Gertrude B. Elion

Gertrude B. Elion's AcademicInfluence.com Rankings

Gertrude B. Elion

Medical

#88

World Rank

#147

Historical Rank

#46

USA Rank

Pharmacology

#15

World Rank

#21

Historical Rank

USA Rank

medical Degrees

Gertrude B. Elion

Biology

#328

World Rank

#595

Historical Rank

#191

USA Rank

Biochemistry

#122

World Rank

#158

Historical Rank

#69

USA Rank

biology Degrees

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Medical
Biology

Gertrude B. Elion's Degrees

Masters Chemistry New York University
PhD Chemistry New York University

Why Is Gertrude B. Elion Influential?

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According to Wikipedia, Gertrude "Trudy" Belle Elion was an American biochemist and pharmacologist, who shared the 1988 Nobel Prize in Physiology or Medicine with George H. Hitchings and Sir James Black for their use of innovative methods of rational drug design for the development of new drugs. This new method focused on understanding the target of the drug rather than simply using trial-and-error. Her work led to the creation of the anti-retroviral drug AZT, which was the first drug widely used against AIDS. Her well known works also include the development of the first immunosuppressive drug, azathioprine, used to fight rejection in organ transplants, and the first successful antiviral drug, acyclovir , used in the treatment of herpes infection.

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Gertrude B. Elion's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. (1977) (1454)
9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group (1978) (1057)
Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine. (1978) (516)
The purine path to chemotherapy (1989) (448)
Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites. (1954) (394)
On the mechanism of inactivation of xanthine oxidase by allopurinol and other pyrazolo[3,4-d]pyrimidines. (1970) (323)
A comparison of the specificities of xanthine oxidase and aldehyde oxidase. (1972) (318)
Mechanism of action and selectivity of acyclovir. (1982) (304)
Metabolic studies of allopurinol, an inhibitor of xanthine oxidase. (1966) (303)
Potentiation by inhibition of drug degradation : 6-substituted purines and xanthine oxidase (1963) (295)
Studies on Condensed Pyrimidine Systems. IX. The Synthesis of Some 6-Substituted Purines (1952) (253)
In vitro susceptibility of varicella-zoster virus to acyclovir (1980) (204)
Effect of acyclovir [9-(2-hydroxyethoxymethyl)guanine] on Epstein-Barr virus DNA replication (1980) (203)
Renal clearance of oxipurinol, the chief metabolite of allopurinol. (1968) (195)
Human hypoxanthine phosphoribosyltransferase. I. Purification, properties, and specificity. (1969) (192)
Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate (1979) (186)
The biochemistry and mechanism of action of acyclovir. (1983) (184)
Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity. (1976) (183)
Acyclovir: Discovery, mechanism of action, and selectivity (1993) (180)
Effect of Acycloguanosine Treatment on Acute and Latent Herpes Simplex Infections in Mice (1979) (179)
Enzymatic and Metabolic Studies with Allopurinol (1966) (172)
Adenosine kinase from rabbit liver. II. Substrate and inhibitor specificity. (1979) (161)
Inhibition of Herpes Simplex Virus-Induced DNA Polymerase Activity and Viral DNA Replication by 9-(2-Hydroxyethoxymethyl) guanine and Its Triphosphate (1979) (158)
Inhibition of purified human and herpes simplex virus-induced DNA polymerases by 9-(2-hydroxyethoxymethyl)guanine triphosphate. Effects on primer-template function. (1981) (153)
Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies. (2005) (147)
6-Mercaptopurine: effects in mouse sarcoma 180 and in normal animals. (1953) (147)
THE FATE OF 6‐MERCAPTOPURINE IN MICE (1954) (145)
Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents. (1988) (144)
Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities. (1981) (143)
Chemical suppression of the immune response. (1963) (140)
The Pharmacology of Azathioprine (1993) (136)
Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information. (1980) (132)
RELATIONSHIP BETWEEN METABOLIC FATES AND ANTITUMOR ACTIVITIES OF THIOPURINES. (1963) (127)
Antagonists of nucleic acid derivatives. VI. Purines. (1951) (124)
Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation. (1979) (122)
THE CHEMISTRY AND BIOCHEMISTRY OF PURINE ANALOGS (1954) (114)
Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts (1996) (112)
Thiopurine biology and pharmacology. (1997) (111)
Acyclovir kinetics after intravenous infusion (1979) (107)
Metabolism of acyclovir in virus-infected and uninfected cells (1981) (103)
STUDIES ON ANALOGS OF PURINES AND PYRIMIDINES (1950) (102)
Ribonucleotide reductase induced by herpes simplex type 1 virus. Characterization of a distinct enzyme. (1983) (101)
The disposition of acyclovir in different species. (1981) (100)
The resolution of active and inactive xanthine oxidase by affinity chromatography. (1972) (95)
Ribonucleosides of allopurinol and oxoallopurinol. Isolation from human urine, enzymatic synthesis, and characterization. (1967) (93)
Antagonists of nucleic acid derivatives. VII. 2, 4-Diaminopyrimidines. (1952) (89)
Metabolic basis for the actions of analogs of purines and pyrimidines. (1965) (86)
Detection of Agents which Interfere with the Immune Response (1961) (84)
Condensed Pyrimidine Systems. XXII. N-Methylpurines (1962) (83)
ANTAGONISTS OF NUCLEIC ACID DERIVATIVES I. THE LACTOBACILLUS CASEI MODEL (1950) (83)
Inhibition of cellular alpha and virally induced deoxyribonucleic acid polymerases by the triphosphate of acyclovir (1980) (80)
Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft. (2000) (79)
Inhibition of human purine nucleoside phosphorylase. Studies with intact erythrocytes and the purified enzyme. (1968) (77)
Metabolism of pyrazolo(3,4-d)pyrimidines in Leishmania braziliensis and Leishmania donovani. Allopurinol, oxipurinol, and 4-aminopyrazolo(3,4-d)pyrimidine. (1979) (67)
Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents (1998) (67)
Preliminary studies on the effect of 2,6‐diaminopurine on transplanted mouse leukemia (1949) (66)
Formation of nucleotides of (6-14C)allopurinol and (6-14C)oxipurinol in rat tissues and effects on uridine nucleotide pools. (1973) (66)
Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice. (1988) (64)
The purine metabolism of a 6-mercaptopurine-resistant Lactobacillus casei. (1953) (63)
Significance of azathioprine metabolites. (1972) (63)
The George Hitchings and Gertrude Elion Lecture. The pharmacology of azathioprine. (1993) (62)
Structure-activity relationships among purines related to 6-mercaptopurine. (1958) (62)
The metabolic fate of the methylnitroimidazole moiety of azathioprine in the rat. (1973) (62)
Species differences in the disposition of acyclovir. (1982) (61)
Rarity of X-linked partial hypoxanthine-guanine phosphoribosyltransferase deficiency in a large gouty population. (1972) (61)
ANTAGONISTS OF NUCLEIC ACID DERIVATIVES (2002) (60)
The Synthesis of 6-Thioguanine (1955) (57)
Observations on the anticancer activity of 6-mercaptopurine. (1954) (56)
Adenosine analogues as substrates and inhibitors of S-adenosylhomocysteine hydrolase in intact lymphocytes. (1980) (55)
Specificity of adenylosuccinate synthetase and adenylosuccinate lyase from Leishmania donovani. Selective amination of an antiprotozoal agent. (1979) (54)
Allopurinol and Other Inhibitors of Urate Synthesis (1978) (53)
Modulation of cyclic AMP metabolism by S-adenosylhomocysteine and S-3-deazaadenosylhomocysteine in mouse lymphocytes. (1980) (53)
Symposium on immunosuppressive drugs. Biochemistry and pharmacology of purine analogues. (1967) (50)
Adenine phosphoribosyltransferase from monkey liver. Specificity and properties. (1969) (50)
Influence of glutamine on the growth of human glioma and medulloblastoma in culture. (1985) (49)
The chemotherapeutic exploitation of virus-specified enzymes. (1980) (49)
The Purine Path to Chemotherapy (Nobel Lecture) (1989) (49)
Pharmacokinetics and bioavailability of acyclovir in the dog. (1981) (48)
BIOLOGICAL ACTIVITIES OF SOME PURINE ARABINOSIDES (1975) (48)
An enzymic synthesis of purine d-Arabinonucleosides (1981) (47)
Guanine phosphoribosyltransferase from Escherichia coli, specificity and properties. (1972) (46)
Identification of 6-methylmercaptopurine ribonucleoside 5'-diphosphate and 5'-triphosphate as metabolites of 6-mercaptopurine in man. (1974) (44)
The incorporation of exogenous purines into pentose nucleic acid by Lactobacillus casei. (1952) (44)
The Effects of Antagonists on the Multiplication of Vaccinia Virus in Vitro. (1949) (44)
Studies on Condensed Pyrimidine Systems. XIII. Some Amino-substituted Derivatives of Guanine and 6-Thioguanine (1956) (44)
Selection and preliminary characterization of acyclovir-resistant mutants of varicella zoster virus. (1982) (43)
Allopurinol and gouty hyperuricemia. Efficacy of a single daily dose. (1975) (43)
2-Fluoroadenosine 3':5'-monophosphate. A metabolite of 2-fluoroadenosine in mouse cytotoxic lymphocytes. (1976) (42)
Inhibition of lymphocyte-mediated cytolysis by adenosine analogs. Biochemical studies concerning mechanism of action. (1978) (42)
Uracil antagonism and inhibition of mammary adenocarcinoma 755. (1958) (42)
XANTHINE AS A PRECURSOR OF NUCLEIC ACID PURINES IN THE MOUSE. (1965) (41)
MICROBIOLOGICAL EFFECTS OF 6‐MERCAPTOPURINE (1954) (41)
Antileishmanial action of 4-thiopyrazolo (3.4-d) pyrimidine and its ribonucleoside. Biological effects and metabolism. (1982) (40)
Studies on Condensed Pyrimidine Systems. XVI. Purines and Thiazolo[5,4-d]pyrimidines from 4-Amino-5-formamido-6-mercaptopyrimidines (1956) (39)
Schedule-dependent activity of irinotecan plus BCNU against malignant glioma xenografts (2000) (39)
Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion. (1989) (38)
Studies on Condensed Pyrimidine Systems. XVII. Some Halogenopurines (1956) (38)
Phosphorylation of acyclovir [9-(2-hydroxyethoxymethyl)guanine] in Epstein-Barr virus-infected lymphoblastoid cell lines (1981) (37)
Studies on Condensed Pyrimidine Systems. XXI. The Isolation and Synthesis of 6-Mercapto-2,8-purinediol (6-Thiouric Acid) (1959) (37)
Preclinical Toxicology Studies with Acyclovir: Acute and Subchronic Tests (1983) (37)
The Synthesis of Some New Pteridines (1947) (37)
The Interaction of Amides with Amines: A General Method of Acylation1 (1943) (36)
The Incorporation of 6-Mercaptopurine-S35 into the Nucleic Acids of Sensitive and Nonsensitive Transplantable Mouse Tumors (1961) (35)
Identification of small DNA fragments synthesized in herpes simplex virus-infected cells in the presence of acyclovir (1984) (34)
Pyrimidine derivatives as antagonists of pteroylglutamic acid. (1948) (32)
The purine path to chemotherapy (1989) (32)
Condensed Pyrimidine Systems. XX. Purines Related to 6-Mercaptopurine and Thioguanine (1959) (32)
Effects of purine antagonists on a diaminopurine-resistant strain of Lactobacillus casei. (1953) (32)
Melphalan transport, glutathione levels, and glutathione-S-transferase activity in human medulloblastoma. (1988) (31)
Antagonists of nucleic acid derivatives. IV. Reversal studies with 2-aminopurine and 2,6-diaminopurine. (1950) (31)
Effects of Xanthine Oxidase Inhibitor on Clinical Manifestations and Purine Metabolism in Gout. (1964) (30)
Effects of purine derivatives and analogues on multiplication of the vaccinia virus. (1950) (29)
2, 4-Diaminopyrimidines as antagonists of folic acid and folinic acid. (1952) (29)
The Formation of 6-Hydroxy- and 7-Hydroxypteridines from 4,5-Diaminopyrimidines and α-Ketoacids and Esters (1950) (29)
THE FATE OF 6‐MERCAPTOPURINE IN MAN (1954) (29)
Studies on 2,6‐diaminopurine and related substances in cultures of embryonic and sarcomatous rodent tissues (1951) (29)
Preclinical toxicology studies with acyclovir: acute and subchronic tests. (1983) (27)
Antagonists of nucleic acid derivatives. II. Reversal studies with substances structurally related to thymine. (1950) (27)
The selectivity of action of an antiherpetic agent, 9‐(2‐hydroxyethoxymethyl) guanine (1999) (27)
Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion. (1989) (27)
Selectivity--key to chemotherapy: presidential address. (1985) (27)
Nobel lecture in physiology or medicine--1988. The purine path to chemotherapy. (1989) (26)
The effects of 6-mercaptopurine on Lactobacillus casei. (1957) (26)
Studies with allopurinol in patients with impaired renal function. (1980) (26)
The Preparation of Primary Amines (1939) (26)
Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft. (1990) (26)
The existence of nonfunctional active sites in milk xanthine oxidase: reaction with functional active site inhibitors. (1970) (26)
The direct thiation of uracils. (1947) (25)
Purine metabolism of a diaminopurine-resistant strain of Lactobacillus casei. (1953) (25)
A Synthesis of 4-Amino-2-thiopyrimidines (1949) (25)
Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 1. Synthesis and activity of some nucleosides of purines and 4-(alkylthio)pyrazolo[3,4-d]pyrimidines. (1982) (24)
Role of antimetabolites in immunosuppression and transplantation (1969) (23)
Uptake, distribution, and anabolism of acyclovir in herpes simplex virus-infected mice (1982) (23)
Disposition in the dog and the rat of 2, 6-diamino-9-(2-hydroxyethoxymethyl)purine (A134U), a potential prodrug of acyclovir. (1983) (23)
Combination chemotherapy in vitro exploiting glutamine metabolism of human glioma and medulloblastoma. (1985) (22)
Deamination Studies on Pyrimidine and Condensed Pyrimidine Systems1,2 (1964) (22)
The Ultraviolet Absorption Spectra of Thiouracils1 (1946) (22)
The quest for a cure. (1993) (22)
Effect of acyclovir combined with other antiherpetic agents on varicella zoster virus in vitro. (1982) (22)
Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors (1998) (22)
Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 2. Synthesis and activity of some nucleosides of 4-(alkylamino)-1H-pyrazolo[3, 4-d]pyrimidines. (1982) (22)
Preclinical Toxicology Studies with Acyclovir: Carcinogenicity Bioassays and Chronic Toxicity Tests (1983) (21)
Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts. (1988) (20)
Formation of 5'-nucleotides of 6-methylmercaptopurine ribonucleoside in human tissues in vitro. (1974) (20)
Metabolism of (6-14-c)allopurinollack of incorporation of allopurinol into nucleic acids. (1975) (20)
Studies on Condensed Pyrimidine Systems. X. Some 1,3-Oxazolo(5,4-d)pyrimidines (1952) (20)
Nobel Lecture. The purine path to chemotherapy. (1989) (20)
Antagonist of nucleic acid derivatives. III. The specificity of the purine requirement of Lactobacillus casei. (1950) (19)
The Identification of “β-Dihydroxanthopterin” as 2,4-Diamino-6-hydroxy-p-oxazino (2,3-d)pyrimidine (1952) (18)
Layer on layer: the Bruce F. Cain memorial Award lecture. (1985) (18)
Immunosuppressive effects of the S-adenosylhomocysteine hydrolase inhibitor, 3-deazaadenosine. (1982) (18)
The limitations of inhibition analysis. (1948) (17)
Studies on Condensed Pyrimidine Systems. VII. Some 8-Arylpurines (1951) (17)
Purine and Pyrimidine Metabolism in Man VII (1991) (17)
Busulfan therapy of central nervous system xenografts in athymic mice (2004) (17)
Purine salvage enzymes in man and Leishmania donovani. (1979) (17)
The metabolism of 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]purine (B.W. 57-323) in man. (1960) (17)
Synthesis of 8-C14 and of S35-6-Mercaptopurine (1954) (16)
Hyperthermia-induced enhancement of melphalan activity against a melphalan-resistant human rhabdomyosarcoma xenograft. (1992) (16)
Actions of purine analogs: enzyme specificity studies as a basis for interpretation and design. (1969) (16)
Historical Background of 6-Mercaptopurine (1986) (16)
Ribonucleotides of allopurinol and oxipurinol in rat tissues and their significance in purine metabolism. (1974) (16)
A summary of investigations with 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]purine (B.W. 57-323) in animals. (1960) (15)
Differential inhibition by azathioprine and 6-mercaptopurine of specific suppressor T cell generation in mice. (1981) (15)
The metabolic disposition of 14C-azathioprine in the dog. (1975) (14)
Effects of Xanthine Oxidase Inhibitors on Purine Catabolism (1968) (14)
On the interconversion of purines by Lactobacillus casei. (1951) (13)
Utilization of some purine riboside derivatives by Lactobacillus casei. (1952) (13)
Effect ofAcycloguanosine Treatment on AcuteandLatent Herpes Simplex Infections inMice (1979) (13)
Preclinical toxicology studies with acyclovir: ophthalmic and cutaneous tests. (1983) (12)
Comparative metabolism of a new antileishmanial agent, allopurinol riboside, in the parasite and the host cell. (1979) (12)
Effect of acyclovir on various murine in vivo and in vitro immunologic assay systems. (1982) (12)
Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma. (1995) (12)
Metabolic studies of high doses of allopurinol in humans. (1984) (11)
The utilization of purine ribotides by Lactobacillus casei. (1953) (11)
Inhibition of lymphocyte-mediated cytolysis by 2-fluoroadenosine--evidence for two discrete mechanisms of drug action. (1978) (11)
Preclinical toxicology studies with acyclovir: carcinogenicity bioassays and chronic toxicity tests. (1983) (11)
Studies on Condensed Pyrimidine Systems. XI. Some 8-Alkyl-7-pteridones1 (1953) (10)
The preparation of xanthopterin. (1949) (10)
CHAPTER 6 – Purine Analogues (1963) (10)
Studies of the effect of 2,6-diaminopurine on the blood and bone marrow of swine. (1950) (10)
An overview of the role of nucleosides in chemotherapy. (1985) (9)
Studies on the mechanism of action of urethane on mammary adenocarcinoma 755. (1960) (9)
Activation and antiviral effect of acyclovir in cells infected with a varicella-like simian virus. (1982) (9)
Mercaptopurine "bioavailability". (1984) (9)
A New Condensed Pyrimidine System: Some p-Oxazino [2,3-d] pyrimidines (1949) (9)
ALLOPURINOL AND IRON STORAGE (1967) (9)
SOME ASPECTS OF IMMUNOSUPPRESSION (1966) (8)
Enhancement of melphalan activity by inhibition of DNA polymerase-α and DNA polymerase-β (1996) (8)
Xanthine phosphoribosyltransferase from Streptococcus faecalis. Properties and specificity. (1974) (8)
Differential interference by azathioprine and 6-mercaptopurine with antibody-mediated immunoregulation: synergism of azathioprine and antibody in the control of an immune response. (1982) (8)
L-Amino acid oxidase (LOX) modulation of melphalan activity against intracranial glioma (1996) (7)
Development of a model of melphalan-induced gastrointestinal toxicity in mice (2004) (7)
Resistance to inhibitors of dihydrofolate reductase in strains of Lactobacillus casei and Proteus vulgaris. (1966) (7)
Enhancement of melphalan-induced gastrointestinal toxicity in mice treated with regional hyperthermia and BSO-mediated glutathione depletion. (1992) (6)
Therapeutic analysis of melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR. (1991) (6)
Studies on 2,6-diaminopurine and related substances in cultures of embryonic and sarcomatous rodent tissues. (1951) (6)
Positive therapeutic interaction between thiopurines and alkylating drugs in human glioma xenografts (2004) (6)
Chronic allopurinol administration and iron storage in mice. (1968) (6)
Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 3. Synthesis and activity of some nucleosides of 4-[(arylalkenyl)thio]pyrazolo[3,4-d]pyrimidines. (1984) (6)
Potentiation in combinations of three biochemically related antimetabolites. (1960) (5)
Synthesis of 6(1‐Methyl‐4‐nitro‐5‐|4,5‐14 C| imidazolyl)thiopurinc (azathioprine) (1973) (5)
Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft (1997) (5)
Allopurinol Ribonucleoside as an Antileishmanial Agent (2002) (5)
Inhibition by acyclovir of herpes simplex virus type 2 morphologically transformed cell growth in tissue culture and tumor‐bearing animals (1983) (4)
Folic acid-like activity from xanthopterin. (1950) (4)
2-Aminopurine as a purine antagonist. (1948) (4)
Drugs in the treatment of hyperuricemia. (1974) (4)
Pharmacologic and physical agents. Immunosuppressive agents. (1977) (4)
Effects of acyclovir and its metabolites on hypoxanthine-guanine phosphoribosyltransferase. (1983) (4)
A radioimmunoassay for herpes simplex virus (HSV) thymidine kinase. (1982) (3)
902 – METABOLIC DISPOSITION AND PHARMACOKINETICS OF 9-(2-HYDROXYETHOXYMETHYL)GUANINE, A NEW ANTIVIRAL DRUG: (1978) (2)
The ultraviolet absorption spectra of thiouracils. (1946) (2)
Suppression of antibody-dependent cellular effector functions by the S-adenosylhomocysteine hydrolase inhibitor, 3-deazaadenosine - potentiation of the effect by L-homocysteine thiolactose (1982) (2)
Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta. (1996) (2)
The effect ofl-amino acid oxidase on activity of melphalan against an intracranial xenograft (2004) (2)
The separation of functional and non-functional xanthine oxidase by affinity chromatography. (1972) (2)
Melphalan cytotoxicity and resistance in medulloblastoma mbt (1987) (2)
Antagonists of nucleic acid derivatives. V. Pteridines. (1951) (2)
A new synthesis of cytosine and 5-methylcytosine. (1949) (2)
Medulloblastoma Xenograft in Athymic Mice Sulfoximine-mediated Glutathione Depletion in a Human Enhanced Melphalan Cytotoxicity following Buthionine Updated (2006) (1)
Derivatives of Condensed Pyrimidine Systems as Antimetabolites (2008) (1)
Selectivityâ€ ” Key to Chemotherapy : Presidential Address 1 (2006) (1)
Effects of glutathione or polyamine depletion on in vivo thermosensitization. (1992) (1)
Comparative antitumor and anti-immune effects. Abstr. (1962) (1)
Immunosuppressive effects of phytohemagglutinin. (1969) (1)
Kidney transplantation: overlooked pioneer. (1991) (1)
Mechanisms of Action of Drugs Affecting Immune Responses (1972) (1)
The lactobacillus casei screening test. (1955) (1)
Additions and Corrections-The Preparation of Xanthopterin (1949) (0)
The Reduction and Reoxidation of Some 8‐Substituted Pteridines (2008) (0)
Biochemical Effects of 6‐Mercaptopurine (2008) (0)
SYNTHESIS OF 6-(1-METHYL-4-NITRO-5-(4,5(14)C)IMIDAZOLYL)THIOPURINE (AZATHIOPRINE) (1974) (0)
Personal Reflections (1999) (0)
Allopurinol-induced suppressor T cell dysfunction. (1982) (0)
Isomeric dihydroxanthopterins. (1949) (0)
130 INFLUENCE OF GLUTAMINE ON GROWTH OF HUMAN MEDULLOBLASTOMA IN CULTURE (1984) (0)
Kidney Transplantation: Overlooked Pioneer (1991) (0)
Chemotherapy, ATP depletion, and gout (1991) (0)
Structural biochemistry, pathogenesis, and metabolism (1991) (0)
Foerfarande Foer framstaellning of the antiviral 9- (beta-D-arabinofuranosyl) purine-5'-Fosfater (1976) (0)
Commentary: ...and French President Voices Support for UNEP. (1999) (0)
Influence of Glutamina on the Growth of Human Glioma and Medulloblastoma in Culture1 (2006) (0)
PYRAZOLO(3,4-D)PYRIMIDINE RIBONUCLEOSIDES AS ANTICOCCIDIALS. 2. SYNTHESIS AND D ACTIVITY OF SOME NUCLEOSIDES OF 4-(ALKYLAMINO)-1H-PYRAZOLO(3,4-D)PYRIMIDINES (1983) (0)
Purine and pyrimidine metabolism in man VII. Part B: structural biochemistry, pathogenesis, and metabolism. (1991) (0)
Meetings: Short courses. (1999) (0)
A summary of investigations with 6- purine (1961) (0)
Additions and Corrections-Isometric Dihydroxanthopterins (1949) (0)
PYRAZOLO(3,4-D)PYRIMIDINE RIBONUCLEOSIDES AS ANTICOCCIDIALS. 1. SYNTHESIS AND D ACTIVITY OF SOME NUCLEOSIDES OF PURINES AND 4-(ALKYLTHIO)PYRAZOLO(3,4-D)PYRIMIDINES (1982) (0)
Synergistic Interactions between Cyclophosphamide or Melphalan and VP-16 in a Human Rhabdomyosarcoma Xenograft 1 (2006) (0)
Some New N‐Methylpurines (2008) (0)

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