David Mangelsdorf
#81,142
Most Influential Person Now
American biologist and chemist
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Chemistry Biology
David Mangelsdorf's Degrees
- PhD Biochemistry University of Texas Southwestern Medical Center
- Bachelors Chemistry University of Texas at Austin
Why Is David Mangelsdorf Influential?
(Suggest an Edit or Addition)According to Wikipedia, David J. Mangelsdorf is an American biologist and chemist, currently the Alfred J. Gilman Distinguished Chair in Pharmacology, Raymond and Ellen Willie Distinguished Chair in Molecular Neuropharmacology at University of Texas Southwestern Medical Center. In 2008, he was elected to the National Academy of Sciences. He, along with Steven Kliewer, identified the ligands and physiologic functions of a number of orphan nuclear receptors that then discovered two new signaling pathways mediated by the endocrine factors FGF19 and FGF21, which has become a significant accomplishment in the field. He received BS degrees in biology and chemistry from Northern Arizona University in 1981 and a PhD in biochemistry from the University of Arizona in 1987.
David Mangelsdorf's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The nuclear receptor superfamily: The second decade (1995) (6907)
- The RXR heterodimers and orphan receptors (1995) (3239)
- Identification of a nuclear receptor for bile acids. (1999) (2418)
- Nuclear receptors and lipid physiology: opening the X-files. (2001) (2060)
- 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor (1992) (1704)
- An oxysterol signalling pathway mediated by the nuclear receptor LXRα (1996) (1695)
- Role of LXRs in control of lipogenesis. (2000) (1622)
- Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. (2005) (1560)
- Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ (2000) (1504)
- Nuclear receptor that identifies a novel retinoic acid response pathway (1990) (1443)
- Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα (1998) (1428)
- Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. (2000) (1417)
- Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. (1994) (1398)
- Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling (1992) (1382)
- Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. (2007) (1378)
- Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. (2000) (1317)
- Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. (1992) (1154)
- A Unified Nomenclature System for the Nuclear Receptor Superfamily (1999) (1152)
- Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. (2004) (1118)
- LXR, a nuclear receptor that defines a distinct retinoid response pathway. (1995) (1100)
- Vitamin D Receptor As an Intestinal Bile Acid Sensor (2002) (1023)
- Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network (2006) (958)
- Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. (2006) (919)
- Reciprocal regulation of inflammation and lipid metabolism by liver X receptors (2003) (919)
- Nuclear Receptor Expression Links the Circadian Clock to Metabolism (2006) (918)
- Cloning and expression of full-length cDNA encoding human vitamin D receptor. (1988) (904)
- Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. (1999) (881)
- Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. (2000) (826)
- Nuclear Receptors, RXR, and the Big Bang (2014) (825)
- The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. (2000) (736)
- Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor* (2001) (725)
- Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β* (2002) (711)
- LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. (2001) (663)
- Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. (2004) (647)
- Liver X receptor signaling pathways in cardiovascular disease. (2003) (642)
- FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response (2009) (637)
- A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR (1991) (629)
- Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. (2010) (599)
- LXRS and FXR: the yin and yang of cholesterol and fat metabolism. (2006) (555)
- FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis (2011) (523)
- Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue (2003) (511)
- Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones (2012) (499)
- A Natural Product That Lowers Cholesterol As an Antagonist Ligand for FXR (2002) (498)
- Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. (1987) (496)
- International Union of Pharmacology. LXIII. Retinoid X Receptors (2006) (472)
- Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding (2014) (466)
- Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene (1990) (460)
- Identification of macrophage liver X receptors as inhibitors of atherosclerosis (2002) (452)
- Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans (2006) (448)
- Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. (2002) (447)
- 1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells (1984) (435)
- Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways (2003) (419)
- The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. (2001) (414)
- Human White/Murine ABC8 mRNA Levels Are Highly Induced in Lipid-loaded Macrophages (2000) (405)
- FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. (2014) (393)
- Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. (2012) (392)
- The liver X receptor gene team: Potential new players in atherosclerosis (2002) (391)
- High‐Throughput Real‐Time Quantitative Reverse Transcription PCR (2005) (391)
- FGF21 regulates metabolism and circadian behavior by acting on the nervous system (2013) (381)
- The LXRs: a new class of oxysterol receptors. (1998) (375)
- International Union of Pharmacology. LX. Retinoic Acid Receptors (2006) (375)
- Orphan Nuclear Receptors as eLiXiRs and FiXeRs of Sterol Metabolism* (2001) (368)
- Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. (2008) (367)
- 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen (2007) (351)
- Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries. (1989) (345)
- Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling. (1992) (338)
- The starvation hormone, fibroblast growth factor-21, extends lifespan in mice (2012) (330)
- De-orphanization of Cytochrome P450 2R1 (2003) (326)
- FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway. (2011) (325)
- βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. (2012) (324)
- Liver X Receptor-dependent Repression of Matrix Metalloproteinase-9 Expression in Macrophages* (2003) (323)
- Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ (2012) (322)
- Structural Determinants of Allosteric Ligand Activation in RXR Heterodimers (2004) (312)
- LXRs regulate the balance between fat storage and oxidation. (2005) (307)
- Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. (2007) (304)
- A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. (1999) (302)
- Prevention of cholesterol gallstone disease by FXR agonists in a mouse model (2004) (292)
- Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor (2001) (289)
- A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. (2005) (286)
- Regulation of Lipoprotein Lipase by the Oxysterol Receptors, LXRα and LXRβ* (2001) (279)
- Identification of a hormonal basis for gallbladder filling (2006) (272)
- Bile Acids as Hormones: The FXR-FGF15/19 Pathway (2015) (268)
- Sterol Intermediates from Cholesterol Biosynthetic Pathway as Liver X Receptor Ligands* (2006) (264)
- MicroRNA let-7 regulates 3T3-L1 adipogenesis. (2009) (254)
- Regulated Expression of the Apolipoprotein E/C-I/C-IV/C-II Gene Cluster in Murine and Human Macrophages (2002) (251)
- Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21 (2015) (248)
- A Nuclear Receptor Atlas: macrophage activation. (2005) (248)
- The Drosophila Orphan Nuclear Receptor DHR38 Mediates an Atypical Ecdysteroid Signaling Pathway (2003) (239)
- FGF21 Regulates Sweet and Alcohol Preference. (2016) (236)
- Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. (2003) (236)
- Activation of mammalian retinoid X receptors by the insect growth regulator methoprene. (1995) (230)
- Hepatocyte-Specific Mutation Establishes Retinoid X Receptor α as a Heterodimeric Integrator of Multiple Physiological Processes in the Liver (2000) (227)
- Expression of ABCG5 and ABCG8 Is Required for Regulation of Biliary Cholesterol Secretion* (2005) (225)
- A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling (2007) (224)
- The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. (2011) (213)
- 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. (2008) (202)
- KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference (2016) (198)
- FGF21 contributes to neuroendocrine control of female reproduction (2013) (196)
- Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor (2002) (194)
- Fibroblast growth factor 21: from pharmacology to physiology. (2010) (191)
- Nuclear receptor regulation of cholesterol and bile acid metabolism. (1999) (189)
- Regulation of Bile Acid Synthesis by Fat-soluble Vitamins A and D* (2010) (185)
- Interleukin-1β Suppresses Retinoid Transactivation of Two Hepatic Transporter Genes Involved in Bile Formation* (2000) (185)
- Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. (1997) (182)
- A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma. (2000) (181)
- PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue (2002) (180)
- Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. (2006) (179)
- Prevention of cancer in the next millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research. (1999) (178)
- Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR. (1997) (175)
- International Union of Pharmacology. LXII. The NR1H and NR1I Receptors: Constitutive Androstane Receptor, Pregnene X Receptor, Farnesoid X Receptor α, Farnesoid X Receptor β, Liver X Receptor α, Liver X Receptor β, and Vitamin D Receptor (2006) (172)
- Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. (2012) (172)
- The Phospholipid Transfer Protein Gene Is a Liver X Receptor Target Expressed by Macrophages in Atherosclerotic Lesions (2003) (170)
- Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs). (2001) (164)
- Liver X receptors regulate adrenal cholesterol balance. (2006) (164)
- Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. (2008) (163)
- Nuclear Hormone Receptor Regulation of MicroRNAs Controls Developmental Progression (2009) (163)
- FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia. (2017) (161)
- Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. (2002) (157)
- Retinoid x receptor heterodimers in the metabolic syndrome. (2005) (155)
- Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage. (2007) (151)
- Molecular biology of the vitamin D hormone. (1988) (151)
- The Role of Liver X Receptor-α in the Fatty Acid Regulation of Hepatic Gene Expression* (2003) (145)
- Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function (2003) (145)
- Vitamin A receptors. (2009) (144)
- Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. (2013) (141)
- A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21. (2019) (138)
- Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta. (2001) (137)
- Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg. (1992) (133)
- Pregnane X Receptor Is a Target of Farnesoid X Receptor* (2006) (129)
- Activation of LXRs prevents bile acid toxicity and cholestasis in female mice (2007) (128)
- Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. (2009) (113)
- Nuclear Receptors HNF4α and LRH-1 Cooperate in Regulating Cyp7a1 in Vivo* (2012) (113)
- Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. (2000) (112)
- LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice. (2011) (112)
- Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes (2009) (110)
- Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor. (1991) (108)
- International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. (2006) (108)
- FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption Published, JLR Papers in Press, September 6, 2007. (2007) (107)
- Roles of FGF19 in liver metabolism. (2011) (106)
- Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. (1998) (104)
- Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. (2002) (103)
- All-trans-Retinoic Acid Inhibits Jun N-Terminal Kinase by Increasing Dual-Specificity Phosphatase Activity (1999) (101)
- LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function. (2011) (101)
- Liver X Receptor α Is a Transcriptional Repressor of the Uncoupling Protein 1 Gene and the Brown Fat Phenotype (2008) (98)
- A functional retinoic acid receptor encoded by the gene on human chromosome 12. (1990) (96)
- Stress Pathway Activation Induces Phosphorylation of Retinoid X Receptor* (2000) (95)
- Specific high-affinity binding and biologic action of retinoic acid in human neuroblastoma cell lines. (1983) (93)
- Characterization of a region upstream of exon I.1 of the human CYP19 (aromatase) gene that mediates regulation by retinoids in human choriocarcinoma cells. (1998) (93)
- Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties. (1994) (83)
- Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment (2007) (82)
- Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop. (2015) (80)
- Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution (2016) (80)
- FGF21 Is an Exocrine Pancreas Secretagogue. (2017) (79)
- The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression. (2003) (78)
- FGF21 regulates circadian behavior and metabolism by acting on the nervous system (2013) (76)
- Avian and mammalian receptors for 1,25-dihydroxyvitamin D3: in vitro translation to characterize size and hormone-dependent regulation. (1987) (74)
- In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue. (2007) (74)
- Nuclear receptor regulation of stemness and stem cell differentiation (2009) (73)
- LuXuRies of lipid homeostasis: the unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing. (2002) (72)
- Nuclear Receptor Expression Defines a Set of Prognostic Biomarkers for Lung Cancer (2010) (71)
- Fatty Acid Regulation of Liver X Receptors (LXR) and Peroxisome Proliferator-activated Receptor α (PPARα) in HEK293 Cells* (2002) (71)
- The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol. (2018) (70)
- Expression profiling of nuclear receptors in human and mouse embryonic stem cells. (2009) (66)
- Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals. (2004) (66)
- Isolation of a functional ecdysteroid receptor homologue from the ixodid tick Amblyomma americanum (L.). (1997) (65)
- Evidence for in vivo upregulation of the intestinal vitamin D receptor during dietary calcium restriction in the rat. (1988) (65)
- Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions. (2010) (65)
- DE-ORPHANIZATION OF CYTOCHROME P450 2R1: A MICROSOMAL VITAMIN D 25-HYDROXYLASE (2003) (64)
- The Rieske oxygenase DAF‐36 functions as a cholesterol 7‐desaturase in steroidogenic pathways governing longevity (2011) (61)
- Transcriptional activation of the Drosophila ecdysone receptor by insect and plant ecdysteroids. (2000) (60)
- Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry. (2015) (58)
- Isolation of two functional retinoid X receptor subtypes from the Ixodid tick, Amblyomma americanum (L.) (1998) (57)
- Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions. (2004) (57)
- PPARγ in vagal neurons regulates high-fat diet induced thermogenesis. (2014) (57)
- Partial Resistance to Peroxisome Proliferator–Activated Receptor-α Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism (2008) (55)
- Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. (2004) (54)
- Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release. (2009) (54)
- Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid (2016) (50)
- Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR. (1998) (46)
- Sterols and gene expression: control of affluence. (2000) (44)
- Research Resource: Diagnostic and Therapeutic Potential of Nuclear Receptor Expression in Lung Cancer (2012) (43)
- Nuclear Orphan Receptors: The Search for Novel Ligands and Signaling Pathways (1998) (43)
- Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland. (2006) (43)
- Interaction between vitamin D receptor and vitamin D ligands: two-dimensional alanine scanning mutational analysis. (2003) (43)
- Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. (2007) (38)
- Engineering orthogonal ligand-receptor pairs from "near drugs". (2001) (38)
- The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs). (2002) (38)
- Chromosomal localization of the human retinoid X receptors. (1994) (37)
- The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes (2015) (37)
- AKR1B7 Is Induced by the Farnesoid X Receptor and Metabolizes Bile Acids* (2010) (37)
- High‐Throughput Real‐Time Quantitative Reverse Transcription PCR (2005) (34)
- Nuclear receptors of the enteric tract: guarding the frontier. (2008) (34)
- Methylprednisolone acetate induces, and Δ7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice (2017) (34)
- Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. (2009) (34)
- 42 Retinoid Receptors as Transcription Factors (1992) (33)
- Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor alpha (PPARalpha ) in HEK293 cells. (2002) (33)
- Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone. (1987) (33)
- Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes* (2011) (32)
- Inhibition of growth and cholesterol synthesis in breast cancer cells by oxidation products of β-carotene (1998) (32)
- Establishment of a monoclonal antibody for human LXRα: Detection of LXRα protein expression in human macrophages (2003) (30)
- FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes (2021) (29)
- The retinoid X receptors. Modulators of multiple hormonal signaling pathways. (1994) (29)
- Nuclear Receptor LRH-1 Induces the Reproductive Neuropeptide Kisspeptin in the Hypothalamus (2013) (26)
- Placental expression of the nuclear receptors for oxysterols LXRα and LXRβ during mouse and human development (2005) (25)
- Structural insights into gene repression by the orphan nuclear receptor SHP (2013) (24)
- Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy (2020) (24)
- PPARγ-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice (2018) (23)
- Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development. (2005) (23)
- Retinoid receptors. (1993) (22)
- 22 Marabou Symposium: the changing faces of vitamin D. (2008) (22)
- Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. (2004) (21)
- Sterol-dependent nuclear import of ORP1S promotes LXR regulated trans-activation of apoE. (2012) (20)
- Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila. (2007) (18)
- Retinoic acid receptor expression abnormalities in lung cancer: important clues or major obstacles? (1997) (18)
- The energy balance model of obesity: beyond calories in, calories out. (2022) (16)
- Nuclear receptors: emerging drug targets for parasitic diseases. (2017) (16)
- Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure (2015) (16)
- 1,25-Dihydroxyvitamin D 3 -induced Differentiation in a Human Promyelocytic Leukemia Cell Line (HL-60) : Receptor-mediated Maturation to Macrophage-like Cells (2002) (15)
- The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation (2019) (14)
- SnapShot: Hormones of the Gastrointestinal Tract (2014) (14)
- Identification and quantitation of intracellular retinol and retinoic acid binding proteins in cultured cells. (1984) (13)
- Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells (2016) (13)
- [Regulation of lipid metabolism by the orphan nuclear receptors]. (2001) (12)
- Roles of FGF 19 in Liver Metabolism (2012) (12)
- Modifying ligand specificity of gene regulatory proteins. (2000) (11)
- Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis (2021) (8)
- Identification of a nuclear receptor/coactivator developmental signaling pathway in the nematode parasite Strongyloides stercoralis (2021) (7)
- Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation (2020) (7)
- Molecular cloning and functional analysis of the promoter for bile salt export pump (BSEP) from human and mouse genes: Evidence for transactivation of the humanpromoter by farnesoid-x-receptor/retinoid-x-receptor(FXR/RXR) (2000) (6)
- Trypanosoma brucei: effects of methoprene and other isoprenoid compounds on procyclic and bloodstream forms in vitro and in mice. (1997) (5)
- X-ceptors, nuclear receptors for metabolism (2000) (4)
- Molecular pathogenesis of lung cancer with translation to the clinic: M10-01 (2007) (4)
- The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via transcriptional regulation of meg-8.3 (2021) (3)
- Vitamin D Receptor as a Sensor for Toxic Bile Acids (2005) (3)
- PXR is a target of FXR (2006) (3)
- Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport : A new syndrome of defective FGF 19 release (2010) (3)
- Commentary: the year in nuclear receptor control of metabolism. (2010) (3)
- Abstract 5757: A new functional classification of lung and breast cancers based on siRNA mediated knockdown of 48 NRs and 72 CoRegulators (2012) (3)
- The Role of the Vitamin D Receptor in Bile Acid Homeostasis (2011) (2)
- The 'Nuclear Option' Revisited: Confirmation of Ss-daf-12 Function and Therapeutic Potential in Strongyloides stercoralis and Other Parasitic Nematode Infections. (2022) (2)
- FGF 19 , FGF 21 , and an FGF R 1 / b-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia Graphical (2017) (2)
- FGF 21 Regulates Sweet a nd Alcohol Preference Graphical (2016) (2)
- Pro‐differentiating effects of oxysterols in keratinocytes (2005) (2)
- 1,25-Dihydroxyvitamin D3 receptors in space-flown vs. grounded control rat kidneys. (1985) (2)
- FGF21 Counteracts Alcohol Intoxication by Activating the Noradrenergic Nervous System (2023) (2)
- Abstract 18427: 27-Hydroxycholesterol, the First Identified endogenous SERM, Promotes Atherogenesis in Mice (2010) (2)
- Advances in Brief A Novel Synthetic Oleanane Triterpenoid , 2-Cyano-3 , 12-dioxoolean-1 , 9-dien-28-oic Acid , with Potent Differentiating , Antiproliferative , and Anti-Inflammatory Activity 1 (1999) (2)
- Faculty Opinions recommendation of An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. (2011) (1)
- 1SY01-5 Nuclear receptors as the body's lipid sensors (2003) (1)
- Receptor-Mediated Action of the Vitamin D Hormone (1987) (1)
- Commentary: The Year in Nuclear Receptor Control of Metabolism (2010) (1)
- A natural product that lowers cholesterol as an antagonist for the bile acid receptor FXR (2003) (1)
- Receptors for 1,25-Dihydroxyvitamin D3: Structural Comparisons and Recent Functional Insights (1987) (1)
- 3P-0714 Establishment of a monoclonal antibody for human LXRα: Detection of LXRα protein expression in human macrophages (2003) (1)
- Fibroblast growth factor 21 : from pharmacology to physiology 1 – 4 (2009) (1)
- 1,25-Dihydroxyvitamin D3 receptors: altered functional domains are associated with cellular resistance to vitamin D3. (1986) (1)
- Ligand-binding domain of Drosophila orphan nuclear receptor DHR38 (2003) (0)
- Abstract IA21: Developing a new functional classification of lung cancer based on tumor acquired vulnerabilities. (2014) (0)
- Interview: Interview with David Mangelsdorf for Personalized Medicine. (2011) (0)
- Endocrine Actions of Bile Acids Via Nuclear Receptors and FGFs (2007) (0)
- Richard E and period; Weitzman Award (1998) (0)
- Regulation of metabolism by a neuroendocrine FGF signaling pathway (2014) (0)
- Faculty Opinions recommendation of MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. (2010) (0)
- Regulation of nutrient metabolism by nuclear receptor/FGF signaling pathways (2012) (0)
- Bile Acids and Liver Regeneration (2015) (0)
- Abstract 1228: Peroxisome Proliferator-Activated Receptor {gamma} regulating MnSOD Expression is Essential to Maintain Myocardial Redox Homeostasis (2006) (0)
- Reply to Taubes, Friedman, and Torres-Carot et al. (2022) (0)
- Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-cholestenoic acid (2011) (0)
- Nuclear Receptors: Preface (2003) (0)
- Bile salts control lipogenesis and energy metabolism (2004) (0)
- Abstract 1530: Identification of vulnerabilities in lung cancer via pooled short hairpin RNA screening (2014) (0)
- Abstract LB-521: Expression profile of nuclear receptor superfamily in a lung cancer pathogenesis model (2012) (0)
- Author response: Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure (2015) (0)
- Reflections on the field of metabolism. (2015) (0)
- FUTURE ANNUAL MEETINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH (2017) (0)
- Nuclear receptors and transcriptional control of lipid metabolism (2006) (0)
- FGF21 Counteracts Alcohol Intoxication by Activating Noradrenergic Neurons (2022) (0)
- Crystal Structure of the T3-bound TR-beta Ligand-binding Domain in complex with RXR-alpha (2015) (0)
- expressionII. Cold-adapted function and differential Pancreatic triacylglycerol lipase in a hibernating (2015) (0)
- Transatlantic Medal Lecture (2006) (0)
- A Synthetic Triterpenoid, 2-Cyano-3,12-dioxooleana-1,9-dien-28-oicAcid(CDDO),IsaLigandforthePeroxisomeProliferator-ActivatedReceptor g (2000) (0)
- Abstract 4779: RUVBL1 and RUBVL2 are chromatin remodelers that represent prognostic and novel therapeutic targets for a subset of non-small cell lung cancers (NSCLCs) (2015) (0)
- Abstract 1083: Nuclear receptors as novel targets in ER negative breast cancer (2012) (0)
- Faculty Opinions recommendation of Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. (2009) (0)
- Abstract IA3: Lung cancer stem cells, acquired vulnerabilities, and molecular portraits: Translation to the clinic (2012) (0)
- Alfred Goodman Gilman (1941–2015) (2016) (0)
- Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers (2023) (0)
- Nuclear receptor DAF-12 from parasitic nematode Strongyloides stercoralis in complex with its physiological ligand dafachronic acid delta 7 (2009) (0)
- Nuclear receptors, dietary ligands and lipid metabolism. (2004) (0)
- Cellular programmes for growth, differentiation and neoplasia Helsinki, Finland 19–23 July 1992 (1992) (0)
- An innovative role of thyroid receptor β in triple‐negative breast cancer (58.4) (2014) (0)
- 1041 Characterizing a nuclear hormone receptor pathway that governs parasitic nematode infection using Nippostrongylus brasiliensis as a model (2018) (0)
- An ecological study of zooplankton inhabiting manmade potholes of varying ionic composition (1980) (0)
- Abstract A2-06: An in vivo shRNA functional genomics screen identifies transcriptional and epigenetic regulators that are essential in lung tumorigenesis (2015) (0)
- Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling ( heterodimer / hormone response element / orphan receptor ) (0)
- Abstract 2296: Identification of novel nuclear receptor targets in estrogen receptor negative breast cancer (2011) (0)
- MOLECULAR BIOLOGY AND ACTIONS OF THE VITAMIN-D HORMONE RECEPTOR. (1987) (0)
- Abstract 1238: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer (2010) (0)
- The secret life of FGF21 (2017) (0)
- Identification and quantitation of intracellular retinol and retinoic acid binding proteins in cultured cells. - eScholarship (1984) (0)
- Nuclear receptors, FGFs, and the regulation of nutrient metabolism (2009) (0)
- Crystal Structure of SHP/EID1 (2014) (0)
- Regulation of metabolism by a neuroendocrine FGF signaling pathway (2014) (0)
- Abstract P4-08-09: Targeting Thyroid Receptor b in Estrogen Receptor Negative Breast Cancer (2012) (0)
- Nuclear receptor DAF-12 from parasitic nematode Strongyloides stercoralis in complex with its physiological ligand dafachronic acid delta 4 (2009) (0)
- Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid (2011) (0)
- Erratum: Structural insights into gene repression by the orphan nuclear receptor SHP (Proceedings of the National Academy of Sciences of the United States of America (2014) 111 (839-844) DOI: 10.1073/pnas.1322827111) (2014) (0)
- Abstract 354: Nuclear receptor expression atlas: A theragnostic targets for lung cancer patients (2011) (0)
- Abstract 1474: An RNAi-based functional classification of lung cancer reveals recurring subgroups strongly correlated with EMT status. (2013) (0)
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