Robert L. Letsinger
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American chemist
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Chemistry
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(Suggest an Edit or Addition)According to Wikipedia, Robert Lewis Letsinger was an American biochemist and was a professor of chemistry at Northwestern University. He was best known for his research and development of chemical synthesis of DNA. Life Letsinger earned his B.S. in 1943 his Ph.D. in 1945, both at the Massachusetts Institute of Technology in Cambridge, Massachusetts. In 1946, he joined the department of chemistry at Northwestern University. He retired from teaching in 1991 as the emeritus Clare Hamilton Hall Professor.
Robert L. Letsinger's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A DNA-based method for rationally assembling nanoparticles into macroscopic materials (1996) (5257)
- Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles. (1997) (3596)
- Scanometric DNA array detection with nanoparticle probes. (2000) (2031)
- One-Pot Colorimetric Differentiation of Polynucleotides with Single Base Imperfections Using Gold Nanoparticle Probes (1998) (1840)
- A fluorescence-based method for determining the surface coverage and hybridization efficiency of thiol-capped oligonucleotides bound to gold thin films and nanoparticles. (2000) (881)
- Programmed Assembly of DNA Functionalized Quantum Dots (1999) (604)
- DNA-Directed Synthesis of Binary Nanoparticle Network Materials (1998) (545)
- Distance-dependent electron transfer in DNA hairpins. (1997) (396)
- Homogeneous, Nanoparticle-Based Quantitative Colorimetric Detection of Oligonucleotides (2000) (375)
- Dynamics of photoinduced charge transfer and hole transport in synthetic DNA hairpins. (2001) (363)
- Sequence-Dependent Stability of DNA-Modified Gold Nanoparticles (2002) (353)
- Multiple thiol-anchor capped DNA-gold nanoparticle conjugates. (2002) (318)
- Cholesteryl-conjugated oligonucleotides: synthesis, properties, and activity as inhibitors of replication of human immunodeficiency virus in cell culture. (1989) (240)
- The DNA-Mediated Formation of Supramolecular Mono- and Multilayered Nanoparticle Structures (2000) (214)
- Synthesis of thymidine oligonucleotides by phosphite triester intermediates. (1976) (214)
- Photochemical Reactions of Benzophenone in Alcohols1 (1959) (189)
- OLIGONUCLEOTIDE SYNTHESIS ON A POLYMER SUPPORT. (1965) (166)
- Use of a steroid cyclic disulfide anchor in constructing gold nanoparticle-oligonucleotide conjugates. (2000) (136)
- Directed Assembly of Periodic Materials from Protein and Oligonucleotide-Modified Nanoparticle Building Blocks. (2001) (133)
- Popcorn Polymer as a Support in Multistep Syntheses (1963) (122)
- The Electrical Properties of Gold Nanoparticle Assemblies Linked by DNA. (2000) (120)
- BISPYRENYL EXCIMER FLUORESCENCE : A SENSITIVE OLIGONUCLEOTIDE PROBE (1997) (116)
- Dynamics of Photoinduced Charge Separation and Charge Recombination in Synthetic DNA Hairpins with Stilbenedicarboxamide Linkers (2000) (106)
- Syringe method for stepwise chemical synthesis of oligonucleotides. (1982) (95)
- Reactions on Polymer Supports (1964) (95)
- Nucleotide chemistry. XIII. Synthesis of oligothymidylates via phosphotriester intermediates (1969) (94)
- Oxalyl-CPG: a labile support for synthesis of sensitive oligonucleotide derivatives. (1991) (89)
- Use of a Stilbenedicarboxamide Bridge in Stabilizing, Monitoring, and Photochemically Altering Folded Conformations of Oligonucleotides (1995) (85)
- Nucleotide chemistry. XX. Use of the azido group in the synthesis of 5'-terminal aminodeoxythymidine oligonucleotides (1975) (83)
- Unsymmetrical secondary phosphine oxides. Synthetic, isotopic exchange, and stereochemical studies (1968) (80)
- What Controls the Optical Properties of DNA-Linked Gold Nanoparticle Assemblies?* (2020) (76)
- Stepwise synthesis of oligodeoxyribonucleotides on an insoluble polymer support. (1966) (74)
- Structure and photoinduced electron transfer in exceptionally stable synthetic DNA hairpins with stilbenediether linkers (1999) (72)
- Convenient method for stepwise synthesis of oligothymidylate derivatives in large-scale quantities (1967) (72)
- Mode of action of 5'-linked cholesteryl phosphorothioate oligodeoxynucleotides in inhibiting syncytia formation and infection by HIV-1 and HIV-2 in vitro. (1991) (68)
- Hybrid Oligonucleotides Containing Stilbene Units. Excimer Fluorescence and Photodimerization (1995) (64)
- Synthesis and properties of oligonucleotides containing aminodeoxythymidine units (1992) (63)
- Organoboron Compounds. IV.1 Aminoethyl Diarylborinates (1955) (63)
- α- versus β-Elimination in the Cleavage of Ethers by Organoalkali Metal Compounds (1956) (63)
- A gold nanoparticle/latex microsphere-based colorimetric oligonucleotide detection method (2000) (61)
- A Covalent Lock for Self-Assembled Oligonucleotide Conjugates (1995) (59)
- Control of folding and binding of oligonucleotides by use of a nonnucleotide linker (1992) (56)
- FORMATION OF OPTICALLY ACTIVE 1-METHYLHEPTYLLITHIUM (1950) (52)
- Polymerization. XII. The Metalation of Olefins and Dienes and their Use in Alfin Polymerization of Butadiene1 (1950) (52)
- Selectivity in binding a phenanthridinium-dinucleotide derivative to homopolynucleotides (1981) (50)
- Chemical ligation of oligonucleotides in the presence and absence of a template (1993) (48)
- Synthesis of oligonucleotides via monomers with unprotected bases (1991) (48)
- Synthesis and characterization of DNA with ferrocenyl groups attached to their 5′-termini: electrochemical characterization of a redox-active nucleotide monolayer (1996) (46)
- Nucleotide chemistry. XX. Phosphite coupling procedure for generating internucleotide links (2002) (44)
- Nucleotide chemistry. XVI. Phosporamidate analogs of oligonucleotides (1970) (44)
- Organoboron Compounds. VIII. Dihydrobenzoboradiazoles1 (1958) (41)
- Some developments in the phosphitetriester method for synthesis of oligonucleotides (1984) (40)
- Use of p-nitrophenyl chloroformate in blocking hydroxyl groups in nucleosides. (1967) (40)
- Nucleotide chemistry. XV. Developments in syntheses of oligodeoxyribonucleotides and their organic derivatives (1969) (39)
- Selectivity in Solvolyses Catalyzed by Poly-(4-vinylpyridine) (1962) (39)
- Photoinduced Substitution. II. Substituent Effects in Nucleophilic Displacement on Substituted Nitrobenzenes1,2 (1965) (39)
- Enhancement of selectivity in recognition of nucleic acids via chemical autoligation. (1994) (38)
- Use of trichlorodimethylethyl as a protecting group and tributylphosphine as a deprotecting agent in oligonucleotide synthesis (1982) (38)
- Effects of pendant groups at phosphorus on binding properties of d-ApA analogues. (1986) (38)
- Organoboron Compounds. X.1,2 Popcorn Polymers and Highly Cross-linked Vinyl Polymers Containing Boron (1959) (38)
- Nucleotide chemistry. XIV. Protecting groups for nucleosides used in synthesizing oligonucleotides (1969) (37)
- Selective O-phosphitilation with nucleoside phosphoramidite reagents. (1992) (37)
- Use of isobutyloxycarbonyl as a blocking group in preparation of 3'-O-(p-methoxytrityl)thymidine (1967) (37)
- Organoboron Compounds. XVI. Coöperative Functional Group Effects in Reactions of Boronoarylbenzimidazoles (1963) (37)
- Synthesis of deoxyguanylyldeoxyguanosine on an insoluble polymer support. (1968) (36)
- Synthesis of Pyranones and Benzofluorenones from Ketones and Carboxylic Acids1 (1961) (35)
- Oligonucleotide syntheses utilizing beta-benzoylpropionyl, a blocking group with a trigger for selective cleavage. (1967) (34)
- Condensations by Sodium. XXX. The Metalation of Olefins and the Preparation of β,γ-Unsaturated Acids (1945) (34)
- Reactions of nucleosides on polymer supports. Synthesis of thymidylylthymidylylthymidine. (1967) (33)
- Control of excimer emission and photochemistry of stilbene units by oligonucleotide hybridization (1994) (33)
- Organoboron Compounds. VI.1 Preparation of a Heterocyclic Organoboron Compound (1955) (31)
- Template controlled coupling and recombination of oligonucleotide blocks containing thiophosphoryl groups. (1993) (30)
- Organoboron Compounds. XII. Heterocyclic Compounds from Benzeneboronic Acid1 (1960) (29)
- Stabilization of triple-stranded oligonucleotide complexes: use of probes containing alternating phosphodiester and stereo-uniform cationic phosphoramidate linkages. (1996) (28)
- Peri-Substituted Naphthalene Compounds. V.1,2 1,8-Dilithionaphthalene (1962) (28)
- Photoinduced substitution reactions. IX. Effects of micelles on the efficiency of photoinduced substitution reactions and fluorescence quenching (1971) (28)
- Use of hydrophobic substituents in controlling self-assembly of oligonucleotides (1993) (28)
- A new approach to synthesis of Oligonucleotides with 3′ phosphoryl groups (1992) (27)
- Investigation of a Synthetic Catalytic System Exhibiting Substrate Selectivity and Competitive Inhibition1,2 (1965) (26)
- Informational liposomes: Complexes derived from cholesteryl-conjugated oligonucleotides and liposomes (1996) (25)
- Organoboron Compounds. XIV.1,2 Polyfunctional Catalysis by 8-Quinolineboronic Acid (1963) (25)
- Distance-dependent photoinduced electron transfer in synthetic single-strand and hairpin DNA (1998) (25)
- Enzymatic synthesis of polydeoxyribonucleotides possessing internucleotide phosphoramidate bonds. (1972) (24)
- Organoboron Compounds. XI. Isomerization of 2,2'-Tolandiboronic Acid1 (1959) (23)
- The Preparation of Ethylidene Iodide (1951) (23)
- Selective chemical autoligation on a double-stranded DNA template. (1994) (22)
- Intramolecular Catalysis in Addition of Carboxyl to Carbon-Carbon Triple Bonds1 (1965) (22)
- Synthesis and spectroscopy of Ru(II)-bridged DNA hairpins (1999) (21)
- Hybridization of Alternating Cationic/Anionic Oligonucleotides to RNA Segments (1994) (21)
- Organoboron Compounds. XX. Chemistry of Some 1-Naphthaleneboronic Acids with Substituents in the 8-Position1 (1965) (21)
- Displacement Reactions Involving Optically Active Alkyl Bromides and Organometallic Compounds1 (1950) (21)
- Organoboron Compounds. V. The Preparation of an Unsymmetrical Diarylborinate (1955) (21)
- Organoboron Compounds. IX. 8-Quinolineboronic Acid, its Preparation and Influence on Reactions of Chlorohydrins1 (1959) (21)
- Notes - Reactions of Organometallic Compounds with Pyridazine (1956) (21)
- Synthesis of phosphoromonoamidate diester nucleotides via the phosphite-azide coupling method (1975) (21)
- Photoinduced Substitution. III. Replacement of Aromatic Hydrogen by Cyanide1,2 (1966) (20)
- Organoboron Compounds. XV.1 Stereochemistry of the Reaction of 8-Quinolineboronic Acid with Chloroalcohols (1963) (20)
- Oligonucleotides with alternating anionic and cationic phosphoramidate linkages: Synthesis and hybridization of stereo-uniform isomers (1996) (20)
- Polymerization. VI. The Alfin Catalysts1a (1947) (20)
- The Stereochemistry of an Elimination Reaction Effected by Butyllithium1 (1953) (18)
- THE METALATION OF SOME ALKYL ANISOLES (1951) (18)
- Selective N-debenzoylation of N,O-polybenzoylucleosides. (1968) (18)
- Photorections of nitroanisoles with cyanide ion. Studies of products and reaction sequence (1969) (17)
- Selective deprotection by reductive cleavage with radical anions (1975) (17)
- The preparation and some properties of 2-methyl-1-propene-1-boronic acid (1953) (17)
- peri-Substituted Naphthalene Compounds. VI.1,2 Acenaphth[1,2-α]acenaphthylene (1964) (16)
- Incorporation of a non-nucleotide bridge into hairpin oligonucleotides capable of high-affinity binding to the Rev protein of HIV-1. (1996) (15)
- The Reactions of Some Organometallic Compounds with Cyclohexene Oxide1 (1952) (14)
- Nucleotide chemistry. XVI. Synthesis of a diribonucleoside monophosphate by the .beta.-cyanoethyl phosphotriester method (1970) (13)
- Orientation in the Cleavage of 2-Methoxyoctane by Organoalkali Metal Compounds1 (1951) (13)
- Photo-Induced Nucleophilic Aromatic Substitution (1964) (13)
- Photoinduced Substitution. IV. Reaction of Aromatic Nitro Compounds with Hydrochloric Acid1,2 (1966) (13)
- Study of conformational changes induced on substituting NH for O at C(51) of thymidine nucleosides and nucleotides. (1977) (13)
- 2,4-Dinitrobenzenesulfenyl as a Blocking Group for Hydroxyl Functions in Nucleosides1 (1964) (13)
- The Preparation of Deoxyguanosine Oligomers on an Insoluble Polymer Support (1971) (13)
- The Preparation of Optically Active Hydrocarbons by the Wurtz Reaction (1948) (13)
- Reactivity of ester groups on insoluble polymer supports (1967) (12)
- Solid support synthesis of oligothymidylates using phosphorochloridates and 1-alkylimidazoles. (1975) (12)
- Enzymatic synthesis of duplex circular phiX174 DNA containing phosphoramidate bonds in the (-) strand. (1976) (12)
- The Reaction of Hydrazine with Some α-Dimethylaminoacetophenones (1952) (12)
- Solvent effects in the photoinduced reactions of nitroaromatics with cyanide ion (1969) (12)
- Selective Catalysis Involving Reversible Association of a Synthetic Polymeric Catalyst and Substrate (1964) (11)
- Photoreactions of nitrobenzene and monosubstituted nitrobenzenes with hydrochloric acid. Evidence concerning the reaction mechanism (1974) (11)
- The Preparation of Allyl Iodide1 (1948) (11)
- Naphthalenedicarboxamides as Fluorescent Probes of Inter- and Intramolecular Electron Transfer in Single Strand, Hairpin, and Duplex DNA (1999) (11)
- Stability and Conformational Switching in a Mini‐Cyclic Oligonucleotide Conjugate (1997) (11)
- Effect of structural variations in cholesteryl-conjugated oligonucleotides on inhibitory activity toward HIV-1. (1991) (10)
- Anchor for one step release of 3′-aminooligonucleotides from a solid support (1993) (10)
- The reaction of allysodium with 2-bromooctane. (1948) (10)
- Chemistry of oligonucleotide-gold nanoparticle conjugates (1999) (10)
- Complementary carrier peptide synthesis: general strategy and implications for prebiotic origin of peptide synthesis. (1979) (10)
- DNA-templated formation and luminescence of diphenylacetylene dimeric and trimeric complexes. (2008) (10)
- Notes- Isomeric Pyranones from Condensation of Propionic Acid with 1,3-Diphenyl-2-propanone (1961) (9)
- peri-Substituted Naphthalenes. I. New Rearrangement Reactions of Substituted Naphthopyrans (1959) (9)
- The Formation of 9-Phenylfluorene and Triphenylmethane by Disproportionation of Triphenylmethyl (1954) (9)
- Organoboron Compounds. XIII. Boronic Acids with Neighboring Unsaturated Groups1 (1961) (9)
- Regulation of Rate of Reaction of a Polyuridylic Acid Derivative by Use of Suppressor and Antisuppressor Molecules1,2 (1966) (9)
- PHOTOREACTIONS OF NITROBENZENE AND MONOSUBSTITUTED NITROBENZENES WITH HYDROCHLORIC ACID, EVIDENCE CONCERNING THE REACTION MECHANISM (1974) (8)
- Use of phosphorus oxychloride in synthesizing nucleotides and oligonucleotides. (1974) (8)
- Organoboron Compounds. XVIII. Bifunctional Binding of Water by the cis-1,2-Cyclopentanediol Ester of 8-Quinolineboronic Acid (1964) (8)
- Reactions of 2-Benzhydrylphenylacetic Acid; A New Pyrone Synthesis1 (1961) (8)
- Tailored hydrophobic cavities in oligonucleotide-steroid conjugates. (1998) (8)
- Organoboron Compounds. II.1 The Preparation of Ethylene Dialkylborinates by the Grignard Reaction (1954) (8)
- N6'-di-O-substituted deoxyadenosine (1968) (8)
- Formation of internucleotide 3'-5' phosphoramidate links by direct coupling of phosphoryl and amino groups. (1975) (8)
- Chemical and Photochemical Ligation of Oligonucleotide Blocks (1997) (8)
- Photoinduced reactions of aromatic nitro compounds with borohydride and cyanide (1971) (8)
- Use of azido group in the synthesis of 5' terminal aminodeoxythymidine oligonucleotides. (1975) (7)
- The Structure of a Photodimer of Dibenzalacetone (1953) (7)
- Deaminase activity of commercial spleen phosphodiesterase. (1968) (7)
- Photoinduced substitution. VIII. Effects of distant substituents on photoinduced aromatic substitution reactions (1970) (7)
- Photo-induced substitution. XI. Photo-induced aromatic substitution, addition, and rearrangement reactions of aromatic ketones (1972) (7)
- OLIGONUCLEOTIDE ANALOGS WITH INTERNUCLEOSIDE PHOSPHITE LINKS (1980) (7)
- Design of a Hydrophobic Fluorescent Probe: An Amide-Linked Bispyrenyl Alcohol. (1997) (7)
- Debenzoylation of N-benzoylnucleoside derivatives with ethylenediamine-phenol (1981) (7)
- THE REACTION OF A SUBSTITUTED ALLYLIC GRIGNARD REAGENT WITH CARBON DIOXIDE (1951) (6)
- AMINOETHYL DIARYLBORINATES; ISOLATION OF A STABLE UNSYMMETRICAL ORGANOBORON COMPOUND (1954) (6)
- Polymerization. V. The Catalytic Polymerization of Butadiene by Phenylsodium and Amylpotassium (1947) (6)
- Notes- Tris(o-methoxymethylphenyl)phosphine (1958) (6)
- Investigation of the torsional angle at the glycosidic bond in 5′‐amino‐5′‐deoxythymidine derivatives by carbon‐13 n.m.r. spectroscopy (1977) (6)
- Photosensitized nucleophilic aromatic substitution (1969) (6)
- Notes - Organoboron Compounds. VII. Alkylarylborinates. (1958) (6)
- A 5'-amino analog of adenosine diphosphate. (1973) (5)
- The Optical Rotation of 2-Chlorobutane (1951) (5)
- Synthesis and properties of oligonucleotides bearing a pendant pyrene group. (1985) (5)
- Photoisomerization of -nitrobenzaldehyde (1970) (5)
- Use of the naphthalene radical ion in deblocking O-methoxytrityl nucleotide derivatives (1975) (5)
- Organoboron Compounds. XVII.1 Chemistry of a Compound with Neighboring Borono, Ethynyl, and Amine Functional Groups2 (1963) (5)
- Poly(oligonucleotide) conjugates: applications in assembling nanoparticles and in detecting DNA sequences. (2001) (4)
- Chemical Synthesis of Oligodeoxyribonucleotides: A Simplified Procedure (1984) (4)
- Kinetics of the Alfin polymerization of styrene and isoprene (1959) (4)
- Phosphoramidate analogs of oligonucleotides. (1970) (3)
- Development in the phosphite-triester method of synthesis of oligonucleotides. (1980) (3)
- STUDY OF CONFORMATIONAL CHANGES INDUCED ON SUBSTITUTING NH FOR O AT C(5′) OF THYMIDINE NUCLEOSIDES AND NUCLEOTIDES (1977) (3)
- Anchor For One‐Step Release of 3′‐Aminooligonucleotides from a Solid Support. (1993) (2)
- Chemistry of Areneboronic Acids with Neighboring Amine Groups (1964) (2)
- Condensations by Sodium. XXVIII. The Metalation of Sodium and Potassium Phenoxides (1945) (2)
- Photochemistry of benzaldehyde in hydrochloric acid. Limitation of the scope of photoreduction-chlorination (1977) (2)
- Hydrolyses of p -Nitrophenyl(Oligodeoxyribonucleotide Succinate)s by Oligodeoxyribonucleotide N -Acetylhistidates on Polycytidylic Acid (1973) (2)
- Use of isobutyloxycarbonyl as a blocking group in preparation of 3'-O-p-monomethyoxytritylthymidine. (1967) (2)
- peri-Substituted Naphthalenes. IV. The Tetrahydro-8-isopropyl-1-naphthoic Acids1 (1960) (2)
- Synthesis and properties of modified oligonucleotides. (1991) (2)
- Hydrolysis of p -Nitrophenyl(deoxyguanylyldeoxyguanosine Succinate) by Deoxyguanylyldeoxyguanosine N -Acetylhistidate on Polycytidylic Acid (1971) (1)
- peri-Substituted Naphthalenes. II. A Rearrangement Involving a 1,5-Aryl Migration1 (1959) (1)
- A REARRANGEMENT INVOLVING A 1,5-PHENYL MIGRATION (1956) (1)
- Control of properties of oligonucleotides by chemical modifications. (1993) (1)
- 2,6-Dimethyl-3,5-Diphenyl-4H-Pyran-4-one (2003) (1)
- peri-Substituted Naphthalenes. III. Acid-induced Rearrangement of 8-Isopropyl-1-naphthoic Acid1 (1959) (1)
- SYNTHESIS OF THYMIDINE OLIGONUCLEOTIDES BY PHOSPHITE TRIESTER INTERMEDIATES (1976) (0)
- Distance-Dependent Optical Properties of Gold Nanoparticles Selective Colorimetric Detection of Polynucleotides Based on the (2013) (0)
- Nanoparticle polyanion-conjugates and methods for use thereof in the detection of analytes (2003) (0)
- Synthesis and properties of polynucleotide recognition molecules (1991) (0)
- SOME DEVELOPMENTS IN THE PHOSPHITE-TRIESTER METHOD FOR SYNTHESIS OF OLIGONUCLEOTIDES (1984) (0)
- SYNTHETIC DNA HAIRPIN WITH STILBENEDIETHER LINKER (2001) (0)
- PHOSPHORAMIDAT-ANALOGA VON OLIGONUCLEOTIDEN (1971) (0)
- The chemistry of oligonucleotide phosphotriesters and phosphoramidates (1978) (0)
- Use of Oligonucleotide Conjugates in Creating Self-Assembling Supramolecular Systems (1998) (0)
- Stabilization of deoxyadenosine/polynucleotide complexes by 3',5'-di-O-benzoyl substituents. (1998) (0)
- NUCLEOTIDE CHEMISTRY PART 20, PHOSPHITE COUPLING PROCEDURE FOR GENERATING INTERNUCLEOTIDE LINKS (1975) (0)
- Dynamics of Photoinduced Charge Transfer and Hole Transport in Synthetic DNA (2001) (0)
- United States Patent ( 19 ) Letsinger 54 METHOD OF DEPROTECTING (2017) (0)
- HYDROLYSES OF P-NITROPHENYL(OLIGODEOXYRIBONUCLEOTIDE SUCCINATE)S BY OLIGODEOXYRIBONUCLEOTIDE N-ACETYLHISTIDATES ON POLYCYTIDYLIC ACID (POLY C) (1973) (0)
- Stereochemical assignment of chiral phosphotriester analogues with Alu I sites. (1996) (0)
- Additions and Corrections-Peri-Substituted Naphthalene Compounds. V. 1,8-Dilitionaphthalene (1962) (0)
- Preparation of Poly(diiododiacetylene), an Ordered Conjugated Polymer of Carbon and Iodine (2006) (0)
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