Roger L. Williams

Why Is Roger L. Williams Influential?

According to Wikipedia, Roger Lee Williams is a structural biologist and group leader at the Medical Research Council Laboratory of Molecular Biology. His group studies the form and flexibility of protein complexes that associate with and modify lipid cell membranes. His work concerns the biochemistry, structures and dynamics of these key enzyme complexes.

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Roger L. Williams's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells (1988) (2070)
A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling (2006) (1083)
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. (2000) (1079)
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. (1993) (1050)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
The emerging shape of the ESCRT machinery (2007) (719)
Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ (1996) (524)
Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ (2000) (506)
Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage (2013) (503)
A revised structure for fucoidan may explain some of its biological activities. (1993) (485)
Structural insights into phosphoinositide 3-kinase catalysis and signalling (1999) (476)
Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit (2007) (390)
Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinases (2008) (383)
A Role for the ESCRT System in Cell Division in Archaea (2008) (329)
Binding of the PX domain of p47phox to phosphatidylinositol 3,4‐bisphosphate and phosphatidic acid is masked by an intramolecular interaction (2002) (309)
Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4 (2007) (296)
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. (2000) (295)
The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate. (2001) (278)
Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases (2011) (254)
Isolation of embryonic stem (ES) cells in media supplemented with recombinant leukemia inhibitory factor (LIF). (1990) (248)
Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene (1988) (242)
Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2* (1998) (240)
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA) (2012) (227)
ESCRT-I Core and ESCRT-II GLUE Domain Structures Reveal Role for GLUE in Linking to ESCRT-I and Membranes (2006) (223)
ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes. (2004) (222)
Nm23/nucleoside diphosphate kinase: Toward a structural and biochemical understanding of its biological functions (1995) (219)
The p110δ crystal structure uncovers mechanisms for selectivity and potency of novel PI3K inhibitors (2009) (207)
PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. (2003) (205)
Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34 (2010) (203)
Crystal structure of a diabody, a bivalent antibody fragment. (1994) (196)
The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria (2019) (185)
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes (2015) (185)
Empirical solvation models can be used to differentiate native from near‐native conformations of bovine pancreatic trypsin inhibitor (1991) (164)
Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism (2011) (163)
Structure of HIV-1 reverse transcriptase/DNA complex at 7 Å resolution showing active site locations (1992) (153)
Synergy in activating class I PI3Ks. (2015) (153)
Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS (2007) (147)
A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1. (1997) (146)
Catalytic Domain of Phosphoinositide-specific Phospholipase C (PLC) (1998) (146)
Replacements of Single Basic Amino Acids in the Pleckstrin Homology Domain of Phospholipase C-δ1 Alter the Ligand Binding, Phospholipase Activity, and Interaction with the Plasma Membrane* (1998) (144)
Structural role of Sfi1p–centrin filaments in budding yeast spindle pole body duplication (2006) (141)
Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus. (2003) (140)
Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi (2013) (133)
Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24. (2008) (133)
The crystal structure of a human nucleoside diphosphate kinase, NM23-H2. (1995) (128)
ARAP3 Is a PI3K- and Rap-Regulated GAP for RhoA (2004) (127)
Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C. (1997) (121)
Phospholipase C delta 1 requires a pleckstrin homology domain for interaction with the plasma membrane. (1995) (121)
Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer (2016) (119)
Structural Insights into Endosomal Sorting Complex Required for Transport (ESCRT-I) Recognition of Ubiquitinated Proteins* (2004) (119)
Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors (2014) (118)
Calcium-dependent Membrane Penetration Is a Hallmark of the C2 Domain of Cytosolic Phospholipase A2 Whereas the C2A Domain of Synaptotagmin Binds Membranes Electrostatically* (1998) (116)
Mapping the Phospholipid-binding Surface and Translocation Determinants of the C2 Domain from Cytosolic Phospholipase A2 * (1999) (116)
Phosphoinositide 3-kinases as drug targets in cancer. (2005) (116)
Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific diabody. (1996) (115)
Crystal structure of Myxococcus xanthus nucleoside diphosphate kinase and its interaction with a nucleotide substrate at 2.0 A resolution. (1994) (114)
Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs) (2013) (113)
Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C. (1998) (113)
G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness (2012) (111)
Structural insight into the ESCRT‐I/‐II link and its role in MVB trafficking (2007) (110)
Structural basis for the heterodimeric interaction between the acute leukaemia‐associated transcription factors AML1 and CBFβ (2000) (102)
Nature of G1/S cell cycle checkpoint defect in ataxia-telangiectasia. (1995) (101)
Mammalian phosphoinositide-specific phospholipase C. (1999) (101)
5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. (2017) (96)
Activation of GCN2 by the ribosomal P-stalk (2019) (95)
The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain (2012) (93)
Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases (2011) (92)
Production of Leukemia Inhibitory Factor in Escherichia coli by a Novel Procedure and Its Use in Maintaining Embryonic Stem Cells in Culture (1989) (90)
Tyrosine Residues in Phospholipase Cγ2 Essential for the Enzyme Function in B-cell Signaling* (2001) (88)
Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 A: evidence for conformational lability. (1999) (87)
Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase. (2004) (87)
The US regulatory and pharmacopeia response to the global heparin contamination crisis (2016) (86)
Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α (2011) (84)
The structure of a tunicate C-type lectin from Polyandrocarpa misakiensis complexed with D -galactose. (1999) (84)
C2 domain conformational changes in phospholipase C-δ1 (1996) (84)
The 2.0-A resolution crystal structure of a trimeric antibody fragment with noncognate VH-VL domain pairs shows a rearrangement of VH CDR3. (1997) (83)
Structures of closed and open conformations of dimeric human ATM (2017) (82)
C2 domain conformational changes in phospholipase C-delta 1. (1997) (82)
Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division. (2011) (82)
The pleiotropic actions of leukemia inhibitory factor. (1989) (81)
The crystal structure of ribonuclease B at 2.5-A resolution. (1988) (79)
The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. (2010) (76)
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention (2017) (75)
Structural views of phosphoinositide-specific phospholipase C: signalling the way ahead. (1996) (74)
Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS) (2013) (72)
Tor forms a dimer through an N-terminal helical solenoid with a complex topology (2016) (71)
Form and flexibility in phosphoinositide 3-kinases. (2009) (70)
Structural and Membrane Binding Analysis of the Phox Homology Domain of Phosphoinositide 3-Kinase-C2α* (2006) (69)
Formation of germ-line chimeras from embryonic stem cells maintained with recombinant leukemia inhibitory factor. (1990) (67)
Architecture of human Rag GTPase heterodimers and their complex with mTORC1 (2019) (67)
PIKKs--the solenoid nest where partners and kinases meet. (2014) (66)
Increased Hepatic Microsomal Enzyme Activity from Occupational Exposure to Certain Organochlorine Pesticides (1972) (66)
The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells (2019) (63)
PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control (2013) (62)
LIF: a molecule with divergent actions on myeloid leukaemic cells and embryonic stem cells. (1989) (61)
Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract x-rays to 3.5-A resolution. (1991) (60)
The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity (2015) (56)
Structural and Membrane Binding Analysis of the Phox Homology Domain of Bem1p (2007) (56)
Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. (2010) (56)
Strategies for the isolation and characterization of bovine embryonic stem cells. (1994) (55)
VPS34 complexes from a structural perspective (2018) (55)
The intrinsic helix-forming tendency of L-alanine. (1992) (54)
Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex (2016) (53)
A pharmacological map of the PI 3K family defines a role for p 110 alpha in insulin signaling (2017) (53)
The structural basis for mTOR function. (2014) (53)
The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase. (2004) (53)
PTEN regulates cilia through Dishevelled (2015) (51)
Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway. (2016) (51)
Corrigendum: The p110[delta] structure: mechanisms for selectivity and potency of new PI(3)K inhibitors (2010) (50)
A pharmacological map of the PI3-K family defines a role for p110 alpha in signaling: The structure of complex of phosphoinositide 3- kinase gamma with inhibitor PIK-39 (2006) (49)
Faculty Opinions recommendation of Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis. (2001) (44)
Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling (2017) (43)
Structure determination of antiviral compound SCH 38057 complexed with human rhinovirus 14. (1993) (42)
Phosphoinositide-specific phospholipase C delta1 activity toward micellar substrates, inositol 1,2-cyclic phosphate, and other water-soluble substrates: a sequential mechanism and allosteric activation. (1997) (40)
The structural basis of novel endosome anchoring activity of KIF16B kinesin (2007) (39)
Sympathetic hyperplasia and neuroblastomas in transgenic mice expressing polyoma middle T antigen. (1990) (38)
Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology (2019) (38)
A class of highly selective inhibitors bind to an active state of PI3Kγ (2019) (36)
Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11 (2016) (35)
Finding a fitting shoe for Cinderella (2010) (35)
The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site (2014) (33)
A segment of cold shock protein directs the folding of a combinatorial protein. (2005) (33)
Structural Mechanisms of PTEN Regulation. (2019) (32)
Expression of v-src induces aberrant development and twinning in chimaeric mice. (1991) (32)
The 1.9 A crystal structure of a nucleoside diphosphate kinase complex with adenosine 3',5'-cyclic monophosphate: evidence for competitive inhibition. (1995) (32)
The effects of neutral detergents on the crystallization of soluble proteins (1986) (29)
Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes (2020) (27)
Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes (2021) (26)
ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes (2012) (26)
Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors (2018) (26)
Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi (2016) (24)
Analysis of phosphoinositide 3-kinase inhibitors by bottom-up electron-transfer dissociation hydrogen/deuterium exchange mass spectrometry (2017) (23)
Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR. (2019) (22)
Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase g (2000) (22)
Neurological reactions in HIV‐infected patients treated with trichosanthin (1993) (21)
Evolution and assembly of ESCRTs. (2009) (21)
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation (2021) (19)
Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity. (2015) (18)
Rapamycin resistance in ataxia-telangiectasia. (1996) (18)
Phosphoproteomic identification of ULK substrates reveals VPS15‐dependent ULK/VPS34 interplay in the regulation of autophagy (2021) (18)
Crystal Structure of the Two N-terminal Domains of g3p from Filamentous Phage fd at 1.9 A ˚ : Evidence for (1999) (16)
Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies. (2007) (15)
Faculty Opinions recommendation of Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association. (2002) (15)
Electroimmunoassay. A new competitive protein-binding assay using antibody-sensitive electrodes. (1983) (14)
Identification of a Potent Phosphoinositide 3‐Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs (2017) (13)
Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils (2020) (13)
Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System (2018) (11)
Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module. (2016) (11)
Expression of dihydropyridine binding sites in renal epithelial cells. (1997) (11)
A selectable temperature-sensitive v-src Moloney retrovirus. (1988) (11)
Crystallization and preliminary X-ray diffraction analysis of oucleoside diphosphate kinase from Myxococcus xanthus. (1991) (7)
Protein – Coupled Receptor – Mediated Activation of p 110 b by G bg Is Required for Cellular Transformation and Invasiveness (2012) (7)
Structural basis for the interaction of [E160A-E189A]-trichosanthin with adenine. (2003) (6)
Sequential Mechanism and Allosteric Activation of Phosphoinositide-Specific Phospholipase C-δ1 (1998) (6)
PI3Kβ downstream of GPCRs – crucial partners in oncogenesis (2012) (5)
The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism (2020) (5)
Kinases Charging to the Membrane (2010) (5)
Tumour induction in fetal brain transplants exposed to the viral oncogenes polyoma middle T and v-src. (1989) (5)
Membrane trafficking: Arls squeeze the fat out. (2011) (5)
Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α (2013) (5)
Disease Variants of FGFR 3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc 37 in Hsp 90 Chaperone System (4)
Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry. (2016) (4)
Mammalian phosphoinositide-speci¢c phospholipase C (1999) (4)
Allosteric activation of PI3Kα by oncogenic mutations (2013) (4)
Development of selective inhibitors of phosphatidylinositol 3-kinase C2α (2022) (4)
Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace (2021) (4)
Abstract 671: BKM120-mediated G2 arrest: Structural and functional segregation of off-target action and PI3K inhibition (2015) (3)
Polymer fume fever without polymer (1989) (3)
Structural and Membrane Binding Analysis of the PX Domain of Bem 1 p : Basis of Phosphatidylinositol-4-Phosphate Specificity * (2007) (3)
Origin binding by a 100,000-dalton super-T antigen from SVT2 cells (1985) (3)
Abstract 2664: PQR309: Structure-based design, synthesis and biological evaluation of a novel, selective, dual pan-PI3K/mTOR inhibitor (2015) (3)
C-Fos and Polyoma Middle T Oncogene Expression in Transgenic Mice and Embryonal Stem Cell Chimaeras (1989) (2)
Author response: The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells (2019) (2)
Regulation of a Class III PI3K Lipid Kinase (VPS34 Complex II) by the Small G Protein Rab5A: Single Molecule Analysis Reveals a Dual Regulatory Mechanism. (2020) (2)
CALCIUM-PHOSPHOLIPID BINDING DOMAIN FROM CYTOSOLIC PHOSPHOLIPASE A2 (1998) (2)
Structural Principles of Lipid Second Messenger Recognition (2010) (2)
Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs (2022) (2)
Structural Analysis of the Catalysis and Membrane Association of PLC-δ1 (1998) (2)
CRISPR-Cas9-mediated labelling of the C-terminus of human laminin β1 leads to secretion inhibition (2020) (2)
Connecting with an old partner in a new way. (2013) (1)
Acute respiratory distress syndrome in yearling cattle (1993) (1)
STRUCTURAL INSIGHTS INTO PHOSHOINOSITIDE 3-KINASE ENZYMATIC MECHANISM AND SIGNALLING (1999) (1)
Human Inositol (1,4,5) trisphosphate 3-kinase complexed with Mn2+/AMPPNP/Ins(1,4,5)P3 (2004) (1)
Structural and Membrane Binding Analysis of the PX Domain of Phosphoinositide 3-Kinase-C2α * (2006) (1)
[Roles of ESCRT complexes in the MVB pathway]. (2008) (1)
Plasma polymer surface modified expanded polytetrafluoroethylene promotes epithelial monolayer formation in vitro and can be transplanted into the dystrophic rat subretinal space (2020) (1)
Chapter 149 - Structural Principles of Lipid Second Messenger Recognition (2003) (1)
Unsaturation, curvature and charge: effects of membrane parameters on PIK3C3/VPS34-containing complexes (2021) (1)
A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-93 (2006) (1)
Abstract IA02: G-proteins regulating PI3Ks and PI4KIIIβ regulating a G-protein (2015) (1)
THE STRUCTURE OF A BIVALENT DIABODY (1995) (1)
Author response: Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes (2020) (1)
Faculty Opinions recommendation of External lipid PI3P mediates entry of eukaryotic pathogen effectors into plant and animal host cells. (2010) (1)
Structural Mechanisms of PI3K and PTEN Regulation (2015) (1)
The structure of the Bem1p PX domain (2007) (0)
Structure of Phosphoinositide 3-kinase gamma (PI3K) bound to the potent inhibitor PIKin2 (2017) (0)
Faculty Opinions recommendation of Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase. (2014) (0)
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-2-METHYLENE-1,2-CYCLIC-MONOPHOSPHONATE (1997) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW14. (2010) (0)
Faculty Opinions recommendation of The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. (2008) (0)
Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes (2021) (0)
Phosphoinositide 3-kinasey signalling: a structural perspective (2001) (0)
Kinesin 16B Phox-homology domain (KIF16B) (2007) (0)
Faculty Opinions recommendation of Three-dimensional structure of AAA ATPase Vps4: advancing structural insights into the mechanisms of endosomal sorting and enveloped virus budding. (2009) (0)
human p47 PX domain complex with sulphates (2002) (0)
crystal structure of Sfi1p/Cdc31p complex (2006) (0)
Faculty Opinions recommendation of Molecular basis of phosphorylation-induced activation of the NADPH oxidase. (2003) (0)
Closed dimer of human ATM (Ataxia telangiectasia mutated) (2017) (0)
Structure of Lipid Kinase p110b/p85b Elucidates anUnusualSH2-Domain-MediatedInhibitoryMechanism (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with ZSTK474. (2010) (0)
Heterodimer of p40phox and p67phox PB1 domains from human NADPH oxidase (2003) (0)
STRUCTURE OF TC14; A C-TYPE LECTIN FROM THE TUNICATE POLYANDROCARPA MISAKIENSIS (1999) (0)
STRUCTURAL INSIGHT INTO THE INTERACTION BETWEEN ARCHAEAL ESCRT-III AND AAA-ATPASE (2009) (0)
Human Inositol (1,4,5)-trisphosphate 3-kinase substituted with selenomethionine (2004) (0)
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT (1997) (0)
Organic Pollutants Food Web – Specific Biomagnification of Persistent (2007) (0)
Structure of a complex of the golgin-245 GRIP domain with Arl1 (2003) (0)
Faculty Opinions recommendation of Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. (2010) (0)
Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3 (2014) (0)
Challenges at low resolution: crystal structure of the yeast VPS34 complex II. (2016) (0)
STRUCTURE OF A TUNICATE C-TYPE LECTIN COMPLEXED WITH D-GALACTOSE (1999) (0)
Vps36 N-terminal PH domain (2006) (0)
Structure of full-length CTNNBL1 in P43212 space group (2013) (0)
Calmodulin Binds to and Inhibits H‐Ras Activation of PI3K: A Single Molecule Study (2018) (0)
cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases (2019) (0)
Structures of MITD1 (2012) (0)
2 Angstrom X-ray structure of the yeast ESCRT-I Vps28 C-terminus in complex with the NZF-N domain from ESCRT-II (2007) (0)
Stractural insight into the interaction between ESCRT-III and Vps4 (2007) (0)
Structure of the MIT domain from a S. solfataricus Vps4-like ATPase (2007) (0)
Negative stain structure of Vps15/Vps34 complex (2016) (0)
Activation of PI3K by Ras: Single Molecule Studies of the Activation Mechanism (2017) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114. (2010) (0)
ESCRT-I core (2006) (0)
Critical steps in PI3K transition from inhibited to activated state: Structure and dynamics of PI3K regulation (2011) (0)
Cryo electron microscopy of a complex of Tor and Lst8 (2016) (0)
human complex II-BATS bound to membrane-attached Rab5a-GTP (2021) (0)
Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108 (2011) (0)
Complex of [E160A-E189A] trichosanthin and adenine (2003) (0)
Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex (2019) (0)
complex of human phosphoinositide 3-kinase catalytic subunit gamma (p110 gamma) with PIK-284 (2008) (0)
Faculty Opinions recommendation of Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. (2004) (0)
Deciphering the dynamic regulation of phosphoinositide 3‐kinases downstream of G‐protein coupled receptors and receptor tyrosine kinases (1008.1) (2014) (0)
Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941 (2011) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS5. (2010) (0)
Faculty Opinions recommendation of Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission. (2011) (0)
Combinatorial Protein 1b11 (2005) (0)
Structure of the p 110 / p 85 heterodimeric phosphoinositide 3-kinase ( PI 3 K ) (2003) (0)
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH LANTHANUM (1997) (0)
2 Angstrom X-ray structure of the yeast ESCRT-I Vps28 C-terminus (2007) (0)
STRUCTURE OF THE N-TERMINAL TWO DOMAINS OF THE INFECTIVITY PROTEIN G3P OF FILAMENTOUS PHAGE FD (1999) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS15. (2010) (0)
Ras G12V - PI 3-kinase gamma complex (2001) (0)
The crystal structure of endosomal complex ESCRT-II (VPS22/VPS25/VPS36) (2004) (0)
Structure of the PX Domain of Phosphoinositide 3-Kinase-C2alpha (2006) (0)
Annexin-enriched osteoblast-derived vesicles act as an extracellular site of mineral nucleation within developing stem cell cultures (2017) (0)
THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH 3-METHYLADENINE (2010) (0)
TRIVALENT ANTIBODY FRAGMENT (1997) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta. (2010) (0)
X-Ray Diffraction Crystal Structure of the murine PI3K p110delta in complex with a pan inhibitor (2017) (0)
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-1,4,5-TRISPHOSPHATE (1997) (0)
Open protomer of human ATM (Ataxia telangiectasia mutated) (2017) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL06. (2010) (0)
human DEPTOR in a complex with mutant human mTORC1 A1459P (2021) (0)
THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PI-103 (2010) (0)
Faculty Opinions recommendation of Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. (2004) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with PIK-39. (2010) (0)
Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS (2014) (0)
Crystal structure of RagA-Q66L/RagC-T90N GTPase heterodimer complex (2019) (0)
Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing. (2017) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK666. (2010) (0)
Abstract IA10: Structure and dynamics of Rag heterodimers in a complex with mTORC1 (2020) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW30. (2010) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with GDC-0941. (2010) (0)
Structure of a phosphoinositide 3-kinase alpha adaptor-binding domain (ABD) in a complex with the iSH2 domain from p85 alpha (2007) (0)
Structure of the PX domain from p40phox bound to phosphatidylinositol 3-phosphate (2001) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL07. (2010) (0)
Structure of Vps34 complex II from S. cerevisiae. (2015) (0)
A complex of the Vps23 UEV with ubiquitin (2004) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW13. (2010) (0)
Faculty Opinions recommendation of Structure and functional interactions of the Tsg101 UEV domain. (2002) (0)
Structure of Phosphoinositide 3-kinase gamma (PI3K) bound to the potent inhibitor PIKin3 (2017) (0)
The binding of pentaammineruthenium (III) to RNase B and RNase A+d(pA)4 in the crystalline state (1987) (0)
Vilasack Thammavongsa Promote Immune Cell Death Degrades Neutrophil Extracellular Traps to Staphylococcus aureus (2013) (0)
Regulatory Mechanisms of Ca2+, Receptor, Ras, and Lipid Signals that Control Actin Polymerization During Cell Migration (2020) (0)
Prime Time for Dimeric Cytohesins: Surveying the Membrane with One Foot at a Time. (2019) (0)
Abstract A32: The role of the ribosome in GCN2's ability to sense amino acid deprivation and initiate the integrated stress response (2017) (0)
CRISPR-Cas9-mediated labelling of the C-terminus of human laminin β1 leads to secretion inhibition (2020) (0)
Faculty Opinions recommendation of Live-cell visualization of dynamics of HIV budding site interactions with an ESCRT component. (2011) (0)
cryo-EM structure of mTORC1 bound to active RagA/C GTPases (2019) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK654. (2010) (0)
In vitro T lymphopoiesis (2021) (0)
CRYSTAL STRUCTURE OF HRAS(G12V) - ANTI-RAS FV (disulfide free mutant) COMPLEX (2008) (0)
A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-90 (2006) (0)
Crystal structure of HRAS(G12V) - anti-RAS Fv complex (2007) (0)
THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 (2010) (0)
Structural of delta 1-76 CTNNBL1 in space group I222 (2013) (0)
Complex of PI3K gamma with an inhibitor (2008) (0)

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Rutgers University
Cornell University
University of Cambridge

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