David C. Rubinsztein
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Wellcome Trust Principal Research Fellow and Professor of Molecular Neurogenetics at the University of Cambridge
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Why Is David C. Rubinsztein Influential?
(Suggest an Edit or Addition)According to Wikipedia, David Chaim Rubinsztein FRS FMedSci is the Deputy Director of the Cambridge Institute of Medical Research , Professor of Molecular Neurogenetics at the University of Cambridge and a UK Dementia Research Institute Professor.
David C. Rubinsztein's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease (2013) (3484)
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (3106)
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease (2004) (2367)
- Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes (2008) (2360)
- TFEB Links Autophagy to Lysosomal Biogenesis (2011) (2323)
- Autophagy and Aging (2011) (1807)
- Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease (2011) (1701)
- Regulation of mammalian autophagy in physiology and pathophysiology. (2010) (1656)
- Letter abstract - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's Disease (2009) (1644)
- The roles of intracellular protein-degradation pathways in neurodegeneration (2006) (1639)
- Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes (2009) (1441)
- Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (2013) (1388)
- Analysis of shared heritability in common disorders of the brain (2016) (1385)
- α-Synuclein Is Degraded by Both Autophagy and the Proteasome* (2003) (1376)
- Autophagy modulation as a potential therapeutic target for diverse diseases (2012) (1294)
- Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease (2014) (1230)
- Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. (2002) (1142)
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (1073)
- Molecular definitions of autophagy and related processes (2017) (1036)
- Potential therapeutic applications of autophagy (2007) (1006)
- Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein* (2007) (982)
- Autophagy in malignant transformation and cancer progression (2015) (941)
- Lithium induces autophagy by inhibiting inositol monophosphatase (2005) (932)
- Plasma membrane contributes to the formation of pre-autophagosomal structures (2010) (836)
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
- Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. (2008) (779)
- Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities (2017) (732)
- Lysosomal positioning coordinates cellular nutrient responses (2011) (724)
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease (2017) (693)
- Rapamycin alleviates toxicity of different aggregate-prone proteins. (2006) (656)
- Compromised autophagy and neurodegenerative diseases (2015) (637)
- Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates (2009) (615)
- α-Synuclein impairs macroautophagy: implications for Parkinson’s disease (2010) (599)
- Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language. (2000) (587)
- Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease (2010) (587)
- Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. (2007) (585)
- Transcriptional abnormalities in Huntington disease. (2003) (550)
- Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36-39 repeats. (1996) (538)
- A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). (2002) (522)
- In search of an “autophagomometer” (2009) (518)
- Mammalian Autophagy: How Does It Work? (2016) (514)
- Mechanisms of cross‐talk between the ubiquitin‐proteasome and autophagy‐lysosome systems (2010) (512)
- Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies (2009) (505)
- Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin. (2002) (505)
- A block of autophagy in lysosomal storage disorders. (2008) (500)
- Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair (2005) (454)
- Dynein mutations impair autophagic clearance of aggregate-prone proteins (2005) (440)
- Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? (2008) (439)
- Autophagy as a promoter of longevity: insights from model organisms (2018) (426)
- Apoptosis blocks Beclin 1-dependent autophagosome synthesis – an effect rescued by Bcl-xL (2009) (425)
- Rapamycin pre-treatment protects against apoptosis. (2006) (422)
- Control of autophagy as a therapy for neurodegenerative disease (2012) (415)
- Huntington's disease: from pathology and genetics to potential therapies. (2008) (411)
- The Itinerary of Autophagosomes: From Peripheral Formation to Kiss-and-Run Fusion with Lysosomes (2008) (409)
- Evidence for specific cognitive deficits in preclinical Huntington's disease. (1998) (406)
- Mechanisms of Autophagosome Biogenesis (2012) (401)
- Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease. (2000) (374)
- Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes (2013) (372)
- Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy (2014) (361)
- Autophagosome Precursor Maturation Requires Homotypic Fusion (2011) (352)
- Chemical modulators of autophagy as biological probes and potential therapeutics. (2011) (352)
- A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. (2008) (340)
- Microsatellite evolution — evidence for directionality and variation in rate between species (1995) (338)
- Complex Inhibitory Effects of Nitric Oxide on Autophagy (2011) (331)
- Palmitoylation of huntingtin by HIP14is essential for its trafficking and function (2006) (323)
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (323)
- Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease (2008) (310)
- Lessons from animal models of Huntington's disease. (2002) (304)
- The Poly(A)-Binding Protein Nuclear 1 Suppresses Alternative Cleavage and Polyadenylation Sites (2012) (302)
- Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications. (2006) (301)
- Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing (2018) (300)
- Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease. (2001) (293)
- Common variants at ABCA 7 , MS 4 A 6 A / MS 4 A 4 E , EPHA 1 , CD 33 and CD 2 AP are associated with Alzheimer ’ s disease (2011) (292)
- Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease. (2006) (283)
- Autophagy in major human diseases (2021) (282)
- Hydrophilic protein associated with desiccation tolerance exhibits broad protein stabilization function (2007) (282)
- Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection. (2011) (279)
- Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system (2013) (276)
- Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. (2007) (271)
- A comprehensive glossary of autophagy-related molecules and processes (2nd edition) (2011) (259)
- Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease. (1997) (259)
- Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3 (2009) (259)
- Polyglutamine tracts regulate beclin 1-dependent autophagy (2017) (257)
- A comprehensive glossary of autophagy-related molecules and processes (2010) (253)
- Cytoprotective roles for autophagy (2010) (239)
- Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species (2014) (237)
- Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease. (2000) (228)
- Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course. (2003) (222)
- Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases* (2010) (214)
- Microsatellites show mutational bias and heterozygote instability (1996) (206)
- Autophagy in healthy aging and disease (2021) (205)
- PICALM modulates autophagy activity and tau accumulation (2014) (205)
- Huntington’s disease: degradation of mutant huntingtin by autophagy (2008) (203)
- Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases (2005) (201)
- Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies. (2017) (199)
- PI(5)P Regulates Autophagosome Biogenesis (2015) (197)
- Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease (2010) (196)
- Glycogen Synthase Kinase-3β Inhibitors Prevent Cellular Polyglutamine Toxicity Caused by the Huntington's Disease Mutation* (2002) (195)
- Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy. (2006) (189)
- Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules (2012) (186)
- Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles. (2006) (185)
- Chemotherapy for the Brain: The Antitumor Antibiotic Mithramycin Prolongs Survival in a Mouse Model of Huntington's Disease (2004) (185)
- Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity (2005) (182)
- Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases. (2004) (181)
- Mammalian macroautophagy at a glance (2009) (181)
- Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. (2010) (179)
- Lysosomal storage diseases as disorders of autophagy (2008) (177)
- LC3-positive structures are prominent in autophagy-deficient cells (2019) (176)
- Therapeutic targeting of autophagy in neurodegenerative and infectious diseases (2015) (175)
- Convergent genetic and expression data implicate immunity in Alzheimer's disease (2014) (172)
- Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice (2010) (171)
- Laforin, the most common protein mutated in Lafora disease, regulates autophagy (2010) (171)
- Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease. (2005) (168)
- Apolipoprotein E Genetic Variation and Alzheimer’s Disease (1999) (164)
- Loss of PINK1 Function Affects Development and Results in Neurodegeneration in Zebrafish (2008) (162)
- Autophagy, a guardian against neurodegeneration (2010) (162)
- Transcriptional regulation of mammalian autophagy at a glance (2016) (159)
- Small Molecule Enhancers of Rapamycin-Induced TOR Inhibition Promote Autophagy, Reduce Toxicity in Huntington’s Disease Models and Enhance Killing of Mycobacteria by Macrophages (2007) (153)
- Inositol and IP3 Levels Regulate Autophagy—Biology and Therapeutic Speculations (2006) (152)
- Small molecule enhancers of autophagy for neurodegenerative diseases. (2008) (150)
- Chylomicron remnant clearance from the plasma is normal in familial hypercholesterolemic homozygotes with defined receptor defects. (1990) (148)
- The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway (2016) (148)
- Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease (2010) (148)
- Mutational bias provides a model for the evolution of Huntington's disease and predicts a general increase in disease prevalence (1994) (146)
- Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia (2015) (145)
- Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis (2018) (145)
- A molecular investigation of true dominance in Huntington’s disease (1999) (143)
- Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis (2016) (142)
- Autophagy and neurodegeneration. (2012) (142)
- Mutation analysis of the spastin gene (SPG4) in patients with hereditary spastic paraparesis (2000) (140)
- Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice (2005) (137)
- Autophagy in neurodegeneration and development (2008) (133)
- Huntington's disease: molecular basis of neurodegeneration (2003) (132)
- Decreased cAMP Response Element-mediated Transcription (2004) (131)
- Atg5 and Bcl-2 provide novel insights into the interplay between apoptosis and autophagy (2007) (131)
- Four Components Describe Behavioral Symptoms in 1,120 Individuals with Late‐Onset Alzheimer's Disease (2006) (130)
- Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion (2014) (130)
- Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A (2019) (130)
- The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A (2018) (130)
- Analysis of the huntingtin gene reveals a trinucleotide-length polymorphism in the region of the gene that contains two CCG-rich stretches and a correlation between decreased age of onset of Huntington's disease and CAG repeat number. (1993) (128)
- Protein misfolding disorders and macroautophagy (2011) (128)
- Connections between SNAREs and autophagy. (2013) (127)
- Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation (2018) (125)
- The molecular biology of Huntington's disease (2001) (125)
- Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly (2014) (124)
- Apathy and hypersomnia are common features of myotonic dystrophy (1998) (124)
- A novel link between autophagy and the ubiquitin-proteasome system (2009) (124)
- The ACE gene and Alzheimer's disease susceptibility (2000) (124)
- Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans. (1995) (123)
- Autophagy and misfolded proteins in neurodegeneration (2012) (121)
- DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. (2006) (121)
- Consensus Paper: Pathological Mechanisms Underlying Neurodegeneration in Spinocerebellar Ataxias (2014) (120)
- Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. (2003) (120)
- Wild type huntingtin reduces the cellular toxicity of mutant huntingtin in mammalian cell models of Huntington's disease (2001) (115)
- Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis (2018) (114)
- Mutant huntingtin represses CBP, but not p300, by binding and protein degradation (2005) (112)
- Autophagy induction as a therapeutic strategy for neurodegenerative diseases. (2019) (112)
- Mammalian, Yeast, Bacterial, and Chemical Chaperones Reduce Aggregate Formation and Death in a Cell Model of Oculopharyngeal Muscular Dystrophy* (2002) (112)
- Modulation of polyglutamine-induced cell death by genes identified by expression profiling. (2002) (110)
- Regulation of autophagy by lysosomal positioning (2011) (109)
- Expression and Characterization of Full-length Human Huntingtin, an Elongated HEAT Repeat Protein* (2006) (106)
- Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity (2010) (104)
- Network analysis of human Y microsatellite haplotypes. (1996) (103)
- Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex (2011) (102)
- The Hedgehog signalling pathway regulates autophagy (2012) (102)
- Autophagy impairment in Parkinson's disease. (2017) (101)
- Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin. (2007) (97)
- The role of membrane-trafficking small GTPases in the regulation of autophagy (2013) (95)
- Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity (2014) (95)
- α-Synuclein impairs macroautophagy: implications for Parkinson's disease (2010) (95)
- The Parkinson disease protein α-synuclein inhibits autophagy (2011) (95)
- A new locus for autosomal dominant "pure" hereditary spastic paraplegia mapping to chromosome 12q13, and evidence for further genetic heterogeneity. (1999) (92)
- Autophagic clearance of aggregate-prone proteins associated with neurodegeneration. (2009) (92)
- CCT complex restricts neuropathogenic protein aggregation via autophagy (2016) (88)
- Aberrant splicing in the presenilin-1 intron 4 mutation causes presenile Alzheimer's disease by increased Abeta42 secretion. (1999) (86)
- Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D (2012) (86)
- Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infections (2015) (86)
- Autophagy and polyglutamine diseases (2012) (85)
- Role of autophagy in the clearance of mutant huntingtin: a step towards therapy? (2006) (84)
- Apo E genotypes in multiple sclerosis, Parkinson's disease, schwannomas and late-onset Alzheimer's disease. (1994) (82)
- Comparative nuclear and mitochondrial genome diversity in humans and chimpanzees. (1997) (80)
- Alpha-synuclein overexpression promotes aggregation of mutant huntingtin. (2000) (80)
- Association of a functional polymorphism in the serotonin transporter gene with abnormal emotional processing in ecstasy users. (2005) (79)
- Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers (2001) (78)
- A presenilin-1 truncating mutation is present in two cases with autopsy-confirmed early-onset Alzheimer disease. (1998) (78)
- α-2 macroglobulin polymorphism and Alzheimer disease risk in the UK (1999) (77)
- Decreased BDNF Levels Are a Major Contributor to the Embryonic Phenotype of Huntingtin Knockdown Zebrafish (2009) (77)
- A locus for autosomal dominant "pure" hereditary spastic paraplegia maps to chromosome 19q13. (2000) (76)
- Analysis of spinocerebellar ataxia types 1, 2, 3, and 6, dentatorubral-pallidoluysian atrophy, and Friedreich's ataxia genes in spinocerebellar ataxia patients in the UK. (1997) (75)
- Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway. (2005) (74)
- Genetic association between monoamine oxidase A microsatellite and RFLP alleles and bipolar affective disorder: analysis and meta-analysis. (1996) (74)
- Biology and trafficking of ATG9 and ATG16L1, two proteins that regulate autophagosome formation (2013) (74)
- A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction (2017) (73)
- Can autophagy protect against neurodegeneration caused by aggregate-prone proteins? (2004) (72)
- Molecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres. (2010) (72)
- Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing (2019) (71)
- Ascertainment bias cannot entirely account for human microsatellites being longer than their chimpanzee homologues. (1998) (70)
- Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport (2016) (70)
- Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy (2010) (69)
- ATG16L1 meets ATG9 in recycling endosomes (2013) (69)
- Therapeutic induction of autophagy to modulate neurodegenerative disease progression (2013) (68)
- IGF-1 receptor antagonism inhibits autophagy (2013) (67)
- Methodological considerations for assessing autophagy modulators: A study with calcium phosphate precipitates (2009) (67)
- BCL2L11/BIM (2013) (67)
- Sequence variation and size ranges of CAG repeats in the Machado-Joseph disease, spinocerebellar ataxia type 1 and androgen receptor genes. (1995) (65)
- Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (2009) (64)
- Microsatellites are subject to directional evolution (1996) (64)
- siRNA screen identifies QPCT as a druggable target for Huntington’s disease (2015) (63)
- Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors (2009) (62)
- Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy (2015) (61)
- The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias (2007) (61)
- Autophagic activity in neuronal cell death (2015) (61)
- The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. (2012) (61)
- Autophagy Induction Rescues Toxicity Mediated by Proteasome Inhibition (2007) (60)
- Dyneins, Autophagy, Aggregation and Neurodegeneration (2005) (60)
- Mild myotonic dystrophy is associated with memory impairment in the context of normal general intelligence. (1997) (58)
- Apolipoprotein E: a review of its roles in lipoprotein metabolism, neuronal growth and repair and as a risk factor for Alzheimer's disease (1995) (58)
- p21-activated kinase 1 promotes soluble mutant huntingtin self-interaction and enhances toxicity. (2008) (58)
- Congo red, doxycycline, and HSP70 overexpression reduce aggregate formation and cell death in cell models of oculopharyngeal muscular dystrophy (2004) (56)
- Serotonin Transporter Polymorphism Mediates Vulnerability to Loss of Incentive Motivation Following Acute Tryptophan Depletion (2006) (55)
- Shared genetic contribution to ischemic stroke and Alzheimer's disease (2016) (55)
- The ACE I allele is associated with increased risk for ruptured intracranial aneurysms (2000) (54)
- Intracellular green fluorescent protein-polyalanine aggregates are associated with cell death. (2000) (54)
- Leucine regulates autophagy via acetylation of the mTORC1 component raptor (2020) (54)
- The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity (2011) (53)
- Intracellular inclusions, pathological markers in diseases caused by expanded polyglutamine tracts? (1999) (53)
- Clearance of mutant aggregate-prone proteins by autophagy. (2008) (52)
- Mammalian autophagy and the plasma membrane (2017) (52)
- Serotonin Transporter Polymorphism Mediates Vulnerability to Loss of Incentive Motivation Following Acute Tryptophan Depletion (2006) (51)
- Annual Review of Genomics and Human Genetics (2001) (51)
- cDNA cloning of a human homologue of the Caenorhabditis elegans cell fate-determining gene mab-21: expression, chromosomal localization and analysis of a highly polymorphic (CAG)n trinucleotide repeat. (1996) (51)
- Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia (2012) (51)
- Plasma membrane helps autophagosomes grow (2010) (51)
- The different autophagy degradation pathways and neurodegeneration (2022) (50)
- Myc inhibition impairs autophagosome formation (2013) (50)
- The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease (2001) (50)
- Protective Roles for Induction of Autophagy in Multiple Proteinopathies (2006) (50)
- Polyalanine and polyserine frameshift products in Huntington’s disease (2006) (49)
- A rare coding variant within the wolframin gene in bipolar and unipolar affective disorder cases (1999) (48)
- Measurement of Autophagic Activity in Mammalian Cells (2012) (47)
- Analysis of polyglutamine-coding repeats in the TATA-binding protein in different human populations and in patients with schizophrenia and bipolar affective disorder. (1996) (46)
- XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NFκB activation (2015) (46)
- Huntingtin promotes cell survival by preventing Pak2 cleavage (2009) (44)
- Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study (2005) (43)
- Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. (2008) (43)
- Spinocerebellar ataxias caused by polyglutamine expansions: A review of therapeutic strategies (2008) (43)
- Wild-type PABPN1 is anti-apoptotic and reduces toxicity of the oculopharyngeal muscular dystrophy mutation. (2008) (43)
- Autophagy, Cellular Aging and Age-related Human Diseases (2019) (43)
- Cystamine Suppresses Polyalanine Toxicity in a Mouse Model of Oculopharyngeal Muscular Dystrophy (2010) (42)
- Haplotype analysis of the delta 2642 and (CAG)n polymorphisms in the Huntington's disease (HD) gene provides an explanation for an apparent 'founder' HD haplotype. (1995) (42)
- Autophagy in Neuronal Development and Plasticity (2020) (38)
- Monogenic primary hypercholesterolaemia in South Africa. (1994) (38)
- Autophagy and mammalian development. (2013) (38)
- cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases (2020) (38)
- Analysis of Triplet Repeat Disorders (1998) (37)
- α-Synuclein levels modulate Huntington's disease in mice. (2012) (37)
- VCP/p97 regulates Beclin-1-dependent autophagy initiation (2021) (37)
- Markov chain Monte Carlo analysis of human Y-chromosome microsatellites provides evidence of biased mutation. (1999) (37)
- Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion. (2006) (36)
- The plasma membrane as a control center for autophagy (2012) (36)
- Microsatellites evolve more rapidly in humans than in chimpanzees. (1995) (36)
- Education, occupation and retirement age effects on the age of onset of Alzheimer's disease (2009) (36)
- Apo E genotypes and risk of dementia in Down syndrome. (1999) (36)
- Microsatellite and trinucleotide-repeat evolution: evidence for mutational bias and different rates of evolution in different lineages. (1999) (35)
- Site of (CCG) polymorphism in the HD gene (1993) (35)
- Functional analysis of the Huntington's disease (HD) gene promoter. (1998) (35)
- An Empirical Exploration of the (Δμ)2 Genetic Distance for 213 Human Microsatellite Markers (1999) (34)
- Subclinical cognitive impairment in autosomal dominant “pure” hereditary spastic paraplegia (1999) (33)
- Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
- Patients with features similar to Huntington's disease, without CAG expansion in huntingtin (1998) (32)
- Pathology of early-onset Alzheimer's disease cases bearing the Thr113-114ins presenilin-1 mutation. (2000) (32)
- Presenilin-1 intron 8 polymorphism is not associated with autopsy-confirmed late-onset Alzheimer's disease (1997) (32)
- Oculopharyngeal muscular dystrophy: potential therapies for an aggregate-associated disorder. (2006) (32)
- Impaired autophagy in Lafora disease (2010) (31)
- Decreased cAMP Response Element-mediated Transcription AN EARLY EVENT IN EXON 1 AND FULL-LENGTH CELL MODELS OF HUNTINGTON (cid:1) S DISEASE THAT CONTRIBUTES TO POLYGLUTAMINE PATHOGENESIS* (2004) (31)
- Zebrafish as a model to understand autophagy and its role in neurological disease☆ (2011) (31)
- Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease (2005) (31)
- Seeing is believing: methods to monitor vertebrate autophagy in vivo (2018) (30)
- A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo (2018) (30)
- Rapamycin induces autophagic flux in neurons (2010) (30)
- Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation (2012) (30)
- Locus-phenotype correlations in autosomal dominant pure hereditary spastic paraplegia. A clinical and molecular genetic study of 28 United Kingdom families. (1999) (29)
- Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease. (2004) (28)
- The genetics of Alzheimer's disease (1997) (28)
- Over-expression of BCL2 rescues muscle weakness in a mouse model of oculopharyngeal muscular dystrophy (2011) (27)
- Myotonic dystrophy CTG repeats and the associated insertion/deletion polymorphism in human and primate populations. (1994) (27)
- Characterization of six patients who are double heterozygotes for familial hypercholesterolemia and familial defective apo B-100. (1993) (27)
- Broadening the therapeutic scope for rapamycin treatment (2010) (27)
- How does the Huntington's disease mutation damage cells? (2003) (26)
- Analysis of thirteen trinucleotide repeat loci as candidate genes for schizophrenia and bipolar affective disorder. (1996) (26)
- Candidate gene association studies of the α4 (CHRNA4) and β2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease (2004) (26)
- Identification and properties of the proline664-leucine mutant LDL receptor in South Africans of Indian origin. (1992) (26)
- Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (26)
- Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells (2015) (26)
- Enrichment of fetal nucleated cells from maternal blood: Model test system using cord blood (1995) (25)
- Two novel point mutations causing receptor-negative familial hypercholesterolemia in a South African Indian homozygote. (1996) (25)
- BCL 2 L 11 / BIM A novel molecular link between autophagy and apoptosis (2012) (25)
- 1-O-Hexadecyl-2-O-methyl-3-O-(2'-acetamido-2'-deoxy-∃-D-glucopyranosyl)-sn-glycerol (Gln) induces cell death with more autophagosomes which is autophagy-independent (2009) (24)
- Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury (2018) (24)
- Study of the Huntington's disease (HD) gene CAG repeats in schizophrenic patients shows overlap of the normal and HD affected ranges but absence of correlation with schizophrenia. (1994) (24)
- No evidence for an association between Saitohin Q7R polymorphism and Alzheimer's disease (2002) (24)
- Non-Mendelian transmission at the Machado-Joseph disease locus in normal females: preferential transmission of alleles with smaller CAG repeats. (1997) (23)
- A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy. (2020) (23)
- Polyglutamine tracts regulate autophagy (2017) (23)
- Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner. (2021) (22)
- Mendelian neurodegenerative disease genes involved in autophagy (2020) (22)
- Developing Therapies for Neurodegenerative Disorders: Insights from Protein Aggregation and Cellular Stress Responses. (2020) (21)
- Analysis of the 5' upstream sequence of the Huntington's disease (HD) gene shows six new rare alleles which are unrelated to the age at onset of HD. (1997) (21)
- Phagophores evolve from recycling endosomes (2018) (20)
- Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy (2019) (20)
- Mutant huntingtin represses CBP, but not p300, by binding and protein degradation. (2005) (20)
- New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells (2019) (20)
- α-synuclein levels affect autophagosome numbers in vivo and modulate Huntington disease pathology (2012) (20)
- An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington’s disease (2017) (20)
- Genetic association of anLBP-1c/CP2/LSFgene polymorphism with late onset Alzheimer's disease (2001) (20)
- VPS35 Parkinson mutation impairs autophagy via WASH (2014) (20)
- LC3-II Tagging and Western Blotting for Monitoring Autophagic Activity in Mammalian Cells. (2016) (20)
- NeuroGeM, a knowledgebase of genetic modifiers in neurodegenerative diseases (2013) (19)
- Genetic association of an LBP-1c / CP2 / LSF gene polymorphism with late onset Alzheimer’s disease (2001) (19)
- Statin therapy in a kindred with both apolipoprotein B and low density lipoprotein receptor gene defects. (1997) (18)
- No evidence that extended tracts of homozygosity are associated with Alzheimer's disease (2011) (18)
- Cell biology: Receptors for selective recycling (2015) (18)
- Breakthroughs and bottlenecks in autophagy research. (2021) (18)
- Autophagy: where next? (2010) (17)
- Diminishing return for mechanistic therapeutics with neurodegenerative disease duration? (2016) (17)
- Identification of two new LDL-receptor mutations causing homozygous familial hypercholesterolemia in a South African of Indian origin. (1993) (17)
- Huntingtin-lowering strategies for Huntington’s disease (2020) (16)
- α Pix enhances mutant huntingtin aggregation (2010) (16)
- Genetic enhancement of macroautophagy in vertebrate models of neurodegenerative diseases (2019) (16)
- A30 Identification of MOAG-4/SERF as a regulator of age related proteotoxicity (2010) (16)
- Autophagy regulation by acetylation—implications for neurodegenerative diseases (2021) (16)
- Autophagy—alias self‐eating—appetite and ageing (2012) (15)
- Molecular Biology of Huntington's Disease (HD) and HD-Like Disorders (2003) (15)
- ULK1‐mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant (2019) (15)
- A 3-basepair deletion in repeat 1 of the LDL receptor promoter reduces transcriptional activity in a South African Pedi. (1998) (14)
- Latest advances in aging research and drug discovery (2019) (14)
- RIPK1 promotes inflammation and β-amyloid accumulation in Alzheimer’s disease (2017) (13)
- α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation (2021) (13)
- A genetic modifier suggests that endurance exercise exacerbates Huntington's disease (2018) (13)
- B37 repeats are normal in most schizophrenic patients (1994) (12)
- The pleiotropic roles of autophagy in Alzheimer's disease: From pathophysiology to therapy (2021) (12)
- ULK1-mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant. (2019) (12)
- Transbilayer phospholipid movement facilitates the translocation of annexin across membranes (2018) (12)
- Autophagy in ageing and ageing-related neurodegenerative diseases (2021) (12)
- Reducing Igf-1r Levels Leads To Paradoxical and Sexually Dimorphic Effects in HD Mice (2014) (11)
- Mendelian neurodegenerative disease genes involved in autophagy (2020) (11)
- The roles of the ubiquitin-proteasome and autophagy–lysosome pathways in Huntington's disease and related conditions (2003) (11)
- Publisher Correction: Autophagy as a promoter of longevity: insights from model organisms (2018) (11)
- Paradoxical aggregation versus oligomerisation properties of mutant and wild-type huntingtin fragments (2006) (11)
- Methods to analyze SNARE-dependent vesicular fusion events that regulate autophagosome biogenesis (2015) (10)
- Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (vol 41, pg 1088, 2009) (2013) (10)
- Functional genomics approaches to neurodegenerative diseases (2008) (10)
- Familial defective apolipoprotein-B is rare in hypercholesterolaemic South African Afrikaners, coloureds and Indians. (1995) (10)
- Protein-protein interaction networks in the spinocerebellar ataxias (2006) (9)
- From Genetics to Gene Therapy (1995) (9)
- The bacterial chaperonin GroEL requires GroES to reduce aggregation and cell death in a COS-7 cell model of Huntington's disease (2002) (9)
- Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people (2010) (9)
- mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR. (2020) (9)
- IFNB/interferon-β regulates autophagy via a MIR1-TBC1D15-RAB7 pathway (2020) (8)
- A Novel Atg 5-shRNA Mouse Model Enables Temporal Control of 1 Autophagy in vivo 2 3 (2017) (7)
- The EUROGEM map of human chromosome 10. (1994) (7)
- An empirical exploration of the (delta mu)2 genetic distance for 213 human microsatellite markers. (1999) (7)
- Absence of relationship between MTTP haplotypes and longevity. (2007) (7)
- Cdks regulate autophagy via Vps34. (2010) (6)
- Faculty Opinions recommendation of JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. (2008) (6)
- The Molecular Pathology of Huntington's Disease (HD) (2003) (6)
- Mirror image phosphoinositides regulate autophagy (2015) (6)
- Normal CAG and CCG repeats in the Huntington's disease genes of Parkinson's disease patients. (1995) (6)
- Coincidence detection of RAB11A and PI(3)P by WIPI2 directs autophagosome formation (2019) (5)
- Instability of normal (CTG)n alleles in the DM kinase gene. (1997) (5)
- The spastic paraplegia SPG10 locus: narrowing of critical region and exclusion of sodium channel gene SCN8A as a candidate (2001) (5)
- Correction to: Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation (2019) (5)
- Autophagy in childhood neurological disorders (2018) (5)
- The Molecular Pathology of Huntingtons Disease (HD) (2003) (5)
- Vinexin contributes to autophagic decline in brain ageing across species (2021) (5)
- Homozygotes and heterozygotes for ciliary neurotrophic factor null alleles do not show earlier onset of Huntington's disease (1997) (5)
- Plasma membrane contributes to the formation of pre-autophagosomal structures (2010) (4)
- It's time to eat yourself healthy: On signals controlling autophagy (2012) (4)
- Tau toxicity feeds forward in frontotemporal dementia (2016) (4)
- LC3-positive structures are prominent in autophagy-deficient cells (2019) (4)
- Autophagy Upregulation as a Therapeutic Strategy for Neurodegenerative Diseases (2013) (4)
- Issues in Huntington's disease testing. (1994) (4)
- Allelic variation in the promoter region of the LDL receptor gene: analysis of an African-specific variant in the FP2 cis-acting regulatory element. (2003) (3)
- 12‐O‐Tetradecanoyl‐phorbol‐13‐acetate down‐regulates the Huntingtin promoter at Spl sites (2000) (3)
- Macroautophagy without LC3 conjugation? (2016) (3)
- Transient siRNA-mediated protein knockdown in mouse followed by feeding/starving cycle and liver tissue analysis (2021) (3)
- Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations (2018) (3)
- The EUROGEM map of human chromosome X. (1994) (3)
- Trinucleotide repeat mutation processes (2020) (3)
- AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation (2021) (3)
- Deadly Encounter: Endosomes Meet Mitochondria to Initiate Apoptosis. (2020) (2)
- The complexity of biological control systems: An autophagy case study (2022) (2)
- VCP/p97 modulates PtdIns3P production and autophagy initiation (2021) (2)
- AMPK: the energy sensor that regulates autophagy and a potential therapeutic target for neurodegenerative diseases (2021) (2)
- Correction: Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease (2011) (2)
- Analysis of thirteen trinucleotide repeat loci as candidate genes for schizophrenia and bipolar disorder (1996) (2)
- Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance (2022) (2)
- Unravelling proteinopathies: an interview with David Rubinsztein (2015) (2)
- Author Correction: Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing (2019) (2)
- Phospholipid flipping facilitates annexin translocation across membranes (2018) (2)
- Huntington’s disease (2003) (2)
- Neurodegenerative Diseases and Autophagy (2018) (1)
- Faculty Opinions recommendation of Ambra1 regulates autophagy and development of the nervous system. (2007) (1)
- Increased SORBS3 expression in brain ageing contributes to autophagic decline via YAP1-WWTR1/TAZ signaling (2022) (1)
- A location, location, location mutation impairs DNM2-mediated release of nascent autophagosomes from recycling endosomes (2020) (1)
- A presenilin-1 truncating mutation causing Alzheimer's disease (1999) (1)
- How useful are animal models of human disease? (2003) (1)
- A New Zebrafish Model to Measure Neuronal α-Synuclein Clearance In Vivo (2022) (1)
- The EUROGEM map of human chromosome 9. (1994) (1)
- Nucleotide and protein expansions and human disease (2004) (1)
- Huntington's disease—the sting in the tail (2015) (1)
- Unexpected Phenotype Reversion and Survival in a Zebrafish Model of Multiple Sulfatase Deficiency (2022) (1)
- Autophagic activity in neuronal cell death (2015) (1)
- Autophagy researchers (2014) (1)
- Fluorescence-Based Assays to Analyse Phosphatidylinositol 5-Phosphate in Autophagy. (2017) (1)
- Autophagy in healthy ageing and disease (2021) (1)
- P1-014 Principal components analysis of the neuropsychiatric inventory in Alzheimer's disease (2004) (0)
- P1-327 Testing for association between Alzheimer’s disease with psychosis and functional gene candidates (2006) (0)
- P1-328 Association analysis of 22 positional/functional candidate genes on chromosome 10 with late onset Alzheimer’s disease (2006) (0)
- P1-219 Three components describe behavioural symptoms in 1120 individuals with late-onset Alzheimer’s disease (2006) (0)
- Author Correction: Mendelian neurodegenerative disease genes involved in autophagy (2020) (0)
- Genes and aging by M.S. Kanungo Cambridge University Press, 1994. £40.00/$69.95 (322 pages) ISBN 0 521 38299 8 (1995) (0)
- Genetic association between monoamine oxidase A microsatellite and RFLP alleles and bipolar affective disorder: analysis and meta-analysis. 1 in congenital heart disease using D22S75 probe Network of human Y microsatellite haplotypes (0)
- Effects of methylphenidate and/or sulpiride on working memory performance and interaction with COMT 158val/met polymorphism (2005) (0)
- Microsatellite and trinucleotide repeat expansion diseases (2020) (0)
- Molecular Mechanisms of Dementia (1997) (0)
- Author Correction: Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing (2019) (0)
- Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis (2018) (0)
- The extended quality control role of the ER‐anchored ubiquitin ligase Hrd1 in the targeting of expanded huntingtin for degradation (2007) (0)
- O2-02-05 Novel candidate genes for late-onset Alzheimer’s disease from a large scale association study of 20K functional variants (2006) (0)
- Author Correction: Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury (2021) (0)
- TMED9–SEC12, an important “contact” for autophagy (2021) (0)
- Publisher Correction: Autophagy as a promoter of longevity: insights from model organisms (2018) (0)
- P1-335 A powerful association analysis of 496 SNPs in 80 positional candidate genes in a linked region on chromosome 10 for association with late onset Alzheimer’s disease (2006) (0)
- Corrigendum (1990) (0)
- NeuroGeM, a knowledgebase of genetic modifiers in neurodegenerative diseases (2013) (0)
- Assessing Autophagic Activity and Aggregate Formation of Mutant Huntingtin in Mammalian Cells. (2018) (0)
- Faculty Opinions recommendation of Caspase activation precedes and leads to tangles. (2010) (0)
- Correction to: Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation (2019) (0)
- Author Correction: Mendelian neurodegenerative disease genes involved in autophagy (2020) (0)
- Vulnerability to loss of motivated action following acute tryptophan depletion: The role of allelic variation at the serotonin transporter gene (2005) (0)
- HR-LiP, a novel structural proteomics approach for the prediction of small molecule drug-protein binding events (2022) (0)
- Autophagy as a promoter of longevity: insights from model organisms (2018) (0)
- Programme (2013) (0)
- P3-265: Testing for association between Alzheimer's disease with psychosis and variants identified as influencing risk of schizophrenia (2008) (0)
- Faculty Opinions recommendation of A photoconvertible fluorescent reporter to track chaperone-mediated autophagy. (2011) (0)
- Investigating psychosis candidate genes in Alzheimer's disease with psychosis using genome-wide association studies (2009) (0)
- Corrigendum: PICALM modulates autophagy activity and tau accumulation (2015) (0)
- Leucine regulates autophagy via acetylation of the mTORC1 component raptor (2020) (0)
- Induction d'autophagie dépendante de l'amp cyclique (2008) (0)
- Lysosome positioning and mTOR activity in Lowe syndrome (2021) (0)
- Analysis ofthe5'upstreamsequenceofthe Huntington's disease (HD)geneshowssixnew rarealleles which areunrelated totheageatonset (1997) (0)
- α-Synuclein levels modulate Huntington's disease in mice (2012) (0)
- Understanding Genetics: A Molecular Approach (1994) (0)
- Chapter 2. Role of Academia: Drug Repurposing to Induce Autophagy for Treatment of Neurodegenerative Diseases (2022) (0)
- SPG4 (spastin) mutation screening in hereditary spastic paraparesis. (2001) (0)
- Protein homeostasis networks in physiology and disease (2011) (0)
- An inducible expression system for the manipulation of autophagic flux in vivo. (2022) (0)
- Autophagy and polyglutamine diseases Selective degradation of protein aggregates by autophagy. Progress in Neurobiology (2012) (0)
- Author Correction: Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury (2018) (0)
- Monogenic hypercholesterolemia in South Africans : familial hypercholesterolemia in Indians and familial defective apolipoprotein B-100 (1993) (0)
- Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration (2023) (0)
- SMER28 binding to VCP/p97 enhances both autophagic and proteasomal neurotoxic protein clearance (2022) (0)
- Measurement of Neuronal Clearance In Vivo (2021) (0)
- Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing (2019) (0)
- Mildmyotonic dystrophy isassociated with memory impairment inthecontextofnormal general intelligence J SRubinsztein, D C Rubinsztein, PJMcKenna, SGoodburn, AJHolland (1997) (0)
- P3-245: Association analysis of tau and progranulin with late-onset Alzheimer's disease in a large caucasian U.K. sample (2008) (0)
- O2-06-01: A powerful, genome-wide association scan for susceptibility genes for late-onset Alzheimer's disease (2008) (0)
- What's in a name? (2010) (0)
- The deleterious effect of polyglutamine aggregation in cell models of Huntington's disease. (2000) (0)
- Autophagy, Inflammation, and Metabolism (AIM) Center in its second year (2019) (0)
- TITLE Genes of the serotonergic and dopaminergic pathways and their interaction affect the expression of Behavioural and Psychological Symptoms in Dementia (BPSD): A Multiple Indicators Multiple Causes (MIMIC) approach. (2009) (0)
- Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis (2018) (0)
- kinase gene . Instability of normal ( CTG ) n alleles in the DM (2004) (0)
- Apoptotic cell death in disease—Current understanding of the NCCD 2023 (2023) (0)
- Faculty Opinions recommendation of Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes. (2011) (0)
- Decoding Darkness - The Search for the Genetic Causes of Alzheimer's Disease. (2001) (0)
- StudyoftheHuntington's disease (HD)gene CAG repeatsinschizophrenic patients shows overlap ofthenormalandHD affected ranges butabsence ofcorrelation withschizophrenia (1994) (0)
- Affective disturbance in currently abstinent MDMA (ecstasy) users (2003) (0)
- Post-translational modifications of Beclin 1 provide multiple strategies 1 for autophagy regulation 2 (2018) (0)
- Beth Levine in memoriam (2020) (0)
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (0)
- S.05.01 Basic mechanisms of autophagy and pharmacological induction (2017) (0)
- Protocol for determining the regulation of lipid kinases and changes in phospholipids in vitro (2021) (0)
- THE KINESIN LIGHT CHAIN 1 POLYMORPHISM rs 8702 IS ASSOCIATED WITH ELEVATED CSF LEVELS OF SECRETED FORMS OF AMYLOID PRECURSOR PROTEIN (2008) (0)
- Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation (2018) (0)
- THE POTENTIAL OF AUTOPHAGY REGULATION IN THE TREATMENT OF NEURODEGENERATIVE DISEASES (2012) (0)
- Autophagy in Pacific oyster, Crassostrea gigas (2014) (0)
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