Gunther Hartmann | Academic Influence

Gunther Hartmann's AcademicInfluence.com Rankings

Gunther Hartmann

Medical

#927

World Rank

#1192

Historical Rank

Pharmacology

#120

World Rank

#153

Historical Rank

medical Degrees

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Medical

Gunther Hartmann's Degrees

PhD Pharmacology University of Bonn
Doctorate Medicine University of Bonn

Why Is Gunther Hartmann Influential?

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According to Wikipedia, Gunther Hartmann is a German immunologist and clinical pharmacologist. Since 2007 he has been the Director of the Institute of Clinical Chemistry and Clinical Pharmacology at the University Hospital of the University of Bonn.

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Gunther Hartmann's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing (2007) (3657)
5'-Triphosphate RNA Is the Ligand for RIG-I (2006) (2362)
Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides1 (2002) (2080)
Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7 (2005) (1238)
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate (2009) (866)
Identification of CpG oligonucleotide sequences with high induction of IFN‐α/β in plasmacytoid dendritic cells (2001) (862)
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence (2009) (859)
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. (2009) (734)
Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase (2013) (706)
CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells. (1999) (695)
Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells1 (2000) (647)
Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. (2001) (630)
Delineation of a CpG Phosphorothioate Oligodeoxynucleotide for Activating Primate Immune Responses In Vitro and In Vivo1 (2000) (627)
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates (2014) (452)
Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases. (2002) (448)
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production (2010) (441)
Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. (2001) (426)
Toll‐like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL‐12 (2001) (416)
Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA (2013) (402)
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. (2009) (393)
Activation with CpG-A and CpG-B Oligonucleotides Reveals Two Distinct Regulatory Pathways of Type I IFN Synthesis in Human Plasmacytoid Dendritic Cells 1 (2003) (376)
Discriminating self from non-self in nucleic acid sensing (2016) (358)
5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma (2008) (355)
Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer. (2003) (343)
TRADD protein is an essential component of the RIG-like helicase antiviral pathway. (2008) (336)
Plasmacytoid Dendritic Cells Control TLR7 Sensitivity of Naive B Cells via Type I IFN1 (2005) (332)
Rational design of new CpG oligonucleotides that combine B cell activation with high IFN‐α induction in plasmacytoid dendritic cells (2003) (320)
Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help. (2004) (314)
Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. (2013) (311)
SiRNA delivery with exosome nanoparticles (2011) (289)
Taming TNF: strategies to restrain this proinflammatory cytokine. (1997) (287)
Preferential expression and function of Toll-like receptor 3 in human astrocytes (2004) (270)
Infection fatality rate of SARS-CoV-2 infection in a German community with a super-spreading event (2020) (263)
Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome (2010) (261)
Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-γ and TNF-α production (2001) (246)
Inhibition of Toll-Like Receptor 7- and 9-Mediated Alpha/Beta Interferon Production in Human Plasmacytoid Dendritic Cells by Respiratory Syncytial Virus and Measles Virus (2005) (246)
siRNA and isRNA: two edges of one sword. (2006) (230)
Replication-Dependent Potent IFN-α Induction in Human Plasmacytoid Dendritic Cells by a Single-Stranded RNA Virus1 (2004) (230)
Antisense therapy in oncology: new hope for an old idea? (2001) (228)
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production (vol 11, pg 63, 2010) (2014) (226)
CpG DNA and LPS induce distinct patterns of activation in human monocytes (1999) (219)
Peritumoral CpG DNA Elicits a Coordinated Response of CD8 T Cells and Innate Effectors to Cure Established Tumors in a Murine Colon Carcinoma Model1 (2002) (214)
Exosomes as nucleic acid nanocarriers. (2013) (209)
Plasmacytoid dendritic cells: the key to CpG. (2002) (203)
Enhanced Dendritic Cell Maturation by TNF-α or Cytidine-Phosphate-Guanosine DNA Drives T Cell Activation In Vitro and Therapeutic Anti-Tumor Immune Responses In Vivo1 (2000) (203)
A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2′O-Methylated Self RNA (2015) (199)
Spontaneous Formation of Nucleic Acid-based Nanoparticles Is Responsible for High Interferon-α Induction by CpG-A in Plasmacytoid Dendritic Cells* (2005) (185)
Structural and functional insights into pattern recognition by the innate immune receptor RIG-I (2010) (184)
Role of adenosine receptors in regulating chemotaxis and cytokine production of plasmacytoid dendritic cells. (2004) (181)
Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA (2015) (180)
Specific type IV phosphodiesterase inhibitor rolipram mitigates experimental colitis in mice. (1998) (172)
IL-12p70-Dependent Th1 Induction by Human B Cells Requires Combined Activation with CD40 Ligand and CpG DNA 1 (2004) (171)
Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN (2005) (168)
Nucleic Acid Immunity (2016) (156)
Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany (2020) (155)
CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens (2001) (152)
Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production. (2001) (151)
RIG‐I detects infection with live Listeria by sensing secreted bacterial nucleic acids (2012) (150)
Adenosine kinase inhibitor GP515 improves experimental colitis in mice. (2000) (144)
Type I interferon-mediated autoinflammation due to DNase II deficiency (2017) (144)
B-Cell Lymphomas Differ in their Responsiveness to CpG Oligodeoxynucleotides (2005) (141)
An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice. (2016) (135)
Mechanism of action of CpG DNA. (2000) (133)
Therapeutic efficacy of bifunctional siRNA combining TGF-β1 silencing with RIG-I activation in pancreatic cancer. (2013) (130)
Combined dendritic cell‐ and CpG oligonucleotide‐based immune therapy cures large murine tumors that resist chemotherapy (2002) (130)
T Cell-Independent, TLR-Induced IL-12p70 Production in Primary Human Monocytes1 (2006) (125)
Delivery by Cationic Gelatin Nanoparticles Strongly Increases the Immunostimulatory Effects of CpG Oligonucleotides (2008) (124)
Staphylococcus aureus Protein A Triggers T Cell-Independent B Cell Proliferation by Sensitizing B Cells for TLR2 Ligands1 (2007) (116)
Activation of Endothelial Toll-Like Receptor 3 Impairs Endothelial Function (2011) (112)
CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro. (2004) (112)
Human Plasmacytoid Dendritic Cells Support Th17 Cell Effector Function in Response to TLR7 Ligation (2009) (107)
Selection of Molecular Structure and Delivery of RNA Oligonucleotides to Activate TLR7 versus TLR8 and to Induce High Amounts of IL-12p70 in Primary Human Monocytes1 (2009) (107)
Accessing the therapeutic potential of immunostimulatory nucleic acids. (2008) (105)
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING (2018) (100)
Mechanisms and therapeutic applications of immune stimulatory cpG DNA. (1999) (95)
Turning tumors into vaccines: co-opting the innate immune system. (2013) (92)
Oligodeoxynucleotides Enhance Lipopolysaccharide-Stimulated Synthesis of Tumor Necrosis Factor: Dependence on Phosphorothioate Modification and Reversal by Heparin (1996) (92)
Distinct CpG oligonucleotide sequences activate human γ δ T cells via interferon‐α/‐β (2001) (91)
RNA recognition via TLR7 and TLR8. (2008) (88)
Tumour‐derived prostaglandin E2 and transforming growth factor‐β synergize to inhibit plasmacytoid dendritic cell‐derived interferon‐α (2009) (87)
The Chase for the RIG-I Ligand-Recent Advances. (2010) (87)
CpG-A Oligonucleotides Induce a Monocyte-Derived Dendritic Cell-Like Phenotype That Preferentially Activates CD8 T Cells1 (2003) (84)
ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA (2015) (84)
Approaching the RNA ligand for RIG‐I? (2009) (82)
Free-Circulating Methylated DNA in Blood for Diagnosis, Staging, Prognosis, and Monitoring of Head and Neck Squamous Cell Carcinoma Patients: An Observational Prospective Cohort Study. (2017) (82)
Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells. (2010) (81)
CpG ODN enhance antigen‐specific NKT cell activation via plasmacytoid dendritic cells (2005) (79)
Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8. (2009) (75)
Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids (2020) (74)
Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression (2017) (72)
RIG-I Detects Triphosphorylated RNA of Listeria monocytogenes during Infection in Non-Immune Cells (2013) (72)
Spontaneous and cationic lipid-mediated uptake of antisense oligonucleotides in human monocytes and lymphocytes. (1998) (70)
Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA (2014) (70)
5' Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice. (2011) (70)
Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity. (2010) (68)
Modulation of malignant B cell activation and apoptosis by bcl‐2 antisense ODN and immunostimulatory CpG ODN (2002) (68)
Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response. (2007) (68)
Cytosolic RIG-I–like helicases act as negative regulators of sterile inflammation in the CNS (2011) (68)
Self‐priming determines high type I IFN production by plasmacytoid dendritic cells (2014) (65)
Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes (2014) (64)
Perhalogenierte 1,2,3,5‐Dithiadiazolium‐Salze und 1,2,3,5‐Dithiadiazole (1985) (62)
Inflammasome-Dependent Induction of Adaptive NK Cell Memory. (2016) (61)
Targeting the Cytosolic Innate Immune Receptors RIG‐I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma (2013) (61)
Correlation between a quantitative anti‐SARS‐CoV‐2 IgG ELISA and neutralization activity (2021) (60)
Immunostimulatory RNA Blocks Suppression by Regulatory T Cells (2009) (60)
CpG oligonucleotides: novel regulators of osteoclast differentiation (2002) (60)
Analysis of Plasmacytoid and Myeloid Dendritic Cells in Nasal Epithelium (2006) (60)
In vivo synthesis of tumor necrosis factor-alpha in healthy humans after live yellow fever vaccination. (1998) (60)
Complete regression of advanced primary and metastatic mouse melanomas following combination chemoimmunotherapy. (2009) (59)
Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2. (2020) (58)
Sorafenib in combination with carboplatin and paclitaxel as neoadjuvant chemotherapy in patients with advanced ovarian cancer (2010) (55)
Recent advances in immunostimulatory CpG oligonucleotides. (2003) (55)
Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients (2017) (54)
Dendritic cell vaccination in human melanoma: relationships between clinical effects and vaccine parameters (2010) (51)
Immunotherapy with dendritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancer (2006) (48)
Adrenaline enhances LPS-induced IL-10 synthesis: evidence for protein kinase A-mediated pathway. (1998) (47)
Immunostimulatory properties of CpG-oligonucleotides are enhanced by the use of protamine nanoparticles. (2006) (46)
Structural studies of oligonucleotides containing G-quadruplex motifs using AFM. (2004) (44)
Specific suppression of human tumor necrosis factor-alpha synthesis by antisense oligodeoxynucleotides. (1996) (44)
Immunostimulatory RNA Oligonucleotides Induce an Effective Antitumoral NK Cell Response through the TLR71 (2009) (43)
Suppression of tumor necrosis factor-alpha production by interleukin-10 is enhanced by cAMP-elevating agents. (1997) (41)
Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells (2011) (41)
Toll-like receptors (TLRs) and innate immunity (2008) (40)
RIG-I activation induces the release of extracellular vesicles with antitumor activity (2016) (40)
A Human In Vitro Whole Blood Assay to Predict the Systemic Cytokine Response to Therapeutic Oligonucleotides Including siRNA (2013) (38)
Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4+ T cell help (2021) (35)
Cutting Edge: The RIG-I Ligand 3pRNA Potently Improves CTL Cross-Priming and Facilitates Antiviral Vaccination (2016) (35)
Beyond Double-Stranded RNA-Type I IFN Induction by 3pRNA and Other Viral Nucleic Acids (2007) (35)
Distinct CpG oligonucleotide sequences activate human gamma delta T cells via interferon-alpha/-beta. (2001) (34)
Identification of Materials Parameters for Inelastic Constitutive Models Using Principles of Biologic Evolution (1989) (34)
Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self‐DNA based on CpG‐specific recognition of phosphodiester DNA (2009) (34)
Stressing hematopoiesis and immunity: an acetylcholinesterase window into nervous and immune system interactions (2012) (32)
Shock waves: a novel method for cytoplasmic delivery of antisense oligonucleotides (2001) (31)
AChE and RACK1 Promote the Anti-Inflammatory Properties of Fluoxetine (2014) (31)
Improved sensitivity for detection of breast cancer by combination of miR-34a and tumor markers CA 15-3 or CEA (2018) (31)
Synthese und Struktur von [CpFe(CO)2SO2]+ AsF6- / Synthesis and Structure of [CpFe(CO)2SO2]+ AsF6– (1982) (30)
Anti-inflammatory properties of unfractioned heparin in patients with highly active ulcerative colitis: a pilot study. (1997) (30)
CpG oligonucleotides induce strong humoral but only weak CD4+ T cell responses to protein antigens in rhesus macaques in vivo. (2005) (30)
Clinical Performance of CEA, CA19-9, CA15-3, CA125 and AFP in Gastrointestinal Cancer Using LOCI™-based Assays. (2017) (29)
Influence of Acute Exposure to High Altitude on Basal and Postprandial Plasma Levels of Gastroenteropancreatic Peptides (2012) (29)
High RIG‐I expression in ovarian cancer associates with an immune‐escape signature and poor clinical outcome (2019) (29)
Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy. (2020) (28)
Efficient solid-phase synthesis of pppRNA by using product-specific labeling. (2014) (27)
Endothelial RIG-I activation impairs endothelial function. (2012) (26)
Specific expression of k63-linked ubiquitination of calmodulin-like protein 5 in breast cancer of premenopausal patients (2013) (26)
Activation of Dendritic Cells and Induction of T Cell Responses by Hpv 16 L1/E7 Chimeric Virus-Like Particles are Enhanced by Cpg ODN or Sorbitol (2004) (25)
RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation (2017) (25)
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 (2022) (24)
Monocyte-Mediated Inhibition of TLR9-Dependent IFN-α Induction in Plasmacytoid Dendritic Cells Questions Bacterial DNA as the Active Ingredient of Bacterial Lysates (2010) (24)
Where Failure Is Not an Option –Personalized Medicine in Astronauts (2015) (24)
TLR8-driven IL-12–dependent Reciprocal and Synergistic Activation of NK Cells and Monocytes by Immunostimulatory RNA (2009) (23)
Human TLR8 Senses RNA From Plasmodium falciparum-Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells (2019) (23)
CpG oligonucleotides elicit antitumor responses in a human melanoma NOD/SCID xenotransplantation model. (2004) (23)
RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection. (2017) (23)
A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N 1 -2 0 O-Methylated (2015) (22)
A mass spectrometric investigation of the lower thermosphere above Fort Churchill with special emphasis on the helium content (1969) (22)
Clinical performance of LOCI™-based tumor marker assays for tumor markers CA 15-3, CA 125, CEA, CA 19-9 and AFP in gynecological cancers (2017) (20)
Suppression of TNF‐α production in human mononuclear cells by an adenosine kinase inhibitor (2000) (19)
No Indication for a Defect in Toll-Like Receptor Signaling in Patients with Hyper-IgE Syndrome (2005) (19)
Crystal structures of thionitrosyl hexafluoroantimonate(V) and thionitrosyl undecafluorodiantimonate(V) at 293 K and of thionitrosyl undecafluorodiantimonate(V) at 121.5 K: the effect of thermal motion on the apparent NS bond length (1981) (19)
Deficiency in coatomer complex I causes aberrant activation of STING signalling (2022) (19)
Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells. (2009) (18)
MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I (2021) (18)
Direct RIG‐I activation in human NK cells induces TRAIL‐dependent cytotoxicity toward autologous melanoma cells (2019) (18)
Suppression of TNF-alpha production in human mononuclear cells by an adenosine kinase inhibitor. (2000) (17)
Diagnostic Performance of a Novel Multiplex Immunoassay in Colorectal Cancer. (2017) (16)
Manual of Antisense Methodology (2012) (16)
MDA‐5 activation by cytoplasmic double‐stranded RNA impairs endothelial function and aggravates atherosclerosis (2016) (16)
A computational comparison of the inelastic constitutive models of hart and miller (1987) (16)
Spectroscopic studies of trans-bis(hexafluroarsenato)tetrakis(thiazyl trifluoride)metal(II) complexes (M = Mn, Fe, Co, Ni, or Cu); crystal structure of the manganese(II) complex: an example of exceptionally short N–S bonds and of AsF6– as a unidentate ligand (1981) (14)
Absence of cGAS-mediated type I IFN responses in HIV-1–infected T cells (2020) (14)
Cytokines and therapeutic oligonucleotides. (1997) (13)
Animal models of SARS-CoV-2 and COVID-19 for the development of prophylactic and therapeutic interventions (2021) (13)
Plasmacytoid Dendritic Cells : A New Cutaneous Dendritic Cell Subset with Distinct Role in In £ ammatory Skin Diseases (2002) (12)
Analysis of integrated clinical trial protocols in early phases of medicinal product development (2017) (12)
Individualized versus standardized risk assessment in patients at high risk for adverse drug reactions (IDrug) – study protocol for a pragmatic randomized controlled trial (2016) (12)
Analysis of Serum miRNA in Glioblastoma Patients: CD44-Based Enrichment of Extracellular Vesicles Enhances Specificity for the Prognostic Signature (2020) (12)
VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation (2012) (12)
Comparison of the uniaxial behavior of the inelastic constitutive models of Miller and Walker by numerical experiments (1990) (12)
Yeast Virus-Derived Stimulator of the Innate Immune System Augments the Efficacy of Virus Vector-Based Immunotherapy (2014) (12)
Nucleic acid adjuvants: toward an educated vaccine. (2012) (12)
Thionylimide–transition metal complexes (1983) (12)
RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection (2021) (11)
Thiazyl-[bis(trifluoromethyl)nitroxide] and tris- { thiazyl-[bis(trifluoromethyl) nitroxide] } (1986) (11)
Delivery with Polycations Extends the Immunostimulant Ribomunyl® into a Potent Antiviral Toll-Like Receptor 7/8 Agonist (2011) (11)
Identification of specific nuclear structural protein alterations in human breast cancer (2011) (11)
Potentials and Limitations of Ultrasonic Clamp Load Testing (2007) (10)
Bestimmung von Lanthan, Cer und Neodym mit energiedispersiver Röntgenfluorescenzanalyse (1986) (10)
Enzymatic synthesis and purification of a defined RIG-I ligand. (2014) (10)
Pentacarbonylrhenium Complexes with Thiazylamide Ligands (1983) (9)
Mitf silencing cooperates with IL-12 gene transfer to inhibit melanoma in mice. (2010) (9)
Kristallstruktur von Hexakis (thiazylfluorid) nickel (II)-hexafluoroarsenat / Crystal Structure of Hexakis(thiazylfluoride)nickel(II) Hexafluoroarsenate (1980) (8)
Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA (2016) (8)
Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration (2021) (8)
Synthesis and Structure of the 7-Trifluoromethyl-1,3,5,2,4,6,8-trithiatetrazocine Cation†‡ (1984) (8)
The hairy cell leukemia cell line Eskol spontaneously synthesizes tumor necrosis factor-α and nitric oxide (1998) (8)
Cationic Thionitrosyl and Nitrosyl Complexes (1985) (8)
The PNPLA3 I148M variant promotes lipid-induced hepatocyte secretion of CXC chemokines establishing a tumorigenic milieu (2019) (7)
Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction (2020) (7)
Diagnostic relevance of a novel multiplex immunoassay panel in breast cancer (2017) (7)
Evaluating the immune responses stimulated by CpG oligodeoxynucleotides. (2003) (7)
The coffee ingredients caffeic acid and caffeic acid phenylethyl ester protect against irinotecan‐induced leukopenia and oxidative stress response (2020) (7)
Targeted Nanoparticle Delivery of Bifunctional RIG-I Agonists to Pancreatic Cancer. (2019) (7)
Extracellular Vesicle Separation Techniques Impact Results from Human Blood Samples: Considerations for Diagnostic Applications (2021) (7)
1.3-Dichlor-5-trifluormethyl-1,3-dithia-2,4,6-triazin / 1.3-Dichloro-5-trifluoromethyl-1,3-dithia-2,4,6-triazine (1984) (7)
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy (2021) (7)
Abstract B44: Selective stimulation of RIG-I with a novel synthetic RNA induces strong anti-tumor immunity in mouse tumor models (2017) (7)
Autoradiographische Untersuchungen über das Wachstum des Reissnerschen Fadens von Cyprinus carpio (L.) (2004) (7)
Immune- and miRNA-response to recombinant interferon beta-1a: a biomarker evaluation study to guide the development of novel type I interferon- based therapies (2015) (6)
Sodium and Sodium Alloys (2000) (6)
Hydroxyindole; 4‐Keto‐4,5,6,7‐tetrahydro‐indole aus Cyclohexandion‐1,3 und Isonitrosocarbonyl‐Verbindungen (2010) (6)
Gene silencing below the immune radar. (2009) (6)
ADA2 is a lysosomal DNase regulating the type-I interferon response (2020) (6)
Calponin-h2: a potential serum marker for the early detection of human breast cancer? (2014) (6)
RIG-I dependent sensing of poly ( dAdT ) via the induction of an RNA polymerase III transcribed RNA intermediate (2014) (6)
SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA (2022) (6)
Zur quantitativen Auswertung von Autoradiogrammen mit elektronischen Hilfsmitteln (1973) (6)
Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus (2021) (6)
Identification and Functional Analysis of Tumor-Infiltrating Plasmacytoid Dendritic Cells in Head and Neck Cancer 1 (2003) (5)
Zur Auswirkung des Latentbild-Fadings bei der quantitativen Autoradiographie (1968) (5)
Monocyte-dependent co-stimulation of cytokine induction in human γδ T cells by TLR8 RNA ligands (2021) (5)
Spontanruptur der Uterusvene in der Schwangerschaft (1981) (4)
Über die gewünschte hörerlautstärke bei kammermusik (1987) (4)
G-rich DNA-induced stress response blocks type-I-IFN but not CXCL10 secretion in monocytes (2016) (4)
Oligonucleotide uptake in leukocytes is dependent on extracellular calcium: a hint for the involvement of adhesion molecules? (1998) (4)
Structural and functional insights into pattern recognition by the innate immune receptor RIGI (2016) (4)
The hairy cell leukemia cell line Eskol spontaneously synthesizes tumor necrosis factor-alpha and nitric oxide. (1998) (4)
Synthese und Struktur des 7‐Trifluormethyl‐1,3,5,2,4,6,8‐trithiatetrazocin‐Kations (1984) (4)
Phenprocoumon Dose Requirements, Dose Stability and Time in Therapeutic Range in Elderly Patients With CYP2C9 and VKORC1 Polymorphisms (2020) (3)
Oligonucleotides: Extrapolating from in vitro to in vivo (1997) (3)
CpG: unraveling the key to B-cell function (2003) (3)
This information is current as in Human Plasmacytoid Dendritic Cells Regulatory Pathways of Type I IFN Synthesis Oligonucleotides Reveals Two Distinct Activation with CpG-A and CpG-B (2017) (3)
Therapeutic tissue regeneration by a macrophage colony-stimulating factor Fc conjugate. (2014) (3)
The chase for the RIG-I ligand--recent advances. (2010) (3)
Auswertung von autoradiogrammen und von bildern biologischer objekte mit dem elektronischen bildauswertegerät „Densitron II“ (1976) (3)
Human Beta Papillomavirus Type 8 E1 and E2 Proteins Suppress the Activation of the RIG-I-Like Receptor MDA5 (2022) (3)
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner. (2023) (2)
A continuous responder algorithm to optimize clinical management of small-cell lung cancer with progastrin-releasing peptide as a simple blood test (2020) (2)
Diagnostic Potential of Exosomal microRNAs in Colorectal Cancer (2022) (2)
Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T cell and IgG 2 a response Running title : Immunostimulatory RNA oligonucleotides (2006) (2)
Interferon-beta-induced changes in neuroimaging phenotypes of appetitive motivation and reactivity to emotional salience (2019) (2)
Detectable SARS-CoV-2 RNAemia in Critically Ill Patients, but Not in Mild and Asymptomatic Infections (2021) (2)
Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity (2022) (2)
Hydroxyindole; Substituierte 4‐Hydroxyindole durch Dehydrierung von 4‐Keto‐4, 5, 6, 7‐tetrahydro‐indolen (2010) (2)
Comprar Toll-Like Receptors (TLRs) and Innate Immunity | Bauer, Stefan | 9783540721666 | Springer (2008) (1)
A novel serum extracellular vesicle protein signature to monitor glioblastoma tumor progression (2022) (1)
Das Immunsystem der Nukleinsäureerkennung (2016) (1)
SPANNUNGSRISSBILDUNG BEI THERMOPLASTISCHEN KUNSTSTOFFEN (1990) (1)
A message from the Oligonucleotide Therapeutics Society. (2012) (1)
Induction of Interferon-Stimulated Genes Correlates with Reduced Growth of Influenza A Virus in Lungs after RIG-I Agonist Treatment of Ferrets (2022) (1)
Microenvironment and Immunology Therapeutic Ef fi cacy of Bifunctional siRNA Combining TGF-b 1 Silencing with RIGI Activation in Pancreatic Cancer (2013) (1)
Poly(I:C) treatment prevents skin tumor formation in the preclinical HPV8 transgenic mouse model. (2022) (1)
Production in Primary Human Monocytes T Cell-Independent, TLR-Induced IL-12p70 (2014) (1)
Activation with CD 40 Ligand and CpG DNA Human B Cells Requires Combined IL-12 p 70-Dependent Th 1 Induction by Gunther (2003) (1)
Lipide und die Prävention der koronaren Herzkrankheit: Diagnostik und Massnahmen : aktualisierte Empfehlungen (1992) (1)
Über den optimalen nachhall in kleinen bis mittelgrossen kirchen (1982) (1)
Masken südamerikanischer Naturvölker (1967) (1)
RIG-I immunotherapy overcomes radioresistance in p53-positive malignant melanoma (2022) (1)
U-DCS: characterization of the first permanent human dendritic sarcoma cell line (2020) (1)
Xingú : unter Indianern in Zentral-Brasiliens : zur einhundertjährigen Wiederkehr der Erforschung des Rio Xingú durch Karl von den Steinen (1986) (1)
Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing (2022) (1)
Immunohistological analysis of in‐transit metastasis in a patient with advanced melanoma treated with combination therapy of cytosine guanine dinucleotide oligodeoxynucleotide, dacarbazine and beta‐interferon: A case report (2012) (1)
Analytische Probleme bei Untersuchungen von bio-geochemischen Kreisläufen am Beispiel der Spurenelemente Zn und As (1984) (1)
TIDES 2006--IBC conference. Oligonucleotide and peptide technology and product development. 1-3 May 2006, Carlsbad, CA, USA. (2006) (0)
BIOM-24. PROTEIN SURFACE SIGNATURE ON SERUM EXTRACELLULAR VESICLES FOR NON-INVASIVE DETECTION OF TUMOR PROGRESSION IN GLIOBLASTOMA PATIENTS (2021) (0)
RIG-I-vermittelte Protektion gegenüber SARS-CoV-2 Virusreplikation (2021) (0)
Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus (2021) (0)
Applications of CpG oligonucleotides in cancer therapy (2001) (0)
Immune sensing of synthetic, bacterial and protozoan RNA by TLR8 requires coordinated processing of RNA substrates by RNaseT2 and RNase2 (2020) (0)
Isolierung und Aktivierung von humanen dendritischen Zellen mit CpG-Oligonukleotiden (1999) (0)
A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA (2022) (0)
Colon Carcinoma Model to Cure Established Tumors in a Murine Effectors Response of CD8 T Cells and Innate Peritumoral CpG DNA Elicits a Coordinated (2002) (0)
5'-triphosphate-oligonucleotide with blunt end and its uses (2008) (0)
Gold und Silber : Gold der Kuna, Panama, Silberschmuck der Mapuche, Chile (1988) (0)
RNA Interference in Scope of Immune System (2008) (0)
Abstract 16211: Activation of Endothelial Toll Like Receptor 3 Impairs Endothelial Function and Promotes Atherosclerosis (2011) (0)
Karg-Elerts Harmonologik : Vorstufen und Stellungnahmen (2001) (0)
Differential gene expression profile analysis of RIG-I- versus type I IFN-stimulated primary human nasal epithelial cells and protection from influenza virus replication (2019) (0)
CpG ODNs enhance recall and prmary specific human CTL responses (2001) (0)
Stachelkristalle und modulatoren (2014) (0)
Immune- and miRNA-response to recombinant interferon beta-1a: a biomarker evaluation study to guide the development of novel type I interferon- based therapies (2015) (0)
Ein autoradiographisches Verfahren zur Aufnahme von Strömungsfeldern in Grenzsehiehten (1974) (0)
NLRP3-Independent Inflammasome Activation By Proteasome Inhibitors (2022) (0)
12. Wohnbauten der Naturvölker / Domestic architecture of the primitive people (2011) (0)
Adäquates Vorgehen bei Beckenendlagengeburten an Standardabteilungen (2008) (0)
The NLRP3 specific inhibitor CP-456,773 potently attenuates crystal-induced kidney fibrosis in vivo (2016) (0)
Connecting element for two machine parts or particular fitting elongation screw, passport-threaded bolt o. The like. (1999) (0)
Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency (2023) (0)
and Sensitivity to CpG Oligodeoxynucleotides Human Peripheral Blood Mononuclear Cells 10 mRNA in Cellular Subsets of - Receptor 1 Quantitative Expression of Toll-Like (2002) (0)
Releasable connecting element for a component with a Schrabteil and a retaining ring (2002) (0)
Combination of CpG and antibodies to CD19, CD20, CD22 or CD40 in the prevention or treatment of cancer. (2001) (0)
Screw with a head bearing surface lubricant bags (2012) (0)
Feed guide unit for a hand-held machine tool Geradführen (2009) (0)
Innate immune sensing of nucleic acids and application for oligonucleotide-based immunotherapy (2013) (0)
MA11.09 Progastrin-Releasing Peptide (ProGRP) to Rule out Progressive Disease in Patients with Small Cell Lung Carcinoma (SCLC) (2017) (0)
ANTISENSE STRATEGIES FOR INHIBITION OF TUMOR NECROSIS FACTOR-ALPHA SYNTHESIS (1997) (0)
Releasable connection element to a component, comprising a threaded part and the brake ring. (2001) (0)
Releasable connecting element for a vehicle, comprising a screw and a supporting ring (2000) (0)
Releasable connecting member for a component, comprising a screw member and a securing ring (2000) (0)
Separable union element for a wheel of a vehicle with a screw element and a support ring. (2001) (0)
Apoptosis induction in ovarian cancer cells (2008) (0)
AChE and RACK1 Promote the Anti-Inflammatory Properties of Fluoxetine (2013) (0)
by Regulatory T Cells Immunostimulatory RNA Blocks Suppression (2009) (0)
Response to TLR7 Ligation Support Th17 Cell Effector Function in Human Plasmacytoid Dendritic Cells (2009) (0)
Thiazyl(bis(trifluoromethyl)nitroxide) and Tris(thiazyl(bis(trifluoromethyl)nitroxide)). (1987) (0)
T Cells Phenotype That Preferentially Activates CD8 Monocyte-Derived Dendritic Cell-Like CpG-A Oligonucleotides Induce a (2003) (0)
SYNTHESIS AND STRUCTURE OF 7-TRIFLUOROMETHYL-1,3,5,2,4,6,8-TRITHIATETRAZOCINE CATION (1985) (0)
A Simple Method for the Preparation of Cationic Organometallic Sulfur‐Dioxide Complexes by Metal‐Metal Bond Cleavage. (1986) (0)
Nucleic acid receptor ligands improve vaccination efficacy against the filarial nematode Litomosoides sigmodontis (2022) (0)
Bacterial Lysates Bacterial DNA as the Active Ingredient of Plasmacytoid Dendritic Cells Questions Induction in α TLR 9-Dependent IFN-Monocyte-Mediated Inhibition of Schildgen (2010) (0)
Sensitivity of Naive B Cells via Type I IFN Plasmacytoid Dendritic Cells Control TLR7 (2005) (0)
Type I interferon-mediated autoinflammation due to DNase II deficiency (2017) (0)
VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation (2012) (0)
PERHALOGENATED 1,2,3,5-DITHIADIAZOLIUM SALTS AND 1,2,3,5-DITHIADIAZOLES (1985) (0)
THIONYLIMIDE-TRANSITION METAL COMPLEXES (1983) (0)
RIG-I-mediated protection from SARS-CoV-2 virus replication (2021) (0)
Analysis of integrated clinical trial protocols in early phases of medicinal product development (2017) (0)
CATIONIC THIONITROSYL- AND NITROSYL COMPLEXES (1985) (0)
Binding-Pocket and Lid-Regi on Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA Graphical (2014) (0)
Loss of the Immunomodulatory Transcription Factor BATF2 in Humans Is Associated with a Neurological Phenotype (2023) (0)
Pharmakologische Suppression der Synthese von Tumor-Nekrose-Faktor (2000) (0)
How to Characterize and Improve Oligonucleotide Uptake into Leukocytes (1999) (0)
Retinoic Acid–Inducible Gene I Activation Inhibits Human Respiratory Syncytial Virus Replication in Mammalian Cells and in Mouse and Ferret Models of Infection (2022) (0)
Some reactions of metal-hexafluoro-arsenates with silyl amines (1982) (0)
Plasmacytoid dendritic cells in tumor tissue as target for immuno-therapy with CpG oligonucleotides of head and neck squamous cell carcinoma (2001) (0)
SPECTROSCOPIC STUDIES OF TRANS-BIS(HEXAFLUOROARSENATO)TETRAKIS(THIAZYL TRIFLUORIDE)METAL(II) COMPLEXES (M = MN, FE, CO, NI, OR CU); CRYSTAL STRUCTURE OF THE MANGANESE(II) COMPLEX: AN EXAMPLE OF EXCEPTIONALLY SHORT N-S BONDS OF ASF6- A (1981) (0)
Sensitizing B Cells for TLR2 Ligands Cell-Independent B Cell Proliferation by Staphylococcus aureus Protein A Triggers T (2013) (0)
BIOM-40. ANALYSIS OF SERUM MIRNA IN GLIOBLASTOMA PATIENTS: TARGETED ENRICHMENT OF EXTRACELLULAR VESICLES ENHANCES SPECIFICITY FOR PROGNOSTIC SIGNATURE (2020) (0)
Nuclear matrix protein alterations in triple-negative breast cancer (2012) (0)
Response through the TLR7 Induce an Effective Antitumoral NK Cell Immunostimulatory RNA Oligonucleotides (2009) (0)
Effective immunotherapy of large established tumors with CpG oligonucleotides and dendritic cells in murine tumor models (2001) (0)
Kombination von antigenbeladenen dendritischen Zellen, CpG-Oligonukleotiden und Chemotherapie zur Behandlung von Tumoren im murinen Kolonkarzinom-Modell (2015) (0)
Wettbewerbsordnung im Spannungsfeld von Wirtschafts- und Rechtswissenschaft : [Festschrift für Gunther Hartmann] (1976) (0)
Addendum: Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production (2013) (0)
Analyse von Spurenelementen in biologischen Matrices: Ergänzende und vergleichende Untersuchungen mit der energiedispersiven Röntgenfluorescenzanalyse und der Graphitrohrofen-Atomabsorptionsspektrometrie am Beispiel von Fichtennadeln (1985) (0)
Ionizing radiation improves RIG-I mediated immunotherapy through enhanced p53 activation in malignant melanoma (2021) (0)
Zur Farbstoffdispersionsstabilität bei erhöhter Temperatur (1987) (0)
10:15 - 10:30 5'-triphosphate dsRNA-induced stimulation of RIG-I prevents influenza H1N1 infection of primary nasal epithelial cell culture and protects mice from infection in vivo (2011) (0)
B-A-C-H-STRUKTUREN BEI C. PH. E. BACH (1990) (0)
Identifizierung und Charakterisierung tumorinduzierter Immunmechanismen in einem C57Bl/6 syngenen Maus-Ovarialkarzinommodell (2014) (0)
Zur Darstellungsform von Schmuckelementen bei Tonfiguren der Karaja (Brasilien) (1983) (0)
Expression of a Functional Mx1 Protein Is Essential for the Ability of RIG-I Agonist Prophylaxis to Provide Potent and Long-Lasting Protection in a Mouse Model of Influenza A Virus Infection (2022) (0)
Structure and use of oligonucleotides 5 'phosphate (2007) (0)
Zur Darstellungsform der Frauenschurze bei den Tonfiguren der Karaja, Brasilien (1985) (0)
Zeitgemäßer Fischschutz an bestehenden Anlagen — ein Beispiel (2015) (0)
Abschleppöse für ein Kraftfahrzeug (2002) (0)
Zusammensetzungen enthaltend immunstimulierende RNA-Oligonukleotide und Methoden zu deren Herstellung (2005) (0)
Molakana : Volkskunst der Cuna Panama (1980) (0)
Infektionsletalität von SARS-CoV-2: Eine immunologische Fragestellung (2020) (0)
Identifizierung und quantitative Analyse plasmazytoider und myeloider dendritischer Zellen in der Nasenschleimhaut (2004) (0)
Keramik des Alto Xingú, Zentral-Brasilien (1987) (0)
RIG-I activation primes and trains innate antiviral immune memory (2022) (0)
Influence on study outcomes of an inpatient study by the behavior of the study staff (PINgPOng): study protocol for a randomized clinical trial (2022) (0)
Eine immunologische Fragestellung (2020) (0)
Quantitative protein biomarker panels: a path to improved clinical practice through proteomics (2023) (0)
Funktion von extrazellulären Vesikeln und Bedeutung für die labormedizinische Diagnostik (2017) (0)
PROPHYLAXE UND THERAPIE DER HOHENKRANKHEIT (1997) (0)
X-chromosomale TLR7-Expression bei Frauen und Prädisposition zu Lupus-assoziierter Autoimmunität (2021) (0)
Erfassung und Auswertung von Helicobacter Pylori Resistenzen in einer Stichprobe in Vorarlberg (2019) (0)
Logistikorientierte Fabrikstrukturen―Aufgaben und Lösungsansätze für die Projektierung, Steuerung, Instandhaltung und Arbeitsgestaltung (1992) (0)

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