Vadim N. Gladyshev
#81,337
Most Influential Person Now
Researcher
Vadim N. Gladyshev's AcademicInfluence.com Rankings
Vadim N. Gladyshevbiology Degrees
Biology
#4540
World Rank
#6759
Historical Rank
Biochemistry
#565
World Rank
#655
Historical Rank
Download Badge
Biology
Vadim N. Gladyshev's Degrees
- PhD Biochemistry Moscow State University
- Doctorate Medicine Moscow State University
Why Is Vadim N. Gladyshev Influential?
(Suggest an Edit or Addition)According to Wikipedia, Vadim N. Gladyshev is a professor of medicine at Brigham and Women's Hospital, Harvard Medical School, who specializes in antioxidant biology. He is known for his characterization of the human selenoproteome. He is also known for his work on the effects of aging in humans. He has conducted studies on whether organisms can acquire cellular damage from their food; the role selenium plays as a micro-nutrient with significant health benefits; In 2013 he won the NIH Pioneer Award.
Vadim N. Gladyshev's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions (2007) (2504)
- Characterization of Mammalian Selenoproteomes (2003) (2047)
- Selenoproteins: molecular pathways and physiological roles. (2014) (807)
- How Selenium Has Altered Our Understanding of the Genetic Code (2002) (633)
- Selenium and selenocysteine: roles in cancer, health, and development. (2014) (521)
- Genome sequencing reveals insights into physiology and longevity of the naked mole rat (2011) (511)
- Crystal Structure of Formate Dehydrogenase H: Catalysis Involving Mo, Molybdopterin, Selenocysteine, and an Fe4S4 Cluster (1997) (463)
- Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. (1996) (450)
- Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits (2015) (414)
- DNA methylation aging clocks: challenges and recommendations (2019) (393)
- Redox Regulation of Cell Signaling by Selenocysteine in Mammalian Thioredoxin Reductases* (1999) (321)
- Eukaryotic selenoproteins and selenoproteomes. (2009) (305)
- Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems (2001) (287)
- Cysteine function governs its conservation and degeneration and restricts its utilization on protein surfaces. (2010) (285)
- Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. (2003) (285)
- Biosynthesis of Selenocysteine on Its tRNA in Eukaryotes (2006) (275)
- Thioredoxin Reductase 1 Deficiency Reverses Tumor Phenotype and Tumorigenicity of Lung Carcinoma Cells* (2006) (274)
- Reprogramming to recover youthful epigenetic information and restore vision (2020) (273)
- Niche of harmful alga Aureococcus anophagefferens revealed through ecogenomics (2011) (265)
- Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress (2012) (260)
- Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase (2002) (259)
- Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii (2002) (258)
- Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions. (2017) (249)
- Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization (2009) (247)
- Translation inhibitors cause abnormalities in ribosome profiling experiments (2014) (234)
- New Mammalian Selenocysteine-containing Proteins Identified with an Algorithm That Searches for Selenocysteine Insertion Sequence Elements* (1999) (227)
- Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii (2013) (226)
- Identification and Characterization of a New Mammalian Glutaredoxin (Thioltransferase), Grx2* (2001) (218)
- The prokaryotic selenoproteome (2004) (217)
- Analysis and Functional Prediction of Reactive Cysteine Residues* (2011) (217)
- LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation. (2019) (214)
- Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes (2012) (212)
- Structural analysis of cysteine S-nitrosylation: a modified acid-based motif and the emerging role of trans-nitrosylation. (2010) (203)
- The free radical theory of aging is dead. Long live the damage theory! (2014) (199)
- MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. (2013) (194)
- Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals. (2007) (189)
- SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. (2007) (186)
- Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. (2004) (186)
- Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life (2007) (185)
- Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino acid status (2014) (184)
- Hydrogen Peroxide Probes Directed to Different Cellular Compartments (2011) (182)
- NMR Structures of the Selenoproteins Sep15 and SelM Reveal Redox Activity of a New Thioredoxin-like Family* (2006) (178)
- Selenoprotein Gene Nomenclature* (2016) (177)
- A New Human Selenium-containing Protein (1998) (176)
- Specific Excision of the Selenocysteine tRNA[Ser]Sec (Trsp) Gene in Mouse Liver Demonstrates an Essential Role of Selenoproteins in Liver Function* (2004) (173)
- Mammalian Selenoprotein Thioredoxin-glutathione Reductase (2005) (172)
- High-Throughput Identification of Catalytic Redox-Active Cysteine Residues (2007) (171)
- Functions and evolution of selenoprotein methionine sulfoxide reductases. (2009) (171)
- Different Catalytic Mechanisms in Mammalian Selenocysteine- and Cysteine-Containing Methionine-R-Sulfoxide Reductases (2005) (169)
- Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase. (2004) (169)
- Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis (2006) (168)
- Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins. (2010) (166)
- Comparative Genomic Analyses of Copper Transporters and Cuproproteomes Reveal Evolutionary Dynamics of Copper Utilization and Its Link to Oxygen (2008) (165)
- Novel metabolism in Chlamydomonas through the lens of genomics. (2007) (165)
- Comparative genetics of longevity and cancer: insights from long-lived rodents (2014) (165)
- Selenocysteine-containing proteins in mammals. (1999) (165)
- Structure-Expression Relationships of the 15-kDa Selenoprotein Gene (2000) (163)
- SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species (2019) (162)
- Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration (2016) (162)
- Selenocysteine incorporation machinery and the role of selenoproteins in development and health. (2006) (161)
- Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice. (2011) (160)
- Molybdoproteomes and evolution of molybdenum utilization. (2008) (157)
- Mechanisms of cancer resistance in long-lived mammals (2018) (157)
- Association between the 15-kDa Selenoprotein and UDP-glucose:Glycoprotein Glucosyltransferase in the Endoplasmic Reticulum of Mammalian Cells* (2001) (157)
- Reaction Mechanism, Evolutionary Analysis, and Role of Zinc in Drosophila Methionine-R-sulfoxide Reductase* (2002) (156)
- Dietary selenium affects host selenoproteome expression by influencing the gut microbiota (2011) (154)
- Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes (2016) (153)
- Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes. (2014) (150)
- Mammalian Selenoprotein in Which Selenocysteine (Sec) Incorporation Is Supported by a New Form of Sec Insertion Sequence Element (2002) (149)
- Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox active cysteine residues (2006) (148)
- Identity and functions of CxxC-derived motifs. (2003) (145)
- Selenoproteins Mediate T Cell Immunity through an Antioxidant Mechanism* (2008) (140)
- Comparative Analysis of Selenocysteine Machinery and Selenoproteome Gene Expression in Mouse Brain Identifies Neurons as Key Functional Sites of Selenium in Mammals* (2008) (139)
- Targeting Thioredoxin Reductase 1 Reduction in Cancer Cells Inhibits Self-Sufficient Growth and DNA Replication (2007) (136)
- Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene. (2001) (135)
- Selenocysteine in thiol/disulfide-like exchange reactions. (2013) (135)
- Reduced reliance on the trace element selenium during evolution of mammals (2008) (133)
- Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide (2011) (133)
- A comparative genomics multitool for scientific discovery and conservation (2020) (133)
- Gene expression defines natural changes in mammalian lifespan (2015) (127)
- Biosynthesis of selenocysteine, the 21st amino acid in the genetic code, and a novel pathway for cysteine biosynthesis. (2011) (126)
- Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells. (1998) (126)
- Selective Rescue of Selenoprotein Expression in Mice Lacking a Highly Specialized Methyl Group in Selenocysteine tRNA* (2005) (126)
- Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues (2000) (123)
- DNA repair in species with extreme lifespan differences (2015) (118)
- General Trends in Trace Element Utilization Revealed by Comparative Genomic Analyses of Co, Cu, Mo, Ni, and Se* (2009) (118)
- Genetic Code Supports Targeted Insertion of Two Amino Acids by One Codon (2009) (117)
- The Sep15 protein family: Roles in disulfide bond formation and quality control in the endoplasmic reticulum (2007) (117)
- Pyrrolysine and Selenocysteine Use Dissimilar Decoding Strategies* (2005) (117)
- The Outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) reveals the need for better understanding of selenium biology. (2009) (116)
- Ribonuclease selection for ribosome profiling (2016) (115)
- Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease. (2010) (114)
- Selenoproteins that function in cancer prevention and promotion. (2009) (114)
- Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. (2003) (113)
- Selective Inhibition of Selenocysteine tRNA Maturation and Selenoprotein Synthesis in Transgenic Mice Expressing Isopentenyladenosine-Deficient Selenocysteine tRNA (2001) (113)
- Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice (2005) (112)
- Comparative genomics of trace elements: emerging dynamic view of trace element utilization and function. (2009) (112)
- The biological significance of methionine sulfoxide stereochemistry. (2011) (111)
- Selenoprotein H Is a Nucleolar Thioredoxin-like Protein with a Unique Expression Pattern* (2007) (111)
- Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies. (2011) (110)
- Selenoprotein K Binds Multiprotein Complexes and Is Involved in the Regulation of Endoplasmic Reticulum Homeostasis* (2011) (110)
- An algorithm for identification of bacterial selenocysteine insertion sequence elements and selenoprotein genes (2005) (110)
- Role of reactive oxygen species-mediated signaling in aging. (2013) (108)
- MsrB1 (Methionine-R-sulfoxide Reductase 1) Knock-out Mice (2009) (107)
- Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer. (1998) (104)
- Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution (2004) (103)
- Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism. (2005) (103)
- Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family. (2005) (103)
- Role of selenium-containing proteins in T-cell and macrophage function (2010) (102)
- Selective Removal of the Selenocysteine tRNA[Ser]Sec Gene (Trsp) in Mouse Mammary Epithelium (2003) (102)
- Sep15, a thioredoxin-like selenoprotein, is involved in the unfolded protein response and differentially regulated by adaptive and acute ER stresses. (2009) (102)
- Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks. (2015) (100)
- Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells (2018) (100)
- Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase. (1999) (99)
- A whole lifespan mouse multi-tissue DNA methylation clock (2018) (99)
- Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity. (2015) (98)
- Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74. (2011) (97)
- Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein (2006) (94)
- Evidence for Direct Roles of Two Additional Factors, SECp43 and Soluble Liver Antigen, in the Selenoprotein Synthesis Machinery* (2005) (93)
- Selenium Metabolism in Drosophila (2001) (92)
- Characterization of Alternative Cytosolic Forms and Cellular Targets of Mouse Mitochondrial Thioredoxin Reductase* (2006) (92)
- Platyhelminth Mitochondrial and Cytosolic Redox Homeostasis Is Controlled by a Single Thioredoxin Glutathione Reductase and Dependent on Selenium and Glutathione* (2008) (92)
- Evolution of selenium utilization traits (2005) (91)
- Functional diversity of cysteine residues in proteins and unique features of catalytic redox-active cysteines in thiol oxidoreductases. (2008) (91)
- The microbial selenoproteome of the Sargasso Sea (2005) (91)
- Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery (2010) (90)
- Roles of the 15-kDa Selenoprotein (Sep15) in Redox Homeostasis and Cataract Development Revealed by the Analysis of Sep 15 Knockout Mice* (2011) (90)
- Universal DNA Methylation Age Across Mammalian Tissues (2021) (89)
- Comprehensive variation discovery and recovery of missing sequence in the pig genome using multiple de novo assemblies. (2017) (89)
- Deficiency in the 15-kDa Selenoprotein Inhibits Tumorigenicity and Metastasis of Colon Cancer Cells (2010) (89)
- INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform (2014) (89)
- Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase. (2005) (87)
- Understanding selenoprotein function and regulation through the use of rodent models. (2012) (86)
- The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan. (2013) (85)
- Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum (2016) (85)
- Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif (2007) (85)
- Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression (2009) (84)
- Selenocysteine-containing thioredoxin reductase in C. elegans. (1999) (84)
- CxxS: Fold‐independent redox motif revealed by genome‐wide searches for thiol/disulfide oxidoreductase function (2002) (84)
- Protein synthesis and quality control in aging (2018) (84)
- Role of structural and functional elements of mouse methionine-S-sulfoxide reductase in its subcellular distribution. (2005) (83)
- Nematode selenoproteome: the use of the selenocysteine insertion system to decode one codon in an animal genome? (2005) (82)
- Evolution of selenocysteine-containing proteins: significance of identification and functional characterization of selenoproteins. (2001) (82)
- Heterogeneity within Animal Thioredoxin Reductases (2001) (82)
- Molecular signatures of longevity: Insights from cross-species comparative studies. (2017) (81)
- Catalytic advantages provided by selenocysteine in methionine-S-sulfoxide reductases. (2006) (81)
- Selenoproteinless animals: Selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis (2007) (80)
- Trends in Selenium Utilization in Marine Microbial World Revealed through the Analysis of the Global Ocean Sampling (GOS) Project (2008) (79)
- Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development (2010) (78)
- Functional Analysis of Free Methionine-R-sulfoxide Reductase from Saccharomyces cerevisiae* (2009) (78)
- A Novel Cysteine-rich Domain of Sep15 Mediates the Interaction with UDP-glucose:Glycoprotein Glucosyltransferase* (2005) (77)
- Identification and Application of Gene Expression Signatures Associated with Lifespan Extension. (2019) (77)
- COVID-19 is an emergent disease of aging (2020) (77)
- Coordination of selenium to molybdenum in formate dehydrogenase H from Escherichia coli. (1994) (77)
- Knocking out multi-gene redundancies via cycles of sexual assortment and fluorescence selection (2010) (76)
- Lifespan Extension Conferred by Endoplasmic Reticulum Secretory Pathway Deficiency Requires Induction of the Unfolded Protein Response (2014) (75)
- NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension (2018) (75)
- SECISearch3 and Seblastian: new tools for prediction of SECIS elements and selenoproteins (2013) (75)
- Population genomics of finless porpoises reveal an incipient cetacean species adapted to freshwater (2018) (74)
- Semisynthesis and characterization of mammalian thioredoxin reductase. (2006) (74)
- Analysis of cancer genomes reveals basic features of human aging and its role in cancer development (2016) (74)
- Solution Structure of Selenoprotein W and NMR Analysis of Its Interaction with 14-3-3 Proteins* (2007) (73)
- The Plasmodium selenoproteome (2006) (73)
- X-ray fluorescence microscopy reveals the role of selenium in spermatogenesis. (2009) (73)
- Methionine Sulfoxide Reductases Preferentially Reduce Unfolded Oxidized Proteins and Protect Cells from Oxidative Protein Unfolding* (2012) (71)
- Nicotinic acid hydroxylase from Clostridium barkeri: electron paramagnetic resonance studies show that selenium is coordinated with molybdenum in the catalytically active selenium-dependent enzyme. (1994) (69)
- Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning (2020) (68)
- Identification of a Novel System for Boron Transport: Atr1 Is a Main Boron Exporter in Yeast (2009) (66)
- High content of proteins containing 21st and 22nd amino acids, selenocysteine and pyrrolysine, in a symbiotic deltaproteobacterium of gutless worm Olavius algarvensis (2007) (65)
- A conserved cis-proline precludes metal binding by the active site thiolates in members of the thioredoxin family of proteins. (2007) (65)
- A highly efficient form of the selenocysteine insertion sequence element in protozoan parasites and its use in mammalian cells (2007) (65)
- Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets. (2010) (64)
- Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity (2018) (64)
- Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1. (2015) (63)
- Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase. (2004) (62)
- Mitochondrial thioltransferase (glutaredoxin 2) has GSH‐dependent and thioredoxin reductase‐dependent peroxidase activities in vitro and in lens epithelial cells (2006) (62)
- Identification of trace element-containing proteins in genomic databases. (2004) (62)
- AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation (2018) (61)
- Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites. (2013) (60)
- Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice. (2010) (59)
- Comparative Genomics and Evolution of Molybdenum Utilization. (2011) (58)
- Dual functions of codons in the genetic code (2010) (58)
- Selective Restoration of the Selenoprotein Population in a Mouse Hepatocyte Selenoproteinless Background with Different Mutant Selenocysteine tRNAs Lacking Um34* (2007) (58)
- Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities (2020) (58)
- Human microbiome aging clocks based on deep learning and tandem of permutation feature importance and accumulated local effects (2018) (58)
- The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal (2014) (57)
- Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis. (2012) (57)
- Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence (2018) (57)
- Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity (2016) (56)
- Recode-2: new design, new search tools, and many more genes (2009) (56)
- SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements (2008) (55)
- Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases (2006) (55)
- Regulated methionine oxidation by monooxygenases. (2017) (55)
- Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human (2015) (55)
- Alternative splicing involving the thioredoxin reductase module in mammals: a glutaredoxin-containing thioredoxin reductase 1. (2004) (55)
- COVID‐19 is an emergent disease of aging (2020) (55)
- Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation (2014) (54)
- Properties of the selenium- and molybdenum-containing nicotinic acid hydroxylase from Clostridium barkeri. (1996) (54)
- Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction (2018) (53)
- Genome-Wide RNAi Ionomics Screen Reveals New Genes and Regulation of Human Trace Element Metabolism (2014) (53)
- In silico identification of genes involved in selenium metabolism: evidence for a third selenium utilization trait (2008) (53)
- Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae (2015) (52)
- Structure and Catalytic Mechanism of Eukaryotic Selenocysteine Synthase* (2008) (52)
- Genome-wide association study of selenium concentrations. (2015) (51)
- Mammalian selenoprotein gene signature: identification and functional analysis of selenoprotein genes using bioinformatics methods. (2002) (51)
- Translation fidelity coevolves with longevity (2017) (51)
- Position dependent termination and widespread obligatory frameshifting in Euplotes translation (2016) (50)
- Mammals Reduce Methionine-S-sulfoxide with MsrA and Are Unable to Reduce Methionine-R-sulfoxide, and This Function Can Be Restored with a Yeast Reductase* (2008) (50)
- Population Genomics Reveals Low Genetic Diversity and Adaptation to Hypoxia in Snub-Nosed Monkeys. (2016) (50)
- Non-enzymatic molecular damage as a prototypic driver of aging (2017) (50)
- Characterization of Crystalline Formate Dehydrogenase H from Escherichia coli (1996) (49)
- Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells. (2009) (49)
- Boron Stress Activates the General Amino Acid Control Mechanism and Inhibits Protein Synthesis (2011) (49)
- Redox biology: computational approaches to the investigation of functional cysteine residues. (2011) (49)
- Mouse Models Targeting Selenocysteine tRNA Expression for Elucidating the Role of Selenoproteins in Health and Development (2009) (48)
- Selenoprotein S is involved in maintenance and transport of multiprotein complexes. (2014) (48)
- Comparative Genomics of Trace Element Dependence in Biology* (2011) (48)
- Characterization of methionine oxidation and methionine sulfoxide reduction using methionine-rich cysteine-free proteins (2012) (48)
- Selenoproteins and Selenoproteomes (2006) (47)
- SELENOPROTEINS, SELENOPROTEIN mRNA EXPRESSION, FERTILITY, AND MORTALITY* (2001) (47)
- CUG Start Codon Generates Thioredoxin/Glutathione Reductase Isoforms in Mouse Testes*♦ (2009) (47)
- Non‐animal origin of animal thioredoxin reductases: Implications for selenocysteine evolution and evolution of protein function through carboxy‐terminal extensions (2003) (46)
- Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism. (2008) (46)
- Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors (2015) (46)
- Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo (2017) (46)
- Regulation of Selenocysteine Content of Human Selenoprotein P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine (2015) (45)
- Selenium Deficiency Is Associated with Pro-longevity Mechanisms (2019) (45)
- Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. (2015) (44)
- Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms. (2008) (44)
- Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework (2020) (44)
- Multifaceted deregulation of gene expression and protein synthesis with age (2020) (44)
- Knockout of the 15 kDa Selenoprotein Protects against Chemically-Induced Aberrant Crypt Formation in Mice (2012) (43)
- Selenoproteins in colon cancer (2018) (43)
- Characterization of Mammalian Selenoprotein O: A Redox-Active Mitochondrial Protein (2014) (43)
- Inhibition of Cellular Methyltransferases Promotes Endothelial Cell Activation by Suppressing Glutathione Peroxidase 1 Protein Expression* (2014) (43)
- On the cause of aging and control of lifespan (2012) (43)
- New Developments in Selenium Biochemistry: Selenocysteine Biosynthesis in Eukaryotes and Archaea (2007) (43)
- Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization (2015) (42)
- A Disease or Not a Disease? Aging As a Pathology. (2016) (41)
- Comparative transcriptomics of 5 high-altitude vertebrates and their low-altitude relatives (2017) (41)
- Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells (2009) (41)
- Profiling epigenetic age in single cells (2021) (41)
- Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins (2018) (41)
- Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins (2015) (41)
- High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3. (2012) (41)
- The selenoproteome of Clostridium sp. OhILAs: Characterization of anaerobic bacterial selenoprotein methionine sulfoxide reductase A (2009) (40)
- The mutual sparing effects of selenium and vitamin E in animal nutrition may be further explained by the discovery that mammalian thioredoxin reductase is a selenoenzyme. (1995) (39)
- Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis (2016) (39)
- A functional link between housekeeping selenoproteins and phase II enzymes. (2008) (39)
- Gene expression signatures of human cell and tissue longevity (2016) (39)
- Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging (2021) (39)
- SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes (2006) (39)
- The conundrum of human immune system “senescence” (2020) (38)
- Selenoprotein expression is essential in endothelial cell development and cardiac muscle function (2007) (37)
- Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems (2016) (37)
- The 15kDa Selenoprotein and Thioredoxin Reductase 1 Promote Colon Cancer by Different Pathways (2015) (37)
- The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice. (2009) (37)
- Functional characterization of alternatively spliced human SECISBP2 transcript variants (2008) (36)
- Recharging oxidative protein repair: Catalysis by methionine sulfoxide reductases towards their amino acid, protein, and model substrates (2012) (36)
- Identification of Thioredoxin Glutathione Reductase Inhibitors That Kill Cestode and Trematode Parasites (2012) (36)
- Identification and characterization of Fep15, a new selenocysteine-containing member of the Sep15 protein family. (2006) (36)
- Thioredoxin and glutathione systems differ in parasitic and free-living platyhelminths (2010) (35)
- Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression (2009) (35)
- Linked Thioredoxin-Glutathione Systems in Platyhelminth Parasites (2010) (34)
- Loss of epigenetic information as a cause of mammalian aging (2023) (34)
- Characterization of surface-exposed reactive cysteine residues in Saccharomyces cerevisiae. (2010) (34)
- SelenoDB 2.0: annotation of selenoprotein genes in animals and their genetic diversity in humans (2013) (33)
- N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance (2020) (33)
- Reduced Utilization of Selenium by Naked Mole Rats Due to a Specific Defect in GPx1 Expression* (2011) (33)
- 4.14 – Biosynthesis of Selenocysteine and its Incorporation into Proteins as the 21st Amino Acid (1999) (33)
- The central role of selenium in the biochemistry and ecology of the harmful pelagophyte, Aureococcus anophagefferens (2013) (32)
- Methionine Sulfoxide Reduction and the Aging Process (2007) (32)
- Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size. (2014) (31)
- Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals (2019) (31)
- HIF-Independent Regulation of Thioredoxin Reductase 1 Contributes to the High Levels of Reactive Oxygen Species Induced by Hypoxia (2012) (31)
- Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality. (2019) (31)
- Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging (2009) (30)
- Inhibition of selenocysteine tRNA[Ser]Sec aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA (2011) (30)
- Utilization of selenocysteine in early-branching fungal phyla (2019) (30)
- Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals. (2016) (30)
- UGA codon position-dependent incorporation of selenocysteine into mammalian selenoproteins (2013) (30)
- Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity (2018) (29)
- A Structure-Based Approach for Detection of Thiol Oxidoreductases and Their Catalytic Redox-Active Cysteine Residues (2009) (29)
- Chlamydomonas reinhardtii selenocysteine tRNA[Ser]Sec. (2003) (29)
- Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway. (2015) (29)
- Is there a twenty third amino acid in the genetic code? (2006) (28)
- Convergent evolution of marine mammals is associated with distinct substitutions in common genes (2015) (28)
- Comparative genomics of thiol oxidoreductases reveals widespread and essential functions of thiol-based redox control of cellular processes. (2012) (28)
- Insights into Function, Catalytic Mechanism, and Fold Evolution of Selenoprotein Methionine Sulfoxide Reductase B1 through Structural Analysis* (2010) (28)
- Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast. (2010) (28)
- Analyses of Fruit Flies That Do Not Express Selenoproteins or Express the Mouse Selenoprotein, Methionine Sulfoxide Reductase B1, Reveal a Role of Selenoproteins in Stress Resistance* (2011) (28)
- Tolerance to selenoprotein loss differs between human and mouse. (2019) (26)
- Genetic and functional analysis of mammalian Sep15 selenoprotein. (2002) (26)
- High Error Rates in Selenocysteine Insertion in Mammalian Cells Treated with the Antibiotic Doxycycline, Chloramphenicol, or Geneticin* (2013) (26)
- Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis. (2013) (26)
- Diversity of Plant Methionine Sulfoxide Reductases B and Evolution of a Form Specific for Free Methionine Sulfoxide (2013) (26)
- The Ground Zero of Organismal Life and Aging. (2020) (26)
- Mechanism-based Proteomic Screening Identifies Targets of Thioredoxin-like Proteins* (2015) (26)
- Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity (2020) (25)
- Selenocysteine insertion directed by the 3′-UTR SECIS element in Escherichia coli (2005) (25)
- Reversibility of irreversible aging (2019) (25)
- A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription (2021) (25)
- ARDD 2020: from aging mechanisms to interventions (2020) (25)
- Selenocysteine tRNA identification in the model organisms Dictyostelium discoideum and Tetrahymena thermophila. (2005) (24)
- Tandem use of selenocysteine: adaptation of a selenoprotein glutaredoxin for reduction of selenoprotein methionine sulfoxide reductase (2011) (24)
- Regulation of HIF-1α activity by overexpression of thioredoxin is independent of thioredoxin reductase status (2013) (24)
- Rhesus Monkey Simian Immunodeficiency Virus Infection as a Model for Assessing the Role of Selenium in AIDS (2002) (23)
- The First International Mini-Symposium on Methionine Restriction and Lifespan (2014) (23)
- A Study in Modeling Low-Conservation Protein Superfamilies (2004) (23)
- dbTEU: a protein database of trace element utilization (2010) (23)
- Identification and Characterization of Alternatively Transcribed Form of Peroxiredoxin IV Gene That Is Specifically Expressed in Spermatids of Postpubertal Mouse Testis* (2011) (23)
- Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis (2022) (22)
- A 4-Selenocysteine, 2-Selenocysteine Insertion Sequence (SECIS) Element Methionine Sulfoxide Reductase from Metridium senile Reveals a Non-catalytic Function of Selenocysteines*♦ (2011) (22)
- Selenium and Selenoprotein Deficiencies Induce Widespread Pyogranuloma Formation in Mice, while High Levels of Dietary Selenium Decrease Liver Tumor Size Driven by TGFα (2013) (22)
- svist4get: a simple visualization tool for genomic tracks from sequencing experiments (2019) (22)
- "Preface" to Selenium: Its Molecular Biology and Role in Human Health, Second Edition (2006) (22)
- Genomics perspective on disulfide bond formation. (2003) (22)
- Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans (2018) (21)
- Aging and drug discovery (2018) (21)
- Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera (2017) (21)
- A novel stem loop control element‐dependent UGA read‐through system without translational selenocysteine incorporation in Drosophila (2009) (20)
- A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3'-UTR. (2007) (20)
- Adjustments, extinction, and remains of selenocysteine incorporation machinery in the nematode lineage (2014) (20)
- A review of the biomedical innovations for healthy longevity (2017) (20)
- Comparison of the redox chemistry of sulfur‐ and selenium‐containing analogs of uracil (2017) (20)
- Selenocysteine tRNA[Ser]Sec, the Central Component of Selenoprotein Biosynthesis: Isolation, Identification, Modification, and Sequencing. (2015) (19)
- Selenophosphate synthetase 1 and its role in redox homeostasis, defense and proliferation (2018) (19)
- Cell Proliferation and Motility Are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells (2015) (19)
- Identity, evolution and function of selenoproteins and selenoprotein genes (2001) (19)
- Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity. (2020) (19)
- Historical Roles of Selenium and Selenoproteins in Health and Development: The Good, the Bad and the Ugly (2021) (18)
- Bioinformatics of selenoproteins. (2020) (17)
- Abrogated Thioredoxin System Causes Increased Sensitivity to TNF-α-Induced Apoptosis via Enrichment of p-ERK 1/2 in the Nucleus (2013) (17)
- Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism. (2012) (17)
- Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming (2019) (17)
- Molecular signatures of aneuploidy-driven adaptive evolution (2020) (17)
- Molecular damage in aging (2021) (17)
- The Drosophila Selenoprotein BthD Is Required for Survival and Has a Role in Salivary Gland Development (2003) (16)
- Translation elongation rate varies among organs and decreases with age (2020) (16)
- Selenium utilization in thioredoxin and catalytic advantage provided by selenocysteine. (2015) (16)
- A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging. (2018) (16)
- Comparative genomics analysis of the metallomes. (2013) (16)
- Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy (2015) (16)
- Intrinsic Versus Extrinsic Cancer Risk Factors and Aging. (2016) (15)
- MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII. (2020) (15)
- Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P (2017) (15)
- Thioredoxin and peptide methionine sulfoxide reductase: Convergence of similar structure and function in distinct structural folds (2002) (15)
- Selenocysteine tRNA [Ser]Sec : From Nonsense Suppressor tRNA to the Quintessential Constituent in Selenoprotein Biosynthesis (2016) (15)
- Latest advances in aging research and drug discovery (2019) (14)
- Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2 (2011) (14)
- Selenium and Male Reproduction (2011) (14)
- Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology. (2010) (13)
- CTELS: A Cell-Free System for the Analysis of Translation Termination Rate (2020) (13)
- Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration (2020) (13)
- Defining molecular basis for longevity traits in natural yeast isolates (2015) (13)
- Critical dynamics of gene networks is a mechanism behind ageing and Gompertz law (2015) (13)
- Selenoproteins Harboring a Split Personality in Both Preventing and Promoting Cancer (2011) (12)
- Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation (2019) (12)
- The Insertion Green Monster (iGM) Method for Expression of Multiple Exogenous Genes in Yeast (2014) (12)
- Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner (2018) (12)
- Thiol Peroxidase Deficiency Leads to Increased Mutational Load and Decreased Fitness in Saccharomyces cerevisiae (2014) (12)
- Selenocysteine Biosynthesis, Selenoproteins, and Selenoproteomes (2010) (12)
- Multiple levels of regulation of selenoprotein biosynthesis revealed from the analysis of human glioma cell lines. (2000) (12)
- Proteomics: mapping reactive cysteines. (2011) (12)
- In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan (2022) (12)
- Chapter 25. Selenium in biology and human health: Controversies and perspectives (2001) (12)
- Genetic and phenotypic analysis of the causal relationship between aging and COVID-19 (2021) (12)
- Epigenetic aging of the demographically non-aging naked mole-rat (2022) (12)
- Insights into the Chemical Biology of Selenium (2008) (11)
- Redox regulation of cell signaling by thioredoxin reductases. (2002) (11)
- Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages. (2011) (11)
- Germline burden of rare damaging variants negatively affects human healthspan and lifespan (2019) (11)
- Epigenetic predictors of maximum lifespan and other life history traits in mammals (2021) (11)
- Selenoprotein MsrB1 deficiency exacerbates acetaminophen-induced hepatotoxicity via increased oxidative damage. (2017) (11)
- DNA Methylation Networks Underlying Mammalian Traits (2021) (11)
- Processive Recoding and Metazoan Evolution of Selenoprotein P: Up to 132 UGAs in Molluscs (2019) (11)
- Systematic age‐, organ‐, and diet‐associated ionome remodeling and the development of ionomic aging clocks (2020) (11)
- Selenium and the 15kDa Selenoprotein Impact Colorectal Tumorigenesis by Modulating Intestinal Barrier Integrity (2021) (11)
- Diversity of Protein and mRNA Forms of Mammalian Methionine Sulfoxide Reductase B1 Due to Intronization and Protein Processing (2010) (10)
- COVID-19 mortality rate in children is U-shaped (2021) (10)
- The naked mole rat genome: understanding aging through genome analysis (2011) (10)
- In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation (2019) (10)
- Emerging rejuvenation strategies—Reducing the biological age (2021) (10)
- Maintenance of genome sequence integrity in long- and short-lived rodent species (2021) (10)
- Selective reduction of methylsulfinyl-containing compounds by mammalian MsrA suggests a strategy for improved drug efficacy. (2011) (10)
- Age-associated molecular changes are deleterious and may modulate life span through diet (2017) (10)
- Um34 in selenocysteine tRNA is required for the expression of stress-related selenoproteins in mammals (2005) (10)
- Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan (2016) (10)
- Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast (2021) (9)
- Characterization of protein targets of mammalian thioredoxin reductases. (2010) (9)
- Identification of molybdopterins in molybdenum- and selenium-containing enzymes. (1995) (9)
- Lifespan Extension in Long-Lived Vertebrates Rooted in Ecological Adaptation (2021) (9)
- The roles of thiol oxidoreductases in yeast replicative aging (2010) (9)
- Ectopic cervical thymi and no thymic involution until midlife in naked mole rats (2021) (8)
- Pathogenic Variants in Selenoproteins and Selenocysteine Biosynthesis Machinery (2021) (8)
- Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice (2017) (8)
- Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes (2020) (8)
- Structural Analysis of Glutaredoxin Domain of Mus musculus Thioredoxin Glutathione Reductase (2012) (8)
- Practical guide for dynamic monitoring of protein oxidation using genetically encoded ratiometric fluorescent biosensors of methionine sulfoxide. (2016) (7)
- Analysis of Selenocysteine‐Containing Proteins (2000) (7)
- SelenoP in Metazoa and Molluscs. (2019) (7)
- The Second International Conference “Genetics of Aging and Longevity” (2012) (7)
- Selenium and Methionine Sulfoxide Reduction. (2014) (7)
- How can aging be reversed? Exploring rejuvenation from a damage‐based perspective (2020) (7)
- Rapamycin treatment during development extends lifespan and healthspan (2022) (7)
- A naked mole rat iPSC line expressing drug-inducible mouse pluripotency factors developed from embryonic fibroblasts. (2018) (7)
- Cytochrome c peroxidase facilitates the beneficial use of H2O2 in prokaryotes (2017) (7)
- The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I). (2017) (7)
- Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna (2022) (7)
- Ultra-cheap and scalable epigenetic age predictions with TIME-Seq (2021) (7)
- On Modeling Protein Superfamilies with Low Primary Sequence Conservation (2003) (6)
- NMR assignments of 1H, 13C and 15N spectra of methionine sulfoxide reductase B1 from Mus musculus (2007) (6)
- Use of environmental scanning electron microscopy for in situ observation of interaction of cells with micro- and nanoprobes (2011) (6)
- [Draft macronuclear genome of a ciliate Euplotes crassus]. (2012) (6)
- A New Class of Thioredoxin-Related Protein Able to Bind Iron-Sulfur Clusters. (2016) (6)
- Identification of Signaling Pathways for Early Embryonic Lethality and Developmental Retardation in Sephs1−/− Mice (2021) (6)
- Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activity and sperm motility in mice (2021) (6)
- Ectopic cervical thymi and no thymic involution until midlife in naked mole-rats (2021) (6)
- Organ-specific translation elongation rates measured by in vivo ribosome profiling (2018) (6)
- Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis (2022) (5)
- Development of a novel fluorescent biosensor for dynamic monitoring of metabolic methionine redox status in cells and tissues. (2021) (5)
- Biological age is increased by stress and restored upon recovery (2022) (5)
- Monitoring of Methionine Sulfoxide Content and Methionine Sulfoxide Reductase Activity. (2018) (5)
- Multi-faceted deregulation of gene expression and protein synthesis with age (2020) (5)
- An NMR-based biosensor to measure stereo-specific methionine sulfoxide reductase (MSR) activities in vitro and in vivo. (2020) (5)
- The selenoprotein methionine sulfoxide reductase B1 (MSRB1). (2022) (5)
- Selenocysteine Machinery Primarily Supports TXNRD1 and GPX4 Functions and Together They Are Functionally Linked with SCD and PRDX6 (2022) (5)
- High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E. (2020) (5)
- Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation (2021) (5)
- Multi-omic rejuvenation and lifespan extension upon exposure to youthful circulation (2021) (5)
- A chromosome‐level genome of Antechinus flavipes provides a reference for an Australian marsupial genus with male death after mating (2021) (5)
- Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen (2021) (5)
- Postgenomic chemistry (IUPAC Technical Report) (2005) (4)
- Meeting Report: Aging Research and Drug Discovery (2022) (4)
- Pathways in De Novo Biosynthesis of Selenocysteine and Cysteine in Eukaryotes (2016) (4)
- Characterization of naked mole‐rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits (2022) (4)
- A standard knockout procedure alters expression of adjacent loci at the translational level (2021) (4)
- PRC2 clock: a universal epigenetic biomarker of aging and rejuvenation (2022) (4)
- Analysis and Functional Prediction of Reactive Cysteine (2012) (4)
- Selenium and Cancer (2017) (4)
- CHAPTER 2:Abundance, Ubiquity and Evolution of Molybdoenzymes (2016) (4)
- Selenoproteins in parasites (2006) (4)
- The 15 kDa selenoprotein (Sep15): functional studies and a role in cancer etiology (2001) (4)
- Causal Epigenetic Age Uncouples Damage and Adaptation (2022) (4)
- Sep15 knockout in mice provides protection against chemically‐induced aberrant crypt formation (2011) (3)
- The 15-kDa selenoprotein (Sep15): functional analysis and role in cancer (2006) (3)
- Comparison of selenium-containing molybdoenzymes. (2002) (3)
- Knocking down selenoprotein T (SelT) alters cell adhesion and elevates selenoprotein W (SelW) expression in murine fibroblast cells. (2009) (3)
- Selenocysteine Biosynthesis and the Replacement of Selenocysteine with Cysteine in the Pathway (2011) (3)
- Deterioration of the human transcriptome with age due to increasing intron retention and spurious splicing (2022) (3)
- Epigenetic clocks, aging, and cancer (2022) (3)
- Interplay of Selenoproteins and Different Antioxidant Systems in Various Cancers (2016) (3)
- MOUSE MITOCHONDRIAL THIOREDOXIN REDUCTASE : CHARACTERIZATION OF ALTERNATIVE CYTOSOLIC FORMS AND CELLULAR TARGETS (2006) (3)
- The hematopoietic landscape at single-cell resolution reveals unexpected stem cell features in naked mole-rats (2019) (3)
- Intergenerational hormesis is regulated by heritable 18S rRNA methylation (2021) (3)
- Computational Redox Biology: Methods and Applications (2013) (3)
- Naked Mole-Rat Hematopoietic Stem and Progenitors are Highly Quiescent with an Inherent Myeloid Bias (2021) (3)
- 1H, 15N and 13C NMR assignments of mouse methionine sulfoxide reductase B2 (2008) (3)
- Genetic and Phenotypic Evidence for the Causal Relationship Between Aging and COVID-19 (2020) (3)
- Nature of epigenetic aging from a single-cell perspective (2022) (2)
- Aging Predisposes B cells to Malignancy by Activating c-Myc and Perturbing the Genome and Epigenome (2021) (2)
- The Presence of Mitochondrial Thioltransferase (Grx2) and its Protective and Regenerative Roles of Ascorbic Acid in Human Lens Epithelial Cells (2003) (2)
- Applying deductive reasoning and the principles of particle physics to aging research (2021) (2)
- Evolution of Natural Lifespan Variation and Molecular Strategies of Extended Lifespan (2020) (2)
- The landscape of longevity across phylogeny (2020) (2)
- Measuring Organ-Specific Translation Elongation Rate in Mice. (2021) (2)
- Systematic identification of yeast mutants with increased rates of cell death reveals rapid stochastic necrosis associated with cell division (2021) (2)
- Cell Proliferation and Motility Are Inhibited by G 1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells (2015) (2)
- An NMR-based biosensor to measure stereo-specific methionine sulfoxide reductase (MSR) activities in vitro and in vivo (2020) (2)
- Sep15 knockdown decreases tumorigenicity and metastasis of a colon cancer cell line (2009) (1)
- Assessing Ribosome Distribution Along Transcripts with Polarity Scores and Regression Slope Estimates. (2021) (1)
- Recharging oxidative protein repair: Catalysis by methionine sulfoxide reductases towards their amino acid, protein, and model substrates (2012) (1)
- Identification of catalytic redox‐active cysteines by detecting sporadic cysteine/selenocysteine pairs in homologous sequences (2007) (1)
- Selenophosphate Synthetase 1 is an Essential Protein with Roles in Regulation of Redox Homeostasis and in Malignancy in Mouse Cells (2016) (1)
- Concerning self-excited oscillations in frontal combustion of a fuel mixture in a resonator with lumped parameters (1999) (1)
- Selenoproteome of kinetoplastids. (2013) (1)
- Evolution of selenocysteine decoding and the key role of selenophosphate synthetase in the pathway of selenium utilization (2006) (1)
- A chromosome-level genome of Antechinus flavipes provides a reference for an Australasian marsupial genus with suicidal reproduction (2021) (1)
- A Chromosome-Level Genome of the Agile Gracile Mouse Opossum (Gracilinanus agilis) (2021) (1)
- Use of selenocysteine, the 21st amino acid, in the fungal kingdom (2018) (1)
- Mammalian and other eukaryotic selenocysteine tRNAs (2006) (1)
- NMR assignments of 1 H , 13 C and 15 N spectra of methionine sulfoxide reductase B 1 from Mus musculus (2013) (1)
- 1H, 13C, and 15N NMR resonance assignments of reduced full length and shortened forms of the Grx domain of Mus musculus TGR (2012) (1)
- EPIGENETIC AGING OF THE DEMOGRAPHICALLY NONAGING NAKED MOLE RAT (2022) (1)
- Selenocysteine-Containing Proteins in Mammals (1999) (1)
- Characterization of peptide Methionine oxidation and Methionine sulfoxide reduction using Methionine‐rich proteins (2009) (1)
- Naked Mole-Rat Hyaluronan Synthase 2 Promotes Longevity and Enhances Healthspan in Mice (2022) (1)
- Mouse models for assessing the role of selenoproteins in health and development (2006) (1)
- The transcriptome of the bowhead whale (2014) (1)
- Impact of 15kDa Selenoprotein and Dietary Selenium on Initiation and Promotion in Colorectal Carcinogenesis (2016) (1)
- Epigenetic profiling and incidence of disrupted development point to gastrulation as aging ground zero in Xenopus laevis (2022) (1)
- SEPHS1: Its evolution, function and roles in development and diseases. (2022) (1)
- Evolutionary transcriptomics reveals longevity mostly driven by polygenic and indirect selection in mammals (2023) (1)
- The genome of North American beaver provides insights into the mechanisms of its longevity and cancer resistance (2020) (1)
- TIME-Seq Enables Scalable and Inexpensive Epigenetic Age Predictions (2022) (1)
- TXNRD3 supports male fertility via the redox control of spermatogenesis (2021) (1)
- Potential Role of the 15kDA Selenoprotein in Colorectal Inflammation (2015) (1)
- Formate dehydrogenase in a reversed micelle system: regulation of catalytic activity and oligomeric composition of the enzyme. (1997) (1)
- Structure-Functional Analysis of Mammalian MsrB2 protein (2010) (0)
- Mammalian thioredoxin reductases: roles in redox homeostasis and analysis of cellular targets (2008) (0)
- Organization of the Mammalian IonomeAccording to Organ Origin, LineageSpecialization, and Longevity (2015) (0)
- 1H, 15N and 13C NMR assignments of mouse methionine sulfoxide reductase B2 (2009) (0)
- Involvement of Sep15 family members in immune response (2009) (0)
- DigitalCommons@University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Molybdoproteomes and evolution of molybdenum utilization Molybdoproteomes and evolution of molybdenum utilization (2019) (0)
- Patterns of aging biomarkers, mortality, and damaging mutations illuminate the beginning of aging and causes of early-life mortality (2020) (0)
- Mammalian selenocysteine tRNA Um34 methylase and its role in selenoprotein synthesis (2012) (0)
- siRNA knockdown‐mRNA knock‐in as a means of assessing elenoprotein function (2006) (0)
- Increased sodium selenite cytotoxicity in thioredoxin reductase 1 knockdown cancer cells (2011) (0)
- SIRT 6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species Graphical (2019) (0)
- Antibiotics induce mistranslation of selenocysteine residue in selenoproteins (2012) (0)
- Rilmenidine mimics caloric restriction via the nischarin I1-imidazoline receptor to extend lifespan in C. elegans (2021) (0)
- Examination of anticancer mechanisms in ras‐induced cancer cells by targeting thioredoxin reductase 1 knockdown (2007) (0)
- FROM MECHANISMS OF LIFESPAN CONTROL TO LONGEVITY INTERVENTIONS (2020) (0)
- Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology (2023) (0)
- MITOCHONDRIAL THIOLTRANSFERASE (Grx2) PROTECTS HUMAN LENS EPHITHELIAL CELLS FROM H2O2–INDUCED APOPTOSIS (2004) (0)
- DNA methylation aging clocks: challenges and recommendations (2019) (0)
- Chronic Exposure to Youthful Circulation Leads to Epigenetic Reprogramming and Lifespan Extension (2021) (0)
- NMR solution structure of mouse SelW (2006) (0)
- 1H, 13C, and 15N NMR resonance assignments of reduced full length and shortened forms of the Grx domain of Mus musculus TGR (2011) (0)
- Thioredoxin reductase 1: Role in oxidative stress within cancer cells (2012) (0)
- Insights into the chemical biology of selenium RS (2017) (0)
- Solution structure of SelM from Mus musculus (2005) (0)
- Aging Predisposes B cells to Malignancy by Activating c-Myc and Perturbing the Genome and Epigenome (2021) (0)
- Conditional knockout of selenocysteine tRNA gene (trsp) in liver modulates lipoprotein metabolism (2007) (0)
- 1H, 13C, and 15N NMR resonance assignments of Sec95Cys MsrB1 protein (2007) (0)
- Selenocysteine incorporation in metazoa: the peculiar case of the nematode lineage (2013) (0)
- Chapter 13. The 15 kDa selenoprotein (Sepl5): functional studies and a role in cancer etiology (2001) (0)
- Metabolism, homeostasis, and aging (2023) (0)
- Removal of Glutathione Peroxidase 4 in Mouse Liver Leads to Early Lethality and Vitamin E Can Compensate for Its Loss (2016) (0)
- Comparative Genomics of Trace Elements: Emerging Dynamic View of Trace Element Utilization and Function (2010) (0)
- ROBUST BIOMARKERS OF AGING AND THEIR BIOLOGICAL ORIGIN (2019) (0)
- SECIS‐ and UGA position‐dependent incorporation of selenocysteine into mammalian selenoproteins (2012) (0)
- ClockBase: a comprehensive platform for biological age profiling in human and mouse (2023) (0)
- The Naked Mole Rat and Selenium (2016) (0)
- The selenoproteome of the malarial parasite Plasmodium falciparum as potential drug target (2006) (0)
- Insights into the Chemical Biology of Selenium . pdf (2017) (0)
- Mitochondrial and Nuclear Isoform of Thioltransferase (Grx2) Has Peroxidase Activity in Lens Epithelial Cells (2005) (0)
- UNDERSTANDING AGING AND REDOX CONTROL THROUGH GENOME ANALYSIS (2013) (0)
- A comparative analysis of selenoproteins and global gene expression in liver selenocysteine tRNA knockout mice and its rescued variants (2006) (0)
- Catalytic Mechanism of Eukaryotic Selenocysteine Synthase (2009) (0)
- The Euplotes crassus selenoproteome (2009) (0)
- MOLECULAR MECHANISMS OF NEIGHBORING GENE EFFECT IN THE YEAST KNOCKOUT LIBRARY (2020) (0)
- Mouse Models that Target Removal or Overexpression of the Selenocysteine tRNA (Ser)Sec Gene to Elucidate the Role of Selenoproteins in Health and Development (2011) (0)
- Characterization of Sep15, a novel thioredoxin‐like selenoprotein, and its interaction with UDP‐glucose:glycoprotein glucosyltransferase (2006) (0)
- Endoplasmic reticulum-localized selenoproteins in insulin resistance (2012) (0)
- Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1‐imidazoline receptor (2023) (0)
- Results and Discussion Analysis of gene expression to elucidate lifespan and other life-history strategies (2015) (0)
- Papel de las selenoproteínas en la función de células T y macrófagos (2011) (0)
- DigitalCommons@University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln The prokaryotic selenoproteome The prokaryotic selenoproteome (2019) (0)
- Mammalian thioredoxin reductases: roles in redox homeostasis and analysis of cellular targets (2007) (0)
- Expression of Sep15, a thioredoxin‐like selenoprotein, is induced in response to accumulation of unfolded proteins in the endoplasmic reticulum (2007) (0)
- Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P (2017) (0)
- The Roles of Thioredoxin Reductases in Cell Signaling (2005) (0)
- Crystal Structure of Mouse Thioredoxin Reductase Type 2 (2005) (0)
- Author response: A whole lifespan mouse multi-tissue DNA methylation clock (2018) (0)
- Population genomics of finless porpoises reveal an incipient cetacean species adapted to freshwater (2018) (0)
- Functional analysis of phospholipid hydroperoxide glutathione peroxidase by targeting its expression (2008) (0)
- Role of the 15kDa selenoprotein (Sep15) in colon cancer prevention (2010) (0)
- Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo (2017) (0)
- Modulation of Intestinal Microbiota by Dietary Selenium and 15kDa Selenoprotein Expression in Inflammatory Colon Cancer (2015) (0)
- Ssk2 MAPKKK governs the unique regulation of the stress-activated hog1 pathway in human fungal pathogen cryptococcus neoformans (2008) (0)
- Corrections (1969) (0)
- SYSTEMS AGING AND REJUVENATION (2022) (0)
- svist4get: a simple visualization tool for genomic tracks from sequencing experiments (2019) (0)
- The adaptor for stress‐related selenoprotein synthesis does not require aminoacylation for its maturation (2008) (0)
- Abstract 10272: Alteration of the Selenoproteome by Cellular Hypomethylation Promotes Endothelial Cell Activation (2013) (0)
- DNA Methylation Markers to Assess Biological Age (2018) (0)
- Reduced utilization of selenium during evolution of mammals (2007) (0)
- Identification of a Novel System for Boron Transport: Atr1 Is a Main Boron Exporter in Yeast (cid:1) † (2009) (0)
- Hypoxic HIF‐independent regulation of thioredoxin reductase 1 expression (2011) (0)
- Intrinsic vs . Extrinsic Cancer Risk Factors and Aging (2016) (0)
- Structural Characterization of Mammalian Selenoproteins (2011) (0)
- Solution structure of Sep15 from Drosophila melanogaster (2005) (0)
- Utilization of selenocysteine in early-branching fungal phyla (2019) (0)
- Functional analysis of yeast fRMsr and its role in the reduction of free methionine‐R‐sulfoxides in yeast and mammalian cells (2009) (0)
- Mammalian Selenoprotein Thioredoxin-glutathione Reductase Mammalian Selenoprotein Thioredoxin-glutathione Reductase (2019) (0)
- Coordination ofselenium tomolybdenum informate dehydrogenase H fromEscherichia coli (1994) (0)
- Structure-functional characterization of Grx domain of Mus musculus TGR (2013) (0)
- DNA METHYLATION CLOCKS IN MOUSE (2019) (0)
- Abstract 16739: Impaired Nedd9-smad3 Binding Upregulates Collagen III Synthesis in Human Pulmonary Artery Endothelial Cells in vitro to Promote Pulmonary Arterial Hypertension in vivo (2017) (0)
- Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis (2022) (0)
- Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner (2018) (0)
- Longevity and rejuvenation effects of cell reprogramming are decoupled from loss of somatic identity (2022) (0)
- Molecular signatures of aneuploidy-driven adaptive evolution (2020) (0)
- Crystal structure of the selenocysteine, molybdopterin and 4Fe4S cluster-containing enzyme formate dehydrogenase-H (1996) (0)
- Association between A NOVEL MAMMALIAN 15 kDa selenoprotein and cancer (1998) (0)
- Increased sensitivity of thioredoxin reductase 1 deficient breast cancer cells against TNF‐α induced apoptosis (2009) (0)
- The microbial selenoproteome of the Sargasso Sea The microbial selenoproteome of the Sargasso Sea (2019) (0)
- Genomic and ecosystem evidence demonstrate the importance of selenium for the harmful alga, Aureococcus anophagefferens (2013) (0)
- Protein-coding potential of the human repetitive elements (2022) (0)
- Genome Sequencing and Analysis of the Naked Mole Rat Reveal Insights into Physiology and Longevity (2012) (0)
- Structure of reduced mouse Methionine Sulfoxide Reductase B1 (Sec95Cys Mutant) (2008) (0)
- Mitigating age-related somatic mutation burden. (2023) (0)
- Naked mole rat iPSCs and their noncanonical features: a novel tool for aging research (2021) (0)
- Selenium Imaging in Mouse Tissues (2009) (0)
- Gene expression and protein synthesis remodeling in response to iron deficiency in yeast (2022) (0)
- James R. Mitchell (1971-2020). (2021) (0)
- Mechanisms of cancer resistance in long-lived mammals (2018) (0)
- Influence of selenoprotein methionine‐R‐sulfoxide reductase B1 on the lifespan of fruit flies (2009) (0)
- Relative importance of human and mouse selenoproteins (2021) (0)
- Impact of selenium and selenoproteins on regulation of glucose homeostasis and insulin sensitivity in mice (2008) (0)
- Functional analysis of mammalian selenocysteine synthase (2008) (0)
- How Selenocysteine Altered Our Understanding Of Redox Biology (2017) (0)
- Redox control of the metabolome and the aging process (2017) (0)
- New Techniques for Generation and Analysis of Evolutionary Trees (2004) (0)
- Cost-effective epigenetic age profiling in shallow methylation sequencing data (2021) (0)
- DigitalCommons@University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Selenium and methionine sulfoxide reduction Selenium and methionine sulfoxide reduction (2019) (0)
- Potential Role of the 15kDa Selenoprotein in Colorectal Inflammation (2016) (0)
- Tandem Use of Selenocysteine: Adaptation of a Selenoprotein Glutaredoxin for Reduction of Selenoprotein Methionine Sulfoxide Reductase (2011) (0)
- Thermoacoustic instability of a plasma (1988) (0)
- Cellular Genetics: Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in S. cerevisiae (2014) (0)
- Erratum (1981) (0)
- Comparative genomic analyses of trace element utilization and evolution (2009) (0)
- One codon – two amino acids. (2009) (0)
- Abstract 12207: NEDD9 Cysteinyl Thiol Oxidation Impairs NEDD9 Binding by Smad3 to Increase Pulmonary Endothelial Matrix Metalloproteinase-2 Proteolytic Activity (2016) (0)
- Independent down‐regulation of Sep15 and TR1, but not deficiency in both genes, affects cancer phenotypes of mouse colon carcinoma cells (2012) (0)
- Author response: Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast (2021) (0)
This paper list is powered by the following services:
Other Resources About Vadim N. Gladyshev
What Schools Are Affiliated With Vadim N. Gladyshev?
Vadim N. Gladyshev is affiliated with the following schools:
