John B. Little

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John B. Little is affiliated with the following schools: Boston University, Harvard University

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John B. Little

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Biology

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According to Wikipedia, John B. Little was an American radiobiologist who was the James Stevens Simmons Professor of Radiobiology Emeritus at Harvard T.H. Chan School of Public Health from 2006 until his death in 2020. He graduated from Harvard College and Boston University Medical School .

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John B. Little's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know (2003) (1653)
Induction of sister chromatid exchanges by extremely low doses of alpha-particles. (1992) (917)
Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells. (2001) (602)
Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. (1998) (505)
Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. (2002) (316)
Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect (2003) (314)
Mutation spectrum of the p53 gene in bone and soft tissue sarcomas. (1992) (303)
Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations. (2006) (301)
Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma. (1992) (301)
Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling. (1989) (279)
Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect. (1999) (272)
Potential Role of WAF1/Cip1/p21 as a Mediator of TGF-β Cytoinhibitory Effect (*) (1995) (256)
The Bystander Effect in Radiation Oncogenesis: II. A Quantitative Model (2001) (250)
Relationship between x-ray exposure and malignant transformation in C3H 10T1/2 cells. (1980) (248)
Ku70: a candidate tumor suppressor gene for murine T cell lymphoma. (1998) (242)
Plateau-phase cultures of mammalian cells: an in vitro model for human cancer. (1972) (232)
Repair of Sub-lethal and Potentially Lethal Radiation Damage in Plateau Phase Cultures of Human Cells (1969) (219)
Cell transformation by chemical agents--a review and analysis of the literature. A report of the U.S. Environmental Protection Agency Gene-Tox Program. (1983) (217)
Genomic instability and bystander effects: a historical perspective (2003) (212)
X-ray sensitivity of fifty-three human diploid fibroblast cell strains from patients with characterized genetic disorders. (1980) (207)
X-radiation-induced transformation in a C3H mouse embryo-derived cell line. (1976) (203)
Radiation-induced genomic instability: delayed mutagenic and cytogenetic effects of X rays and alpha particles. (1997) (201)
Repair of potentially lethal radiation damage in vitro and in vivo. (1973) (191)
Association of mammalian cell death with a specific endonucleolytic degradation of DNA (1974) (180)
Delayed reproductive death in X-irradiated Chinese hamster ovary cells. (1991) (171)
Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy. (1980) (169)
Deficient recovery from potentially lethal radiation damage in ataxia telangiectasia and xeroderma pigmentosum (1978) (165)
DNA crosslinking induced by x-rays and chemical agents. (1977) (162)
Stress signaling from irradiated to non-irradiated cells. (2004) (147)
The radiation-induced bystander effect: evidence and significance (2004) (147)
Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotype. (1992) (145)
Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations (1986) (144)
Factors influencing the repair of potentially lethal radiation damage in growth-inhibited human cells. (1973) (136)
Cellular radiation effects and the bystander response. (2006) (136)
HPRT Mutants Induced in Bystander Cells by Very Low Fluences of Alpha Particles Result Primarily from Point Mutations (2001) (132)
Bystander effects: intercellular transmission of radiation damage signals. (2002) (130)
Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses. (2003) (130)
Heat-induced gene expression as a novel targeted cancer gene therapy strategy. (2000) (129)
Timing of the steps in transformation of C3H 10T½ cells by X-irradiation (1984) (126)
Proliferation Kinetics of a Human Breast Cancer Line in Vitro following Treatment with 17β-Estradiol and 1-β-d-Arabinofuranosylcytosine (1978) (125)
Radiation-induced genomic instability. (1998) (124)
Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment. (2005) (123)
Deficient DNA repair in human progeroid cells. (1973) (122)
Inherently radioresistant cells exist in some human tumors. (1985) (120)
Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells (2003) (114)
Cellular repair factors influencing radiocurability of human malignant tumours. (1982) (114)
Comparison of kinetics of X-ray-induced cell killing in normal, ataxia telangiectasia and hereditary retinoblastoma fibroblasts. (1983) (113)
Enhancement of X-ray transformation by 12-O-tetradecanoyl-phorbol-13-acetate in a cloned line of C3H mouse embryo cells. (1978) (112)
The repair of potentially lethal damage in x-irradiated cultures of normal and ataxia telangiectasia human fibroblasts. (1981) (111)
Effect of confluent holding on potentially lethal damage repair, cell cycle progression, and chromosomal aberrations in human normal and ataxia-telangiectasia fibroblasts. (1985) (108)
Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation. (1995) (105)
Effect of tumor promoters, protease inhibitors, and repair processes on x-ray-induced sister chromatid exchanges in mouse cells. (1979) (105)
Effects of X-irradiation on cell-cycle progression, induction of chromosomal aberrations and cell killing in ataxia telangiectasia (AT) fibroblasts. (1985) (104)
Protease inhibitors suppress radiation-induced malignant transformation in vitro (1978) (104)
Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles. (2002) (103)
DNA repair in a Fanconi's anemia fibroblast cell strain. (1979) (103)
Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells. (1990) (103)
Expression of lethal mutations in progeny of irradiated mammalian cells. (1989) (101)
Involvement of membrane signaling in the bystander effect in irradiated cells. (2002) (101)
High and Low Fluences of α-Particles Induce a G1 Checkpoint in Human Diploid Fibroblasts (2000) (100)
Repair of potentially lethal radiation damage in mammalian cells is associated with enhancement of malignant transformation (1975) (98)
Delayed Initiation of DNA Synthesis in Irradiated Human Diploid Cells (1968) (97)
Involvement of the Nonhomologous End Joining DNA Repair Pathway in the Bystander Effect for Chromosomal Aberrations (2003) (97)
Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant. (1999) (96)
X-ray sensitivity of human tumor cells in vitro. (1980) (92)
Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells. (1995) (92)
Evidence that a second event in X-ray-induced oncogenic transformation in vitro occurs during cellular proliferation. (1984) (92)
Radiobiological studies of a high‐energy modulated proton beam utilizing cultured mammalian cells (1975) (90)
p53 is involved in but not required for ionizing radiation-induced caspase-3 activation and apoptosis in human lymphoblast cell lines. (1998) (89)
Delayed reproductive death as a dominant phenotype in cell clones surviving X-irradiation. (1992) (87)
Distribution of polonium-210 in pulmonary tissues of cigarette smokers. (1965) (87)
Molecular genetic analysis of recessive mutations at a heterozygous autosomal locus in human cells. (1990) (87)
Rate of DNA repair in progeric and normal human fibroblasts. (1974) (87)
A comparison of mutation induction at the tk and hprt loci in human lymphoblastoid cells; quantitative differences are due to an additional class of mutations at the autosomal tk locus. (1989) (85)
Skin fibroblasts from a D-deletion type retinoblastoma patient are abnormally X-ray sensitive (1977) (85)
In vitro radiosensitivity of human diploid fibroblasts derived from women with unusually sensitive clinical responses to definitive radiation therapy for breast cancer. (1990) (83)
Regulation by ionizing radiation of CDC2, cyclin A, cyclin B, thymidine kinase, topoisomerase IIalpha, and RAD51 expression in normal human diploid fibroblasts is dependent on p53/p21Waf1. (1998) (83)
Survival of human diploid skin fibroblasts from normal individuals after X-irradiation. (1988) (82)
Morphometric and histological analysis of the lungs of Syrian golden hamsters. (1978) (81)
Changing Views of Cellular Radiosensitivity (1994) (81)
X-ray sensitivity of diploid fibroblasts from patients with hereditary or sporadic retinoblastoma. (1978) (81)
Radiosensitivity in vitro of human soft tissue sarcoma cell lines and skin fibroblasts derived from the same patients. (1993) (81)
Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells (1997) (79)
Relationship of DNA repair to chromosome aberrations, sister-chromatid exchanges and survival during liquid-holding recovery in X-irradiated mammalian cells. (1980) (79)
Relationship between γ-ray-induced G2/M Delay and Cellular Radiosensitivity (1994) (78)
ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation (2000) (77)
Evidence for linear response for the induction of mutations in human cells by x-ray exposures below 10 rads. (1985) (77)
Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures. (2001) (77)
Prolonged cell cycle delay in radioresistant human cell lines transfected with activated ras oncogene and/or simian virus 40 T-antigen. (1993) (76)
Effects of protease inhibitors on radiation transformation in vitro. (1981) (76)
Levels of γ-H2AX Foci after Low-Dose-Rate Irradiation Reveal a DNA DSB Rejoining Defect in Cells from Human ATM Heterozygotes in Two AT Families and in Another Apparently Normal Individual (2006) (74)
Genomic instability and radiation. (2003) (73)
Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response (2014) (71)
Evidence that DNA double-strand breaks initiate the phenotype of delayed reproductive death in Chinese hamster ovary cells. (1992) (71)
Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines. (1995) (69)
Normal repair of DNA single-strand breaks in patients with ataxia telangiectasia. (1980) (68)
DNA-protein cross-linking by chemical carcinogens in mammalian cells. (1979) (68)
Induction of oncogenic transformation in vitro by ultraviolet light (1976) (67)
Role of free radicals in the initiation and promotion of radiation transformation in vitro. (1984) (67)
Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro (1992) (66)
Quantitative studies of radiation transformation with the A31-11 mouse BALB/3T3 cell line. (1979) (66)
In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H/10T1/2 cells transformed in vitro by X-rays. (1994) (65)
Repair of potentially-lethal radiation damage in mammalian cells: enhancement by conditioned medium from stationary cultures. (1971) (64)
Abrogation of P53 function by transfection of HPV16 E6 gene does not enhance resistance of human tumour cells to ionizing radiation. (1996) (64)
Toxicity and mutagenicity of X-rays and [125I]dUrd or [3H]TdR incorporated in the DNA of human lymphoblast cells. (1983) (64)
Relationship between DNA repair capacity and cellular aging. (1976) (64)
Cellular, molecular, and carcinogenic effects of radiation. (1993) (64)
Cellular effects of ionizing radiation. (1968) (63)
Radiation carcinogenesis. (2000) (62)
Oncogenic transformation of mouse BALB/3T3 cells by plutonium-238 alpha particles. (1983) (62)
A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status (2008) (62)
Radiation sensitivity of cell strains from families with genetic disorders predisposing to radiation-induced cancer. (1989) (61)
Molecular and biochemical analyses of spontaneous and X-ray-induced mutants in human lymphoblastoid cells. (1987) (61)
The in vitro genetic effects of fibrous erionite and crocidolite asbestos. (1986) (61)
In vitro radiosensitivity of human dipliod fibroblasts derived from patients with unusual clinical responses to radiation. (1976) (60)
Low dose exposure to sodium arsenite synergistically interacts with UV radiation to induce mutations and alter DNA repair in human cells. (2004) (60)
Overview of radiosensitivity of human tumor cells to low-dose-rate irradiation. (2008) (60)
Transient failure to dephosphorylate the cdc2-cyclin B1 complex accompanies radiation-induced G2-phase arrest in HeLa cells. (1995) (60)
Suppression of cytotoxic effect of mitomycin-C by superoxide dismutase in Fanconi's anemia and dyskeratosis congenita fibroblasts. (1983) (59)
CDC2 is down-regulated by ionizing radiation in a p53-dependent manner. (1997) (59)
Molecular characterization of thymidine kinase mutants of human cells induced by densely ionizing radiation. (1989) (59)
Low-Dose Radiation-Induced Senescent Stromal Fibroblasts Render Nearby Breast Cancer Cells Radioresistant (2009) (59)
The Role of Gap Junction Communication and Oxidative Stress in the Propagation of Toxic Effects among High-Dose α-Particle-Irradiated Human Cells (2011) (58)
Response of X-ray-sensitive CHO mutant cells (xrs-6c) to radiation. II. Relationship between cell survival and the induction of chromosomal damage with low doses of alpha particles. (1991) (57)
Response of human osteosarcoma in vitro to irradiation: evidence for unusual cellular repair activity. (1977) (56)
Glycolytic metabolism influences global chromatin structure (2015) (56)
In vitro cellular radiosensitivity of human malignant tumors. (1976) (56)
Investigation of the mechanism for enhancement of radiation transformation in vitro by 12-O-tetradecanoylphorbol-13-acetate. (1980) (54)
Design of a benchtop alpha particle irradiator. (1995) (53)
In vitro radiosensitivity of human leukemia cell lines. (1981) (52)
Site-specific chromosomal rearrangements induced in human diploid cells by x-irradiation. (1986) (51)
DNA damage induced in human diploid cells by decay of incorporated radionuclides. (1984) (51)
Relative biological effectiveness of the 10B(n, alpha)7 Li reaction in HeLa cells. (1970) (51)
Cultured diploid fibroblasts from patients with the nevoid basal cell carcinoma syndrome are hypersensitive to killing by ionizing radiation. (1983) (51)
Radiobiological studies of a high-energy modulated proton beam utilizing cultured mammalian cells. (1975) (51)
Role of Homologous Recombination in the Alpha-Particle-Induced Bystander Effect for Sister Chromatid Exchanges and Chromosomal Aberrations (2005) (50)
Molecular characterization of hprt mutants induced by low- and high-LET radiations in human cells. (1990) (49)
Induction of chromosome aberrations and sister chromatid exchanges by X rays in density-inhibited cultures of mouse 10T1/2 cells. (1981) (49)
Requirement of wild‐type p53 protein for maintenance of chromosomal integrity (2000) (48)
Induction of genetic instability by ionizing radiation. (1999) (48)
Abnormal sensitivity of diploid skin fibroblasts from a family with gardner's syndrome to the lethal effects of X-irradiation, ultraviolet light and mitomycin-C. (1980) (48)
Sensitivity of human diploid fibroblast cell strains from various genetic disorders to acute and protracted radiation exposure. (1990) (47)
The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process. (1982) (47)
Effect of dose rate on the survival of irradiated human skin fibroblasts. (1992) (47)
Effect of time and duration of exposure to 12-O-tetradecanoylphorbol-13-acetate on x-ray transformation of C3H 10T 1/2 cells. (1980) (47)
Differential response of rapidly and slowly proliferating human cells to X irradiation. (1969) (47)
A role for p53 in DNA end rejoining by human cell extracts. (1997) (46)
Life-cycle dependence of repair of potentially-lethal radiation damage. (1973) (46)
Factors influencing the induction of sister chromatid exchanges in mammalian cells by 12-O-tetradecanoyl-phorbol-13-acetate. (1981) (46)
X rays induce interallelic homologous recombination at the human thymidine kinase gene (1992) (46)
Interactions between polonium-210 alpha-radiation, benzo(a)pyrene, and 0.9% NaCl solution instillations in the induction of experimental lung cancer. (1978) (45)
Detection of ataxia telangiectasia heterozygous cell lines by postirradiation cumulative labeling index: measurements with coded samples. (1987) (45)
Iodine-125-labelled tamoxifen is differentially cytoxic to cells containing oestrogen receptors. (1980) (44)
Modification of radiosensitivity and recovery from X ray damage in vitro by retinoic acid. (1989) (44)
Locus specificity for mutation induction in human cells exposed to accelerated heavy ions. (1989) (44)
Role and regulation of p53 during an ultraviolet radiation-induced G1 cell cycle arrest. (2000) (44)
Effect of dose rate on the induction of experimental lung cancer in hamsters by alpha radiation. (1985) (43)
DNA repair and malignant transformation: effect of X irradiation, 12-O-tetradecanoyl-phorbol-13-acetate, and protease inhibitors on transformation and sister-chromatid exchanges in mouse 10T 1/2 cells. (1979) (43)
Induction of chromosomal aberrations and sister chromatid exchanges by alpha particles in density-inhibited cultures of mouse 10T1/2 and 3T3 cells. (1990) (42)
Normal cytotoxic response of skin fibroblasts from patients with Li-Fraumeni familial cancer syndrome to DNA-damaging agents in vitro. (1987) (42)
Characteristics of human diploid fibroblasts transformed in vitro by chemical carcinogens. (1983) (41)
Molecular analysis of DNA isolated from the different stages of X‐ray‐lnduced transformation in vitro (1989) (40)
Respiratory Tract Tumors in Hamsters Induced by Benzo(a)pyrene and 210Po α-Radiation (1974) (39)
Radiosensitivities of ten apparently normal human diploid fibroblast strains to cell killing, G2-phase chromosomal aberrations, and cell cycle delay. (1988) (39)
Persistently elevated sister chromatid exchanges in ethylene oxide-exposed primates: the role of a subpopulation of high frequency cells. (1988) (39)
Absence of a radiation-induced first-cycle G1-S arrest in p53+ human tumor cells synchronized by mitotic selection. (1998) (39)
Transformation and radiosensitivity of human diploid skin fibroblasts transfected with SV40 T-antigen mutants defective in RB and P53 binding domains. (1992) (39)
Relationship of enhanced survival during confluent holding recovery in ultraviolet-irradiated human and mouse cells to chromosome aberrations, sister chromatid exchanges, and DNA repair. (1982) (38)
Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy. (1984) (38)
Lung cancer induced in hamsters by low doses of alpha radiation from polonium-210. (1975) (38)
The response of proliferating cell nuclear antigen to ionizing radiation in human lymphoblastoid cell lines is dependent on p53. (1998) (37)
Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene (1992) (37)
Regulation of normal cell cycle progression by flavin-containing oxidases (2008) (36)
Epidermal growth factor, like tumor promoters, enhances viral and radiation-induced cell transformation. (1981) (36)
Histochemical, light and electron microscopic study of polonium-210 induced peripheral tumors in hamster lungs: evidence implicating the Clara cell as the cell of origin. (1977) (36)
LAURISTON S. TAYLOR LECTURE: NONTARGETED EFFECTS OF RADIATION: IMPLICATIONS FOR LOW-DOSE EXPOSURES (2006) (36)
Induction of cytotoxicity, mutation, cytogenetic changes, and neoplastic transformation by benzo(a)pyrene and derivatives in C3H/10T1/2 clone 8 mouse fibroblasts. (1982) (35)
The effect of X irradiation on the progression of mouse 10T1/2 cells released from density-inhibited cultures. (1984) (35)
Dexamethasone-Induced Enhancement of Resistance to Ionizing Radiation and Chemotherapeutic Agents in Human Tumor Cells (1999) (34)
Inherent cellular radiosensitivity of human tumors of varying clinical curability. (1976) (34)
A defect in DNA double strand break processing in cells from unaffected parents of retinoblastoma patients and other apparently normal humans. (2007) (34)
A system for assaying homologous recombination at the endogenous human thymidine kinase gene. (1991) (34)
Influence of noncarcinogenic secondary factors on radiation carcinogenesis. (1981) (34)
Transformation and radiosensitivity of human diploid skin fibroblasts transfected with activated ras oncogene and SV40 T-antigen. (1992) (34)
Low dose ionizing radiation‐induced activation of connexin 43 expression (2003) (34)
Fraction size and the repair of potentially lethal radiation damage in a human melanoma cell line. Possible implications for radiotherapy. (1982) (33)
Resistance of plateau-phase human normal and xeroderma pigmentosum fibroblasts to the cytotoxic effect of ultraviolet light. (1979) (33)
Human tumor cells segregate into radiosensitivity groups that associate with ATM and TP53 status (2007) (32)
γ-H2AX Foci after Low-Dose-Rate Irradiation Reveal Atm Haploinsufficiency in Mice (2006) (32)
Differential Role of DNA-PKcs Phosphorylations and Kinase Activity in Radiosensitivity and Chromosomal Instability (2011) (32)
Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination. (2007) (32)
Differential effects of radical scavengers on X-ray-induced mutation and cytotoxicity in human cells. (1987) (31)
Proliferative and morphological changes in the pulmonary epithelium of the Syrian golden hamster during carcinogenesis initiated by 210Po alpha alpha-radiation. (1982) (31)
Hypersensitivity of ataxia telangiectasia skin fibroblasts to DNA alkylating agents. (1982) (31)
Mechanisms of human cell neoplastic transformation: X-ray-induced abnormal clone formation in long-term cultures of human diploid fibroblasts. (1985) (31)
Potentially lethal damage repair as a possible determinant of human tumour radiosensitivity. (1984) (30)
Relationship between gamma-ray-induced G2/M delay and cellular radiosensitivity. (1994) (30)
Induction of ouabain-resistant mutations in C3H 10T1/2 mouse cells by ultraviolet light. (1978) (30)
Suppression of Apoptosis and Clonogenic Survival in Irradiated Human Lymphoblasts with Different TP53 Status (2002) (30)
Rapid and slow DNA rejoining in nondividing human diploid fibroblasts treated with bleomycin and ionizing radiation. (1985) (30)
Induction of Mutations by Bismuth-212 α Particles at Two Genetic Loci in Human B-Lymphoblasts (1992) (30)
Variations in radiosensitivity among individuals: a potential impact on risk assessment? (2009) (29)
Letter: Oncogenic transformation in vitro after split-dose x-irradiation. (1976) (29)
X-rays mutate human lymphoblast cells at genetic loci that should respond only to point mutagens. (1986) (29)
Characterization of a quantitative assay for the in vitro transformation of normal human diploid fibroblasts to anchorage independence by chemical carcinogens. (1983) (29)
Chromosome 14 marker appearance in a human B lymphoblastoid cell line of nonmalignant origin. (1986) (29)
Malignant transformation induced by incorporated radionuclides in BALB/3T3 mouse embryo fibroblasts. (1982) (29)
Loss of normal G1 checkpoint control is an early step in carcinogenesis, independent of p53 status. (1999) (28)
Defective reactivation of ultraviolet light-irradiated herpesvirus by a Bloom's syndrome fibroblast strain. (1979) (28)
Genomic rearrangements in mouse C3H/10T1/2 cells transformed by X-rays, UV-C, and 3-methylcholanthrene, detected by a DNA fingerprint assay. (1992) (28)
Enhancement of UV-induced unscheduled DNA synthesis by hydroxyurea. Demonstration by combined biochemical and autoradiographic techniques. (1977) (28)
Progeria cells are stimulated to repair DNA by co-cultivation with normal cells. (1976) (27)
Recovery from ozone-induced injury in the lungs of the Syrian golden hamster. (1982) (27)
Response of human tumor cells of varying radiosensitivity and radiocurability to fractionated irradiation. (1999) (27)
Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells. (1990) (27)
Repair of potentially lethal X ray damage and possible applications to clinical radiotherapy. (1983) (27)
Low-dose radiation effects: interactions and synergism. (1990) (27)
Expression of CONNEXIN 43 Is Highly Sensitive to Ionizing Radiation and Other Environmental Stresses 1 (2003) (26)
Retinoblastoma, chromosome 13, and in vitro cellular radiosensitivity. (1979) (26)
High and low fluences of alpha-particles induce a G1 checkpoint in human diploid fibroblasts. (2000) (26)
Some unsolved problems and unresolved issues in radiation cytogenetics: a review and new data on roles of homologous recombination and non-homologous end joining. (2010) (26)
Polonium-210 in Bronchial Epithelium of Cigarette Smokers (1967) (26)
Genotype-dependent radiosensitivity: Clonogenic survival, apoptosis and cell-cycle redistribution (2008) (26)
New findings in the chromosome 13 long-arm deletion syndrome and retinoblastoma. (1979) (26)
Irradiation of primary human amnion cell cultures: effects on DNA synthesis and progression through the cell cycle. (1970) (26)
AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX–MDM2 complex (2017) (25)
Proliferation kinetics of density-inhibited cultures of human cells, a complex invitro cell system. (1973) (24)
Radiation-induced irreversible g(0) g(1) block is abolished in human-diploid fibroblasts transfected with the human papilloma-virus e6 gene - implication of the p53-cip1 waf1 pathway. (1995) (24)
Failla Memorial Lecture. Changing views of cellular radiosensitivity. (1994) (24)
Persistence of X-ray-induced chromosomal rearrangements in long-term cultures of human diploid fibroblasts. (1984) (24)
Hypersensitivity of cells from a new chromosomal-breakage syndrome to DNA-damaging agents. (1986) (24)
Promotion of x-ray transformation in vitro. (1982) (24)
Radioresistance in some human tumor cells conferred in vitro by repair of potentially lethal X-ray damage. (1982) (23)
The transport and localization of benzo(a)pyrene-hematite and hematite-210Po in the hamster lung following intratracheal instillation. (1974) (23)
Rapid recovery in plateau-phase mammalian cells. (1979) (23)
Multiple manifestations of X‐ray–induced genomic instability in Chinese hamster ovary (CHO) cells (2001) (22)
Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus (1994) (22)
MECHANISMS OF HUMAN CELL NEOPLASTIC TRANSFORMATION: RELATIONSHIP OF SPECIFIC ABNORMAL CLONE FORMATION TO PROLONGED LIFESPAN IN X‐IRRADIATED HUMAN DIPLOID FIBROBLASTS (1985) (22)
The effect of dietary fatty acids and tocopherol on the radiosensitivity of mammalian erythrocytes. (1973) (21)
Acute leukemia after radiotherapy in a patient with Turcot's syndrome. Impaired colony formation in skin fibroblast cultures after irradiation. (1983) (21)
Response of dermal fibroblast cultures from patients with unusually severe responses to radiotherapy and from ataxia telangiectasia heterozygotes to fractionated radiation. (1995) (21)
What are the risks of low-level exposure to alpha radiation from radon? (1997) (21)
Study of basal cell nevus syndrome fibroblasts after treatment with DNA-damaging agents. (1984) (21)
Toxicity and mutagenicity of low dose rates of ionizing radiation from tritiated water in human lymphoblastoid cells. (1985) (21)
Ultrarapid recovery from lethal effects of bleomycin and gamma-radiation in stationary-phase human diploid fibroblasts. (1985) (21)
BIO-ASSAY FOR ANTIDIURETIC ACTIVITY IN BLOOD OF UNDISTURBED RATS. (1964) (20)
Mutagenesis and lethality following S phase irradiation of xeroderma pigmentosum and normal human diploid fibroblasts with ultraviolet light. (1983) (20)
Malignant transformation by the DNA-protein crosslinking agent trans-Pt(II) diamminedichloride. (1980) (20)
Antidiuretic hormone inactivation by isolated perfused rat liver. (1966) (20)
Radiation-induced DNA degradation in human cells: lack of evidence following moderate doses of x-rays. (1968) (20)
Induction of apoptosis in human tumor cells after exposure to Auger electrons: comparison with γ-ray exposure (2006) (20)
Hyperthermic modulation of X-ray-induced oncogenic transformation in C3H 10T1/2 cells. (1981) (19)
A Low-dose Arsenic-induced p53 Protein-mediated Metabolic Mechanism of Radiotherapy Protection* (2014) (19)
Unexpected resistance to x-irradiation in a strain of hybrid mammalian cells. (1972) (19)
Enhancement of survival of X-irradiated mammalian cells by the uncoupler of oxidative phosphorylation, m-chloro carbonyl cyanide phenylhydrazone. (1977) (19)
Induction of sister-chromatid exchanges by DNA-damaging agents and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in synchronous Chinese hamster ovary (CHO) cells. (1983) (19)
Sister-chromatid exchanges in lymphocytes from styrene-exposed boat builders. (1990) (19)
CIRCULATING ANTIDIURETIC HORMONE IN RATS: EFFECTS OF DIETARY ELECTROLYTES AND PROTEIN. (1964) (19)
Effects of cigarette smoking and solvent exposure on sister chromatid exchange frequency in painters (1988) (19)
AUTORADIOGRAPHY USING DRY MOUNTED FREEZE-DRIED SECTIONS FOR LOCALIZATION OF CARCINOGENS IN THE LUNG (1974) (19)
Mutation Spectrum of the p 53 Gene in Bone and Soft Tissue Sarcomas 1 (2006) (19)
Fluorescent light induces malignant transformation in mouse embryo cell cultures. (1980) (19)
Identification of ataxia telangiectasia heterozygotes by flow cytometric analysis of X-ray damage. (1989) (19)
Induction of neoplastic transformation by low-dose-rate exposure to tritiated water. (1986) (18)
Epidermal growth factor induces cytogenetic damage in mammalian cells. (1987) (18)
Inhibition of postreplication repair and the enhancement of induction of SV40 virus from transformed hamster kidney cells. (1978) (18)
222Rn daughter dosimetry in the Syrian golden hamster lung. (1978) (18)
Characterization and radiobiologic parameters of medulloblastoma in vitro (1977) (18)
Genotoxic and mutagenic effects of the diagnostic use of thallium-201 in nuclear medicine. (1991) (18)
Correlation of in vitro transformation with in vivo tumorigenicity in 10T1/2 mouse cells exposed to UV light. (1979) (18)
Starvation for arginine and glutamine sensitizes human diploid cells to the transforming effects of N-acetoxy-2-acetylaminofluorene. (1981) (18)
Efficient Immortalization by SV40 T DNA of Skin Fibroblasts From Patients With Wilms' Tumor Associated With Chromosome 11p Deletion (1989) (18)
Abnormal sensitivity of skin fibroblasts from familial polyposis patients to DNA alkylating agents. (1982) (18)
Heterogeneous response to X-ray and ultraviolet light irradiations of cultured skin fibroblasts in two families with Gardner's Syndrome. (1982) (18)
Recombinagenic activity of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate in human lymphoblastoid cells. (1995) (17)
Differing effects of breast cancer 1, early onset (BRCA1) and ataxia‐telangiectasia mutated (ATM) mutations on cellular responses to ionizing radiation (2003) (17)
The effect of caffeine on the ultraviolet light induction of SV40 virus from transformed hamster cells. (1976) (17)
Abnormalities of human chromosome 13 and in vitro radiosensitivity; a study of 19 fibroblast strains. (1981) (16)
A comparison of the lethal effects of intracellular radionuclides in human and rodent cells. (1983) (16)
The Impact of Biology on Risk Assessment--workshop of the National Research Council's Board on Radiation Effects Research. July 21-22, 1997, National Academy of Sciences, Washington, DC. (1998) (16)
Single-strand conformation polymorphisms can be used to detect T cell receptor gene rearrangements: an application to the in vivo hprt mutation assay. (1991) (16)
Effect of duration of exposure to benzo(a)pyrene diol-epoxide on neoplastic transformation, mutagenesis, cytotoxicity, and total covalent binding to DNA of rodent cells. (1988) (16)
Response of plateau-phase mouse embryo fibroblasts to ultra-violet light. (1979) (16)
Induction of DNA double-strand breaks by restriction enzymes in X-ray-sensitive mutant Chinese hamster ovary cells measured by pulsed-field gel electrophoresis. (1995) (16)
Application of denaturing gradient gel blots to detect p53 mutations in X‐ray—transformed mouse C3H 10T1/2 clones (1993) (15)
Serial sacrifice study of pathogenesis of 210Po-induced lung tumors in Syrian golden hamsters. (1978) (15)
Induction of apoptosis in human tumor cells after exposure to Auger electrons: comparison with gamma-ray exposure. (2006) (15)
Radio‐induced modulation of transforming growth factor β1 sensitivity in a p53 wild‐type human colorectal‐cancer cell line (1996) (15)
Enhancement of benzo[a]pyrene-induced sister chromatid exchanges in lymphocytes from cigarette smokers occupationally exposed to asbestos. (1986) (15)
Prolongation of postmitotic life-span of primary human amnion cells in vitro by hydrocortisone. (1967) (15)
Radiation sensitivity of fibroblast strains from patients with Usher's syndrome, Duchenne muscular dystrophy, and Huntington's disease. (1987) (15)
Efficient mutation induction by 125I and 131I decays in DNA of human cells. (1990) (15)
Multiple abnormalities in the ultraviolet light response of cultured fibroblasts derived from patients with the basal cell nevus syndrome. (1988) (14)
Influence of confluent holding time on UV light mutagenesis in human diploid fibroblasts. (1983) (14)
Differing Responses of Nijmegen Breakage Syndrome and Ataxia Telangiectasia Cells to Ionizing Radiation (2002) (14)
Enhancement of survival of irradiated plateau phase cells by dinitrophenol: effect of dose-rate and cell strain. (1976) (14)
Cellular mechanisms of oncogenic transformation in vitro. (1985) (14)
Alternation of chemotherapy and radiotherapy in cancer management. I. Summary of the Division of Cancer Treatment Workshop. (1985) (14)
Repair of fractionated radiation in plateau phase cultures of human tumor cells and human multicellular tumor spheroids. (1984) (14)
Molecular structural analysis of 417 HPRT mutations induced by restriction endonucleases in Chinese hamster ovary (CHO) cells. (1995) (14)
Principal Cellular and Tissue Effects of Radiation (2003) (14)
An EZH2-mediated epigenetic mechanism behind p53-dependent tissue sensitivity to DNA damage (2018) (14)
Differential Radiosensitivity Phenotypes of DNA-PKcs Mutations Affecting NHEJ and HRR Systems following Irradiation with Gamma-Rays or Very Low Fluences of Alpha Particles (2014) (14)
Antidiuretic hormone bio-assay in rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain). (1967) (13)
Localization of polycyclic hydrocarbon carcinogens in the lung following intratracheal instillation in gelatin solution. (1975) (13)
Letter: Gamma-irradiation of mammalian beating heart cells in vitro. Effects on cellular function. (1975) (13)
DNA repair defect in progeric cells. (1978) (13)
X-ray induction of microsatellite instability at autosomal loci in human lymphoblastoid WTK1 cells. (2001) (13)
BIOLOGICAL CONSEQUENCES OF X-RAY INDUCED DNA DAMAGE AND REPAIR PROCESSES IN RELATION TO CELL KILLING AND CARCINOGENESIS (1978) (13)
Familial retinoblastoma and ataxia telangiectasia human models for the study of DNA damage and repair (1980) (13)
Differential response of human and rodent cell lines to chemical inhibition of the repair of potentially lethal damage (1989) (13)
Sister chromatid exchange in painters recently exposed to solvents. (1989) (13)
A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation (2018) (13)
Studies of mutagenesis and neoplastic transformation by bivalent metal ions and ionizing radiation. (1988) (13)
Survival of synchronized V79 cells treated with X-rays and cordycepin. (1977) (12)
Effect of dose distribution on the induction of experimental lung cancer by alpha radiation. (1978) (12)
Lack of uncoupling of S phase and mitosis after irradiation in p53- human lymphoblast cell lines. (1997) (12)
Measurement of Polonium-210 in Human Blood (1966) (12)
Histologic Observations on the Pathogenesis of Lung Cancer in Hamsters Following Administration of Polonium-210 (1974) (12)
Radiation Sensitivity of Primary Fibroblasts from Hereditary Retinoblastoma Family Members and Some Apparently Normal Controls: Colony Formation Ability during Continuous Low-Dose-Rate Gamma Irradiation (2008) (12)
Evidence for a role for genomic instability in radiation-induced mutagenesis. (1997) (12)
Unexpected sensitivity to radiation of fibroblasts from unaffected parents of children with hereditary retinoblastoma (2002) (12)
Functional interplay between p53 and Δ133p53 in adaptive stress response (2019) (12)
High and Low Fluences of a -Particles Induce a G 1 Checkpoint in Human Diploid Fibroblasts 1 (2000) (12)
Identification of SV40 T-antigen mutants that alter T-antigen-induced chromosome damage in human fibroblasts. (1998) (12)
Differing patterns of cytotoxicity of the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in various human cell strains. (1985) (11)
Abnormal gene expression profiles in unaffected parents of patients with hereditary-type retinoblastoma. (2006) (11)
Effect of nonoxynol-9, a detergent with spermicidal activity, on malignant transformation in vitro. (1982) (11)
Repair of potentially lethal X-ray damage in fibroblasts derived from patients with hereditary and D-deletion retinoblastoma. (1985) (11)
Factors influencing exogenous nucleoside utilization in DNA synthesis by irradiated human cells. (1970) (11)
Mutagenic effects of restriction enzymes in Chinese hamster cells: evidence for high mutagenicity of Sau3AI at the hprt locus. (1993) (11)
Modulation of clonogenicity, growth, and radiosensitivity of three human epidermoid tumor cell lines by a fibroblastic environment. (1996) (11)
The influence of cellular proliferative history on the susceptibility to oncogenic transformation (1981) (11)
UXT, a novel MDMX-binding protein, promotes glycolysis by mitigating p53-mediated restriction of NF-κB activity (2015) (11)
Investigation of the cytotoxic effects of DNA damaging agents on neurofibromatosis cells. (1985) (11)
Mutation induction by 125iodoacetylproflavine, a DNA-intercalating agent, in human cells. (1990) (11)
Staining of glutaraldehyde fixed, glycol methacrylate embedded hamster lungs. (1974) (11)
Potentially lethal damage repair (PLDR) in X-irradiated cultures of a normal human diploid fibroblast cell strain. (1983) (11)
Differential p53, p21, mdm2 and Rb regulation in glioma cell lines that overexpress wild-type p53. (1998) (10)
Repair of DNA strand breaks in progeric fibroblasts and aging human diploid cells. (1975) (10)
Rapid recovery in human diploid fibroblasts. (1980) (10)
Enhancement of X-ray-induced transformation in C3H/10T1/2 cells by interferon. (1977) (10)
Relative responses of an X-ray-resistant hybrid cell-line and its parent line to X-irradiation, ultraviolet light, actinomycin D and cordycepin. (1977) (10)
Sister chromatid exchange in chronic ethylene oxide-exposed primates: unexpected effects of in vitro culture duration, incubation temperature, and serum supplementation. (1989) (10)
Environmental hazards. Ionizing radiation. (1966) (10)
Effects of estradiol concentration on levels of nuclear estrogen receptors in MCF-7 breast tumor cells. (1984) (10)
Survival of hereditary retinoblastoma human skin fibroblasts after treatment with DNA-damaging chemicals. (1982) (9)
ZBTB7A governs estrogen receptor alpha expression in breast cancer (2018) (9)
Respiratory tract tumors in hamsters induced by benzo(a)pyrene and 210Po alpha-radiation. (1974) (9)
DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16(ink4A) down-regulation. (2008) (9)
Interstitial deletion of chromosome 13 and associated congenital anomalies (1979) (9)
Proliferation kinetics of a human breast cancer line in vitro following treatment with 17beta-estradiol and 1-beta-D-arabinofuranosylcytosine. (1978) (9)
Evaluation of alpha radiation-induced respiratory carcinogenesis in Syrian hamsters: total dose and dose-rate. (1979) (9)
G2-Phase Chromosomal Radiosensitivity of Primary Fibroblasts from Hereditary Retinoblastoma Family Members and Some Apparently Normal Controls (2010) (9)
Characteristics of radiation-induced neoplastic transformation in vitro. (1986) (9)
Enhancement of radiation killing of cultured mammalian cells by cordycepin. (1978) (9)
Changes in frequencies of chromosomal aberrations and sister chromatid exchanges during confluent holding recovery in X-irradiated normal human diploid fibroblasts. (1985) (9)
Cellular Localization of Intratracheally Administered 210 PO in the Hamster Lung Using Autoradiography of Thin Sections from Plastic Embedded Tissue (1974) (9)
Adaptation of human diploid fibroblasts in vitro to serum from different sources. (1983) (9)
Survival of 60Co-irradiated herpes simplex virus in 15 human diploid fibroblast cell strains. (1982) (8)
In Vitro Studies of Fibroblasts from Patients with Retinoblastoma (1980) (8)
DEFECTIVE HOST-CELL REACTIVATION OF UV-IRRADIATED HERPES SIMPLEX VIRUS BY BLOOM'S SYNDROME SKIN FIBROBLASTS (1978) (8)
Differential sensitization of human tumor cells by ara-A to X irradiation and its relationship to inherent radioresponse. (1992) (8)
Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex (2016) (8)
Overexpression of p21 protein in radiation‐ transformed mouse 10T½ cell clones (2000) (8)
Characterization of rapid recovery from gamma-ray damage in plateau-phase human diploid fibroblasts. (1982) (8)
An in vitro investigation of genetic susceptibility to cancer in diploid fibroblasts from retinoblastoma patients. (1980) (8)
The molecular nature of mutants induced by X rays is altered by the presence of the radioprotector cysteamine. (1989) (8)
Further studies on the survival of non-proliferating human diploid fibroblasts irradiated with ultraviolet light. (1982) (8)
Fractionated radiation response of human cells in stationary and exponential phases of growth. (1973) (8)
Retinoic acid inhibits the fixation of initial transformational damage in X-irradiated Balb/3T3 mouse fibroblasts in vitro. (1989) (8)
Work in progress: radioprotection of human breast cancer cells by elevation of intracellular cyclic AMP. (1983) (7)
Lack of selective killing by steroids in normal and malignant cells (1980) (7)
Effect of aliphatic amides on oncogenic transformation, sister chromatid exchanges, and mutations induced by cyclopenta[cd]-pyrene and benzo[a]pyrene. (1986) (7)
Selection of mutant human cells whose progression into DNA synthesis is sensitive to UV irradiation. (1972) (7)
Molecular Events in Radiation Transformation (2001) (7)
Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo (2010) (7)
Exogenous lactate interferes with cell-cycle control in Balb/3T3 mouse fibroblasts. (1995) (7)
Experimental Respiratory Carcinogenesis: Interaction between Alpha Radiation and Benzo (a) pyrene in the Hamster (1974) (7)
Relative survival of hybrid X-ray-resistant, and normally sensitive mammalian cells exposed to X rays and protons under aerobic and hypoxic conditions. (1978) (7)
Genomic instability and radiation mutagenesis (1996) (7)
Effect of ionizing radiation on cell division in an amoeboid cell. (1968) (7)
Establishment and characteristics of a hamster lung adenocarcinoma in vivo and in vitro. (1975) (6)
Effect of restoration of retinoblastoma gene function on the radiosensitivity of cells of human tumor cell lines. (1994) (6)
Carcinogenicity of tobacco-smoke constituents. (1969) (6)
In vitro reversion of transformed phenotype in mouse C3H/10T1/2 cells. (1996) (6)
Heterogeneity in the clastogenic response to X-rays in lymphocytes from ataxia-telangiectasia heterozygotes and controls (1992) (6)
Sunscreen agents induce DNA repair activity in mouse embryo fibroblasts. (1984) (6)
Induction of mutations by bismuth-212 alpha particles at two genetic loci in human B-lymphoblasts. (1992) (6)
Actinomycin D suppresses radiation transformation in vitro. (1980) (6)
EFFECTS OF IONIZING RADIATION AND THEIR IMPORTANCE IN ANESTHESIOLOGY. (1964) (6)
[Nontargeted effects of ionizing radiation: implications for low-dose exposures]. (2007) (6)
Factors influencing the induction of lung cancer in hamsters by intratracheal administration of $sup 210$Po (1973) (6)
Alterations of mdm2 gene in x-ray transformed mouse 10t1/2 cell clones. (1995) (6)
Fibroblast radiosensitivity and intraocular fibrovascular proliferation following radiotherapy for bilateral retinoblastoma. (1986) (6)
Interactions between Radiation and Benzo(a)pyrene in an in vitro Model for Malignant Transformation (1974) (6)
Radiation-induced genomic instability and bystander effects: implications for radiation protection (2002) (6)
Effect of growth rate on phenotypic expression of 6-thioguanine resistance in human diploid fibroblasts. (1983) (6)
Radiation Therapy for Cancer of the Nasopharynx: Long-Term Follow-Up on 113 Adequately Treated Patients (1963) (6)
Spontaneous transformation to anchorage-independent growth of a xeroderma pigmentosum fibroblast cell strain. (1987) (6)
Respiratory system differences relevant to lung carcinogenesis between Syrian Hamsters and other species. (1979) (6)
Response to the Comments of Chadwick and Leenhouts (2000) (6)
Influence of genetic strain on the induction of lung cancer in hamsters by alpha radiation. (1973) (6)
Hemizygous fibroblast cell strains established from patients with BRCA1 or BRCA2 mutations demonstrate an increased rate of spontaneous mutations and increased radiosensitivity (2003) (6)
Spontaneous and induced levels of chromosomal aberration and sister-chromatid exchange in neurofibromatosis: no evidence of chromosomal hypersensitivity. (1992) (6)
Deposition and localization of polonium-210 intratracheally instilled in the hamster lung as determined by autoradiography of freeze-dried sections. (1977) (5)
Sequentially-induced responses define tumour cell radiosensitivity (2011) (5)
Coordination of the Ser2056 and Thr2609 Clusters of DNA-PKcs in Regulating Gamma Rays and Extremely Low Fluencies of Alpha-Particle Irradiation to G0/G1 Phase Cells (2017) (5)
RBE of the M.I.T. medical therapy neutron beam in monolayer cultures of hela cells. (1969) (5)
Strategies for the Prevention of Treatment-Induced Secondary Cancer (1991) (5)
Molecular structure of mutations at an autosomal locus in human cells: evidence for interallelic homologous recombination. (1991) (5)
Cytotoxicity of restriction enzyme-induced DNA strand breaks in radiosensitive and radioresistant human tumor cell lines. (1993) (5)
X-RAY SENSITIVITY OF FIBROBLASTS FROM PATIENTS WITH RETINOBLASTOMA AND WITH ABNORMALITIES OF CHROMOSOME 13 (1978) (5)
In vitro models of carcinogenesis: expression of recessive genes by chromosomal mutations. (1989) (5)
Repair of Potentially lethal Radiation (1973) (5)
Interrelationships among X‐ray‐induced anchorage independence, mutagenesis and chromosomal rearrangements in human diploid fibroblasts (1987) (5)
Normal repair of ultraviolet-induced DNA damage in a hypersensitive strain of fibroblasts from a patient with Gardner's syndrome. (1983) (5)
The impact of biology on risk assessment -- Workshop of the National Research Council`s board on radiation effects research. Meeting report (1997) (5)
An in vitro investigation of x-ray sensitivity in fibroblasts from patients with retinoblastoma. (1983) (5)
Mutagenic and chromosomal events in radiation transformation. (1985) (5)
Influence of isopropylvaleramide and allylisopropylacetamide on transformation of C3H/10T1/2 cells induced by benzo[a]pyrene derivatives. (1985) (4)
Characteristics and mechanisms of the bystander response in monolayer cell cultures exposed to very low fluences of alpha particles (2005) (4)
MDMX phosphorylation-dependent p53 downregulation contributes to an immunosuppressive tumor microenvironment (2020) (4)
Radiation Resistance in Lipovirus-Altered Human Cells (1965) (4)
Circulating antidiuretic hormone in the X-irradiated rat. (1968) (4)
Confluent holding leads to a transient enhancement in mutagenesis in UV-light-irradiated xeroderma pigmentosum, Gardner's syndrome and normal human diploid fibroblasts. (1985) (4)
Excision of ultraviolet damage and the effect of irradiation on DNA synthesis in a strain of Bloom's syndrome fibroblasts. (1981) (4)
Dissociated occurrence of single‐gene mutation and oncogenic transformation in C3H 10T½ cells exposed to ultraviolet light and caffeine (1982) (4)
P36 01 TP – COMPARISON OF MUTATION INDUCTION BY EXTERNAL AND INTERNAL RADIATION SOURCES IN SYNCHRONIZED CHINESE HAMSTER OVARY (CHO) CELLS (1991) (4)
Cross-sensitivity of certain xeroderma pigmentosum and cockayne syndrome fibroblast strains to both ionizing radiation and ultraviolet light (2004) (4)
Studies of ionizing radiation as a promoter of neoplastic transformation in vitro. (1988) (4)
Search for oncogene mutations in X-ray-transformed mouse 10T1/2 cells by denaturing gradient gel electrophoresis blotting. (1994) (4)
Modulation of survival and transformation during plateau-phase holding of UV-irradiated mouse cells. (1982) (4)
Mechanisms of malignant transformation of human diploid cells. (1985) (4)
Morphologic and histochemical characteristics of cell lines derived from hamster peripheral lung tumors. (1977) (4)
Fibroblast Radiosensitivity and Intraocular Fibrovascular Proliferation following Radiotherapy for Bilateral Retinoblastoma (1986) (4)
MDMX under stress: the MDMX-MDM2 complex as stress signals hub. (2016) (4)
Histochemistry of normal lungs and 210Po induced pulmonary tumors in hamsters. (1977) (4)
Oncogenic transformation in a mouse-embryo-derived cell line following acute and fractionated doses of x-radiation in vitro. Abstr. (1976) (3)
IN VITRO RADIOSENSITIVITY OF FIBROBLASTS DERIVED FROM PATIENTS WITH RETINOBLASTOMA AND ABNORMALITIES OF CHROMOSOME 13 (1983) (3)
Age-dependent modification by lactate of repair of potentially lethal damage in normal human diploid fibroblasts. (1989) (3)
Sensitization of noncycling human diploid cells to X-irradiation by pretreatment with 9-beta-D-arabinofuranosyladenine. (1989) (3)
Systemic absorption of polonium-210 inhaled in cigarette smoke. (1968) (3)
Recovery of mitomycin C-treated mouse 10T1/2 cells during confluent holding. (1988) (3)
54 The response of proliferating cell nuclear antigen (PCNA) to ionizing radiation in human lymphoblastoid cell lines with different p53 status (1997) (3)
Effects of serum-free defined medium on MCF-7 cell nuclear estrogen-receptor levels (1982) (3)
The Radiobiology of In Vitro Neoplastic Transformation (1986) (3)
Transmission of damage signals from irradiated to nonirradiated cells (2002) (3)
Cell cycle deregulation and xeroderma pigmentosum group C cell transformation. (2002) (3)
Relationship of DNA repair and chromosome aberrations to potentially lethal damage repair in X-irradiated mammalian cells. (1980) (3)
Combination hormonal, chemotherapy and radiotherapy in vitro: implications for therapy in vivo. (1979) (3)
Effect of Diagnostic Radiation Upon the Human Foetus: Follow-up Study of 152 Children Exposed to Irradiation During the First 4 Months of Foetal Life Due to X-Ray Examination of the Maternal Abdomen (1969) (3)
THE EFFECT OF DNA DAMAGE ON THE INDUCTION OF SIMIAN VIRUS 40 (SV40) IN TRANSFORMED HAMSTER CELLS (1978) (3)
Radiosensitivity of human hematopoietic cell lines of distinguishable stages of biochemical and physiological differentiation (1979) (3)
Role and Regulation of p 53 during an Ultraviolet Radiation-induced G 1 Cell Cycle Arrest 1 (2000) (3)
EFFECTS OF FLUENCE FRACTIONATION ON UV‐INDUCED MALIGNANT TRANSFORMATION AND CELL KILLING IN NON‐CYCLING PLATEAU PHASE MOUSE CELLS (1982) (2)
RFLP mapping of thymidine kinase mutants places D17S4 proximal to the human TK1 locus (1991) (2)
Bystander Effects of Ionizing Radiation (2017) (2)
Oncogenic Cell Transformation in Vitro (1992) (2)
A technique for developing established cell lines from human osteosarcomas (1976) (2)
Role of Energy Distribution in DNA on the Mutagenic Effects of Internal Emitters (1991) (2)
Identification of SV40 T‐antigen mutants that alter T‐antigen‐induced chromosome damage in human fibroblasts. Cytometry 31:242–250, 1998 (1998) (2)
Transformation of Human Diploid Fibroblasts by Radiation and Oncogenes (1991) (2)
SV40LT highly mutates and immortalizes two fibroblast strains from patients with Wilms' tumor. (1999) (2)
Exogenous lactate modifies the repair of potentially lethal damage in three human tumor cell lines irradiated in vitro. (1990) (2)
Comprehensive progress report (1980) (2)
Differential regulation of cdk2 and cyclin D1 in irradiated human glioma cells. (1997) (2)
Loss of Normal G 1 Checkpoint Control Is an Early Step in Carcinogenesis , Independent of p 53 Status 1 (1999) (2)
Effects of 12-0-tetradecanoyl-phorbol-13-acetate (tpa) and low cell density of x-ray transformation of c3h 10t1/2 cells. Abstr. (1980) (1)
ONCOGENE ACTIVATION DURING RADIATION TRANSFORMATION IN VITRO (1992) (1)
Experimental Radiation-Induced Carcinogenesis (2003) (1)
RBE and OER of the heavy ionizing particles released during 10beta-neutron capture therapy. (1968) (1)
Disruption of NBS1 gene leads to early embryonic lethality in homozygous null mice and induces specific cancer in heterozygous mice (2001) (1)
Lung cancer induced in hamsters by low doses of alpha radiation from $sup 210$Po (1975) (1)
Repair of potentially lethal radiation damage in plateau phase cultures of mammalian cells (1973) (1)
Complex interactions of caffeine and its structural analogs with ultraviolet light in cell killing. (1981) (1)
The MDM2/MDMX/p53 axis in the adaptive stress response (2020) (1)
Selective protection of cultured human cells from the toxic effects of ultraviolet light by proflavine pretreatment. (1977) (1)
Development of Radiation Injury (2003) (1)
Altered DNA Metabolism in Aged and Progeric Fibroblasts (1975) (1)
Low Dose Radiation Effects in Human Cells (1989) (1)
General discussion: molecular mechanisms of radiation carcinogenesis and their implications in radiation policy (2002) (1)
Radiation-Induced Chromosome Damage in Man T. Ishihara, M. S. Sasaki, Eds. New York, Alan R. Liss, Inc., 1984, 650 pp, $98.00 (1984) (1)
Advances in Brief p 53 Is Involved in But Not Required for Ionizing Radiation-induced Caspase-3 Activation and Apoptosis in Human Lymphoblast Cell Lines 1 (2006) (1)
Malignant transformation and dna damage by povidone-iodine in cultured mammalian cells. Abstr. (1981) (1)
Toxicity and mutual interactions of cadmium and zinc ions in normal and carcinogen-transformed mouse cells (1986) (0)
6 – DNA REPAIR IN CULTURED MAMMALIAN CELLS (1977) (0)
Proliferation Kinetics of a Human Breast Cancer Line in Vitro following Treatment with 17/3-E stradici and 1-ÃŸ-D-Arabinofuranosylcytosine1 (2006) (0)
SYSTEMIC ABSORPTION OF $sup 210$Po INHALED IN CIGARETTE SMOKE. (1969) (0)
Mechanisms of Radiation Transformation (1986) (0)
Mutagenic effects of restriction enzymes in Chinese hamstcr cells (1994) (0)
P26 25 WP – SPONTANEOUS AND RADIATION-INDUCED TRANSFORMATION IN VITRO OF EPITHELIOID CELLS FROM A PATIENT WITH SPORADIC RETINOBLASTOMA (1991) (0)
Advances in Brief Persistent Genetic Instability in Cancer Cells Induced by Non-DNA-damaging Stress Exposures 1 (2001) (0)
P04 04 SP – DETECTION OF RADIATION-INDUCED GENETIC REARRANGEMENTS AT VNTR LOCI IN THE HUMAN GENOME (1991) (0)
Potentially lethal damage repair may be a major determinate of local radiocurability (1979) (0)
Effect of Time and Duration of Exposure to 12-O-Tetradecanoylphorbol I 3-acetate on X-RayTransformationof C3H 1OT% Cellsâ€(cid:157) (2006) (0)
S09 02 MA – ONCOGENE ACTIVATION DURING RADIATON TRANSFORMATION IN VITRO (1991) (0)
P14 09 MP – CHARACTERIZATION OF DELAYED REPRODUCTIVE DEATH IN X-IRRADIATED AND EMS-TREATED MAMMALIAN CELLS (1991) (0)
Use of Repair-Deficient Mammalian Cells for the Identification of Carcinogens (1983) (0)
Effects of Ionizing Radiation on Mammalian Cells (2011) (0)
Radiation transformation in vitro in relation to dna damage and repair processes. Abstr. (1978) (0)
Importance of repair of potentially lethal damage in assays of cytotoxic agents. (1982) (0)
COMMENTS ON REPORTS: POLONIUM-210 IN CIGARETTE SMOKERS (1964) (0)
Influence of growth phase and cultural conditions on survival of irradiated mammalian cells in vitro (1973) (0)
Effect of 17 beta estradiol (17BE) on the repair of potentially lethal X-ray damage in human breast cancer cell (1980) (0)
Radiosensitivities of Ten Apparently Normal Human Diploid Fibroblast Cell Killing, G2-Phase Chromosomal Aberrations, and Cell Cycle Delay1 (2006) (0)
Metabolic alterations with senescence of human cells. Effect of ionizing radiation. (1965) (0)
Functional interplay between p53 and Δ133p53 in adaptive stress response (2019) (0)
in Human Diploid Fibroblasts Checkpoint 1-Particles Induce a G α High and Low Fluences of Updated (2000) (0)
Non-Targeted Effects of Ionizing Radiation: Implications for Radiation Protection (2020) (0)
P04 30 SP – APPLICATION OF NOVEL METHOD OF DENATURING GRADIENT GEL BLOTS (DGGB) TO THE ANALYSIS OF p53 IN X-RAY TRANSFORMED MOUSE 10T1/2 CELL LINES (1991) (0)
Effect of LET and microdistribution of radiation on the transformation in vitro and in vivo. Comprehensive progress report (1983) (0)
Regulation by Ionizing Radiation of CDC2, Cyclin A, Cyclin B, Thymidine Kinase, Topoisomerase Iki, and RAD5I Expression in Normal Human Diploid Fibroblasts (1998) (0)
Response to the Letter by Colin Seymour and Carmel Mothersill. (1999) (0)
Polonium-210 in lungs and soft tissues of cigarette smokers. (Abstract only) (1964) (0)
RESPIRATORY CARCINOGENESIS IN HAMSTERS INDUCED BY $sup 210$Po ALPHA RADIATION AND BENZO[a]PYRENE. (1971) (0)
Recovery from fractionated radiation in plateau phase human melanoma cells (1981) (0)
Symposium: Radiation Litigation: Past, Present, Future: Introduction (2010) (0)
P36 04 TP – MOLECULAR CHARACTERIZATION OF HPRT AND TK MUTANTS INDUCED BY ALPHA PARTICLES (1991) (0)
Protease inhibitor suppresses plasminogen activator activity in transformable mouse embryo fibroblasts. Abstr. (1980) (0)
P04 01 SP – MUTATIONAL SPECTRA INDUCED BY X-RAYS UNDER OXIC AND HYPOXIC CONDITIONS (1991) (0)
Malignant Transformation by Ultraviolet and Ionizing Radiations (1991) (0)
DMA Damage Induced in Human Diploid Cells by Decay of Incorporated Radionuclides1 (2006) (0)
No induction of interchromosomal recombination by X-ray on thymidine kinase gene in human lymphoblast TK6 and its derivative cells (1994) (0)
Effects of Low-Dose Alpha-Particle Irradiation in Human Cells: The Role of Induced Genes and the Bystander Effect. Final Technical Report (9/15/1998-5/31/2005) (2013) (0)
The relation of potentially lethal damage (pld) repair to chromosome aberration production, sister chromatid exchanges, and dna repair after x-irradiation. Abstr. (1978) (0)
Methotrexate penetration of human osteogenic sarcoma multitumor cell spheroids: an in vitro model for micrometastases and adjuvant chemotherapy (1979) (0)
Assaying genetic recombination between alleles at the endogenous human thymidine kinase locus (1990) (0)
Morphological alteration of X-ray induced partially transformed human cells by transfection with a small c-myc DNA sequence. (2000) (0)
Alteration of cell cycle parameters by 17 beta estradiol (17 be) in a human breast carcinoma line In vitro: implications for combination therapy in vivo (1978) (0)
Transformation of mouse embryo fibroblasts (10t1/2) with incorporated radioisotopes. Abstr. (1978) (0)
In vitro radiosensitivity of fibroblasts from patients with familial and sporadic retinoblastoma: A naturally occurring model for the study of mutagenesis and carcinogenesis (1978) (0)
Recent articles in ageing research. (1973) (0)
Figure 19-3, [Schematic of radiation-induced mutagenesis. Open...]. (2003) (0)
O X.1 Radiation-induced genomic instability: Delayed mutagenic and cytogenetic effects (1997) (0)
Advances in Brief Relationship between Radiation-induced G, Phase Arrest and p53 Function in Human Tumor Cells1 (2006) (0)
Status p 53 Carcinogenesis , Independent of Checkpoint Control Is an Early Step in 1 Loss of Normal G Updated (1999) (0)
Role of tumor suppressor genes in determining radiation‐induced G1 arrest and transformation in human cells (1995) (0)
Effect of LET and microdistribution of radiation on the transformation in vitro and in vivo (1983) (0)

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