Darwin Prockop

Q: What Schools Are Affiliated With Darwin Prockop

Darwin Prockop is affiliated with the following schools: Texas A&M University, University of Oulu, Karolinska Institute, University of Pennsylvania, University of Oslo, George Washington University, University of California, Berkeley, University of Oxford, Thomas Jefferson University, Tulane University, Haverford College, Rutgers University, Allegheny University of the Health Sciences, Texas A&M Health, Stanford University

Darwin Prockop's AcademicInfluence.com Rankings

Darwin Prockop

Biology

#1380

World Rank

#2322

Historical Rank

#697

USA Rank

Molecular Biology

#82

World Rank

#85

Historical Rank

#52

USA Rank

Genetics

#82

World Rank

#116

Historical Rank

#53

USA Rank

biology Degrees

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Biology

Darwin Prockop's Degrees

PhD Biology University of California, Berkeley
Masters Genetics Stanford University

Why Is Darwin Prockop Influential?

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According to Wikipedia, Darwin Prockop is an American biochemist and progenitor cell researcher. He has held academic posts at several universities, and has been a faculty member at the Texas A&M Health Science Center since 2008. Prockop has been elected to several academic societies, including the National Academy of Sciences and the Institute of Medicine.

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Darwin Prockop's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues (1997) (4607)
Adult rat and human bone marrow stromal cells differentiate into neurons (2000) (2507)
Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta (1999) (1882)
Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair—Current Views (2007) (1858)
Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. (1999) (1688)
Collagens: molecular biology, diseases, and potentials for therapy. (1995) (1614)
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. (2009) (1606)
An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction. (2004) (1380)
Modifications of a specific assay for hydroxyproline in urine. (1967) (1067)
A specific method for the analysis of hydroxyproline in tissues and urine. (1960) (1048)
Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential. (2004) (1025)
Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. (2000) (1018)
Expansion of Human Adult Stem Cells from Bone Marrow Stroma: Conditions that Maximize the Yields of Early Progenitors and Evaluate Their Quality (2002) (972)
Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery (2002) (971)
Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats--similarities to astrocyte grafts. (1998) (950)
Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. (1995) (937)
Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells (2001) (925)
Propagation and senescence of human marrow stromal cells in culture: a simple colony‐forming assay identifies samples with the greatest potential to propagate and differentiate (1999) (922)
Mitochondrial transfer between cells can rescue aerobic respiration (2006) (801)
Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties (2010) (780)
Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice (2006) (764)
Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: evidence for solvent-induced bends in DNA heteroduplexes. (1993) (696)
In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis (2002) (671)
Sarcoma Derived from Cultured Mesenchymal Stem Cells (2007) (628)
Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans (2007) (612)
Modified procedure for the assay of H-3-or C-14-labeled hydroxyproline. (1966) (599)
Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: Variations in yield, growth, and differentiation (1999) (579)
Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms. (2009) (578)
Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation. (2012) (562)
Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. (1998) (562)
Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. (2001) (558)
Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages. (2011) (553)
Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma (2003) (537)
The thermal transition of a non-hydroxylated form of collagen. Evidence for a role for hydroxyproline in stabilizing the triple-helix of collagen. (1973) (505)
In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP. (2001) (502)
Donor variation in the growth properties and osteogenic potential of human marrow stromal cells (1999) (491)
Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy. (2004) (489)
Heritable diseases of collagen. (1984) (488)
One strategy for cell and gene therapy: Harnessing the power of adult stem cells to repair tissues (2003) (449)
Angiogenic Effects of Human Multipotent Stromal Cell Conditioned Medium Activate the PI3K‐Akt Pathway in Hypoxic Endothelial Cells to Inhibit Apoptosis, Increase Survival, and Stimulate Angiogenesis (2007) (438)
Mutations in collagen genes: causes of rare and some common diseases in humans (1991) (423)
Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses (2008) (407)
Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice. (2005) (399)
Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment. (2007) (384)
An allele of COL9A2 associated with intervertebral disc disease. (1999) (363)
Human Mesenchymal Stem/Stromal Cells Cultured as Spheroids are Self‐activated to Produce Prostaglandin E2 that Directs Stimulated Macrophages into an Anti‐inflammatory Phenotype (2012) (351)
Mutations in fibrillar collagens (types I, II, III, and XI), fibril‐associated collagen (type IX), and network‐forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels (1997) (344)
Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene. (1999) (336)
Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma (2005) (322)
Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI (2015) (317)
Short-Term Exposure of Multipotent Stromal Cells to Low Oxygen Increases Their Expression of CX3CR1 and CXCR4 and Their Engraftment In Vivo (2007) (316)
The zipper-like folding of collagen triple helices and the effects of mutations that disrupt the zipper. (1991) (311)
Adipogenic Differentiation of Human Adult Stem Cells From Bone Marrow Stroma (MSCs) (2003) (309)
BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells. (2001) (305)
Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: potential therapy for cystic fibrosis. (2005) (299)
The Wnt Signaling Inhibitor Dickkopf-1 Is Required for Reentry into the Cell Cycle of Human Adult Stem Cells from Bone Marrow* (2003) (294)
Stem cells and cell therapies in lung biology and lung diseases. (2008) (290)
Radial packing, order, and disorder in collagen fibrils. (1995) (288)
Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation. (2005) (286)
Defining the risks of mesenchymal stromal cell therapy. (2010) (284)
Rat Marrow Stromal Cells are More Sensitive to Plating Density and Expand More Rapidly from Single‐Cell‐Derived Colonies than Human Marrow Stromal Cells (2001) (280)
The biosynthesis of collagen. 1. (1972) (278)
Stop codon in the procollagen II gene (COL2A1) in a family with the Stickler syndrome (arthro-ophthalmopathy). (1991) (275)
Single base mutation in the type II procollagen gene (COL2A1) as a cause of primary osteoarthritis associated with a mild chondrodysplasia. (1990) (267)
Proteolytic enzymes as probes for the triple-helical conformation of procollagen. (1981) (267)
Relationship of Hydroxyproline Excretion in Urine to Collagen Metabolism: Biochemistry and Clinical Applications (1967) (262)
A Crosstalk Between Myeloma Cells and Marrow Stromal Cells Stimulates Production of DKK1 and Interleukin‐6: A Potential Role in the Development of Lytic Bone Disease and Tumor Progression in Multiple Myeloma (2006) (259)
Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs) (2010) (259)
Synthesis and extrusion of collagen by freshly isolated cells from chick embryo tendon (1971) (254)
Assembly of collagen fibrils de novo by cleavage of the type I pC-collagen with procollagen C-proteinase. Assay of critical concentration demonstrates that collagen self-assembly is a classical example of an entropy-driven process. (1987) (253)
Conformation sensitive gel electrophoresis for simple and accurate detection of mutations: comparison with denaturing gradient gel electrophoresis and nucleotide sequencing. (1998) (251)
Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone. (1995) (250)
Mutations in COL11A2 cause non-syndromic hearing loss (DFNA13) (1999) (249)
Serum deprivation of human marrow stromal cells (hMSCs) selects for a subpopulation of early progenitor cells with enhanced expression of OCT-4 and other embryonic genes. (2004) (248)
Synthesis of (Pro-Hyp-Gly) n of defined molecular weights. Evidence for the stabilization of collagen triple helix by hydroxypyroline. (1973) (247)
Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus (2017) (246)
Review: ex vivo engineering of living tissues with adult stem cells. (2006) (241)
Splicing mutations of 54-bp exons in the COL11A1 gene cause Marshall syndrome, but other mutations cause overlapping Marshall/Stickler phenotypes. (1999) (239)
Nucleotide sequences of complementary deoxyribonucleic acids for the pro alpha 1 chain of human type I procollagen. Statistical evaluation of structures that are conserved during evolution. (1983) (239)
Action at a Distance: Systemically Administered Adult Stem/Progenitor Cells (MSCs) Reduce Inflammatory Damage to the Cornea Without Engraftment and Primarily by Secretion of TNF‐α Stimulated Gene/Protein 6 (2011) (234)
Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6 (2011) (217)
Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions. (2007) (215)
Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury (2010) (213)
Folding mechanism of the triple helix in type-III collagen and type-III pN-collagen. Role of disulfide bridges and peptide bond isomerization. (1980) (212)
Structure of a cDNA for the pro alpha 2 chain of human type I procollagen. Comparison with chick cDNA for pro alpha 2(I) identifies structurally conserved features of the protein and the gene. (1983) (209)
Isolation and characterization of rapidly self-renewing stem cells from cultures of human marrow stromal cells. (2001) (206)
Intracellular Steps in the Biosynthesis of Collagen (1976) (203)
The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1. (1996) (196)
Concise Review: Two negative feedback loops place mesenchymal stem/stromal cells at the center of early regulators of inflammation (2013) (189)
Cloning and Characterization of ADAMTS-14, a Novel ADAMTS Displaying High Homology with ADAMTS-2 and ADAMTS-3* (2002) (188)
A mutation in the gene for type III procollagen (COL3A1) in a family with aortic aneurysms. (1990) (187)
MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis (2017) (185)
Procollagen N-proteinase and procollagen C-proteinase. Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling. (1998) (183)
Human multipotent stromal cells from bone marrow and microRNA: Regulation of differentiation and leukemia inhibitory factor expression (2008) (183)
Multipotential marrow stromal cells transduced to produce L-DOPA: engraftment in a rat model of Parkinson disease. (1999) (181)
The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice. (2009) (181)
Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1. (2009) (178)
Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation. (2012) (177)
A STUDY OF URINARY AND SERUM LYSOZYME IN PATIENTS WITH RENAL DISEASE. (1964) (174)
Osteogenesis imperfecta: cloning of a pro-alpha 2(I) collagen gene with a frameshift mutation. (1984) (174)
cDNA clones coding for the pro-alpha1(IV) chain of human type IV procollagen reveal an unusual homology of amino acid sequences in two halves of the carboxyl-terminal domain. (1985) (173)
The triple helix ⇌ coil conversion of collagen‐like polytripeptides in aqueous and nonaqueous solvents. Comparison of the thermodynamic parameters and the binding of water to (L‐Pro‐L‐Pro‐Gly)n and (L‐Pro‐L‐Hyp‐Gly)n (1977) (171)
The biosynthesis of collagen and its disorders (first of two parts). (1979) (171)
Analysis of the COL1A1 and COL1A2 genes by PCR amplification and scanning by conformation-sensitive gel electrophoresis identifies only COL1A1 mutations in 15 patients with osteogenesis imperfecta type I: identification of common sequences of null-allele mutations. (1998) (169)
Two improved methods for preparing ferritin-protein conjugates for electron microscopy (1975) (169)
The collagen fibril: the almost crystalline structure. (1998) (169)
Dynamic compaction of human mesenchymal stem/precursor cells into spheres self‐activates caspase‐dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1) (2013) (166)
Genetic linkage of a polymorphism in the type II procollagen gene (COL2A1) to primary osteoarthritis associated with mild chondrodysplasia. (1990) (166)
cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components. (1997) (164)
TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo (2014) (164)
Significance of urinary hydroxyproline in man. (1961) (159)
Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen. (2012) (156)
Internal deletion in a collagen gene in a perinatal lethal form of osteogenesis imperfecta (1983) (155)
How Wnt Signaling Affects Bone Repair by Mesenchymal Stem Cells from the Bone Marrow (2005) (151)
Time lag in the secretion of collagen by matrix-free tendon cells and inhibition of the secretory process by colchicine and vinblastine. (1972) (150)
Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization. (1985) (149)
Enzymatic hydroxylation of proline and lysine in protocollagen. (1967) (149)
Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response. (2012) (148)
ISOTOPIC STUDIES ON COLLAGEN DEGRADATION AND THE URINE EXCRETION OF HYDROXYPROLINE. (1964) (145)
Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension (2008) (144)
Multipotent mesenchymal stromal cells attenuate chronic inflammation and injury-induced sensitivity to mechanical stimuli in experimental spinal cord injury. (2009) (143)
Adult Bone Marrow Stem/Progenitor Cells (MSCs) Are Preconditioned by Microenvironmental "Niches" in Culture: A Two-Stage Hypothesis for Regulation of MSC Fate (2005) (142)
Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia. (1991) (137)
A rapid and simple PCR-based method for isolation of cDNAs from differentially expressed genes. (1994) (137)
Inhibition of the Self-assembly of Collagen I into Fibrils with Synthetic Peptides (1998) (136)
Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta. (1991) (134)
Why should mesenchymal stem cells (MSCs) cure autoimmune diseases? (2010) (134)
Hydroxylation of proline in synthetic polypeptides with purified protocollagen hydroxylase. (1967) (134)
Exclusion of mutations in the gene for type III collagen (COL3A1) as a common cause of intracranial aneurysms or cervical artery dissections (1993) (131)
Central-nervous-system effects of ingestin of L-tryptophan by normal subjects. (1962) (131)
Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases. (2000) (131)
Isotopic studies on urinary hydroxyproline as evidence for rapidly catabolized forms of collagen in the young rat. (1961) (127)
Incorporation of proline analogues into collagen polypeptides Effects on the production of extracellular procollagen and on the stability of the triple-helical structure of the molecule☆ (1974) (125)
Copolymerization of pNcollagen III and collagen I. pNcollagen III decreases the rate of incorporation of collagen I into fibrils, the amount of collagen I incorporated, and the diameter of the fibrils formed. (1991) (124)
A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice. (2006) (124)
Mutations that alter the primary structure of type I collagen. The perils of a system for generating large structures by the principle of nucleated growth. (1990) (124)
Cloning a cDNA for the pro-alpha 2 chain of human type I collagen. (1981) (123)
Modulation of procollagen gene expression by retinoids. Inhibition of collagen production by retinoic acid accompanied by reduced type I procollagen messenger ribonucleic acid levels in human skin fibroblast cultures. (1985) (121)
Evidence for a structural mutation of procollagen type I in a patient with the Ehlers-Danlos syndrome type VII. (1980) (120)
Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs) (2016) (120)
Preactivation of human MSCs with TNF-α enhances tumor-suppressive activity. (2012) (119)
Medical therapies with adult stem/progenitor cells (MSCs): A backward journey from dramatic results in vivo to the cellular and molecular explanations (2012) (119)
Affinity column purification of protocollagen proline hydroxylase from chick embryos and further characterization of the enzyme. (1973) (118)
A method for the simultaneous measurement of the radioactivity of proline-C14 and hydroxyproline-C14 in biological materials. (1962) (117)
MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs (2014) (117)
TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury (2016) (117)
Mesenchymal stem/stromal cells precondition lung monocytes/macrophages to produce tolerance against allo- and autoimmunity in the eye (2015) (116)
Structure of cDNA clones coding for the entire prepro alpha 1 (III) chain of human type III procollagen. Differences in protein structure from type I procollagen and conservation of codon preferences. (1989) (115)
Biosynthesis of abnormal collagens with amino acid analogues. I. Incorporation of L-azetidine-2-carboxylic acid and cis-4-fluoro-L-proline into protocollagen and collagen. (1969) (114)
A second mutation in the type II procollagen gene (COL2AI) causing stickler syndrome (arthro-ophthalmopathy) is also a premature termination codon. (1993) (113)
The clinical features of homozygous alpha 2(I) collagen deficient osteogenesis imperfecta. (1984) (113)
Implantation of allogenic synovial stem cells promotes meniscal regeneration in a rabbit meniscal defect model. (2012) (113)
Mutations in Collagen Genes as a Cause of Connective-Tissue Diseases (1992) (112)
Gastrointestinal absorption and renal excretion of hydroxyproline peptides. (1962) (112)
Structure of a full-length cDNA clone for the prepro alpha 1(I) chain of human type I procollagen. (1988) (112)
Collagen fibrils in vitro grow from pointed tips in the C- to N-terminal direction. (1990) (112)
Apoptosis of chondrocytes in transgenic mice lacking collagen II. (1997) (111)
Partial isodisomy for maternal chromosome 7 and short stature in an individual with a mutation at the COL1A2 locus. (1992) (111)
Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility. (2001) (111)
Human type I procollagen genes are located on different chromosomes. (1982) (108)
Formation of collagen fibrils in vitro by cleavage of procollagen with procollagen proteinases. (1982) (108)
Sequencing of cDNA from 50 unrelated patients reveals that mutations in the triple-helical domain of type III procollagen are an infrequent cause of aortic aneurysms. (1993) (108)
Mutation analysis of coding sequences for type I procollagen in individuals with low bone density (1994) (108)
Stem cells in the face: tooth regeneration and beyond. (2012) (108)
The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region. (1988) (107)
Structure of a full-length cDNA clone for the prepro alpha 2(I) chain of human type I procollagen. Comparison with the chicken gene confirms unusual patterns of gene conservation. (1988) (105)
Perspectives on the synthesis and application of triple-helical, collagen-model peptides. (1996) (104)
Synthesis of elastin and procallagen by cells from embryonic aorta. Differences in the role of hydroxyproline and the effects of proline analogs on the secretion of the two proteins. (1976) (103)
SYNTHESIS OF HYDROXYPROLINE IN VITRO BY THE HYDROXYLATION OF PROLINE IN A PRECURSOR OF COLLAGEN. (1965) (103)
Genetic linkage analysis of hereditary arthro-ophthalmopathy (Stickler syndrome) and the type II procollagen gene. (1989) (101)
Further evidence for a transport form of collagen. Its extrusion and extracellular conversion to tropocollagen in embryonic tendon. (1971) (100)
Protocollagen proline hydroxylase in normal liver and in hepatic fibrosis. (1969) (100)
The exciting prospects of new therapies with mesenchymal stromal cells. (2017) (99)
A substitution of cysteine for glycine 748 of the alpha 1 chain produces a kink at this site in the procollagen I molecule and an altered N-proteinase cleavage site over 225 nm away. (1988) (99)
Multipotent Stromal Cells Are Activated to Reduce Apoptosis in Part by Upregulation and Secretion of Stanniocalcin‐1 (2009) (98)
Assembly of type I collagen fibrils de novo. Between 37 and 41 degrees C the process is limited by micro-unfolding of monomers. (1988) (98)
Dkk-1-derived Synthetic Peptides and Lithium Chloride for the Control and Recovery of Adult Stem Cells from Bone Marrow* (2005) (98)
Biosynthesis of cartilage procollagen. (1973) (97)
The biosynthesis of basement membrane collagen in embryonic chick lens. I. Delay between the synthesis of polypeptide chains and the secretion of collagen by matrix-free cells. (1972) (95)
Effects of the stereo-configuration of the hydroxyl group in 4-hydroxyproline on the triple-helical structures formed by homogenous peptides resembling collagen. (1976) (95)
Partial purification and characterization of a neutral protease which cleaves the N-terminal propeptides from procollagen. (1978) (94)
Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC1. (2012) (93)
Synthesis of recombinant human procollagen II in a stably transfected tumour cell line (HT1080). (1994) (93)
Synthesis of an altered type III procollagen in a patient with type IV Ehlers-Danlos syndrome. A structural change in the alpha 1(III) chain which makes the protein more susceptible to proteinases. (1985) (92)
Adult Stem Cells, Lung Biology, and Lung Disease (2006) (91)
A SIMPLE METHOD FOR DIFFERENTIAL ASSAY OF TRITIUM AND CARBON-14 IN WATER-SOLUBLE BIOLOGICAL MATERIALS. (1963) (90)
Purification of (14C) protocollagen and its hydroxylation by prolyl-hydroxylase. (1973) (90)
Mesenchymal Stem/Stromal Cells Inhibit the NLRP3 Inflammasome by Decreasing Mitochondrial Reactive Oxygen Species (2014) (90)
Type I procollagen: the gene-protein system that harbors most of the mutations causing osteogenesis imperfecta and probably more common heritable disorders of connective tissue. (1989) (89)
Administration of TSG-6 improves memory after traumatic brain injury in mice (2013) (89)
Transgenic mice that express a mini-gene version of the human gene for type I procollagen (COL1A1) develop a phenotype resembling a lethal form of osteogenesis imperfecta. (1991) (89)
Rat adult stem cells (marrow stromal cells) engraft and differentiate in chick embryos without evidence of cell fusion. (2004) (88)
Purification and partial characterization of the enzyme for the hydroxylation of proline in protocollagen (1967) (88)
Synthesis and physical properties of (hydroxyproline-proline-glycine)10: hydroxyproline in the X-position decreases the melting temperature of the collagen triple helix. (1982) (88)
Growing tips of type I collagen fibrils formed in vitro are near-paraboloidal in shape, implying a reciprocal relationship between accretion and diameter. (1992) (87)
Collagen Synthesis: Localization of Prolyl Hydroxylase in Tendon Cells Detected with Ferritin-Labeled Antibodies (1973) (87)
Thermal stability of the triple helix of type I procollagen and collagen. Precautions for minimizing ultraviolet damage to proteins during circular dichroism studies. (1979) (85)
Complete primary structure of the α1‐chain of human basement membrane (type IV) collagen (1987) (85)
Heterozygous glycine substitution in the COL11A2 gene in the original patient with the Weissenbacher-Zweymüller syndrome demonstrates its identity with heterozygous OSMED (nonocular Stickler syndrome). (1998) (85)
Marrow stromal cells as stem cells for continual renewal of nonhematopoietic tissues and as potential vectors for gene therapy (1998) (84)
Formation of the triple helix of type I procollagen in cellulo. A kinetic model based on cis-trans isomerization of peptide bonds. (1981) (84)
The molecular defect in a nonlethal variant of osteogenesis imperfecta. Synthesis of pro-alpha 2(I) chains which are not incorporated into trimers of type I procollagen. (1983) (82)
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies (2007) (80)
Restriction fragment length polymorphism associated with the pro alpha 2(I) gene of human type I procollagen. Application to a family with an autosomal dominant form of osteogenesis imperfecta. (1983) (80)
Kinetics for the secretion of nonhelical procollagen by freshly isolated tendon cells. (1979) (80)
Inheritance of an RNA splicing mutation (G+ 1 IVS20) in the type III procollagen gene (COL3A1) in a family having aortic aneurysms and easy bruisability: phenotypic overlap between familial arterial aneurysms and Ehlers-Danlos syndrome type IV. (1990) (80)
Structure of cDNA clones coding for human type II procollagen. The alpha 1(II) chain is more similar to the alpha 1(I) chain than two other alpha chains of fibrillar collagens. (1989) (78)
A-2-->G transition at the 3' acceptor splice site of IVS17 characterizes the COL2A1 gene mutation in the original Stickler syndrome kindred. (1996) (78)
A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury. (2004) (78)
Inflammation, fibrosis, and modulation of the process by mesenchymal stem/stromal cells. (2016) (78)
Incorporation of cis-hydroxyproline into protocollagen and collagen. Collagen containing cis-hydroxyproline in place of proline and trans-hydroxyproline is not extruded at a normal rate. (1971) (77)
Human Multipotent Stromal Cells (MSCs) Increase Neurogenesis and Decrease Atrophy of the Striatum in a Transgenic Mouse Model for Huntington's Disease (2010) (77)
Mutation in type II procollagen (COL2A1) that substitutes aspartate for glycine alpha 1-67 and that causes cataracts and retinal detachment: evidence for molecular heterogeneity in the Wagner syndrome and the Stickler syndrome (arthro-ophthalmopathy) (1993) (76)
Increased protocollagen hydroxylase activity in the livers of rats with hepatic fibrosis. (1967) (76)
Formation of interchain disulfide bonds and helical structure during biosynthesis of procollagen by embryonic tendon cells. (1974) (76)
Use of an antisense oligonucleotide to inhibit expression of a mutated human procollagen gene (COL1A1) in transfected mouse 3T3 cells. (1993) (76)
Further proof of the plasticity of adult stem cells and their role in tissue repair (2003) (75)
Formation of collagen fibrils by enzymic cleavage of precursors of type I collagen in vitro. (1984) (75)
Increased steady-state levels of laminin B1 mRNA in kidneys of long-term streptozotocin-diabetic rats. No effect of an aldose reductase inhibitor. (1988) (75)
Pleomorphism in type I collagen fibrils produced by persistence of the procollagen N-propeptide. (1989) (73)
A fourth example suggests that premature termination codons in the COL2A1 gene are a common cause of the Stickler syndrome: analysis of the COL2A1 gene by denaturing gradient gel electrophoresis. (1993) (73)
Partial purification and characterization of protocollagen lysine hydroxylase from chick embryos. (1972) (72)
Ferritin-conjugated antibodies used for labeling of organelles involved in the cellular synthesis and transport of procollagen. (1974) (72)
Three new point mutations in type II procollagen (COL2A1) and identification of a fourth family with the COL2A1 Arg519-->Cys base substitution using conformation sensitive gel electrophoresis. (1995) (72)
Synthesis and processing of a type I procollagen containing shortened pro-alpha 1(I) chains by fibroblasts from a patient with osteogenesis imperfecta. (1983) (71)
The biosynthesis of basement membrane collagen in embryonic chick lens. II. Synthesis of a precursor form by matrix-free cells and a time-dependent conversion to chains in intact lens. (1972) (71)
A single base mutation that substitutes serine for glycine 790 of the alpha 1 (III) chain of type III procollagen exposes an arginine and causes Ehlers-Danlos syndrome IV. (1989) (70)
Temperature-induced post-translational over-modification of type I procollagen. Effects of over-modification of the protein on the rate of cleavage by procollagen N-proteinase and on self-assembly of collagen into fibrils. (1992) (70)
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels (2010) (70)
A Transport Form of Collagen from Embryonic Tendon: Electron Microscopic Demonstration of an NH2-Terminal Extension and Evidence Suggesting the Presence of Cystine in the Molecule (1972) (69)
Inhibitors of collagen biosynthesis as a means of controlling scar formation in tendon injury. (1972) (69)
Synthesis of a shortened pro-alpha 2(I) chain and decreased synthesis of pro-alpha 2(I) chains in a proband with osteogenesis imperfecta. (1983) (69)
Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis. (2007) (69)
Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration (2018) (69)
Strategies for improving animal models for regenerative medicine. (2013) (68)
Expression of human COL1A1 gene in stably transfected HT1080 cells: the production of a thermostable homotrimer of type I collagen in a recombinant system. (1993) (67)
Further characterization of embryonic tendon fibroblasts and the use of immunoferritin techniques to study collagen biosynthesis (1975) (67)
Dissociation of the synthesis of sulphated mucopolysaccharides and the synthesis of collagen in embryonic cartilage. (1966) (67)
A new epidermal growth factor-like domain in the human core protein for the large cartilage-specific proteoglycan. Evidence for alternative splicing of the domain. (1989) (66)
Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral. (1993) (66)
Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. I. Arrest of collagen accumulation in growing chick embryos. (1971) (66)
Studies on protocollagen lysine hydroxylase. Hydroxylation of synthetic peptides and the stoichiometric decarboxylation of -ketoglutarate. (1972) (66)
A simple technique for measuring the specific activity of labeled hydroxyproline in biological materials. (1961) (66)
Identical G+1 to A mutations in three different introns of the type III procollagen gene (COL3A1) produce different patterns of RNA splicing in three variants of Ehlers-Danlos syndrome. IV. An explanation for exon skipping some mutations and not others. (1990) (65)
INTRACELLULAR ACCUMULATION OF PROTOCOLLAGEN AND EXTRUSION OF COLLAGEN BY EMBRYONIC CARTILAGE CELLS (1968) (65)
Single base mutation in the pro alpha 2(I) collagen gene that causes efficient splicing of RNA from exon 27 to exon 29 and synthesis of a shortened but in-frame pro alpha 2(I) chain. (1988) (64)
Kinetics for the secretion of procollagen by freshly isolated tendon cells. (1977) (64)
More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running exercise. (2001) (63)
Are Clinical Trials With Mesenchymal Stem/Progenitor Cells too Far Ahead of the Science? Lessons From Experimental Hematology (2014) (63)
Incorporation of 3,4-dehydroproline into protocollagen and collagen. Limited hydroxylation of proline and lysine in the same polypeptide. (1970) (63)
Biosynthesis of abnormal collagens with amino acid analogues. II. Inability of cartilage cells to extrude collagen polypeptides containing L-azetidine-2-carboxylic acid or cis-4-fluoro-L-proline. (1969) (62)
Oxygen-18 studies on the conversion of proline to collagen hydroxyproline. (1963) (62)
Single base mutation in the type III procollagen gene that converts the codon for glycine 883 to aspartate in a mild variant of Ehlers-Danlos syndrome IV. (1989) (62)
STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation (2019) (61)
Refinement of the chromosome 5p locus for familial calcium pyrophosphate dihydrate deposition disease. (1999) (61)
Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells. (2010) (61)
Helical model of nucleation and propagation to account for the growth of type I collagen fibrils from symmetrical pointed tips: a special example of self-assembly of rod-like monomers. (1992) (61)
Assignment of the human pro alpha 2(I) collagen structural gene (COLIA2) to chromosome 7 by molecular hybridization. (1982) (61)
Reversible commitment to differentiation by human multipotent stromal cells in single-cell-derived colonies. (2008) (61)
Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain (2019) (61)
Incorporation of cis-hydroxyproline into collagen by tendon cells. Failure of the intracellular collagen to assume a triple-helical conformation. (1972) (60)
Interchain disulfide bonds at the COOH-terminal end of procollagen synthesized by matrix-free cells from chick embryonic tendon and cartilage. (1976) (60)
Structural organization of the gene for the alpha 1 chain of human type IV collagen. (1989) (60)
Widely distributed mutations in the COL2A1 gene produce achondrogenesis type II/hypochondrogenesis. (2000) (59)
Stem cells and cell therapies in lung biology and diseases: conference report. (2013) (59)
The Human COL11A2 Gene Structure Indicates that the Gene Has Not Evolved with the Genes for the Major Fibrillar Collagens (*) (1995) (58)
Prevention of collagen deposition following pulmonary oxygen toxicity in the rat by cis-4-hydroxy-L-proline. (1980) (58)
Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides. (1989) (58)
What holds us together? Why do some of us fall apart? What can we do about it? (1998) (58)
Steady-state levels of mRNAs coding for the type IV collagen and laminin polypeptide chains of basement membranes exhibit marked tissue-specific stoichiometric variations in the rat. (1987) (57)
Phenotypic heterogeneity in osteogenesis imperfecta: the mildly affected mother of a proband with a lethal variant has the same mutation substituting cysteine for alpha 1-glycine 904 in a type I procollagen gene (COL1A1). (1990) (57)
Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome (2014) (57)
Genetic causes of aortic aneurysms. Unlearning at least part of what the textbooks say. (1991) (56)
Specific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides. The most effective target sites are clustered in double-stranded regions of the predicted secondary structure for the mRNA. (1994) (56)
A point mutation in a type I procollagen gene converts glycine 748 of the alpha 1 chain to cysteine and destabilizes the triple helix in a lethal variant of osteogenesis imperfecta. (1987) (56)
Intraperitoneally infused human mesenchymal stem cells form aggregates with mouse immune cells and attach to peritoneal organs (2016) (55)
Completion of the intron-exon structure of the gene for human type II procollagen (COL2A1): variations in the nucleotide sequences of the alleles from three chromosomes. (1990) (55)
Mutations in Type 1 Procollagen That Cause Osteogenesis Imperfecta: Effects of the Mutations on the Assembly of Collagen into Fibrils, the Basis of Phenotypic Variations, and Potential Antisense Therapies (1993) (55)
Studies on the intracellular localization of collagen synthesis in the intact chick embryo. (1962) (55)
Assembly of Collagen Fibrils de Novo from Soluble Precursors: Polymerization and Copolymerization of Procollagen, pN-Collagen, and Mutated Collagens (1994) (55)
Procollagen-a precursor form of collagen. (1973) (54)
Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer (2001) (54)
Phase-directed therapy: TSG-6 targeted to early inflammation improves bleomycin-injured lungs. (2014) (54)
A mutation in the pro alpha 2(I) gene (COL1A2) for type I procollagen in Ehlers-Danlos syndrome type VII: evidence suggesting that skipping of exon 6 in RNA splicing may be a common cause of the phenotype. (1991) (53)
Influence of Scurvy and Lathyrism (Odoratism) on Hydroxyproline Excretion (1961) (53)
Ascorbate increases the synthesis of procollagen hydroxyproline by cultured fibroblasts from chick embryo tendons without activation of prolyl hydroxyla. (1975) (53)
ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride–induced hepatic fibrosis in mice (2007) (52)
Nuclease S1 mapping of a homozygous mutation in the carboxyl-propeptide-coding region of the pro alpha 2(I) collagen gene in a patient with osteogenesis imperfecta. (1984) (52)
Procollagen N-proteinase. Properties of the enzyme purified from chick embryo tendons. (1982) (52)
Crystal induced inflammation in canine joints. 3. Evidence against bradykinin as a mediator of inflammation. (1966) (52)
Intracellular hydroxylation of non-helical protocollagen to form triple-helical procollagen and subsequent secretion of the molecule. (1974) (52)
A defect in the structure of type I procollagen in a patient who had osteogenesis imperfecta: excess mannose in the COOH-terminal propeptide. (1980) (52)
Molecular heterogeneity in the mild autosomal dominant forms of osteogenesis imperfecta. (1984) (52)
Further hydroxylation of lysyl residues in collagen by protocollagen lysyl hydroxylase in vitro. (1973) (51)
Osteogenesis imperfecta: phenotypic heterogeneity, protein suicide, short and long collagen. (1984) (51)
SOURCE OF THE ELEVATED SERUM ALKALINE PHOSPHATASE ACTIVITY IN BILIARY OBSTRUCTION: STUDIES UTILIZING ISOLATED LIVER PERFUSION. (1964) (51)
Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system. (2000) (51)
The biosynthesis of basement membrane collagen in embryonic chick lens. 3. Intracellular formation of the triple helix and the formation of aggregates through disulfide bonds. (1973) (51)
Influence of cortisol on the synthesis of sulfated mucopolysaccharides and collagen in chick embryos. (1967) (51)
Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner. (2017) (51)
Partial characterization of a low molecular weight human collagen that undergoes alternative splicing. (1987) (51)
A heterozygous defect for structurally altered pro-alpha 2 chain of type I procollagen in a mild variant of osteogenesis imperfecta. The altered structure decreases the thermal stability of procollagen and makes it resistant to procollagen N-proteinase. (1984) (50)
Human COL9A1 and COL9A2 genes. Two genes of 90 and 15 kb code for similar polypeptides of the same collagen molecule. (1998) (50)
Precursors of the hydroxyproline and ketoproline in actinomycin. (1962) (50)
Unique characteristics of human mesenchymal stromal/progenitor cells pre-activated in 3-dimensional cultures under different conditions. (2014) (50)
Detection of single-base mutations by reaction of DNA heteroduplexes with a water-soluble carbodiimide followed by primer extension: application to products from the polymerase chain reaction (1990) (50)
Univariate and bivariate variance component linkage analysis of a whole-genome scan for loci contributing to bone mineral density (2005) (49)
Biosynthesis of cartilage procollagen. Influence of chain association and hydroxylation of prolyl residues on the folding of the polypeptides into the triple-helical conformation. (1974) (49)
Kinetic patterns of protocollagen hydroxylase and further studies on the polypeptide substrate. (1968) (48)
Partial characterization of protocollagen from embryonic cartilage. (1967) (48)
Location of xylosyltransferase in the cisternae of the rough endoplasmic reticulum of embryonic cartilage cells. (1984) (48)
Assembly of Type I Collagen Fibrils de Novo by the Specific Enzymic Cleavage of pC Collagen (1990) (48)
Soliciting strategies for developing cell-based reference materials to advance mesenchymal stromal cell research and clinical translation. (2014) (47)
Hydroxylation of (X-Pro-Gly)n by protocollagen proline hydroxylase. Effect of chain length, helical conformation and amino acid sequence in the substrate. (1972) (46)
Comparison of the anti-inflammatory effects of induced pluripotent stem cell-derived and bone marrow-derived mesenchymal stromal cells in a murine model of corneal injury. (2017) (46)
Hydroxylation of lysine in a polypeptide precursor of collagen. (1966) (46)
Bone fragility in transgenic mice expressing a mutated gene for type I procollagen (COL1A1) parallels the age‐dependent phenotype of human osteogenesis imperfecta (1995) (46)
Synthesis and secretion of under-hydroxylated procollagen at various temperatures by cells subject to temporary anoxia. (1974) (46)
Collagen synthesis and collagenase activity in dermal fibroblasts from patients with diabetes and digital sclerosis. (1985) (46)
Molecular basis of osteogenesis imperfecta and related disorders of bone. (1994) (45)
Substitution of aspartate for glycine 1018 in the type III procollagen (COL3A1) gene causes type IV Ehlers-Danlos syndrome: the mutated allele is present in most blood leukocytes of the asymptomatic and mosaic mother. (1992) (45)
Phenotypic variability and incomplete penetrance of spontaneous fractures in an inbred strain of transgenic mice expressing a mutated collagen gene (COL1A1). (1994) (45)
Gene structure for the alpha 1 chain of a human short-chain collagen (type XIII) with alternatively spliced transcripts and translation termination codon at the 5' end of the last exon. (1988) (45)
Identification of the HSPB4/TLR2/NF-κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea (2012) (44)
Self-assembly into fibrils of collagen II by enzymic cleavage of recombinant procollagen II. Lag period, critical concentration, and morphology of fibrils differ from collagen I. (1994) (44)
Self-assembly into fibrils of a homotrimer of type I collagen. (1992) (44)
Thermal stability of type I and type III procollagens from normal human fibroblasts and from a patient with osteogenesis imperfecta. (1980) (43)
Partial purification of a procollagen C-proteinase. Inhibition by synthetic peptides and sequential cleavage of type I procollagen. (1982) (43)
Oxygen-18 studies on the conversion of proline to hydroxyproline. (1962) (42)
Retention of nonhelical procollagen containing cis-hydroxyproline in rough endoplasmic reticulum (1975) (42)
Regeneration after nerve transection: effect of inhibition of collagen synthesis. (1974) (42)
Altered helical structure of a homotrimer of alpha 1(I)chains synthesized by fibroblasts from a variant of osteogenesis imperfecta. (1985) (42)
The biosynthesis of collagen and its disorders (second of two parts). (1979) (42)
Formation of enzyme-substrate complexes with protocollagen proline hydroxylase and large polypeptide substrates. (1969) (42)
Role of iron in the synthesis of collagen in connective tissue. (1971) (42)
A 19-base pair deletion in the pro-alpha 2(I) gene of type I procollagen that causes in-frame RNA splicing from exon 10 to exon 12 in a proband with atypical osteogenesis imperfecta and in his asymptomatic mother. (1988) (42)
In Vitro Macrophage Assay Predicts the In Vivo Anti-inflammatory Potential of Exosomes from Human Mesenchymal Stromal Cells (2018) (42)
Osteopenia in 37 Members of Seven Families: Analysis Based on a Model of Dominant Inheritance (1996) (41)
Collagen degradation and the response to parathyroid extract in the intact rhesus monkey. (1967) (41)
Stem cells and cell therapies in lung biology and lung diseases. (2011) (41)
Human stem/progenitor cells from bone marrow enhance glial differentiation of rat neural stem cells: a role for transforming growth factor β and Notch signaling. (2011) (41)
Mutations that substitute serine for glycine alpha 1-598 and glycine alpha 1-631 in type I procollagen. The effects on thermal unfolding of the triple helix are position-specific and demonstrate that the protein unfolds through a series of cooperative blocks. (1990) (40)
Adult stem cells, lung biology, and lung disease. NHLBI/Cystic Fibrosis Foundation Workshop. (2006) (40)
Primary and secondary effects of ascorbate on procollagen synthesis and protein synthesis by primary cultures of tendon fibroblasts. (1976) (40)
Segment-long-spacing aggregates and isolation of COOH-terminal peptides from type I procollagen. (1976) (40)
Synthesis of elastin in aortas from chick embryos. Conversion of newly secreted elastin to cross-linked elastin without apparent proteolysis of the molecule. (1977) (40)
Complete sequence of the 23-kilobase human COL9A3 gene. Detection of Gly-X-Y triplet deletions that represent neutral variants. (1999) (39)
A type I collagen with substitution of a cysteine for glycine-748 in the alpha 1(I) chain copolymerizes with normal type I collagen and can generate fractallike structures. (1991) (39)
Relearning the Lessons of Genomic Stability of Human Cells During Expansion in Culture: Implications for Clinical Research (2012) (39)
INCORPORATION OF SULFATE AND THE SYNTHESIS OF COLLAGEN BY CULTURES OF EMBRYONIC CHONDROCYTES. (1964) (38)
Protocollagen proline hydroxylase from Ascaris lumbricoides. (1969) (38)
Mutation in the COL2A1 gene in a patient with hypochondrogenesis. Expression of mutated COL2A1 gene is accompanied by expression of genes for type I procollagen in chondrocytes. (1994) (38)
An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases. (2015) (38)
Does bound water contribute to the stability of collagen? (1998) (38)
Bone turnover and type I collagen C-telopeptide isomerization in adult osteogenesis imperfecta: associations with collagen gene mutations. (2009) (37)
Conservation of the sizes of 53 introns and over 100 intronic sequences for the binding of common transcription factors in the human and mouse genes for type II procollagen (COL2A1). (1995) (37)
Methods and protocols. Preface. (2008) (37)
A rapid assay for 14C-labeled hydroxylysine in collagen and related materials. (1969) (37)
A to G polymorphism in ELN gene. (1991) (37)
Rate of helix formation by intracellular procollagen and protocollagen. Evidence for a role for disulfide bonds. (1973) (36)
Stanniocalcin-1 rescued photoreceptor degeneration in two rat models of inherited retinal degeneration. (2012) (36)
High levels of expression of a minigene version of the human pro alpha 1 (I) collagen gene in stably transfected mouse fibroblasts. Effects of deleting putative regulatory sequences in the first intron. (1991) (35)
Intracellular Pool of Unhydroxylated Polypeptide Precursors of Collagen (1967) (35)
beta-Aminopropionitrile prevents bleomycin-induced pulmonary fibrosis in the hamster. (1982) (35)
Titration and melting curves of the collagen-like triple helices formed from (Pro-Pro-Gly) in aqueous solution. (1970) (35)
Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. II. Morphological and physical properties of collagen containing the analogue. (1971) (35)
Cross‐talk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPS‐stimulated cocultures: the MSCs are activated to secrete prostaglandin E2 (2011) (35)
An ultrastructural, microanalytical, and spectroscopic study of bone from a transgenic mouse with a COL1.A1 pro-alpha-1 mutation. (1994) (35)
Defects in the processing of procollagen to collagen are demonstrable in cultured fibroblasts from patients with the Ehlers-Danlos and osteogenesis imperfecta syndromes. (1986) (35)
Osteogenesis imperfecta. A model for genetic causes of osteoporosis and perhaps several other common diseases of connective tissue. (1988) (35)
Assembly in vitro of thin and thick fibrils of collagen II from recombinant procollagen II. The monomers in the tips of thick fibrils have the opposite orientation from monomers in the growing tips of collagen I fibrils. (1996) (35)
Cleavage of type I procollagen by C- and N-proteinases is more rapid if the substrate is aggregated with dextran sulfate or polyethylene glycol. (1994) (35)
Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model (2012) (34)
Collagen II containing a Cys substitution for arg-alpha1-519. Homotrimeric monomers containing the mutation do not assemble into fibrils but alter the self-assembly of the normal protein. (1997) (34)
Detection of mismatched bases in double stranded DNA by gel electrophoresis (1995) (34)
Migratory response of mesenchymal stem cells to macrophage migration inhibitory factor and its antagonist as a function of colony-forming efficiency (2009) (34)
Mesenchymal Stem Cells. Methods and Protocols. (2010) (34)
Potential use of marrow stromal cells as therapeutic vectors for diseases of the central nervous system. (2000) (34)
Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. (1981) (33)
Mutations in collagen genes. Consequences for rare and common diseases. (1985) (33)
Type I procollagen N-proteinase from whole chick embryos. Cleavage of a homotrimer of pro-alpha 1(I) chains and the requirement for procollagen with a triple-helical conformation. (1985) (33)
Aregenerative anemia associated with benign thymoma. (1958) (33)
Hydroxylation of proline and lysine in protocollagen involves two separate enzymatic sites. (1969) (33)
Cleavage of type I and type II procollagens by type I/II procollagen N-proteinase. Correlation of kinetic constants with the predicted conformations of procollagen substrates. (1988) (32)
Hydroxylation of proline after the release of proline-rich polypeptides from ribosomal complexes during uninhibited collagen biosynthesis. (1967) (32)
A model for the triple-helical structure of (Pro-Hyp-Gly)10 involving a cis peptide bond and inter-chain hydrogen-bonding to the hydroxyl group of hydroxyproline. (1973) (32)
Deletion of a large domain in recombinant human procollagen II does not alter the thermal stability of the triple helix. (1993) (31)
Effect of polymer size on the inhibition of protocollagen proline hydroxylase by polyproline II. (1969) (31)
Detection of sequence variants in the gene for human type II procollagen (COL2A1) by direct sequencing of polymerase chain reaction‐amplified genomic DNA (1992) (31)
Tissue-specific Expression of the Gene for Type I Procollagen (COL1A1) in Transgenic Mice (1995) (31)
Mutations that alter the primary structure of type I procollagen have long-range effects on its cleavage by procollagen N-proteinase. (1989) (31)
Expression of a human cartilage procollagen gene (COL2A1) in mouse 3T3 cells. (1991) (31)
Antibodies to Chick‐Tendon Procollagen (1974) (31)
STUDIES WITH PROLINE-3,4,-H3 ON THE HYDROXYLATION OF PROLINE DURING COLLAGEN SYNTHESIS IN CHICK EMBRYOS. (1964) (30)
Effect of cycloheximide on collagen biosynthesis as evidence for a post-ribosomal site for the hydroxylation of proline. (1967) (30)
Hydroxylation of peptide-bound proline and lysine before and after chain completion of the polypeptide chains of procollagen. (1974) (30)
Collagen diseases and the biosynthesis of collagen. (1977) (30)
Copolymerization of normal type I collagen with three mutated type I collagens containing substitutions of cysteine at different glycine positions in the alpha 1 (I) chain. (1992) (29)
Substitution of aspartic acid for glycine at position 310 in type II collagen produces achondrogenesis II, and substitution of serine at position 805 produces hypochondrogenesis: analysis of genotype-phenotype relationships. (1995) (29)
The synthetic polytripeptides (Pro-Pro-Gly)10 and (Pro-Pro-Gly)20 form micro-crystalline structures similar to segmental structures formed by collagen. (1971) (29)
Cadmium ions inhibit procollagen C-proteinase and cupric ions inhibit procollagen N-proteinase. (1994) (29)
A single base mutation that converts glycine 907 of the alpha 2(I) chain of type I procollagen to aspartate in a lethal variant of osteogenesis imperfecta. The single amino acid substitution near the carboxyl terminus destabilizes the whole triple helix. (1989) (29)
The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1 (1996) (29)
Histamine Receptor H1 and Dermatopontin: New Downstream Targets of the Vitamin D Receptor (2007) (29)
Substitution of serine for alpha 1(I)-glycine 844 in a severe variant of osteogenesis imperfecta minimally destabilizes the triple helix of type I procollagen. The effects of glycine substitutions on thermal stability are either position of amino acid specific. (1989) (29)
Human immunodeficiency virus type 1 Vpr alters bone marrow cell function. (1999) (28)
Mitochondria to the rescue (2012) (28)
Structure of protocollagen proline hydroxylase from chick embryos. (1973) (28)
Oligopeptides with the sequences ala-pro-gly and gly-pro-gly as substrates or inhibitors for protocollagen proline hydroxylase. (1969) (28)
HYDROXYLATION OF PROLINE IN PARTICULATE FRACTIONS FROM CARTILAGE. (1965) (28)
Quantitative assay for hydroxylysine in protein hydrolyzates. (1971) (28)
Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells. (2009) (28)
An effect of puromycin on the synthesis of collagen by embryonic cartilage in vitro. (1966) (28)
Incorporation of proline analogs into procollagen. Assay for replacement of imino acids by cis-4-hydroxy-L-proline and cis-4-fluoro-L-proline. (1977) (28)
Sequential steps in the synthesis of hydroxylysine and the glycosylation of hydroxylysine during the biosynthesis of collagen. (1969) (27)
MYELIN SYNTHESIS IN PERIPHERAL NERVE IN VITRO: SULPHATIDE INCORPORATION REQUIRES A TRANSPORT LIPOPROTEIN 1, 2, 3 (1972) (27)
Sequence and genomic organization of the human G-protein Golfα gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia (2000) (27)
Inhibitors of procollagen N-protease. Synthetic peptides with sequences similar to the cleavage site in the pro alpha 1(I) chain. (1980) (27)
Partial rescue of a lethal phenotype of fragile bones in transgenic mice with a chimeric antisense gene directed against a mutated collagen gene. (1994) (27)
Catabolism and excretion of free hydroxyproline in infancy. (1967) (26)
Adult stem cells gradually come of age (2002) (26)
Mutations in Osteogenesis Imperfecta Leading to the Synthesis of Abnormal Type I Procollagens (1985) (26)
Denatured collagen from the cuticle of Ascaris lumbricoides as a substrate for protocollagen proline hydroxylase. (1968) (26)
Collagen: Gene Structure (2003) (26)
Drosha regulates hMSCs cell cycle progression through a miRNA independent mechanism. (2011) (25)
The complete cDNA coding sequence for the mouse proα1(I) chain of type I procollagen (1995) (25)
Data against a Common Assumption: Xenogeneic Mouse Models Can Be Used to Assay Suppression of Immunity by Human MSCs. (2017) (25)
Amplification of Coronary Arteriogenic Capacity of Multipotent Stromal Cells by Epidermal Growth Factor (2009) (25)
A human COL2A1 gene with an Arg519Cys mutation causes osteochondrodysplasia in transgenic mice. (2004) (25)
Prolyl hydroxylase activity in L-929 fibroblasts incubated with and without ascorbate (1976) (25)
Enzymatic synthesis of hydroxyproline by the hydroxylation of poly(L-propyl-glycyl-L-prolyl). (1967) (24)
Characterization of type I procollagen N-proteinase from fetal bovine tendon and skin. Purification of the 500-kilodalton form of the enzyme from bovine tendon. (1994) (24)
Defining the probability that a cell therapy will produce a malignancy. (2010) (24)
Polymerization of pNcollagen I and copolymerization of pNcollagen I with collagen I. A kinetic, thermodynamic, and morphologic study. (1992) (24)
Hydroxylation of (Pro-Pro-Gly)5 and (Pro-Pro-Gly)10 by prolyl hydroxylase. Evidence for an asymmetric active site in the enzyme. (1977) (24)
G to A polymorphism in exon 31 of the COL3A1 gene. (1990) (24)
Identification of collagen in synovial fluid. (1969) (24)
Novel object recognition in Apoe −/− mice improved by neonatal implantation of wild-type multipotential stromal cells (2006) (23)
A single base mutation in the type II procollagen gene (COL2A1) that converts glycine α1‐247 to serine in a family with late‐onset spondyloepiphyseal dysplasia (1994) (22)
Asymmetry in the hydroxylation of (Pro-Pro-Gly) 5 by protocollagen proline hydroxylase. (1971) (22)
Isolation of unhydroxylated type I procollagen folding of the protein in vitro. (1981) (22)
PUROMYCIN INHIBITION OF COLLAGEN SYNTHESIS AS EVIDENCE FOR A RIBOSOMAT OR POST-RIBOSOMAL SITE FOR THE HYDROXYLATION OF PROLINE. (1964) (22)
Can mutated genes cause common osteoarthritis? (1997) (22)
Exclusion of COL1A1, COL1A2, and COL3A1 genes as candidate genes for Ehlers-Danlos syndrome type I in one large family (1991) (22)
An interpretation of the action of psychotropic drugs. (1958) (22)
Stanniocalcin-1 attenuates ischemic cardiac injury and response of differentiating monocytes/macrophages to inflammatory stimuli. (2016) (22)
Stanniocalcin-1 Regulates Extracellular ATP-Induced Calcium Waves in Human Epithelial Cancer Cells by Stimulating ATP Release from Bystander Cells (2010) (22)
Anti-inflammatory protein tumor necrosis factor-α-stimulated protein 6 (TSG-6) promotes early gingival wound healing: an in vivo study. (2015) (22)
Inhibition of scar formation by the proline analog cis-hydroxyproline☆ (1972) (22)
Two new recurrent nucleotide mutations in the COL1A1 gene in four patients with osteogenesis imperfecta: About one‐fifth are recurrent (1997) (22)
Large introns in the 3' end of the gene for the pro alpha 1 (IV) chain of human basement membrane collagen. (1986) (22)
Mutations in type I procollagen genes that cause osteogenesis imperfecta. (1990) (22)
The triple helix in equilibrium with coil conversion of collagen-like polytripeptides in aqueous and nonaqueous solvents. Comparison of the thermodynamic parameters and the binding of water to (L-Pro-L-Pro-Gly)n and (L-Pro-L-Hyp-Gly)n. (1977) (21)
Complete primary structure of the alpha 1-chain of human basement membrane (type IV) collagen. (1987) (21)
EFFECTS OF HYDROCORTISONE ON THE SYNTHESIS OF SULPHATED MUCOPOLYSACCHARIDES AND COLLAGEN IN CHICK EMBRYOS. (1963) (21)
Sequential hydroxylation of lysine and glycosylation of hydroxylysine during the biosynthesis of collagen in isolated cartilage. (1968) (21)
Specific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides (1994) (21)
Use of Differentiating Adult Stem Cells (Marrow Stromal Cells) to Identify New Downstream Target Genes for Transcription Factors (2006) (21)
Addition of mannose to both the amino- and carboxy-terminal properties of type II procollagen occurs without formation of a triple helix. (1978) (21)
Human mesenchymal stromal cells (MSCs) reduce neointimal hyperplasia in a mouse model of flow-restriction by transient suppression of anti-inflammatory cytokines. (2011) (21)
Mass spectrometric gene diagnosis of one-base substitution from polymerase chain reaction amplified human DNA. (1997) (21)
Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1). (1996) (20)
Targeting gene therapy for osteogenesis imperfecta. (2004) (20)
PvuII polymorphism at the COL1A2 locus. (1990) (20)
Fundamentals of Culture and Characterization of Mesenchymal Stem/Progenitor Cells (MSCs) from Bone Marrow Stroma (2007) (20)
Procollagen polypeptides containing cis-4-hydroxy-L-proline are overglycosylated and secreted as nonhelical pro-gamma-chains. (1978) (20)
Collagen II containing a Cys substitution for Arg-alpha1-519. Analysis by atomic force microscopy demonstrates that mutated monomers alter the topography of the surface of collagen II fibrils. (1999) (20)
Purification and partial characterization of the type II procollagen synthesized by embryonic cartilage cells. (1977) (20)
Concanavalin A binds of purified prolyl hydroxylase and partially inhibits its enzymic activity. (1976) (19)
Synthesis of an elastin component of molecular weight about 70,000 by polysomes from chick embryo aortas. (1978) (19)
Labeled antibodies to protocollagen proline hydroxylase from chick embryos for intracellular localization of the enzyme. (1972) (19)
Assignment of the human collagen α1(XIII) chain gene (COL13A1) to the q22 region of chromosome 10 (1989) (19)
A cDNA cassette system for the synthesis of recombinant procollagens. Variants of procollagen II lacking a D-period are secreted as triple-helical monomers. (1997) (19)
Detection and location of single-base mutations in large DNA fragments by immunomicroscopy. (1989) (19)
Synthesis of Collagen (1962) (18)
Studies on the synthesis and intracellular accumulation of protocollagen in organ culture of embryonic cartilage. (1968) (18)
Characterization of the precursor forms of the 1 and 2 chains of collagen from matrix-free tendon cells. (1972) (18)
Posttranslational enzymes in the biosynthesis of collagen: extracellular enzymes. (1982) (18)
The hydroxylation of proline to hydroxyproline during the synthesis of collagen in chick embryos. (1962) (17)
Isolation and partial characterization of the amino-terminal propeptide of type II procollagen from chick embryos. (1982) (17)
Completion of the last half of the structure of the human gene for the Pro alpha 1 (I) chain of type I procollagen (COL1A1). (1991) (17)
Substitution of arginine for glycine at position 154 of the alpha 1 chain of type I collagen in a variant of osteogenesis imperfecta: comparison to previous cases with the same mutation. (1994) (17)
Somatic cell mosaicism: another source of phenotypic heterogeneity in nuclear families with osteogenesis imperfecta. (1993) (17)
A sequence polymorphism in the 3′-nontranslated region of the proα1 chain of type I procollagen (1990) (17)
Transcription of Human Type I Collagen Genes. Variation in the Relative Rates of Transcription of the Proα1 and Proα2 Genes (1989) (17)
Scalable Production of a Multifunctional Protein (TSG-6) That Aggregates with Itself and the CHO Cells That Synthesize It (2016) (16)
C to T polymorphism in exon 33 of the COL3A1 gene. (1991) (16)
iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers (2017) (15)
Genetic diseases of connective tissues in animals. (1987) (15)
Aggregation of a type I collagen precursor containing N-terminal propeptides. (1983) (14)
Hydroxyprolinemia and increased excretion of free hydroxyproline in early infancy. (1966) (14)
Direct sequencing of PCR products derived from cDNAs for the proα1 and proα2 chains of type I procollagen as a screening method to detect mutations in patients with osteogenesis imperfecta (1996) (14)
Type II collagen and avascular necrosis of the femoral head. (2005) (14)
Comparison of poly-L-proline I and II as inhibitors of protocollagen hydroxylase. (1967) (14)
The genetic trail of osteoporosis. (1998) (14)
Comparison of the NH2-Terminal sequences of chick Type I preprocollagen chains synthesized in an nRNA-dependent reticulocyte lysate. (2005) (13)
The intracellular biosynthesis of collagen. Some possible implications for diseases of bone and other connective tissues. (1969) (13)
Arg519‐Cys Mutation in COL2A1: Evidence for Multiple Founders a (1996) (13)
Effects of long-term diabetes and galactosaemia upon lens and retinal mRNA levels in the rat. (1990) (13)
Use of an automated workstation to facilitate PCR amplification, loading agarose gels and sequencing of DNA templates. (1993) (13)
Substitutions for glycine alpha 1-637 and glycine alpha 2-694 of type I procollagen in lethal osteogenesis imperfecta. The conformational strain on the triple helix introduced by a glycine substitution can be transmitted along the helix. (1991) (13)
Sequential cleavage of type I procollagen by procollagen N-proteinase. An intermediate containing an uncleaved pro alpha 1(I) chain. (1985) (13)
Inhibition of collagen synthesis by the proline analogue cis-4-hydroxyproline. (1973) (12)
Recombinant DNA and collagen research. Is amino acid sequencing obsolete? Can we study diseases involving collagen by analysis of the genes? (1980) (12)
Stanniocalcin-1 Rescued Photoreceptor Degeneration in Two Rat Models of Inherited Retinal Degeneration. (2012) (12)
Substitution of cysteine for glycine-alpha 1-691 in the pro alpha 1(I) chain of type I procollagen in a proband with lethal osteogenesis imperfecta destabilizes the triple helix at a site C-terminal to the substitution. (1991) (12)
Temperature sensitivity of aberrant RNA splicing with a mutation in theG+5 position of intron 37 of the gene for type III procollagen from a patient with Ehlers–Danlos syndrome type IV (1993) (12)
Transfer of puromycin-containing polypeptides through the plasma membrane of cartilage cells synthesizing collagen. (1967) (12)
The mouse col11a2 gene. Some transcripts from the adjacent rxr-beta gene extend into the col11a2 gene. (1996) (11)
ABCA12 Is a Major Causative Gene for Non-Bullous Congenital Ichthyosiform Erythroderma (2009) (11)
A 1,064 bp fragment from the promoter region of the Col11a2 gene drives lacZ expression not only in cartilage but also in osteoblasts adjacent to regions undergoing both endochondral and intramembranous ossification in mouse embryos. (1998) (11)
The gene for the alpha 1(IV) chain of human type IV procollagen: the exon structures do not coincide with the two structural subdomains in the globular carboxy‐terminus of the protein. (1986) (11)
A 15 base-pair AT-rich variable number tandem repeat in the type III procollagen gene (COL3A1) as an informative marker for 2q31-2q32.3. (1992) (11)
Structure and Helical Stability of a Modified Procollagen Synthesized in the Presence of 3,4-Dehydroproline A Decrease in Imino Acid Content Suggesting that the Analog Increases the Error Rate of Translation of Proline Codons (1982) (11)
Electron microscopy of protocollagen proline hydroxylase from chick embryos. (1970) (11)
Heritable osteoarthritis. Diagnosis and possible modes of cell and gene therapy. (1999) (11)
How does a skin fibroblast make type I collagen fibers? (1982) (11)
Two cysteine substitutions in procollagen I: a glycine replacement near the N-terminus of alpha 1(I) chain causes lethal osteogenesis imperfecta and a glycine replacement in the alpha 2(I) chain markedly destabilizes the triple helix. (1993) (10)
iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers (2017) (10)
Self-assembly of collagen I from a proband homozygous for a mutation that substituted serine for glycine at position 661 in the alpha 2(I) chain. Possible relationship between the effects of mutations on critical concentration and the severity of the phenotype. (1994) (10)
Variations in the glycosylation of the collagen synthesized by chick embryo cartilage. Effects of development and several hormones. (1970) (10)
A simple and efficient enzymatic method for covalent attachment of DNA to cellulose. Application for hybridization-restriction analysis and for in vitro synthesis of DNA probes. (1986) (10)
Use of R-loop mapping for the assessment of human collagen mutations. (1986) (10)
Effects of Mutations that Change Primary Structure of Collagen on the Self-Assembly of the Protein into Fibrils (1989) (10)
Mutations in Human Procollagen Genes (1990) (10)
PCR detection of a HindIII polymorphism in the human gene for type II procollagen (COL2A1). (1991) (9)
Procollagen Processing Control of Type I Collagen Fibril Assembly (1989) (9)
Robotic automation of dideoxyribonucleotide sequencing reactions. (1994) (9)
A recombinant homotrimer of type I procollagen that lacks the central two D-periods. The thermal stability of the triple helix is decreased by 2 to 4 degrees C. (1997) (9)
Mineral changes in a transgenic mouse model for osteogenesis imperfecta. (1996) (9)
Arg519-Cys-associated haplotype in ice-landic family suggests early origin of this mutation (1996) (9)
Perspectives on the Synthesis and Application of Triple‐Helical, Collagen‐Model Peptides (2010) (9)
Targeted insertions of two exogenous collagen genes into both alleles of their endogenous loci in cultured human cells: the insertions are directed by relatively short fragments containing the promoters and the 5' ends of the genes. (1994) (8)
Expression of type I procollagen genes. (1988) (8)
Characterization of human type II procollagen and collagen-specific antibodies and their application to the study of human type II collagen processing and ultrastructure. (1997) (8)
Synthesis and conformational properties of a recombinant C-propeptide of human type III procollagen. (1997) (8)
Hopkins Memorial Medal lecture. Pleasant surprises en route from the biochemistry of collagen to attempts at gene therapy. (1999) (8)
Kinetics of the incorporation of tropoelastin into elastic fibers in embryonic chick aorta. (1982) (8)
Demonstration by immunofluorescence that the same cells from chick embryo aortas synthesize elastin and collagen types I and III. (1980) (8)
Use of conformation sensitive gel electrophoresis to detect single‐base changes in the gene for COL10A1 (1998) (8)
Synthesis of type I procollagen: formation of interchain disulfide bonds before complete hydroxylation of the protein. (1981) (8)
A new 500-kDa form of type I procollagen N-proteinase from chick embryo tendons. (1992) (8)
Lag between incorporation of proline into protocollagen and synthesis of hydroxyproline during collagen biosynthesis in vitro and in vivo. (1971) (7)
Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs) (2008) (7)
New targets for osteoporosis. (2012) (7)
Erratum: Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice (Proceedings of the National Academy of Sciences of the United States of America (December 13, 2005) 102, 50 (18171-18176) DOI: 10.1073/pnas.0508945102) (2006) (7)
Hydroxyprolinemia as an illustration of nonessential enzymes in man. (1970) (7)
Iron-containing metallocenes as active site directed inhibitors of the proteinase that cleaves the NH2-terminal propeptides from type I procollagen. (1986) (7)
Presence of Translatable mRNA for Proα2(I) Chains in Fibroblasts from a Patient with Osteogenesis Imperfecta whose Type I Collagen does not Contain α2(I) Chains (1984) (7)
Relative transcription rates and mRNA levels for the two chains of type I procollagen. (1987) (7)
Efficient DNA sequencing on microtiter plates using dried reagents and Bst DNA polymerase. (1993) (7)
Further proof for an unpopular concept: a single cell from bone marrow can serve as a stem cell for both hematopoiesis and osteogenesis. (2013) (7)
Intraduodenal hydrolysis of gelatin as a measure of protein digestion in normal subjects and in patients with malabsorption syndromes. (1968) (6)
Prolyl 4-Hydroxylase from Human Placenta. Simultaneous Isolation of Immunoglobulin G which Binds to Ascaris Cuticle Collagen (1982) (6)
G to A polymorphism in exon 45 of the COL1A1 gene. (1991) (6)
Genetic defects of collagen. (1986) (6)
Increased expression of the gene for the pro alpha 1(IV) chain of basement-membrane procollagen in cultured skin fibroblasts from two variants of osteogenesis imperfecta. (1989) (6)
The A and B fragments of normal type I procollagen have a similar thermal stability to proteinase digestion but are selectively destabilized by structural mutations. (1987) (6)
The biosynthesis of collagen. 3. (1972) (5)
Rapidly Self-Renewing Human Multipotent Marrow Stromal Cells (hMSC) Express Sialyl Lewis X and Actively Adhere to Arterial Endothelium in a Chick Embryo Model System (2014) (5)
Mutations in Collagen Genes as a Cause of Rare and Perhaps Common Diseases of Connective Tissue (1991) (5)
Enhanced In Situ Detection of β-Glucuronidase Activity in Murine Tissue (1999) (5)
Marrow stromal cells as stem cells for continual renewal of nonhematopoietic tissues and as potential vectors for gene therapy. (1998) (5)
Antibodies to chick-tendon procollagen. Affinity purification with the isolated disulfide-linded NH2-terminal extensions and reactivity with a component in embryonic serum. (1974) (5)
Gene families of collagen and other proteins : proceedings of a conference held at the College of Medicine and Dentistry of New Jersey--Rutgers Medical School, Piscataway, New Jersey, U.S.A., April 27-May 2, 1980 (1980) (5)
An anticonvulsant effect of monoamine oxidase inhibitors (1959) (5)
A Single Base Mutation in Type III Procollagen That Converts the Codon for Glycine 619 to Arginine in a Family with Familial Aneurysms and Mild Bleeding Tendencies a (1990) (5)
Structure of the Organic Matrix: Collagen Structure (Chemical) (1982) (5)
Transcription of human type I collagen genes. Variation in the relative rates of transcription of the pro alpha 1 and pro alpha 2 genes. (1989) (4)
Use of glutaraldehyde-fixed Escherichia coli cells as a convenient support for radioimmune assays. (1977) (4)
Abnormal Response to Physical Activity in Femurs after Heterozygous Inactivation of One Allele of the Col2a1 Gene for Type II Collagen in Mice (2005) (4)
Deletion of 19 base pairs in intron 13 of the gene for the proα2(I) chain of type-I procollagen (COL1A2) causes exon skipping in a proband with type-I osteogenesis imperfecta (1993) (4)
Interchain Disulphide Bonding in Procollagen from Embryonic Chick Tendon Cells and the Formation of the Triple-Helical Structure (1974) (4)
Present and future research on collagen and genes for collagen. (1980) (4)
Assembly in Vitroof Thin and Thick Fibrils of Collagen II from Recombinant Procollagen II (1996) (4)
DNA polymorphisms in collagen genes: potential use in the study of disease. (1985) (4)
Multipotent Stromal Cells (hMSCs) (2009) (4)
The biosynthesis of collagen and its disorders. Medical progress (1980) (4)
Reply to osteogenesis imperfecta calls for caution (1999) (4)
Ehlers-Danlos type VIIC in human and dermatosparaxis in cattle are caused by mutations in the procollagen i amino-peptidase gene (1998) (3)
Rapid detection of mutations by conformation-sensitive gel electrophoresis. Application to the identification of a fourth family with the Arg519→Cys substitution and three new mutations in the type II procollagen gene (1994) (3)
The complete cDNA coding sequence for the mouse pro alpha 1(I) chain of type I procollagen. (1995) (3)
Presence of translatable mRNA for pro alpha 2(I) chains in fibroblasts from a patient with osteogenesis imperfecta whose type I collagen does not contain alpha 2(I) chains. (1984) (3)
A HindIII polymorphism in the 3' end of the human alpha 1(IV) collagen gene (1987) (3)
Assays of MSCs with microarrays. (2008) (3)
Structure, Properties, and Function of Mineralized Tissue Components Group Report (1982) (3)
Efficient procedure for preparing cosmid libraries from microgram quantities of genomic DNA fragments size fractionated by gel electrophoresis. (1990) (3)
Assignment of the human collagen alpha 1 (XIII) chain gene (COL13A1) to the q22 region of chromosome 10. (1989) (3)
1205: Transplantation of Non-Hematopoietic Adult Bone Marrow Stem Cells Isolated by the P75 Nerve Growth Factor Receptor into the Penis Promotes Functional Recovery of Erectile Function in a Rat Model of Cavernous Nerve Injury (2006) (3)
INTERNALIZED ANTIGENS MARROW AS A POTENTIAL SOURCE OF HEPATIC OVAL CELLS (2004) (3)
Genetic Trail of Osteoporosis: Candidate Genes Versus Genome Screens? Small Families Versus Large Families? (1999) (3)
Is newly-secreted elastin cleaved to a smaller molecule before being incorporated into crosslinked elastin fibers? (1977) (3)
Complete Sequence of the 23-Kilobase Human COL9A3Gene (1999) (3)
A sequence polymorphism in the 3'-nontranslated region of the pro alpha 1 chain of type I procollagen. (1990) (3)
Mesenchymal Stem Cells (2008) (3)
Experimental spinal cord injury models: protective and repair strategies (2001) (3)
Direct sequencing of PCR products derived from cDNAs for the pro alpha 1 and pro alpha 2 chains of type I procollagen as a screening method to detect mutations in patients with osteogenesis imperfecta. (1996) (3)
Electronmicroscopic Localization of Deletions in the Human Pro‐α2(I) Collagen Gene a (1985) (3)
The Intracellular Biosynthesis of Collagen: Some Possible Implications for Diseases of Bone and Other Connective Tissues (1969) (3)
Identification and cloning of integration site of DNA by PCR. (1996) (2)
Separation of Human proα1(I) and proα2(I) Procollagen Chains by Reverse Phase High Performance Liquid Chromatography (1982) (2)
Seminars in medicine of the Beth Israel Hospital, Boston. Mutations in collagen genes as a cause of connective-tissue diseases. (1992) (2)
Transgenic mice with inactivation of the COL11A2 gene demonstrate a minimal cartilage phenotype at birth and at 7 months (1996) (2)
Time to end the stem cell wars (2004) (2)
Mutations in type I procollagen genes : an explanation for brittle bones and a paradigm for other diseases of connective tissue (1990) (2)
Hardly Tendentious--Repairing Like with Like. (2015) (2)
Multipotent Stromal Cells (MSCs) are Activated to Reduce Apoptosis in Part by Upregulation and Secretion of Stanniocalcin-1 (STC-1) (2016) (2)
Transgenic Mice Expressing a Partially (2013) (2)
A long-awaited discovery: hypoxia prevents mouse cells from undergoing spontaneous p53-dependent transformation. (2012) (2)
Effect of cis-4-hydroxy-L-proline on lung mechanics and collagen content of bleomycin-treated hamsters. (1981) (2)
Increase in blood serotonin levels induced by iproniazid in man and rabbits (2004) (2)
Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model (2012) (2)
Enhanced in situ detection of beta-glucuronidase activity in murine tissue. (1999) (2)
Lack of a phenotype in transgenic mice aberrantly expressing COL2A1 mRNA because of highly selective post-transcriptional down-regulation. (2000) (2)
Comparison of conformation sensitive gel electrophoresis with denaturing gradient gel electrophoresis for detection of single-base mutations in PCR products (1996) (2)
Absence of Therapeutic Benefit of the Anti-Inflammatory Protein TSG-6 for Corneal Alkali Injury in a Rat Model (2019) (2)
Utilization of Marrow Stromal Cells for Gene Transfer into the CNS (2003) (2)
A transport form of collagen from embryonic tendon: electron microscopic demonstration of an NH 2 -terminal extension and evidence suggesting the presence of cystine in the molecule (chick embryo-tropocollagen-gel filtration). (1972) (2)
The biosynthesis of collagen. 2. (1972) (2)
TRANSPLANTATION OF NON-HAEMATOPOIETIC ADULT BONE MARROW STEM CELLS ISOLATED BY THE P75 NERVE GROWTH FACTOR INTO THE PENIS PROMOTES RECOVERY OF ERECTILE FUNCTION IN A RAT MODEL OF CAVERNOUS NERVE INJURY (2006) (2)
Feasibility Study on Intravitreal and Subretinal Delivery of Adult Stem/Progenitor Cells (MSCs) for Retinal Repair (2010) (2)
Circular dichroism analysis of novel recombinant type II procollagens (1996) (2)
Minigene and gene knock-out experiments of the COL11A2 gene in transgenic mice (1994) (1)
Meeting Report: Mesenchymal and nonhematopoietic stem cells: recent progress and current controversies (2001) (1)
514. Potential of Bone Marrow Mesenchymal Stem Cells for Cystic Fibrosis Therapy (2004) (1)
Intracellular Hydroxylation of Non-Helical Protocollagen to Form Triple-Helical and Subsequent Secretion of the Molecule Procollagen (1974) (1)
A subtle disease and a dilemma: can cells secrete collagen that does not contain a sugar-tag? (1972) (1)
Embryonic Stem Cells Versus Adults Stem Cells: Some Seemingly Simple Questions (2004) (1)
Mass spectrometric gene diagnosis of one base substitution from PCR amplified human collagen gene of an OI patient (1996) (1)
Expression of a partially deleted gene of human type II procollagen ( COL 2 AJ ) in transgenic mice produces a chondrodysplasia ( type II collagen / deletion mutations / collagen depletion ) (1)
Hydroxylation of prolyl residues in type II procollagen in vitro and in cellulo. Lack of preferential hydroxylation of specific regions of the protein. (1982) (1)
Regulation of alternative splicing of a partially deleted gene of human type II procollagen in transgenic mice (1994) (1)
Collagen II Containing a Cys Substitution for Arg-α1-519 (1997) (1)
Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells. Commentary (2006) (1)
Single basemutation inthetypeIIprocollagen gene(COL2AI) asa causeofprimary osteoarthritis associated witha mildchondrodysplasia (1990) (1)
BEFORE BEING INCORPORATED INTO CROSSLINKED ELASTIN FIBERS (1977) (1)
Preservation of Visual Function After Intraocular Transplantation of BDNF Secreting Mesenchymal Stem Cells in Glaucomatous Rat Eyes (2007) (1)
Streptozotocin-diabetes but not galactose-feeding increases the serum concentration of type IV collagen antigens in rats. (1990) (1)
Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome (2014) (1)
Inhibition of marrow osteoprogenitor cell differentiation by murine osteo-blasts (1996) (0)
Effect of Cis-4-Hydroxy-L-ProI me on Lung Mechanics and Collagen Content of Bleomycin-Treated (2015) (0)
Regulating in Vitro Motility of Human Mesenchymal Stem Cells with Macrophage Migration Inhibitory Factor (MIF) and a Small-Molecule MIF Antagonist (2012) (0)
A rapid and simple PCR-based protocol for isolation or large cDNAs from differetially expressed genes (1994) (0)
Recombinant C-proteinase and processes, methods and uses thereof (1997) (0)
Stromal cells isolated and methods of use and the same. (1996) (0)
Genetic Linkage Analysis of Hereditary Arthro-Ophthalmopathy (Stickler Syndrome) and the Type 11 Procollagen Gene (2006) (0)
Lysozymuria as an Indication of Renal Tubular Damage. (1964) (0)
Isolated stromal cells and methods of use thereof (1996) (0)
Type i pre pro collagen chains synthesized in a messenger rna dependent reticulocyte lysate (1979) (0)
Dentimogenesis imperfecta induced in mice by expression of COL1A1 chain with a partial deletion (1994) (0)
Replacement of bone cells expressing a muated COL1A1 gene in a transgenic mouse for osteogenesis imperfecta (1997) (0)
Osteosarcoma Derived from Cultured Mesenchymal Stem Cells. (2006) (0)
Title: Phenotype, Donor Age and Gender Affect Function of Human Bone Marrow-derived Mesenchymal Stromal Cells (0)
Separation of human pro alpha 1 (I) and pro alpha 2 (I) procollagen chains by reverse phase high performance liquid chromatography. (1982) (0)
ErratumStem Cells in the Face: Tooth Regeneration and Beyond (2012) (0)
Mapping of the collagen sites of interaction involved at the early stages of collagen fibril assembly (1997) (0)
A 1.9‐Kb 5' Fragment from the Human COL1A1 Gene Drives Inappropriate Expression of the Human COL2A1 Gene in Tissues of Trangenic Mice that Normally Express Only the COL1A1 Gene (1996) (0)
Exosomes and uses thereof in diseases of the brain (2017) (0)
O11. A transgenic mouse model for osteogenesis imperfecta: electron microscopic and analytical comparison with human bone (1994) (0)
Faculty Opinions recommendation of Muse cells and induced pluripotent stem cell: implication of the elite model. (2012) (0)
Mesenchymal Cancer Cells Can Arise from Ex Vivo Modified Mesenchymal Stem Cells. (2005) (0)
Defining a Therapeutic Window for Sterile Injuries of Cornea. The Anti-inflammatory Protein (TSG-6) Inhibits the Severe Second Phase of Inflammation (2011) (0)
The effect of intravitreous administration of recombinant TSG‐6 protein on the retinal lesion in Ccl2−/−/Cx3cr1−/− mice (2011) (0)
Intravitreal Administration Of Adult Stem/progenitor Cells And Their Secreted Proteins Delays Retinal Degeneration By Decreasing Apoptosis In Two Rat Models (2011) (0)
Intraperitoneally infused human mesenchymal stem cells form aggregates with mouse immune cells and attach to peritoneal organs (2016) (0)
ヒトI型プロコラーゲンのプレプロα1(I)鎖に対する完全長cDNAクローンの構造 (1988) (0)
Letter Darwin J. Prockop (1996) (0)
Differentiation of human bone marrow mesenchymal stem cells into airway epithelia (2003) (0)
ENZ YMA TIC H YDROX YLA TION OF PROLINE AND LYSINE IN PROTOCOLLAGEN* (0)
MSCs: Changing Hypotheses, Paradigms, and Controversies on Mechanisms of Action in Repairing Tissues (2013) (0)
Assessment of small polymorphisms in defined human collagen gene segments (1986) (0)
Intravenous MSCs embolize to lung and improve myocardial infarcts in mice by activation to express the anti‐inflammatory protein TSG‐6 (2009) (0)
Sequences required for tissue-specific expression as mRNA and protein of a mini-COL1A1 gene in transgenic mice (1994) (0)
Potential Use of Marrow Stromal Cells for Therapy of Osteogenesis Imperfecta and Osteoporosis (1997) (0)
Substitution of cysteine for glycine 904 of the alpha 1 i chain in a lethal variant of osteogenesis imperfecta the asymptomatic mother is a carrier of a different mutation in type i procollagen (1988) (0)
Creation of a System for the Assembly and Expression of DNA Constructs Encoding Novel Recombinant Human Procollagen II (1996) (0)
Abstracts from the Second International Conference on Molecular Biology and Pathology of Matrix. Philadelphia, Pennsylvania, June 15-18, 1988. (1988) (0)
An A−2→G transition at the 3′ acceptor splice site of IVS17 characterizes the COL2A1 gene mutation in the original stickler kindred (1994) (0)
East Coast Connective Tissue Club Meeting (1981) (0)
PS2-28 MSCs and TSG-6 abort the inflammatory cascade of zymosan-induced peritonitis by binding to CD44 on resident macrophages to inhibit NFκB signaling (2010) (0)
Intranasal Administration of MSC‐Derived Exosomes Modulate Status Epilepticus Induced Abnormal Plasticity of Newly Born Neurons and Microglial Activation in the Hippocampus (2019) (0)
The incidence of mutations in the COL2A1 gene in patients with cartilage disorders (1994) (0)
Properties and Therapeutic Potentials of Adult Stem Cells from Bone Marrow Stroma (MSCs) (2019) (0)
Faculty Opinions recommendation of Nuclear reprogramming to a pluripotent state by three approaches. (2011) (0)
Implants comprising immunologically isolated stromal cells and their use. (1996) (0)
Review of the national arthritis advisory board symposium, “molecular biology: its potential for advancing rheumatology research” (1987) (0)
FIRST DEMONSTRATION OF A STRUCTURAL MUTATION OF PROCOLLAGEN IN A PATIENT WITH EHLERS-DANLOS SYNDROME (EDS): 69 (1980) (0)
High‐Capacity Assay to Evaluate Colony‐Forming Efficiency and Multipotency of Bone Marrow Stromal Cells (2009) (0)
A cDNA cassette system for the synthesis of recombinant procollagen I: A pilot study for artificial temporomandibular joint materials (1999) (0)
144. Genetic study of a murine model for opioid addiction (1996) (0)
cells from bone marrow stroma (2016) (0)
Integrated microfluidic system for the processing of membrane proteins isolated from stem cells (2006) (0)
Two cysteine substitutions in procollagen 1: a glycine replacement near the N-terminus of xl(lI chain causes lethal osteogenesis imperfecta and a glycine replacement in the x2(1) chain markedly destabilizes the triple helix (2005) (0)
MSCs roll into the mainstream (2006) (0)
Transmission electron microscopy analysis of recombinant human type II collagen fibrils (1994) (0)
Abstract 201: The combination treatment of TNF-α and poly (dA:dT) preactivated hMSCs with doxorubicin enhances antitumorigenic activity (2014) (0)
Can proline analogues be used to prevent fibroblasts from overgrowing cultures of epithelial cells? (1980) (0)
Prospects for therapies with adult stem/progenitor cells (MSCs) or the proteins they produce (2013) (0)
Intravenously Infused Mesenchymal Stem/progenitor Cells (MSCs) Promote The Long-term Survival Of Corneal Allografts By Secreting TNF-α Stimulated Gene/protein 6 To Reduce The Early Surgery-induced Inflammation (2012) (0)
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. (2007) (0)
Collagen II containing a cys substitution for arg α1–519. Functional assays of the protein are consistent with a mild disease phenotype (1996) (0)
Soluble Factors From Adult Stem/Progenitor Cells (MSCs) Protect Corneal Epithelial Progenitors by Promoting Proliferation and Preventing Apoptosis (2010) (0)
Specific and selective inhibition of translation of mRNA for type II procollagen in cells of transgenic mice that synthesize type I procollagen. A possible role for endogneous antisense RNA (1996) (0)
Triple-Helix Formation and Disulphide Bonding during the Biosynthesis of Lens Basement-Membrane Collagen (1974) (0)
Identification of novel genes differentially expressed in humano steoblasts during mineralization In Vitro (1994) (0)
Potential Therapies with Adult Stem/Progenitor Cells from Bone Marrow (MSCs) and the Proteins They Produce in Response to Injuries from Injured Tissues (2012) (0)
Polymerase chain reaction-denaturing gradient gel electrophoresis screening for mutations in the COL1A1 gene in osteogenesis imperfecta (1994) (0)
The Gordon Wilson lecture. Mutations in type I procollagen genes. An explanation for brittle bones and a paradigm for other diseases of connective tissue. (1989) (0)
Linkage of chondrocalcinosis to chromosome 5p15.1-.2 in a large Argentinean pedigree. (1997) (0)
Elements downstream of the ATTAAA signal within human type II procollagen gene are required for correct transcription termination and the use of the poly(A) site (1994) (0)
Inhibition of scar formation by the proline analog cis-hydroxyproline. (1973) (0)
The synthesis of type I collagen fibers and potential inhibitors of the process. (1984) (0)
The Reparative Power of Multipotent Stromal Cells from Bone Marrow (2006) (0)
Type I collagen transgene used as a marker to trace donor marrow stromal cells. Tranpslanted cells persist up to five months in bone marrow, spleen, cartilage and lung (1994) (0)
Role of the first intron in the regulation of the COL 1A1 gene. (1996) (0)
Abstract 302: The Importance of Adhesion in Multipotent Stromal Cell-Induced Coronary Collateral Growth/Arteriogenesis (2007) (0)

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