Karl Paul Link
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Most Influential Person Across History
American biochemist
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Biology
Why Is Karl Paul Link Influential?
(Suggest an Edit or Addition)According to Wikipedia, Karl Paul Gerhard Link was an American biochemist best known for his discovery of the anticoagulant warfarin. Training and early career He was born in LaPorte, Indiana to a Lutheran minister of German descent as one of ten children. He was schooled locally, and attended the University of Wisconsin–Madison, where he studied agricultural chemistry at the College of Agriculture from 1918 to 1925, obtaining an MS in 1923 and a PhD in 1925.
Karl Paul Link's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Discovery of Dicumarol and Its Sequels (1959) (336)
- STUDIES ON THE HEMORRHAGIC SWEET CLOVER DISEASE V. IDENTIFICATION AND SYNTHESIS OF THE HEMORRHAGIC AGENT (1941) (234)
- STUDIES ON THE HEMORRHAGIC SWEET CLOVER DISEASE IV. THE ISOLATION AND CRYSTALLIZATION OF THE HEMORRHAGIC AGENT (1941) (204)
- Studies on the 4-Hydroxycoumarins. XVII.1a The Resolution and Absolute Configuration of Warfarin1b (1961) (144)
- CARBOHYDRATE CHARACTERIZATION I. THE OXIDATION OF ALDOSES BY HYPOIODITE IN METHANOL II. THE IDENTIFICATION OF SEVEN ALDO-MONOSACCHARIDES AS BENZIMIDAZOLE DERIVATIVES (1940) (138)
- The isolation of catechol from pigmented Onion scales and its significance in relation to disease resistance in Onions. (1933) (111)
- STUDIES ON THE HEMORRHAGIC SWEET CLOVER DISEASE XI. HYPOPROTHROMBINEMIA IN THE RAT INDUCED BY SALICYLIC ACID (1943) (101)
- Studies on 4-Hydroxycoumarins. V. The Condensation of α,β-Unsaturated Ketones with 4-Hydroxycoumarin1 (1944) (92)
- Warfarin metabolism and vitamin K requirement in the warfarin-resistant rat. (1969) (87)
- STUDIES ON THE HEMORRHAGIC SWEET CLOVER DISEASE II. THE BIOASSAY OF HEMORRHAGIC CONCENTRATES BY FOLLOWING THE PROTHROMBIN LEVEL IN THE PLASMA OF RABBIT BLOOD (1941) (80)
- Studies on the 4-hydroxycoumarins. Synthesis of the metabolites and some other derivatives of warfarin. (1971) (80)
- Studies on the Hemorrhagic Sweet Clover Disease IX. The Effect of Diet and Vitamin K on the Hypopro-Thrombinemia Induced by 3,3???-Methylenebis (4-Hydroxycoumarin) in the RatOne Figure (1942) (80)
- A comparison of the isomers of warfarin (1966) (75)
- Studies on 4-Hydroxycoumarin. VII. Reactions of 4-Hydroxycoumarin with Cationoid Reagents1 (1945) (71)
- THE ISOLATION OF PROTOCATECHUIC ACID FROM PIGMENTED ONION SCALES AND ITS SIGNIFICANCE IN RELATION TO DISEASE RESISTANCE IN ONIONS (1929) (69)
- STUDIES ON THE HEMORRHAGIC SWEET CLOVER DISEASE XIII. ANTICOAGULANT ACTIVITY AND STRUCTURE IN THE 4-HYDROXYCOUMARIN GROUP (1944) (65)
- A METHOD FOR THE DETERMINATION OF URONIC ACIDS1 (1930) (58)
- The metabolism of 4-C14-warfarin sodium by the rat. (1970) (54)
- New Compounds. Substituted Salicylaldehydes and Derivatives (1950) (53)
- The effect of sulfaguanidine on rat growth and plasma prothrombin. (1942) (51)
- Toxicity of Phenolic Compounds to Certain Onion Bulb Parasites (1935) (46)
- Studies on the 4-Hydroxycoumarins. XVIII.1a 3-[α-(Acetamidomethyl)benzyl]-4-hydroxycoumarin and Related Products1b (1962) (45)
- STUDIES ON THE HEMORRHAGIC SWEET CLOVER DISEASE I. THE PREPARATION OF HEMORRHAGIC CONCENTRATES (1940) (45)
- Studies on 4-Hydroxycoumarins. I. The Synthesis of 4-Hydroxycoumarins1 (1943) (44)
- Studies on 4-Hydroxycoumarins. II. The Condensation of Aldehydes with 4-Hydroxycoumarins1 (1943) (44)
- THE METHYLGLYCOSIDES OF THE NATURALLY OCCURRING HEXURONIC ACIDS III. POLYGALACTURONIC ACID-METHYLGLYCOSIDES DERIVED FROM PECTIN (1934) (44)
- Studies on 4-Hydroxycoumarins. XIII. The Mechanism for the Reaction of 4-Hydroxycoumarin with Aliphatic Acid Chlorides1 (1953) (39)
- Studies on the hemorrhagic sweet clover disease. 7. The effect of 3,3' methylenebis (4-hydroxycoumarin) on the prothrombin time of the plasma of various animals. (1942) (37)
- Reductive Cleavage of Benzyl Glycosides for Relating Anomeric Configurations. Preparation of Some New Benzyl Pentosides1 (1951) (37)
- Studies on the hemorrhagic sweet clover disease. 8. The effect of 2-methyl-1, 4-naphthaquinone and l-ascorbic acid upon the action of 3,3'-methylenebis (4-hydroxycoumarin) on the prothrombin time of rabbits. (1942) (34)
- CARBOHYDRATE CHARACTERIZATION V. ANHYDRIZATION OF THE ALDOPENTO-BENZIMIDAZOLES (1945) (32)
- Further observations on the occurrence of protocatechuic acid in pigmented Onion scales and its relation to disease resistance in the Onion. (1929) (31)
- The Nature of Resistance to Seedling Blight of Cereals. (1923) (30)
- The relation of protocatechuic acid to disease resistance in the Onion. (27)
- STUDIES ON THE HEMORRHAGIC SWEET CLOVER DISEASE VI. THE SYNTHESIS OF THE δ-DIKETONE DERIVED FROM THE HEMORRHAGIC AGENT THROUGH ALKALINE DEGRADATION (1941) (27)
- Studies on 4-Hydroxycoumarins. X. Acylation of 3-(α-Phenyl-β-acetylethyl)-4-hydroxycoumarin1 (1950) (24)
- THE METHYLGLYCOSIDES OF THE NATURALLY OCCURRING HEXURONIC ACIDS I. THE PREPARATION OF METHYL-d-GALACTURONIDE (1933) (23)
- Studies on 4-Hydroxycoumarins. XII. 3-Substituted-aminomethyl-4-hydroxycoumarin Derivatives by the Mannich Reaction1 (1953) (22)
- CARBOHYDRATE CHARACTERIZATION IV. IDENTIFICATION OF d-RIBOSE, l-FUCOSE, AND d-DIGITOXOSE AS BENZIMIDAZOLE DERIVATIVES (1943) (21)
- The Synthesis of Various 3-Substituted-4-alkylcoumarins1 (1957) (21)
- A PRECISE METHOD FOR THE DETERMINATION OF COUMARIN, MELILOTIC ACID, AND COUMARIC ACID IN PLANT TISSUE (1937) (21)
- EFFECTS OF THE METHOD OF DESICCATION ON THE CARBOHYDRATES OF PLANT TISSUE1 (1923) (21)
- A NEW SYNTHETIC APPROACH TO SOME 3-ARALKYL-4-HYDROXYCOUMARINS1 (1957) (20)
- CHEMICAL ASPECTS OF DISEASE RESISTANCE IN THE ONION. (1929) (20)
- THE SYNTHESIS OF PREGNANEDIOL 3-β-d-GLUCURONIDE (1944) (17)
- THE ACTION OF WEAK MINERAL ACIDS ON URONIC ACIDS1,2 (1930) (16)
- The principal Alkaloids of Sabadilla Seed and their Toxicity to Musca domestica L. (1945) (16)
- The resolution and absolute configuration of “marcumar” (1965) (15)
- Amino Acid Derivatives of D-Glucosamine1 (1953) (15)
- Acid and Alkaline Hydrolysis Rates and Heats of Activation of Some o- and p-Nitrophenyl Glycosides1 (1952) (15)
- The Synthesis of Some 3-Substituted-4-methylcoumarins1 (1953) (14)
- A MICROMETHOD FOR THE DETERMINATION OF URONIC ACIDS (1934) (14)
- Determination of Coumarin and Melilotic Acid: A Rapid Micromethod for Determination in Melilotus Seed and Green Tissue (1937) (14)
- Benzylidene Derivatives of L-Arabinose Diethyl Acetal and Dimethyl Acetal1 (1950) (13)
- Studies on 4-Hydroxycoumarin. III. Dehydration of the Aldehyde Condensation Products1 (1943) (13)
- THE PREPARATION OF 2-(ALDO-POLYHYDROXYALKYL)-BENZIMIDAZOLES1 (1940) (13)
- STUDIES ON THE HEMORRHAGIC SWEET CLOVER DISEASE XIV. HYPERPROTHROMBINEMIA INDUCED BY METHYLXANTHINES AND ITS EFFECT ON THE ACTION OF 3,3'-METHYLENEBIS-(4-HYDROXYCOUMARIN) (1944) (12)
- DERIVATIVES OF d-GALACTURONIC ACID I. ESTERIFICATION AND ACYLATION OF d-GALACTURONIC ACID (1935) (12)
- The Preparation and Alkali Sensitivity of Some New Enol Glucosides and Glucosides of β-Hydroxy Carbonyl Compounds1 (1950) (11)
- Studies on 4-Hydroxycoumarins. XI. Cyclic Ketals of 3-(α-Acetonylbenzyl)-4-hydroxycoumarin1 (1952) (11)
- Synthesis of Glycol Glucosides1 (1940) (11)
- Studies on 4-Hydroxycoumarins. XIV. The Reaction of 4-Hydroxycoumarin with Aromatic Acid Chlorides1 (1953) (11)
- The J substance of cattle. V. Immunochemical studies of the J substance from bovine gastric mucosa. (1958) (11)
- DERIVATIVES OF d-GALACTURONIC ACID II. THE SYNTHESIS OF α-ACETOBROMO-d-GALACTURONIC ACID METHYL ESTER AND ITS CONVERSION TO β-METHYL-d-GALACTURONIDE (1935) (10)
- The Relative Effectiveness of the Principal Alkaloids of Sabadilla Seed (1945) (10)
- CARBOHYDRATE CHARACTERIZATION III. THE IDENTIFICATION OF HEXURONIC OR SACCHARIC ACIDS AS BENZIMIDAZOLE DERIVATIVES (1942) (10)
- ISOLATION OF α- AND β, d-MANNURONIC ACID (1933) (9)
- The Preparation of d-Galacturonic Acid from d-Galactose1 (1938) (9)
- THE METHYLGLYCOSIDES OF THE NATURALLY OCCURRING HEXURONIC ACIDS IV. POLYGALACTURONIC ACID-METHYLGLYCOSIDES DERIVED FROM EHRLICH'S "PEKTOLSÄURE" AND "PEKTOLACTONSÄURE" (1935) (9)
- Interaction of 1,3,4,6-Tetraacetyl-β-D-glucosamine with Acyl Amino Acid Azides1 (1953) (9)
- Studies on 4-Hydroxycoumarins. XV. Synthesis of Some 3-Thio-4-hydroxycoumarins from 3-Bromo-4-hydroxycoumarin1 (1954) (8)
- The Mutarotation and Rotatory Dispersion of Derivatives of Aldehydo-d-galacturonic Acid1 (1940) (8)
- Studies on 4-Hydroxycoumarin. VIII. Phenylhydrazine Degradation of 3,3'-Methylenebis-(4-hydroxycoumarin)1 (1945) (7)
- NOTE ON THE PREPARATION OF d-GALACTURONIC ACID IN LARGE QUANTITY (1934) (7)
- IMPROVEMENTS IN THE PREPARATION OF d-GALACTURONIC ACID (1931) (7)
- Studies on the hemorrhagic sweet clover disease. 10. Induced vitamin C excretion in the rat and its effect on the hypoprothrombinemia caused by 3,3'-methylenebis(4-hydroxycoumarin). (1942) (7)
- Studies on 4-Hydroxycoumarins. IX. The Condensation of Chloral with 4-Hydroxycoumarin and the Mechanism of Aldehyde Condensations with 4-Hydroxycoumarin1 (1950) (7)
- Hypoprothrombinemia induced in the dog by salicylic acid. (1949) (6)
- EFFECTS OF THE METHOD OF DESICCATION ON THE NITROGENOUS CONSTITUENTS OF PLANT TISSUE1 (1924) (6)
- The anticoagulant 3, 3'-methylenebis (4-hydroxycoumarin). (1945) (6)
- NOTE ON THE REACTION OF d-GLUCOSAMINE WITH o-PHENYLENEDIAMINE (1943) (6)
- Preparation and Characterization by Alkaline Methanolysis of 5,5-Diethyl-4-(tetraacetyl-β-D-glucosyloxy)-2,6(1,5)-pyrimidinedione1 (1953) (6)
- INCREASED PLASMA FIBRINOGEN INDUCED BY METHYLXANTHINES (1945) (6)
- Alkaline Methanolysis of Theobromine β-D-Glucoside Tetraacetate (1949) (6)
- The Decarboxylation of Methyl Diacetyl-L-threuronate1 (1950) (6)
- Report on the emetic substances in Gibberella-infected Barley. (6)
- THE METHYLGLYCOSIDES OF THE NATURALLY OCCURRING HEXURONIC ACIDS II. THE KINETICS OF THE HYDROLYSIS OF α-METHYL-d-GALACTURONIDE (1934) (6)
- SUBSTITUTED HYDRAZINE DERIVATIVES OF THE HEXURONIC ACIDS PHENYLHYDRAZINE AND p-BROMOPHENYLHYDRAZINE DERIVATIVES OF d-GALACTURONIC ACID AND p-BROMOPHENYLHYDRAZINE DERIVATIVES OF d-MANNURONIC ACID (1933) (6)
- Periodate Oxidation of D-Glucosazone (1950) (6)
- Synthesis of the hexuronic acids. 6. The synthesis of l-galacturonic acid from l-galactose. (1934) (5)
- ACETALS IN THE SUGAR GROUP I. THE DIMETHYL ACETAL OF d-GALACTOSE (1938) (5)
- Studies on 4-Hydroxycoumarins. XVI. The Metabolism of 4-Hydroxycoumarin in the Dog1 (1954) (5)
- THE PREPARATION OF d-MANNURONIC ACID LACTONE (1932) (5)
- DERIVATIVES OF d-GALACTURONIC ACID IV. THE PREPARATION OF THE METHYL ESTER OF d-GALACTURONIC ACID (1938) (4)
- THE CHEMICAL COMPOSITION OF CORN (ZEA MAYS) SEEDLINGS. I. THE ISOLATION OF XYLAN AND CELLULOSE FROM THE CELL WALLS1,2 (1929) (4)
- Temperature Coefficients of Rotation of Some o-and p-Nitrophenyl Glycosides and their Polyacetates1 (1953) (4)
- Cyclic oxalic and phthalic esters of d-glucose (1979) (4)
- ISOLATION AND DETERMINATION OF STARCH IN PLANT TISSUE. (1935) (4)
- Note on hyperprothrombinemia induced by vitamin K. (1944) (4)
- Prothrombin and fibrinogen deficiency in newborn pups and lambs. (1951) (4)
- Brominated 4-Hydroxycoumarins (1944) (4)
- SYNTHESIS OF THE HEXURONIC ACIDS I. THE SYNTHESIS OF dl-GALACTURONIC ACID FROM MUCIC ACID (1932) (4)
- cis-trans Enolic β-D-Glycosides of Methyl Acetoacetate1 (1951) (4)
- SYNTHESIS OF THE HEXURONIC ACIDS II. THE SYNTHESIS OF d-MANNURONIC ACID FROM d-MANNOSACCHARIC ACID (1934) (3)
- Alkali-sensitive Glycosides of 3-Phenyl-4-hydroxycoumarin (1949) (3)
- THE CHARACTERIZATION OF LACTIC ACID AS THE BENZIMIDAZOLE DERIVATIVE (1942) (3)
- DERIVATIVES OF d-GALACTURONIC ACID V. THE SYNTHESIS OF THE METHYL ESTERS OF CHOLESTEROL, SITOSTEROL, AND ERGOSTEROL TRIACETYL-d-GALACTURONIDES (1938) (3)
- THE PREPARATION OF d-GALACTURONIC ACID FROM LEMON PECTIC ACID (1930) (3)
- Determination of Proportion of d- and l-Isomers in Samples of Lactic Acid (1941) (3)
- The mechanism of warfarin formation from 4-hydroxycoumarin and β-anilinobenzylacetone. Evidence for schiff base intermediates showing enhanced reactivity in the Michael reaction (1960) (3)
- Studies on 4-Hydroxycoumarins. VI. Glucosides of 4-Hydroxycoumarins1 (1944) (3)
- THE COMPOSITION OF AN ALDOBIONIC ACID FROM FLAXSEED MUCILAGE (1934) (3)
- Kinetics of the Acid and Enzyme Hydrolysis of cis-trans Enolic D-Glucosides and D-Galactosides of Methyl Acetoacetate1 (1952) (2)
- Preparation of Methyl d-Galacturonide (1932) (2)
- Prothrombin Activity in Rats with Hepatic and Other Tumors (1944) (2)
- THE ISOLATION AND CHARACTERIZATION OF A STARCH POLYSACCHARIDE FROM THE WOODY TISSUE OF THE APPLE TREE (MALUS MALUS) (1935) (2)
- NOTE ON THE PREPARATION OF SINIGRIN (1936) (2)
- The anticoagulant dicumarol. (1948) (1)
- The effect of methylxanthines on the hypocoagulability induced by chloroform in the dog. (1952) (1)
- THE CHEMICAL COMPOSITION OF CORN (ZEA MAYS) SEEDLINGS. II. THE ISOLATION OF A DEXTRIN SIMILAR TO THE TRIHEXOSAN OBTAINED BY THE THERMAL DEPOLYMERIZATION OF POTATO STARCH (1929) (1)
- SYNTHESIS OF THE HEXURONIC ACIDS III. THE SYNTHESIS OF dl-ALLURONIC ACID FROM ALLOMUCIC ACID (1934) (1)
- CRYSTALLINE d-MANNURONIC ACID. (1932) (1)
- Studies on 4-Hydroxycoumarins. IV. Esters of the 4-Hydroxycoumarins1 (1944) (1)
- Correction. Studies on 4-Hydroxycoumarin. VIII. Phenylhydrzine, Degradation of 3,3'-Methylenebis-(4-hydroxycoumarin). (1945) (1)
- SYNTHESIS OF THE HEXURONIC ACIDS VII. THE SYNTHESIS OF l-GLUCURONIC ACID AND THE RESOLUTION OF dl-GALACTURONIC ACID (1934) (1)
- The hypoprothrombinemic action of the salicylates. (1948) (1)
- Postcard from Karl Paul Link to Joshua Lederberg (1953) (0)
- Carbohydrate characterization. VI. Synthesis of an anhydroaldopentobenzimidazole. (1950) (0)
- Note on plasma fibrinogen in guinea pig scurvy. (1944) (0)
- Can we look forward to better anticoagulants than heparin and dicumarol? (1949) (0)
- Letter from Karl Paul Link to C. A. Elvehjem (1959) (0)
- Letter from Karl Paul Link to Joshua Lederberg (1959) (0)
- THE ELEMENTARY COMPOSITION OF THE PENTOSAN XYLAN1,2 (1930) (0)
- Crystalline d-Mannuronic Acid (1932) (0)
- Hermann O. L. Fischer: a tribute on his 70th birthday. Preceding. (1958) (0)
- Note on the bornyl ester of bornyl d-glucuronide. (1950) (0)
- Letter from Karl Paul Link to the University of Wisconsin (1948) (0)
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