Chris Dobson
#13,971
Most Influential Person Now
British chemist
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Chemistry
Chris Dobson's Degrees
- PhD Chemistry University of Oxford
- Bachelors Chemistry University of Oxford
Why Is Chris Dobson Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sir Christopher Martin Dobson was a British chemist, who was the John Humphrey Plummer Professor of Chemical and Structural Biology in the Department of Chemistry at the University of Cambridge, and Master of St John's College, Cambridge.
Chris Dobson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Protein misfolding, functional amyloid, and human disease. (2006) (5662)
- Protein folding and misfolding (2003) (4253)
- Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases (2002) (2412)
- Protein misfolding, evolution and disease. (1999) (1845)
- Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution (2003) (1560)
- Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade. (2017) (1540)
- Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism (2013) (1037)
- Rationalization of the effects of mutations on peptide andprotein aggregation rates (2003) (1018)
- Designing conditions for in vitro formation of amyloid protofilaments and fibrils. (1999) (1011)
- Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis (1997) (984)
- The amyloid state and its association with protein misfolding diseases (2014) (984)
- An Analytical Solution to the Kinetics of Breakable Filament Assembly (2009) (959)
- The amyloid state and its association with protein misfolding diseases (2014) (903)
- The structural basis of protein folding and its links with human disease. (2001) (898)
- Hydrodynamic radii of native and denatured proteins measured by pulse field gradient NMR techniques. (1999) (888)
- Principles of protein folding, misfolding and aggregation. (2004) (883)
- Chemical space and biology (2004) (809)
- The protofilament structure of insulin amyloid fibrils (2002) (801)
- Amyloid formation by globular proteins under native conditions. (2009) (768)
- Amyloid fibrils from muscle myoglobin (2001) (746)
- Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein (2012) (725)
- The folding of hen lysozyme involves partially structured intermediates and multiple pathways (1992) (668)
- Protein Folding: A Perspective from Theory and Experiment. (1998) (666)
- Role of Intermolecular Forces in Defining Material Properties of Protein Nanofibrils (2007) (657)
- Simultaneous determination of protein structure and dynamics (2005) (650)
- Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations. (2005) (605)
- Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases. (2005) (576)
- Characterization of the nanoscale properties of individual amyloid fibrils (2006) (572)
- Long-Range Interactions Within a Nonnative Protein (2002) (552)
- A causative link between the structure of aberrant protein oligomers and their toxicity. (2010) (513)
- Protein structure determination from NMR chemical shifts (2007) (512)
- The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation (2002) (495)
- Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation (2014) (494)
- Cryo‐electron microscopy structure of an SH3 amyloid fibril and model of the molecular packing (1999) (492)
- Effects of macromolecular crowding on protein folding and aggregation (1999) (492)
- Understanding protein folding via free-energy surfaces from theory and experiment. (2000) (476)
- Detection of transient protein folding populations by mass spectrometry. (1993) (467)
- High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy. (2004) (464)
- Atomic structure and hierarchical assembly of a cross-β amyloid fibril (2013) (453)
- Formation of insulin amyloid fibrils followed by FTIR simultaneously with CD and electron microscopy (2000) (451)
- Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation. (2015) (448)
- Prediction of aggregation-prone regions in structured proteins. (2008) (443)
- Molecular mechanisms of protein aggregation from global fitting of kinetic models (2016) (430)
- Characterization of a partly folded protein by NMR methods: studies on the molten globule state of guinea pig alpha-lactalbumin. (1989) (422)
- The fundamentals of protein folding: bringing together theory and experiment. (1999) (420)
- Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR (2004) (416)
- Three key residues form a critical contact network in a protein folding transition state (2001) (413)
- Kinetic partitioning of protein folding and aggregation (2002) (404)
- Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers (2017) (398)
- From macroscopic measurements to microscopic mechanisms of protein aggregation. (2012) (397)
- Formation and seeding of amyloid fibrils from wild-type hen lysozyme and a peptide fragment from the beta-domain. (2000) (392)
- Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation (2015) (382)
- Prefibrillar Amyloid Protein Aggregates Share Common Features of Cytotoxicity* (2004) (381)
- De novo designed peptide-based amyloid fibrils (2002) (362)
- Metastability of native proteins and the phenomenon of amyloid formation. (2011) (357)
- Molecular recycling within amyloid fibrils (2005) (349)
- Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides (2014) (347)
- The characterization of hardened alkali-activated blast-furnace slag pastes and the nature of the calcium silicate hydrate (C-S-H) phase (1994) (346)
- Analysis of main chain torsion angles in proteins: prediction of NMR coupling constants for native and random coil conformations. (1996) (328)
- Widespread Proteome Remodeling and Aggregation in Aging C. elegans (2015) (328)
- ANS binding reveals common features of cytotoxic amyloid species. (2010) (326)
- Resolution enhancement of protein PMR spectra using the difference between a broadened and a normal spectrum (1973) (326)
- Direct Observation of the Three Regions in α-Synuclein that Determine its Membrane-Bound Behaviour (2014) (320)
- Understanding how proteins fold: the lysozyme story so far. (1994) (316)
- Prediction of the absolute aggregation rates of amyloidogenic polypeptide chains. (2004) (309)
- The importance of sequence diversity in the aggregation and evolution of proteins (2005) (307)
- Widespread Proteome Remodeling and Aggregation in Aging C. elegans (2017) (304)
- The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures (2007) (303)
- Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments. (2011) (291)
- Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering (2010) (290)
- Probing the Nature of Noncovalent Interactions by Mass Spectrometry. A Study of Protein−CoA Ligand Binding and Assembly (1996) (289)
- Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy. (2009) (278)
- The concept of a random coil. Residual structure in peptides and denatured proteins. (1996) (277)
- Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases (2002) (274)
- Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding (1999) (272)
- Life on the edge: a link between gene expression levels and aggregation rates of human proteins. (2007) (271)
- Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments (2003) (269)
- Location of Aluminum in Substituted Calcium Silicate Hydrate (C‐S‐H) Gels as Determined by 29Si and 27Al NMR and EELS (1993) (266)
- The molecular chaperone Brichos breaks the catalytic cycle that generates toxic Aβ oligomers (2015) (261)
- Structural and dynamical properties of a denatured protein. Heteronuclear 3D NMR experiments and theoretical simulations of lysozyme in 8 M urea. (1997) (260)
- Characterization of the oligomeric states of insulin in self-assembly and amyloid fibril formation by mass spectrometry. (2000) (259)
- Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease (2016) (254)
- Macromolecular crowding perturbs protein refolding kinetics: implications for folding inside the cell (2000) (254)
- A highly amyloidogenic region of hen lysozyme. (2004) (245)
- A partially folded state of hen egg white lysozyme in trifluoroethanol: structural characterization and implications for protein folding. (1993) (244)
- Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case. (2004) (244)
- A residue-specific NMR view of the non-cooperative unfolding of a molten globule (1997) (243)
- Structure and dynamics of the acid-denatured molten globule state of alpha-lactalbumin: a two-dimensional NMR study. (1993) (242)
- The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide (2011) (241)
- Protein-misfolding diseases: Getting out of shape (2002) (241)
- Prefibrillar Amyloid Aggregates Could Be Generic Toxins in Higher Organisms (2006) (240)
- Heat Shock Protein 70 Inhibits α-Synuclein Fibril Formation via Preferential Binding to Prefibrillar Species* (2005) (239)
- Mutational analysis of the propensity for amyloid formation by a globular protein (2000) (232)
- Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril (2002) (229)
- A kinetic study of β‐lactoglobulin amyloid fibril formation promoted by urea (2002) (228)
- A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme (2003) (226)
- Observation of sequence specificity in the seeding of protein amyloid fibrils (2004) (226)
- Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins. (2013) (221)
- Demonstration by NMR of folding domains in lysozyme (1991) (219)
- Sequential 1H NMR assignments and secondary structure of hen egg white lysozyme in solution. (1988) (218)
- The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation. (2014) (217)
- Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme (2002) (216)
- Structural Reorganisation and Potential Toxicity of Oligomeric Species Formed during the Assembly of Amyloid Fibrils (2007) (210)
- The formation of spherulites by amyloid fibrils of bovine insulin. (2004) (209)
- Differential Phospholipid Binding of α-Synuclein Variants Implicated in Parkinson’s Disease Revealed by Solution NMR Spectroscopy† (2009) (208)
- Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation (2016) (208)
- Following protein folding in real time using NMR spectroscopy (1995) (204)
- Progressive Changes in the Structure of Hardened C3S Cement Pastes due to Carbonation (1991) (201)
- A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity (2017) (199)
- Atmospheric aerosols as prebiotic chemical reactors. (2000) (196)
- Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein (2016) (194)
- Dependence on solution conditions of aggregation and amyloid formation by an SH3 domain. (2001) (194)
- Direct characterization of amyloidogenic oligomers by single-molecule fluorescence (2008) (190)
- Systematic In Vivo Analysis of the Intrinsic Determinants of Amyloid β Pathogenicity (2007) (188)
- Ultrastructural organization of amyloid fibrils by atomic force microscopy. (2000) (187)
- Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation (2016) (187)
- Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass (2007) (186)
- Amyloid fibril formation by bovine milk kappa-casein and its inhibition by the molecular chaperones alphaS- and beta-casein. (2005) (186)
- Detection and selective dissociation of intact ribosomes in a mass spectrometer. (2000) (185)
- Determination of the free energy landscape of alpha-synuclein using spin label nuclear magnetic resonance measurements. (2009) (185)
- Amyloid Fibril Formation by Lens Crystallin Proteins and Its Implications for Cataract Formation* (2004) (182)
- Chemical kinetics for drug discovery to combat protein aggregation diseases. (2014) (181)
- Protein misfolding and disease: from the test tube to the organism. (2008) (180)
- Structural determinants of protein dynamics: analysis of 15N NMR relaxation measurements for main-chain and side-chain nuclei of hen egg white lysozyme. (1995) (180)
- Conformation of GroEL-bound α-lactalbumin probed by mass spectrometry (1994) (180)
- Characterisation of protein unfolding by NMR diffusion measurements (1997) (179)
- Different subdomains are most protected from hydrogen exchange in the molten globule and native states of human alpha-lactalbumin. (1995) (178)
- Structure and stability of the molten globule state of guinea-pig alpha-lactalbumin: a hydrogen exchange study. (1993) (175)
- Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading (2016) (173)
- α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling* (2013) (168)
- Ostwald’s rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers (2014) (168)
- Unfolded proteins, compact states and molten globules: Current Opinion in Structural Biology 1992, 2:6–12 (1992) (168)
- Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease (2016) (167)
- Functionalised amyloid fibrils for roles in cell adhesion. (2008) (167)
- An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease (2016) (165)
- Structural basis of synaptic vesicle assembly promoted by α-synuclein (2016) (164)
- Probing the pressure-temperature stability of amyloid fibrils provides new insights into their molecular properties. (2006) (164)
- Mechanistic studies of the folding of human lysozyme and the origin of amyloidogenic behavior in its disease-related variants. (1999) (161)
- Protein Folding Monitored at Individual Residues During a Two-Dimensional NMR Experiment (1996) (161)
- Intermolecular structure determination of amyloid fibrils with magic-angle spinning and dynamic nuclear polarization NMR. (2011) (160)
- A refined solution structure of hen lysozyme determined using residual dipolar coupling data (2001) (159)
- Half a century of amyloids: past, present and future. (2020) (159)
- Exploring amyloid formation by a de novo design. (2004) (159)
- Protein amyloids develop an intrinsic fluorescence signature during aggregation. (2013) (158)
- Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations. (2011) (158)
- Protein aggregation and its consequences for human disease. (2006) (155)
- Determination of an ensemble of structures representing the denatured state of the bovine acyl-coenzyme a binding protein. (2004) (154)
- Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers (2012) (153)
- Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity. (2014) (152)
- Experimental investigation of protein folding and misfolding. (2004) (152)
- Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy (2013) (151)
- Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes (2018) (150)
- Investigation of protein folding by mass spectrometry (1996) (150)
- Structure and properties of a complex of α-synuclein and a single-domain camelid antibody. (2010) (148)
- In situ measurements of the formation and morphology of intracellular β-amyloid fibrils by super-resolution fluorescence imaging. (2011) (147)
- Amyloid fibril formation can proceed from different conformations of a partially unfolded protein. (2005) (145)
- Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry. (1998) (144)
- Identification of the core structure of lysozyme amyloid fibrils by proteolysis. (2006) (144)
- Hydrogen exchange in native and denatured states of hen egg‐white lysozyme (1992) (144)
- Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms (2019) (144)
- Formation of mixed fibrils demonstrates the generic nature and potential utility of amyloid nanostructures (2000) (143)
- Altered aggregation properties of mutant γ‐crystallins cause inherited cataract (2002) (143)
- Cytochrome display on amyloid fibrils. (2006) (139)
- Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation. (2011) (139)
- Proline isomerism in staphylococcal nuclease characterized by NMR and site-directed mutagenesis (1987) (139)
- A Partially Structured Species of β2-Microglobulin Is Significantly Populated under Physiological Conditions and Involved in Fibrillogenesis* (2001) (138)
- The crystal structure of the catalytic domain of human urokinase-type plasminogen activator. (1995) (138)
- Rapid collapse and slow structural reorganisation during the refolding of bovine alpha-lactalbumin. (1999) (137)
- Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide (2020) (136)
- Observation of spatial propagation of amyloid assembly from single nuclei (2011) (136)
- Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases. (2015) (135)
- A Label-Free, Quantitative Assay of Amyloid Fibril Growth Based on Intrinsic Fluorescence (2013) (135)
- The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation (2010) (134)
- Protein Folding and Disease: a view from the first Horizon Symposium (2003) (133)
- Interaction of the Molecular Chaperone DNAJB6 with Growing Amyloid-beta 42 (Aβ42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation* (2014) (133)
- The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model. (2016) (132)
- MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin (1999) (132)
- From Computer Simulations to Human Disease Emerging Themes in Protein Folding (1999) (131)
- Hydration of Tricalcium Silicate Followed by 29Si NMR with Cross‐Polarization (1988) (131)
- Structure of hen lysozyme in solution. (1993) (131)
- Nature and significance of the interactions between amyloid fibrils and biological polyelectrolytes. (2006) (127)
- Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/α‐synuclein complex by Hip (2009) (126)
- Protein folding and misfolding: a paradigm of self–assembly and regulation in complex biological systems (2003) (126)
- Evidence for a mechanism of amyloid formation involving molecular reorganisation within native-like precursor aggregates. (2005) (126)
- Temperature dependent molecular motion of a tyrosine residue of ferrocytochrome C (1976) (125)
- Human interleukin 4. The solution structure of a four-helix bundle protein. (1992) (125)
- Folding of a four-helix bundle: studies of acyl-coenzyme A binding protein. (1995) (125)
- Preparation and characterization of purified amyloid fibrils. (2001) (124)
- Characterization of conformational preferences in a partly folded protein by heteronuclear NMR spectroscopy: assignment and secondary structure analysis of hen egg-white lysozyme in trifluoroethanol. (1995) (124)
- Structural characterization of a highly–ordered ‘molten globule’ at low pH (1994) (124)
- A Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal Transduction (2008) (124)
- Hen Egg White Lysozyme Expressed in, and Secreted from, Aspergillus niger is Correctly Processed and Folded (1990) (123)
- Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions. (2011) (122)
- Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy (2007) (122)
- Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease (2014) (122)
- Toward a Description of the Conformations of Denatured States of Proteins. Comparison of a Random Coil Model with NMR Measurements (1996) (120)
- Amyloid fibril formation by a helical cytochrome (2001) (120)
- The oxidative refolding of hen lysozyme and its catalysis by protein disulfide isomerase (1999) (119)
- Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation. (2018) (119)
- Correlations between 31P n.m.r. chemical shifts and structural parameters in crystalline inorganic phosphates (1986) (119)
- Protein folding on the ribosome. (2010) (119)
- Time-resolved biophysical methods in the study of protein folding. (1996) (119)
- Measurement of the individual pKa values of acidic residues of hen and turkey lysozymes by two-dimensional 1H NMR. (1994) (118)
- Amyloid protofilaments from the calcium-binding protein equine lysozyme: formation of ring and linear structures depends on pH and metal ion concentration. (2003) (118)
- Fourier transform NMR pulse methods for the measurement of slow-exchange rates (1978) (118)
- α-Lactalbumin forms a compact molten globule in the absence of disulfide bonds (1999) (117)
- Solution conditions can promote formation of either amyloid protofilaments or mature fibrils from the HypF N‐terminal domain (2001) (117)
- Protein Folding: A Perspective from Theory and Experiment (1998) (117)
- Structural basis of the stability of a lysozyme molten globule (1995) (116)
- Protein unfolding, amyloid fibril formation and configurational energy landscapes under high pressure conditions. (2006) (116)
- Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping (2016) (116)
- Characterization of the nucleation barriers for protein aggregation and amyloid formation (2007) (115)
- Rare fluctuations of native proteins sampled by equilibrium hydrogen exchange. (2003) (114)
- Hydrophobic clustering in nonnative states of a protein: Interpretation of chemical shifts in NMR spectra of denatured states of lysozyme (1991) (114)
- Three-dimensional structures of translating ribosomes by Cryo-EM. (2004) (114)
- Tertiary interactions in the folding pathway of hen lysozyme: kinetic studies using fluorescent probes. (1994) (114)
- Analysis of phi and chi 1 torsion angles for hen lysozyme in solution from 1H NMR spin-spin coupling constants. (1991) (112)
- A magnetization-transfer nuclear magnetic resonance study of the folding of staphylococcal nuclease. (1989) (111)
- Proton magnetic resonance studies of the tyrosine residues of hen lysozyme-assignment and detection of conformational mobility (1975) (111)
- A structural ensemble of a ribosome-nascent chain complex during co-translational protein folding (2016) (111)
- Ca2+ is a key factor in α-synuclein-induced neurotoxicity (2016) (110)
- Protein Folding: Solid evidence for molten globules (1994) (110)
- Collapse and cooperativity in protein folding. (1996) (109)
- Protein folding and its links with human disease. (2002) (109)
- Bridging the gap: From protein misfolding to protein misfolding diseases (2009) (108)
- A structural study of the hydrophobic box region of lysozyme in solution using nuclear Overhauser effects. (1980) (108)
- Motional averaging of proton nuclear Overhauser effects in proteins. Predictions from a molecular dynamics simulation of lysozyme (1984) (108)
- Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin. (2005) (108)
- Conformational properties of four peptides spanning the sequence of hen lysozyme. (1995) (107)
- Detailed analysis of the energy barriers for amyloid fibril growth. (2012) (107)
- Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation (2009) (107)
- Protein engineering as a strategy to avoid formation of amyloid fibrils (2000) (107)
- The Interaction of the Molecular Chaperone α-Crystallin with Unfolding α-Lactalbumin: A Structural and Kinetic Spectroscopic Study (2002) (106)
- Studies of rare-earth stannates by trin-119 MAS NMR. The use of paramagnetic shift probes in the solid state (1989) (106)
- The refolding of human lysozyme: a comparison with the structurally homologous hen lysozyme. (1994) (105)
- 1H NMR studies of human lysozyme: spectral assignment and comparison with hen lysozyme. (1990) (105)
- Comparison of MD simulations and NMR experiments for hen lysozyme. Analysis of local fluctuations, cooperative motions, and global changes. (1995) (105)
- Characterization of a Trifluoroethanol-induced Partially Folded State of α-Lactalbumin (1994) (105)
- NMR analysis of main-chain conformational preferences in an unfolded fibronectin-binding protein. (1997) (105)
- Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin. (2001) (105)
- Determination of a transition state at atomic resolution from protein engineering data. (2002) (104)
- Protein aggregation and amyloid fibril formation by an SH3 domain probed by limited proteolysis. (2003) (103)
- Amyloid Formation by the Pro-Inflammatory S100A8/A9 Proteins in the Ageing Prostate (2009) (102)
- A Generic Mechanism of Emergence of Amyloid Protofilaments from Disordered Oligomeric Aggregates (2008) (102)
- Reduced global cooperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations. (2005) (102)
- Molecular dynamics simulations of native and substrate-bound lysozyme. A study of the average structures and atomic fluctuations. (1986) (101)
- On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid. (2009) (101)
- Origin of lanthanide nuclear magnetic resonance shifts and their uses (1972) (101)
- Protein microgels from amyloid fibril networks. (2015) (99)
- Protein aggregation in crowded environments. (2010) (98)
- Molecular determinants of the aggregation behavior of α‐ and β‐synuclein (2008) (98)
- Direct Observations of Amyloid β Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1–40) and Aβ(1–42) Aggregation (2014) (98)
- Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates (2019) (98)
- A FRET sensor for non-invasive imaging of amyloid formation in vivo. (2011) (98)
- α2-Macroglobulin and Haptoglobin Suppress Amyloid Formation by Interacting with Prefibrillar Protein Species* (2009) (96)
- High hydrostatic pressure dissociates early aggregates of TTR105-115, but not the mature amyloid fibrils. (2005) (96)
- Protein folding and the organization of the protein topology universe. (2005) (96)
- Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method (2017) (95)
- Mass spectrometry of ribosomes and ribosomal subunits. (1998) (95)
- Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids (2016) (95)
- The Non-Core Regions of Human Lysozyme Amyloid Fibrils Influence Cytotoxicity (2010) (95)
- Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein. (2011) (95)
- Reversal of protein aggregation provides evidence for multiple aggregated States. (2005) (94)
- Transition states for protein folding have native topologies despite high structural variability (2004) (94)
- Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations. (2011) (94)
- Probing the mechanism of amyloidogenesis through a tandem repeat of the PI3-SH3 domain suggests a generic model for protein aggregation and fibril formation. (2006) (93)
- Time development of proton nuclear overhauser effects in proteins (1982) (93)
- Distinct thermodynamic signature of oligomer generation in the aggregation of the amyloid-β peptide (2018) (92)
- Investigating the Effects of Mutations on Protein Aggregation in the Cell* (2005) (91)
- Observation of the noncovalent assembly and disassembly pathways of the chaperone complex MtGimC by mass spectrometry. (2000) (91)
- Dynamic Visions of Enzymatic Reactions (2006) (91)
- Intrinsic disorder modulates protein self-assembly and aggregation (2012) (91)
- Loop mobility in a four-helix-bundle protein: 15N NMR relaxation measurements on human interleukin-4. (1992) (91)
- Protein misfolding diseases : current and emerging principles and therapies (2010) (90)
- Formation of native and non-native interactions in ensembles of denatured ACBP molecules from paramagnetic relaxation enhancement studies. (2005) (90)
- Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases (2016) (90)
- Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy (2009) (90)
- Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage (2014) (89)
- Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants (2015) (89)
- In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells (2013) (89)
- Towards complete descriptions of the free–energy landscapes of proteins (2005) (89)
- Protein solubility and protein homeostasis: a generic view of protein misfolding disorders. (2011) (89)
- Acid-base and tautomeric equilibriums in the solid state: nitrogen-15 NMR spectroscopy of histidine and imidazole (1982) (89)
- Slow folding of muscle acylphosphatase in the absence of intermediates. (1998) (89)
- Yttrium-89 magic angle spinning NMR study of rare-earth pyrochlores: paramagnetic shifts in the solid state (1990) (88)
- A nuclear magnetic resonance study of the hydrogen-exchange behaviour of lysozyme in crystals and solution. (1991) (88)
- Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked Mutants (2010) (88)
- New scenarios of protein folding can occur on the ribosome. (2011) (87)
- Insights into protein folding using physical techniques: studies of lysozyme and alpha-lactalbumin. (1995) (87)
- In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome (2012) (87)
- Characterisation of Amyloid Fibril Formation by Small Heat-shock Chaperone Proteins Human αA-, αB- and R120G αB-Crystallins (2007) (87)
- Acceleration of the folding of acylphosphatase by stabilization of local secondary structure (1999) (87)
- Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS (2017) (86)
- Electrostatic effects in filamentous protein aggregation. (2013) (86)
- The application of high resolution nuclear magnetic resonance to biological systems. (2006) (86)
- Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes (2019) (86)
- The Amyloid Phenomenon and Its Links with Human Disease. (2017) (86)
- Hydrogen exchange properties of proteins in native and denatured states monitored by mass spectrometry and NMR (1997) (86)
- Prediction of variable translation rate effects on cotranslational protein folding (2012) (86)
- Characterization of oligomeric species on the aggregation pathway of human lysozyme. (2009) (86)
- The effects of guanidine hydrochloride on the ’random coil‘ conformations and NMR chemical shifts of the peptide series GGXGG (1997) (85)
- Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes. (2004) (85)
- Conformations of intermediates in the folding of the pancreatic trypsin inhibitor. (1987) (85)
- A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease (2016) (85)
- Multiple conformations of a protein demonstrated by magnetization transfer NMR spectroscopy (1986) (85)
- Fast and slow tracks in lysozyme folding: insight into the role of domains in the folding process. (1997) (84)
- Inversion of the Balance between Hydrophobic and Hydrogen Bonding Interactions in Protein Folding and Aggregation (2011) (84)
- The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species. (2007) (84)
- Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions. (2016) (84)
- The Amyloid Phenomenon and Its Significance in Biology and Medicine. (2019) (84)
- Kinetic consequences of the removal of a disulfide bridge on the folding of hen lysozyme. (1994) (84)
- Sequestration of the Aβ Peptide Prevents Toxicity and Promotes Degradation In Vivo (2010) (83)
- Single Molecule Characterization of the Interactions between Amyloid-β Peptides and the Membranes of Hippocampal Cells (2013) (83)
- Glycine residues appear to be evolutionarily conserved for their ability to inhibit aggregation. (2005) (83)
- Self-templated nucleation in peptide and protein aggregation. (2008) (83)
- Thermodynamic consequences of the removal of a disulphide bridge from hen lysozyme. (1992) (83)
- Getting out of shape. (2002) (82)
- Preconditioning of Microglia by α-Synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation (2013) (82)
- Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers (2012) (82)
- Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of alpha-synuclein aggregation. (2010) (82)
- Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages. (2013) (82)
- Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy. (2013) (81)
- Competition between folding, native-state dimerisation and amyloid aggregation in beta-lactoglobulin. (2009) (81)
- Silk micrococoons for protein stabilisation and molecular encapsulation (2017) (80)
- Chemical dissection and reassembly of amyloid fibrils formed by a peptide fragment of transthyretin. (2000) (80)
- Physical determinants of the self-replication of protein fibrils (2016) (80)
- Formation of amyloid aggregates from human lysozyme and its disease‐associated variants using hydrostatic pressure (2004) (80)
- A clear view of polymorphism, twist, and chirality in amyloid fibril formation. (2013) (80)
- Characterisation of the dominant oxidative folding intermediate of hen lysozyme. (1999) (80)
- Stimulation and inhibition of fibril formation by a peptide in the presence of different concentrations of SDS (2002) (80)
- Towards a structural biology of the hydrophobic effect in protein folding (2016) (80)
- Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers. (2015) (80)
- Amide hydrogen exchange in a highly denatured state. Hen egg-white lysozyme in urea. (1994) (79)
- Structural Characteristics of α-Synuclein Oligomers. (2017) (79)
- Rapid sample-mixing technique for transient NMR and photo-CIDNP spectroscopy: applications to real-time protein folding. (2003) (78)
- Mechanisms of hydrogen exchange in proteins from nuclear magnetic resonance studies of individual tryptophan indole NH hydrogens in lysozyme. (1982) (78)
- Kinetic studies of protein folding using NMR spectroscopy (1998) (78)
- The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity (2018) (78)
- Clusterin facilitates in vivo clearance of extracellular misfolded proteins (2011) (77)
- Partially folded states of equine lysozyme. Structural characterization and significance for protein folding. (1993) (77)
- Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones. (2012) (77)
- Acceleration of the folding of hen lysozyme by trifluoroethanol. (1997) (77)
- Amyloid formation from HypF-N under conditions in which the protein is initially in its native state. (2005) (77)
- Normal and aberrant biological self-assembly: Insights from studies of human lysozyme and its amyloidogenic variants. (2006) (76)
- Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice (2019) (76)
- Spatial persistence of angular correlations in amyloid fibrils. (2006) (76)
- Main-chain dynamics of a partially folded protein: 15N NMR relaxation measurements of hen egg white lysozyme denatured in trifluoroethanol. (1996) (76)
- Population of nonnative states of lysozyme variants drives amyloid fibril formation. (2011) (75)
- Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity (2018) (75)
- Structures and relative free energies of partially folded states of proteins (2003) (75)
- Outline structure of cytochrome c3 and consideration of its properties (1974) (75)
- Transient tertiary structure formation within the ribosome exit port. (2010) (75)
- Understanding the influence of codon translation rates on cotranslational protein folding. (2014) (74)
- Hsp70 Oligomerization Is Mediated by an Interaction between the Interdomain Linker and the Substrate-Binding Domain (2013) (74)
- Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity (2016) (74)
- Proteome-wide observation of the phenomenon of life on the edge of solubility (2019) (73)
- Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions. (2012) (73)
- Independent nucleation and heterogeneous assembly of structure during folding of equine lysozyme. (1999) (72)
- Detergent-like interaction of Congo red with the amyloid beta peptide. (2010) (72)
- The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells (2021) (72)
- Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates (2014) (71)
- Nature and Regulation of Protein Folding on the Ribosome (2019) (71)
- Slow cooperative folding of a small globular protein HPr. (1998) (71)
- In the Footsteps of Alchemists (2004) (70)
- Use of protonless NMR spectroscopy to alleviate the loss of information resulting from exchange-broadening. (2009) (70)
- Kinetic diversity of amyloid oligomers (2020) (70)
- Structure and intermolecular dynamics of aggregates populated during amyloid fibril formation studied by hydrogen/deuterium exchange. (2010) (70)
- Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors. (2010) (70)
- SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation (2015) (70)
- A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation (2016) (70)
- In vitro characterization of lactoferrin aggregation and amyloid formation. (2003) (69)
- Protein Dynamics: Moore's Law in Molecular Biology (2011) (69)
- Transition state contact orders correlate with protein folding rates. (2005) (68)
- X-ray scattering study of the effect of hydration on the cross-beta structure of amyloid fibrils. (2006) (68)
- Nuclear magnetic resonance studies on the structure of lysozyme in solution (1975) (68)
- Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering (2011) (68)
- Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility (2011) (68)
- Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils. (2008) (68)
- Evidence concerning rate-limiting steps in protein folding from the effects of trifluoroethanol (2000) (67)
- The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity (2016) (67)
- Electrostatic effects and hydrogen exchange behaviour in proteins. The pH dependence of exchange rates in lysozyme. (1987) (67)
- Fourier transform proton NMR in H2O. A method for measuring exchange and relaxation rates (1977) (67)
- Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons (2016) (66)
- Stopped-Flow Photo-CIDNP Observation of Protein Folding (1997) (66)
- Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates (2017) (66)
- Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies (2020) (65)
- Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide. (2013) (65)
- Crystal structure of the mutant D52S hen egg white lysozyme with an oligosaccharide product. (1995) (65)
- Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. (2002) (65)
- Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition. (2006) (65)
- Application of Selective 29Si Isotopic Enrichment to Studies of the Structure of Calcium Silicate Hydrate (C‐S‐H) Gels (1994) (65)
- Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. (2018) (65)
- β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces (2016) (64)
- The circularization of amyloid fibrils formed by apolipoprotein C-II. (2003) (64)
- The component polypeptide chains of bovine insulin nucleate or inhibit aggregation of the parent protein in a conformation-dependent manner. (2006) (64)
- 13C-CP/MAS NMR studies of the cyclomalto-oligosaccharide (cyclodextrin) hydrates. (1992) (64)
- A relationship between mRNA expression levels and protein solubility in E. coli. (2009) (64)
- Comparison of the structural and dynamical properties of holo and apo bovine alpha-lactalbumin by NMR spectroscopy. (2001) (63)
- Structural and dynamical characterization of a biologically active unfolded fibronectin-binding protein from Staphylococcus aureus. (1998) (63)
- Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease (2017) (63)
- Protein folding kinetics from magnetization transfer nuclear magnetic resonance (1984) (63)
- Unfolded proteins, compact states and molten globules (1992) (63)
- Structural characterisation and comparison of the native and A-states of equine lysozyme. (1997) (63)
- Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin (2014) (62)
- The Aggregation and Neurotoxicity of TDP-43 and Its ALS-Associated 25 kDa Fragment Are Differentially Affected by Molecular Chaperones in Drosophila (2012) (62)
- Frequency factors in a landscape model of filamentous protein aggregation. (2010) (62)
- Reduction of the amyloidogenicity of a protein by specific binding of ligands to the native conformation (2001) (61)
- Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing (2016) (61)
- Secondary structure and topology of human interleukin 4 in solution. (1991) (61)
- 29Si MAS NMR study of the hydration of tricalcium silicate in the presence of finely divided silica (1988) (60)
- Thermal unfolding of an intermediate is associated with non-Arrhenius kinetics in the folding of hen lysozyme. (2000) (60)
- Disulfide Bonds Reduce the Toxicity of the Amyloid Fibrils Formed by an Extracellular Protein** (2011) (60)
- Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies (2020) (60)
- Paramagnetic ions as structural probes in solid-state NMR: Distance measurements in crystalline lanthanide acetates (1993) (60)
- Formation of amyloid fibrils by peptides derived from the bacterial cold shock protein CspB (1999) (59)
- Sequence-specific 1H NMR assignments and solution structure of bovine pancreatic polypeptide. (1992) (59)
- Antibodies and protein misfolding: From structural research tools to therapeutic strategies. (2014) (59)
- Structural biology: Prying into prions (2005) (59)
- Finding the right fold (1995) (59)
- Immunological features of α-synuclein in Parkinson's disease (2008) (58)
- The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation. (2014) (58)
- Unfolding and aggregation during the thermal denaturation of streptokinase. (2002) (58)
- Multiple tight phospholipid-binding modes of α-synuclein revealed by solution NMR spectroscopy (2009) (58)
- Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values. (2005) (58)
- Multiple subsets of side-chain packing in partially folded states of α-lactalbumins (2005) (57)
- Characterization of protein folding intermediates (1991) (57)
- The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases (2018) (56)
- Side-chain conformations in an unfolded protein: chi1 distributions in denatured hen lysozyme determined by heteronuclear 13C, 15N NMR spectroscopy. (1999) (56)
- Dissection of multi‐protein complexes using mass spectrometry: Subunit interactions in transthyretin and retinol‐binding protein complexes (1998) (56)
- An equilibrium partially folded state of human lysozyme at low pH. (1995) (56)
- High-resolution solid-state tin-119 nuclear magnetic resonance spectroscopy of ternary tin oxides (1989) (56)
- Response of native and denatured hen lysozyme to high pressure studied by (15)N/(1)H NMR spectroscopy. (2001) (56)
- Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale (2018) (55)
- High-resolution MAS NMR analysis of PI3-SH3 amyloid fibrils: backbone conformation and implications for protofilament assembly and structure . (2010) (55)
- A Simple Lattice Model That Captures Protein Folding, Aggregation and Amyloid Formation (2014) (55)
- A three-disulphide derivative of hen lysozyme. Structure, dynamics and stability. (1991) (55)
- Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species (2017) (55)
- A new two-disulphide intermediate in the refolding of reduced bovine pancreatic trypsin inhibitor. (1984) (55)
- A Relationship between the Transient Structure in the Monomeric State and the Aggregation Propensities of α-Synuclein and β-Synuclein (2014) (55)
- Real-Time NMR Studies of Protein Folding (1998) (54)
- Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers (2018) (54)
- The domain organization of streptokinase: Nuclear magnetic resonance, circular dichroism, and functional characterization of proteolytic fragments (1996) (54)
- Vicinal coupling constants and protein dynamics. (1985) (54)
- Clusterin facilitates in vivo clearance of extracellular misfolded proteins. (2011) (54)
- Local Cooperativity in an Amyloidogenic State of Human Lysozyme Observed at Atomic Resolution (2010) (54)
- Exploration of partially unfolded states of human α-lactalbumin by molecular dynamics simulation (2001) (53)
- Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease (2019) (53)
- Physicochemical determinants of chaperone requirements. (2010) (53)
- Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson’s disease model (2018) (53)
- Native-State Stability Determines the Extent of Degradation Relative to Secretion of Protein Variants from Pichia pastoris (2011) (52)
- Chemical biology: More charges against aggregation (2007) (52)
- Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies * (2016) (52)
- Detection of residue contacts in a protein folding intermediate. (1997) (52)
- Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: calculation of tertiary structure using systematic homologous model building, dynamical simulated annealing, and restrained molecular dynamics. (1992) (52)
- Chemical modification of insulin in amyloid fibrils (2003) (51)
- Similarities in the thermodynamics and kinetics of aggregation of disease‐related Aβ(1–40) peptides (2007) (51)
- Probing the origins, diagnosis and treatment of amyloid diseases using antibodies. (2004) (51)
- Nucleated Polymerisation in the Presence of Pre-Formed Seed Filaments (2011) (51)
- Stabilisation of alpha-helices by site-directed mutagenesis reveals the importance of secondary structure in the transition state for acylphosphatase folding. (2000) (50)
- Effects of the known pathogenic mutations on the aggregation pathway of the amyloidogenic peptide of apolipoprotein A-I. (2011) (50)
- Protein folding and misfolding inside and outside the cell (1998) (50)
- Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide. (2010) (50)
- Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor (2016) (50)
- Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity. (2015) (49)
- The interaction of the molecular chaperone alpha-crystallin with unfolding alpha-lactalbumin: a structural and kinetic spectroscopic study. (2002) (49)
- Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide (2019) (49)
- Measurement of hydrogen exchange rates using 2D NMR spectroscopy (1986) (49)
- Recombinant amyloid beta-peptide production by coexpression with an affibody ligand (2008) (49)
- Dynamics of the multidomain fibrinolytic protein urokinase from two-dimensional NMR (1989) (48)
- Position‐Dependent Electrostatic Protection against Protein Aggregation (2009) (48)
- Assignment of the 1H n.m.r. spectra of proteins (1975) (48)
- Enthalpic and entropic contributions mediate the role of disulfide bonds on the conformational stability of Interleukin‐4 (2006) (48)
- Twisting transition between crystalline and fibrillar phases of aggregated peptides. (2012) (47)
- Structural characterization of the transition state for folding of muscle acylphosphatase. (1998) (46)
- Chemical shift tensor analyses and simulations of slow-spinning MAS NMR spectra (1986) (46)
- Conformational stability of muscle acylphosphatase: the role of temperature, denaturant concentration, and pH. (1998) (46)
- Scaling behaviour and rate-determining steps in filamentous self-assembly† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01965c Click here for additional data file. (2017) (46)
- Expression in Drosophila of Tandem Amyloid β Peptides Provides Insights into Links between Aggregation and Neurotoxicity* (2012) (46)
- Physical Determinants of Amyloid Assembly in Biofilm Formation (2019) (46)
- Surface attachment of protein fibrils via covalent modification strategies. (2010) (46)
- Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies (2015) (46)
- Clusterin protects neurons against intracellular proteotoxicity (2017) (46)
- Studies of exchangeable hydrogens in lysozyme by means of Fourier transform proton magnetic resonance (1975) (45)
- SAR by kinetics for drug discovery in protein misfolding diseases (2018) (45)
- Impact of the native‐state stability of human lysozyme variants on protein secretion by Pichia pastoris (2006) (45)
- Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication (2017) (45)
- Biosensor‐based label‐free assays of amyloid growth (2009) (45)
- Assignment of the FormulaH n.m.r. Spectra of Proteins [and Discussion] (1975) (45)
- Study of the tryptophan residues of lysozyme using 1H nuclear magnetic resonance. (1978) (45)
- Proton nuclear Overhauser effects and protein dynamics (1981) (45)
- DETECTION OF A MONOMERIC INTERMEDIATE ASSOCIATED WITH DIMERIZATION OF PROTEIN HU BY MASS SPECTROMETRY (1998) (45)
- Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements. (2008) (45)
- Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species. (2017) (45)
- Folding and Aggregation Are Selectively Influenced by the Conformational Preferences of the α-Helices of Muscle Acylphosphatase* (2001) (44)
- Studies of beta-sheet structure in lysozyme by proton nuclear magnetic resonance. Assignments and analysis of spin-spin coupling constants. (1982) (44)
- Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery (2018) (44)
- High-sensitivity fluorescence anisotropy detection of protein-folding events: application to alpha-lactalbumin. (2001) (44)
- Probing side-chain dynamics of a ribosome-bound nascent chain using methyl NMR spectroscopy. (2009) (44)
- The origin of the alpha-domain intermediate in the folding of hen lysozyme. (1998) (44)
- Hydrophobicity and conformational change as mechanistic determinants for nonspecific modulators of amyloid β self-assembly. (2012) (44)
- 1H-NMR assignments and local environments of aromatic residues in bovine, human and guinea pig variants of alpha-lactalbumin. (1992) (44)
- A toy model for predicting the rate of amyloid formation from unfolded protein. (2005) (44)
- A molecular dynamics analysis of protein structural elements (1989) (44)
- Label-free detection of amyloid growth with microcantilever sensors (2008) (43)
- A kinetic study of beta-lactoglobulin amyloid fibril formation promoted by urea. (2002) (43)
- Comparison of the refolding of hen lysozyme from dimethyl sulfoxide and guanidinium chloride. (1995) (43)
- Importance of metastable states in the free energy landscapes of polypeptide chains. (2007) (43)
- Lithostathine Quadruple-helical Filaments Form Proteinase K-resistant Deposits in Creutzfeldt-Jakob Disease* (2003) (43)
- Fluctuations and averaging of proton chemical shifts in the bovine pancreatic trypsin inhibitor. (1982) (42)
- Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00215g Click here for additional data file. (2017) (42)
- A photochemically induced dynamic nuclear polarization study of denatured states of lysozyme. (1991) (42)
- Spin echo double resonance: a novel method for detecting decoupling in Fourier transform nuclear magnetic resonance (1975) (42)
- Bifunctional Anti-Non-Amyloid Component α-Synuclein Nanobodies Are Protective In Situ (2016) (42)
- Comparison of the denaturant-induced unfolding of the bovine and human alpha-lactalbumin molten globules. (2001) (42)
- Temperature-Dependent Solid-State 119Sn- MAS NMR of Nd2Sn2O7, Sm2Sn2O7, and Y1.8Sm0.2Sn2O7. Three Sensitive Chemical-Shift Thermometers (1993) (41)
- Individual aggregates of amyloid beta induce temporary calcium influx through the cell membrane of neuronal cells (2016) (41)
- Quantitative thermophoretic study of disease-related protein aggregates (2016) (41)
- Rationalising lysozyme amyloidosis: insights from the structure and solution dynamics of T70N lysozyme. (2005) (41)
- Correlation of proton chemical shifts in proteins using two-dimensional double-quantum spectroscopy (1983) (41)
- Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms (2016) (41)
- Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms (2013) (41)
- Rational design of a conformation-specific antibody for the quantification of Aβ oligomers (2020) (41)
- TWO-DIMENSIONAL 15N-1H PHOTO-CIDNP AS A SURFACE PROBE OF NATIVE AND PARTIALLY STRUCTURED PROTEINS (1999) (40)
- Structure and dynamics of a partially folded protein are decoupled from its mechanism of aggregation. (2008) (40)
- Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry (2015) (40)
- Paramagnetic shift probes in high-resolution solid-state NMR (1987) (40)
- Single-Molecule Imaging Reveals that Small Amyloid-β1–42 Oligomers Interact with the Cellular Prion Protein (PrPC) (2014) (39)
- Investigating the Mechanisms of Amylolysis of Starch Granules by Solution-State NMR (2015) (39)
- C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH† †Electronic supplementary information (ESI) available: Supplementary methods, supplementary results, supplementary tables, supplementary figures. See DOI: 10.1039/c8sc01109e (2018) (39)
- Internal motion of proteins: nuclear magnetic resonance measurements and dynamic simulations. (1986) (39)
- Cavity hydration as a gateway to unfolding: an NMR study of hen lysozyme at high pressure and low temperature. (2011) (39)
- Hydration of tricalcium silicate followed by solid-state 29Si n.m.r. spectroscopy (1984) (38)
- Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers (2020) (38)
- An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils (2019) (38)
- Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions. (2018) (38)
- Comparison of four independently determined structures of human recombinant interleukin–4 (1994) (37)
- Side-chain conformational disorder in a molten globule: molecular dynamics simulations of the A-state of human alpha-lactalbumin. (1999) (37)
- Analysis of the interactions between streptokinase domains and human plasminogen (1998) (37)
- Lysozyme: a major secretory product of a human colon carcinoma cell line. (1985) (37)
- A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation. (2013) (37)
- Proton NMR studies of denatured lysozyme (1984) (36)
- The carbonation of OPC and OPC/silica fume hardened cement pastes in air under conditions of fixed humidity (1993) (36)
- Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters. (2014) (36)
- Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2 (2018) (36)
- Separation of contact and pseudo-contact contributions to shifts induced by lanthanide(III) ions in nuclear magnetic resonance spectra (1973) (36)
- Insight into a random coil conformation and an isolated helix: structural and dynamical characterisation of the C-helix peptide from hen lysozyme. (1996) (36)
- Rapid distinction of intracellular and extracellular proteins using NMR diffusion measurements. (2012) (36)
- Role of elongation and secondary pathways in S6 amyloid fibril growth. (2012) (35)
- Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells (2018) (35)
- Thermodynamics and kinetics of folding of common-type acylphosphatase: comparison to the highly homologous muscle isoenzyme. (1999) (35)
- Exchange of individual hydrogens for a protein in a crystal and in solution. (1983) (35)
- Probing small molecule binding to amyloid fibrils. (2011) (35)
- Cooperative Elements in Protein Folding Monitored by Electrospray Ionization Mass Spectrometry (1995) (35)
- Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates (2017) (35)
- Determination of the structures of distinct transition state ensembles for a β-sheet peptide with parallel folding pathways (2002) (35)
- The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State (2020) (35)
- Selective removal of magnetization in coupled NMR spectra (1981) (35)
- High-resolution nitrogen-15 nuclear magnetic resonance studies of alpha-lytic protease in solid state. Direct comparison of enzyme structure in solution and in the solid state. (1984) (35)
- Conformation of GroEL-bound alpha-lactalbumin probed by mass spectrometry. (1994) (35)
- Proton NMR studies of the association and folding of glucagon in solution (1980) (34)
- Quantifying Co-Oligomer Formation by α-Synuclein (2018) (34)
- A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins. (2016) (34)
- Solution structure of the kringle domain from urokinase-type plasminogen activator. (1994) (34)
- Correlation of hydrogen exchange behaviour and thermal stability of lysozyme. (1983) (34)
- Structure and binding properties of hen lysozyme modified at tryptophan 62. (1981) (34)
- Characterization of the interdomain motions in hen lysozyme using residual dipolar couplings as replica-averaged structural restraints in molecular dynamics simulations. (2013) (34)
- Probing the exposure of tyrosine and tryptophan residues in partially folded proteins and folding intermediates by CIDNP pulse-labeling. (2002) (34)
- The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils. (2020) (33)
- Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation. (2018) (33)
- The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster. (2011) (33)
- A compact monomeric intermediate identified by NMR in the denaturation of dimeric triose phosphate isomerase. (2000) (33)
- Calculation of mutational free energy changes in transition states for protein folding. (2003) (33)
- Biophysical studies of the development of amyloid fibrils from a peptide fragment of cold shock protein B. (2000) (32)
- Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease (2011) (32)
- Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism (2020) (32)
- Characterization of the structure and dynamics of amyloidogenic variants of human lysozyme by NMR spectroscopy (2001) (32)
- Long-range correlations between aliphatic 13C nuclei in protein MAS NMR spectroscopy. (2009) (31)
- A Ca2+-binding Chimera of Human Lysozyme and Bovine α-Lactalbumin That Can Form a Molten Globule (*) (1995) (31)
- Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2 (2013) (31)
- Improved photo-CIDNP methods for studying protein structure and folding (2000) (31)
- Optical Structural Analysis of Individual α‐Synuclein Oligomers (2018) (30)
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- Structure of a low-population intermediate state in the release of an enzyme product (2015) (30)
- Relationship between Prion Propensity and the Rates of Individual Molecular Steps of Fibril Assembly* (2011) (30)
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- Hamiltonian Dynamics of Protein Filament Formation. (2016) (30)
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- The toxicity of misfolded protein oligomers is independent of their secondary structure. (2019) (29)
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- Reversible independent unfolding of the domains of urokinase monitored by 1H NMR. (1989) (28)
- Rapid formation of non-native contacts during the folding of HPr revealed by real-time photo-CIDNP NMR and stopped-flow fluorescence experiments. (2003) (28)
- 1H, 13C and 15N assignments of a camelid nanobody directed against human α-synuclein (2009) (28)
- A peptide model for proline isomerism in the unfolded state of staphylococcal nuclease. (1992) (28)
- Accurate determination of interstrand distances and alignment in amyloid fibrils by magic angle spinning NMR. (2010) (28)
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- A Study of Tricalcium Silicate Hydration from Very Early to Very Late Stages (1986) (27)
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- Structure of a Single-Chain Fv Bound to the 17 N-Terminal Residues of Huntingtin Provides Insights into Pathogenic Amyloid Formation and Suppression (2015) (26)
- Characterizing intermolecular interactions that initiate native-like protein aggregation. (2012) (26)
- A partially unfolded structure of the alkaline-denatured state of pepsin and its implication for stability of the zymogen-derived protein. (2000) (26)
- Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies (2019) (26)
- Analysis of the solution structure of human interleukin-4 determined by heteronuclear three-dimensional nuclear magnetic resonance techniques. (1994) (26)
- Complete assignment of the 1H NMR spectrum of the aromatic residues of lysozyme. (2005) (26)
- Molecular dynamics simulations of human α‐lactalbumin: Changes to the structural and dynamical properties of the protein at low pH (1999) (26)
- A magic angle spinning NMR study of the phase diagram Ca3−xZnx(PO4)2 (1989) (26)
- Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation (2020) (26)
- Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils (2019) (25)
- Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers (2021) (25)
- Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit. (2017) (25)
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- Hinge-bending and folding (1990) (25)
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- Ethylenediaminetetra-acetato-lanthanate(III), -praesodimate(III), -europate(III), and -gadolinate(III) complexes as nuclear magnetic resonance probes of the molecular conformations of adenosine 5′- monophosphate and cytidine 5′-monophosphate in solution (1974) (25)
- 1H, 15N and 13C assignments of domain 5 of Dictyostelium discoideum gelation factor (ABP-120) in its native and 8M urea-denatured states (2009) (25)
- Structural biology. Dynamic visions of enzymatic reactions. (2006) (24)
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- Characterization of collapsed states in the early stages of the refolding of hen lysozyme. (1998) (24)
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- The application of 29Si and 27Al solid state n.m.r. spectroscopy to characterising minerals in coals (1986) (24)
- Characterisation of Disulfide‐Bond Dynamics in Non‐Native States of Lysozyme and Its Disulfide Deletion Mutants by NMR (2005) (24)
- The study of conformational states of proteins by nuclear magnetic resonance. (1985) (24)
- Folding of small proteins by Monte Carlo simulations with chemical shift restraints without the use of molecular fragment replacement or structural homology. (2009) (24)
- Selective association of protein molecules followed by mass spectrometry (1999) (24)
- Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins (2021) (23)
- A rationally designed six-residue swap generates comparability in the aggregation behavior of α-synuclein and β-synuclein. (2012) (23)
- Dipolar NMR relaxation of nonprotonated aromatic carbons in proteins. Structural and dynamical effects. (1982) (23)
- Protein chemistry. In the footsteps of alchemists. (2004) (23)
- Nuclear-magnetic-resonance studies of 5'-ribonucleotide and 5'-deoxyribonucleotide conformations in solution using the lanthanide probe method. (1978) (23)
- Antigen mobility in the combining site of an anti-peptide antibody. (1991) (23)
- Solution structure of a peptide fragment of human alpha-lactalbumin in trifluoroethanol: a model for local structure in the molten globule. (1994) (23)
- A partially folded intermediate species of the β‐sheet protein apo‐pseudoazurin is trapped during proline‐limited folding (2001) (23)
- Contribution of rotational diffusion to pulsed field gradient diffusion measurements. (2007) (22)
- The Cytochrome c Fold Can Be Attained from a Compact Apo State by Occupancy of a Nascent Heme Binding Site* (2001) (22)
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- A solid-state 13C nuclear magnetic resonance study of the conformational states of penicillins (1986) (22)
- Conformational analysis of tryptophan in solution using nuclear magnetic resonance methods (1981) (22)
- The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends (2020) (22)
- Folding Study of Venus Reveals a Strong Ion Dependence of Its Yellow Fluorescence under Mildly Acidic Conditions* (2009) (22)
- Conformational studies on muscular parvalbumins cooperative binding of calcium (II) to parvalbumins. (1979) (22)
- NMR studies of the dynamics of the multidomain protein urokinase-type plasminogen activator. (1993) (22)
- Immunization with α‐synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model (2018) (22)
- Inhibiting the Ca2+ Influx Induced by Human CSF (2017) (22)
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- A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles (2020) (21)
- Spatial propagation of protein polymerization. (2014) (21)
- Gradient-free determination of isoelectric points of proteins on chip. (2017) (21)
- A conformational isomer of bovine pancreatic trypsin inhibitor protein produced by refolding (1980) (21)
- Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans. (2019) (21)
- Development of Enzymatic Activity during Protein Folding (1999) (21)
- Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster (2012) (21)
- Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors (2021) (20)
- Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter (2020) (20)
- Quantitative measurement using pure-phase two-dimensional exchange spectroscopy (1985) (20)
- Distance dependence of proton nuclear overhauser effects in proteins (1984) (20)
- Identification of glycine spin systems in 1H NMR spectra of proteins using multiple quantum coherences (1985) (20)
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- The length distribution of frangible biofilaments. (2015) (20)
- The importance of loop length in the folding of an immunoglobulin domain. (2004) (20)
- Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential. (2006) (20)
- Resting places on folding pathways (1992) (20)
- Phosphorus-31 magic angle spinning NMR study of the cation distribution in Zn3-xMgx(PO4)2 (1985) (19)
- Studies of Rare-Earth Stannates by 119Sn MAS NMR. The Use of Paramagnetic Shift Probes in the Solid State. (1989) (19)
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- Identification of residues involved in the interaction of Staphylococcus aureus fibronectin-binding protein with the (4)F1(5)F1 module pair of human fibronectin using heteronuclear NMR spectroscopy. (2000) (19)
- Identification using 1H NMR spectroscopy of slowly exchanging amide hydrogens of hen lysozyme in solution. (1984) (19)
- 1H, 15N and 13C assignments of yellow fluorescent protein (YFP) Venus (2009) (19)
- Ferrocene molecular reorientation in the (thiourea)3.cntdot.ferrocene inclusion compound as studied by deuteron NMR spectroscopy (1991) (19)
- Electrostatic origin of in vitro aggregation of human γ-crystallin. (2013) (19)
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- Folding and Fibril Formation of the Cell Cycle Protein Cks1* (2006) (18)
- The Generic Nature of Protein Folding and Misfolding (2006) (18)
- Characterization of structural and folding properties of streptokinase by n.m.r. spectroscopy. (1993) (18)
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- Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates (2015) (18)
- High resolution 13C MAS NMR spectra of paramagnetic lanthanide complexes (1990) (18)
- Crossing the boundary (2004) (18)
- A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis. (2010) (18)
- Solid State NMR and X-ray Diffraction Studies of Structure and Molecular Motion in ansa-Titanocenes (1995) (18)
- Amyloid-like Fibrils from an α-Helical Transmembrane Protein (2017) (18)
- Structural differences between toxic and nontoxic HypF-N oligomers. (2018) (18)
- Complete assignment of aromatic 1H nuclear magnetic resonances of the tyrosine residues of hen lysozyme. (1978) (18)
- The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme (2016) (17)
- Particle-Based Monte-Carlo Simulations of Steady-State Mass Transport at Intermediate Péclet Numbers (2016) (17)
- Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies (2015) (17)
- Binding of the molecular chaperone alphaB-crystallin to Abeta amyloid fibrils inhibits fibril elongation (2020) (17)
- Apomyoglobin reveals a random-nucleation mechanism in amyloid protofibril formation. (2006) (17)
- Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease (2019) (17)
- A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers (2021) (17)
- The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis (2017) (17)
- Correction for Perni et al., A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity (2017) (17)
- Local and Global Cooperativity in the Human α-Lactalbumin Molten Globule (2004) (17)
- Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein. (2016) (17)
- Lanthanoid(III) cations as nuclear magnetic resonance conformational probes: studies on cytidine 5′-monophosphate at pH 2 (1974) (17)
- Combination of cross polarization/magic angle spinning NMR and x-ray crystallography: structure and dynamics in a low-symmetry molecular crystal, potassium penicillin V (1993) (17)
- 1H and 15N Hyperfine Shifts of Cytochrome c (1999) (17)
- The Kinetics and Mechanisms of Amyloid Formation (2013) (16)
- Microfluidic approaches for probing amyloid assembly and behaviour. (2018) (16)
- Absolute Quantification of Amyloid Propagons by Digital Microfluidics (2017) (16)
- Measuring the kinetics of amyloid fibril elongation using quartz crystal microbalances. (2012) (16)
- Characterization of a trifluoroethanol-induced partially folded state of alpha-lactalbumin. (1994) (16)
- Nanobodies as structural probes of protein misfolding and fibril formation. (2012) (16)
- Calculation of the free energy barriers in the oligomerisation of Abeta peptide fragments. (2008) (16)
- Organometallic helicopters: stereochemical nonrigidity of .mu.3-arene/olefin triosmium complexes in solution and the solid state (1992) (16)
- Amyloidogenicity and aggregate cytotoxicity of human glucagon-like peptide-1 (hGLP-1). (2009) (16)
- Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles (2017) (15)
- Surface accessibility of aromatic residues in human lysozyme using photochemically induced dynamic nuclear polarization NMR spectroscopy (1985) (15)
- 1H, 15N and 13C assignments of the dimeric ribosome binding domain of trigger factor from Escherichia coli (2009) (15)
- Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions. (2018) (15)
- A general reaction network unifies the aggregation behaviour of the A$\beta$42 peptide and its variants (2016) (15)
- Equilibrium unfolding studies of horse muscle acylphosphatase. (1994) (15)
- Normal and Aberrant Biological Self-Assembly: Insights from Studies of Human Lysozyme and Its Amyloidogenic Variants (2006) (15)
- Analysis of sub-tauc and supra-tauc motions in protein Gbeta1 using molecular dynamics simulations. (2009) (15)
- Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming (2018) (15)
- Native-like secondary structure in a peptide from the α-domain of hen lysozyme (1996) (15)
- Studies of gold cluster compounds using high-resolution 31P solid-state nuclear magnetic resonance spectroscopy (1985) (15)
- Scaling analysis reveals the mechanism and rates of prion replication in vivo (2021) (15)
- Hydration of tricalcium silicate with D2O (1988) (15)
- 1H, 13C and 15N resonance assignments of human muscle acylphosphatase (2012) (14)
- Nuclear magnetic resonance studies of blood platelets. (1980) (14)
- Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification (2019) (14)
- Structural biology: Protein self-assembly intermediates. (2013) (14)
- sup 13 C CP/MAS NMR studies of the stereochemical nonrigidity of titanium tetracyclopentadienyl in the solid state (1991) (14)
- Combination of CP/MAS NMR Spectroscopy and X-ray Crystallography: Structure and Dynamics in Molecular Crystals of Hydrogen, Lithium, Sodium, Rubidium, and Cesium Penicillin V (1997) (14)
- Determination of the transition state ensemble for the folding of ubiquitin from a combination of Phi and Psi analyses. (2008) (14)
- Kinetic analysis of the stereochemical nonrigidity of the triosmium .mu.3-arene/alkene complex Os3(CO)8(.eta.2-CH2CH2)(.mu.3:.eta.2:.eta.2:.eta.2-C6H6) in the solid state by carbon-13 CP/MAS NMR spectroscopy (1991) (14)
- Unfolding studies of the protease domain of urokinase-type plasminogen activator: the existence of partly folded states and stable subdomains. (1994) (14)
- The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution. (2015) (14)
- Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform (2019) (14)
- Molecular characterisation of a thermoactive beta-1,3-glucanase from Oerskovia xanthineolytica. (1996) (13)
- 1H-NMR analysis of turkey egg-white lysozyme and comparison with hen egg-white lysozyme. (1993) (13)
- Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42. (2019) (13)
- Microfluidic Antibody Affinity Profiling for In-Solution Characterisation of Alloantibody - HLA Interactions in Human Serum (2020) (13)
- Conformations and conformational dynamics of proteins in solution studied by nuclear magnetic double resonance. (1980) (13)
- Influence of specific HSP 70 domains on fibril formation of the yeast prion protein Ure 2 (2013) (13)
- Physical and chemical properties of lysozyme. (1977) (13)
- Isotope-labeling strategy for the assignment of protein fragments generated for mass spectrometry (1996) (13)
- 2H NMR studies of metallocenes in host lattices (1987) (13)
- Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform (2016) (13)
- Sequential Release of Proteins from Structured Multishell Microcapsules. (2017) (13)
- Multiple subsets of side-chain packing in partially folded states of alpha-lactalbumins. (2005) (13)
- Characterization of single-tryptophan mutants of histidine-containing phosphocarrier protein: evidence for local rearrangements during folding from high concentrations of denaturant. (2003) (12)
- Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies (2014) (12)
- ThX – a next-generation probe for the early detection of amyloid aggregates† (2020) (12)
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- ThX – A next-generation probe for the early detection of amyloid aggregates (2019) (12)
- Mutational analysis of the aggregation-prone and disaggregation-prone regions of acylphosphatase. (2009) (12)
- Molecular dynamics simulations of peptide fragments from hen lysozyme: insight into non-native protein conformations. (1998) (12)
- Erratum: Widespread Proteome Remodeling and Aggregation in Aging C. elegans (Cell (2015) 161(4) (919–932) (S0092867415003207)(10.1016/j.cell.2015.03.032) (2017) (12)
- THE STRUCTURE OF A CHOLESTEROL: SHIFT REAGENT COMPLEX IN SOLUTION (1973) (12)
- Alzheimer’s disease: addressing a twenty-first century plague (2015) (12)
- Domain interactions in human plasminogen studied by proton NMR (1991) (12)
- Analysis of structural order in amyloid fibrils (2007) (11)
- Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species (2018) (11)
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- Conformational Effects of the A21G Flemish Mutation on the Aggregation of Amyloid β Peptide. (2015) (11)
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- Characterizing the first steps of amyloid formation for the ccbeta peptide. (2008) (11)
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- Sequential 1H NMR assignments and secondary structure of the kringle domain from urokinase. (1992) (11)
- Characterization of folding the four-helix bundle protein Rop by real-time NMR. (2008) (11)
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- Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers (2020) (11)
- The Amyloid Phenomenon and Its Significance (2013) (10)
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- Direct Conversion of an Enzyme from Native-like to Amyloid-like Aggregates within Inclusion Bodies. (2017) (10)
- Conservation of mechanism, variation of rate: folding kinetics of three homologous four-helix bundle proteins. (2008) (10)
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- The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel β-sheet α-synuclein aggregates† †Electronic supplementary information (ESI) available. See DOI: 10.1039/d0sc05297c (2020) (9)
- Efficient incorporation of deuterated amino acids into quail egg white proteins for nuclear magnetic resonance studies. (1981) (9)
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- Aromatic ring dynamics in crystalline penicillins from variable temperature 13C cross-polarisation magic-angle-spinning n.m.r. (1988) (8)
- Carbon-13 CP/MAS NMR study of the inclusion polymerization of 2,3-dimethylbutadiene in deoxycholic acid (1992) (8)
- A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease (2020) (8)
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- An Overview of Protein Misfolding Diseases (2008) (8)
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- Cooperative Assembly of Hsp70 Subdomain Clusters (2018) (7)
- A variable‐temperature 13C cross‐polarization magic angle spinning NMR study of some unusual dynamic and phase properties of (±)‐3,4‐di‐O‐acetyl‐1,2,5,6‐tetra‐O‐benzyl‐myo‐inositol, ‘jumping crystals’ (1992) (7)
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- Nuclear Magnetic Resonance Studies of the Interaction of Lanthanide Cations with Lysozyme (1977) (6)
- Protein Folding and Misfolding: From Atoms to Organisms (2008) (6)
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- Dynamics and timekeeping in biological systems. (2014) (6)
- Fast fluorescence lifetime imaging reveals the aggregation processes of α-synuclein and polyglutamine in aging Caenorhabditis elegans (2018) (5)
- Dynamics and Control of Peptide Self-Assembly and Aggregation. (2019) (5)
- Use of two-dimensional 1H nuclear magnetic resonance to study high-affinity antibody-peptide interactions. (1991) (5)
- Determination of the structural ensemble of the molten globule state of a protein by computer simulations (2019) (5)
- Selective substitution of 2H and 3H into aromatic amino acids catalyzed by Raney nickel (1979) (5)
- Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans (2021) (5)
- Native-like secondary structure in a peptide from the alpha-domain of hen lysozyme. (1996) (5)
- Functionalised fibrils for bio-nanotechnology (2006) (5)
- Imaging amyloid fibrils within cells using a Se-labelling strategy. (2009) (5)
- TRANSMEMBRANE DYNAMICS OF LIPIDS (2013) (5)
- Folding and binding: The biological consequences of physical principles (1999) (5)
- NMR spectroscopy and protein folding: studies of lysozyme and alpha-lactalbumin. (1991) (5)
- Folding and binding Emerging themes in protein folding and assembly (2001) (5)
- Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease (2018) (4)
- 29Si Enrichment and Selective Enrichment for Study of the Hydration of Model Cements and Blended Cements (1998) (4)
- Studies on enzymatic activity and conformational stability of muscle acylphosphatase mutated at conserved lysine residues. (1998) (4)
- Structural and functional stability of horseradish peroxidase. (1995) (4)
- Probing the unfolded protein response in long-lived naked mole-rats (2020) (4)
- Supporting information for: Quantifying Co-Oligomer Formation by Alpha-Synuclein (2018) (4)
- N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates (2022) (4)
- Hereditary systemic amyloidosis associated with mutational variants of human lysozyme (2005) (4)
- In Vivo Translation Rates Can Substantially Delay the Co-Translational Folding of the E. Coli Cytosolic Proteome (2013) (4)
- Kinetic fingerprints differentiate anti-Aβ therapies (2019) (4)
- Observation of discrete thiazolidine ring conformations in frozen aqueous solutions of penicillins by 13C CP–MAS NMR spectroscopy (1991) (4)
- A 31P MAS NMR study of cytidine 2′‐phosphate bound to ribonuclease A in the crystalline state (1987) (4)
- Mössbauer spectra of passivated iron surfaces (1973) (4)
- Protein Misfolding and Human Disease (2002) (4)
- The Amyloid Fibril-Forming β-Sheet Regions of Amyloid β and α-Synuclein Preferentially Interact with the Molecular Chaperone 14-3-3ζ (2021) (4)
- The Identification of Amino Acids by Interpretation of Titration Curves: An Undergraduate Experiment for Biochemistry (2014) (3)
- Nuclear magnetic shift and relaxation effects resulting from complexation of lanthanide ions with endo-cis-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid (1981) (3)
- Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis (2019) (3)
- NMR Studies of Protein Dynamics (1982) (3)
- Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response (2021) (3)
- Initial denaturing conditions influence the slow folding phase of acylphosphatase associated with proline isomerization (2000) (3)
- Probing protein aggregation with quartz crystal microbalances. (2011) (3)
- Substitutionally Enhanced STEM (SE-STEM) Imaging of Protein Aggregates Inside Cells (2011) (3)
- An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation (2016) (3)
- Parallel and Sequential Pathways of Molecular Recognition of a Tandem-Repeat Protein and Its Intrinsically Disordered Binding Partner (2021) (3)
- Binding of a substrate analogue can induce co-operative structure in the plasmin serine-proteinase domain. (1993) (3)
- Local and global cooperativity in the human alpha-lactalbumin molten globule. (2004) (3)
- The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity (2022) (3)
- Solution-state nuclear magnetic resonance spectroscopy and protein folding. (2011) (3)
- Comments on the proposed rigidity of staphylococcal protease. (1975) (2)
- Lysozyme Hydrolysis of β-Glycosides: A Consensus Between Binding Interactions and Mechanism (1990) (2)
- Human lysozyme amyloidosis (2007) (2)
- Thermodynamic and kinetic design principles for protein aggregation inhibitors (2020) (2)
- Expression and characterization of the intact N‐terminal domain of streptokinase (2008) (2)
- Identification of the epitopes of calcitonin gene‐related peptide (CGRP) for two anti‐CGRP monoclonal antibodies by 2D NMR (1997) (2)
- Synthesis, characterisation, and catalytic activity of a phosphinidene stabilised tethered triruthenium cluster (1988) (2)
- The role of structural dynamics in the thermal adaptation of hyperthermophilic enzymes (2022) (2)
- The solution dynamics of amyloidogenic Asp67His variant of human lysozyme: Insights from hydrogen exchange (2000) (2)
- Silicon-29 magic-angle-spinning nuclear magnetic resonance study of the crystalline–amorphous transition of zeolite A containing trapped krypton (1985) (2)
- Characterisation of the structural, dynamic and aggregation properties of the W64R amyloidogenic variant of human lysozyme. (2021) (2)
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences: 356 (1406) (2001) (2)
- Early Nascent Chain Folding Events on the Ribosome (2010) (2)
- Proton NMR Studies of Protein Dynamics and Folding: Applications of Magnetization Transfer NMR (1986) (2)
- Thermodynamics and kinetics of folding of common type acylphosphatase (1999) (2)
- Structural Characterization of Covalently Stabilized Human Cystatin C Oligomers (2019) (2)
- Solid state 31P cross-polarization/magic angle sample spinning nuclear magnetic resonance of crystalline glycogen phosphorylase b. (1993) (2)
- TWO-DIMENSIONAL EXCHANGE EXPERIMENTS IN NMR STUDIES OF PROTEIN DYNAMICS AND FOLDING (1987) (2)
- Long-Range Correlations between Aliphatic13C Nuclei in Protein MAS NMR Spectroscopy (2009) (2)
- Frontiers in Computational Biophysics: A Symposium in Honor of Martin Karplus (2005) (2)
- Protein folding, misfolding and disease (2000) (2)
- Correction: Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice. (2020) (2)
- 1H, 13C and 15N resonance assignments of human muscle acylphosphatase (2011) (2)
- Protein structure . Trapping folding intermediates. (1988) (2)
- Rapid Fractionation and Characterisation of Alpha-Synuclein Oligomers in Solution (2020) (2)
- Single-Molecule Characterisation of Alpha-Synuclein Oligomers (2014) (2)
- Plagues and History: From the Black Death to Alzheimer's Disease (2017) (2)
- Conformational Fluctuations of Hen Lysozyme Investigated by High Pressure NMR Spectroscopy (2003) (1)
- The N-terminus of amyloid-beta plays a crucial role in its aggregation and toxicity (2010) (1)
- Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson’s disease model (2018) (1)
- Inhibiting the Ca 2 + Influx In duced by Human CSF Graphical (2017) (1)
- Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies (2014) (1)
- Quantifying the Thermodynamic Stability of Amyloid Fibrils (2020) (1)
- 19 – New nmr Techniques for the Quantitative Determination of the Structure of Proteins in Solution Applied to Hen Egg-White Lysozyme (HEWL) (1974) (1)
- Molecular conformation of a peptide in an amyloid fibril (2003) (1)
- Correction to ‘Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species’ (2018) (1)
- Camelid single-domain antibody fragments as structural probes to study the mechanism of human lysozyme fibrils formation (2010) (1)
- ALTERED AGGREGATION PROPERTIES OF M-CRYSTALLINS CAUSE INHERITED CATARACT (2002) (1)
- INTO THE LINK BETWEEN AGGREGATION AND NEUROTOXICITY (2012) (1)
- 31P Magic Angle Spinning NMR Study of the Cation Distribution in Zn3-xMgx(PO4)2. (1986) (1)
- Response: Amyloidosis and Protein Folding (2005) (1)
- Structures and Energetics of Proteins and their Active Sites (2007) (1)
- NMR solution structure of hen lysozyme (2000) (1)
- Machine learning aided top-down proteomics on a microfluidic platform (2020) (1)
- Imaging Alzheimer's disease-related protein aggregates in human cells using a selenium label (2010) (1)
- The formation of amyloid fibrils by relaxin (2001) (1)
- Information for : “ A causative link between the structure of aberrant protein oligomers and their ability to cause cellular dysfunction (2009) (1)
- Measurement of Magnetic Detachment Effects in a Magnetic Nozzle (2007) (1)
- Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates (2018) (1)
- ATOMIC-RESOLUTION STRUCTURE OF A CROSS-BETA QUADRUPLET AMYLOID FIBRIL DETERMINED BY SOLID-STATE MAGIC ANGLE SPINNING NMR AND CRYO-EM (2013) (1)
- SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation (2015) (1)
- Machine learning-aided protein identification from multidimensional signatures† (2021) (1)
- Protein Misfolding Diseases and the Key Role Played by the Interactions of Polypeptides with Water (2009) (1)
- Production of15N-labelled hen egg white lysozyme usingAspergillus niger (1992) (1)
- Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity (2018) (1)
- Protein folding - Preface (1995) (1)
- Proteome Metastability in Health, Aging, and Disease (2014) (1)
- From Computer Simulations Meeting Review to Human Disease: Emerging Themes in Protein Folding (1999) (1)
- Analysis of Sub-tc and Supra-tc Motions in Protein Gb1 Using Molecular Dynamics Simulations (2009) (1)
- Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species (2017) (1)
- A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers (2021) (1)
- Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases – ERRATUM (2020) (1)
- Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species (2017) (1)
- Determination of Primary Nucleation Mechanisms of α-Synuclein Amyloid Aggregation (2014) (1)
- Probing protein folding on the Ribosome by Solution State NMR Spectroscopy (2009) (1)
- Author response: Structure of a low-population intermediate state in the release of an enzyme product (2014) (1)
- Monitoring Protein Folding Using Time-Resolved Biophysical Techniques (1998) (1)
- Mapping the structural characteristics of an ion channel in lipid bilayers: A H/D exchange MS/MS study of gramicidin A. (1999) (1)
- Protein Misfolding Diseases (2019) (1)
- On the Effect of the Ribosome and Trigger Factor on Nascent Chain Protein Folding (2011) (0)
- Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles (2017) (0)
- The Royal Society of r and rate-determining steps in fi lamentous self-assembly † (2017) (0)
- Studies of Gold Cluster Compounds Using High-resolution31P Solid-state NMR Spectroscopy (Untersuchungen an (I)-(IV). (1986) (0)
- Structural Investigation of an SH3 Amyloid Protein Fibril (2009) (0)
- Complex of human lysozyme with camelid VHH HL6 antibody fragment (2003) (0)
- Solid state 3'P cross-polarization/magic angle sample spinning nuclear magnetic resonance studies of crystalline glycogen phosphorylase b (2005) (0)
- Studying Distribution and Aggregation of TDP-43 in Mammalian Cells: A Comparison between Fluorescent Protein and Tetracysteine Labelling Strategies (2014) (0)
- Site-specific Detection of Conformational Fluctuation by High Pressure NMR (2003) (0)
- Atomic-resolution structure of a quadruplet cross-beta amyloid fibril (2013) (0)
- A single-domain antibody fragment that stabilises the native state of two amyloidogenic lysozyme variants and hence prevents aggregation (2002) (0)
- Multistep Inhibition of a-synuclein aggregation and toxicity in vitro 1 and in vivo by trodusquemine 2 3 (2019) (0)
- Research data supporting "Physical determinants for the self-replication of protein fibrils" (2016) (0)
- Probing the Interaction Between α-Synuclein and Lipid Membranes by NMR Spectroscopy (2014) (0)
- 1H and 15N Chemical Shift Assignments for wild-type alpha-synuclein (2018) (0)
- Regulatory apparatus of Calcium Dependent protein kinase from Arabidopsis thaliana (2005) (0)
- NUCLEAR MAGNETIC SHIFT AND RELAXATION EFFECTS RESULTING FROM COMPLEXATION OF LANTHANIDE IONS WITH ENDO-CIS-BICYCLO(2.2.1)HEPT-5-ENE-2,3-DICARBOXYLIC ACID (1981) (0)
- Mutations in Gamma-Crystallins Lead to Amyloid Fibre Formation (2002) (0)
- Supplementary material from "Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species" (2018) (0)
- Insights into the Inhibition Mechanism of Biomolecular Self-Assembly from Chemical Kinetics (2014) (0)
- Structure of a single domain camelid antibody fragment in complex with a C-terminal peptide of alpha-synuclein (2010) (0)
- 1 Folding and fibril formation of the cell cycle protein Cks (2006) (0)
- Quantitative approaches for characterising fibrillar protein nanostructures (2010) (0)
- Urea denaturation promoted bovine beta-lactoglobulin fibrillogenesis (2001) (0)
- Structural Studies of Unfolded and Partly Folded Proteins Using NMR Spectroscopy (1988) (0)
- Amyloid-type fibrillation of the all alpha protein myoglobin (2000) (0)
- A metastable subproteome underlies inclusion formation in muscle proteinopathies (2019) (0)
- Correction. Protein Folding Kinetics from Magnetization Transfer Nuclear Magnetic Resonance (1984) (0)
- Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism (2020) (0)
- Conformational dynamics and protein unfolding in lysozyme amyloidosis (1999) (0)
- Disaggregation Experiments as a Tool to Detect Protofibrillar Intermediates (2004) (0)
- Fast Fluorescence Lifetime Imaging for Longitudinal Studies of Protein Aggregation in Living C. Elegans (2018) (0)
- Corrigendum (2016) (0)
- Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms (2019) (0)
- Targeting the Formation of Amyloid Oligomers using Rationally Designed Antibodies (2019) (0)
- Obituary: Nico van Nuland 1961–2017 (2018) (0)
- EBSA 2017 Satellite Meeting Biophysical Approaches to Protein Folding and Disease 20-21 July 2017 EICC Edinburgh ( UK ) (2017) (0)
- SYNTHETIC 17 AMINO ACID LONG PEPTIDE THAT FORMS A NATIVE-LIKE COILED-COIL AT AMBIENT TEMPERATURE AND AGGREGATES INTO AMYLOID-LIKE FIBRILS AT HIGHER TEMPERATURES. (2004) (0)
- Calmodulin complexed with calmodulin-binding peptide from smooth muscle myosin light chain kinase (2008) (0)
- NMR studies of turkey lysozyme (1990) (0)
- SEPARATION OF CONTACT AND PSEUDO-CONTACT CONTRIBUTIONS TO SHIFTS INDUCED BY LANTHANIDE(III)-IONS IN NUCLEAR MAGNETIC RESONANCE SPECTRA (1974) (0)
- Synthesis, Characterization, and Catalytic Activity of a Phosphinidine Stabilized Tethered Triruthenium Cluster. (1989) (0)
- ments of protein unfolding from direct observations of micron-scale di ff usion † (2018) (0)
- [Self-organization of protein structures--a bridge between physics and biology]. (1999) (0)
- Wales Andrew Wheatley Paul Wood Peter Wothers Dominic Wright An introduction to Cambridge Chemistry Academic staff (2012) (0)
- Developing NMR methods for macromolecular machines: Measurement of residual dipolar couplings to probe dynamic regions of the ribosome (2018) (0)
- ThX: a next generation probe for the early detection of amyloid aggregates (2022) (0)
- The Mechanism of Amyloid Formation and Its Links to Human Disease and Biological Evolution (2002) (0)
- Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response (2021) (0)
- Microfluidic antibody affinity profiling of alloantibody-HLA interactions in human serum. (2023) (0)
- To Begin with Excerpts from the reference:-Biochemistry 1982, 21, 11 18-1 125 Fluctuations and Averaging of Proton Chemical Shifts in the Bovine Pancreatic Trypsin Inhibitor? (2010) (0)
- PNAS Plus Significance Statements (2014) (0)
- Chaperones suppress the toxicity of aberrant protein aggregates. Molecular insight into the mechanism of action (2012) (0)
- Hsc70 mediated disaggregation of α-synuclein fibrils (2022) (0)
- "Life on the Edge": The Relationship Between Cell Abundances and Physical Properties of Proteins (2016) (0)
- NEURONAL BUNGAROTOXIN, NMR, 10 STRUCTURES (1998) (0)
- Single-Molecule Characte rization of the Interactions between Extracellular Chaperones and Toxic a-Synuclein Oligomers Graphical (2018) (0)
- Investigating the Factors Affecting the Aggregation of Alpha-Synuclein using Single Molecule Fluorescence and Fast Flow Microfluidics (2012) (0)
- Structural Studies of the Oligomerization Process of Human Cystatin C Variants (2016) (0)
- Protein folding and misfolding: from theory to therapy (2007) (0)
- Synthesis of Silyl Ether Linkers for Solid-Phase Peptide Synthesis (2006) (0)
- Publisher Correction: A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers (2021) (0)
- Erratum: Prediction of variable translation rate effects on cotranslational protein folding (2013) (0)
- Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes (2019) (0)
- Genes and Common Diseases: Diseases of protein misfolding (2007) (0)
- Scaling analysis reveals molecular mechanism of prion self-replication in vivo . (2021) (0)
- A Cell- and Tissue-Specific Weakness of the Protein Homeostasis System Underlies Brain Vulnerability to Protein Aggregation. (2020) (0)
- Microfluidic Diffusional Sizing for Studying Protein-Protein Interactions (2020) (0)
- Aggregation Diseases ndProteostasis to Ameliorate Protein Misfolding a Chemical and Biological Approaches for Adapting (2011) (0)
- Estimating alpha-beta coupling constants from NH-alphaCH crosspeak fine structure (1991) (0)
- A kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading Short title : Templated seeding of alpha-synuclein aggregation (2016) (0)
- A Solid‐State 13C NMR Study of the Conformational States of Penicillins (I) and (II). (1987) (0)
- LMW U-PA Structure complexed with EGRCMK (GLU-GLY-ARG Chloromethyl Ketone) (1996) (0)
- 1H and 15N Chemical Shift Assignmentsfor Recombinant Bovine Alpha-Lactalbumin (1999) (0)
- Mechanism of Non-Specific Inhibitors of Amyloid Assembly: Interactions of Lacmoid with the Amyloid Beta Peptide (2012) (0)
- Merging of the Classes: Structural Relationship between Two Distinct Protein Classes (2000) (0)
- Long-Range Correlations between Aliphatic [superscript 13]C Nucleic in Protein MAS NMR Spectroscopy (2009) (0)
- High-Resolution Solid-State 119Sn NMR Spectroscopy of Ternary Tin Oxides. (1989) (0)
- Human zone protein stabilises misfolded proteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide (2019) (0)
- An engineered monomer 1 binding-protein for-synuclein 2 efficiently inhibits the proliferation 3 of amyloid fibrils (2019) (0)
- Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation (2017) (0)
- Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling (2018) (0)
- Atomic-resolution structure of a cross-beta protofilament (2013) (0)
- CHARACTERISATION OF THE STRUCTURAL, DYNAMIC AND AGGREGATION PROPERTIES OF THE W64R AMYLOIDOGENIC MUTANT OF LYSOZYME (2016) (0)
- Self-assembly of a globular protein into native-like and enzymatically active aggregates that subsequently reorganize to form amyloid structures (2005) (0)
- Proteolytic fragmentation and H-NMR evdence for structurally independent domains in human uroiunase (1989) (0)
- Biophysical analysis of the insulin amyloid assembly process (2000) (0)
- The Physical Basis of the Amyloid Phenomenon (2017) (0)
- TARGETING AMYLOID FORMATION USING RATIONALLY DESIGNED ANTIBODIES (2018) (0)
- Cover Feature: Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells (ChemBioChem 19/2018) (2018) (0)
- Analysis of Sub- t c and Supra- t c Motions in Protein G 1 Using Molecular Dynamics Simulations (2009) (0)
- Comparison of solution and X-ray structures of proteins using coupling constants (1992) (0)
- NMR Studies of Protein Dynamics and Folding (1989) (0)
- Nanobodies as structural probes to investigate the mechanism of fibril formation by the amyloidogenic variants of human lysozyme (2011) (0)
- Thermodynamics and kinetics of protein folding on the ribosome: Alteration in energy landscapes, denatured state, and transition state ensembles (2010) (0)
- Site-Specific Hydration Dynamics Illuminates the Key Structural Features of Membrane-Bound -Synuclein (2014) (0)
- Atomic-resolution structure of a triplet cross-beta amyloid fibril (2013) (0)
- Structure-Free Validation of RDC and PRE Measurements of Disordered Proteins (2015) (0)
- 1 The Amyloid Phenomenon and Its Significance (2012) (0)
- Folding and fibril formation of the cell cycle protein Cks 1 Running (2006) (0)
- Book Review:Magnetic Resonance in Biology. Volume 1. Jack S. Cohen (1981) (0)
- Straightening the Hierarchical Staircase for Basis Set Extrapolations: A Low-Cost Approach to High-Accuracy Computational Chemistry (2020) (0)
- Abstract B35: Targeting the N-myc oncoprotein using nanobody technology (2015) (0)
- LANTHANOID(III) CATIONS AS NUCLEAR MAGNETIC RESONANCE CONFORMATIONAL PROBES, STUDIES ON CYSTIDINE 5′-MONOPHOSPHATE AT PH 2 (1974) (0)
- Molecular links between aberrant protein oligomers and neurodegeneration in Alzheimer’s disease (2015) (0)
- Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation (2020) (0)
- Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response (2021) (0)
- Insights into Protein Dynamics by NMR Techniques (1996) (0)
- Clusterin protects neurons against intracellular proteotoxicity (2017) (0)
- Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response (2021) (0)
- Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming (2019) (0)
- Characterization of the aggregation competent state of the acylphosphatase from Sulfolobus solfataricus (2010) (0)
- Applications of Magnetization Transfer NMR (1986) (0)
- STRUCTURE OF TRANSTHYRETIN IN AMYLOID FIBRILS DETERMINED BY SOLID-STATE MAGIC ANGLE SPINNING NMR (2004) (0)
- Elucidating the Structural Basis of α-Synuclein Fibrillation using Small Camelid Nanobodies (2014) (0)
- STRUCTURE OF T70N HUMAN LYSOZYME (2004) (0)
- Effects of Amyloid-Beta Expression on Neuronal Signalling Pathways in a Novel C. elegans Model of Alzheimer's Disease (2017) (0)
- Resonance assignments of the SH3 domain of phosphatidylinositol-3-kinase (PI3-SH3) in amyloid fibril form determined by MAS NMR spectroscopy (2009) (0)
- Amyloid growth: combining experiment and kinetic theory (2012) (0)
- Escalating protein supersaturation underlies inclusion formation in muscle proteinopathies (2019) (0)
- Diagnostics for In-space Testing of High Power Electric Thrusters on the International Space Station (2005) (0)
- The conformation of lysozyme in solution (1975) (0)
- Accelerating Reaction Rates of Biomolecules by Using Shear Stress in Artificial Capillary Systems. (2021) (0)
- Rapid refolding of a proline-rich all-, 8-sheet fibronectin type III module ( 10 th fibronectin type III domain protein folding kinetics ) (2005) (0)
- NMR Studies of Dynamics in Molecular Crystals (1990) (0)
- Prions and the lymphoreticular system - Discussion (2001) (0)
- Obituary: Nico van Nuland 1961–2017 (2018) (0)
- The Effects of Trifluoroethanol on the Folding Kinetics of Proteins (2000) (0)
- Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein (2017) (0)
- OVEREXPRESSION OF HSPB8 PROTECTS AGAINST TDP43-MEDIATED TOXICITY IN DROSOPHILA (2015) (0)
- April 10 " Life on the Edge : The Nature and Origins of Protein Misfolding Diseases " (2008) (0)
- PLATFORM F: Protein Dynamics - Experiment & Simulation (2011) (0)
- Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains (2022) (0)
- Influence of solvents on gramicidin a conformational interconversion (1998) (0)
- Folding and mis-folding of proteins (2013) (0)
- Chaperone molecules concentrate together with the ubiquitin-proteasome system inside particulate cytoplasmic structures : possible role in metabolism of misfolded proteins (2015) (0)
- Mechanisms of Amyloid-beta 42 oligomer formation from kinetic analysis (2017) (0)
- 1P079 Mechanism of amyloid formation by beta-lactoglobulin and its relationship with its folding process (2005) (0)
- Atomic-resolution structure of a doublet cross-beta amyloid fibril (2013) (0)
- The structure of the camelid antibody cAbHuL5 in complex with human lysozyme (2013) (0)
- ectrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the A b 42 peptide and its variants † (2017) (0)
- Backbone 1H, 13C, and 15N Chemical Shift Assignments for ribosomal protein bL12 S89C and with LBT tag (2019) (0)
- Measurements of electron density and energy content in the VX-30 helicon discharge (2005) (0)
- Detecting and Characterizing Amyloid-β1-40 Oligomers using Single Molecule Fluorescence (2010) (0)
- Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells (2018) (0)
- Publisher Correction: A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers (2021) (0)
- Microsoft Word-EXPRESSION IN DROSOPHILA OF TANDEM Aβ PEPTIDES PROVIDES INSIGHTS.docx (2012) (0)
- Optimization of the Production of the Amyloidogenic Variants of Human Lysozyme (2008) (0)
- Syddansk Universitet Amyloid-and-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox (2016) (0)
- Structural investigation of the folding of an immunoglobulin domain on the ribosome using NMR Spectroscopy (LB197) (2014) (0)
- The Mechanisms of Aberrant Protein Aggregation (2012) (0)
- Molecular Interactions of the Tick Salivary Protein Salp15 (2012) (0)
- Crystal structure of scFvC4 in complex with the first 17 AA of huntingtin (2015) (0)
- A Lysozyme Molecular Dynamics Simulation (1986) (0)
- Scaling exponents report on changes in the mechanism of filamentous growth (2012) (0)
- ETHYLENEDIAMINETETRA-ACETATO-LANTHANATE(III), -PRASEODIMATE(III), -EUROPATE(III), AND -GADOLINATE(III) COMPLEXES AS NUCLEAR MAGNETIC RESONANCE PROBES OF THE MOLECULAR CONFORMATIONS OF ADENOSINE 5′-MONOPHOSPHATE AND CYTIDINE 5′-MONOPHO (1974) (0)
- Are there common themes in the function, energy landscape, and dynamics of Proteins? (1999) (0)
- Protein Folding and Aggregation and its Relationship to Disease (2000) (0)
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