Justin Yerbury
#149,504
Most Influential Person Now
Australian molecular biologist
Justin Yerbury's Degrees
- Bachelors Biotechnology University of Wollongong
- PhD Molecular Biology University of Wollongong
Why Is Justin Yerbury Influential?
(Suggest an Edit or Addition)According to Wikipedia, Justin John Yerbury was an Australian molecular biologist who was spurred to follow a career in biological research when he discovered his family has the genetic form of motor neurone disease . He held the position of Professor in Neurodegenerative Disease at the University of Wollongong. He was diagnosed with MND himself in 2016, but continued to research until his death from the disease in 2023.
Justin Yerbury's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms (2014) (356)
- ANS binding reveals common features of cytotoxic amyloid species. (2010) (326)
- The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures (2007) (303)
- Walking the tightrope: proteostasis and neurodegenerative disease (2016) (163)
- CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia (2016) (160)
- Extracellular chaperones and proteostasis. (2013) (145)
- Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity. (2008) (142)
- Quality control of protein folding in extracellular space (2005) (125)
- Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions (2015) (117)
- The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin. (2005) (108)
- α2-Macroglobulin and Haptoglobin Suppress Amyloid Formation by Interacting with Prefibrillar Protein Species* (2009) (96)
- The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins (2020) (96)
- Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis: A Study of Humans and a Transgenic Mouse Model (2018) (95)
- Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity. (2008) (95)
- Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype (2013) (90)
- Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS (2017) (86)
- Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis (2019) (86)
- The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species. (2007) (84)
- The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro (2013) (83)
- P2X7 Receptor Activation Induces Reactive Oxygen Species Formation and Cell Death in Murine EOC13 Microglia (2013) (81)
- Structural Characterization of Clusterin-Chaperone Client Protein Complexes* (2009) (78)
- Clusterin facilitates in vivo clearance of extracellular misfolded proteins (2011) (77)
- Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein folding. (2009) (74)
- Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways (2016) (73)
- SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation (2015) (70)
- Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity (2016) (69)
- Extracellular wildtype and mutant SOD1 induces ER–Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells (2013) (65)
- Clusterin interacts with Paclitaxel and confer Paclitaxel resistance in ovarian cancer. (2008) (63)
- Extracellular chaperones modulate the effects of Alzheimer’s patient cerebrospinal fluid on Aβ1-42 toxicity and uptake (2009) (57)
- The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation (2018) (56)
- Roles of extracellular chaperones in amyloidosis. (2012) (55)
- The heat shock response in neurons and astroglia and its role in neurodegenerative diseases (2017) (55)
- Clusterin facilitates in vivo clearance of extracellular misfolded proteins. (2011) (54)
- Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons (2018) (53)
- Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis (2013) (47)
- Clusterin protects neurons against intracellular proteotoxicity (2017) (46)
- Misfolded Polyglutamine, Polyalanine, and Superoxide Dismutase 1 Aggregate via Distinct Pathways in the Cell* (2014) (45)
- The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases (2015) (43)
- Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms (2013) (41)
- Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles (2017) (41)
- Proteome Homeostasis Dysfunction: A Unifying Principle in ALS Pathogenesis (2020) (38)
- SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS (2017) (37)
- P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice (2017) (37)
- Rapid flow cytometric measurement of protein inclusions and nuclear trafficking (2016) (35)
- SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation (2015) (35)
- Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy (2019) (34)
- Evaluation of Skin Fibroblasts from Amyotrophic Lateral Sclerosis Patients for the Rapid Study of Pathological Features (2015) (28)
- Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells (2018) (26)
- The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation (2019) (26)
- Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis (2019) (25)
- The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS (2019) (22)
- Flow cytometric measurement of the cellular propagation of TDP-43 aggregation (2017) (21)
- Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex (2017) (21)
- Therapeutic targets in extracellular protein deposition diseases. (2009) (20)
- CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper-Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding. (2018) (20)
- Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS (2020) (18)
- The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis (2017) (17)
- Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises (2020) (17)
- Protein aggregates stimulate macropinocytosis facilitating their propagation (2016) (16)
- The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice (2020) (16)
- Non-Viral Vector-Mediated Gene Therapy for ALS: Challenges and Future Perspectives. (2021) (16)
- Extracellular Chaperones. (2010) (15)
- Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection (2020) (15)
- P2X7 receptor antagonism in amyotrophic lateral sclerosis (2017) (15)
- Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation (2017) (14)
- Disabled in academia: to be or not to be, that is the question (2021) (14)
- P 2 X 7 receptor activation induces reactive oxygen species formation and cell death in murine EOC 13 microglia (2017) (14)
- Extracellular Chaperones and Amyloids (2008) (12)
- p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death (2021) (12)
- The small heat shock proteins B-crystallin and Hsp 27 suppress SOD 1 aggregation in vitro (2016) (12)
- The pivotal role of Ubiquitin-activating enzyme E1 (UBA1) in neuronal health and neurodegeneration. (2020) (11)
- Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1G93A) mouse model of amyotrophic lateral sclerosis include sex‐dependent phenotypes (2020) (11)
- The prion-like nature of amyotrophic lateral sclerosis. (2020) (11)
- Protein Chemistry of Amyloid Fibrils and Chaperones: Implications for Amyloid Formation and Disease (2010) (10)
- Longitudinal assessment of metal concentrations and copper isotope ratios in the G93A SOD1 mouse model of amyotrophic lateral sclerosis. (2017) (10)
- Unbiased Label-Free Quantitative Proteomics of Cells Expressing Amyotrophic Lateral Sclerosis (ALS) Mutations in CCNF Reveals Activation of the Apoptosis Pathway: A Workflow to Screen Pathogenic Gene Mutations (2021) (10)
- Extracellular chaperones. (2013) (10)
- Strategies to promote the maturation of ALS-associated SOD1 mutants: small molecules return to the fold (2019) (9)
- Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells (2020) (7)
- The trajectory taken by dimeric Cu/Zn superoxide dismutase through the protein unfolding and dissociation landscape is modulated by salt-bridge formation. (2019) (7)
- Dysregulation of microRNA biogenesis machinery and microRNA/RNA ratio in skeletal muscle of amyotrophic lateral sclerosis mice (2017) (6)
- Network Approaches to the Understanding of Alzheimer's Disease: From Model Organisms to Humans. (2016) (6)
- TDP-43 is a ubiquitylation substrate of the SCFcyclin F complex (2022) (5)
- Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy (2017) (4)
- Assessment of metal concentrations in the SOD1G93A mouse model of amyotrophic lateral sclerosis and its potential role in muscular denervation, with particular focus on muscle tissue (2018) (4)
- The interplay of protein aggregates, microglia and neuroinflammation in neurodegenerative disease (2015) (4)
- Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal-like cells (2020) (3)
- CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1G93A mice with a C57BL/6 background (2021) (3)
- Vulnerability of the spinal motor neuron presynaptic terminal sub-proteome in ALS (2022) (3)
- Mutant Cu/Zn Superoxide Dismutase (A4V) Turnover Is Altered in Cells Containing Inclusions (2021) (3)
- Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis (2019) (3)
- A copper chaperone–mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis (2022) (3)
- Ubiquitin homeostasis disruption, a common cause of proteostasis collapse in amyotrophic lateral sclerosis? (2022) (3)
- Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells. (2020) (2)
- Instant insight: think outside the cell (2008) (1)
- Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation (2017) (1)
- Progress in biophysics and molecular biology proteostasis impairment and ALS. (2022) (1)
- Protein Aggregation in Amyotrophic Lateral Sclerosis (2021) (1)
- Selenium-based compounds: Emerging players in the ever-unfolding story of SOD1 in amyotrophic lateral sclerosis. (2020) (1)
- P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons (2022) (1)
- Extracellular wildtype and mutant SOD1 induces ER–Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells (2013) (1)
- The heat shock response in neurons and astroglia and its role in neurodegenerative diseases (2017) (1)
- The N-terminus of amyloid-beta plays a crucial role in its aggregation and toxicity (2010) (1)
- SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation (2015) (1)
- High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS) (2021) (0)
- Evaluation of Skin Fibroblasts from Amyotrophic Lateral Sclerosis Patients for the Rapid Study of Pathological Features (2015) (0)
- Clusterin protects neurons against intracellular proteotoxicity (2017) (0)
- Cells Overexpressing ALS-Associated SOD1 Variants Are Differentially Susceptible to CuATSM-Associated Toxicity. (2022) (0)
- The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro (2012) (0)
- Misfolding at the synapse: A role in amyotrophic lateral sclerosis pathogenesis? (2022) (0)
- Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways (2016) (0)
- Some diseases, like mine, deteriorate rapidly - disability services need to keep up (2018) (0)
- Characterisation of novel extracellular molecular chaperones and their effects on amyloid formation (2007) (0)
- ALS-associated mutants of SOD1, TDP-43, FUS, C9ORF72 and UBQLN2 disrupt proteostasis in neuronal cell culture (2014) (0)
- THEME 9 IN VITRO EXPERIMENTAL MODELS (2014) (0)
- Expansion of suppressor tregs by IL-2/IL-2 MAB complexes slows disease progression in the mutant SOD1 mouse model of ALS (2015) (0)
- Identification Of A novel FTD-MND gene on chromosome 16 (2016) (0)
- Assessment of metal concentrations in the SOD 1 G 93 A mouse model of 1 amyotrophic lateral sclerosis and its potential role in muscular denervation , with 2 particular focus on muscle tissue 3 4 (2018) (0)
- Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells (2018) (0)
- Motor neuron disease proteins activate complement and generate C5a (2017) (0)
- Distinct Pathways in the Cell Superoxide Dismutase 1 Aggregate via Misfolded Polyglutamine , Polyalanine , and Molecular Bases of Disease : (2014) (0)
- Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis (2019) (0)
- Behavioural effects of cage systems on the G93A Superoxide Dismutase 1 transgenic mouse model for amyotrophic lateral sclerosis (2021) (0)
- Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis (2020) (0)
- Assessment of protein inclusions in cultured cells using automated image analysis (2022) (0)
- Supplementary material from "Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF (cyclin F) complex" (2017) (0)
- Prion and Prion-like Diseases in Humans (2013) (0)
- The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation (2018) (0)
- The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Di ff erentiation (2019) (0)
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What Schools Are Affiliated With Justin Yerbury?
Justin Yerbury is affiliated with the following schools:
