Robert Lechler

Q: What Schools Are Affiliated With Robert Lechler

Robert Lechler is affiliated with the following schools: Victoria University of Manchester, Imperial College London, Royal Postgraduate Medical School, Lund University, King's College London, King's College, Aberdeen

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According to Wikipedia, Sir Robert Ian Lechler, is a British nephrologist, immunologist, and academic. He specialises in transplantation tolerance and immunology. Since 2004, he has been Professor of Immunology at King's College London. Since 2009, he has been executive director of King's Health Partners.

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Robert Lechler's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression (1998) (2177)
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. (2002) (1459)
Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells (1982) (829)
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease (2007) (763)
Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. (2001) (659)
Identification of a B cell signature associated with renal transplant tolerance in humans. (2010) (640)
Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. (1999) (566)
Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. (2010) (497)
Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. (2007) (489)
Anergic T cells as suppressor cells in vitro. (1994) (432)
Organ transplantation—how much of the promise has been realized? (2005) (381)
Requirement for Leptin in the Induction and Progression of Autoimmune Encephalomyelitis1 (2001) (355)
Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. (2003) (352)
A Novel Pathway of Alloantigen Presentation by Dendritic Cells1 (2004) (334)
Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells (2011) (324)
In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance. (2007) (304)
Splicing by overlap extension by PCR using asymmetric amplification: an improved technique for the generation of hybrid proteins of immunological interest. (1997) (301)
Dendritic cells in transplantation--friend or foe? (2001) (301)
Characterization and Clinical Application of Human CD34+ Stem/Progenitor Cell Populations Mobilized into the Blood by Granulocyte Colony‐Stimulating Factor (2006) (285)
The molecular basis of alloreactivity. (1990) (283)
Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice. (2008) (248)
The complementary roles of deletion and regulation in transplantation tolerance (2003) (247)
Pathways of allorecognition: implications for transplantation tolerance. (2002) (233)
Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients (2011) (222)
Isolation of endothelial cells from murine tissue. (2000) (219)
Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection (2017) (209)
Loss of Direct and Maintenance of Indirect Alloresponses in Renal Allograft Recipients: Implications for the Pathogenesis of Chronic Allograft Nephropathy1 (2001) (208)
Balancing susceptibility to infection and autoimmunity: a role for leptin? (2002) (208)
Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo. (2003) (207)
Leptin accelerates autoimmune diabetes in female NOD mice. (2002) (204)
New spectrum of allorecognition pathways: implications for graft rejection and transplantation tolerance. (2004) (202)
CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+ T cells contributes to their regulatory function (2013) (199)
Anergic T Cells Inhibit the Antigen-Presenting Function of Dendritic Cells1 (2000) (195)
Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials (2020) (194)
Transplant Accommodation in Highly Sensitized Patients: A Potential Role for Bcl‐xL and Alloantibody (2001) (186)
Antigen presentation by keratinocytes induces tolerance in human T cells (1990) (175)
Allorecognition and the alloresponse: clinical implications. (2007) (173)
Differential expression of CTLA‐4 among T cell subsets (2004) (168)
Structural model of HLA-DR1 restricted T cell antigen recognition (1988) (167)
Leptin inhibits the anti‐CD3‐driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines (2002) (165)
Anergic T cells act as suppressor cells in vitro and in vivo (1999) (156)
Immunogenicity of retransplanted rat kidney allografts. Effect of inducing chimerism in the first recipient and quantitative studies on immunosuppression of the second recipient (1982) (155)
Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males (2001) (153)
Translational Mini‐Review Series on Th17 Cells: Induction of interleukin‐17 production by regulatory T cells (2010) (149)
Allorecognition. [Review] [29 refs] (2001) (147)
Pathways of major histocompatibility complex allorecognition. (2008) (145)
MRL/Mp CD4+,CD25- T cells show reduced sensitivity to suppression by CD4+,CD25+ regulatory T cells in vitro: a novel defect of T cell regulation in systemic lupus erythematosus. (2005) (145)
Malignant disease in patients with long-term renal transplants. (1995) (143)
Assessment of the contribution that direct allorecognition makes to the progression of chronic cardiac transplant rejection in humans. (1998) (142)
Significant frequencies of T cells with indirect anti-donor specificity in heart graft recipients with chronic rejection. (2000) (142)
Are primary alloresponses truly primary? (1990) (139)
Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis. (2000) (136)
Frequency of anti-recipient alloreactive helper T-cell precursors in donor blood and graft-versus-host disease after HLA-identical sibling bone-marrow transplantation (1993) (136)
Antigen presentation by mouse CD4+ T cells involving acquired MHC class II:peptide complexes: another mechanism to limit clonal expansion? (2003) (135)
A randomized, double-blind trial of basiliximab immunoprophylaxis plus triple therapy in kidney transplant recipients. (2001) (132)
Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ T regulatory cell subpopulations (2013) (129)
Major histocompatibility complex class II-expressing endothelial cells induce allospecific nonresponsiveness in naive T cells (1996) (128)
Regulatory T cells and transplantation tolerance. (2006) (121)
Strategies for long-term preservation of kidney graft function (2017) (121)
Modified dendritic cells coexpressing self and allogeneic major histocompatability complex molecules: an efficient way to induce indirect pathway regulation. (2004) (120)
The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro. (2007) (120)
Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease. (2003) (118)
Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation (2016) (117)
CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner (2013) (116)
Detection of primary direct and indirect human anti‐porcine T cell responses using a porcine dendritic cell population (1996) (116)
HLA-DP Allele-Specific T Cell Responses to Beryllium Account for DP-Associated Susceptibility to Chronic Beryllium Disease1 (2001) (115)
Human CD4+CD25+ regulatory cells have marked and sustained effects on CD8+ T cell activation (2003) (112)
Antigen recognition influences transendothelial migration of CD4+ T cells. (1999) (112)
The contributions of T‐cell anergy to peripheral T‐cell tolerance (2001) (111)
Applicability, safety, and biological activity of regulatory T cell therapy in liver transplantation (2019) (110)
Immunologic monitoring (2003) (109)
HLA in health and disease (2000) (109)
Regulatory T cell-derived extracellular vesicles modify dendritic cell function (2018) (108)
Anergic T cells effect linked suppression (1997) (107)
Dendritic cells from CML patients have altered actin organization, reduced antigen processing, and impaired migration. (2003) (104)
Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation (2015) (104)
HLA‐G inhibits the transendothelial migration of human NK cells (2000) (103)
The Endogenous Pathway of MHC Class II Antigen Presentation (1996) (103)
Chronic Exposure to Helicobacter pylori Impairs Dendritic Cell Function and Inhibits Th1 Development (2006) (100)
Complete Inhibition of Acute Humoral Rejection Using Regulated Expression of Membrane‐tethered Anticoagulants on Xenograft Endothelium (2004) (99)
Everolimus and Basiliximab Permit Suppression by Human CD4+CD25+ Cells in vitro (2005) (99)
Activated CD1d‐restricted natural killer T cells secrete IL‐2: innate help for CD4+CD25+ regulatory T cells? (2005) (97)
Thy-1+ dendritic epidermal cells belong to the T-cell lineage. (1987) (97)
Acquisition of HLA‐DR and Costimulatory Molecules by T Cells from Allogeneic Antigen Presenting Cells (2005) (97)
MicroRNAs affect dendritic cell function and phenotype (2015) (94)
Helicobacter pylori Stimulates Dendritic Cells To Induce Interleukin-17 Expression from CD4+ T Lymphocytes (2009) (94)
Cognate recognition of the endothelium induces HY-specific CD8+ T-lymphocyte transendothelial migration (diapedesis) in vivo. (2004) (92)
Regulatory T Cells in the Control of Transplantation Tolerance and Autoimmunity (2003) (92)
An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment (2017) (91)
Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1–dependent leukocyte recruitment in vivo (2008) (87)
The T helper 17–regulatory T cell axis in transplant rejection and tolerance (2009) (87)
A Novel Pathway of Antigen Presentation by Dendritic and Endothelial Cells: Implications for Allorecognition and Infectious Diseases (2006) (86)
Antigen presentation by parenchymal cells: a route to peripheral tolerance? (1999) (85)
Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment? (2016) (85)
Modulation of dendritic cell phenotype and functionin an in vitro model of the intestinal epithelium (2006) (85)
Qualitative and quantitative studies of antigen-presenting cell function by using I-A-expressing L cells. (1985) (85)
A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials (2018) (83)
The importance of the indirect pathway of allorecognition in clinical transplantation. (2008) (83)
Allorecognition of DR1 by T cells from a DR4/DRw13 responder mimics self-restricted recognition of endogenous peptides. (1989) (83)
Human T cells cannot act as autonomous antigen-presenting cells, but induce tolerance in antigen-specific and alloreactive responder cells (1992) (83)
Analysis of T cell responses to the autoantigen in Goodpasture's disease (1995) (82)
Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28. (2007) (81)
Antigen presentation by epithelial cells induces anergic immunoregulatory CD45RO+ T cells and deletion of CD45RA+ T cells. (1997) (80)
Indefinite mouse heart allograft survival in recipient treated with CD4(+)CD25(+) regulatory T cells with indirect allospecificity and short term immunosuppression. (2009) (79)
A Multicenter Phase I Gene Therapy Clinical Trial Involving Intraperitoneal Administration of E1A-Lipid Complex in Patients with Recurrent Epithelial Ovarian Cancer Overexpressing HER-2/neu Oncogene (2004) (78)
In Goodpasture's disease, CD4(+) T cells escape thymic deletion and are reactive with the autoantigen alpha3(IV)NC1. (2001) (78)
"Exon-shuffling" maps control of antibody- and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta. (1985) (77)
Generation and Expansion of Human CD4+CD25+ Regulatory T Cells with Indirect Allospecificity: Potential Reagents to Promote Donor-Specific Transplantation Tolerance (2006) (77)
CD4+CD25+ regulatory T cells do not significantly contribute to direct pathway hyporesponsiveness in stable renal transplant patients. (2003) (77)
Presentation and recognition of major and minor histocompatibility antigens. (1994) (76)
T cell‐mediated xenograft rejection: Specific tolerance is probably required for long term xenograft survival (1998) (76)
Comparison of regulatory T cells in hemodialysis patients and healthy controls: implications for cell therapy in transplantation. (2013) (76)
Adult onset immunodeficiency caused by inherited adenosine deaminase deficiency. (1994) (76)
Dendritic cells as a tool to induce transplantation tolerance: obstacles and opportunities. (2011) (75)
Detection of donor-specific hyporesponsiveness following late failure of human renal allografts. (1996) (73)
Renal transplantation following immunoadsorption in highly sensitized recipients. (1993) (73)
Antigen presentation by interferon‐γ‐treated thyroid follicular cells inhibits interleukin‐2 (IL‐2) and supports IL‐4 production by B7‐dependent human T cells (1997) (70)
Co-recognition of endogenous antigens with HLA-DR1 by alloreactive human T cell clones. (1989) (70)
Cutting Edge: CTLA-4 (CD152) Differentially Regulates Mitogen-Activated Protein Kinases (Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase) in CD4+ T Cells from Receptor/Ligand-Deficient Mice1 (2002) (69)
Origin and biology of the allogeneic response. (2013) (69)
An Endogenous Nanomineral Chaperones Luminal Antigen and Peptidoglycan to Intestinal Immune Cells (2015) (68)
Regulatory T cells as therapeutic cells (2008) (67)
Natural regulatory T cells: number and function are normal in the majority of patients with lupus nephritis (2008) (67)
CD4+CD25+ T cells as immunoregulatory T cells in vitro (2002) (66)
Increased frequencies of CD4+CD25high Tregs correlate with disease relapse after allogeneic stem cell transplantation for chronic myeloid leukemia (2007) (66)
Regulatory T Cell-Derived Exosomes: Possible Therapeutic and Diagnostic Tools in Transplantation (2014) (65)
Immobilized anti-CD3 mAb induces anergy in murine naive and memory CD4+ T cells in vitro. (1997) (65)
Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression. (2005) (65)
Interferon-γ-treated renal tubular epithelial cells induce allospecific tolerance (1998) (65)
Detection of CD40 on human thyroid follicular cells: analysis of expression and function. (1998) (65)
Critical role of costimulation in the activation of naive antigen-specific TCR transgenic CD8+ T cells in vitro. (1999) (63)
Aspirin‐Treated Human DCs Up‐Regulate ILT‐3 and Induce Hyporesponsiveness and Regulatory Activity in Responder T Cells (2006) (62)
EVIDENCE THAT UMBILICAL CORD BLOOD CONTAINS A HIGHER FREQUENCY OF HLA CLASS II‐SPECIFIC ALLOREACTIVE T CELLS THAN ADULT PERIPHERAL BLOOD (1992) (62)
Mechanisms of peripheral T‐cell tolerance (1997) (62)
Multiple sclerosis and HLA: is the susceptibility gene really HLA-DR or -DQ? (1991) (61)
Promoting transplantation tolerance; adoptive regulatory T cell therapy (2013) (61)
Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells (2016) (60)
Early genetic events in T cell development analyzed by in situ hybridization (1987) (60)
T-cell alloimmunity and chronic allograft dysfunction. (2010) (60)
Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. (2001) (60)
Antigen presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals. (1996) (59)
The Bioenergetics of the Immune System (2001) (58)
From current immunosuppressive strategies to clinical tolerance of allografts (2007) (57)
Nitric oxide-mediated expression of Bcl-2 and Bcl-xl and protection from tumor necrosis factor-alpha-mediated apoptosis in porcine endothelial cells after exposure to low concentrations of xenoreactive natural antibody. (2001) (57)
COMPARISON OF HELPER AND CYTOTOXIC ANTIRECIPIENT T CELL FREQUENCIES IN UNRELATED BONE MARROW TRANSPLANTATION (1994) (57)
Qualitatively distinct patterns of cytokines are released by human dendritic cells in response to different pathogens (2005) (56)
The Relative Efficiency of Acquisition of MHC:Peptide Complexes and Cross-Presentation Depends on Dendritic Cell Type1 (2008) (56)
Relevance of regulatory T cell promotion of donor-specific tolerance in solid organ transplantation (2012) (56)
T:T antigen presentation by activated murine CD8+ T cells induces anergy and apoptosis. (1998) (55)
Regulatory T cells: tolerance induction in solid organ transplantation (2017) (55)
Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium. (2004) (54)
In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DM. (1997) (53)
Towards the identification of biomarkers of transplantation tolerance (2009) (52)
Cell Therapy in Organ Transplantation: Our Experience on the Clinical Translation of Regulatory T Cells (2018) (52)
IL-13 production by donor T cells is prognostic of acute graft-versus-host disease following unrelated donor stem cell transplantation. (2004) (52)
Feasibility, long-term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients (2020) (51)
Placenta‐derived MSCs are partially immunogenic and less immunomodulatory than bone marrow‐derived MSCs (2011) (51)
Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis.[see comment] (2000) (50)
Achieving permanent survival of islet xenografts by independent manipulation of direct and indirect T-cell responses. (2005) (50)
Selective inhibition of β-1,4- and α-1,3-galactosyltransferases: donor sugar-nucleotide based approach (1999) (49)
Ex Vivo Expanded Human Regulatory T Cells Delay Islet Allograft Rejection via Inhibiting Islet-Derived Monocyte Chemoattractant Protein-1 Production in CD34+ Stem Cells-Reconstituted NOD-scid IL2rγnull Mice (2014) (49)
Porcine CTLA4-Ig Lacks a MYPPPY Motif, Binds Inefficiently to Human B7 and Specifically Suppresses Human CD4+ T Cell Responses Costimulated by Pig But Not Human B71 (2000) (49)
TRANSFERRIN RECEPTOR-MEDIATED GENE TRANSFER TO THE CORNEAL ENDOTHELIUM1 (2001) (49)
Dissociation of T cell anergy from apoptosis by blockade of Fas/Apo-1 (CD95) signaling. (1997) (48)
A 'biomarker signature' for tolerance in transplantation (2010) (48)
A rapid limiting dilution assay for measuring frequencies of alloreactive, interleukin-2-producing T cells in humans. (1992) (47)
Role of donor and recipient antigen-presenting cells in priming and maintaining T cells with indirect allospecificity. (1998) (47)
Aspirin modified dendritic cells are potent inducers of allo-specific regulatory T-cells. (2006) (47)
Activated Murine Endothelial Cells Have Reduced Immunogenicity for CD8+ T Cells: A Mechanism of Immunoregulation?1 (2000) (47)
Multiple Cladosporium brain abscesses in a renal transplant patient: aggressive management improves outcome. (1997) (47)
Regulated inhibition of coagulation by porcine endothelial cells expressing P-selectin-tagged hirudin and tissue factor pathway inhibitor fusion proteins. (1999) (47)
Altered proximal T cell receptor (TCR) signaling in human CD4+CD25+ regulatory T cells (2006) (46)
The development of primed/memory CD8+ lymphocytes in vitro and in rejecting kidneys after transplantation (1990) (46)
Binding of BCR/ABL junctional peptides to major histocompatibility complex (MHC) class I molecules: studies in antigen-processing defective cell lines. (1994) (46)
Allorecognition (2001) (46)
Acquisition of MHC:Peptide Complexes by Dendritic Cells Contributes to the Generation of Antiviral CD8+ T Cell Immunity In Vivo (2012) (46)
Major Histocompatibility Complex Class II-dependent Unfolding, Transport, and Degradation of Endogenous Proteins* (1997) (46)
Adoptive regulatory T cell therapy: challenges in clinical transplantation (2010) (45)
POSITIVE CORRELATION OF T CELL SENSITIZATION WITH FREQUENCIES OF ALLOREACTIVE T HELPER CELLS IN CHRONIC RENAL FAILURE PATIENTS (1992) (45)
I-A-restricted T cell antigen recognition. Analysis of the roles of A alpha and A beta using DNA-mediated gene transfer (1986) (45)
T-cell anergy and peripheral T-cell tolerance. (2001) (44)
Expanded Regulatory T Cells Induce Alternatively Activated Monocytes With a Reduced Capacity to Expand T Helper-17 Cells (2018) (44)
In Vivo SPECT Reporter Gene Imaging of Regulatory T Cells (2011) (44)
The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology (2020) (44)
Direct evidence for a functional role of HLA-DRB1 and -DRB3 gene products in the recognition of Dermatophagoides spp. (house dust mite) by helper T lymphocytes. (1990) (44)
Speculations on the specificity of suppression. (1989) (44)
Molecular mimicry by major histocompatibility complex molecules and peptides accounts for some alloresponses. (1992) (43)
Direct and indirect pathways of alloantigen recognition: relevance to acute and chronic allograft rejection. (1997) (43)
CD152 Ligation by CD80 on T Cells Is Required for the Induction of Unresponsiveness by Costimulation-Deficient Antigen Presentation1 (2000) (42)
Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis (2006) (42)
Monitoring of In Vivo Function of Superparamagnetic Iron Oxide Labelled Murine Dendritic Cells during Anti-Tumour Vaccination (2011) (41)
Transitional‐2 B cells acquire regulatory function during tolerance induction and contribute to allograft survival (2015) (41)
Continuous Acquisition of MHC:Peptide Complexes by Recipient Cells Contributes to the Generation of Anti‐Graft CD8+ T Cell Immunity (2016) (40)
Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism. (2003) (40)
Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV‐gp120‐induced apoptosis (1995) (39)
The invariant chain inhibits presentation of endogenous antigens by a human fibroblast cell line (1994) (39)
The alloresponse. (1999) (39)
A kinetic differentiation model for the action of altered TCR ligands. (1999) (38)
Location of Major Histocompatibility Complex Class II Molecules in Rafts on Dendritic Cells Enhances the Efficiency of T‐Cell Activation and Proliferation (2006) (38)
B-lymphocytes support and regulate indirect T-cell alloreactivity in individual patients with chronic antibody-mediated rejection. (2015) (37)
Relative Resistance of Human CD4+ Memory T Cells to Suppression by CD4+CD25+ Regulatory T Cells (2011) (37)
Inhibition of tissue factor-dependent and -independent coagulation by cell surface expression of novel anticoagulant fusion proteins. (1999) (37)
Induction of tumor-specific T-cell responses by vaccination with tumor lysate-loaded dendritic cells in colorectal cancer patients with carcinoembryonic-antigen positive tumors (2007) (36)
Structural and functional studies of HLA-DR restricted antigen recognition by human helper T lymphocyte clones by using transfected murine cell lines. (1988) (36)
Regulatory B cells: Development, phenotypes, functions, and role in transplantation (2019) (36)
Optimizing a limiting dilution culture system for quantifying the frequency of interleukin-2-producing alloreactive T helper lymphocytes. (1997) (36)
Antigen-specificity using chimeric antigen receptors: the future of regulatory T-cell therapy? (2016) (35)
Myoblasts fail to stimulate T cells but induce tolerance. (1994) (35)
Reversal of HLA restriction by a point mutation in an antigenic peptide. (1989) (35)
Improved protocol for colorimetric detection of complement-mediated cytotoxicity based on the measurement of cytoplasmic lactate dehydrogenase activity. (1996) (35)
The specificity of alloreactive T cells is determined by MHC polymorphisms which contact the T cell receptor and which influence peptide binding. (1991) (34)
Mesenchymal stem cells inhibit T-cell function through conserved induction of cellular stress (2019) (34)
Nox2 in regulatory T cells promotes angiotensin II–induced cardiovascular remodeling (2018) (34)
Infection of mouse bone marrow-derived dendritic cells with recombinant adenovirus vectors leads to presentation of encoded antigen by both MHC class I and class II molecules-potential benefits in vaccine design. (2002) (34)
A correlation between HLA-C matching and donor antirecipient CTL precursor frequency in bone marrow transplantation. (1996) (34)
Position 71 in the α helix of the DRβ domain is predicted to influence peptide binding and plays a central role in allorecognition (1993) (34)
The primary alloresponse of human CD4+ T cells is dependent on B7 (CD80), augmented by CD58, but relatively uninfluenced by CD54 expression. (1995) (34)
Expression of hirudin fusion proteins in mammalian cells: a strategy for prevention of intravascular thrombosis. (1998) (33)
Endothelial cell cytoprotection induced in vitro by allo‐ or xenoreactive antibodies is mediated by signaling through adenosine A2 receptors (2003) (32)
Structural aspects of allorecognition. (1991) (32)
Contribution of T-cell receptor-contacting and peptide-binding residues of the class II molecule HLA-DR4 Dw10 to serologic and antigen-specific T-cell recognition. (1991) (32)
Analysis of the peripheral T‐cell repertoire in kidney transplant patients (2010) (32)
Targeting MHC Class I Monomers to Dendritic Cells Inhibits the Indirect Pathway of Allorecognition and the Production of IgG Alloantibodies Leading to Long-Term Allograft Survival (2010) (31)
Reversibility with interleukin-2 suggests that T cell anergy contributes to donor-specific hyporesponsiveness in renal transplant patients. (2002) (31)
An allelic cluster of DQ alpha restriction fragments is associated with multiple sclerosis: evidence that a second haplotype may influence disease susceptibility. (1989) (31)
Cross-species costimulation: relative contributions of CD80, CD86, and CD40 (2003) (31)
CD4+CD25+ regulatory T-cell therapy for allergy, autoimmune disease and transplant rejection. (2006) (31)
Expression of α-1,3-Galactose and Other Type 2 Oligosaccharide Structures in a Porcine Endothelial Cell Line Transfected with Human α-1,2-Fucosyltransferase cDNA* (1997) (31)
Tolerogenic Donor-Derived Dendritic Cells Risk Sensitization In Vivo owing to Processing and Presentation by Recipient APCs (2013) (30)
Functional Consequences of Noncognate Interactions Between CD4+ Memory T Lymphocytes and the Endothelium1 (2002) (30)
NK‐cell‐dependent acute xenograft rejection in the mouse heart‐to‐rat model (2006) (30)
Unusual chlamydial infection in a human renal allograft recipient. (1978) (29)
HLA-DPB1 mismatch at position 69 is associated with high helper T lymphocyte precursor frequencies in unrelated bone marrow transplant pairs. (1996) (29)
Induction of tumor-specific T-cell responses by vaccination with tumor lysate-loaded dendritic cells in colorectal cancer patients with carcinoembryonic-antigen positive tumors (2007) (29)
Costimulatory blockade by the induction of an endogenous xenospecific antibody response (2000) (29)
Organ transplantation: halfway through the first century. (2004) (28)
Graft dysfunction in chronic antibody-mediated rejection correlates with B-cell–dependent indirect antidonor alloresponses and autocrine regulation of interferon-γ production by Th1 cells (2017) (28)
IL‐2 therapy preferentially expands adoptively transferred donor‐specific Tregs improving skin allograft survival (2019) (28)
Human T cells elicit IFN‐α secretion from dendritic cells following cell to cell interactions (2000) (27)
Association between interleukin-4-producing T lymphocyte frequencies and reduced risk of graft-versus-host disease. (1998) (27)
Tolerant T cells display impaired trafficking ability (2005) (26)
Increased CD40 Ligation and Reduced BCR Signalling Leads to Higher IL-10 Production in B Cells From Tolerant Kidney Transplant Patients (2017) (26)
Helicobacter pylori induces in‐vivo expansion of human regulatory T cells through stimulating interleukin‐1β production by dendritic cells (2012) (26)
Failure of correlation between B7 expression and activation of interleukin‐2‐secreting T cells (1994) (26)
The relationship between MHC restricted and allospecific T cell recognition. (1991) (26)
IMMUNOLOGICAL CONSEQUENCES AND TRAFFICKING OF HUMAN REGULATORY MACROPHAGES ADMINISTERED TO RENAL TRANSPLANT RECIPIENTS (2011) (26)
Galectin-1 is required for the regulatory function of B cells (2018) (25)
Lack of T cell proliferation without induction of nonresponsiveness after antigen presentation by endothelial cells. (1999) (25)
Individual variation in the frequency of HLA class II‐specific cytotoxic T lymphocyte precursors (1990) (25)
Chronic graft loss. Immunological and non-immunological factors. (2005) (25)
Amino Acid Substitutions in the Putative MHC Class II “Dimer of Dimers” Interface Inhibit CD4+ T Cell Activation (2001) (25)
In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance. (2006) (25)
Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model (2015) (25)
PEPTIDE ANALOGUES AS A STRATEGY TO INDUCE TOLERANCE IN T CELLS WITH INDIRECT ALLOSPECIFICITY1 (2000) (24)
Stress-induced modulation of antigen-presenting cell function. (1991) (24)
CLONING OF PORCINE INTERCELLULAR ADHESION MOLECULE-1 AND CHARACTERIZATION OF ITS INDUCTION ON ENDOTHELIAL CELLS BY CYTOKINES1 (2000) (24)
Cell therapy to promote transplantation tolerance: a winning strategy? (2011) (23)
Human thrombin and FXa mediate porcine endothelial cell activation; modulation by expression of TFPI‐CD4 and hirudin‐CD4 fusion proteins (2001) (23)
Rejection mechanisms in transplantation. (2001) (23)
In-vitro generation and characterisation of murine CD4+CD25+ regulatory T cells with indirect allospecificity. (2006) (23)
Structural analysis of anti-DR1 allorecognition by using DR1/H-2Ek hybrid molecules. Influence of the beta 2-domain correlates with CD4 dependence. (1991) (23)
Regenerative repair after endoluminal injury in mice with specific antagonism of protease activated receptors on CD34+ vascular progenitors. (2008) (23)
Interferon-gamma-treated renal tubular epithelial cells induce allospecific tolerance. (1998) (23)
PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype (2021) (23)
Cellular xenoresponses: Although vigorous, direct human T cell anti‐pig primary xenoresponses are significantly weaker than equivalent alloresponses (1996) (23)
Tolerance mechanisms and recent progress. (2004) (22)
The Potency of Allospecific Tregs Cells Appears to Correlate With T Cell Receptor Functional Avidity (2011) (22)
Cell surface expression of hybrid murine/human MHC class II beta alpha dimers. Key influence of residues in the amino-terminal portion of the beta 1 domain. (1990) (22)
Human Tissue Factor Pathway Inhibitor Fused to CD4 Binds both FXa and TF/FVIIa at the Cell Surface (1997) (22)
What Is Direct Allorecognition? (2016) (22)
Expansion of hepatitis C-specific CD4+CD25+ regulatory T cells after viral clearance: a mechanism to limit collateral damage? (2008) (21)
Transplantation tolerance induced by regulatory T cells: in vivo mechanisms and sites of action. (2009) (21)
The cellular rejection of xenografts – recent insights (2003) (21)
MHC class II molecular structure--permitted pairs? (1988) (20)
Markers of achievement for assessing and monitoring gender equity in translational research organisations: a rationale and study protocol (2016) (19)
Differential Role of Naïve and Memory CD4+ T‐Cell Subsets in Primary Alloresponses (2010) (19)
Human anti-mouse xenorecognition. Provision of noncognate interactions reveals plasticity of T cell repertoire. (1995) (19)
Regulation of Rat and Human T-Cell Immune Response by Pharmacologically Modified Dendritic Cells (2009) (18)
Allospecific CD4+ T cells retain effector function and are actively regulated by Treg cells in the context of transplantation tolerance (2015) (17)
APT070 (mirococept), a membrane‐localizing C3 convertase inhibitor, attenuates early human islet allograft damage in vitro and in vivo in a humanized mouse model (2016) (17)
Galectin-1: a key effector of regulation mediated by CD4CD25 T cells Short title: Key role of galectin-1 in regulatory T cells (2006) (17)
Microbiota, immunity and the liver. (2016) (17)
Human T cells elicit IFN-alpha secretion from dendritic cells following cell to cell interactions. (2000) (17)
HLA and Disease (1994) (17)
CD 161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT 3-dependent manner (2013) (17)
Do cyclosporin proffles provide useful information in the management of renal transplant recipients (1996) (16)
Alloantigen‐specific regulatory T cells prevent experimental chronic graft‐versus‐host disease by simultaneous control of allo‐ and autoreactivity (2012) (16)
CD40 can costimulate human memory T cells and favors IL‐10 secretion (2003) (15)
Disordered thromboregulation after xenografting (2001) (15)
Interferon‐α2a is sufficient for promoting dendritic cell immunogenicity (2005) (15)
Absence of Galectin‐1 accelerates CD8+ T cell‐mediated graft rejection (2012) (15)
Progression to renal failure after nephrotoxic nephritis in rats studied by renal transplantation. (1985) (15)
Reversible uraemia in normotensive nephrotic syndrome. (1979) (14)
Basiliximab significantly reduces acute rejection in renal transplant patients given triple therapy with azathioprine. (2001) (14)
The TAP complex influences allorecognition of class II MHC molecules. (1996) (14)
Superantigen-Activated Regulatory T Cells Inhibit the Migration of Innate Immune Cells and the Differentiation of Naive T Cells1 (2009) (14)
Whole‐body imaging of adoptively transferred T cells using magnetic resonance imaging, single photon emission computed tomography and positron emission tomography techniques, with a focus on regulatory T cells (2013) (14)
A T cell clone in association with an Epstein-Barr virus-related B cell lymphoma. (1991) (14)
Co-expression of human T cell receptor chains with mouse CD3 on the cell surface of a mouse T cell hybridoma. (1992) (14)
Neutropenic enterocolitis in a renal transplant patient. (1991) (13)
Induction of apoptosis following antigen presentation by T cells: anergy and apoptosis are two separate phenomena. (1997) (13)
Measurement of cytotoxic T lymphocyte precursor frequencies reveals cryptic HLA class I mismatches in the context of unrelated donor bone marrow transplantation. (1997) (13)
Comparison of the direct and indirect pathways of allorecognition in chronic allograft failure. (2001) (13)
The molecular basis of allorecognition of major histocompatibility complex molecules by T lymphocytes. (1991) (12)
Antigen presentation by murine endothelial cells. (2001) (12)
Adoptive cell therapy using in vitro generated human CD4+ CD25+ regulatory t cells with indirect allospecificity to promote donor-specific transplantation tolerance. (2006) (12)
Transplantation tolerance (2013) (12)
Commentary: Priming of alloreactive T cells – where does it happen? (2004) (12)
Why MHC incompatible grafts induce strong primary alloimmunity. (1982) (12)
Definition of sites on HLA‐DR1 involved in the T cell response to staphylococcal enterotoxins E and C2 (1995) (12)
Disease susceptibility, transplantation and the MHC. (1995) (11)
Anergic T cells act as suppressor cells in vitro. (1995) (11)
Interactions between the amino-terminal domains of MHC class II molecules have a profound effect on serologic and T cell recognition: an analysis using recombinant HLA-DR/H-2E molecules. (1991) (11)
Monitoring the efficacy of dendritic cell vaccination by early detection of 99mTc-HMPAO-labelled CD4+ T cells (2014) (11)
Functional evidence for the recognition of endogenous peptides by autoreactive T cell clones. (1989) (11)
Structure-function relationships of MHC class II molecules. (1988) (11)
Allorecognition. [Review] [30 refs] (2001) (11)
Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug therapy (2020) (10)
Position 71 in the alpha helix of the DR beta domain is predicted to influence peptide binding and plays a central role in allorecognition. (1993) (10)
Distinct effects of CD86‐mediated costimulation on resting versus activated human CD4+ T cells (2005) (10)
Inhibition of Thrombin Receptor Signaling on &agr;-Smooth Muscle Actin+ CD34+ Progenitors Leads to Repair After Murine Immune Vascular Injury (2012) (10)
Transfection of HLA-DR-expressing DAP.3 cells with a cDNA clone encoding the glycosyl phosphatidylinositol-linked form of lymphocyte function associated antigen-3: biochemical features and functional consequences. (1992) (10)
The role of T-cell anergy in the maintenance of donor-specific hyporesponsiveness in renal transplant recipients. (2001) (10)
Helicobacter pylori has Stimulatory Effects on Naive T Cells (2006) (10)
Hypertrophic osteoarthropathy: two unusual causes. (1983) (10)
Determination of fluid properties of the green propellant FLP-106 and related material and component testing with regard to applications in space missions (2012) (9)
Limited regions of the α2-domain α-helix control anti-A2 allorecognition: an analysis using a panel of A2 mutants (1991) (9)
Different regions of the N-terminal domains of HLA-DR1 influence recognition of individual peptide-DR1 complexes. (1994) (9)
Chimeric antigen receptor‐modified human regulatory T cells that constitutively express IL‐10 maintain their phenotype and are potently suppressive (2021) (9)
Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function (2019) (9)
Anti-TNFα therapy—killing two birds with one stone? (2010) (9)
In-vitro generated human CD4(+)CD25(high) regulatory T cells with indirect allospecificity as potential patient-specific reagents to promote donor-specific transplantation tolerance (2007) (9)
Expression of alpha-1,3-galactose and other type 2 oligosaccharide structures in a porcine endothelial cell line transfected with human alpha-1,2-fucosyltransferase cDNA. (1997) (8)
Knockdown of mouse VCAM-1 by vector-based siRNA. (2006) (8)
Recently activated T cells are costimulation-dependent in vitro. (1999) (8)
Transplantation Transplantation tolerance — putting the pieces together (1997) (8)
Do cyclosporin profiles provide useful information in the management of renal transplant recipients? (1996) (8)
Comparison of Neoral and Sandimmune preparations in renal transplant patients--improved pharmacokinetics with neoral. (1996) (8)
Reduced TCR Signaling Contributes to Impaired Th17 Responses in Tolerant Kidney Transplant Recipients (2018) (8)
“ACCOMMODATED” PIG ENDOTHELIAL CELLS PROMOTE NITRIC OXIDE-DEPENDENT Th-2 CYTOKINE RESPONSES FROM HUMAN T CELLS1 (2001) (8)
CD4+CD25+ regulatory T cell therapy for the induction of donor-specific clinical transplantation tolerance (2006) (8)
Infectious tolerance? Mechanisms and implications. (2001) (8)
Interferon-alpha2a is sufficient for promoting dendritic cell immunogenicity. (2005) (8)
Structural analysis of human anti-mouse H-2E xenorecognition: T cell receptor bias and impaired CD4 interaction contribute to weak xenoresponses. (1992) (8)
Mechanisms of HLA and Disease Associations (2000) (8)
B lymphocytes contribute to indirect pathway T cell sensitization via acquisition of extracellular vesicles (2020) (7)
Inhibition of expression of the Galα1-3Gal epitope on porcine cells using an intracellular single-chain antibody directed against α1,3Galactosyltransferase (1999) (7)
Allele-specific variation in the degeneracy of major histocompatibility complex (MHC) restriction. (1997) (7)
CD4+CD25+ regulatory T-cell therapy (2006) (7)
A monoclonal antibody with broad anti-HLA-DR activity fails to bind to DRw11/Dw5: Possible effect of a unique polymorphism on the β1 domain α-helix (1991) (7)
Acquisition of MHC:peptide complexes by mouse CD4+ T cells may play a role in T-cell-mediated immunoregulation. (2002) (7)
Production of a cytotoxic human monoclonal antibody with specificity for HLA-DR4 and -DRw10 by cells derived from a highly sensitized kidney recipient. (1990) (7)
Selective inhibition of beta-1,4- and alpha-1,3-galactosyltransferases: donor sugar-nucleotide based approach. (1999) (7)
Leptin in intestinal inflammation: good and bad gut feelings (2004) (6)
Endogenous pathway of class II presentation. (1995) (6)
Helper T-lymphocyte precursor frequencies predict risks of graft-versus-host disease in bone marrow transplantation. (1993) (6)
Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment (2020) (6)
Biased TCR gene usage in alloreactive T cells specific for a structurally dissimilar MHC alloantigen. (1994) (6)
Biased T-cell receptor usage is associated with allelic variation in the MHC class II peptide binding groove (1999) (6)
Hard graft? Future challenges in transplantation. (1991) (6)
Translational Research in the Time of COVID-19—Dissolving Boundaries (2020) (5)
NK cells inhibit T-cell responses: LFA3+ but not LFA3- T-cell responses are suppressed. (1991) (5)
Constitutive expression of the anti‐apoptotic Bcl‐2 family member A1 in murine endothelial cells leads to transplant tolerance (2017) (5)
DEVELOPING A PORCINE TRANSPLANTATION MODEL: EFFICIENT GENE TRANSFER INTO PORCINE VASCULAR CELLS (2004) (5)
Recognition of the HLA class II-peptide complex by T-cell receptor: reversal of major histocompatibility complex restriction of a T-cell clone by a point mutation in the peptide determinant. (1989) (5)
Xenotransplantation: immune barriers beyond hyperacute rejection (1997) (5)
Transplantation tolerance--putting the pieces together. (1997) (5)
Assessment of the immunological contribution to Chronic Allograft Nephropathy (2000) (5)
Establishing the optimal method to estimate the frequencies of alloreactive CD4+ T cells. (2002) (5)
Structure and function of murine class II major histocompatibility complex genes. (1986) (5)
Quantitating Effector and Regulatory T Lymphocytes in Immune Responses by Limiting Dilution Analysis Modeling 1 (2005) (4)
The ONE Study: Evaluation of Regulatory Cell Therapy in Kidney Transplantation Using a Harmonized Trial Design (2020) (4)
Can the thymus be a useful tool to induce specific tolerance to xenoantigens? (1999) (4)
Use of a murine T-cell hybridoma expressing human T-cell receptor α- and β-gene products as a tool for the production of human T-cell receptor-specific monoclonal antibodies (1992) (4)
Limited regions of the alpha 2-domain alpha-helix control anti-A2 allorecognition: an analysis using a panel of A2 mutants. (1991) (4)
Dendritic cells prohibited by anergic T cells acquire tolerogenic properties. (2002) (4)
BASILIXIMAB (SIMULECT®) SIGNIFICANTLY REDUCES THE INCIDENCE OF ACUTE REJECTION IN RENAL TRANSPLANT PATIENTS RECEIVING TRIPLE THERAPY WITH AZATHIOPRINE.: Abstract# 166 Poster Board #‐Session: P13‐I (2000) (4)
Humanized Mice as Preclinical Models in Transplantation. (2016) (4)
Individual variation in alloresponsiveness and the molecular basis of allorecognition. (1990) (4)
A pig allograft model of antibody-mediated rejection. (2008) (4)
Analysis of accessory signaling in human T-cell clones. (1993) (4)
Could analysis of helper T-cell precursor frequencies be used as a predictive parameter in renal transplantation? (1995) (4)
Human CD41CD251 cells: a naturally occurring population of regulatory T cells (2001) (3)
Tolerance induction in indirect alloresponses by analogs of HLA-derived peptides. (2001) (3)
"Accomodated" pig endothelial cells promote nitric oxide-dependent Th-2 cytokine responses from human T cells. (2001) (3)
Retrospective tissue typing of the kidney donor from recipient urine. (2008) (3)
HLA‐DR Matching and Immune Regulation (2004) (3)
Do endothelial cells fit the paradigm of antigen-presenting cells? (1997) (3)
Quantitative but not qualitative variation in MHC class II alters CD4 interaction and influences T cell repertoire formation. (1997) (3)
Regulatory T cells (2003) (3)
Transfected murine cells expressing HLA class II can be used to generate alloreactive human T cell clones. (1994) (3)
Specificity Analysis of DRA Fragments in Core Cell Lines (1989) (3)
Structural relationship between HLA-A2-restricted and anti-A2 allospecific T-cell recognition: analysis by mutation of the codons for polymorphic and conserved residues. (1991) (3)
Isolation and expansion of thymus‐derived regulatory T cells for use in pediatric heart transplant patients (2021) (3)
P713 - Limiting dilution analysis; Increasing the sensitivity and specificity of the alloreactive T helper cell assay by abrogating “Unwanted” IL-2 production (1996) (3)
Inhibition of expression of the Galalpha1-3Gal epitope on porcine cells using an intracellular single-chain antibody directed against alpha1,3galactosyltransferase. (1999) (2)
EXPRESSION OF NOVEL ANTICOAGULANT FUSION PROTEINS INHIBITS FACTOR XA‐ AND THROMBIN‐INDUCED ACTIVATION OF PORCINE VASCULAR ENDOTHELIAL CELLS.: Abstract# 1042 (2000) (2)
Use of molecular techniques for analysis of Ia structure-function relationships. (1985) (2)
Biomarkers of tolerance in kidney transplants (2007) (2)
Molecular genetics of the human MHC (2000) (2)
PTU-122 A Gmp Treg Expansion Protocol Restores Treg Suppressor Function In End-stage Liver Disease; Implications For Adoptive Transfer Therapy (2014) (2)
Graft Rejection: Immunological Suppression (2010) (2)
Human CD4+ CD25+ T cells regulate CD8+ T-cell activation. (2002) (2)
EVIDENCE THAT TREATMENT WITH DHRS9+ REGULATORY MACROPHAGES INDUCED BY FCγRIII LIGATION AND IFN-γ STIMULATION PROMOTES RENAL ALLOGRAFT TOLERANCE IN PATIENTS: 3261 (2010) (2)
High frequency of alloreactive T cells is a consequence of the presentation of many peptides by allogeneic MHC molecules. (1995) (2)
INDICES OF TOLERANCE: INTERIM REPORT. (2006) (2)
Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency (2021) (2)
Regulation of endothelial cell function by anergic T cells (2000) (2)
P135 - Molecular basis of HLA-DP-associated susceptibility to beryllium disease (1996) (2)
Generation and characterization of an HLA-DRα-specific monoclonal antibody using L-cell transfectants expressing human and mouse class II major histocompatibility dimers (2004) (2)
Do functional assays have predictive value in sibling bone marrow transplantation? (2000) (2)
More brickbats than bouquets? (2010) (2)
The credentials of a T-cell epitope. (1995) (2)
Creating a “Transcampus” in Diabetes Research Between King’s College London and the Technische Universität Dresden: Update on Islet Biology and Transplantation (2014) (2)
A GMP Treg Expansion Protocol Restores Treg Suppressor Function in End-Stage Liver Disease; Implications For Adoptive Transfer Therapy.: Abstract# 2270 (2014) (2)
Advances in Liver Transplantation: where are we in the pursuit of transplantation tolerance? (2021) (2)
" Exon-shuffling " maps control of antibody-and T-cell-recognition sites to the NH 2-terminal domain of the class II major histocompatibility polypeptide A 8 ( gene transfer / hiistocompatibility antigens / immune response / antigen presentation ) (2003) (2)
CD4 + CD25 + Regulatory T Cell Therapy for the Induction of Clinical Transplantation Tolerance (2008) (1)
Absence of Anti-Donor Specific Antibodies in Drug-Free Tolerant Kidney Transplant Recipients: 1920 (2012) (1)
Successful in vivo transfection of non-dividing endothelium by DAPI-supplemented liposome-packaged DNA (2003) (1)
Chronic Antibody-Mediated Rejection: B-Cell Dependent Alloreactive IFN gamma-Producing CD4+ T Cells Could Be Used as a Biomarker To Determine Responsiveness to Therapy (2012) (1)
Leptinmodulates theT-cell immune responseand reversesstarvation-induced immunosuppression (1)
The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease (2021) (1)
Use of SPECT Reporter Gene for Tracking of Regulatory T Cells in Adoptive Transfer Therapy for Skin Transplantation: a Pre-Clinical Model: 430 (2012) (1)
Tolerance versus Sensitisation against Donor Hla-Dr Antigens in Patients on Dialysis following Renal Transplant Failure (1993) (1)
Regulated endothelial cell expression of novel anticoagulants: a strategy for the prevention and therapy of intravascular thrombosis. (2000) (1)
Prevention of co-stimulation molecule expression using intracellular CTLA4: A novel strategy for induction of T cell anergy (2003) (1)
T cell receptor engagement can influence T cell motility. (2001) (1)
Use of a murine T-cell hybridoma expressing human T-cell receptor alpha- and beta-gene products as a tool for the production of human T-cell receptor-specific monoclonal antibodies. (1992) (1)
F.96. T Cell Repertoire Analysis of Stable Kidney Graft Recipients for Detection of Low and High Risk of Chronic Rejection (2008) (1)
Cellular Methods in Testing Histocompatibility (2000) (1)
P1311 : Thril; pilot study evaluating the safety and efficacy profile of regulatory T cell therapy in liver transplant recipients (2015) (1)
Don Craig Wiley (1944–2001) (2002) (1)
Costimulated by Pig But Not T Cell + Specifically Suppresses Human CD 4 Binds Inefficiently to Human B 7 and Porcine CTLA 4-Ig Lacks a MYPPPY Motif (2000) (1)
33: Increased CD4+CD25high+ regulatory T-cell are associated with disease relapse after allogeneic stem cell transplantation (SCT) for chronic myeloid leukaemia (CML) (2007) (1)
Reversal of an immune response gene effect by point mutation in the antigen sequence. (1989) (1)
with potential in clinical immunosuppression Creation of tolerogenic human DC via intracellular CTLA4: a novel strategy (2012) (1)
Endogenous peptides contribute to the ligand recognized by anti-DR1 human alloreactive T cells. (1989) (1)
Induction of specific unresponsiveness in kidney transplant recipients. (1981) (1)
Helper T-cell hybridomas as cellular probes for immunological investigation. (1988) (1)
Dendritic Cells in Transplantation— Review Friend or Foe? (2001) (1)
Generation of CD4+CD25+ regulatory T cells with indirect alloresponses by T cell receptor gene transfer: A novel therapeutic agent for the induction of transplantation tolerance. (2007) (1)
Differential effect of memory, naive and transitional B cells in autologous CD4(+) T cell proliferation, activation and cytokine production (2011) (0)
Major Histocompatibility Complex Class II-expressing Endothelial Ceils Induce Allospecific Nonresponsiveness in Naive T Ceils (2003) (0)
Apoptosis of the APC is concurrent with successful antigen presentation (2001) (0)
Primary Epstein-Barr virus infection associated with a rejection episode in a human renal allograft recipient. (1980) (0)
2013 EACME Annual Conference (2013) (0)
[Alloreactive helper T cell responses in kidney transplant patients]. (2000) (0)
Radiolabelling of Polyclonally Expanded Human Regulatory T Cells (Treg) with 89Zr-oxine for Medium-Term In Vivo Cell Tracking (2023) (0)
Cellsng Function of Dendritic Anergic T Cells Inhibit the (2017) (0)
EncephalomyelitisProgression of Autoimmune Requirement for Leptin in the Induction and (2001) (0)
Cross-Presentation Depends on Dendritic Cell MHC:Peptide Complexes and The Relative Efficiency of Acquisition of (2013) (0)
THE INDUCTION AND REGULATORY ROLE OF ANERGIC T CELLS IN TRANSPLANT TOLERANCE (1999) (0)
Evidence of self-HLA restriction in CD4+CD25+ regulatory cells (2002) (0)
Reply to letter by Webb et al. (1989) (0)
Analysis of sub-populations of CD4(+)CD25(hi) regulatory T cells in healthy individuals and patients with end-stage renal disease awaiting transplantation (2010) (0)
Tolerance Related Gene Expression in Urine from Kidney Transplant Recipients (2013) (0)
IN VITRO ‘ACCOMMODATED’ ENDOTHELIAL CELLS INDUCE A NITRIC OXIDE‐DEPENDENT TH‐2 PATTERN OF CYTOKINE PRODUCTION FROM HUMAN CD4+ T CELLS.: Abstract# 557 Poster Board #‐Session: P195‐II (2000) (0)
Induction of indirect pathway antigen-specific tolerance by plasmacytoid DCs (2008) (0)
Clinical Xenotransplantation of Porcine Organs: Immune Barriers beyond Hyperacute Rejection (1997) (0)
Defects and Amplification of Costimulation Across the Species (2002) (0)
from Receptor/Ligand-Deficient Mice T Cells + c-Jun N-Terminal Kinase) in CD4 (Extracellular Signal-Regulated Kinase and Regulates Mitogen-Activated Protein Kinases Cutting Edge: CTLA-4 (CD152) Differentially (2002) (0)
The development of a pig allograft model as a surrogate for hyperacute rejection in xenotransplantation (2003) (0)
Dfiversfity off gut mficrolora fis requfired ffor the generatfion off B cel wfith regulatory propertfies fin a skfin grafft model (0)
Should clinicians have a role in financial decision making in the NHS? (2017) (0)
Unresponsiveness by Costimulation-Deficient Required for the Induction of CD 152 Ligation by CD 80 on T Cells (2000) (0)
Human CD4+CD25+ cells: A unique population of regulatory cells (2002) (0)
From Bench to Clinic: Translating Biomarkers of Tolerance in Renal Allograft Recipients: 1535 (2012) (0)
Xenotransplantation : basic research and clinical applications (2002) (0)
2013 The British Society for Immunology Congress (2013) (0)
ADVANCES IN IMMUNE MONITORING IN RENAL TRANSPLANTATION (2006) (0)
Antigen Presentation by Activated Murine CD 8 1 T Cells Induces Anergy and Apoptosis 1 (1998) (0)
B Cells from Tolerant Kidney Transplant Recipients Produce High Levels of CD40L-Mediated IL-10 and Inhibit Th1 Responses after Donor-Antigen Presentation.: Abstract# A2977 (2014) (0)
Alloantigen reactive human regulatory T cells, expanded using the 'optimal' antigen presenting cell: implications for clinical application (2013) (0)
H-pylori infection of DC can lead to inhibition of IL-12 release by DC and INF-gamma production by T-cell (2005) (0)
Steroid Withdrawal Kidney Transplant Recipients Normalise Their Proportion of Transitional B Cells in Periphery, Contrary to the Absence of Change in Gene Expression.: Abstract# A27 (2014) (0)
Transendothelial Migration of CD4 Antigen Recognition Influences (1998) (0)
Repertoire analysis of influenza hemagglutin 306–319 peptide specific T-cell clones restricted by two closely related HLA-DR 3olecule: DRβ 0101 and 0103 (1994) (0)
NITRIC OXIDE-MEDIATED EXPRESSION OF Bcl-2 AND Bcl-xl AND PROTECTION FROM TUMOR NECROSIS FACTOR-&agr;-MEDIATED APOPTOSIS IN PORCINE ENDOTHELIAL CELLS AFTER EXPOSURE TO LOW CONCENTRATIONS OF XENOREACTIVE NATURAL ANTIBODY1 (2001) (0)
Proteomics Analysis of Naturally Occurring CD4+/CD25+ Regulatory T Cells. (2007) (0)
Lymphocytes and the Endothelium Memory T + Interactions Between CD4 Functional Consequences of Noncognate (2002) (0)
cells Human CD4+CD25+ cells: a naturally occurring population of regulatory T (2013) (0)
What does the alloreactive T cell see (1991) (0)
A limiting dilution assay to determine the frequencies of IL-4-producing human alloreactive T helper cells (1995) (0)
2013 The 3rd ESOT Basic Science Meeting/ 13th TTS Basic Science Symposium (2013) (0)
IN VIVO HOMEOSTASIS AND EFFECTOR FUNCTION OF DONOR- SPECIFIC CD4+CD25+ REGULATORY T CELLS IN EXPERIMENTAL TRANSPLANTATION TOLERANCE (2006) (0)
Designer meetings (2002) (0)
Graft Rejection: Immunological (2010) (0)
Specific expression of human tissue factor pathway inhibitor fusion protein on vascular smooth muscle cells of transgenic mice (2001) (0)
T2 B Cells Are Expanded During Experimental Tolerance Protocol and Contribute to Skin Graft Survival: 1634 (2012) (0)
Role of the naive and memory CD4+T-cell repertoire in transplantation (2009) (0)
reduced antigen processing, and impaired migration Dendritic cells from CML patients have altered actin organization, (2013) (0)
Acute and chronic nephritides: two different diseases? (1983) (0)
Polymorphic Restriction Fragments Detected with HLA-DQα Discriminate Between DR2-Positive Multiple Sclerosis Patients and Healthy Controls (1989) (0)
IN VITRO ‘ACCOMMODATION’ OF PORCINE ENDOTHELIAL CELLS BY HUMAN ANTI‐PIG XENOREACTIVE NATURAL ANTIBODIES IS MEDIATED IN PART THROUGH LIGATION OF ADENOSINE RECEPTORS.: Abstract# 137 (2000) (0)
Optimisation of Treg cells functions by alteration of in vitro culture conditions (2010) (0)
Identification of tolerant patients based on a combinational analysis of foxp3 and aMannosidase transcription (2007) (0)
Is it possible totissue type a kidney donor who is no longer available (2007) (0)
RFLP Standardization Report for DP Beta/EcoRI (1989) (0)
Induction of tolerance in murine T cells with direct anti-pig specificity (2001) (0)
Role of Type I IFN in DC and T cells maturation and differentiation (2000) (0)
Quantitation and Manipulation of Alloimmune Responses (1993) (0)
The Functional Contribution of the Mhc Class II α2 Domain to T Cell Recognition (1995) (0)
CD40 and reduced BCR signalling leads to higher IL-10 production in B-cells from tolerant kidney transplant patients. (2016) (0)
THROMBIN PROMOTES ANOMALOUS DIFFERENTIATION OF VASCULAR PROGENITOR CELLS DURING NEOINTIMAL HYPERPLASIA AFTER WIRE-INDUCED INJURY (2007) (0)
IMMUNE CONTRIBUTIONS TO CHRONIC ALLOGRAFT NEPHROPATHY: INDIRECT MECHANISMS.: Abstract# 530 Poster Board #‐Session: P170‐II (2000) (0)
9 – Ia Structure and Immune Recognition (1988) (0)
FRI-129-A defect in the Nrf2/HO-1 pathway and Nox2 activation results in regulatory T cell mitochondrial dysfunction in alcohol related cirrhosis (2019) (0)
196. Genetic Manipulation of Dendritic Cells through the Use of Immunolipoplexes To Induce T Cell-Specific Tolerance In Vivo (2006) (0)
Galectin-1 is required for the regulatory function of B cells (2018) (0)
In vivo imaging of T-regulatory cell mediated transplant tolerance (2010) (0)
2012 The 24th INTERNATIONAL CONGRESS OF THE TRANSPLANTATION SOCIETY (2012) (0)
Author Correction: Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model (2020) (0)
CREATION OF TOLEROGENIC ANTIGEN PRESENTING CELLS VIA INTRACELLULAR CTLA4: A NOVEL STRATEGY WITH POTENTIAL CLINICAL UTILITY IN TRANSPLANTATION. (2004) (0)
Tracking Donor-Reactive T Cells: Perspectives for the Development of Tolerance Protocols. (2015) (0)
An alliance with Miltenyi Biotec in the fight for tolerance: A venture into no man's land (2014) (0)
Regulatory T cell-derived extracellular vesicles modify dendritic cell function (2018) (0)
2013 American Transplant Congress (2012) (0)
Infectious tolerance? Mechanisms and implications. [Review] [46 refs] (2001) (0)
REVERSAL OF COSTIMULATION BY CELL SURFACE EXPRESSION OF AN ANTI‐CD152 SINGLE CHAIN ANTIBODY.: Abstract# 887 Poster Board #‐Session: P144‐III (2000) (0)
Immunosuppression by blocking the t-zellencostimulierungssignales 2 (B7 / CD28 interaction) (1999) (0)
NITRIC OXIDE‐MEDIATED INDUCTION OF BCL‐2 AND BCL‐XL IN PORCINE ENDOTHELIAL CELLS AFTER EXPOSURE TO LOW CONCENTRATIONS OF XENOREACTIVE NATURAL ANTIBODY.: Abstract# 136 (2000) (0)
A monoclonal antibody with broad anti-HLA-DR activity fails to bind to DRw11/Dw5: possible effect of a unique polymorphism on the beta 1 domain alpha-helix. (1991) (0)
Xenograft rejection suppression. (1999) (0)
A population of CD25+CD4+regulatory cells that recognise hepatitis C virus antigens can be identified following clearance of infection (2002) (0)
The question as to why major histocompatibility complex (MHC) a antigens are uniquely powerful primary immunogens and in this respect differ from antigens of the minor systems (2003) (0)
Expression of toll-like receptors by intestinal epithelial cells in an in vitro M cell model (2004) (0)
The potential of Tregs with indirect allo-specificity to induce transplantation tolerance (2011) (0)
Cell Reports Resource An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th 2-like Tregs that Support a Tumorigenic Environment (0)
Differential effect of type 1 IFN subtypes on T cell proliferation and survival (2000) (0)
Xenotransplantation: Will Pigs Fly? (2002) (0)
Allograft Survival Alloantibodies Leading to Long-Term of Allorecognition and the Production of IgG Dendritic Cells Inhibits the Indirect Pathway Targeting MHC Class I Monomers to (2010) (0)
Mechanisms underlying the acceptance of human renal allografts (2001) (0)
Time-Course In Vivo Trafficking Pattern and Effector Function of Donor-Specific Regulatory T Cells in Response to an Allograft. (2009) (0)
DENDRITIC CELLS AND IMMUNOGENICITY OF RAT KIDNEY GRAFTS (2003) (0)
APCs Processing and Presentation by Recipient Risk Sensitization In Vivo owing to Tolerogenic Donor-Derived Dendritic Cells (2013) (0)
Peptide analogues inhibit in vitro the response of T cells with indirect allospecificity and may be used as a strategy to prolong graft survival (1997) (0)
An RFLP Study of HLA-D Gene Polymorphism in Multiple Sclerosis (1989) (0)
The Immune System (2001) (0)
P514 - HLA-DM influences MHC class II peptide occupancy independently of the Ii chain (1996) (0)
Customised immunosuppression. (1994) (0)
Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival (2023) (0)
INFERIOR GRAFT SURVIVAL IN PATIENTS TRANSPLANTED OVERSEAS: A SUMMARY OF UK DATA (2009) (0)
Porcine CTLA4-Ig as a specific reagent to prevent direct pathway xenospecific T cell sensitization (2003) (0)
O71 - In the absence of Ii, MHC class II molecules display a distinct set of self peptides (1996) (0)
Regulated endothelial cell expression of novel molecules with anticoagulant properties: A strategy for the prevention and therapy of vascular rejection (1999) (0)
THE ROLE OF T CELL ANERGY IN DONOR SPECIFIC HYPORESPONSIVENESS IN RENAL TRANSPLANTS PATIENTS.: Abstract# 535 Poster Board #‐Session: P174‐II (2000) (0)
cells promote experimental transplantation tolerance specific CD4+CD25+ regulatory T - expanded donor alloantigen - In vitro (2013) (0)
ExVivo Expanded Human Regulatory T Cells Delay Islet Allograft Rejection via Inhibiting Islet-Derived Monocyte Chemoattractant Protein-1 Production in CD34 + Stem Cells-Reconstituted NOD-scidIL2r c null Mice (2014) (0)
CROSS-PLATFORM BIOMARKER SIGNATURE TO IDENTIFY RENAL TRANSPLANT TOLERANCE IN HUMANS.: 3352 (2010) (0)
TRANSPLANT ACCOMMODATION IS ASSOCIATED WITH UP-REGULATION OF ANTI-APOPTOTIC PROTEINS: IN VITRO MODELS IMPLICATE iNOS INDUCTION BY LOW LEVELS OF ANTI-DONOR ANTIBODY IN ACCOMMODATED ENDOTHELIAL CELLS (1999) (0)
PORCINE CTLA4‐IG PREFERENTIALLY SUPPRESSES HUMAN CD4+ T CELL RESPONSES CO‐STIMULATED BY PORCINE BUT NOT HUMAN B7.: Abstract# 1099 (2000) (0)
Expression of B cell genes related with tolerance in kidney transplant recipients (2010) (0)
The Immune Response to Alloantigens (2000) (0)
Author Correction: Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model (2020) (0)
Susceptibility to Chronic Beryllium Disease Beryllium Account for DP-Associated HLA-DP Allele-Specific T Cell Responses to (2001) (0)
Donor-specific inhibition of xenoreactive T cells in vitro and in vivo (2000) (0)
Acquisition of MHC:peptide complexes by dendritic cells contributes to viral immunity in vivo (2010) (0)
running title: Anti-Inflammatory Properties Of Anergic T lymphocytes (2003) (0)
Studies of MHC Class II Restricted Antigen Recognition by Human T Cell Clones Using Transfectant Antigen-Presenting Cells (APC) (1989) (0)
Recognition of the HLA Class II-Peptide Complex by T cell Receptor: Reversal of MHC Restriction of a T Cell Clone by a Point Mutation in the Peptide Determinant (1989) (0)
Correspondence Malnutrition and Variability in CD4 + Cell Counts (2007) (0)
INTRABODY MEDIATED INHIBITION OF VCAM EXPRESSION ON PORCINE ENDOTHELIAL CELLS AS A STRATEGY TO PREVENT RECRUITMENT OF HUMAN MONONUCLEAR LEUKOCYTES IN XENOTRANSPLANTATION.: Abstract# 1023 (2000) (0)
Costimulation across the species barrier: A role for CD40 in the direct xenogeneic pathway (2001) (0)
Author response for "Isolation and expansion of thymus‐derived regulatory T cells for use in paediatric heart transplant patients" (2021) (0)
Defining Mechanisms of “Accommodation” in Human Renal Transplants (2000) (0)
Target specificity of immunoregulation by natural killer cells. (1989) (0)
Stimulates Dendritic Cells to Induce IL-17 Expression From 1 CD 4 + T lymphocytes 2 Short running title : DCs and H . pylori-induced IL-17 production 3 (2009) (0)
Monitoring peripheral blood regulatory T cells on clinically defined groups of kidney transplant recipients (2007) (0)
A preliminary analysis of mice expressing human tissue factor pathway inhibitor in microvascular endothelial cells (2001) (0)
Molecular Mechanisms of T Cell-Induced Unresponsiveness (1993) (0)
Prospects for the Induction of Transplant Tolerance Using Dendritic Cells (2013) (0)
Alloreactive IFN gamma-Producing CD4+T-Cells from Renal Transplant Recipients with Chronic Antibody-Mediated Rejection (CAMR) Are B-Cell Dependent In Vitro. (2011) (0)
Im Praxistest - Mehrverbrauch durch Retarder? / Practical test - higher consumption caused by retarders (2009) (0)
Regulatory T cell populations in goodpasture's disease and Alport's syndrome (2001) (0)
Subversion of human CD4(+)CD25(+) regulatory T cells to IL-17-producing T cells by an inflammatory milieu (2009) (0)
2012 BTS 15TH ANNUAL CONGRESS (2012) (0)
RFLP Standardization Report for DO Beta/EcoRI (1989) (0)
Finding the balance between regulation and deletion for the induction of transplantation tolerance (2007) (0)
2014 British Transplant Society Conference (DECISIONS) (2014) (0)
World Transplant Congress 2006 LEUKOCYTE TRAFFICKING I: CYTOKINES, CHEMOKINES AND ADHESION MOLECULES analysed at rest or after cytokine treatment by PE-labelled, commercially available, anti-chemokine receptor antibodies against CCR1, CCR2, CCR5, CCR7 and CXCR3 with flow cytometry on a BD FACScalibu (2006) (0)
COSTIMULATORY BLOCKADE BY THE INDUCTION OF AN ENDOGENOUS XENOSPECIFIC ANTIBODY RESPONSE.: Abstract# 492 Poster Board #‐Session: P132‐II (2000) (0)
THE INFLUENCE OF AN INFLAMMATORY MILIEU ON ANTIGEN PRESENTATION - A POSSIBLE ROUTE TO AUTOIMMUNITY (1995) (0)
Studying frequencies of alloreactive T cells (2000) (0)
Immunosuppresssion par blocage du signal de co-activation des lymphocytes t (interaction b7/cd28) (1999) (0)
The role of CD25+regulatory cells in restoring tolerance in autoimmune anti-GBM (Goodpasture's) disease. (2002) (0)
The Role of Leptin in the Cell-Mediated Immune Response and T Lymphocyte Development (1999) (0)
RFLP Standardization Report for DQ Beta/EcoRI (1989) (0)
Modulation of Dendritic Cell Function by Protease Activated Receptor 4 (2018) (0)
Transplant Recipients Macrophages Administered to Renal and Trafficking of Human Regulatory Cutting Edge: Immunological Consequences (2011) (0)
A Validated RT-PCR Based Gene Signature for Tolerance in Kidney Transplant Recipients: 1787 (2012) (0)
Subversion of Human CD4+CD25+Regulatory T Cells to IL-17-Producing T Cells by Pathogen-induced Inflammatory Milieu (2008) (0)
Expansion of highly suppressive and non-plastic human regulatory T cells in the presence of rapamycin and all-trans-retinoic acid (2011) (0)
Higher IL10 Production by Transitional B Cells in Tolerant Kidney Transplant Recipients: 2169 (2012) (0)
Studies on the immunogenicity of rat kidney allografts (1984) (0)
anticoagulants hybrid proteins linked to cell membranes. (1998) (0)
RFLP Standardization Report for DR Beta/EcoRI (1989) (0)

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