structure and in vitro transcription of chromatin. (1978) (102)
Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types. (1995) (102)
In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries. (1996) (102)
Developmental expression of mouse stromelysin-3 mRNA. (1995) (102)
Modulation by retinoic acid (RA) of squamous cell differentiation, cellular RA-binding proteins, and nuclear RA receptors in human head and neck squamous cell carcinoma cell lines. (1994) (101)
Cloning of the gene encoding the yeast protein BTF1Y, which can substitute for the human TATA box-binding factor. (1989) (101)
Targeted Somatic Mutagenesis in Mouse Epidermis (2001) (100)
Estrogen receptor-alpha promotes alternative macrophage activation during cutaneous repair. (2014) (99)
Estrogen receptor alpha is a major contributor to estrogen-mediated fetal testis dysgenesis and cryptorchidism. (2007) (98)
Tumour prevention and rejection with recombinant vaccinia (1987) (98)
Purification and Properties of Calf Thymus DNA-Dependent RNA Polymerases A and B (1970) (97)
Nucleosome structure III: the structure and transcriptional activity of the chromatin containing the ovalbumin and globin genes in chick oviduct nuclei. (1978) (97)
Sequences upstream from the T-A-T-A box are required in vivo and in vitro for efficient transcription from the adenovirus serotype 2 major late promoter. (1982) (96)
In vitro binding of several cell-specific and ubiquitous nuclear proteins to the GT-I motif of the SV40 enhancer. (1987) (96)
Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit betaFTZ-F1-dependent transcription. (2001) (96)
Properties of a purified estradiol-dependent calf uterus tyrosine kinase. (1993) (95)
Hyperphosphorylation of the Retinoid X Receptor α by Activated c-Jun NH2-terminal Kinases* (1999) (95)
Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma (2008) (95)
Endogenous Retinoic Acid Receptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regulating Retinoid-responsive Elements in Adult Human Keratinocytes (1995) (94)
Specific protein binding to the simian virus 40 enhancer in vitro (1986) (94)
Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level. (1984) (94)
Animal DNA-dependent RNA polymerases. Molecular structures and immunological properties of calf-thymus enzyme AI and of calf-thymus and rat-liver enzymes B. (1974) (93)
The transcriptional activation function located in the hormone‐binding domain of the human oestrogen receptor is not encoded in a single exon. (1989) (93)
Roles of transactivating functions 1 and 2 of estrogen receptor-α in bone (2011) (93)
Animal DNA-dependent RNA polymerases. 1. Large-scale solubilization and separation of A and B calf-thymus RNA-polymerase activities. (1972) (93)
The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression (1993) (93)
Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma. (1993) (93)
Retinoid X receptor alpha forms tetramers in solution. (1995) (93)
IL‐13 induces expression of CD36 in human monocytes through PPARγ activation (2007) (92)
Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes. (2007) (92)
The expression pattern of the mouse receptor tyrosine kinase gene MDK1 is conserved through evolution and requires Hoxa-2 for rhombomere-specific expression in mouse embryos. (1996) (92)
Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis. (2016) (92)
Shifting the feeding of mice to the rest phase creates metabolic alterations, which, on their own, shift the peripheral circadian clocks by 12 hours (2015) (92)
Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. (2006) (92)
Myocytic androgen receptor controls the strength but not the mass of limb muscles (2010) (92)
Estrogen receptor‐α is associated with the plasma membrane of astrocytes and coupled to the MAP/Src‐kinase pathway (2005) (91)
The ovalbumin gene family: Structure of the X gene and evolution of duplicated split genes (1980) (91)
Thyroid hormone resistance and increased metabolic rate in the RXR-γ–deficient mouse (2000) (91)
Impaired Granulocytic Differentiation In Vitro in Hematopoietic Cells Lacking Retinoic Acid Receptors α1 and γ (1998) (91)
Specific and Redundant Functions of Retinoid X Receptor/Retinoic Acid Receptor Heterodimers in Differentiation, Proliferation, and Apoptosis of F9 Embryonal Carcinoma Cells (1997) (90)
Stability of nucleosomes in native and reconstituted chromatins. (1976) (90)
Stromal estrogen receptor-α promotes tumor growth by normalizing an increased angiogenesis. (2012) (90)
A third human retinoic acid receptor , hRAR-y ( skin / nuclear receptors / vitamin A / transcriptional activation ) (90)
The Family of Retinoic Acid Nuclear Receptors (1991) (90)
Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene. (2006) (89)
Retinoic acid signalling in the development of branchial arches. (2004) (89)
Absence of Estrogen Receptor Alpha Leads to Physiological Alterations in the Mouse Epididymis and Consequent Defects in Sperm Function1 (2010) (89)
Retinaldehyde dehydrogenase 2 and Hoxc8 are required in the murine brachial spinal cord for the specification of Lim1+ motoneurons and the correct distribution of Islet1+ motoneurons (2005) (88)
Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse (2005) (88)
Characterization of the transcription activation function and the DNA binding domain of transcriptional enhancer factor‐1. (1993) (88)
Selective ablation of retinoid X receptor α in hepatocytes impairs their lifespan and regenerative capacity (2001) (88)
Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications (2011) (88)
An enhancer element is located 340 base pairs upstream from the adenovirus-2 E1A capsite. (1983) (87)
Stage-dependent responses of the developing lung to retinoic acid signaling. (2000) (87)
Negative control of Smad activity by ectodermin/Tif1γ patterns the mammalian embryo (2010) (87)
Retinoic acid induction of human cellular retinoic acid-binding protein-II gene transcription is mediated by retinoic acid receptor-retinoid X receptor heterodimers bound to one far upstream retinoic acid-responsive element with 5-base pair spacing. (1994) (87)
Structural and functional domains of the estrogen receptor. (1986) (87)
The influence of ionic strength and a polyanion on transcription in vitro. I. Stimulation of the aggregate RNA polymerase from rat liver nuclei. (1968) (87)
Estrogen Receptor α Signaling in Inflammatory Leukocytes Is Dispensable for 17β-Estradiol-Mediated Inhibition of Experimental Autoimmune Encephalomyelitis1 (2004) (86)
Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate. (2011) (86)
Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. (1999) (86)
Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2 (2013) (86)
Retinoic acid and synthetic analogs differentially activate retinoic acid receptor dependent transcription. (1990) (86)
Deletions covering the putative promoter region of early mRNAs of simian virus 40 do not abolish T-antigen expression. (1980) (86)
A new version of the two-hybrid assay for detection of protein-protein interactions. (1995) (85)
Genetic interactions of Hox genes in limb development: learning from compound mutants. (1997) (85)
Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1 (2003) (85)
Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes. (1991) (85)
Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors. (1996) (84)
Retinoid receptors in vertebrate limb development. (1992) (84)
TIF1δ, a Novel HP1-interacting Member of the Transcriptional Intermediary Factor 1 (TIF1) Family Expressed by Elongating Spermatids* (2004) (84)
A superfamily of potentially oncogenic hormone receptors. (1986) (83)
Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. (2009) (83)
Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse (1997) (83)
Prevention of Obesity and Insulin Resistance by Estrogens Requires ERα Activation Function-2 (ERαAF-2), Whereas ERαAF-1 Is Dispensable (2013) (82)
Direct crossregulation between retinoic acid receptor β and Hox genes during hindbrain segmentation (2005) (82)
Retinoids and spermatogenesis: Lessons from mutant mice lacking the plasma retinol binding protein (2006) (82)
Expression of the pS2 gene in normal, benign and neoplastic human stomach (1989) (82)
TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. (1999) (81)
Retinoic acid receptor belongs to a subclass of nuclear receptors that do not form "docking" complexes with hsp90. (1991) (81)
A single-stranded DNA-binding protein promotes the binding of the purified oestrogen receptor to its responsive element. (1990) (81)
Retinoic acid receptor-beta: immunodetection and phosphorylation on tyrosine residues. (1992) (81)
SUG1, a Putative Transcriptional Mediator and Subunit of the PA700 Proteasome Regulatory Complex, Is a DNA Helicase* (1997) (81)
Temporally controlled targeted somatic mutagenesis in the mouse brain (2001) (80)
F9 embryocarcinoma cells: a cell autonomous model to study the functional selectivity of RARs and RXRs in retinoid signaling. (2001) (80)
Insertion of a targeting construct in a Hoxd‐10 allele can influence the control of Hoxd‐9 expression (1994) (80)
Rearrangement of chromatin structure induced by increasing ionic strength and temperature. (1979) (80)
The mouse immunoglobulin heavy‐chain enhancer: effect on transcription in vitro and binding of proteins present in HeLa and lymphoid B cell extracts. (1986) (80)
Estrogen Receptor α, but Not β, Is Required for Optimal Dendritic Cell Differentiation and CD40-Induced Cytokine Production1 (2008) (79)
One cell‐specific and three ubiquitous nuclear proteins bind in vitro to overlapping motifs in the domain B1 of the SV40 enhancer. (1987) (79)
RORα-expressing T regulatory cells restrain allergic skin inflammation (2018) (79)
SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity. (2009) (79)
Estradiol Promotes Functional Responses in Inflammatory and Steady-State Dendritic Cells through Differential Requirement for Activation Function-1 of Estrogen Receptor α (2013) (79)
p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells (2014) (79)
The molecular and genetic dissection of the retinoid signalling pathway. (1993) (78)
Detection of retinoid X receptors using specific monoclonal and polyclonal antibodies. (1994) (78)
Epididymal Hypo-Osmolality Induces Abnormal Sperm Morphology and Function in the Estrogen Receptor Alpha Knockout Mouse1 (2010) (77)
Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction (2009) (77)
The role of estrogen receptor α in growth plate cartilage for longitudinal bone growth (2010) (76)
All six GC‐motifs of the SV40 early upstream element contribute to promoter activity in vivo and in vitro. (1985) (76)
Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction. (2004) (75)
Animal DNA-dependent RNA polymerases. 12. Determination of the cellular number of RNA polymerase B molecules. (1974) (75)
Complete structure of the human transferrin gene. Comparison with analogous chicken gene and human pseudogene. (1987) (75)
Animal DNA-dependent RNA polymerases. 2. Purification of calf-thymus AI enzyme. (1972) (75)
Ligand- and DNA-induced dissociation of RXR tetramers. (1998) (75)
The Putative Cofactor TIF1α Is a Protein Kinase That Is Hyperphosphorylated upon Interaction with Liganded Nuclear Receptors* (1998) (75)
Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouse. (2002) (75)
The pS2 gene, mRNA, and protein: a potential marker for human breast cancer. (1990) (74)
The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells (2012) (74)
General repression of enhanson activity by the adenovirus-2 E1A proteins. (1990) (74)
Efficient transactivation by retinoic acid receptors in yeast requires retinoid X receptors. (1993) (74)
Skeletal Effects of Estrogen Are Mediated by Opposing Actions of Classical and Nonclassical Estrogen Receptor Pathways (2005) (73)
A mutated polyoma virus enhancer which is active in undifferentiated embryonal carcinoma cells is not repressed by adenovirus-2 E1A products (1986) (73)
Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex (2015) (73)
Differences in Gene Expression between Wild Type and Hoxa1 Knockout Embryonic Stem Cells after Retinoic Acid Treatment or Leukemia Inhibitory Factor (LIF) Removal* (2005) (73)
A highly conserved region in the hormone-binding domain of the human estrogen receptor functions as an efficient transactivation domain in yeast. (1994) (73)
Ligand‐dependent contribution of RXRβ to cholesterol homeostasis in Sertoli cells (2004) (72)
Different TBP-associated factors are required for mediating the stimulation of transcription in vitro by the acidic transactivator GAL- VP16 and the two nonacidic activation functions of the estrogen receptor (1993) (72)
Progestin receptors: Isoforms and antihormone action (1991) (72)
Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse. (1989) (71)
Retinoic acid receptor-α regulates pulmonary alveolus formation in mice after, but not during, perinatal period (2003) (70)
Oligonucleotide-directed mutagenesis by microscale 'shot-gun' gene synthesis. (1985) (70)
A conditional floxed (loxP‐flanked) allele for the retinoic acid receptor gamma (RARγ) gene (2002) (69)
Transcription by eukaryotic RNA polymerases A and B of chromatin assembled in vitro. (1979) (69)
Cloning of the human glucocorticoid receptor cDNA. (1985) (69)
Modulation by retinoids of mRNA levels for nuclear retinoic acid receptors in murine melanoma cells. (1990) (68)
Organization of coding and intervening sequences in the chicken ovalbumin split gene (1978) (68)
The yeast Ada complex mediates the ligand-dependent activation function AF-2 of retinoid X and estrogen receptors. (1998) (68)
Structure and expression of the mouse beta 2‐microglobulin gene isolated from somatic and non‐expressing teratocarcinoma cells. (1983) (67)
Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily. (1998) (67)
Animal DNA-dependent RNA polymerases. Initiation sites on calf-thymus DNA. (1973) (67)
GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression (2015) (67)
Nuclear Detection of Cellular Retinoic Acid Binding Proteins I and II with New Antibodies (1998) (67)
Animal DNA-dependent RNA polymerases. Studies on the reaction parameters of transcription in vitro of Simian virus 40 DNA by mammalian RNA polymerases AI and B. (1974) (66)
Association of the human spasmolytic polypeptide and an estrogen-induced breast cancer protein (pS2) with human pancreatic carcinoma. (1992) (66)
Transcription of in vitro assembled chromatin by Escherichia coli RNA polymerase. (1979) (65)
Hoxa1 and Krox-20 synergize to control the development of rhombomere 3. (1998) (65)
Theca-specific estrogen receptor-alpha knockout mice lose fertility prematurely. (2009) (65)
Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. (2015) (64)
Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid. (2000) (63)
Expression of active hormone and DNA‐binding domains of the chicken progesterone receptor in E. coli. (1989) (63)
Insulin-like growth factor-1 promotes wound healing in estrogen-deprived mice: new insights into cutaneous IGF-1R/ERα cross talk. (2012) (63)
Suprabasal expression of a dominant-negative RXR alpha mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids. (1997) (63)
Short and long range activation by the SV40 enhancer. (1984) (63)
Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation. (2009) (62)
Identification of heparin‐binding EGF‐like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors (1999) (62)
TGF-beta superfamily signaling is essential for tooth and hair morphogenesis and differentiation. (2007) (62)
RARβ isoforms: distinct transcriptional control by retinoic acid and specific spatial patterns of promoter activity during mouse embryonic development (1994) (62)
The ulceration‐associated cell lineage (UACL) reiterates the Brunner's gland differentiation programme but acquires the proliferative organization of the gastric gland (1994) (61)
Purification of RNA polymerase B activity from rat liver (1971) (61)
Modular patterning of structure and function of the striatum by retinoid receptor signaling (2008) (61)
A soluble DNA-dependent RNA polymerase in nuclei of non-dividing animal cells (1965) (61)
Differential nuclease sensitivity of the ovalbumin and beta-globin chromatin regions in erythrocytes and oviduct cells of laying hen. (1980) (61)
Antibodies specific to the retinoic acid human nuclear receptors alpha and beta. (1989) (61)
Molecular cloning of extensive sequences of the in vitro synthesized chicken ovalbumin structural gene. (1977) (60)
Pituitary Gonadotroph Estrogen Receptor-α Is Necessary for Fertility in Females (2008) (60)
Impaired granulocytic differentiation in vitro in hematopoietic cells lacking retinoic acid receptors alpha1 and gamma. (1998) (60)
Tripartite Motif 24 (Trim24/Tif1α) Tumor Suppressor Protein Is a Novel Negative Regulator of Interferon (IFN)/Signal Transducers and Activators of Transcription (STAT) Signaling Pathway Acting through Retinoic Acid Receptor α (Rarα) Inhibition* (2011) (60)
An efficient system for conditional gene expression in embryonic stem cells and in their in vitro and in vivo differentiated derivatives (2001) (60)
Identification and characterization of retinoic acid receptor beta2 target genes in F9 teratocarcinoma cells. (2003) (59)
Animal DNA-dependent RNA polymerases. Partial purification and properties of three classes of RNA polymerases from uninfected and adenovirus-infected HeLa cells. (1975) (59)
Retinoic acid receptors and binding proteins in human skin. (1992) (59)
Stimulation of in vitro transcription by the upstream element of the adenovirus-2 major late promoter involves a specific factor. (1984) (59)
Role of foxj1 and estrogen receptor alpha in ciliated epithelial cell differentiation of the neonatal oviduct. (2004) (59)
Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation (2010) (59)
Animal DNA-dependent RNA polymerases. 10. General enzymatic properties of purified calf thymus RNA polymerases AI and B. (1974) (59)
The transactivating function-1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17 beta-estradiol. (2009) (58)
Stromelysin‐3 in stromal tissue as a control factor in breast cancer behavior (1994) (58)
Pure and functionally homogeneous recombinant retinoid X receptor. (1994) (58)
Site-specific somatic mutagenesis in the retinal pigment epithelium. (2002) (58)
Effects of Diethylstilbestrol on Programmed Oocyte Death and Induction of Polyovular Follicles in Neonatal Mouse Ovaries1 (2009) (58)
Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha). (1990) (58)
Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease. (2006) (57)
RXRα overexpression in cardiomyocytes causes dilated cardiomyopathy but fails to rescue myocardial hypoplasia in RXRα-null fetuses (2000) (57)
9. Eucaryotic RNA Polymerases (1974) (57)
Variegated chromatin structures of mouse ribosomal RNA genes (1983) (57)
Promotion of specific in vitro transcription by excised "TATA" box sequences inserted in a foreign nucleotide environment. (1981) (57)
Homo- and heterodimers of the retinoid X receptor (RXR) activated transcription in yeast. (1994) (57)
Cell-specific activity of the constituent elements of the simian virus 40 enhancer. (1987) (56)
The effect of partial hepatectomy on the ribonucleic acid polymerase of rat liver. (1962) (56)
The template of the isolated native simian virus 40 transcriptional complexes is a minichromosome. (1979) (56)
Contribution of retinoic acid receptor beta isoforms to the formation of the conotruncal septum of the embryonic heart. (1998) (56)
Regulation of CD8+ T Lymphocyte Effector Function and Macrophage Inflammatory Cytokine Production by Retinoic Acid Receptor γ1 (2007) (56)
Steroid hormone dependence of four DNase I‐hypersensitive regions located within the 7000‐bp 5′‐flanking segment of the ovalbumin gene. (1986) (56)
Expression of the breast cancer associated gene pS2 and the pancreatic spasmolytic polypeptide gene (hSP) in diffuse type of stomach carcinoma. (1991) (56)
Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice (2019) (55)
Retinoic Acid Signal Transduction Pathways a (1993) (55)
The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles. (2010) (55)
Mutational dissection of the 21 bp repeat region of the SV40 early promoter reveals that it contains overlapping elements of the early-early and late-early promoters. (1984) (54)
Female Mice Lacking Estrogen Receptor β Display Prolonged Ventricular Repolarization and Reduced Ventricular Automaticity After Myocardial Infarction (2005) (54)
Prevention of Skin Flap Necrosis by Estradiol Involves Reperfusion of a Protected Vascular Network (2009) (54)
BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease (2017) (54)
Differential contributions of AF-1 and AF-2 activities to the developmental functions of RXR alpha. (2001) (54)
Multiple Interactions between hTAFII55 and Other TFIID Subunits (1996) (54)
Retinoid X Receptor Gamma Is Implicated in Docosahexaenoic Acid Modulation of Despair Behaviors and Working Memory in Mice (2011) (54)
Stimulation of in vitro transcription from heterologous promoters by the simian virus 40 enhancer. (1984) (54)
Immunological similarity between the chick oviduct progesterone receptor forms A and B. (1985) (54)
Differential expression of retinoic acid-inducible (Stra) genes during mouse placentation (2000) (54)
Expression of the stromelysin-3 gene in fibroblastic cells of invasive carcinomas of the breast and other human tissues: a review (2005) (54)
Nizp1, a Novel Multitype Zinc Finger Protein That Interacts with the NSD1 Histone Lysine Methyltransferase through a Unique C2HR Motif (2004) (53)
Introduction of estrogen-responsiveness into mammalian cell lines. (1986) (53)
Relation between soluble DNA-dependent RNA polymerase and "aggregate" RNA polymerase. (1965) (53)
Estradiol-inducible squelching and cell growth arrest by a chimeric VP16-estrogen receptor expressed in Saccharomyces cerevisiae: suppression by an allele of PDR1 (1993) (52)
The SV40 TC‐II(kappa B) and the related H‐2Kb enhansons exhibit different cell type specific and inducible proto‐enhancer activities, but the SV40 core sequence and the AP‐2 binding site have no enhanson properties. (1989) (52)
Breast cancer protein PS2 synthesis in mammary gland of transgenic mice and secretion into milk. (1989) (52)
後脳におけるKrox‐20およびHox遺伝子発現の局所的変更は同型配偶子ヌルHoxa‐1(Hox‐1.6)突然変異はいの菱脳の神経小片4および5の欠損を示唆する (1993) (52)
Stage and tissue‐specific expression of the alcohol dehydrogenase 1 (Adh‐1) gene during mouse development (1994) (52)
The estrogen-responsive adrenomedullin and receptor-modifying protein 3 gene identified by DNA microarray analysis are directly regulated by estrogen receptor. (2006) (51)
Down-regulation of the Phosphatidylinositol 3-Kinase/Akt Pathway Is Involved in Retinoic Acid-induced Phosphorylation, Degradation, and Transcriptional Activity of Retinoic Acid Receptor γ2* (2002) (51)
TIF1alpha: a possible link between KRAB zinc finger proteins and nuclear receptors. (1998) (50)
In vitro activity of the transcription activation functions of the progesterone receptor. Evidence for intermediary factors. (1992) (50)
Characterization of multiple mRNAs originating from the chicken progesterone receptor gene. Evidence for a specific transcript encoding form A. (1990) (50)
Functions of RARs and RXRs in vivo: Genetic dissection of the retinoid signaling pathway (2003) (50)
Isolation by molecular cloning of a fragment of the split ovalbumin gene (1978) (50)
Transcription from the SV40 early‐early and late‐early overlapping promoters in the absence of DNA replication. (1983) (50)
Roles of retinoic acid receptors and of Hox genes in the patterning of the teeth and of the jaw skeleton. (1995) (50)
Effect of the 21‐bp repeat upstream element on in vitro transcription from the early and late SV40 promoters. (1984) (49)
Transcriptional regulation of retinoic acid receptor β in retinoic acid-sensitive and -resistant P19 embryocarcinoma cells (1991) (49)
T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif (2005) (49)
Characterization of adenovirus type 2 transcriptional complexes isolated from infected HeLa cell nuclei (1976) (49)
Mouse phenogenomics: the fast track to "systems metabolism". (2005) (49)
The SV40 TC‐II(kappa B) enhanson binds ubiquitous and cell type specifically inducible nuclear proteins from lymphoid and non‐lymphoid cell lines. (1989) (49)
The influence of ionic strength and a polyanion on transcription in vitro. II. Effects on the template efficiency of rat liver chromatin for a purified bacterial RNA polymerase. (1968) (48)
Functional alterations of the nigrostriatal dopamine system in estrogen receptor-α knockout (ERKO) mice (2008) (48)
Morphological and molecular characterization of retinoic acid-induced limb duplications in mice. (1996) (48)
Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer (2011) (48)
Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis. (2006) (48)
Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal. (1994) (47)
Nucleosome structure II: structure of the SV40 minichromosome and electron microscopic evidence for reversible transitions of the nucleosome structure. (1978) (47)
Cloning of an almost full-length chicken conalbumin double-stranded cDNA. (1979) (47)
Type II antagonists impair the DNA binding of steroid hormone receptors without affecting dimerization (1993) (47)
Immunodetection of multiple species of retinoic acid receptor alpha: evidence for phosphorylation. (1992) (47)
Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation. (2004) (47)
Aberrant Growth Plate Development in VDR/RXRγ Double Null Mutant Mice. (2001) (47)
Implication of retinoic acid receptor gamma in squamous differentiation and response to retinoic acid in head and neck SqCC/Y1 squamous carcinoma cells. (1996) (47)
Effects of neuron-specific estrogen receptor (ER) α and ERβ deletion on the acute estrogen negative feedback mechanism in adult female mice. (2014) (46)
A conditional floxed (loxP‐flanked) allele for the retinoic acid receptor alpha (RARα) gene (2002) (46)
Retinoid X Receptor γ-Deficient Mice Have Increased Skeletal Muscle Lipoprotein Lipase Activity and Less Weight Gain when Fed a High-Fat Diet (2004) (46)
Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7 (2010) (46)
Cell‐specificity of the chicken ovalbumin and conalbumin promoters. (1987) (45)
Ligand-dependent activation of transcription in vitro by retinoic acid receptor α/retinoid X receptor α heterodimers that mimics transactivation by retinoids in vivo (1999) (45)
Promoter Sequences ofEukaryotic Protein-Coding Genes (1980) (45)
Defects of the chorioallantoic placenta in mouse RXRalpha null fetuses. (1997) (45)
Role of ligand in retinoid signaling. 9-cis-retinoic acid modulates the oligomeric state of the retinoid X receptor. (1995) (45)
The role of estrogen receptor-α and its activation function-1 for growth plate closure in female mice. (2012) (44)
Alpha-amanitin: a specific inhibitor of one of two DNA-pendent RNA polymerase activities from calf thymus. (1970) (44)
In situ detection of retinoid‐X receptor expression in normal and psoriatic human skin (1995) (44)
Cell Autonomous Lipin 1 Function Is Essential for Development and Maintenance of White and Brown Adipose Tissue (2012) (44)
Standards of mouse model phenotyping (2006) (44)
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice. (2012) (44)
Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiency. (2002) (44)
All-trans retinoic acid induces cellular retinol-binding protein in human skin in vivo. (1995) (44)
Preferential in vitro assembly of nucleosome cores on some AT-rich regions of SV40 DNA. (1979) (44)
The Phosphorylation Site Located in the A Region of Retinoic X Receptor α Is Required for the Antiproliferative Effect of Retinoic Acid (RA) and the Activation of RA Target Genes in F9 Cells* (2002) (43)
Biochemical and electron-microscopic evidence that the subunit structure of Chinese-hamster-ovary interphase chromatin is conserved in mitotic chromosomes. (1976) (43)
Biochemical studies of bacterial sporulation and germination. X. Ribosomes and nucleic acids of vegetative cells and spores of Bacillus megaterium. (1968) (42)
Analysis of the visual cycle in cellular retinol-binding protein type I (CRBPI) knockout mice. (2002) (42)
A TATA-less Promoter Containing Binding Sites for Ubiquitous Transcription Factors Mediates Cell Type-specific Regulation of the Gene for Transcription Enhancer Factor-1 (TEF-1) (*) (1995) (42)
The AF-1 and AF-2 activating domains of retinoic acid receptor-alpha (RARalpha) and their phosphorylation are differentially involved in parietal endodermal differentiation of F9 cells and retinoid-induced expression of target genes. (2000) (42)
Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment. (1997) (42)
Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency. (2005) (42)
Expression of Sox9 in granulosa cells lacking the estrogen receptors, ERα and ERβ (2003) (42)
Estrogen Response Element-Independent Estrogen Receptor (ER)-α Signaling Does Not Rescue Sexual Behavior but Restores Normal Testosterone Secretion in Male ERα Knockout Mice (2007) (41)
Breast cancer-associated protein pS2 expression in tumors of the biliary tract. (1991) (41)
Digestion of the chicken beta‐globin gene chromatin with micrococcal nuclease reveals the presence of an altered nucleosomal array characterized by an atypical ladder of DNA fragments. (1986) (41)
Animal DNA-dependent RNA polymerases. Analysis of the RNAs synthesized on Simian virus 40 superhelical DNA by mammalian RNA polymerases AI and B. (1974) (41)
Evidence for two structurally related progesterone receptors in chick oviduct cytosol (1983) (40)
Contribution of cellular retinol‐binding protein type 1 to retinol metabolism during mouse development (2005) (40)
The Retinoic Acid Receptors α and β are Expressed in the Human Promyelocytic Leukemia Cell Line HL-60 (1989) (39)
The retinoic acid receptors RARα and RARγ are required for inner ear development (2002) (39)
Calf thymus RNA polymerases exhibit template specificity. (1970) (39)
Molecular cloning, genomic structure, and expression analysis of the mouse transcriptional intermediary factor 1 gamma gene. (2004) (39)
Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action. (2004) (39)
Far upstream sequences are required for efficient transcription from the adenovirus-2 E1A transcription unit. (1983) (39)
Biochemical studies of bacterial sporulation and germination. XI. Protein-synthesizing systems from vegetative cells and spores of Bacillus megaterium. (1968) (39)
Prokineticin Receptor 1 as a Novel Suppressor of Preadipocyte Proliferation and Differentiation to Control Obesity (2013) (39)
A transcriptionally silent RXRα supports early embryonic morphogenesis and heart development (2009) (39)
Retinoid receptors and binding proteins (1992) (39)
Disruption of the typical chromatin structure in a 2500 base‐pair region at the 5′ end of the actively transcribed ovalbumin gene. (1982) (39)
The inhibition of fat cell proliferation by n-3 fatty acids in dietary obese mice (2011) (38)
Ligand-dependent interaction of nuclear receptors with potential transcriptional intermediary factors (mediators). (1996) (38)
Effects of diethylstilbestrol on ovarian follicle development in neonatal mice. (2009) (38)
Identification of the molecular requirements for an RAR alpha-mediated cell cycle arrest during granulocytic differentiation. (2004) (38)
Functional role of RXRs and PPARγ in mature adipocytes (2005) (38)
Somatic ablation of the Lrat gene in the mouse retinal pigment epithelium drastically reduces its retinoid storage. (2007) (37)
A retinol-binding protein receptor-mediated mechanism for uptake of vitamin A to postimplantation rat embryos. (1997) (37)
A T to A base substitution and small deletions in the conalbumin TATA box drastically decrease specific in vitro transcription. (1981) (37)
Role of the essential yeast protein PSU1 in transcriptional enhancement by the ligand‐dependent activation function AF‐2 of nuclear receptors (1999) (37)
Switching agonistic, antagonistic, and mixed transcriptional responses to 11 beta-substituted progestins by mutation of the progesterone receptor. (1992) (37)
Mapping of the human retinoic acid receptor to the q21 band of chromosome 17 (1988) (37)
Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis. (2006) (36)
17beta-estradiol inhibits wound healing in male mice via estrogen receptor-alpha. (2010) (36)
The RXR α ligand-dependent activation function 2 ( AF2 ) is important for mouse development (1998) (36)
Pituitary gonadotroph estrogen receptor-alpha is necessary for fertility in females. (2008) (36)
Purification, functional characterization, and crystallization of the ligand binding domain of the retinoid X receptor. (1995) (36)
A rapid procedure for purification of EcoRI endonuclease. (1977) (36)
The effect of estradiol injections upon chicken liver nuclei ribonucleic acid polymerase. (1963) (36)
Point mutation in the TATA box curtails expression of sea urchin H2A histone gene in vivo (1981) (36)
Retinoids stimulate leptin synthesis and secretion in human syncytiotrophoblast. (2000) (36)
Action mechanism of retinoid-synergistic dibenzodiazepines. (1997) (36)
Heterodimeric complex of RAR and RXR nuclear receptor ligand-binding domains: purification, crystallization, and preliminary X-ray diffraction analysis. (2000) (35)
RadGraph: Extracting Clinical Entities and Relations from Radiology Reports (2021) (35)
Evidence for a factor required for transcriptional stimulation by the chimeric acidic activator GAL-VP16 in HeLa cell extracts. (1991) (35)
Estrogen receptor-α expression in neuronal cells affects bone mass (2012) (35)
History of retinoic acid receptors. (2014) (35)
Estrogen receptor KO mice study on rapid modulation of spines and long-term depression in the hippocampus (2015) (34)
Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes. (2003) (34)
Two Novel RXRα Isoforms from Mouse Testis (1996) (34)
Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone (2012) (34)
Vitamin A deficiency and mutations of RXR α , RXR β and RAR α lead to early differentiation of embryonic ventricular cardiomyocytes (1997) (34)
Inducible site‐specific somatic mutagenesis in mouse hepatocytes (2000) (34)
Sequence of the chicken ovotransferrin gene. (1987) (33)
Estrogen receptor alpha signaling in inflammatory leukocytes is dispensable for 17beta-estradiol-mediated inhibition of experimental autoimmune encephalomyelitis. (2004) (33)
No more than seven interruptions in the ovalbumin gene: comparison of genomic and double-stranded cDNA sequences. (1979) (33)
p21-Activated kinase mediates rapid estradiol-negative feedback actions in the reproductive axis (2009) (33)
Activation of pS 2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7 ( nuclear run-on transcription / cycloheximide / steroid hormone / gene expression / induction ) (32)
Electron microscopy and restriction enzyme mapping reveal additional intervening sequences in the chicken ovalbumin split gene (1978) (32)
The chicken ovalbumin promoter is under negative control which is relieved by steroid hormones. (1987) (32)
A conditional floxed (loxP‐flanked) allele for the retinoic acid receptor beta (RARβ) gene (2002) (32)
Limited specificity and large overlap of the functions of the mouse RARγ1 and RARγ2 isoforms (1997) (32)
The immunoglobulin heavy chain enhancer is stimulated by the adenovirus type 2 E1A products in mouse fibroblasts. (1986) (32)
Expression of human estrogen receptor mutants in Xenopus oocytes: correlation between transcriptional activity and ability to form protein‐DNA complexes. (1988) (32)
Absence of Intestinal PPARγ Aggravates Acute Infectious Colitis in Mice through a Lipocalin-2–Dependent Pathway (2014) (32)
Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1α (2008) (31)
Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse. (2000) (31)
Expression of T : G mismatch-specific thymidine-DNA glycosylase and DNA methyl transferase genes during development and tumorigenesis (1998) (30)
Ligand dependence of estrogen receptor induced changes in chromatin structure. (1992) (30)
Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms. (2005) (30)
Steroid mediated lysis of lymphoblasts requires the DNA binding region of the steroid hormone receptor. (1990) (30)
A close association between sites of DNase I hypersensitivity and sites of enhanced cleavage by micrococcal nuclease in the 5′‐flanking region of the actively transcribed ovalbumin gene. (1984) (29)
Expression of conditional cre recombinase in epithelial tissues of transgenic mice (2003) (29)
Effects of loss of classical estrogen response element signaling on bone in male mice. (2007) (29)
Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue‐specific manner (2013) (29)
Amanitin binding to calf thymus RNA polymerase B (1970) (29)
Expression and function of the human estrogen receptor in yeast. (1988) (29)
The role of activation functions 1 and 2 of estrogen receptor‐α for the effects of estradiol and selective estrogen receptor modulators in male mice (2013) (28)
The role of estrogen receptor α and β in regulating vascular smooth muscle cell proliferation is based on sex. (2012) (28)
pS2 and response to adjuvant hormone therapy in primary breast cancer. (1994) (28)
Contents Vol. 54, 2000 (2001) (28)
Corrected splicing of a chicken ovalbumin gene transcript in mouse L cells. (1980) (28)
How I became one of the fathers of a superfamily (2004) (28)
Transcription of polyoma virus DNA in vitro. Localization of Escherichia coli RNA polymerase initiation sites. (1976) (28)
The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis (2014) (27)
In vivo functional analysis of the mouse estrogen receptor gene promoter: a transgenic mouse model to study tissue-specific and developmental regulation of estrogen receptor gene transcription. (1995) (27)
Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF‐2 deficient mice (2007) (27)
Disruption of TGF-β signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm. (2014) (27)
Specific expression of the retinoic acid-synthesizing enzyme RALDH2 during mouse inner ear development (2001) (27)
Mutation of isoleucine 747 by a threonine alters the ligand responsiveness of the human glucocorticoid receptor. (1996) (27)
TIF1β association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis. (2011) (27)
Control of transcription of the chicken progesterone receptor gene. In vitro and in vivo studies. (1991) (27)
Involvement of Estrogen Receptor &bgr; in the Induction of Polyovular Follicles in Mouse Ovaries Exposed Neonatally to Diethylstilbestrol (2009) (26)
Specific in vitro initiation of transcription on the adenovirus type 2 early and late EII transcription units. (1981) (26)
Structural and functional properties of three mammalian nuclear DNA-dependent RNA polymerases. (1972) (26)
Isolation of retinoic acid-repressed genes from P19 embryonal carcinoma cells. (1996) (26)
Skeletal Consequences of Deletion of Steroid Receptor Coactivator-2/Transcription Intermediary Factor-2* (2009) (26)
Retinoids enhance glucocorticoid-induced apoptosis of T cells by facilitating glucocorticoid receptor-mediated transcription (2011) (26)
Mesectoderm is a major target of retinoic acid action. (1998) (25)
Temporally Controlled Site-Specific Mutagenesis in the Germ Cell Lineage of the Mouse Testis1 (2003) (25)
Retinoid signaling competence and RARβ‐mediated gene regulation in the developing mammalian telencephalon (2005) (25)
Absence of thyroid hormone receptor β–retinoid X receptor interactions in auditory function and in the pituitary–thyroid axis (1998) (25)
Studies on the mechanism of transcription of nucleosomal complexes. (1980) (25)
Retinoic acid receptor-alpha regulates pulmonary alveolus formation in mice after, but not during, perinatal period. (2003) (25)
Hormonally induced alterations of chromatin structure in the polyadenylation and transcription termination regions of the chicken ovalbumin gene. (1986) (25)
The sequence motifs that are involved in SV40 enhancer function also control SV40 late promoter activity. (1987) (25)
Biologic activities of retinoic acid and 3,4-didehydroretinoic acid in human keratinocytes are similar and correlate with receptor affinities and transactivation properties. (1994) (25)
Lung Development and Regeneration (2004) (24)
Estrogen dependent activation function of ERβ is essential for the sexual behavior of mouse females (2012) (24)
Inducible Cre/loxP Recombination in the Mouse Proximal Tubule (2007) (24)
Functional role of RXRs and PPARgamma in mature adipocytes. (2005) (24)
Animal DNA-dependent RNA polymerases. Purification and molecular structure of hen-oviduct and liver class-B RNA polymerases. (1976) (24)
Vaccinia recombinants expressing early bovine papilloma virus (BPV1) proteins: retardation of BPV1 tumour development. (1990) (24)
SRC‐1 Is Necessary for Skeletal Responses to Sex Hormones in Both Males and Females (2004) (24)
Retinal Dystrophy Resulting from Ablation of RXRα in the Mouse Retinal Pigment Epithelium (2004) (24)
Estrogen response element-independent estrogen receptor (ER)-alpha signaling does not rescue sexual behavior but restores normal testosterone secretion in male ERalpha knockout mice. (2007) (24)
SERMs have substance-specific effects on bone, and these effects are mediated via ERαAF-1 in female mice (2016) (24)
Expression of Sox9 in granulosa cells lacking the estrogen receptors, ERalpha and ERbeta. (2003) (23)
A cell-specific factor represses stimulation of transcription in vitro by transcriptional enhancer factor 1 (1994) (23)
TIF I α: chromatin-specific mediator for the ligand-dependent activation function AF-2 of nuclear receptors? (1997) (23)
TRIM involvement in transcriptional regulation. (2012) (23)
Viral enhancer activity in teratocarcinoma cells. (1985) (22)
Repression of the alpha-fetoprotein gene promoter by progesterone and chimeric receptors in the presence of hormones and antihormones (1990) (22)
Abnormal spermatogenesis in RXR [ mutant mice (2007) (22)
The retinoic acid receptors RARalpha and RARgamma are required for inner ear development. (2002) (22)
RAR beta isoforms: distinct transcriptional control by retinoic acid and specific spatial patterns of promoter activity during mouse embryonic development. (1994) (22)
7 – Animal Nuclear DNA-Dependent RNA Polymerases (1974) (22)
Retinoid X receptor gamma-deficient mice have increased skeletal muscle lipoprotein lipase activity and less weight gain when fed a high-fat diet. (2004) (22)
RXRalpha overexpression in cardiomyocytes causes dilated cardiomyopathy but fails to rescue myocardial hypoplasia in RXRalpha-null fetuses. (2000) (22)
Knockdown of parathyroid hormone related protein in smooth muscle cells alters renal hemodynamics but not blood pressure. (2013) (22)
Interdigital apoptosis and downregulation of BAG-1 expression in mouse autopods (2002) (21)
Effect of estradiol on rat uterus DNA-dependent RNA polymerases. Studies on solubilized enzymes. (1976) (21)
Identification of estradiol/ERα-regulated genes in the mouse pituitary. (2011) (21)
Nucleosome structure I: all four histones, H2A, H2B, H3, and H4, are required to form a nucleosome, but an H3-H4 subnucleosomal particle is formed with H3-H4 alone. (1978) (21)
Vaccinia recombinants expressing secreted and transmembrane forms of breast cancer-associated epithelial tumour antigen (ETA). (1991) (21)
Spatio‐temporal distribution of cellular retinoid binding protein gene transcripts in the developing and the adult cochlea. Morphological and functional consequences in CRABP‐ and CRBPI‐null mutant mice (2000) (21)
Multiple initiation and polyadenylation sites for the chicken ovomucoid transcription unit. (1982) (20)
From in vivo gene targeting of oestrogen receptors to optimization of their modulation in menopause (2012) (20)
Subunit SA3 is not mandatory for the activity of calf thymus DNA‐dependent RNA polymerase AI (1975) (20)
Mutation of Arginine 264 on ERα (Estrogen Receptor Alpha) Selectively Abrogates the Rapid Signaling of Estradiol in the Endothelium Without Altering Fertility (2020) (19)
Inhibition of RNA polymerase by sodium polyethylene sulphonate. (1967) (19)
The ovalbumin gene: an amazing gene in eight pieces (1978) (19)
Conditional (loxP‐flanked) allele for the gene encoding the retinoic acid‐synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2) (2006) (19)
F9 embryonal carcinoma cells engineered for tamoxifen-dependent Cre-mediated site-directed mutagenesis and doxycycline-inducible gene expression. (2000) (19)
Specific expression of the pS 2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB 2 (2003) (19)
Targeted Disruption of Retinoic Acid Receptor a (RARa) and RARg Results in Receptor-Specific Alterations in Retinoic Acid-Mediated Differentiation and Retinoic Acid Metabolism (1995) (19)
Disruption of TGF-β signaling in smooth muscle cell prevents flow-induced vascular remodeling. (2014) (19)
Characterization of a retinoic acid responsive element isolated by whole genome PCR. (1992) (19)
Aberrant growth plate development in VDR/RXR gamma double null mutant mice. (2001) (19)
The chicken conalbumin gene: studies of the organization of cloned DNAs. (1979) (18)
Biochemical studies of bacterial sporulation and germination. IX. Ribonucleic acid and deoxyribonucleic acid polymerases in nuclear fractions of vegetative cells and spores of Bacillus megaterium. (1968) (18)
Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms. (1997) (18)
Differential contributions of AF1 and AF2 activities to the developmental functions of RXR α (2001) (18)
Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha/retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivo. (1999) (18)
Inflammatory Mediator TAK1 Regulates Hair Follicle Morphogenesis and Anagen Induction Shown by Using Keratinocyte-Specific TAK1-Deficient Mice (2010) (18)
Estrogen receptor α, but not β, is required for optimal dendritic cell differentiation and of CD40-induced cytokine production (2008) (17)
Transgenic Mice for a Tamoxifen-Induced, Conditional Expression of the Cre Recombinase in Osteoclasts (2012) (17)
Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium. (2003) (17)
The initiation accuracy of the SV40 early transcription is determined by the functional domains of two TATA elements. (1992) (17)
Binding of (3H)-5,5 diphenylhydantoin to rat brain membranes (1981) (17)
Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice (2016) (16)
A rapid and efficient method for region‐ and strand‐specific mutagenesis of cloned DNA. (1982) (16)
ADA3-containing complexes associate with estrogen receptor alpha. (2002) (16)
Adenovirus DNA template for late transcription is not a replicative intermediate (1979) (16)
Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis. (2016) (16)
A trans-acting factor represses the activity of the polyoma virus enhancer in undifferentiated embryonal carcinoma cells. (1987) (16)
Purification of the Human RARγ Ligand-Binding Domain and Crystallization of Its Complex with All-transRetinoic Acid (1997) (15)
TIF1 alpha: a chromatin-specific mediator for the ligand-dependent activation function AF-2 of nuclear receptors? (1997) (15)
Size of the RNA's synthesized by purified Calf thymus DNA‐dependent RNA polymerases on SV40 DNA (1973) (15)
CRYSTAL STRUCTURE OF THE HUMAN RXR ALPHA LIGAND BINDING DOMAIN BOUND TO 9-CIS RETINOIC ACID (2000) (15)
Aggravated TSLP-induced atopic dermatitis in mice lacking Dicer in adult skin keratinocytes. (2011) (15)
Similarities and differences in the transcriptional control of expression of the mouse TSLP gene in skin epidermis and intestinal epithelium (2017) (15)
γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor. (2018) (15)
Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue (2008) (15)
Sex effect in mouse and human prion disease. (2010) (14)
The role of estrogen receptor-αlpha and its activation function 1 (af-1) for growth plate closure in female mice (2012) (14)
Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases. (2007) (14)
Effect of growth hormone administration on soluble DNA-dependent RNA polymerase from rat liver. (1965) (14)
Roles of Hox genes: what we have learnt from gain of function and loss of function mutations in the mouse. (1993) (14)
Class II (B) general transcription factor (TFIIB) that binds to the template-committed preinitiation complex is different from general transcription factor BTF3. (1992) (14)
Two novel RXR alpha isoforms from mouse testis. (1996) (14)
Stimulation of in vitro transcription from heterologous promoters by (1984) (14)
Chimeric receptors used to probe the DNA-binding domain of the estrogen and glucocorticoid receptors. (1989) (14)
Comparative expression of the SPARC and stromelysin-3 genes in mammary tumours (1996) (13)
Keratinocyte-specific retinoid regulation of human cellular retinoic acid binding protein-II (hCRABPII) gene promoter requires an evolutionarily conserved DR1 retinoic acid-responsive element. (1998) (13)
The same amount of DNA is organized in in vitro-assembled nucleosomes irrespective of the origin of the histones. (1978) (13)
Involvement of gonadotropins in the induction of hypertrophy-hyperplasia in the interstitial tissues of ovaries in neonatally diethylstilbestrol-treated mice. (2012) (13)
Epidermal gammadelta T cells sense precancerous cellular dysregulation and initiate immune responses. (2010) (12)
Retinoids and mouse placentation (1998) (12)
Alteration of Hox gene expression in the branchial region of the head causes homeotic transformations, hindbrain segmentation defects and atavistic changes (1995) (12)
Sequence-specific activation of transcription by adenovirus EIa products is observed in HeLa cells but not in 293 cells (1986) (12)
Retinal dysplasia and degeneration in RAR b 2/RAR g 2 compound mutant mice (1996) (12)
Assignment of the human progesterone receptor to the q22 band of chromosome 11 (2004) (12)
Potentiator effect of the SV40 72-bp repeat on initiation of transcription from heterologous promoter elements. (1983) (11)
[Primary structure of human protein pS2]. (1988) (11)
Working memory deficits in retinoid X receptor (cid:1) -deficient mice (2005) (11)
The glucocorticoid receptor agonistic modulators CpdX and CpdX-D3 do not generate the debilitating effects of synthetic glucocorticoids (2019) (11)
Erratum: A canonical structure for the ligand-binding domain of nuclear receptors (1996) (11)
Theca-Specific Estrogen Receptor-Knockout Mice Lose Fertility Prematurely (2009) (11)
A simple and efficient method for the separation and detection of small DNA fragments by electrophoresis in formamide containing agarose gels and Southern blotting to DBM-paper. (1982) (11)
Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis. (2016) (11)
The conserved amphipatic alpha-helical core motif of RARgamma and RARalpha activating domains is indispensable for RA-induced differentiation of F9 cells. (2000) (11)
Looking at nuclear receptors from the heights of Erice (2002) (11)
Soluble DNA dependent RNA polymerase from prostate nuclei. (1965) (11)
Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest loss of rhombomeres 4 (1993) (10)
Estrogen receptor alpha-induced cholecystokinin type A receptor expression in the female mouse pituitary. (2007) (10)
STRUCTURAL ORGANIZATION AND EXPRESSION OF OVALBUMIN AND RELATED CHICKEN GENES (1979) (10)
[Genetic dissection of retinoic acid function in epidermis physiology]. (2002) (10)
[Genetic control of the development by retinoic acid]. (1997) (9)
Purification of mRNA guanylyltransferase from calf thymus. (1982) (9)
Correlation of the exon/intron organization to the conserved domains of the mouse transcriptional corepressor TIF1beta. (2000) (9)
Correction of complex heteroduplexes made of mouse H-2 gene sequences in Escherichia coli K-12. (1984) (9)
Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality (2019) (9)
Protective Hematopoietic Effect of Estrogens in a Mouse Model of Thrombosis: Respective Roles of Nuclear Versus Membrane Estrogen Receptor α. (2015) (8)
Both Retinoic Acid Receptors α (RARα) and γ (RARγ) Are Able to Initiate Mouse Upper-Lip Skin Glandular Metaplasia (1998) (8)
The coactivator TIF 2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and-independent pathways (2013) (8)
Retinoic Acid Nuclear Receptors (1991) (8)
Glucocorticoid receptor modulators CpdX and CpdX-D3 exhibit the same in vivo antiinflammatory activities as synthetic glucocorticoids (2019) (8)
The SV40 Early Promoter (1987) (8)
Control of transcription and neurological diseases (1999) (8)
Characterization of RNA synthesized at high ionic strength by rat liver aggregate RNA polymerase. (1969) (8)
Neonatal Estrogen Receptor β Is Important in the Permanent Inhibition of Epithelial Cell Proliferation in the Mouse Uterus. (2015) (8)
The mouse immunoglobulin heavy-chain gene enhancer contains sequences that inhibit transcription in vitro in HeLa cell extracts (1986) (8)
Failure of x-ray irradiation to inhibit ribonucleic acid polymerase activity in regenerating rat liver nuclei. (1962) (8)
Organization and chromosomal localization of the gene (TAF2H) encoding the human TBP-associated factor II 30 (TAFII30). (1995) (7)
Retinoic Acid Receptor -y : Specific Immunodetection and Phosphorylation (2002) (7)
Roles of activating functions 1 and 2 of estrogen receptor α in lymphopoiesis. (2017) (7)
The ovalbumin split gene: molecular cloning of Eco RI fragments "c" and "d". (1978) (7)
Reexpression of retinoic acid receptor (RAR)y or overexpression of RARa or RARI8 in RARy-null F9 cells reveals a partial functional redundancy between the three RAR types (2005) (6)
O IV.4 Poly(ADP-ribose) polymerase interacts with the base excision repair factor XRCC1 and is required in recovery from DNA damage in mice and in cells (1997) (6)
The retinoic acid receptors alpha and beta are expressed in the human promyelocytic leukemia cell line HL-60. (1989) (6)
Structural and functional studies on mammalian nuclear DNA-dependent RNA polymerases. (1973) (6)
The segmented paper method: DNA synthesis and mutagenesis by rapid microscale "shotgun gene synthesis". (1987) (6)
[Fusion proteins between PML and alpha-RAR in acute promyelocytic leukemia]. (1991) (6)
Direct activation and anti-repression functions of GAL4-VP16 use distinct molecular mechanisms. (1995) (6)
A PstI RFLP for the human retinoic acid receptor in 17q21 (1988) (6)
A New Approach to the Mechanism of Mutations (1959) (5)
Retinal pigment epithelium protein of 65 kDA gene-linked retinal degeneration is not modulated by chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C/ chondroitin sulfate proteoglycan 5 (2013) (5)
Specific in vitro transcription of conalbumin gene is drastically decreased by single-point mutation in TATA box homology sequence ( promoter / eukaryote / surrogate genetics / synthetic oligodeoxyribonucleotide / fd phage ) (5)
Recombinant polyoma--vaccinia viruses: T antigen expression vectors and anti-tumor immunization agents. (1988) (5)
Targeted somatic mutagenesis in mouse epidermis. (2000) (5)
Transcription in vitro of adenovirus-2 DNA by RNA polymerases class C purified from uninfected and adenovirus-infected HeLa cells. (1978) (5)
Title Involvement of Estrogen Receptor Β in the Induction of Polyovular Follicles in Mouse Ovaries Exposed Neonatally to Diethylstilbestrol (5)
Retinoic acid receptors at 35 years. (2022) (5)
Both retinoic acid receptors alpha (RARalpha) and gamma (RARgamma) are able to initiate mouse upper-lip skin glandular metaplasia. (1998) (5)
The conserved amphipatic α-helical core motif of RAR γ and RAR α activating domains is indispensable for RA-induced differentiation of F 9 cells (5)
Transcription fromtheSV40early-early andlate-early overlapping promoters intheabsence ofDNA replication (1983) (5)
p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells (2014) (5)
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis (2021) (5)
Interaction of eukaryotic class-B transcription factors and chick progesterone-receptor complex with conalbumin promoter sequences. (1983) (4)
Identification and Characterization of Retinoic Acid Receptor B 2 Target Genes in F 9 Teratocarcinoma Cells (2003) (4)
Response to Letter from Mucida et al. (2009) (4)
Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production (2021) (4)
96. Abnormal expression of retinoic acid receptors and keratin 19 by human oral and epidermal squamous cell carcinoma cell lines (1992) (4)
Stereospecific relationships between elements in an SV40/adenovirus-2 heterologous promoter. (1989) (4)
Transcription of double-stranded viral and cellular DNAs by purified mammalian DNA-dependent RNA polymerases. (1974) (4)
ADENOVIRUS-2 MAJOR LATE PROMOTER : SEQUENCES UPSTREAM FROM THE TATA BOX ARE ESSENTIAL FOR EFFICIENT IN VIVO AND IN VITRO TRANSCRIPTION (1982) (4)
Nucleosome structure. (1978) (3)
Animal Models for Retinoid Receptor Research: Implications for Epidermal Homeostasis, Skin Barrier Function, Wound Healing, and Atopic Dermatitis (2007) (3)
Revie w F 9 embryocarcinoma cells : a cell autonomous model to study the functional selectivity of RARs and RXRs in retinoid signaling (3)
Transcription regulation in eukaryotes (1999) (3)
Determination of the organization of coding and intervening sequences in the chicken ovalbumin split gene. (1979) (3)
PPAR b / d affects pancreatic b cell mass and insulin secretion in mice (2018) (3)
SUN-744 Phosphorylation Site S122 in Estrogen Receptor α Has a Tissue-Dependent Role in Female Mice (2020) (3)
Structural evidence for two alpha-amanitin sensitive RNA polymerases in calf thymus. (1971) (3)
Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium (2012) (3)
Role of RXRβ in platelet function and arterial thrombosis (2019) (3)
STRUCTURE AND EXPRESSION OF OVALBUMIN AND CLOSELY RELATED CHICKEN GENES (1979) (3)
Estrogen receptor ! is required for optimal dendritic cell development (2008) (2)
BIOSYNTHESIS OF THE RNA AND HOMOPOLYNUCLEOTIDES IN THE CELL NUCLEI OF THE BRAIN (1966) (2)
Exploration of metabolic and endocrine function in the mouse (2006) (2)
Functional role ofRXRs and PPAR g in mature adipocytes (2005) (2)
Summary Cell differentiation induces TIF 1 β association with centromeric heterochromatin via an HP 1 interaction (2)
Genome evolution in prokaryotes and eukaryotes. (1985) (2)
Disruption of TGF-b signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm (2014) (2)
[Free nucleotides in red blood cells and reticulocytes]. (1962) (2)
Developmental expression of the retinoic acid receptor genes, as revealed by in situ hybridization (1989) (2)
Double-Stranded Viral and Cellular DNA's as Templates for Purified Mammalian DNA-Dependent RNA Polymerases (1973) (2)
Hox Gene Function and the Development of the Head (1995) (2)
A novel eukaryotic promoter element: the simian virus 40 72 base pair repeat. (1984) (2)
Some effects of X-rays on the in vivo biosynthesis of nucleic acids capable of explaining the reduction of enzymatic activities and the occurrence of mutations. (1960) (2)
[In vivo study of the effect of x-rays on the free nucleotides of the spleen]. (1959) (2)
Estradiol Alters Nitric Oxide Production in the Mouse Aorta Through the &agr;-, but not &bgr;-, Estrogen Receptor (2002) (2)
Smooth muscle cell specific deletion of the PKGIα target RGS2 induces vascular dysfunction and hypertension (2011) (2)
increased angiogenesis Stromal ER-alpha promotes tumor growth by normalizing an Updated (2012) (2)
Generation of Spatio-Temporally Controlled Targeted Somatic Mutations in the Mouse. (2011) (2)
Differential involvement of insulin-like growth factor-I and estrogen on prolactin cells in the mouse anterior pituitary (2010) (1)
Spatio-temporally-controlled somatic mutations in the mouse. (1998) (1)
[The age of genetics]. (1994) (1)
Differences in Gene Expression between Wild Type and Hoxa1 Knockout Embryonic Stem Cells after Retinoic Acid Treatment or LIF Removal* (2005) (1)
[Specific expression of human pS2 gene in breast cancer]. (1988) (1)
Functional Domains of Steroid Hormone Receptors (1989) (1)
Cre-mediated conditional gene targeting to understand liver functions (2004) (1)
Cloning ofthechicken progesterone receptor (1986) (1)
The role of activation functions 1 and 2 of estrogen receptor‐α for the effects of estradiol and selective estrogen receptor modulators in male mice (2013) (1)
Epidermal gd T cells sense precancerous cellular dysregulation and initiate immune responses (2010) (1)
Title : The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt 5 a signalling in vascular smooth muscle cells (1)
Seeing is believing (2004) (1)
Individual products of the adenovirus 12 S and 13 S EIa mRNAs stimulate viral (1)
ESTROGEN RECEPTOR ALPHA AMPLIFIES THE OSTEOGENIC RESPONSE TO MECHANICAL LOADING IN A LIGAND-INDEPENDENT MANNER BY ITS ACTIVATION FUNCTION 1 BUT NOT 2 (2012) (1)
Vitamin A deﬁciency and mutations of RXR a , RXR b and RAR a lead to early differentiation of embryonic ventricular cardiomyocytes (1997) (1)
Distinct alteration in the biological effects of topical retinoic acid and precursors in mice with disrupted genes for cellular retinoic acid binding proteins (CRABP1 and 2) (1994) (1)
The HP1α protein is mandatory to repress the circadian clock and its output genes during the 12 h period of transcriptional repression (2023) (1)
A comparison of the expression domains of the murine HOX-4, RARs and CRABP genes suggests possible functional relationships during patterning of the vertebrate limb (1991) (1)
A case of human pregnancy after microinjection of capacitated sperm into the perivitelline space (1991) (1)
Multiple isoforms ofthemouse retinoic acidreceptor oc aregenerated byalternative splicing anddifferential induction byretinoic acid (1991) (1)
Immunological and functional quantitation of nuclear retinoid X (RXR) and retinoic acid (RAR) receptor proteins in human epidermis in vivo: High levels of RXRS and RAR-γ, low levels of RAR-α, and absence of RAR-β (1993) (1)
Subject Index Vol. 54, 2000 (2001) (1)
[DNA and RNA polymerase]. (1968) (1)
Edinburgh Research Explorer SERMs have substance specific effects on bone and these effects are mediated via ERAF-1 in female mice (2018) (0)
Phosphorylation of S122 in ER[alpha] is important for the skeletal response to estrogen treatment (2016) (0)
ThesameamountofDNAisorganized ininvitro-assembled nucleosomes irrespective ofthe origin ofthehistones (1978) (0)
Alterations in the Balance of Cardiomyocyte Glucocorticoid and Mineralocorticoid Receptor Signaling Lead to Heart Failure (2017) (0)
Towards a breast cancer vaccine (1989) (0)
Nuclear Receptors as Transcriptional Enhancers (1989) (0)
Abstract 216: Genetic Deletion of Cardiomyocyte Mineralocorticoid Receptors Prevents Cardiac Dysfunction and Premature Death in Mice Lacking Glucocorticoid Receptors in the Heart (2015) (0)
Regulation of intermediate progenitor cells in developing cerebral cortex by Retinoic acid receptor alpha signaling (2011) (0)
Inducible prostate luminal epithelial cell-specific deletion of E-cadherin (CDH1) induces prostatic inflammation, proliferation and bladder overactivity – Characterization of a potential animal model for benign prostatic hyperplasia (2019) (0)
The SV40 72 Base Pair Repeat: An Amazing Enhancer of Eukaryotic Gene Expression (1983) (0)
Modular patterning of structure and function of the striatum in the forebrain by retinoid receptor signaling (2008) (0)
[Free nucleotides in the erythrocytes in rats after x-irradiation]. (1960) (0)
Sex steroids hormone mediate osteoprotecitve effects by controlling osteoclast life cycle (2008) (0)
A Rapid Protocol For Site-directed Mutagenesis and Gene Synthesis Using Synthetic Oligonucleotides (1985) (0)
A process for the production of a protein by yeast using an inducible system, vectors and corresponding transformed strains. (1989) (0)
P30 EUROPEAN COMPREHENSIVE FIRST-LINE PHENOTYPING PROTOCOL FOR MICE: CROSS-LABORATORY VALIDATION OF A PRIMARY BEHAVIOURAL SCREEN TEST BATTERY (2004) (0)
lopmental expression of mouse strom (0)
Stromal ER-alpha promotes tumor growth by normalizing an increased angiogenesis (2012) (0)
EVOLUTION OF ENZYMIC DNA-SYNTHESIZING ACTIVITY IN SOME ORGANS OF THE RAT FOLLOWING X IRRADIATION (1961) (0)
A transgenic mouse, useful in screening for medicaments for the treatment of e.g., diabetes or skin cancers, comprises a fusion protein between a recombinase Cre, and a modified ligand binding domain of the nuclear estrogen receptor alpha (2000) (0)
Method of preparing a protein by yeast using an inducible system, vectors and corresponding strains transformed (1988) (0)
Nuclear glucocorticoid receptor alters, DNA fragments coding for said receiver and processes in which they are implemented (1996) (0)
Differentially expressed isoforms ofthemouse retinoic acidreceptoraregenerated byusage oftwo promoters andalternative splicing (1991) (0)
Sequence of the chkken ovotransferrin gene (1987) (0)
Retinoic acid (RA), a hormonal signal derived from vitamin A (retinol), is essential in vertebrates for controlling processes involved in embryonic patterning and organogenesis, cell proliferation, differentiation and apoptosis, and homeostasis (2001) (0)
[Free nucleotides of erythrocytes after x-ray irradiation]. (1961) (0)
Theimmunoglobulin heavychain enhancer isstimulated bythe adenovirus type2ElAproducts inmousefibroblasts (1986) (0)
[Development of desoxyribonucleic acid-synthetizing enzymatic activities in some organs of the rat after irradiation by xrays]. (1961) (0)
Thetranscriptional activation function located inthe hormone-binding domainofthehumanoestrogen receptor isnotencoded ina single exon (1989) (0)
Attenuation of colon infiammation through the RXR/PPARγ heterodimer: A basis for new therapeutic strategies (2001) (0)
Regulation of the Chicken Ovalbumin Gene Expression by Steroid Hormones in a Transient Assay (1986) (0)
Mice transgenic for targeted recombination mediated by the cre-modified st (2000) (0)
[The free nucleotides in rat splenic tissue]. (1959) (0)
[Distribution of acid-soluble erythrocyte nucleotides in rat]. (1958) (0)
RESULTS Lowering the response of both Hoxa 1 and Hoxb 1 to endogenous retinoids results in malformations of the facial nerve (1998) (0)
0053: The estrogen receptor alpha C451 palmitoylation site is absolutely required for vascular membrane-initiated action of estrogens in mice (2014) (0)
Molecular and Cellular Pathobiology Stromal Estrogen Receptor-a Promotes Tumor Growth by Normalizing an Increased Angiogenesis (2012) (0)
Erratum: Transcription coactivator PBP, the peroxisome proliferator- activated receptor (PPAR)-binding protein, is required for PPARα-regulated gene expression in liver (Journal of Biological Chemistry (2004) 279 (24427-24434)) (2004) (0)
Genetic dissection of retinoid signalling pathways (2004) (0)
62 Keratinocytic Thymic Stromal Lymphopoietin Plays an Important Role in Epicutaneous Sensitization and the Atopic March (2012) (0)
Results shown are the mean ^ s.d. We analysed data by one-way analysis of variance (ANOVA). Individual statistical differences were determined by Scheffe's multiple range comparison test. (2003) (0)
Estrogen controls energy homeostasis via a G protein-coupled signaling pathway in hypothalamic neurons (2006) (0)
(E6) Involvement of RAR-α in the RA inducible regulation of myeloid cell differentiation (1991) (0)
RXRβ NULL MUTATION LEADS TO DEFECTS IN SERTOLI CELL LIPID METABOLISM, AND ABNORMAL SPERMATOGENESIS (1996) (0)
IN VITRO TRANSCRIPTION OF THE ADENOVIRUS TYPE 2 GENOME (1978) (0)
SNF2 b -BRG1 Is Essential for the Viability of F9 Murine Embryonal Carcinoma Cells (1997) (0)
NUCLEAR RECEPTORS (2006) (0)
O29 ALTERED MITOCHONDRIA IN LIVER-SPECIFIC PROHIBITIN-2 NULL MICE INDUCES HEPATIC DAMAGES ASSOCIATED WITH STEATOSIS AND IMPAIRED GLUCONEOGENESIS (2014) (0)
Recent Studies on Animal Ribonucleic Acid Polymerases (1973) (0)
Ligand-dependent activation of ti acid receptor a/retinoid X recept transactivation by retinoids in vii (chromatin template/RXR subordination/synergistic transactiva (2016) (0)
Delayed reduction of the protein level in the striatum after genetic ablation of the tyrosine hydroxylase gene in the substantia nigra (2007) (0)
Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications (2011) (0)
Mandarin Translations (2012) (0)
A007 The transactivating function-1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of estradiol (2009) (0)
The circadian demethylation of a unique intronic deoxymethylCpG-rich island boosts the transcription of its cognate circadian clock output gene (2023) (0)
Steroid hormone receptors: Cloning, structure and function (1986) (0)
[Effect of x-rays on the biosynthesis of nucleic acids and problem of the mutations]. (1959) (0)
Deletion of Focal Adhesion Kinase From the Retinal Pigment Epithelium Results in Progressive Retinal Degeneration in Mice (2010) (0)
Stress response after TIF-2 disruption: loss of grip on feedback control or adrenocortical impairment? (2006) (0)
Selectivity and promiscuity of target enhancers for distinct classes of nuclear receptors (1994) (0)
Title: Inducible ablation of NCAM impairs preformed hippocampus- and cortex-dependent fear memories Location: (2007) (0)
Purification of the human RARgamma ligand-binding domain and crystallization of its complex with all-trans retinoic acid. (1997) (0)
Transcriptional enhancer factor (TEF)-1 and transcriptional intermediary factor (TIF) are active in human keratinocytes: Are they involved in keratinocyte-specific transcription? (1992) (0)
Estrogen receptor alpha expression in cartilage is important for the ameliorating effects of estrogen on synovitis, but not joint destruction (2012) (0)
Protein and its representative fragments specific expression of PS2 gene of breast cancers obtained antibody from said protein and / or fragment thereof, their applications to the detection and diagnosis of breast cancer (1987) (0)
Theovalbumin split gene:molecular cloning ofEcoRIfragments "c"and"d". (1978) (0)
Effect of retinoic acid receptor β (RARβ) deficiency on DC in a conditional mouse line (2011) (0)
Estrogen receptor α (ERα) expression in cartilage is important for the ameliorating effects of estrogen on synovitis, but not joint destruction. (2012) (0)
Corrigendum to “Disruption of TGF- signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm” [Biochem. Biophys. Res. Commun. 454 (1) (7 November 2014) 137–143] (2015) (0)
F1000 recommendations - Cell Metabolism 2011 (2013) (0)
Phenotyping of Host-Pathogen Interactions in Mice (2006) (0)
Nuclear receptors and development (1990) (0)
Use of site-directed mutagenesis to study the structure-function relationship of the human oestrogen receptor (1988) (0)
All-Tram and 94s Retinoic Add Enduction of CRAB(DII Trmriptian Is byRAR-F?XR tbbrodlmrs l3omd to IN?1 and (1992) (0)
Mutation of palmitoylation site of Estrogen Receptor ER alpha in vivo reveals tissue-specific roles for membrane versus genomic effects of estrogens (2014) (0)
P 30 EUROPEANCOMPREHENSIVEFIRST-LINE PHENOTYPINGPROTOCOLFORMICE : CROSS-LABORATORY VALIDATIONOFAPRIMARYBEHAVIOURALSCREENTEST BATTERY (2004) (0)
Synergistic Activation of Retinoic Acid (RA)-Responsive Genes and Induction of Embryonal Carcinoma Cell Differentiation by an RA Receptor (cid:97) (RAR (cid:97) )-, RAR (cid:98) -, or RAR (cid:103) -Selective Ligand in Combination with a Retinoid X Receptor-Speciﬁc Ligand (1995) (0)
Retinoic Acid Signaling Affects (2005) (0)
[The acid-soluble nucleotides in human erythrocytes]. (1959) (0)
Expression patterns of the breast cancer associated pS2 protein in human gastrointestinal tumors (1991) (0)
Dissection of Nuclear Receptor Signalling Pathways through Somatic Spatio-temporally-controlled Targeted Mutagenesis (2003) (0)
Expression of retinoic acid receptors (RAR-α,-β,-γ) and retinoid-X receptors (RXR-α,-β,-γ) in normal and psoriatic skin (1994) (0)
Immunohistological detection of retinoid-X receptor (RXR-α,-β,-γ) expression in normal and psoriatic human skin (1993) (0)
MP06-04 INDUCIBLE PROSTATE LUMINAL EPITHELIAL CELL-SPECIFIC DELETION OF CDH1 INDUCES MURINE PROSTATIC HYPERPLASIA, INFLAMMATION, AND STROMAL FIBROSIS (2019) (0)
Abstract P200: Endothelial Estrogen Receptor Alpha Does Not Protect Female Mice Against Western Diet Induced Vascular Stiffness (2015) (0)
プロモータの前後関係-及び応答要素-依存性転写活性の特異性及びレチノイン酸レセプターの調節機能 (1992) (0)
Negative Control of Viral and Cellular Enhancer Activity by the Products of the Immortalizing E1A Gene of Human Adenovirus-2 (1985) (0)
RARα and TFIIH — direct contact activation (1997) (0)
A process for preparing a protein from yeast using an inducible system, as well as vectors and transformed strains for use in the method (1989) (0)
Activation Function-1 of Estrogen Receptor Cells through Differential Requirement for Inflammatory and Steady-State Dendritic Estradiol Promotes Functional Responses in (2013) (0)
Steroids, Retinoids, and their Mode of Action (1992) (0)
Craniofacial development depends on the enzymatic oxidation of the vitamin A nutrient by the retinaldehyde dehydrogenase type 3 (2004) (0)
A Rapid Method for Simultaneous Chemical Synthesis of Oligonucleotides in Large Nufiber (1985) (0)
Functional Analysis of the Estrogen and Progesterone Receptors (1988) (0)
[Positive control of transcription in eukaryotes]. (1971) (0)
Transcription factor-2 between TIF2 (1997) (0)
Constitutive and inducible transcriptional enhancers (1988) (0)
Summary Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis (0)
Nuclear steam raising plant (1974) (0)
Stromelysin-3 - a paradigm of extracellular proteinase expressed in stromal cells of human carcinomas. (1995) (0)
RAR-. 84 , a retinoic acid receptor isoform is generated from RAR-f 82 by alternative splicing and usage of a CUG initiator codon ( retinoic acid-inducible / non-AUG initiator codon / speiflc expression / development ) (0)
The conalbumin "TATA" box sequence and the SV40 72 base-pair repeat region influence expression of a chimeric gene in vivo. (1982) (0)
Pituitary Gonadotroph Estrogen Receptor- (cid:1) Is Necessary for Fertility in Females (2007) (0)
RXRy null mice are apparently normal and compound RXRa+-/RXR,B-'-/RXRy-'- mutant mice are viable (retinoid (2005) (0)
Analytical markers of cancer, in particular malignant breast cancer (1991) (0)
Facteur-2 intermediaire de la transcription (1997) (0)
The Oestrogen-Induced pS2 Gene and the Oestrogen Receptor in Breast Cancer (1988) (0)
Gene expression pattern Specific expression of the retinoic acid-synthesizing enzyme RALDH2 during mouse inner ear development (2001) (0)
FUNCTIONAL ANALYSIS OF THE ESTROGEN AND (1988) (0)
The Endocrine Society 2011 Laureate Awards. (2011) (0)
Expression of pancreatic spasmolytic polypeptide gene (hSP) correlates with correct transcription of the pS2 gene in human pancreatic carcinoma (1991) (0)
Estrogen regulates physiological bone turnover by targeting mesenchymal cells in mice (2012) (0)
Subject Index to Volume 15 (2001) (0)
Abstract 18218: Vascular Dysfunction as a Primary Cause of Hypertension in Mice with Smooth Muscle Specific Deletion of RGS2 (2011) (0)
Table of Contents (1988) (0)
Correlated activity of the pS2 gene and its domain-duplicated homolog (hSP) in human stomach carcinoma (1991) (0)
Conditional Knockouts: Cre-Lox Systems (2006) (0)
DEVELOPMENT OF DNA-SYNTHESIZING ENZYMATIC ACTIVITIES IN SOME ORGANS OF THE RAT AFTER X IRRADIATION (1961) (0)
Lung Development and Regeneration: Lung Biology in Health and Disease, Vol. 190. (2005) (0)
Contents continued (2001) (0)
Short Communication Hedgehog Signaling Regulates Sebaceous Gland Development (2003) (0)
[Activities of soluble and "aggregated" nuclear RNA-polymerases after partial hepatectomy]. (1965) (0)
Summary Epithelial Bmpr 1 a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development (2004) (0)
[The distribution of free nucleotides in the reticulocytes of the rat]. (1960) (0)
Contents continued (2022) (0)

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