J. Keith Joung
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American pathologist and molecular biologist
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J. Keith Joungbiology Degrees
Biology
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Pathology
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#170
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Molecular Biology
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Biology
J. Keith Joung's Degrees
- Doctorate Medicine Harvard University
Why Is J. Keith Joung Influential?
(Suggest an Edit or Addition)According to Wikipedia, J. Keith Joung is an American pathologist and molecular biologist who holds the Robert B. Colvin Endowed Chair in Pathology at Massachusetts General Hospital and is Professor of Pathology at Harvard Medical School. He is a leading figure in the field of genome editing and has pioneered the development of designer nucleases and sensitive off-target detection methods.
J. Keith Joung's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- High frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells (2013) (2826)
- CRISPR-Cas systems for editing, regulating and targeting genomes (2014) (2776)
- Efficient genome editing in zebrafish using a CRISPR-Cas system (2013) (2509)
- Improving CRISPR-Cas nuclease specificity using truncated guide RNAs (2014) (1732)
- GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases (2014) (1612)
- High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets (2015) (1393)
- TALENs: a widely applicable technology for targeted genome editing (2012) (1323)
- Engineered CRISPR-Cas9 nucleases with altered PAM specificities (2015) (1182)
- CRISPR RNA-guided activation of endogenous human genes (2013) (1023)
- 731. High-Fidelity CRISPR-Cas9 Nucleases with No Detectable Genome-Wide Off-Target Effects (2016) (957)
- Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing (2014) (909)
- Enhanced proofreading governs CRISPR-Cas9 targeting accuracy (2017) (780)
- Gene therapy comes of age (2018) (769)
- Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo (2014) (754)
- Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. (2008) (726)
- High frequency modification of plant genes using engineered zinc finger nucleases (2009) (685)
- FLAsH assembly of TALeNs for high-throughput genome editing (647)
- Targeted gene disruption in somatic zebrafish cells using engineered TALENs (2011) (642)
- FLASH Assembly of TALENs Enables High-Throughput Genome Editing (2012) (576)
- CRISPResso2 provides accurate and rapid genome editing sequence analysis (2019) (559)
- Selection-Free Zinc-Finger Nuclease Engineering by Context-Dependent Assembly (CoDA) (2010) (535)
- Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. (2009) (534)
- CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets (2017) (508)
- Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells (2016) (508)
- Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition (2015) (492)
- Toddler: An Embryonic Signal That Promotes Cell Movement via Apelin Receptors (2014) (467)
- Revealing Off-Target Cleavage Specificities of Zinc Finger Nucleases by In Vitro Selection (2011) (452)
- Unexpected failure rates for modular assembly of engineered zinc fingers (2008) (431)
- Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins (2013) (398)
- Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. (2014) (384)
- Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System (2013) (383)
- A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions. (2000) (379)
- Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells (2015) (378)
- Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo (2014) (370)
- Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases (2016) (366)
- ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool (2010) (363)
- Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions (2013) (357)
- High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases (2010) (356)
- Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors (2019) (354)
- Efficient In Vivo Genome Editing Using RNA-Guided Nucleases (2013) (343)
- In Situ Genetic Correction of the Sickle Cell Anemia Mutation in Human Induced Pluripotent Stem Cells Using Engineered Zinc Finger Nucleases (2011) (331)
- Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing (2018) (319)
- A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions (2012) (313)
- Zinc-finger nucleases: the next generation emerges. (2008) (313)
- Interactome Maps of Mouse Gene Regulatory Domains Reveal Basic Principles of Transcriptional Regulation (2013) (302)
- An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities (2018) (279)
- Activation of prokaryotic transcription through arbitrary protein–protein contacts (1997) (279)
- Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool (2007) (266)
- TALEN-based gene correction for epidermolysis bullosa. (2013) (266)
- Rapid Mutation of Endogenous Zebrafish Genes Using Zinc Finger Nucleases Made by Oligomerized Pool ENgineering (OPEN) (2009) (266)
- Targeted Mutagenesis of Duplicated Genes in Soybean with Zinc-Finger Nucleases1[W][OA] (2011) (263)
- Enhanced proofreading governs CRISPR-Cas9 targeting accuracy Please share how this access benefits you. Your story matters (2018) (247)
- Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs (2012) (244)
- In vivo CRISPR editing with no detectable genome-wide off-target mutations (2018) (243)
- Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly (2006) (217)
- Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays (2009) (212)
- CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells (2020) (200)
- Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity (2014) (200)
- Robust, synergistic regulation of human gene expression using TALE activators (2013) (195)
- Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs (2017) (189)
- High levels of AAV vector integration into CRISPR-induced DNA breaks (2019) (183)
- CRISPR DNA base editors with reduced RNA off-target and self-editing activities (2019) (181)
- Discovery of widespread type I and type V CRISPR-Cas inhibitors (2018) (180)
- Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects (2012) (180)
- piggyBac transposase tools for genome engineering (2013) (178)
- Improved Somatic Mutagenesis in Zebrafish Using Transcription Activator-Like Effector Nucleases (TALENs) (2012) (173)
- Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection (2003) (162)
- DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases. (2008) (156)
- Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors (2017) (149)
- Activities and specificities of CRISPR/Cas9 and Cas12a nucleases for targeted mutagenesis in maize (2018) (149)
- Targeted mutagenesis in zebrafish using customized zinc-finger nucleases (2009) (143)
- Therapeutic base editing of human hematopoietic stem cells (2019) (133)
- Comparison of zinc finger nucleases for use in gene targeting in mammalian cells. (2008) (129)
- A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing (2020) (128)
- Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. (2016) (121)
- Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss (2019) (119)
- Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion (2010) (116)
- Repression of phase-variable cup gene expression by H-NS-like proteins in Pseudomonas aeruginosa. (2005) (115)
- Fanconi anemia gene editing by the CRISPR/Cas9 system. (2015) (102)
- CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease (2018) (96)
- Chromatin regulation at the frontier of synthetic biology (2015) (96)
- High-throughput β-galactosidase assay for bacterial cell-based reporter systems (2004) (95)
- Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing. (2015) (91)
- Continuous directed evolution of DNA-binding proteins to improve TALEN specificity (2015) (90)
- Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc fingers and engineered zinc-finger arrays (2008) (88)
- Synergistic activation of transcription by bacteriophage lambda cI protein and E. coli cAMP receptor protein. (1994) (88)
- Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage (2014) (84)
- DNA-binding Specificity Is a Major Determinant of the Activity and Toxicity of Zinc-finger Nucleases. (2008) (84)
- Allele-Specific CRISPR-Cas9 Genome Editing of the Single-Base P23H Mutation for Rhodopsin-Associated Dominant Retinitis Pigmentosa. (2018) (84)
- CAUSEL: An epigenome and genome editing pipeline for establishing function of non-coding GWAS variants (2015) (83)
- Engineering Designer Transcription Activator‐‐Like Effector Nucleases (TALENs) by REAL or REAL‐Fast Assembly (2012) (79)
- Zinc-finger nucleases for somatic gene therapy: the next frontier. (2011) (77)
- Genome editing technologies: defining a path to clinic. (2015) (77)
- Targeted DNA Demethylation and Endogenous Gene Activation Using Programmable TALE-TET1 Fusions (2013) (75)
- Targeted Deletion and Inversion of Tandemly Arrayed Genes in Arabidopsis thaliana Using Zinc Finger Nucleases (2013) (75)
- Optimization of AsCas12a for combinatorial genetic screens in human cells (2019) (72)
- CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells (2021) (71)
- PrimeDesign software for rapid and simplified design of prime editing guide RNAs (2020) (70)
- An improved predictive recognition model for Cys2-His2 zinc finger proteins (2014) (70)
- Hypoxia drives transient site-specific copy gain and drug-resistant gene expression (2015) (68)
- Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells (2018) (67)
- Synergistic activation of transcription by Escherichia coli cAMP receptor protein. (1993) (65)
- Defining CRISPR–Cas9 genome-wide nuclease activities with CIRCLE-seq (2018) (61)
- High-throughput beta-galactosidase assay for bacterial cell-based reporter systems. (2004) (60)
- In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites (2013) (57)
- Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair. (2014) (56)
- A Zebrafish Model of Myelodysplastic Syndrome Produced through tet2 Genomic Editing (2014) (53)
- Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function. (2014) (52)
- An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins (2008) (51)
- Targeted genome editing in human cells using CRISPR/Cas nucleases and truncated guide RNAs. (2014) (51)
- ZFNGenome: A comprehensive resource for locating zinc finger nuclease target sites in model organisms (2011) (50)
- Open-source guideseq software for analysis of GUIDE-seq data (2016) (46)
- Nodal patterning without Lefty inhibitory feedback is functional but fragile (2017) (46)
- Zinc-finger Nucleases: The Next Generation Emerges. (2008) (45)
- CRISPR-Cas systems for genome editing, regulation and targeting (2015) (45)
- Corrigendum: CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets (2018) (40)
- Targeted disruption of DNMT 1 , DNMT 3 A and DNMT 3 B in human embryonic stem cells (2015) (40)
- Engineering zinc finger nucleases for targeted mutagenesis of zebrafish. (2011) (38)
- Engineering customized TALE nucleases (TALENs) and TALE transcription factors by fast ligation-based automatable solid-phase high-throughput (FLASH) assembly. (2013) (38)
- Context influences on TALE–DNA binding revealed by quantitative profiling (2015) (34)
- Evaluation of OPEN Zinc Finger Nucleases for Direct Gene Targeting of the ROSA26 Locus in Mouse Embryos (2012) (33)
- Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences (2010) (30)
- Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based method (2007) (29)
- DNA Binding Made Easy (2009) (28)
- Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands. (2004) (27)
- CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data (2018) (26)
- Counter-selectable marker for bacterial-based interaction trap systems. (2006) (26)
- Reply to “Genome editing with modularly assembled zinc-finger nucleases” (2010) (25)
- What's changed with genome editing? (2014) (24)
- A Combined Yeast/Bacteria Two-hybrid System (2005) (24)
- Genetic strategy for analyzing specificity of dimer formation: Escherichia coli cyclic AMP receptor protein mutant altered in its dimerization specificity. (1995) (24)
- Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito (2021) (23)
- Synthetic protein–protein interaction domains created by shuffling Cys2His2 zinc-fingers (2006) (22)
- Genome Editing Technologies: Defining a Path to Clinic: Genomic Editing: Establishing Preclinical Toxicology Standards, Bethesda, Maryland 10 June 2014. (2015) (22)
- Targeted Mutagenesis in Zebrafish Using CRISPR RNA-Guided Nucleases. (2015) (21)
- Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway. (2017) (21)
- Genome Editing in Human Cells Using CRISPR/Cas Nucleases (2015) (20)
- “Unexpected mutations after CRISPR-Cas9 editing in vivo” are most likely pre-existing sequence variants and not nuclease-induced mutations (2017) (20)
- IκB Kinase β (IKBKB) Mutations in Lymphomas That Constitutively Activate Canonical Nuclear Factor κB (NFκB) Signaling* (2014) (20)
- Engineering Designer Nucleases with Customized Cleavage Specificities (2011) (19)
- A Code of Ethics for Gene Drive Research (2021) (19)
- Clinically-driven design of synthetic gene regulatory programs in human cells (2021) (18)
- Unwanted mutations: Standards needed for gene-editing errors (2015) (17)
- Technologies and Computational Analysis Strategies for CRISPR Applications. (2020) (16)
- Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway (2017) (16)
- Temporal and Spatial Post-Transcriptional Regulation of Zebrafish tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly (2018) (15)
- Identifying and modifying protein–DNA and protein–protein interactions using a bacterial two‐hybrid selection system (2001) (15)
- Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo” (2018) (14)
- Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model (2015) (14)
- Engineering single Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system. (2010) (14)
- CRISPR adenine and cytosine base editors with reduced RNA off-target activities (2019) (14)
- Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish (2019) (14)
- Induction of Stable Drug Resistance in Human Breast Cancer Cells Using a Combinatorial Zinc Finger Transcription Factor Library (2011) (13)
- Synergistic Activation of Transcription in E. coli (1997) (13)
- Translating the Genomics Revolution: The Need for an International Gene Therapy Consortium for Monogenic Diseases (2013) (12)
- Scalable characterization of the PAM requirements of CRISPR–Cas enzymes using HT-PAMDA (2021) (12)
- Genome Editing: A Tool For Research and Therapy: Towards a functional understanding of variants for molecular diagnostics using genome editing (2014) (12)
- Augmenting and directing long-range CRISPR-mediated activation in human cells (2021) (12)
- Multidimensional control of therapeutic human cell function with synthetic gene circuits (2022) (11)
- Engineered Zinc Finger Nucleases for Targeted Genome Editing (2013) (11)
- Defining genome-wide CRISPR–Cas genome-editing nuclease activity with GUIDE-seq (2021) (10)
- High-precision CRISPR-Cas9 base editors with minimized bystander and off-target mutations (2018) (10)
- Engineering Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system. (2007) (10)
- 1 1 2 Enhanced proofreading governs CRISPR-Cas 9 targeting accuracy 3 4 (2017) (9)
- In vivo CRISPR-Cas gene editing with no detectable genome-wide off-target mutations (2018) (8)
- Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish (2019) (8)
- Zebrafish dscaml1 Deficiency Impairs Retinal Patterning and Oculomotor Function (2020) (8)
- Global-scale CRISPR gene editor specificity profiling by ONE-seq identifies population-specific, variant off-target effects (2021) (8)
- Erratum: Unexpected failure rates for modular assembly of engineered zinc fingers (2008) (8)
- Erratum: Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1 (Cell Stem Cell (2014) 14 (781795)) (2014) (7)
- Engineered CRISPR prime editors with compact, untethered reverse transcriptases (2022) (7)
- Accelerating research through reagent repositories: the genome editing example (2015) (7)
- Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources (2020) (7)
- The bacterial two-hybrid system as a reporter system for analyzing protein-protein interactions. (2007) (6)
- Analysis and comparison of genome editing using CRISPResso2 (2018) (6)
- Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function (2020) (6)
- CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer’s disease PSEN1 M146L mutation (2022) (5)
- Impact of Genetic Variation on CRISPR-Cas Targeting. (2018) (5)
- 58. Engineered Cas9 Variants with Novel PAM Specificities Expand the Targeting Range of CRISPR/Cas Nucleases (2015) (5)
- Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors (2022) (4)
- Allele-specific editing of rhodopsin P23H knock-in mice broadens therapeutic potential of CRISPR/Cas for dominant genetic diseases (2017) (3)
- Engineered Cys 2 His 2 zinc finger DNA-binding domains (2004) (3)
- Genome-wide specificity profiles of CRISPR-Cas Cpf1 nucleases in human cells (2016) (3)
- Publisher Correction: Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing (2020) (3)
- Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors (2019) (2)
- Identification of promoter targets of enhancers by epigenetic knockdown using TAL DNA binding proteins (2013) (2)
- Zebrafish Dscaml1 is Essential for Retinal Patterning and Function of Oculomotor Subcircuits (2019) (2)
- Joung et al. reply (2010) (2)
- Factor X Mutant Zebrafish Tolerate a Severe Hemostatic Defect in Early Development Yet Develop Lethal Hemorrhage in Adulthood (2015) (1)
- Inducible, tunable and multiplex human gene regulation using CRISPR-Cpf1-based transcription factors (2017) (1)
- Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs (2018) (1)
- Identification of promoter targets of enhancers by epigenetic knockdown using TAL DNA binding proteins (2013) (1)
- Circularization for In vitro Reporting of Cleavage Effects (CIRCLE-seq) (2017) (1)
- Building with biological LEGO. Interview by Kristie Nybo. (2012) (1)
- Errata to "DNA-binding Specificity Is a Major Determinant of the Activity and Toxicity of Zinc-finger Nucleases". (2008) (1)
- Broadening Staphylococcus aureus Cas 9 Targeting Range by Modifying PAM Recognition (2015) (1)
- An improved strategy for constructing "designer" Cys2His2 zinc finger proteins. (2003) (1)
- FHIT gene and cancer. (1996) (1)
- THROMBOSIS AND HEMOSTASIS Targeted mutagenesis of zebra fi sh antithrombin III triggers disseminated intravascular coagulation and thrombosis , revealing insight into function (2014) (1)
- Allele-specific gene disruption through discrimination of a single base change by S. aureus Cas9-KKH prevents progressive hearing loss after AAV-mediated gene delivery (2019) (1)
- Author Correction: CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells (2021) (1)
- Altering, Improving, And Defining The Specificities Of Crispr-Cas Nucleases (2017) (0)
- Limiting antigen escape in multiple myeloma by dual antigen-targeting of BCMA and TACI using the natural ligand APRIL (2017) (0)
- In vivo allele-specific CRISPR/Cas9 gene editing in the rhodopsin P23H knockin mouse model (2017) (0)
- Arn guides multiplex (2014) (0)
- Abstract 476: Loss of chd5-mediated tumor suppression accelerates MYCN-driven neuroblastoma tumorigenesis in zebrafish (2015) (0)
- 246. Optical Control of Mammalian Endogenous Transcription and Epigenetic States (2016) (0)
- Genetic strategy for analyzin specificity (2007) (0)
- Genetic strategy for analyzin specificity of dimer formation: Escheric a ia coli vclic AMP receptor .s dimeriz protein mutant ation specificity (2011) (0)
- Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing (2019) (0)
- Abstract IA07: Defining, Optimizing, and Altering the Specificities of CRISPR-Cas Nucleases (2017) (0)
- Abstract 2433: Loss of chd5-mediated gene repression synergizes with MYCN to accelerate neuroblastoma tumorigenesis in zebrafish (2016) (0)
- A zebrafish model of myelodysplasia produced through tet2 genomic editing (2015) (0)
- Epigenetically regulated site-specific nucleases (2017) (0)
- CRISPResso2 provides accurate and rapid genome editing sequence analysis (2019) (0)
- In vivo CRISPR editing with no detectable genome-wide off-target mutations (2018) (0)
- Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State (2023) (0)
- Defining CRISPR–Cas9 genome-wide nuclease activities with CIRCLE-seq (2018) (0)
- Accelerating research through reagent repositories: the genome editing example (2015) (0)
- A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing (2020) (0)
- Genome and Epigenome Editing: A Revolution in Science and Medicine (2014) (0)
- Title ( 47 characters ) : Using FokI-dCas 9 nucleases with truncated gRNAs (2015) (0)
- Abstract 1718: Exploring temozolomide resistance in glioblastoma using a combinatorial zinc-finger library approach (2011) (0)
- Abstract 7: Targeted Mutagenesis of Antithrombin III in Zebrafish Results in Disseminated Intravascular Coagulation and Thrombosis (2013) (0)
- A combined yeast / bacterial two-hybrid system ( YBTH ) : development and evaluation (2009) (0)
- Optimization of AsCas12a for combinatorial genetic screens in human cells (2020) (0)
- Abstract # 10083: From Genotype to Phenotype at a Novel Cholesterol and Myocardial Infarction Locus (2010) (0)
- Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish (2020) (0)
- A Zebrafish Model Of Antithrombin III Deficiency Displays Bleeding and Thrombosis Secondary To Disseminated Intravascular Coagulation (2013) (0)
- CRISPR/Cas9-Mediated Editing of Trinucleotide Repeat Expansion in Myotonic Dystrophy (2017) (0)
- Cholangiocarcinoma Hypersensitivity and SRC Dependence in Intrahepatic Isocitrate Dehydrogenase Mutations Confer Dasatinib (2016) (0)
- Versatile Polymer-Based Nanocarriers for Targeted Therapy and Immunomodulation (2021) (0)
- Publisher Correction: Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing (2020) (0)
- CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells (2021) (0)
- Abstract 5152: Zebrafish models of myeloid malignancies produced through tet2 and asxl1 genomic editing (2015) (0)
- Methodes et compositions de dosage de piegeage par interaction (2001) (0)
- Author Correction: Augmenting and directing long-range CRISPR-mediated activation in human cells (2022) (0)
- Therapeutic base editing of human hematopoietic stem cells (2020) (0)
- Combined +58 and +55 BCL11A enhancer Editing Yields Exceptional Efficiency, Specificity and HbF Induction in Human and NHP Preclinical Models (2021) (0)
- bihíbrido system yeast / bacteria and methods for their use (2005) (0)
- Adeno-associated virus in human liver: natural history and consequences in tumor development (2019) (0)
- CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells (2020) (0)
- Advisory Board and Contents (2020) (0)
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