David A. Hafler

Q: What Schools Are Affiliated With David A. Hafler

David A. Hafler is affiliated with the following schools: Yale University, Emory University, Massachusetts Institute of Technology, University of Pittsburgh, Kagawa University, University of Miami, Massachusetts General Hospital, Harvard University, University of Pennsylvania

David A. Hafler's AcademicInfluence.com Rankings

David A. Hafler

Medical

#777

World Rank

#1019

Historical Rank

#279

USA Rank

Neurology

#63

World Rank

#108

Historical Rank

#24

USA Rank

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Medical

David A. Hafler's Degrees

Doctorate Medicine University of Pennsylvania
PhD Immunology University of Pennsylvania

Why Is David A. Hafler Influential?

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According to Wikipedia, David A. Hafler is an American neurologist. He is the Edgerly Professor and chairman of the department of Neurology at the Yale School of Medicine. He is known for his work in immunity, genetics, and multiple sclerosis. In 2018 he was elected to the National Academy of Medicine.

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David A. Hafler's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis (2011) (2511)
FOXP3+ regulatory T cells in the human immune system (2010) (2170)
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. (1994) (2128)
Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis (2004) (1868)
CD4+CD25high Regulatory Cells in Human Peripheral Blood1 (2001) (1796)
Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants (2014) (1487)
Risk alleles for multiple sclerosis identified by a genomewide study. (2007) (1380)
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis (2013) (1170)
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells (2013) (1138)
Induction and molecular signature of pathogenic TH17 cells (2012) (956)
Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. (1994) (937)
T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis (1990) (915)
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci (2009) (799)
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC (2006) (764)
Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes (1998) (644)
Promotion of Tissue Inflammation by the Immune Receptor Tim-3 Expressed on Innate Immune Cells (2007) (622)
Effects of oral administration of type II collagen on rheumatoid arthritis. (1993) (620)
Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. (2014) (606)
IL-21 and TGF-β are required for differentiation of human TH17 cells (2008) (602)
Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. (1993) (598)
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis (2007) (592)
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility (2019) (589)
Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis (1994) (559)
Pervasive Sharing of Genetic Effects in Autoimmune Disease (2011) (537)
Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. (1996) (513)
IL-17-producing human peripheral regulatory T cells retain suppressive function. (2009) (501)
Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions (1995) (486)
Methods for high-density admixture mapping of disease genes. (2004) (477)
Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis (2003) (473)
Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes (2014) (466)
Protective and therapeutic role for αB-crystallin in autoimmune demyelination (2007) (459)
A high-density admixture map for disease gene discovery in african americans. (2004) (450)
Automated high-dimensional flow cytometric data analysis (2009) (434)
Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease (2011) (433)
Human CD4+CD25+ regulatory T cells. (2004) (431)
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope (2005) (428)
Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. (1990) (407)
Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. (2000) (406)
De Novo Copy Number Variants Identify New Genes and Loci in Isolated, Sporadic Tetralogy of Fallot (2009) (403)
Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells (2014) (383)
B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes (2014) (378)
Regulatory T cells in autoimmune disease (2018) (374)
Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones (1994) (345)
The TIGIT/CD226 Axis Regulates Human T Cell Function (2012) (337)
Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. (1997) (332)
Role of “Western Diet” in Inflammatory Autoimmune Diseases (2013) (326)
In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. (1985) (324)
pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires (2014) (322)
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein (2007) (321)
Seminars in medicine of the Beth Israel Hospital, Boston. Pathogenesis of diseases induced by human lymphotropic virus type I infection. (1993) (320)
The plasticity of human Treg and Th17 cells and its role in autoimmunity. (2013) (315)
A high-density screen for linkage in multiple sclerosis. (2005) (308)
TIM‐3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines (2009) (308)
Prospects of immune checkpoint modulators in the treatment of glioblastoma (2015) (301)
Inhibition of Human CD4+CD25+high Regulatory T Cell Function1 (2002) (298)
MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination. (1993) (296)
Fingolimod for multiple sclerosis. (2012) (283)
Polyfunctional responses by human T cells result from sequential release of cytokines (2011) (281)
Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. (2006) (281)
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility (2005) (271)
Human regulatory T cells and their role in autoimmune disease (2006) (265)
Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions. (1992) (265)
Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score (2009) (264)
Class II HLA interactions modulate genetic risk for multiple sclerosis (2015) (262)
Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2. (2009) (260)
Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. (1995) (259)
Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. (1994) (258)
MS: a CNS and systemic autoimmune disease. (1989) (258)
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases (2009) (256)
Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody. (1987) (254)
MHC Class II Expression Identifies Functionally Distinct Human Regulatory T Cells1 (2006) (252)
Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects (2013) (252)
Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. (2015) (252)
Multiple sclerosis—a quiet revolution (2015) (252)
Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. (2009) (252)
Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Proinflammatory Cytokines Inducing Th17 Cells1 (2009) (250)
Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. (2014) (249)
IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production (2009) (244)
Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis (1993) (243)
An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. (2004) (243)
Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis (2015) (238)
From Big Data to Precision Medicine (2019) (238)
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. (2010) (236)
Dysregulated T cell expression of TIM3 in multiple sclerosis (2006) (231)
T Cell Ig- and Mucin-Domain-Containing Molecule-3 (TIM-3) and TIM-1 Molecules Are Differentially Expressed on Human Th1 and Th2 Cells and in Cerebrospinal Fluid-Derived Mononuclear Cells in Multiple Sclerosis1 (2004) (229)
Genetic Analysis of Human Traits In Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell Lines (2008) (215)
Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. (1998) (215)
Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. (1998) (209)
Polyspecificity of T cell and B cell receptor recognition. (2007) (205)
The role of the CD58 locus in multiple sclerosis (2009) (200)
GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. (2002) (196)
Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. (2007) (195)
Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid (2009) (188)
Regulatory T cells in autoimmune neuroinflammation (2014) (184)
A second major histocompatibility complex susceptibility locus for multiple sclerosis (2007) (181)
The Neuroimmunology of Multiple Sclerosis: Possible Roles of T and B Lymphocytes in Immunopathogenesis (2001) (175)
Models of Somatic Hypermutation Targeting and Substitution Based on Synonymous Mutations from High-Throughput Immunoglobulin Sequencing Data (2013) (174)
Antibodies from Inflamed Central Nervous System Tissue Recognize Myelin Oligodendrocyte Glycoprotein1 (2005) (174)
Enhanced suppressor function of TIM‐3+FoxP3+ regulatory T cells (2014) (172)
Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. (2010) (171)
Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis. (2011) (170)
PD-1 marks dysfunctional regulatory T cells in malignant gliomas. (2016) (169)
Suppressor T Cells in Human Diseases (2004) (167)
TGF-β Induces IL-9 Production from Human Th17 Cells (2010) (167)
Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells. (2005) (165)
Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers. (2000) (163)
Multiple Sclerosis and Regulatory T Cells (2008) (163)
Innate Immunity in Multiple Sclerosis: Myeloid Dendritic Cells in Secondary Progressive Multiple Sclerosis Are Activated and Drive a Proinflammatory Immune Response1 (2006) (162)
Immunologic Mechanisms and Therapy in Multiple Sclerosis (1995) (159)
Human regulatory T cells and autoimmunity (2008) (159)
Functionally defective germline variants of sialic acid acetylesterase in autoimmunity (2010) (158)
CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production. (1992) (157)
The expanding genetic overlap between multiple sclerosis and type I diabetes (2009) (157)
The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases (2007) (155)
Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial. (1997) (154)
Microbial Reprogramming Inhibits Western Diet-Associated Obesity (2013) (153)
T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions (1992) (151)
Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls. (2013) (149)
CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. (2003) (148)
Early signaling defects in human T cells anergized by T cell presentation of autoantigen (1992) (145)
Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody (1988) (143)
Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy. (1999) (142)
IL-12 induces human T cells secreting IL-10 with IFN-gamma. (1996) (141)
Age-Dependent B Cell Autoimmunity to a Myelin Surface Antigen in Pediatric Multiple Sclerosis1 (2009) (140)
Soluble IL-2RA Levels in Multiple Sclerosis Subjects and the Effect of Soluble IL-2RA on Immune Responses1 (2009) (137)
Immunological Memory: Contribution of Memory B Cells Expressing Costimulatory Molecules in the Resting State1 (2001) (136)
T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans (1994) (136)
Specific peripheral B cell tolerance defects in patients with multiple sclerosis. (2013) (134)
Multiple sclerosis. (2012) (134)
Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis [published erratum appears in J Exp Med 1988 Jul 1;168(1):459] (1988) (129)
Integrating risk factors (2008) (129)
T-cell recognition of myelin basic protein. (1991) (128)
A Local Antigen-Driven Humoral Response Is Present in the Inflammatory Myopathies1 (2007) (127)
Molecular pathogenesis of multiple sclerosis (1999) (127)
Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. (1995) (126)
Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells. (1998) (125)
Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis (1986) (125)
Lack of TIM-3 Immunoregulation in Multiple Sclerosis1 (2008) (124)
Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin (2011) (124)
Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor (2009) (123)
TGF-&bgr;1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage (2016) (119)
Regulatory T cells in the central nervous system (2012) (119)
Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis. (1987) (117)
TIM-4 Expressed on APCs Induces T Cell Expansion and Survival1 (2008) (116)
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children (2021) (115)
Molecular Mimicry in Lyme Arthritis Demonstrated at the Single Cell Level: LFA-1αL Is a Partial Agonist for Outer Surface Protein A-Reactive T Cells1 (2001) (115)
TCR usage in human and experimental demyelinating disease. (1996) (115)
The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility (2017) (113)
Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements. (1995) (113)
Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine. (2011) (112)
Multiple differences in gene expression in regulatory Vα24JαQ T cells from identical twins discordant for type I diabetes (2000) (111)
Direct Ex Vivo Analysis of Activated, Fas-sensitive Autoreactive T Cells in Human Autoimmune Disease (1997) (110)
Antigen-specific therapy for autoimmune disease. (2000) (110)
Biomarkers in multiple sclerosis. (2015) (109)
Refining genetic associations in multiple sclerosis (2008) (108)
Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci (2009) (107)
T Cells in Multiple Sclerosis and Inflammatory Central Nervous System Diseases (1987) (107)
TLR‐mediated STAT3 and ERK activation controls IL‐10 secretion by human B cells (2014) (106)
Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responses (2017) (105)
T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. (1992) (103)
Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions (2003) (100)
Immune-mediated disease genetics: the shared basis of pathogenesis. (2013) (99)
Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk (2018) (98)
Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection. (1998) (98)
Immunotherapy of multiple sclerosis (1988) (96)
B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors. (1997) (91)
TLR7 induces anergy in human CD4+ T cells (2014) (91)
CD4CD25 Regulatory Cells in Human Peripheral Blood (2001) (90)
Antigen reactive memory T cells are defined by Ta1. (1986) (90)
Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses. (1988) (87)
In vivo labeling of blood T cells: Rapid traffic into cerebrospinal fluid in multiple sclerosis (1987) (87)
Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. (2004) (86)
The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+ T Cell Proliferation (2011) (86)
Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population (2000) (86)
CTLA4 is associated with susceptibility to multiple sclerosis (2003) (86)
Natural killer activating receptors trigger interferon gamma secretion from T cells and natural killer cells. (1998) (85)
Human regulatory T cells in autoimmune diseases. (2010) (84)
Abnormal Tr1 differentiation in multiple sclerosis (2007) (83)
OR.41. IL-21 and TGF-β are Required for Differentiation of Human Th17 Cells (2008) (83)
The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions. (1988) (83)
Monoclonal gammopathy and neuropathy (1986) (82)
PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. (2004) (82)
Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: Increased interleukin‐4 production and associated eosinophilia (1997) (82)
Multiple sclerosis. (2004) (82)
T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects. (1999) (82)
Functional three-domain single-chain T-cell receptors. (1994) (81)
Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells. (2008) (81)
The CD226/CD155 Interaction Regulates the Proinflammatory (Th1/Th17)/Anti-Inflammatory (Th2) Balance in Humans (2013) (81)
The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis. (1999) (80)
Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis (1998) (80)
Presentation of autoantigen by human T cells. (1991) (80)
The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system. (1999) (79)
Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease. (1991) (78)
High Incidence of Spontaneous Disease in an HLA-DR15 and TCR Transgenic Multiple Sclerosis Model1 (2005) (77)
Oral Administration of Myelin Induces Antigen‐specific TGF‐β1 Secreting T Cells in Patients with Multiple Sclerosis a (1997) (77)
Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands. (1997) (77)
Examination of CD8+ T Cell Function in Humans Using MHC Class I Tetramers: Similar Cytotoxicity but Variable Proliferation and Cytokine Production Among Different Clonal CD8+ T Cells Specific to a Single Viral Epitope (2000) (76)
Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli (2015) (75)
Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4 + 2H4 +) T Cells in multiple sclerosis (1988) (74)
Immunologic responses of progressive multiple sclerosis patients treated with an anti‐T‐cell monoclonal antibody, anti‐T12 (1986) (74)
Increased Frequencies of Myelin Oligodendrocyte Glycoprotein/MHC Class II-Binding CD4 Cells in Patients with Multiple Sclerosis (2011) (74)
Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones. (1996) (73)
PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. (2013) (73)
Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV. (2018) (72)
IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci (2010) (72)
Phosphorylation of CD4 and CD8 molecules following T cell triggering. (1987) (72)
Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. (2008) (71)
Allelic variant in CTLA4 alters T cell phosphorylation patterns (2007) (71)
Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin antigens: IV. Suppression of chronic relapsing disease in the lewis rat and strain 13 guinea pig (1991) (71)
Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain (2022) (71)
Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility (2010) (70)
Treatment of progressive multiple sclerosis with pulse cyclophosphamidel methylprednisolone: Response to therapy is linked to the duration of progressive disease (1999) (69)
CTLA4Ig treatment in patients with multiple sclerosis (2008) (69)
Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4. (1997) (69)
TIMs: central regulators of immune responses (2008) (69)
Loss of IL-4 Secretion from Human Type 1a Diabetic Pancreatic Draining Lymph Node NKT Cells (2005) (68)
Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data (2011) (66)
Multiple sclerosis: genetics, biomarkers, treatments. (2016) (66)
Spinal subarachnoid hematoma: a hazard of lumbar puncture resulting in reversible paraplegia. (1981) (66)
Variable immortalizing potential and frequent virus latency in blood-derived T-cell clones infected with human T-cell leukemia virus type I. (1997) (66)
Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. (1992) (65)
TIGIT signaling restores suppressor function of Th1 Tregs. (2019) (65)
Activated β-Catenin in Foxp3+ Regulatory T cells Links Inflammatory Environments to Autoimmunity (2018) (65)
Preliminary safety and activity of nivolumab and its combination with ipilimumab in recurrent glioblastoma (GBM): CHECKMATE-143. (2015) (64)
The Genetic Association of Variants in CD6, TNFRSF1A and IRF8 to Multiple Sclerosis: A Multicenter Case-Control Study (2011) (64)
Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis (2008) (64)
Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand. (1995) (63)
Multiple sclerosis—a quiet revolution (2015) (63)
Induction of anergy in CD8 T cells by B cell presentation of antigen. (1996) (63)
Decrease of suppressor inducer (cd4+ 2h4+) t cells in multiple sclerosis cerebrospinal fluid (1989) (63)
AKT isoforms modulate Th1‐like Treg generation and function in human autoimmune disease (2016) (62)
Common T‐cell receptor Vβ usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis (1991) (62)
An RNA Profile Identifies Two Subsets of Multiple Sclerosis Patients Differing in Disease Activity (2012) (60)
CNS demyelination and enhanced myelin-reactive responses after ipilimumab treatment (2016) (60)
Human and Murine CD4 T Cell Reactivity to a Complex Antigen: Recognition of the Synthetic Random Polypeptide Glatiramer Acetate1 (2000) (59)
Human T-cell lymphotropic virus type I (1996) (59)
Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity (1997) (59)
T cell vaccination in multiple sclerosis: a preliminary report. (1992) (59)
Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99. (1997) (58)
Genetic basis of autoimmunity. (2015) (58)
A Major Histocompatibility Class I Locus Contributes to Multiple Sclerosis Susceptibility Independently from HLA-DRB1*15:01 (2010) (56)
Genetic analysis of multiple sclerosis. (2003) (56)
Lymphokine regulation of CD45R expression on human T cell clones (1989) (56)
Unraveling the autoimmune translational research process layer by layer (2012) (55)
Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. (2015) (54)
Transcriptomic and clonal characterization of T cells in the human central nervous system (2020) (54)
Decreased autologous mixed lymphocyte reaction in multiple sclerosis (1985) (53)
Disease‐related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis (2004) (53)
Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes. (1995) (53)
T-cells in multiple sclerosis. (2010) (52)
Decreases in Interleukin-4 Secretion by Invariant CD4−CD8−Vα24JαQ T Cells in Peripheral Blood of Patients with Relapsing–Remitting Multiple Sclerosis (2001) (52)
Enhanced B7 costimulatory molecule expression in inflammatory human sural nerve biopsies (2000) (52)
FcR-mediated crosslinking of Ta1 (CDw26) induces human T lymphocyte activation. (1990) (51)
New therapeutic approaches for multiple sclerosis. (2007) (51)
T‐T cell interactions are mediated by adhesion molecules (1990) (50)
CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. (2010) (50)
Mechanisms of immune memory. T cell activation and CD3 phosphorylation correlates with Ta1 (CDw26) expression. (1989) (49)
Autoreactive T cells in multiple sclerosis. (1992) (49)
Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex. (2011) (49)
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19 (2020) (49)
National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness: Building on the Current Scientific Evidence. (2016) (49)
Joint Modeling and Registration of Cell Populations in Cohorts of High-Dimensional Flow Cytometric Data (2013) (49)
Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing– remitting multiple sclerosis (2013) (49)
Phenotypic and functional analysis of T cells cloned directly from the blood and cerebrospinal fluid of patients with multiple sclerosis (1985) (48)
CD2 Costimulation Reveals Defective Activity by Human CD4+CD25hi Regulatory Cells in Patients with Multiple Sclerosis (2011) (48)
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19 (2022) (48)
TGF- β 1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage (2016) (47)
Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis (1998) (46)
Cyclophosphamide and plasma exchange in multiple sclerosis (1991) (46)
Ubiquitous pathogens (2000) (46)
Altered blood T-cell subsets in patients with multiple sclerosis (1984) (45)
T cell anergy (1994) (45)
Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis (2006) (44)
Rapamycin-resistant Proliferation of CD8+ T Cells Correlates with p27kip1 Down-regulation and bcl-xL Induction, and Is Prevented by an Inhibitor of Phosphoinositide 3-Kinase Activity* (2004) (43)
Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression. (1994) (43)
Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases. (1985) (43)
Regulatory T Cells: From Discovery to Autoimmunity. (2018) (43)
Regional specificity of HTLV-I proviral integration in the human genome. (1994) (42)
PCR Analysis of DNA from Multiple Sclerosis Patients for the Presence of HTLV-I (1989) (42)
Autoimmunity risk alleles in costimulation pathways (2009) (41)
IL 12 A , MPHOSPH 9 / CDK 2 AP 1 and RGS 1 are novel multiple sclerosis susceptibility loci (2010) (41)
Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells (1993) (40)
A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis. (2010) (40)
Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseases (1991) (39)
Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization (2018) (39)
Multiple sclerosis. (2005) (39)
Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells (2016) (39)
Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis (2017) (38)
Variation within DNA repair pathway genes and risk of multiple sclerosis. (2010) (38)
Cross-Reactive TCR Responses to Self Antigens Presented by Different MHC Class II Molecules (2004) (38)
Uncoupling p70s6 Kinase Activation and Proliferation: Rapamycin-Resistant Proliferation of Human CD8+ T Lymphocytes1 (2001) (38)
Population structure and HLA DRB1*1501 in the response of subjects with multiple sclerosis to first-line treatments (2011) (38)
On-chip activation and subsequent detection of individual antigen-specific T cells. (2009) (37)
Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes. (2000) (37)
Degeneracy, as opposed to specificity, in immunotherapy. (2002) (37)
Applying a new generation of genetic maps to understand human inflammatory disease (2005) (36)
T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen. (1993) (36)
Lysosomal Cysteine and Aspartic Proteases Are Heterogeneously Expressed and Act Redundantly to Initiate Human Invariant Chain Degradation1 (2008) (36)
A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis (2019) (36)
Regulation of T cell clone function via CD4 and CD8 molecules. Anti-CD4 can mediate two distinct inhibitory activities. (1988) (36)
HTLV-I-induced T-cell activation. (1996) (36)
Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo. (2019) (36)
RNA Interference Screen in Primary Human T Cells Reveals FLT3 as a Modulator of IL-10 Levels (2009) (35)
Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. (2014) (35)
Systems Immunology Reveals Markers of Susceptibility to West Nile Virus Infection (2014) (35)
Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins (2015) (35)
Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. (2009) (35)
Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice (2019) (35)
CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls. (2003) (34)
Autoimmunity following viral infection: demonstration of monoclonal antibodies against normal tissue following infection of mice with reovirus and demonstration of shared antigenicity between virus and lymphocytes (1984) (34)
Engineered Interleukin-2 Antagonists for the Inhibition of Regulatory T Cells (2009) (34)
The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus (2006) (34)
Conserved CDR3 Regions in T-Cell Receptor (TCR) CD8+T Cells That Recognize the Tax11-19/HLA-A*0201 Complex in a Subject Infected with Human T-Cell Leukemia Virus Type 1: Relationship of T-Cell Fine Specificity and Major Histocompatibility Complex/Peptide/TCR Crystal Structure (2001) (33)
Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk (2018) (33)
A Review of T‐Cell Receptors in Multiple Sclerosis: Clonal Expansion and Persistence of Human T‐Cells Specific for an Immunodominant Myelin Basic Protein Peptide a (1995) (33)
A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility (2010) (33)
Pathology of an Islet Transplant 2 Years After Transplantation: Evidence for a Nonimmunological Loss (2008) (32)
The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle. (1991) (32)
T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice (1994) (32)
Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis (2011) (32)
Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes (2012) (31)
Frequency analysis of CD4+CD8+ T cells cloned with IL-4. (1990) (31)
Three‐year Open Protocol Continuation Study of Oral Tolerization with Myelin Antigens in Multiple Sclerosis and Design of a Phase III Pivotal Trial (1996) (31)
Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus (2013) (31)
Power estimation for non-standardized multisite studies (2016) (31)
Cathepsin S Regulates Class II MHC Processing in Human CD4+ HLA-DR+ T Cells1 (2009) (31)
T helper cell differentiation in multiple sclerosis and autoimmunity. (1998) (31)
Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme (2017) (30)
Loss of functional suppression is linked to decreases in circulating suppressor-inducer (CD4+2H4+) T cells in multiple sclerosis (1987) (30)
Role of Th1 and Th2 cells in neurologic disorders. (1996) (30)
Monoallelic expression of the human FOXP2 speech gene (2014) (30)
Protein array–based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis (2013) (30)
Induction and molecular signature of pathogenic T[subscript H]17 cells (2012) (29)
Solving Immunology? (2017) (29)
NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data (2021) (28)
Alterations in CD 46-mediated Tr 1 regulatory T cells in patients with multiple sclerosis (2006) (28)
What is the pathogenesis of human T‐cell lymphotropic virus type I–associated myelopathy/tropical spastic paraparesis? (1995) (28)
CTLA4Ig treatment in patients with multiple sclerosis An open-label, phase 1 clinical trial (2008) (28)
Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients. (1998) (28)
Embarrassment as the aura of a complex partial seizure (1982) (28)
Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis (1991) (28)
The TIGIT / CD 226 Axis Regulates Human (2012) (27)
Functional gamma chain-associated T cell receptors on cerebrospinal fluid-derived natural killer-like T cell clones (1987) (27)
Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells. (2005) (27)
Prostaglandin E2 Affects T Cell Responses through Modulation of CD46 Expression (2012) (27)
An Innate Role for IL-17 (2011) (27)
Antigen‐Driven Peripheral Immune Tolerance (1991) (26)
The Use of Cyclophosphamide in the Treatment of Multiple Sclerosis a (1984) (26)
Podoplanin is a negative regulator of Th17 inflammation. (2017) (26)
Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis (2010) (26)
Immunosuppression with high‐dose IV cyclophosphamide and ACTH in progressive multiple sclerosis: Cumulative 6‐year experience in 164 patients (1988) (25)
Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones. (1997) (25)
In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis. (2003) (24)
A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis (2010) (24)
Decreases in interleukin-4 secretion by invariant CD4(-)CD8(-)V alpha 24J alpha Q T cells in peripheral blood of patientswith relapsing-remitting multiple sclerosis. (2001) (24)
Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells (2021) (23)
Oleic acid restores suppressive defects in tissue-resident FOXP3 regulatory T cells from patients with multiple sclerosis. (2020) (23)
Increased IL-12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligand (1996) (23)
Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes. (1999) (23)
Noncanonical Vα24JαQ T cells with conservative α chain CDR3 region amino acid substitutions are restricted by CD1d (1999) (22)
Disease state prediction from single-cell data using graph attention networks (2020) (22)
Cytotoxic γδ T lymphocytes associated with an Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder (1996) (22)
Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone. (1999) (22)
Increased protein kinase C activity in human memory T cells. (1993) (21)
Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin (2003) (21)
Antigen‐specific TGF‐β1 Secretion with Bovine Myelin Oral Tolerization in Multiple Sclerosis (1996) (21)
HTLV-I-infected T cells evade the antiproliferative action of IFN-beta. (1999) (21)
Cross-reactivity of T-cell clones specific for altered peptide ligands of myelin basic protein. (1999) (20)
Multispecific responses by T cells expanded by endogenous self‐peptide/MHC complexes (2007) (20)
CXCR3+ T cells in multiple sclerosis correlate with reduced diversity of the gut microbiome (2019) (19)
Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis (2021) (19)
Immunosuppression with monoclonal antibodies in multiple sclerosis (1988) (19)
Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity (2020) (19)
Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients (2019) (19)
Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19 (2021) (19)
A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis (2010) (19)
Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals. (2010) (19)
The developing mosaic of autoimmune disease risk (2008) (18)
Comprehensive Phenotyping in Multiple Sclerosis: Discovery Based Proteomics and the Current Understanding of Putative Biomarkers (2006) (18)
The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations. (2016) (18)
Inflammatory cerebrospinal fluid t cells have activation requirements characteristic of cd4+cd45ra‐ t cells (1989) (18)
Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells (2020) (18)
Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis. (2016) (18)
Cytokines and Autoimmune Diseases (2001) (17)
Cytokines and interventional immunology (2007) (17)
Randomized phase IIb study of nivolumab (anti-PD-1; BMS-936558, ONO-4538) alone or in combination with ipilimumab versus bevacizumab in patients (pts) with recurrent glioblastoma (GBM). (2014) (17)
Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MS (2020) (17)
Therapy for multiple sclerosis. (1995) (16)
T Cell Subsets in Patients with Multiple Sclerosis: An Overview a (1984) (16)
Treatment of Multiple Sclerosis with Cyclophosphamide (1992) (16)
Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells (2022) (16)
Cross-reactivity of Borrelia burgdorferi and myelin basic protein-specific T cells is not observed in borrelial encephalomyelitis. (1999) (16)
Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity (2019) (15)
Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells. (2002) (15)
Protective and Therapeutic Role for α B-Crystallin in Autoimmune Demyelination (2007) (14)
Interleukin-1 corrects the defective autologous mixed lymphocyte response in multiple sclerosis. (1991) (14)
Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation. (1996) (14)
A novel population of B7‐1+ T cells producing intracellular IL‐4 is decreased in patients with multiple sclerosis (2000) (14)
Multiple sclerosis (2005) (14)
Co‐inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma (2017) (14)
Allelic Variation of MHC Structure Alters Peptide Ligands to Induce Atypical Partial Agonistic CD8+ T Cell Function (2003) (13)
The Purification and Functional Analysis of Human CD4+CD25high Regulatory T Cells (2006) (13)
Pilot Study of Oral Tolerance to Keyhole Limpet Hemocyanin in Humans. (1996) (13)
Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment (2017) (13)
Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk (2020) (13)
IMCT-03SAFETY AND ACTIVITY OF NIVOLUMAB MONOTHERAPY AND NIVOLUMAB IN COMBINATION WITH IPILIMUMAB IN RECURRENT GLIOBLASTOMA: UPDATED RESULTS FROM CHECKMATE-143. (2015) (12)
Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study (2021) (12)
GAD 65-reactive T cells are activated in patients with autoimmune type 1 a diabetes (2002) (12)
Immunoregulation in multiple sclerosis. (1989) (12)
Downregulation of IL‐10 secretion and enhanced antigen‐presenting abilities following HTLV‐I infection of T cells (1996) (12)
The Human Functional Genomics Project: Understanding Generation of Diversity (2016) (12)
Multiple sclerosis. (2018) (12)
A ‘‘Candidate-Interactome’’ Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis (2013) (12)
Autoimmunity. What is the turning point? (1999) (11)
Secondary immune amplification following live poliovirus immunization in humans. (1987) (11)
Uncoupling p 70 s 6 Kinase Activation and Proliferation : Rapamycin-Resistant Proliferation of Human CD 8 1 T Lymphocytes 1 (2001) (11)
Biological activity of recombinant human myelin basic protein (1993) (11)
Noncanonical Valpha24JalphaQ T cells with conservative alpha chain CDR3 region amino acid substitutions are restricted by CD1d. (1999) (11)
Antibodies to Myelin Basic Protein in Cerebrospinal Fluid of Patients with Multiple Sclerosis (1980) (11)
Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study (2022) (11)
TGF-b 1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage (2019) (10)
Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans (2020) (10)
Reactivity of normal T-cell lines to MBP isolated from normal and multiple sclerosis white matter (1995) (10)
Spatial-CITE-seq: spatially resolved high-plex protein and whole transcriptome co-mapping (2022) (10)
Immunotherapy in autoimmune diseases. (1991) (10)
Circulating Clonally Expanded T Cells Reflect Functions of Tumor Infiltrating T Cells (2020) (9)
Phase 2 Trial of Rituximab in Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis (2021) (9)
Antigen-Specific Immunosuppression: Oral Tolerance for the Treatment of Autoimmune Disease (1995) (9)
Cytotoxic gamma delta I lymphocytes associated with an Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder. (1996) (8)
Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune Cells (2021) (8)
Anti‐CD4 and Anti‐CD2 Monoclonal Antibody Infusions in Subjects with Multiple Sclerosis Immunosuppressive Effects and Human Antimouse Responses (1988) (8)
AKT isoforms modulate Th1‐like Treg generation and function in human autoimmune disease (2019) (8)
Autoimmunity. How to know thy self. (1996) (7)
High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq. (2023) (7)
Gene expression profiling in MS: what is the clinical relevance? (2004) (7)
Joint analysis reveals shared autoimmune disease associations and identifies common mechanisms (2021) (7)
Antigen-specific immunosuppression: oral tolerance for the treatment of autoimmune disease. (1995) (7)
Regulatory T Cell Function + highCD 25 + Inhibition of Human CD 4 (2002) (7)
Characterization of in vivo expanded OspA-specific human T-cell clones. (2005) (7)
B Cells, T Cells and Inflammatory CSF Biomarkers in Primary Progressive MS and Relapsing MS in the OBOE (Ocrelizumab Biomarker Outcome Evaluation) Trial (1635) (2020) (7)
The CD 6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD 4 + T Cell Proliferation (2011) (7)
Identification of a T Cell Subset Capable of both IFN-γ and IL-10 Secretion in Patients with Chronic Borrelia burgdorferi Infection (1998) (7)
Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting. (2018) (6)
The Potential of Restricted T Cell Recognition of Myelin Basic Protein Epitopes in the Therapy of Multiple Sclerosis (1991) (6)
Oral Communications (1995) (6)
Th1 and Th2 cells in health and disease (1996) (6)
TCR-sequencing in cancer and autoimmunity: barcodes and beyond. (2022) (6)
Sodium-activated macrophages: the salt mine expands (2015) (6)
Tropical spastic paraparesis on the Caribbean coast of Colombia. (1995) (6)
The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity (2021) (6)
Heterophile Antibodies Indicate Progression of Autoimmunity in Human Type 1 Diabetes Mellitus Before Clinical Onset (2001) (6)
Immunotherapy in autoimmune diseases (1992) (6)
Borrelia burgdorferi Chronic and IL-10 Secretion in Patients with γ IFN-Identification of a T Cell Subset Capable of both (1998) (5)
Antigen-Specific Immunosuppression: Oral Tolerance for the Treatment of Autoimmune Disease (Part 1 of 2) (1994) (5)
Lymphotropic Virus-Associated Myelopathy Complexes in Patients with Human T Cell with Soluble HLA-A 2 / Tax 11-19 Tetramer T Cells + Direct Analysis of Viral-Specific CD 8 (1999) (5)
Basic principles of neuroimmunology (2022) (5)
Genome-Wide Assessment for Genetic Variants Associated with Ventricular Dysfunction after Primary Coronary Artery Bypass Graft Surgery (2011) (5)
, remitting multiple sclerosis − relapsing Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from (2013) (5)
Neuron Interference: Evidence-Based Batch Effect Removal (2018) (5)
Functional differences between PD-1 + and PD-1-CD 4 + effector T cells in healthy donors and patients with glioblastoma multiforme (2017) (5)
Human Fetal Liver ' y / ~ T Cells Predominantly Use Unusual Rearrangements of the T Cell Receptor and " y Loci Expressed on Both CD 4 + CD 8-and C D 4C D 8-T Cells (2003) (5)
Molecular Mimicry in Multiple Sclerosis: Role of MHC-Altered Peptide Ligands (MAPL) (2004) (5)
Differential Responses of Invariant Vα24JαQ T Cells and MHC Class II-Restricted CD4+ T Cells to Dexamethasone (1999) (5)
Immunohistochemical analysis of suppressor-inducer and helper-inducer T cells in multiple sclerosis brain tissue (1987) (5)
Identification of a T Cell Subset Capable of both IFN-g and IL-10 Secretion in Patients with Chronic Borrelia burgdorferi Infection (1998) (4)
Oral Administration of Myelin Induces Antigen‐specific TGF‐β1‐secreting T Cells in Multiple Sclerosis Patients a (1997) (4)
Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferon b therapy in multiple sclerosis (2011) (4)
Loss of Functional Suppression Is Linked to Decreases in Circulating Suppressor‐Inducer (CD4+2H4+) T Cells in Multiple Sclerosis (1988) (4)
Perspective: Deconstructing a disease (2012) (4)
Multiple sclerosis enters a grey area (2019) (4)
Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells (2021) (4)
Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs. (2023) (3)
Switch of autoreactive human T cell clones from a TH2 to a TGFβ1 secreting phenotype with low affinity T-cell receptor stimulating peptide/MHC complex (1994) (3)
Distinct Inflammatory Profiles of Myelin-Reactive T cells from Patients with Multiple Sclerosis (2015) (3)
The TIGIT/CD226/CD155 axis is differentially expressed in MS and glioblastoma: implications for autoimmunity and tumor immune escape. (P4.043) (2015) (3)
F.21Characterization of the Myelin Specific Autoantibodies in Acute Disseminated Encephalomyelitis (2010) (3)
Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis (2022) (3)
Immunosuppression in progressive multiple sclerosis with high dose intravenous cyclophosphamide and monoclonal antibodies. (1987) (3)
Linking Genotype to Clinical Phenotype in Multiple Sclerosis: In Search of the Holy Grail. (2016) (3)
Regulatory T Cells in MS (2013) (3)
A phase Ib study of nivolumab in patients with autoimmune disorders and advanced malignancies (AIM-NIVO). (2020) (3)
Author Correction: A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis (2019) (3)
Chapter 52 – Multiple Sclerosis (2014) (3)
PD-1highCXCR5-CD4+ Peripheral Helper T (Tph) cells Promote Tissue-Homing Plasmablasts in COVID-19 (2021) (3)
More on Cetuximab in Head and Neck Cancer (2007) (3)
Experimental Approaches to Specific Immunotherapy in Multiple Sclerosis (1992) (3)
Multiple Sclerosis and Acute Disseminated Encephalomyelitis: Immunology (2014) (3)
Antigen-specific therapies for the treatment of autoimmune diseases (2004) (3)
F.27. Meta-analysis of Genome Scans and Replication Identify CD6, ICSBP1, and TNFRSF1A as Novel Multiple Sclerosis Susceptibility Loci (2009) (3)
Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonb therapy in multiple sclerosis (2012) (3)
T.22. Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Pro-inflammatory Cytokines Inducing Th17 Cells (2009) (3)
The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis. (1993) (2)
Su.86. Automated High-dimensional Flow Cytometric Data Analysis (2008) (2)
A multiple sclerosis–protective coding variant reveals an essential role for HDAC7 in regulatory T cells (2022) (2)
Immune tolerance and the nervous system. (2001) (2)
CHAPTER 46 – Multiple Sclerosis (2006) (2)
Prolonged benzodiazepine coma. (1981) (2)
Immunology: Insulin auto-antigenicity in type 1 diabetes (Reply) (2005) (2)
The role of immune deviation in regulation of experimental autoimmune encephalomyelitis and multiple sclerosis. In immunointervention in autoimmunity by Th1/Th2 regulation (1997) (2)
Response to Comment on “MHC Class II Expression Identifies Functionally Distinct Human Regulatory T Cells” (2008) (2)
Sequestration of virus-specific T cells in the cerebrospinal fluid of a patient with varicella zoster viral meningoencephalitis (1989) (2)
Anti-CD4 and anti-CD2 monoclonal antibodies infusions in multiple sclerosis: Immunosuppressive effects and human anti-mouse responses (1987) (2)
Human Dendritic Cells Common Genetic Variants Modulate Pathogen-Sensing Responses in (2014) (2)
Siponimod Chips Away at Progressive MS (2019) (2)
SclerosisMyelin Surface Antigen in Pediatric Multiple Age-Dependent B Cell Autoimmunity to a (2009) (2)
Cyclophosphamide and MS‐RRR (1994) (2)
Editorial: T Cell Regulation by the Environment (2015) (2)
Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity (2023) (2)
Correction: Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes (1999) (2)
Antigen-specific therapies for the treatment of autoimmune diseases. (1995) (2)
A phase 1b study of nivolumab in patients with autoimmune disorders and advanced malignancies (AIM-NIVO). (2)
Review of immunology. (1990) (2)
Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry. (2010) (2)
Dysregulation of the TIM-3-Galectin-9 Pathway in Type I Diabetic T Cells (2007) (1)
PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection (2022) (1)
IL-12 induces human CD4+CD45RA-CD25hiCD127low/neg regulatory T cells to secrete IFN{gamma} and IL-10 and acquire a non-regulatory effector phenotype (2010) (1)
Cells in Patients with Multiple Sclerosis Regulatory hi CD25+ Activity by Human CD4 CD2 Costimulation Reveals Defective (2011) (1)
In vitro evidence that immunuaffinity-purified MOG contains immunogenic quantities of contaminating mouse IgG; techniques for producing Ig-free MOG (2001) (1)
LYMPHOKINE REGULATION OF CD 45 R EXPRESSION ON HUMAN T CELL CLONES (2003) (1)
Oligocllonal T lymphocytes in the cerebrospinal fluid (CSF) of patients with chronic progressive multiple sclerosis (1987) (1)
Longitudinal single-cell analysis of a patient receiving adoptive cell therapy reveals potential mechanisms of treatment failure (2022) (1)
FlowCAP: comparison of automated and manual gating of standardized lyoplate flow cytometry data (P3374) (2013) (1)
Immune Infiltrates Expressing Podoplanin (PDPN) are Present in Multiple Sclerosis but not Glioblastoma (S12.002) (2015) (1)
Cell Function The TIGIT/CD226 Axis Regulates Human T (1)
CRRAO Advanced Institute of Mathematics, Statistics and Computer Science (AIMSCS) (2013) (1)
Single-cell transcriptomic and proteomic analysis of Parkinson’s disease Brains (2022) (1)
Analysis of αβ and γδ T cell receptors in multiple sclerosis plaques (1991) (1)
ANALYSIS OF ALPHA-BETA AND GAMMA-DELTA T-CELL RECEPTORS IN MS PLAQUES (1991) (1)
Population genetics meets single-cell sequencing. (2022) (1)
Correlation of Magnetic Resonance Imaging With Immune and Clinical Measures in 45 MS Patients Receiving 20 to 24 MRI Scans Each Over a 1 ‐Year Period (1995) (1)
Cumulative Experience with High‐Dose Intravenous Cyclophosphamide and ACTH Therapy in Chronic Progressive Multiple Sclerosis (1988) (1)
Thymic selection: to thine own self be true. (2015) (1)
Immunohistochemical Analysis of Suppressor‐Inducer and Helper‐Inducer T Cells in Multiple Sclerosis Brain Tissue (1988) (1)
Specific to a Single Viral Epitope T Cells + Among Different Clonal CD 8 Proliferation and Cytokine Production Similar Cytotoxicity but Variable Humans Using MHC Class I Tetramers : T Cell Function in + Examination of CD 8 (2000) (1)
An Autoimmune Transcriptional Circuit Driving Foxp3+ Regulatory T cell Dysfunction (2022) (1)
Single cell RNA sequencing reveals a novel, microglia-like cell type in cerebrospinal fluid during virologically suppressed HIV (2018) (1)
Multiple Sclerosis (2020) (1)
The CELLO trial: Protocol of a planned phase 4 study to assess the efficacy of Ocrelizumab in patients with radiologically isolated syndrome. (2022) (1)
Oligoclonal T Lymphocytes in the Cerebrospinal Fluid of Patients with Chronic Progressive Multiple Sclerosis (1987) (1)
Correction: The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+T Cell Proliferation (2012) (0)
F.34. Changes in the CD8dimCD4- Cell Population Parallel Disease Activity in Treated Multiple Sclerosis Subjects (2008) (0)
Detection of autoantibodies with self-assembling radiolabeled antigen tetramers (2007) (0)
Peripheral Blood CD4+CD25high Regulatory Cells in Human (2013) (0)
Abstract CT249: A phase 1b study of nivolumab in patients with autoimmune disorders and advanced malignancies (AIM-NIVO) (2020) (0)
Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity (2018) (0)
OR.31. Human TIM-3 Regulates Th1 and Th17 Cytokines (2009) (0)
High salt induces pathogenic Th17 cells and exacerbates autoimmune diseases (60.13) (2012) (0)
Sa.130. HLA-DR+ CD4+ T-Cells Have the Capacity to Present Endogenous Antigen (2006) (0)
Functional Characterization of Autoreactive T-cells in Acute Disseminated Encephalomyelitis 199 (1996) (0)
Sclerosis Fluid-Derived Mononuclear Cells in Multiple and Th 2 Cells and in Cerebrospinal Are Differentially Expressed on Human Th 1 Molecule-3 ( TIM-3 ) and TIM-1 (2004) (0)
Common genetic factors among autoimmune diseases (2023) (0)
Inhibition of T Cell Responses by Activated Human CD8+ T Cells is Mediated by Interferon-y and is Defective in Chronic Progressive Multiple Sclerosis (2004) (0)
In vivo clonal depletion of human myelin basic protein-reactive T cells by T cell vaccination (1994) (0)
Levels Cells Reveals FLT 3 as a Modulator of IL-10 RNA Interference Screen in Primary Human T Data (2009) (0)
Sodium Chloride Drives the Induction of Pathogenic Th17 Cells (S11.004) (2013) (0)
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 42-1990. A previously healthy 41-year-old man with meningoencephalitis and the rapid development of coma. (1990) (0)
F.89. Elucidating the Antigen Specificity of B Cells Present within the CNS Lesions of Patients with MS (2009) (0)
Regulation of Immunological Tolerance and Autoimmunity by the Enzyme Sialic Acid Acetylesterase (SIAE) (2010) (0)
Treatment of multiple sclerosis and other autoimmune diseases by oral tolerance to autoantigens (1995) (0)
SY-23 Human CD4+CD25high natural Tregs and Th17 effector cells are related (2008) (0)
Elifacs: A Multiplex Assay to Detect Antigen Specific T Cells and to Monitor the Immune Response (2007) (0)
Increasing the down-regulation of autoimmune diseases by oral or enteral administration of autoantigens (1991) (0)
Suppression of autoimmune diseases by antigenic in wartestellung (1993) (0)
OR.39. Enumeration and Phenotype of Autoreactive B Cells in Pancreatic Draining Lymph Nodes from Type 1 Diabetes Subjects (2009) (0)
CBM-05FUNCTIONAL DIFFERENCES BETWEEN PD-1+ AND PD-1– CD4+ T EFFECTOR CELLS IN HEALTHY DONORS AND PATIENTS WITH GLIOBLASTOMA (2015) (0)
Large Scale Immunoprofiling Uncovers Population Structure in Untreated MS Subjects and Highlights the Role of NK Cells (2007) (0)
T Cell Regulation by the Environment (2015) (0)
OR.72. Enhanced Recognition of Insulin a Chain 1-15 By Expanded T-Cell Clones from Human Type 1 Diabetic (T1D) Pancreatic Draining Lymph Nodes (2006) (0)
Contribution Variation Within DNA Repair Pathway Genes and Risk of Multiple Sclerosis (2010) (0)
Improved repressor regulation of autoimmune diseases by oral or enteral administration of autoantigens. (1991) (0)
Title Minimum Information about T Regulatory Cells : A Step toward Reproducibility and Standardization Permalink (2018) (0)
Epigenetic fine-mapping: identification of causal mechanisms for autoimmunity. (2020) (0)
Altered Synapse Formation by Self-reactive T Cells from MS Patients (2010) (0)
Investigation of novel type 1 diabetes loci in multiple sclerosis (2009) (0)
HTLV-1 induced spontaneous T cell clonal proliferation is rapamycin sensitive (1991) (0)
THERAPEUTIC OR PROPHYLACTICAGENT FOR MULTIPLE SCLEROSIS (2017) (0)
Treatment of autoimmune diseases by administration of autoantigen in the form of aerosol (1990) (0)
Decreases in IL-4 secretion by invariant Vα24JαQT cells in peripheral blood of patients with multiple sclerosis (MS) (1998) (0)
CTLA4 blockade enhances B7-2 dependent Th-2 cytokine production from human MBP-reactive T-cells (1998) (0)
Multiple sclerosis (WS-038) Chairpersons: Jyun-ichi Kira, Richard Ransohoff (2010) (0)
Redundantly to Initiate Human Invariant Are Heterogeneously Expressed and Act Lysosomal Cysteine and Aspartic Proteases (2008) (0)
Methods of treating autoimmune uveoretnitis in humans (1990) (0)
A biological pathway approach to disease association studies: Toll receptor pathway alleles and susceptibility to inflammatory bowel disease (2006) (0)
Sa.27. Genotype/Phenotype and Epistasis Analyses of Toll-Like Receptor Pathway Alleles Associated with Risk of Inflammatory Bowel Disease (2006) (0)
An Association Between the Autoimmune Susceptibility Locus CTLA4 and Alterations in Proximal TCR Signaling in Healthy Human Volunteers (2007) (0)
Edinburgh Research Explorer Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis (2018) (0)
Microfluidic immuno-serology assay revealed a limited diversity of protection against COVID-19 in patients with altered immunity (2022) (0)
Peripheral Blood Regulatory Cells in Human high CD25+ CD4 (0)
Oligodendrocyte Glycoprotein System Tissue Recognize Myelin Antibodies from Inflamed Central Nervous (2005) (0)
TIM-3 is a Negative Regulator of Human Th1 Cells (2007) (0)
The PhenoGenetic Project: A Living Biobank Enabling the Study of Human Genetic and Immunologic Variation (2010) (0)
F.108. DNA Methylation of the Human FoxP3 Locus Differs Significantly Between Functionally Distinct Subpopulations of CD4+CD25high Human Regulatory T Cells (2009) (0)
Author Correction: Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity (2019) (0)
Oral autoantigenholdigt preparation (1989) (0)
In Search of the Holy Grail: Linking Genotype to Clinical Phenotype in Multiple Sclerosis (2016) (0)
Prostaglandin E 2 affects T cell responses through modulation of CD 46 expression 1 (2013) (0)
Improving Elispot to Detect Antigen Specific T Cells (2007) (0)
Cytokines in New-Onset Refractory Status Epilepticus (NORSE) predict outcomes. (2023) (0)
OR.102. The CD58 Pathway is Implicated in MS Susceptibility (2008) (0)
Multiple Sclerosis II-Binding CD4 Cells in Patients with Oligodendrocyte Glycoprotein/MHC Class Increased Frequencies of Myelin (2011) (0)
Characterization of Single B Cell Immunoglobulin Variable Region Genes Derived from Infiltrated Muscle Tissue of Subjects with Inflammatory Myopathies (2007) (0)
Efficient Activation of Self-reactive T Cells from MS Patients with Altered Synapse Formation (2010) (0)
CBM-04PD-1 EXPRESSION IDENTIFIES EXHAUSTED TUMOR INFILTRATING REGULATORY T CELLS IN GLIOBLASTOMA. (2015) (0)
Comparative scRNA-seq Analysis of Peripheral Blood Mononuclear Cells from Patients with COVID-19 and Idiopathic Pulmonary Fibrosis Demonstrates Dissimilar Cell Shifts and Gene Expression Profiles (2021) (0)
Loss of Foxp3+ Regulatory T cell Function in Glioblastoma (P4.240) (2015) (0)
Effect of CD28/CTLA4 signaling on function of MBP reactive T cells (1998) (0)
Admixture Mapping, a New Tool for Disease Gene Finding in Autoimmune and Other Diseases (2007) (0)
Sa.25. In Vitro Correlates of in Vivo Rapamycin Therapy in Patients with Multiple Sclerosis (2006) (0)
Sa.128. Comparison of Two Methods to Isolate Mononuclear Cells from Peripheral Blood On Viability and Function of Freshly and Cryopreserved PBMCS (2006) (0)
T-cell receptor-γ-chain clones with natural killer-like activity in the cerebrospinal fluid (1987) (0)
Interleukin-9 Secretion by Human Th17 Cells is Inducible by TGF-β and Proinflammatory Cytokines and is Increased in Autoimmune Diabetes (2010) (0)
Immunosuppression with high-dose I.V. cyclophosphamide and acth in progressive multiple sclerosis Cumulative experience in 100 patients (1987) (0)
through Modulation of CD46 Expression Affects T Cell Responses 2 Prostaglandin E (2012) (0)
IL-1 Receptor Expression on Human Regulatory T Cells and IL-1β's Role in Reducing Suppression (2010) (0)
F.14. Autoantibodies to Myelin Oligodendrocyte Glycoprotein in Pediatric MS (2008) (0)
Sa.137. Toll-Like Receptor Pathway Polymorphisms and Association to Inflammatory Bowel Disease (2006) (0)
OR.43. Comparative Analysis of B Cell Repertoires Among Lesions and Normal Appearing White Matter in the Multiple Sclerosis Central Nervous System (2009) (0)
Analysis of Autoreactive T-Cells in Type I Diabetes (2006) (0)
HST.176 Cellular and Molecular Immunology, Fall 2002 (2002) (0)
Overproduction of Pro-inflammatory Cytokines in New-Onset Refractory Status Epilepticus (NORSE) (S35.002) (2023) (0)
Increased expression of CDIIb (mac-1) on CD8+ T cells in patients with HAM/TSP (1998) (0)
OR.80. Identifying Regulators of Cytokine Production in Primary Human T-Cells Using a Lentiviral RNAi Library (2006) (0)
CHAPTER 2. Genetics of Multiple Sclerosis (2019) (0)
Haplotype-specific Use of Lysosomal Proteases Can Modulate the Class II MHC Peptide Repertoire but Does Not Impair Invariant Chain Degradation in Human Antigen Presenting Cells (2007) (0)
Human Glioblastoma Multiforme (GBM) Tumors are Enriched for Strongly Suppressive, Apoptosis Resistant, DR+ Tregs (2007) (0)
OR.22. Dissection of the Admixture Multiple Sclerosis Susceptibility Locus On Chromosome 1 in An African-American Population (2006) (0)
Novel Computational Methods to Enhance the Analysis of Cytometric Immunophenotypes (2007) (0)
The role of the CD[subscript 5]8 locus in multiple sclerosis (2009) (0)
BASICITY TOWARD BORANE OF SIMPLE PHOSPHITES (1975) (0)
Increased Frequencies of Myelin Reactive CCR6+ Pathogenic IL-17/GM-CSF/IFNγ Secreting CD4+ T Cells in Patients with Multiple Sclerosis (P03.225) (2013) (0)
RNAi screen of human primary T cells reveals FLT3 as a new regulator of IL-10 production (2008) (0)
Sa.115. IL7R and HLA-Class II selected FoxP3+ Natural Regulatory T Cells (nTregs) Represent Effector nTregs, Precursor nTregs, and Induced nTregs (2008) (0)
Identiﬁcation of a T Cell Subset Capable of both IFN- g and IL-10 Secretion in Patients with Chronic Borrelia burgdorferi Infection 1 (1998) (0)
Single-cell transcriptomic atlas of Alzheimer's disease middle temporal gyrus reveals region, cell type and sex specificity of gene expression with novel genetic risk for MERTK in female (2023) (0)
Clinical neuroimmunology edited by J.A. Aarli, M.W.H. Behan and P.O. Behan, Blackwell Scientific Publications, 1987. £60.00 (xviii + 531 pages) ISBN O 632 01635 x. (1988) (0)
Monocytes from Patients with Type 1 Diabetes Have Increased Gene Expression of Pro-inflammatory Cytokines or IL-10 (2010) (0)
Method of treating or preventing autoimmune uveoretinitis in mammals (1990) (0)
Solution NMR Structure of Insulin A-chain peptide (2010) (0)
Cytokines and Human Type 1 Diabetes (2002) (0)
Immunotherapeutic Approaches for Multiple Sclerosis* (2019) (0)
Protein A-Reactive T Cells Is a Partial Agonist for Outer SurfaceL α LFA-1 Demonstrated at the Single Cell Level : Molecular Mimicry in Lyme Arthritis (2001) (0)
Differential Expression of the T cell Inhibitor TIGIT in Glioblastoma and Multiple Sclerosis (2019) (0)
IL-10 Levels T Cells Reveals FLT3 as a Modulator of RNA Interference Screen in Primary Human (2009) (0)
Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice (2019) (0)
IL-10 Both Inhibits Treg Suppressive Activity and is a Survival Factor for Human Natural Tregs (2007) (0)
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci | NOVA. The University of Newcastle's Digital Repository (2011) (0)
Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis (2018) (0)
Corrigendum to "Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo" [Yjaut 96C (2019) 40-49]. (2019) (0)
CellsDistinct Human Regulatory T MHC Class II Expression Identifies (2013) (0)
Sa.30. Characterization of B-Cell Immunoglobulin Variable Region Genes Derived from Muscle Tissue of Subjects with Inflammatory Myopathies (2006) (0)
Oleic acid Induces Tissue Resident FoxP3 Regulatory T cell Lineage Stability and Suppressive Functions (2020) (0)
How B Cells Contribute to Multiple Sclerosis Pathology (2007) (0)
Differential activation of cytolysis and proliferation in HTLV-I tax-reactive CD8 T cells by a single amino acid substitution in a T cell receptor contact residue of the peptide antigen (1994) (0)
Oral toleralization to keyhole limpet hemocyanin in humans (1991) (0)
Sa.13. Function of TIM3 May Be Compromised in Human CD4 T-Cells of Untreated Patients with Multiple Sclerosis (2006) (0)
Sa.9. Examination of the B-Cell Repertoire in the CNS of Patients with MS (2006) (0)
Sa.43. Role of the HLA DRB1*1501 Risk Haplotype in the Expression of Clinical and Radiographic Phenotypes of Multiple Sclerosis (2006) (0)
CBM-06IMMUNE BIOMARKER RESULTS FROM A TRIAL OF NIVOLUMAB ± IPILIMUMAB IN PATIENTS WITH RECURRENT GLIOBLASTOMA: CHECKMATE-143 (2015) (0)
Chapter 3 - Uncovering the Genetic Architecture of Multiple Sclerosis (2010) (0)
SP0104 The Molecular Basis of Autoimmune Disease (2014) (0)
Identification of Pathogenic IL-17 Producing FOXP3+ Tregs in Patients With De Novo Autoimmune Hepatitis.: Abstract# A4 (2014) (0)
F.33. Genetic Variants that Control the Expression of MHC Genes Do Not Affect Susceptibility to Multiple Sclerosis (2008) (0)
Diabetic Pancreatic Draining Lymph Node Loss of IL-4 Secretion from Human Type 1a (2005) (0)
Allele Is Associated with Alterations in CD 4 Multiple Sclerosis Susceptibility CD 6 The Mousissian (2011) (0)
Author Correction: Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity (2019) (0)
Cytolytic Potential of CD3+4-8- T Cells with Differently Organized T Cell Receptor Y Chains (1988) (0)
Regulatory T cells in autoimmune disease (2018) (0)
Regulatory T cells in peripheral tissue tolerance and diseases (2023) (0)
This information is current as Acetate Synthetic Random Polypeptide Glatiramer a Complex Antigen : Recognition of the Human and Murine CD 4 T Cell Reactivity to (2000) (0)
NpgRJ_Ng_2007-27 1..6 (2007) (0)
High Dietary Salt Aggravates Experimental Neuroinflammation in Mice Via Induction of Th17 Cells (S50.003) (2013) (0)
Interaction (1988) (0)
IRF 5 gene variants and pharmacologi al and clinical outcome of IFN-β therapy in MS (2014) (0)
Sa.114. IL-10 and Granzyme B Inhibits Suppression by Human DR+ Effector nTregs (2008) (0)
F.108. Further Characterizations of Human CD4+ CD25+ Regulatory T-Cells (2006) (0)
Sa.109. Allelic and Phenotypic Heterogeneity at the Autoimmune Susceptibility Locus IL2RA (2008) (0)
In vitro analysis of T-cell responses to Copaxone® (1998) (0)
Sa.77. Ex Vivo Activated State of Type 1 Diabetic Monocytes (2008) (0)
Characterization of the B Cell Infiltrate Within Intracranial Germinomas (2007) (0)
The potential for targeting CD4+CD25+ regulatory T cells in the treatment of multiple sclerosis in humans (2005) (0)
Modification of immune responses to myelin basic protein (MBP) using altered peptide ligands (1995) (0)
Multiple sclerosis enters a grey area (2019) (0)
Genetics of autoimmunity (SY6-1) Chairpersons: Takehiko Sasazuki, Judy H. Cho (2010) (0)
Activated T-Cells and Antigen Reactivity in the Cerebrospinal Fluid and Blood of Patients with Multiple Sclerosis (1987) (0)
Correction: Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting. (2018) (0)
PTGER2-β-Catenin Axis Links High Salt Environments to Autoimmunity by Balancing IFNγ and IL-10 in FoxP3+ Regulatory T cells (2018) (0)
S.67. Detection of Myelin Reactive CD4+Cells in the Peripheral Blood of Patients with Multiple Sclerosis using MHC Class II Tetramers (2009) (0)
II Molecules Antigens Presented by Different MHC Class Cross-Reactive TCR Responses to Self (2004) (0)
Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells (2021) (0)
OR.55. Transforming Growth Factor-beta is Crucial for the Differentiation and Regulation of Interleukin 9-producing Human CD4+T Cells (2009) (0)
Dissecting the Functional Consequences of the Validated Multiple Sclerosis Susceptibility Allele in TNFRSF1A (2010) (0)
S.119. CD127 and HLA DR Define Functionally Distinct Human Tregs- One Subsets Exhibits Decreased Activity in Multiple Sclerosis (2009) (0)
S.132. Cathepsin S Regulates MHC Class II Processing in Human CD4+HLA-DR+T Cells (2009) (0)
vy 6 T-cell receptor repertoire in acute multiple sclerosis lesions (0)
List of Contributors (2020) (0)
CTLA4 engagement can have both positive and negative effects on human T cell activation (1998) (0)
Fatty Acid Metabolism and T Cells in Multiple Sclerosis (2022) (0)
23Na imaging: Worth its salt for understanding multiple sclerosis (2021) (0)
OR.4. Cellular Senescence in Terminally Differentiated Human CD4+CD25hi IL-7Rneg HLA-DR+Regulatory T Cells (2009) (0)
Balance in Humans (Th1/Th17)/Anti-Inflammatory (Th2) Proinflammatory The CD226/CD155 Interaction Regulates the (2013) (0)
AKT isoforms modulate Th 1-like Foxp 3 + regulatory T cell generation and function in human autoimmune disease (2016) (0)
Neutrophils regulate ITPR2 levels in epithelia by direct injection of elastase (2022) (0)
Defect in TIM-3 Regulation of CD4+ T Cells in a Human Autoimmune Disease (2007) (0)
Neuroimmune interactions in health and disease (2022) (0)
OR.39. Differentiation of Natural Human CD4+CD25high Tregs to Th17 Effector Cells (2008) (0)
RESTRICTED GAMMA-DELTA T-CELL RECEPTORS IN MULTIPLE-SCLEROSIS LESIONS (1992) (0)
A Genome-wide Screen for Genetic Variants Affecting the Expression of Immunologically Relevant Cell Surface Markers (2007) (0)
Re: GAMES issue study: Are international genetic consortia functional? (2004) (0)
Flt3, a New Regulator of IL-10 Production by Human T Cells, Identified Using an RNAi Library (2008) (0)
Tim-4 Expressed on Antigen-presenting Cells Induces T Cell Expansion and Survival (2007) (0)
Enhancement of suppression regulation of autoimmune diseases by oral or enteral administration of autoantigens (1991) (0)
Towfique Raj Risk Alleles in Leukocytes Polarization of the Effects of Autoimmune and Neurodegenerative (2014) (0)
ProtAnno, an Automated Cell Type Annotation Tool for Single Cell Proteomics Data that integrates information from Multiple Reference Sources (2021) (0)
Levels Cells Reveals FLT3 as a Modulator of IL-10 RNA Interference Screen in Primary Human T (2011) (0)
Comprar How Do We Best Employ Animal Models for Type 1 Diabetes and Multiple Sclerosis? | MATTHIAS VON HERRATH | 9781573316781 | Blackwell Publishing (2007) (0)
Sa.102. Discovery and Characterization of Novel Human TIM-3 Splice Variants (2008) (0)
Book ReviewAll of a Piece: A life with multiple sclerosis (1989) (0)
Progressive Multiple Sclerosis Are Activated Myeloid Dendritic Cells in Secondary Innate Immunity in Multiple Sclerosis: (2006) (0)
Cell Expansion and Survival TIM-4 Expressed on APCs Induces T (2010) (0)
Treatment of autoimmune uveoretinitis in humans (1990) (0)
IL-12 induces human CD4+CD45RA-CD25hiCD127low/neg regulatory T cells to secrete IFNγ and IL-10 and acquire a non-regulatory effector phenotype (138.9) (2010) (0)
OR.9. Il-10 Plays a Contrasting Role in Suppression By Functionally Distinct, Dr+ and Dr− Human Natural Regulatory T-Cells (2006) (0)

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