Patrick Sung
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American biochemist and biophysicist
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Physics Biology
Patrick Sung's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is Patrick Sung Influential?
(Suggest an Edit or Addition)According to Wikipedia, Patrick Sung is an American professor of structural biology and biochemistry at the University of Texas Health Science Center at San Antonio. He is known for his work on DNA repair. Biography Sung was born on May 24, 1959, in Hong Kong. In 1981, he got his Bachelor of Science degree from the University of Liverpool and four years later got his Ph.D. from Oxford University. From 1993 to 1997 he was an assistant professor at the University of Texas Medical Branch and from that year till 2001 served as an associate professor of the University of Texas Health Science Center at San Antonio where he also became chairman of its graduate program and even became a professor of its Department of Molecular Medicine. In 2000 Sung became an editor of the Molecular and Cellular Biology and in 2003 was an associate editor of the Genes to Cells journal. The same year he became professor at both Therapeutic Radiology and Molecular Biophysics and Biochemistry departments of Yale University and from that year till 2005 served at the Genes & Developments' editorial board. From 2003 till 2004 he was Special Emphasis Panels' member.
Patrick Sung's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mechanism of eukaryotic homologous recombination. (2008) (1512)
- Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein. (1994) (874)
- Mechanism of homologous recombination: mediators and helicases take on regulatory functions (2006) (653)
- DNA helicase Srs2 disrupts the Rad51 presynaptic filament (2003) (609)
- Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase. (1997) (549)
- Function of Yeast Rad52 Protein as a Mediator between Replication Protein A and the Rad51 Recombinase* (1997) (543)
- Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. (2005) (525)
- DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA (1995) (514)
- Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95* (1998) (444)
- DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis (1999) (442)
- Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins (1998) (431)
- Rad51 Recombinase and Recombination Mediators* (2003) (428)
- Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae (2010) (371)
- Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites. (1994) (317)
- Human xeroderma pigmentosum group D gene encodes a DMA helicase (1993) (314)
- Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes. (2001) (313)
- RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. (2007) (307)
- DNA repair genes and proteins of Saccharomyces cerevisiae. (1993) (290)
- DNA Structure-specific Nuclease Activities in theSaccharomyces cerevisiae Rad50·Mre11 Complex* (2001) (289)
- Radiation-induced Assembly of Rad51 and Rad52 Recombination Complex Requires ATM and c-Abl* (1999) (288)
- Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration (2013) (261)
- The Saccharomyces cerevisiae DNA repair gene RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function (1993) (259)
- Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange. (2001) (252)
- 53BP1, BRCA1, and the Choice between Recombination and End Joining at DNA Double-Strand Breaks (2014) (245)
- Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination. (2009) (243)
- Interactions of the DNA Ligase IV-XRCC4 Complex with DNA Ends and the DNA-dependent Protein Kinase* (2000) (237)
- Reconstitution of Yeast Nucleotide Excision Repair with Purified Rad Proteins, Replication Protein A, and Transcription Factor TFIIH (*) (1995) (235)
- A Double Holliday Junction Dissolvasome Comprising BLM, Topoisomerase IIIα, and BLAP75* (2006) (232)
- The Yeast Hex3·Slx8 Heterodimer Is a Ubiquitin Ligase Stimulated by Substrate Sumoylation* (2007) (222)
- BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing (2017) (222)
- Mutation of lysine‐48 to arginine in the yeast RAD3 protein abolishes its ATPase and DNA helicase activities but not the ability to bind ATP. (1988) (221)
- Superhelicity-driven homologous DNA pairing by yeast recombination factors Rad51 and Rad54. (2000) (221)
- Regulation of Rad51 Function by c-Abl in Response to DNA Damage* (1998) (220)
- Recruitment of the recombinational repair machinery to a DNA double-strand break in yeast. (2003) (216)
- Evidence for Involvement of Yeast Proliferating Cell Nuclear Antigen in DNA Mismatch Repair* (1996) (210)
- Yeast Rad54 Promotes Rad51-dependent Homologous DNA Pairing via ATP Hydrolysis-driven Change in DNA Double Helix Conformation* (1999) (210)
- BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. (2008) (205)
- MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. (2010) (201)
- Recombination factors of Saccharomyces cerevisiae. (2000) (192)
- Functional Interactions among Yeast Rad51 Recombinase, Rad52 Mediator, and Replication Protein A in DNA Strand Exchange* (2000) (189)
- Rad54p Is a Chromatin Remodeling Enzyme Required for Heteroduplex DNA Joint Formation with Chromatin* (2003) (188)
- Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange (2004) (186)
- RAD3 protein of Saccharomyces cerevisiae is a DNA helicase. (1987) (185)
- Yeast Rad51 Recombinase Mediates Polar DNA Strand Exchange in the Absence of ATP Hydrolysis* (1996) (179)
- Basis for Avid Homologous DNA Strand Exchange by Human Rad51 and RPA* (2001) (174)
- DNA Sequence Alignment by Microhomology Sampling during Homologous Recombination (2015) (170)
- Concentration-Dependent Exchange of Replication Protein A on Single-Stranded DNA Revealed by Single-Molecule Imaging (2014) (170)
- Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation (2011) (169)
- The RAD6 protein of Saccharomyces cerevisiae polyubiquitinates histones, and its acidic domain mediates this activity. (1988) (167)
- Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function. (2006) (164)
- Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3 (1996) (156)
- Enhancement of the RAD51 Recombinase Activity by the Tumor Suppressor PALB2 (2010) (155)
- Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation. (2009) (154)
- RAD25 is a DMA helicase required for DNA repair and RNA polymerase II transcription (1994) (150)
- Tailed duplex DNA is the preferred substrate for Rad51 protein‐mediated homologous pairing (2000) (149)
- The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication (2020) (147)
- Mutation of cysteine-88 in the Saccharomyces cerevisiae RAD6 protein abolishes its ubiquitin-conjugating activity and its various biological functions. (1990) (145)
- Homologous DNA Pairing by Human Recombination Factors Rad51 and Rad54* (2002) (145)
- Role of Dnl4–Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination (2007) (144)
- Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome. (2006) (144)
- Differential Contributions of Mammalian Rad54 Paralogs to Recombination, DNA Damage Repair, and Meiosis (2006) (142)
- Promotion of Rad51-dependent D-loop formation by yeast recombination factor Rdh54/Tid1. (2000) (140)
- Yeast Xrs2 Binds DNA and Helps Target Rad50 and Mre11 to DNA Ends* (2003) (134)
- Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death (2019) (134)
- A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination (2010) (134)
- Yeast excision repair gene RAD2 encodes a single-stranded DNA endonuclease (1993) (133)
- Affinity of Yeast Nucleotide Excision Repair Factor 2, Consisting of the Rad4 and Rad23 Proteins, for Ultraviolet Damaged DNA* (1998) (132)
- Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry. (2015) (132)
- Recombination Mediator and Rad51 Targeting Activities of a Human BRCA2 Polypeptide* (2006) (132)
- ATP-dependent Assembly of a Ternary Complex Consisting of a DNA Mismatch and the Yeast MSH2-MSH6 and MLH1-PMS1 Protein Complexes* (1998) (131)
- Base triplet stepping by the Rad51/RecA family of recombinases (2015) (129)
- Regulation of DNA pairing in homologous recombination. (2014) (129)
- DNA repair gene RAD3 of S. cerevisiae is essential for transcription by RNA polymerase II (1994) (126)
- Interaction with Rad51 Is Indispensable for Recombination Mediator Function of Rad52* (2002) (125)
- Structure of the Rad50·Mre11 DNA Repair Complex fromSaccharomyces cerevisiae by Electron Microscopy* (2001) (122)
- Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement. (2007) (120)
- An Affinity of Human Replication Protein A for Ultraviolet-damaged DNA (1996) (111)
- Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase. (2007) (107)
- Biochemical mechanism of DSB end resection and its regulation. (2015) (106)
- Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N‐end‐recognizing E3 enzyme. (1991) (102)
- Purification and characterization of the Saccharomyces cerevisiae RAD1/RAD10 endonuclease. (1993) (101)
- The RAD3 gene of Saccharomyces cerevisiae encodes a DNA-dependent ATPase. (1987) (101)
- Physical and Functional Interaction between the XPF/ERCC1 Endonuclease and hRad52* (2004) (101)
- A comparative analysis of Dmc1 and Rad51 nucleoprotein filaments (2008) (100)
- Yeast Rad7-Rad16 Complex, Specific for the Nucleotide Excision Repair of the Nontranscribed DNA Strand, Is an ATP-dependent DNA Damage Sensor* (1997) (99)
- The Rad50 Coiled Coil Domain is indispensable for Mre11 complex functions (2011) (99)
- Nucleotide Excision Repair in Yeast Is Mediated by Sequential Assembly of Repair Factors and Not by a Pre-assembled Repairosome (*) (1996) (99)
- Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament (2016) (97)
- FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3 (2008) (97)
- Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability (2008) (96)
- Hed1 regulates Rad51-mediated recombination via a novel mechanism. (2008) (94)
- Yeast DNA-repair gene RAD14 encodes a zinc metalloprotein with affinity for ultraviolet-damaged DNA. (1993) (93)
- FANCI Binds Branched DNA and Is Monoubiquitinated by UBE2T-FANCL* (2009) (92)
- Enhancement of MSH2–MSH3-mediated mismatch recognition by the yeast MLH1–PMS1 complex (1997) (91)
- Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells. (2004) (90)
- The extremely conserved amino terminus of RAD6 ubiquitin-conjugating enzyme is essential for amino-end rule-dependent protein degradation. (1993) (87)
- Physical Interaction of RECQ5 Helicase with RAD51 Facilitates Its Anti-recombinase Activity* (2010) (86)
- Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks. (2014) (85)
- Plasticity of the Mre11–Rad50–Xrs2–Sae2 nuclease ensemble in the processing of DNA-bound obstacles (2017) (84)
- NUCLEOSOME DYNAMICS REGULATE DNA PROCESSING (2013) (84)
- Single Strand DNA Binding and Annealing Activities in the Yeast Recombination Factor Rad59* (1999) (82)
- Saccharomyces cerevisiae MPH1 Gene, Required for Homologous Recombination-mediated Mutation Avoidance, Encodes a 3′ to 5′ DNA Helicase* (2005) (81)
- Direct and indirect roles of RECQL4 in modulating base excision repair capacity. (2009) (81)
- Overcoming natural replication barriers: differential helicase requirements (2011) (80)
- RAD26, the Yeast Homolog of Human Cockayne's Syndrome Group B Gene, Encodes a DNA-dependent ATPase* (1996) (79)
- The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination. (2019) (78)
- Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivo (2009) (77)
- Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA (2014) (76)
- Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange (2016) (76)
- Role of ATP Hydrolysis in the Antirecombinase Function of Saccharomyces cerevisiae Srs2 Protein* (2004) (75)
- Functional Role of BLAP75 in BLM-Topoisomerase IIIα-dependent Holliday Junction Processing* (2008) (75)
- Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms (2014) (74)
- Interaction with RPA Is Necessary for Rad52 Repair Center Formation and for Its Mediator Activity* (2008) (74)
- Yeast Recombination Factor Rdh54 Functionally Interacts with the Rad51 Recombinase and Catalyzes Rad51 Removal from DNA* (2006) (74)
- Yeast DNA Repair Protein RAD23 Promotes Complex Formation between Transcription Factor TFIIH and DNA Damage Recognition Factor RAD14 (*) (1995) (74)
- Targeting Cancer with a Lupus Autoantibody (2012) (74)
- The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI. (2011) (71)
- Reconstitution of TFIIH and Requirement of Its DNA Helicase Subunits, Rad3 and Rad25, in the Incision Step of Nucleotide Excision Repair (*) (1996) (71)
- A DNA-translocating Snf2 molecular motor: Saccharomyces cerevisiae Rdh54 displays processive translocation and extrudes DNA loops. (2007) (70)
- Functional Cross-talk among Rad51, Rad54, and Replication Protein A in Heteroduplex DNA Joint Formation* (2002) (70)
- Multiple Interactions with the Rad51 Recombinase Govern the Homologous Recombination Function of Rad54* (2004) (69)
- Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption (2009) (67)
- Rad52 SUMOylation affects the efficiency of the DNA repair (2010) (67)
- Cooperativity of Mus81·Mms4 with Rad54 in the Resolution of Recombination and Replication Intermediates*S⃞ (2009) (67)
- Restriction of replication fork regression activities by a conserved SMC complex. (2014) (66)
- Stress and DNA repair biology of the Fanconi anemia pathway. (2014) (65)
- Functions and regulation of the multitasking FANCM family of DNA motor proteins (2015) (64)
- Processing of DNA structures via DNA unwinding and branch migration by the S. cerevisiae Mph1 protein. (2011) (64)
- Multifaceted role of the Topo IIIα–RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection (2014) (64)
- Protein dynamics during presynaptic complex assembly on individual ssDNA molecules (2014) (64)
- The DNA-dependent ATPase Activity of Yeast Nucleotide Excision Repair Factor 4 and Its Role in DNA Damage Recognition* (1998) (64)
- Mending the break: two DNA double-strand break repair machines in eukaryotes. (2003) (63)
- Specific complex formation between proteins encoded by the yeast DNA repair and recombination genes RAD1 and RAD10. (1992) (62)
- Regulation of Rad51 function by phosphorylation (2011) (62)
- Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52 (2015) (61)
- Differential arrangements of conserved building blocks among homologs of the Rad50/Mre11 DNA repair protein complex. (2004) (60)
- DNA Pairing and Strand Exchange by the Escherichia coli RecA and Yeast Rad51 Proteins without ATP Hydrolysis (2001) (60)
- Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates (2016) (60)
- Dual requirement for the yeast MMS19 gene in DNA repair and RNA polymerase II transcription (1996) (58)
- Molecular Anatomy of the Recombination Mediator Function of Saccharomyces cerevisiae Rad52* (2008) (58)
- Effect of Amino Acid Substitutions in the Rad50 ATP Binding Domain on DNA Double Strand Break Repair in Yeast* (2005) (58)
- Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteins. (2014) (58)
- Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP. (2017) (58)
- Transcription factor TFIIH and DNA endonuclease Rad2 constitute yeast nucleotide excision repair factor 3: implications for nucleotide excision repair and Cockayne syndrome. (1996) (55)
- Tetratricopeptide-motif-mediated interaction of FANCG with recombination proteins XRCC3 and BRCA2. (2006) (55)
- RSC Facilitates Rad59-Dependent Homologous Recombination between Sister Chromatids by Promoting Cohesin Loading at DNA Double-Strand Breaks (2011) (55)
- Investigations of Homologous Recombination Pathways and Their Regulation (2013) (55)
- A conserved 5' to 3' exonuclease activity in the yeast and human nucleotide excision repair proteins RAD2 and XPG. (1994) (54)
- Structure-specific Nuclease Activity in Yeast Nucleotide Excision Repair Protein Rad2 (*) (1995) (54)
- ATPase and DNA Helicase Activities of the Saccharomyces cerevisiae Anti-recombinase Srs2* (2003) (54)
- DNA helicase Srs 2 disrupts the Rad 51 presynaptic filament (2003) (53)
- Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks (2016) (52)
- UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide (2020) (51)
- Stable ester conjugate between the Saccharomyces cerevisiae RAD6 protein and ubiquitin has no biological activity. (1991) (51)
- Regulation of Rad51 Recombinase Presynaptic Filament Assembly via Interactions with the Rad52 Mediator and the Srs2 Anti-recombinase* (2009) (51)
- Down-Regulation of Rad51 Activity during Meiosis in Yeast Prevents Competition with Dmc1 for Repair of Double-Strand Breaks (2014) (51)
- Role of the Rad52 Amino-terminal DNA Binding Activity in DNA Strand Capture in Homologous Recombination* (2009) (50)
- Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination (2020) (50)
- Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex. (2007) (50)
- Mechanistic insights into the role of Hop2–Mnd1 in meiotic homologous DNA pairing (2013) (50)
- Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells (2017) (49)
- Holliday Junction Processing Activity of the BLM-Topo IIIα-BLAP75 Complex* (2007) (48)
- Role of the Pif1-PCNA Complex in Pol δ-Dependent Strand Displacement DNA Synthesis and Break-Induced Replication. (2017) (46)
- Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. (2003) (46)
- Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination (2019) (46)
- NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability (2015) (46)
- DNA double-strand break processing: the beginning of the end. (2008) (45)
- The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers. (2019) (45)
- Holliday junction cleavage by yeast Rad1 protein (1994) (45)
- Human RAD52 interactions with replication protein A and the RAD51 presynaptic complex (2017) (44)
- Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex. (2016) (44)
- Significance of ligand interactions involving Hop2-Mnd1 and the RAD51 and DMC1 recombinases in homologous DNA repair and XX ovarian dysgenesis (2015) (43)
- Purification and assays of Saccharomyces cerevisiae homologous recombination proteins. (2006) (43)
- FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress (2013) (42)
- Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection (2016) (42)
- Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex. (2010) (42)
- Role of Saw1 in Rad1/Rad10 complex assembly at recombination intermediates in budding yeast (2013) (42)
- Multiplicity of DNA end resection machineries in chromosome break repair. (2009) (41)
- Structural transitions within human Rad51 nucleoprotein filaments (2009) (40)
- Synergistic Interaction between Yeast Nucleotide Excision Repair Factors NEF2 and NEF4 in the Binding of Ultraviolet-damaged DNA* (1999) (40)
- C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex. (2019) (40)
- Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability. (2016) (40)
- Multifaceted role of the Saccharomyces cerevisiae Srs2 helicase in homologous recombination regulation. (2005) (39)
- A Variant of the Breast Cancer Type 2 Susceptibility Protein (BRC) Repeat Is Essential for the RECQL5 Helicase to Interact with RAD51 Recombinase for Genome Stabilization* (2012) (39)
- Mechanistic Insights into RAD51-associated Protein 1 (RAD51AP1) Action in Homologous DNA Repair* (2012) (39)
- A novel role for non-ubiquitinated FANCD2 in response to hydroxyurea-induced DNA damage (2016) (39)
- Synthetic viability genomic screening defines Sae2 function in DNA repair (2015) (38)
- A novel role of the Dna2 translocase function in DNA break resection. (2017) (36)
- Interplay between Ku and Replication Protein A in the Restriction of Exo1-mediated DNA Break End Resection* (2015) (36)
- Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1) (2011) (36)
- ATP-dependent Chromatin Remodeling by the Saccharomyces cerevisiae Homologous Recombination Factor Rdh54* (2008) (35)
- Yeast Srs2 Helicase Promotes Redistribution of Single-Stranded DNA-Bound RPA and Rad52 in Homologous Recombination Regulation. (2017) (35)
- Human xeroderma pigmentosum group G gene encodes a DNA endonuclease. (1994) (35)
- DNA.RNA helicase activity of RAD3 protein of Saccharomyces cerevisiae. (1991) (34)
- Renaturation of DNA catalysed by yeast DNA repair and recombination protein RAD1O (1992) (34)
- Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2. (2017) (34)
- Regulatory control of Sgs1 and Dna2 during eukaryotic DNA end resection (2019) (34)
- Negative superhelicity promotes ATP-dependent binding of yeast RAD3 protein to ultraviolet-damaged DNA. (1994) (34)
- DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response (2019) (34)
- Rad5-dependent DNA Repair Functions of the Saccharomyces cerevisiae FANCM Protein Homolog Mph1* (2012) (34)
- Role of Replication Protein A in Double Holliday Junction Dissolution Mediated by the BLM-Topo IIIα-RMI1-RMI2 Protein Complex* (2013) (32)
- Nucleosome-like, Single-stranded DNA (ssDNA)-Histone Octamer Complexes and the Implication for DNA Double Strand Break Repair* (2017) (32)
- Effects of Tumor-associated Mutations on Rad54 Functions* (2004) (32)
- RIF1 in DNA break repair pathway choice. (2013) (31)
- Fanconi anemia protein FANCI functions in ribosome biogenesis (2019) (31)
- Rad51 paralog complex Rad55–Rad57 acts as a molecular chaperone during homologous recombination (2020) (30)
- Rad51 presynaptic filament stabilization function of the mouse Swi5–Sfr1 heterodimeric complex (2012) (30)
- Structural insights into 5′ flap DNA unwinding and incision by the human FAN1 dimer (2014) (29)
- Stimulation of the Human RAD51 Nucleofilament Restricts HIV-1 Integration In Vitro and in Infected Cells (2011) (29)
- Lethality in Yeast of Trichothiodystrophy (TTD) Mutations in the Human Xeroderma Pigmentosum Group D Gene (1995) (29)
- Role of RAD51AP1 in homologous recombination DNA repair and carcinogenesis. (2017) (29)
- Novel Attributes of Hed1 Affect Dynamics and Activity of the Rad51 Presynaptic Filament during Meiotic Recombination* (2011) (28)
- Activation of Protein Kinase Tel1 through Recognition of Protein-Bound DNA Ends (2011) (28)
- Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence (2021) (27)
- The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes (2014) (27)
- Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombination (2019) (26)
- Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodeling. (2007) (26)
- Functional interactions of meiotic recombination factors Rdh54 and Dmc1. (2009) (26)
- Visualizing the disassembly of S. cerevisiae Rad51 nucleoprotein filaments. (2009) (25)
- The budding yeast Mei5-Sae3 complex interacts with Rad51 and preferentially binds a DNA fork structure. (2011) (25)
- Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast. (2019) (25)
- Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA substrates (2019) (25)
- Meiotic Recombination: An Affair of Two Recombinases (2004) (24)
- Meiosis-specific recombinase Dmc1 is a potent inhibitor of the Srs2 antirecombinase (2018) (24)
- Chromosomal integration of LTR-flanked DNA in yeast expressing HIV-1 integrase: down regulation by RAD51 (2006) (23)
- The Fanconi Anemia Proteins FANCD2 and FANCJ Interact and Regulate Each Other's Chromatin Localization* (2014) (23)
- Rad52 SUMOylation affects the efficiency of the DNA repair (2012) (23)
- Regulation of Hed1 and Rad54 binding during maturation of the meiosis‐specific presynaptic complex (2018) (23)
- Functional attributes of the Saccharomyces cerevisiae meiotic recombinase Dmc1. (2013) (22)
- Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance (2018) (21)
- Roles of DNA helicases in the mediation and regulation of homologous recombination. (2013) (20)
- Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection (2018) (19)
- Sequence imperfections and base triplet recognition by the Rad51/RecA family of recombinases (2017) (19)
- MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers (2019) (19)
- Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1 (2016) (19)
- The RecQ helicase Sgs1 drives ATP-dependent disruption of Rad51 filaments (2019) (19)
- Spontaneous self-segregation of Rad51 and Dmc1 DNA recombinases within mixed recombinase filaments (2018) (18)
- Promotion and regulation of homologous recombination by DNA helicases. (2010) (18)
- Introduction to the Thematic Minireview Series: DNA double-strand break repair and pathway choice (2018) (18)
- Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors (2011) (17)
- Rad52, Maestro of Inverse Strand Exchange. (2017) (17)
- Selective modulation of the functions of a conserved DNA motor by a histone fold complex (2015) (17)
- RAD51-associated Protein 1 (RAD51AP1) Interacts with the Meiotic Recombinase DMC1 through a Conserved Motif* (2011) (17)
- A DNA nick at Ku-blocked double-strand break ends serves as an entry site for exonuclease 1 (Exo1) or Sgs1–Dna2 in long-range DNA end resection (2018) (17)
- Assay for human Rad51-mediated DNA displacement loop formation. (2009) (17)
- A Germline Polymorphism of Thymine DNA Glycosylase Induces Genomic Instability and Cellular Transformation (2014) (17)
- Tolerance of DNA Mismatches in Dmc1 Recombinase-mediated DNA Strand Exchange* (2015) (16)
- A novel role for non-ubiquitinated FANCD2 in response to hydroxyurea-induced DNA damage (2017) (16)
- Characterization of the Interaction between the Saccharomyces cerevisiae Rad51 Recombinase and the DNA Translocase Rdh54* (2013) (16)
- The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway (2019) (16)
- The MRX complex regulates Exo1 resection activity by altering DNA end structure (2018) (16)
- Rad52 multimerization is important for its nuclear localization in Saccharomyces cerevisiae. (2008) (16)
- Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions (2020) (16)
- Mediating repair (2005) (14)
- Dynamic interactions of the homologous pairing 2 (Hop2)–meiotic nuclear divisions 1 (Mnd1) protein complex with meiotic presynaptic filaments in budding yeast (2018) (14)
- Solution Structure and DNA-binding Properties of the Winged Helix Domain of the Meiotic Recombination HOP2 Protein* (2014) (13)
- The innate immune DNA sensor cGAS is a negative regulator of DNA repair hence promotes genome instability and cell death (2018) (12)
- The E 3 ubiquitin ligase RAD 18 regulates ubiquitylation and chromatin loading of FANCD 2 and FANCI (2011) (12)
- Avoidance of rNMP-induced mutations via RNaseH2 and Srs2-Exo1 dependent mechanisms (2014) (12)
- Mechanism and significance of chromosome damage repair by homologous recombination. (2020) (12)
- Ddc2ATRIP promotes Mec1ATR activation at RPA-ssDNA tracts (2019) (11)
- Dual and Opposite Effects of hRAD51 Chemical Modulation on HIV-1 Integration. (2015) (10)
- Tumor-intrinsic PD-L1 promotes DNA repair in distinct cancers and suppresses PARP inhibitor-induced synthetic lethality. (2022) (10)
- RPA not that different from SSB. (2002) (9)
- A Tale of Loops and Tails: The Role of Intrinsically Disordered Protein Regions in R-Loop Recognition and Phase Separation (2021) (9)
- Tumor‐associated mutations in O6‐methylguanine DNA‐methyltransferase (MGMT) reduce DNA repair functionality (2014) (9)
- Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates (2020) (9)
- Rad54 and Rdh54 occupy spatially and functionally distinct sites within the Rad51‐ssDNA presynaptic complex (2020) (8)
- Cooperativity of Mus81 (cid:1) Mms4 with Rad54 in the Resolution of Recombination and Replication Intermediates * □ (2020) (8)
- Roles of DNA helicases and Exo1 in the avoidance of mutations induced by Top1-mediated cleavage at ribonucleotides in DNA (2016) (8)
- The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair (2020) (8)
- The Rad 50 Coiled Coil Domain is indispensable for Mre 11 complex functions (2012) (8)
- Determining the RAD51-DNA Nucleoprotein Filament Structure and Function by Cryo-Electron Microscopy. (2018) (7)
- A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity (2021) (7)
- Reconstituted System for the Examination of Repair DNA Synthesis in Homologous Recombination. (2017) (7)
- Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes (2019) (6)
- A comparative analysis of Dmc 1 and Rad 51 nucleoprotein filaments (2019) (6)
- Molecular mechanism of resolving trinucleotide repeat hairpin by helicases. (2015) (6)
- The splicing component ISY1 regulates APE1 in base excision repair. (2019) (5)
- Biochemical studies on human Rad51-mediated homologous recombination. (2011) (5)
- Importance of homo-dimerization of Fanconi-associated nuclease 1 in DNA flap cleavage (2017) (5)
- Binding of FANCI-FANCD 2 Complex to RNA and R-Loops Stimulates Robust FANCD 2 Monoubiquitination (2019) (5)
- INTS11 regulates hematopoiesis by promoting PRC2 function (2021) (5)
- NUCKS 1 is a novel RAD 51 AP 1 paralog important for homologous recombination and genome stability (2015) (4)
- Rad 51-mediated recombination via a novel mechanism (2008) (4)
- Recent Advances in Biochemistry Mechanism of Eukaryotic Homologous Recombination (2008) (4)
- FMRP bridges R-loops and DHX9 through direct interactions (2021) (4)
- Rad54 and Rdh54 prevent Srs2-mediated disruption of Rad51 presynaptic filaments (2022) (4)
- DNA damage and repair in aging (2021) (4)
- Assembly and function of a bacterial genotoxin (3)
- Clearance of roadblocks in replication fork restart (2011) (3)
- filaments suppresses tumor formation via disruption of Rad 51 presynaptic RECQL 5 / Recql 5 helicase regulates homologous recombination and Material Supplemental (2007) (3)
- To Cut or Not to Cut: Discovery of a Novel Regulator of DNA Break Resection. (2016) (3)
- DNA End-Processing and Heteroduplex DNA Formation During Recombinational Repair of DNA Double-Strand Breaks (2001) (3)
- Senataxin: A Putative RNA: DNA Helicase Mutated in ALS4—Emerging Mechanisms of Genome Stability in Motor Neurons (2020) (2)
- FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress (2013) (2)
- Biochemical Analysis of D-Loop Extension and DNA Strand Displacement Synthesis. (2021) (2)
- Corrigendum: UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide. (2021) (2)
- The nuclease activity of DNA2 promotes exonuclease 1–independent mismatch repair (2022) (2)
- RAD51AP1 and RAD54L Can Underpin Two Distinct RAD51-Dependent Routes of DNA Damage Repair via Homologous Recombination (2022) (2)
- ATP-dependent Chromatin Remodeling by the Saccharomyces cerevisiaeHomologous Recombination (2008) (2)
- 900 Depleting non-canonical, cell-intrinsic PD-L1 signals induces synthetic lethality to small molecule DNA damage response inhibitors in an immune independent and dependent manner (2021) (2)
- The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells (2020) (2)
- A DNA translocating Snf2 molecular motor: S. cerevisiae Rdh54 displays processive translocation and can extrude DNA loops (2009) (2)
- Binding of FANCD2 to SRSF1 Splicing Factor Prevents Genomic Instability through R Loop Regulation (2020) (1)
- DNA Binding and Strand Annealing Properties of the Human BRCA2DNA Binding Domain (2005) (1)
- Base Triplet Stepping by the Rad51/RecA Family of Recombinases during Strand Exchange (2016) (1)
- Single-molecule studies of yeast Rad51 paralogs. (2021) (1)
- Regulation of Exo1-mediated DNA end resection (2015) (1)
- The RAD 3 gene of Saccharomyces cerevisiae encodes a DNA-dependent ATPase ( RAD 3 protein / DNA repair / yeast ) (1)
- Rad52 multimerization is important for its nuclear localization in S. cerevisiae (2008) (1)
- Regulation of Rad51 recombinase presynaptic filament assembly via interactions with the Rad52 mediator and the Srs2 anti-recombinase. (2012) (1)
- Long-term survival of an ovarian cancer patient harboring a RAD51C missense mutation (2021) (1)
- Phospho-dependent recruitment of NuA4 by MRX at DNA breaks regulates RPA dynamics during resection (2013) (1)
- Faculty Opinions recommendation of Isomerization of BRCA1-BARD1 promotes replication fork protection. (2019) (0)
- Abstract 2481: RAD51 and AICDA define a new synthetic lethal interaction that is targetable in multiple tumor types (2017) (0)
- Molecular Cell Previews Rad 52 , Maestro of Inverse Strand Exchange (2017) (0)
- A Nuclease DNA complex (2014) (0)
- Structural insights into DNA lesion bypass. (2008) (0)
- Purification and Characterization of the Saccharomyces cereuisiae RADl / RADlO Endonuclease * (2001) (0)
- Structural insights into the DNA recognition and protein interaction domains reveal fundamental homologous DNA pairing properties of HOP2 (2014) (0)
- Yeast DNA-repair gene RAD 14 encodes a zinc metalloprotein with affinity for ultraviolet-damaged DNA ( xeroderma pigmentosum / DNA damage-binding protein / Saccharomyces cerevisiae ) (2005) (0)
- Anand, NAR 2011.full (2015) (0)
- Activation of Protein Kinase Tel1 through Recognition of Protein-Bound DNA Ends (cid:1) (2011) (0)
- Mutation of cysteine88 cysteine88 cysteine88 in the Saccharomyces cerevisiae RAD 6 protein abolishes its ubiquitinconjugating ubiquitinconjugating ubiquitinconjugating activity and its various biological functions ( DNA (0)
- Telomerase promoter-switched HSV thymidine kinase expression affects ganciclovir toxicity in glioblastoma cells and xenografts (2006) (0)
- Abstract 4319: Lupus antibody-based cancer therapy. (2013) (0)
- Role of BRCA2/FANCD1 in Homologous Recombination (2005) (0)
- Human RAD51 presynaptic complex (2016) (0)
- RAD51AP1 and RAD54 underpin two distinct RAD51-dependent routes of DNA damage repair via homologous recombination (2021) (0)
- A nuclease-DNA complex form 3 (2014) (0)
- Abstract 2612: Structural and functional insights into the role of human BCDX2 complex in RAD51-dependent homologous recombination by cryoEM (2023) (0)
- Human RAD51 post-synaptic complexes (2016) (0)
- Of forks and ends. (2002) (0)
- Correction for Fukunaga et al., “Activation of Protein Kinase Tel1 through Recognition of Protein-Bound DNA Ends” (2017) (0)
- Erratum: MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers (Proceedings of the National Academy of Sciences of the United States of America (2019) 116 (17438–17443) DOI: 10.1073/pnas.1903150116) (2020) (0)
- Pif1 peptide bound to PCNA trimer (2018) (0)
- Human MHF1 MHF2 DNA complexes (2014) (0)
- TLK1-mediated RAD54 phosphorylation spatio-temporally regulates Homologous Recombination Repair (2022) (0)
- Repair pathway crosstalk in genome stability maintenance through BRCA1/2‐mediated homologous recombination (352.1) (2014) (0)
- Junction Processing-dependent α BLM-Topoisomerase III Functional Role of BLAP 75 in and Chromosome Dynamics : DNA : Replication , Repair , Recombination (2008) (0)
- Abstract 1749: Investigating the role of RAD51AP1 in homologous recombination DNA repair (2019) (0)
- Molecular Cell Smc 5-Smc 6 Restrains Mph 1 in DNA Fork Processing (2014) (0)
- Human MHF1-MHF2 DNA complex (2014) (0)
- Dual and Opposite Effects of hRAD 51 Chemical Modulation on HIV-1 Integration Graphical (0)
- Erratum for the Report "Base triplet stepping by the Rad51/RecA family of recombinases" (Science (2015) (977-981)) (2015) (0)
- Fanci-FANCD2 Promotes Genome Stability and DNA Repair By Down-Regulating BLM Helicase Activity (2021) (0)
- Faculty Opinions recommendation of H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (2020) (0)
- HUMAN RAD51 INHIBITS THE HIV-1 INTEGRATION STEP: STUDY OF THE IN VITRO MECHANISM USING STREPTAVIDIN MAGNETIC BEADS (2010) (0)
- Mutation ofcysteine-88 intheSaccharomyces cerevisiae RAD6 protein abolishes itsubiquitin-conjug ating (1990) (0)
- FANCI-FANCD2 Binds RNA, Which Stimulates Its Monoubiquitination (2018) (0)
- Biochemical Analysis of RNA-DNA Hybrid and R-Loop Unwinding Via Motor Proteins. (2022) (0)
- The Role of UAF1 in the Fanconi Anemia Pathway Regulation of Homologous Recombination-Mediated Genome Maintenance (2016) (0)
- Interactions Among Brca1, Brca2, and Components of the Recombination Machinery (1999) (0)
- Crystal structure of human RMI1 N-terminus (2010) (0)
- Molecular Basis for Enhancement of the Meiotic DMCI Recombinase by RAD51AP1 (2011) (0)
- UAF1 DNA Binding Activity Is Critical for RAD51-Mediated Homologous DNA Pairing (2019) (0)
- Abstract 2063: TLK1 phosphorylates RAD54 to promote homology driven DSB repair (2021) (0)
- A Rare Cell-penetrating Anti-DNA Antibody Inhibits DNA Repair, Sensitizes Tumors To DNA-damaging Therapy, and is Synthetically Lethal to BRCA2-deficient Cancer Cells (2012) (0)
- Homologous Genetic Recombination in Eukaryotes (2001) (0)
- Crystal structure of human RMI1C-RMI2 complex (2010) (0)
- A Role for Splicing Factors and R-Loop Formation in the Pathophysiology of Fanconi Anemia. (2010) (0)
- Abstract 2046: Binding of FANCD2 to SRSF1 splicing factor prevents genomic instability through R-loop regulation (2021) (0)
- Dissecting the role of the Rad51 paralogs during double‐strand break repair (2016) (0)
- Mechanism and Regulation of the Helicase‐driven Path of DNA End Resection in Saccharomyces cerevisiae (2012) (0)
- New insight into mediator function of yeast Rad52 protein (2005) (0)
- Human MHF1-MHF2 complex (2013) (0)
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