Gregory L. Verdine
#57,366
Most Influential Person Now
American chemical biologist
Gregory L. Verdine's AcademicInfluence.com Rankings
Gregory L. Verdinechemistry Degrees
Chemistry
#1370
World Rank
#2067
Historical Rank
#526
USA Rank
Organic Chemistry
#309
World Rank
#374
Historical Rank
#82
USA Rank
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Chemistry
Gregory L. Verdine's Degrees
- PhD Chemistry Columbia University
Why Is Gregory L. Verdine Influential?
(Suggest an Edit or Addition)According to Wikipedia, Gregory L. Verdine is an American chemical biologist, biotech entrepreneur, venture capitalist and university professor. He is a founder of the field of chemical biology, which deals with the application of chemical techniques to biological systems. His work has focused on mechanisms of DNA repair and cell penetrability.
Gregory L. Verdine's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. (1998) (1400)
- Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix (2004) (1179)
- Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA (2000) (856)
- An All-Hydrocarbon Cross-Linking System for Enhancing the Helicity and Metabolic Stability of Peptides (2000) (775)
- The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun (1993) (769)
- Regulation of MLL1 H3K4 methyltransferase activity by its core components (2006) (728)
- Direct inhibition of the NOTCH transcription factor complex (2009) (465)
- Structure of the NF-κB p50 homodimer bound to DNA (1995) (434)
- A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. (2006) (432)
- Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA. (1987) (427)
- Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily (1996) (421)
- DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe. (1997) (390)
- A stapled BID BH3 helix directly binds and activates BAX. (2006) (388)
- Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide (2007) (351)
- Stapled peptides for intracellular drug targets. (2012) (343)
- The crystal structure of Haelll methyltransferase covalently complexed to DNA: An extrahelical cytosine and rearranged base pairing (1995) (341)
- The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members (2007) (317)
- A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer (1997) (315)
- Direct inhibition of the NOTCH transcription factor complex (2010) (308)
- Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis (2011) (297)
- Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA (2005) (290)
- Nonspecifically bound proteins spin while diffusing along DNA (2009) (286)
- Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase (2004) (285)
- Crystal Structure of a Human Alkylbase-DNA Repair Enzyme Complexed to DNA Mechanisms for Nucleotide Flipping and Base Excision (1998) (272)
- Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF (1997) (266)
- Molecular cloning and overexpression of the human FK506-binding protein FKBP (1990) (265)
- Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex (2006) (246)
- DNA methyltransferases. (1994) (241)
- Structural Basis for the Excision Repair of Alkylation-Damaged DNA (1996) (223)
- Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase. (1991) (217)
- Structure of the stapled p53 peptide bound to Mdm2. (2012) (207)
- Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors (1999) (207)
- Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin (2012) (205)
- DNA glycosylase recognition and catalysis. (2004) (185)
- Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil–DNA glycosylase (2001) (183)
- Nucleotide-dependent Domain Movement in the ATPase Domain of a Human Type IIA DNA Topoisomerase* (2005) (181)
- Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides (2017) (177)
- Structure of a trapped endonuclease III–DNA covalent intermediate (2003) (175)
- Structure of a DNA Glycosylase Searching for Lesions (2006) (175)
- Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM (2002) (164)
- Dynamic association of proteins with the pre-mRNA branch region. (1994) (160)
- DNA Lesion Recognition by the Bacterial Repair Enzyme MutM* (2003) (158)
- The critical active-site amine of the human 8-oxoguanine DNA glycosylase, hOgg1: direct identification, ablation and chemical reconstitution. (1997) (157)
- Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin (2016) (156)
- Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA (2006) (153)
- Towards understanding cell penetration by stapled peptides (2015) (148)
- Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. (2007) (147)
- The combinatorial chemistry of nature. (1996) (142)
- Product-assisted catalysis in base-excision DNA repair (2003) (140)
- Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme (2009) (133)
- Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1. (2003) (131)
- Structure of the NF-kappa B p50 homodimer bound to DNA. (1995) (130)
- Reaction of DNA with chemically or enzymatically activated mitomycin C: isolation and structure of the major covalent adduct. (1986) (127)
- Induced alpha helix in the VP16 activation domain upon binding to a human TAF. (1997) (125)
- Repair of DNA methylphosphotriesters through a metalloactivated cysteine nucleophile. (1993) (122)
- Crystal structure of a thwarted mismatch glycosylase DNA repair complex (1999) (119)
- The leucine zipper domain controls the orientation of AP-1 in the NFAT.AP-1.DNA complex. (1996) (117)
- The α-helical FXXΦΦ motif in p53: TAF interaction and discrimination by MDM2 (1999) (116)
- Structure of the human NF‐κB p52 homodimer‐DNA complex at 2.1 Å resolution (1997) (116)
- Covalent trapping of protein-DNA complexes. (2003) (107)
- Solution Structure of the Core NFATC1/DNA Complex (1998) (106)
- Stitched α-helical peptides via bis ring-closing metathesis. (2014) (103)
- Introduction of all-hydrocarbon i,i+3 staples into alpha-helices via ring-closing olefin metathesis. (2010) (101)
- Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc (1997) (101)
- All-atom model for stabilization of alpha-helical structure in peptides by hydrocarbon staples. (2009) (98)
- A CHEMICAL METHOD FOR SITE-SPECIFIC MODIFICATION OF RNA : THE CONVERTIBLE NUCLEOSIDE APPROACH (1997) (97)
- Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase. (2003) (96)
- ENGINEERING TETHERED DNA MOLECULES BY THE CONVERTIBLE NUCLEOSIDE APPROACH (1991) (94)
- SYNTHESIS OF FUNCTIONALLY TETHERED OLIGODEOXYNUCLEOTIDES BY THE CONVERTIBLE NUCLEOSIDE APPROACH (1990) (94)
- Direct visualization of a DNA glycosylase searching for damage. (2002) (93)
- A second calcineurin binding site on the NFAT regulatory domain. (2000) (91)
- Specific Binding of a Designed Pyrrolidine Abasic Site Analog to Multiple DNA Glycosylases* (1998) (89)
- A Superhelical Spiral in the Escherichia coli DNA Gyrase A C-terminal Domain Imparts Unidirectional Supercoiling Bias* (2005) (85)
- How do DNA repair proteins locate damaged bases in the genome? (1997) (85)
- Crystal structure of Bacillus stearothermophilus UvrA provides insight into ATP-modulated dimerization, UvrB interaction, and DNA binding. (2008) (83)
- Disulfide cross-linked oligunocleotides (1991) (82)
- Molecular basis of bacterial resistance to organomercurial and inorganic mercuric salts (1988) (81)
- Overproduction and dissection of proteins by the expression-cassette polymerase chain reaction. (1990) (80)
- Integration Requires a Specific Interaction of the Donor DNA Terminal 5′-Cytosine with Glutamine 148 of the HIV-1 Integrase Flexible Loop* (2006) (78)
- Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase (2009) (75)
- Repair of oxidatively damaged guanine in Saccharomyces cerevisiae by an alternative pathway (1998) (75)
- DNA methylation through a locally unpaired intermediate (1993) (75)
- Stereochemical effects of all-hydrocarbon tethers in i,i+4 stapled peptides. (2009) (72)
- Structure of human cytidine deaminase bound to a potent inhibitor. (2005) (71)
- Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein. (2001) (70)
- Only one of the two DNA-bound orientations of AP-1 found in solution cooperates with NFATp (1995) (68)
- Trapping of a catalytic HIV reverse transcriptase*template:primer complex through a disulfide bond. (2000) (67)
- A critical arginine residue mediates cooperativity in the contact interface between transcription factors NFAT and AP-1. (1996) (67)
- Investigation of the mechanisms of DNA binding of the human G/T glycosylase using designed inhibitors. (1997) (67)
- Synthesis and characterization of disulfide cross-linked oligonucleotides (1993) (67)
- A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. (2005) (65)
- Solution structure of the DNA methyl phosphotriester repair domain of Escherichia coli Ada. (1993) (65)
- A multifunctional plasmid for protein expression by ECPCR: overproduction of the p50 subunit of NF-κB (1993) (64)
- Transcriptional switching by the metalloregulatory MerR protein: initial characterization of DNA and mercury (II) binding activities. (1989) (64)
- Gene expression: The amazing demethylase (1999) (60)
- All-hydrocarbon stapled peptides as Synthetic Cell-Accessible Mini-Proteins. (2012) (60)
- The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2. (1999) (59)
- Structural Characterization of Human 8-Oxoguanine DNA Glycosylase Variants Bearing Active Site Mutations* (2007) (59)
- Base excision repair. (2004) (59)
- Reaction of acid-activated mitomycin C with calf thymus DNA and model guanines: elucidation of the base-catalyzed degradation of N7-alkylguanine nucleosides. (1987) (58)
- Drugging the "undruggable". (2006) (57)
- Mutational separation of DNA binding from catalysis in a DNA cytosine methyltransferase (1993) (56)
- A synthetic library of cell-permeable molecules. (2001) (54)
- Subunit-specific Protein Footprinting Reveals Significant Structural Rearrangements and a Role for N-terminal Lys-14 of HIV-1 Integrase during Viral DNA Binding* (2008) (54)
- The flip side of DNA methylation (1994) (52)
- A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex (2006) (50)
- An engineered protein antagonist of K-Ras/B-Raf interaction (2017) (49)
- Modifying the helical structure of DNA by design: recruitment of an architecture-specific protein to an enforced DNA bend. (1995) (49)
- Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. (2008) (48)
- Mutagenesis of the cysteines in the metalloregulatory protein MerR indicates that a metal-bridged dimer activates transcription. (1989) (48)
- Specific binding of the DNA repair enzyme AlkA to a pyrrolidine-based inhibitor (1995) (47)
- The Rel family of eukaryotic transcription factors. (1996) (47)
- Dual role of the nuclear factor of activated T cells insert region in DNA recognition and cooperative contacts to activator protein 1. (1997) (46)
- Unusually Strong Binding of a Designed Transition-State Analog to a Base-Excision DNA Repair Protein (1997) (45)
- A Structural Model for the Damage-sensing Complex in Bacterial Nucleotide Excision Repair* (2009) (45)
- Entrapment and Structure of an Extrahelical Guanine Attempting to Enter the Active Site of a Bacterial DNA Glycosylase, MutM* (2009) (45)
- Zinc binding by the methylation signaling domain of the Escherichia coli Ada protein. (1992) (44)
- A nonnatural transcriptional coactivator. (1997) (42)
- Enforced Presentation of an Extrahelical Guanine to the Lesion Recognition Pocket of Human 8-Oxoguanine Glycosylase, hOGG1* (2012) (42)
- A Designed Inhibitor of Base-Excision DNA Repair (1995) (41)
- High-affinity mu opioid receptor ligands discovered by the screening of an exhaustively stereodiversified library of 1,5-enediols. (2002) (40)
- Limited proteolysis and site-directed mutagenesis of the NF-κB p50 DNA-binding subunit (1993) (40)
- Synthesis and biochemical evaluation of RNA containing an intrahelical disulfide crosslink. (1995) (40)
- Reassignment of the guanine-binding mode of reduced mitomycin C. (1986) (38)
- The Positively Charged Surface of Herpes Simplex Virus UL42 Mediates DNA Binding* (2008) (37)
- Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer (2017) (36)
- Immobilized metal affinity chromatography of DNA. (1996) (34)
- The orientation of the AP-1 heterodimer on DNA strongly affects transcriptional potency. (1998) (34)
- Deconstruction of GCN4/GCRE into a monomeric peptide-DNA complex (1995) (33)
- CIRCULAR DICHROISM SPECTROSCOPY AS A PROBE FOR THE STEREOCHEMISTRY OF AZIRIDINE CLEAVAGE REACTIONS OF MITOMYCIN C. APPLICATION TO ADDUCTS OF MITOMYCIN WITH DNA CONSTITUENTS (1984) (33)
- Strandwise translocation of a DNA glycosylase on undamaged DNA (2012) (33)
- Concise enantio- and diastereoselective synthesis of α-hydroxy-α-methyl-β-amino acids (2001) (32)
- Trapping distinct structural states of a protein/DNA interaction through disulfide crosslinking. (2002) (32)
- A New i, i + 3 Peptide Stapling System for α‐Helix Stabilization (2013) (32)
- Metal Dependence of Transcriptional Switching in Escherichia coli Ada (*) (1995) (31)
- A Small Region in HMG I(Y) Is Critical for Cooperation with NF-κB on DNA* (1999) (31)
- The human cytomegalovirus UL44 C clamp wraps around DNA. (2008) (31)
- Evidence for a non-alpha-helical DNA-binding motif in the Rel homology region. (1994) (31)
- The effects of N7-methylguanine on duplex DNA structure. (1994) (30)
- Structures of end products resulting from lesion processing by a DNA glycosylase/lyase. (2004) (30)
- The synthesis of an exhaustively stereodiversified library of cis-1,5 enediols by silyl-tethered ring-closing metathesis. (2001) (30)
- Structure of the E. coli DNA glycosylase AlkA bound to the ends of duplex DNA: a system for the structure determination of lesion-containing DNA. (2008) (29)
- Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution. (1997) (29)
- Total Chemical Synthesis and Folding of All-l and All-d Variants of Oncogenic KRas(G12V). (2017) (29)
- Structural basis for the functional switch of the E. coli Ada protein. (2001) (28)
- Backbone dynamics, amide hydrogen exchange, and resonance assignments of the DNA methylphosphotriester repair domain of Escherichia coli Ada using NMR. (1996) (28)
- Metal-coordination sphere in the methylated Ada protein-DNA co-complex. (1994) (27)
- IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex. (2017) (27)
- Structural studies of the high mobility group globular domain and basic tail of HMG-D bound to disulfide cross-linked DNA. (2000) (27)
- A modular synthetic approach toward exhaustively stereodiversified ligand libraries. (2000) (27)
- A structural snapshot of base-pair opening in DNA. (1999) (26)
- Structure of Escherichia coli AlkA in Complex with Undamaged DNA* (2010) (26)
- Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface (2020) (24)
- Trapping and structural elucidation of a very advanced intermediate in the lesion-extrusion pathway of hOGG1. (2008) (24)
- Mammalian DNA cytosine‐5 methyltransferase interacts with p23 protein (1996) (24)
- Recent applications of circular dichroism to structural problems, especially oligosaccharide structures (1984) (24)
- Unpredictable stereochemical preferences for mu opioid receptor activity in an exhaustively stereodiversified library of 1,4-enediols. (2003) (22)
- A concise synthesis of 4'-fluoro nucleosides. (2007) (22)
- Ratcheting torsional stress in duplex DNA (1993) (21)
- Structural and Biochemical Analysis of DNA Helix Invasion by the Bacterial 8-Oxoguanine DNA Glycosylase MutM* (2013) (21)
- Extensively stereodiversified scaffolds for use in diversity-oriented library synthesis. (2003) (21)
- Selective Inhibition of Herpes Simplex Virus Type-1 Uracil-DNA Glycosylase by Designed Substrate Analogs* 210 (2000) (21)
- 2,6-Dimethyltyrosine analogues of a stereodiversified ligand library: highly potent, selective, non-peptidic mu opioid receptor agonists. (2003) (21)
- Exceptionally high-affinity Ras binders that remodel its effector domain (2017) (20)
- A high-capacity column for affinity purification of sequence-specific DNA-binding proteins (1992) (20)
- Aminolysis of 2'-deoxyinosine aryl ethers : nucleoside model studies for the synthesis of functionally tethered oligonucleotides (1992) (20)
- Template-directed interference footprinting of protein-guanine contacts in DBA (1991) (20)
- Overproduction of proteins using expression-cassette polymerase chain reaction. (1993) (20)
- Structural Determinants for Specific Recognition by T4 Endonuclease V* (1996) (20)
- Aberrantly methylated DNA: site-specific introduction of N-7-methyl-2'-deoxyguanosine into the Dickerson/Drew dodecamer. (1992) (19)
- Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase* (2015) (19)
- Template-directed interference footprinting of cytosine contacts in a protein-DNA complex: potent interference by 5-aza-2'-deoxycytidine. (1992) (19)
- Sequence-dependent Structural Variation in DNA Undergoing Intrahelical Inspection by the DNA glycosylase MutM* (2012) (19)
- Converting the sacrificial DNA repair protein N-ada into a catalytic methyl phosphotriester repair enzyme. (2003) (19)
- The Convertible Nucleoside Approach: Structural Engineering of Nucleic Acids by Disulfide Cross-Linking (1994) (19)
- Molecular dynamics simulations of disulfide cross-linked DNA decamers (1993) (19)
- DNA binding by an amino acid residue in the C-terminal half of the Rel homology region. (1994) (18)
- Construction of an overproduction vector containing the novel srp (sterically repressed) promoter (1994) (18)
- Analysis of an anomalous mutant of MutM DNA glycosylase leads to new insights into the catalytic mechanism. (2009) (18)
- Synthesis of an oligonucleotide suicide substrate for DNA methyltransferases (1992) (18)
- A genotyping strategy based on incorporation and cleavage of chemically modified nucleotides (2002) (17)
- Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase* (2017) (17)
- Structural and mechanistic studies on repair of 8-oxoguanine in mammalian cells. (2000) (16)
- Purification of the major histocompatibility complex class I transcription factor H2TF1. The full-length product of the nfkb2 gene. (1993) (16)
- Nature of the destruction of deoxyguanosine residues by mitomycin C (1985) (16)
- DISULFIDE CROSS-LINKING AS A MECHANISTIC PROBE FOR THE B Z TRANSITION IN DNA (1997) (16)
- Protein overproduction for organic chemists (1991) (15)
- High-resolution footprinting of sequence-specific protein–DNA contacts (2002) (15)
- A DNA-bending protein interacts with an essential upstream regulatory element of the human embryonic beta-like globin gene (1996) (14)
- Synthesis of Functionally Tethered Oligodeoxynucleotides by the Convertible Nucleoside Approach. (1991) (14)
- Use of differential second-derivative UV and FTIR spectroscopy in structural studies of multichromophoric compounds (1985) (14)
- In vitro selection of RNA aptamers against a composite small molecule-protein surface (2005) (13)
- Identification of cyclosporin C from Amphichorda felina using a Cryptococcus neoformans differential temperature sensitivity assay (2018) (13)
- Synthesis of photoactive DNA: incorporation of 8-bromo-2′-deoxyadenosine into synthetic oligodeoxynucleotides (1992) (12)
- The base promoted oligomerization of 15-dehydro-prostaglandin B1: dimer formation and structural implications for a complex mixture termed PGBx (1983) (12)
- All-Atom Model for Stabilization of α-Helical Structure in Peptides by Hydrocarbon Staples (2009) (12)
- Chemical approaches toward understanding base excision DNA repair. (1997) (12)
- A small region in HMG I(Y) is critical for cooperation with NF-kappaB on DNA. (1999) (12)
- The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase (2020) (11)
- Direct observation of a specific contact in the .lambda. repressor-OL1 complex by isotope-edited NMR (1993) (11)
- Direct Activation of the Methyl Chemosensor Protein N-Ada by CH3I (1995) (11)
- Mechanism of DNA Lesion Homing and Recognition by the Uvr Nucleotide Excision Repair System (2019) (10)
- Unusual cis stereoselectivity in an aziridine cleavage reaction of mitomycin C (1987) (10)
- Protein engineering for therapeutics (2012) (10)
- p-Dimethylaminocinnamate, a new red-shifted chromophore for use in the exciton chirality method. Its application to mitomycin C (1985) (9)
- Chemical communication across the zinc tetrathiolate cluster in Escherichia coli Ada, a metalloactivated DNA repair protein. (2001) (9)
- Mapping Targetable Sites on Human Telomerase RNA Pseudoknot/Template Domain Using 2′-OMe RNA-interacting Polynucleotide (RIPtide) Microarrays* (2012) (9)
- DNA repair proteins (1994) (9)
- The base promoted oligomerization of a 15-dehydro-PGB1 analog: Structural insights into the complex oligomeric mixture termed PGBX (1982) (9)
- Conformational analysis of a stereochemically complete set of cis-enediol peptide analogues. (2002) (8)
- Crystallization and preliminary crystallographic analysis of a DNA (cytosine-5)-methyltransferase from Haemophilus aegyptius bound covalently to DNA. (1994) (6)
- 5-amino-2'-deoxyuridine, a novel thymidine analogue for high-resolution footprinting of protein-DNA complexes. (2002) (6)
- Falling out of the fold: tumorigenic mutations and p53. (1994) (6)
- Protein engineering for therapeutics, Part A. Preface. (2012) (5)
- Protein engineering for therapeutics, part B. Preface. (2012) (5)
- Selective base-pair destabilization enhances binding of a DNA methyltransferase (1997) (5)
- Voices of biotech (2016) (4)
- A stapled POL κ peptide targets REV1 to inhibit mutagenic translesion synthesis (2020) (4)
- Solution Structure of the Core NFATC 1 / DNA (1998) (3)
- [19] – Overproduction of Proteins Using Expression-Cassette Polymerase Chain Reaction (1995) (3)
- Structural Origins of DNA Target Selection and Nucleobase Extrusion by a DNA Cytosine Methyltransferase* (2012) (3)
- Nature of the Destruction of Deoxyguanosine Residues by Mitomycin C Activated by Mild Acid pH. (1986) (3)
- Direct Inhibition of the Notch Transactivation Complex with Synthetic Constrained Peptides in T-Cell Acute Lymphoblastic Leukemia. (2007) (3)
- A Concise Synthesis of 4′-Fluoro Nucleosides. (2008) (2)
- Change comes slowly to South Africa (1996) (1)
- 464 Regulation of apoptosis by synthetic helices of the BCL-2 family (2004) (1)
- Crystal Structure of Bacillus stearothermophilus UvrA (2008) (1)
- Selective Targeting of the p53-hDM2 Interaction Using Hydrocarbon-Stapled p53 Peptides. (2006) (1)
- HUMAN TRANSCRIPTION FACTOR NFATC DNA BINDING DOMAIN, NMR, 10 STRUCTURES (1997) (1)
- Structure of a Trapped Endonuclease III-DNA Covalent Intermediate: Estranged-Adenine Complex (2003) (1)
- Anti-Leukemic Potency of Stapled BH3 Helices Correlates with Their Capacity for Bifunctional Activation of Apoptotic Pathways. (2006) (1)
- 3-METHYLADENINE DNA GLYCOSYLASE II FROM ESCHERICHIA COLI (1998) (1)
- Identification of cyclosporin C from Amphichorda felina using a Cryptococcus neoformans differential temperature sensitivity assay (2018) (0)
- Template-directed interference footprinting of protein-phosphate contacts in DNA. (2001) (0)
- Specific interactions of t4 endonuclease v with a proposed transition state analogue for dna glycosylases (1996) (0)
- Crystal Structure of C71S Mutant of DNA Cytosine-5 Methyltransferase M.HaeIII Bound to DNA (2012) (0)
- Sequence-matched MutM Interrogation Complex 4 (IC4) (2009) (0)
- Evidence for a nona-helical DNA-binding motif in the Rel homology region ( photocosik / proteln-DNA lnteractns / tnsclpton factor NF-KB ) (2004) (0)
- KRas G12V, bound to GDP and miniprotein 225-11 (2018) (0)
- MUTM Slanted complex 8 with R112A mutation (2012) (0)
- Drugging "Undruggable" Targets in Cancer (2007) (0)
- WDR5 and unmodified Histone H3 complex at 2.25 angstrom (2006) (0)
- Structure of catalytically inactive Q315A human 8-oxoguanine glycosylase complexed to 8-oxoguanine DNA (2006) (0)
- Crystal Structure of MutY bound to its anti-substrate with the disulfide cross-linker reduced (2015) (0)
- Crystal Structure of an AlkA Host/Guest Complex 2'-fluoro-2'-deoxy-1,N6-ethenoadenine:Thymine Base Pair (2008) (0)
- The Harvey Lectues: Delivered Under the Auspices of The Harvey Society of New York, 2006 -2007 (2010) (0)
- Sequence-matched MutM Lesion Recognition Complex 3 (LRC3) (2009) (0)
- Targeted β‐catenin ubiquitination and degradation by multifunctional stapled peptides (2021) (0)
- MutY N-terminal domain in complex with undamaged DNA (2017) (0)
- Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-aminoguanine (2003) (0)
- SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES (1998) (0)
- MutM containing F114A mutation bound to undamaged DNA (2013) (0)
- Disulfide Trapped Structure of a Repair Enzyme Interrogating Undamaged DNA Sheds Light on Damaged DNA Recognition (2006) (0)
- Microsoft Word-AD-GLV-JBC-MS_glv edit-AD_add_images---final.docx (2012) (0)
- MutY N-terminal domain in complex with DNA containing an intrahelical oxoG:A base-pair (2017) (0)
- Alpha-helical peptides suitable for the activation or inhibition of cell death (2004) (0)
- Structure of catalytically inactive human 8-oxoguanine glycosylase distal crosslink to oxoG DNA (2006) (0)
- Disulfide Trapped Structure of a Repair Enzyme Interrogating Undamaged DNA Sheds Light on Damaged DNA Recognition (2006) (0)
- Drugging "Undruggable" Targets (2007) (0)
- Human 8-oxoguanine glycosylase crosslinked with oxoG lesion containing DNA (2020) (0)
- Human 8-oxoguanine glycosylase crosslinked with guanine containing DNA (2005) (0)
- E. Coli Ada in a complex with DNA (2005) (0)
- Differentiation Induction In Acute Myeloid Leukemia Using Site-Specific DNA-Targeting (2013) (0)
- Methods for synthesis of nucleic acids functionalised (2012) (0)
- MutM (Fpg)-DNA Estranged Guanine Mismatch Recognition Complex (2002) (0)
- Molecular Mechanism of the Acceleration of the Damaged Base Extrusion and its Recognition by Bacterial MutM DNA Glycosylase: Free Energy Simulation Studies (2009) (0)
- Structure of a DNA glycosylase disulfide‐crosslinked sampling an intrahelical damaged base‐pair (2006) (0)
- Sequence-matched MutM Lesion Recognition Complex 5 (LRC5) (2009) (0)
- KRas G12V/D38P, bound to GppNHp and miniprotein 225-11 (2018) (0)
- MutM encountering an intrahelical 8-oxoguanine (oxoG) lesion in EC3-T224P complex (2009) (0)
- Cytosine Methyltransferase and Nucleobase Extrusion by a DNA Structural Origins of DNA Target Selection Protein Structure and Folding : (2012) (0)
- Structure of a non-covalent Endonuclease III-DNA Complex (2003) (0)
- Human 8-oxoguanine glycosylase interrogating fully intrahelical oxoG lesion DNA (2020) (0)
- Crystal Structure of an AlkA Host/Guest Complex 2'-fluoro-2'-deoxyinosine:Thymine Base Pair (2008) (0)
- Use of Differential Second-Derivative UV and FTIR Spectroscopy in Structural Studies of Multichromophoric Compounds. (1986) (0)
- MutM (Fpg) bound to 5,6-dihydrouracil (DHU) containing DNA (2003) (0)
- Crystal Structure of hogg1 D268E Mutant with Base-Excised DNA and 8-aminoguanine (2004) (0)
- MutM (Fpg) Covalent-DNA Intermediate (2002) (0)
- Crystal structure of UvrA-UvrB interaction domains (2009) (0)
- Abstract IA1-2: Drugging oncogenic transcription factors (2010) (0)
- Structure of catalytically inactive H270A human 8-oxoguanine glycosylase crosslinked to 8-oxoguanine DNA (2006) (0)
- Development of α 2 C-subtype Selective Antagonist for Treatment of Cognitive Disorders in Alzheimer ’ s Disease and Schizophrenia (2011) (0)
- Structure of Q315F human 8-oxoguanine glycosylase proximal crosslink to 8-oxoguanine DNA (2006) (0)
- 242 Next-Generation Therapeutics for Unconventional Targets (2012) (0)
- MutM encountering an intrahelical 8-oxoguanine (oxoG) lesion in EC4-loop deletion complex (2009) (0)
- Crystal Structure of Hogg1 D268E Mutant with Product Oligonucleotide (2004) (0)
- Unusual cis Stereoselectivity in an Aziridine Cleavage Reaction of Mitomycin C. (1987) (0)
- MUTM Slanted complex 6 with R112A mutation (2012) (0)
- Cumulative Author Index (2002) (0)
- MutM containing F114A mutation bound to oxoG-containing DNA (2013) (0)
- STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE (1998) (0)
- Catalytically inactive human 8-oxoguanine glycosylase crosslinked to oxoG containing DNA (2005) (0)
- Catalytically inactive human 8-oxoguanine glycosylase crosslinked to 7-deazaguanine containing DNA (2005) (0)
- A Stapled p53 Helix Targets HDMX to Overcome Nutlin-3 Resistance and Reactivate the p53 Tumor Suppressor Pathway in Cancer (2008) (0)
- Crystal Structure of an AlkA Host/Guest Complex 2'-fluoro-2'-deoxyinosine:Adenine Base Pair (2008) (0)
- Catalytically inactive hOGG1 crosslinked with 7-deaza-8-azaguanine containing DNA (2005) (0)
- MUTM Slanted complex 1 (2012) (0)
- NMR structure of E. Coli Ada protein in complex with DNA (2005) (0)
- 69 Computational modeling and molecular optimization of stabilized alpha-helical peptides targeting NOTCH-CSL transcriptional complexes (2010) (0)
- Crystal structure of KRas G12V/D38P, bound to GDP (2018) (0)
- MutM (Fpg) DNA End-Product Structure (2002) (0)
- Crystal structure of UvrB bound to duplex DNA with ADP (2020) (0)
- Crystal Structure of an AlkA Host/Guest Complex 8oxoGuanine:Adenine Base Pair (2008) (0)
- Structure of human 8-oxoGuanine Glycosylase 1 bound to fluorninated oxoG-containing DNA (2010) (0)
- CRYSTAL STRUCTURE OF AN HOGG1-DNA BOROHYDRIDE TRAPPED INTERMEDIATE COMPLEX (2003) (0)
- Abstract 345: Development of a novel and direct peptide Helicon࣪ inhibitor of β-catenin-TCF interaction with in vivo validation of transcriptional modulation and anti-tumor activity (2022) (0)
- DNA DECAMER WITH AN ENGINEERED CROSSLINK IN THE MINOR GROOVE (1999) (0)
- Crystal Structure of Bacillus stearothermophilus UvrC 5' endonuclease domain (2008) (0)
- Abstract PL03-05: Drugging RAS into oblivion (2015) (0)
- KRas G12V, bound to GppNHp and miniprotein 225-11 (2018) (0)
- Crystal Structure of MutY bound to its anti-substrate (2015) (0)
- Concise Enantio‐ and Diastereoselective Synthesis of α‐Hydroxy‐α‐methyl‐β‐amino Acids. (2001) (0)
- Crystal Structure of D144N MutY bound to its anti-substrate (2015) (0)
- Hdmx-mediated antagonism of p53-dependent cell death (2007) (0)
- DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA (1995) (0)
- STRUCTURAL SNAPSHOTS OF BASE EXCISION DNA REPAIR (2006) (0)
- Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer (2017) (0)
- De novo mapping of α-helix recognition sites on protein surfaces using unbiased libraries (2022) (0)
- MutM interrogating an extrahelical G (2009) (0)
- 72 Semi-rational design of β-catenin targeting peptides for the inhibition of Wnt-dependent signaling (2010) (0)
- Catalytically inactive (E3Q) MutM crosslinked to oxoG:C containing DNA CC1 (2006) (0)
- Structure of beta-catenin in complex with a stapled peptide inhibitor (2012) (0)
- HUMAN NF-KAPPA-B P52 BOUND TO DNA (1998) (0)
- Crystal structure of UvrB bound to fully duplex DNA (2020) (0)
- Crystal structure of UvrB mutant bound to duplex DNA (2020) (0)
- THE BASE PROMOTED OLIGOMERIZATION OF 15-DEHYDROPROSTAGLANDIN B1: DIMER FORMATION AND STRUCTURAL IMPLICATIONS FOR A COMPLEX MIXTURE TERMED PGBX (1983) (0)
- hOgg1 Borohydride-Trapped Intermediate without 8-oxoguanine (2003) (0)
- Crystal structure of UvrB bound to duplex DNA (2020) (0)
- Structure of G42A human 8-oxoguanine glycosylase crosslinked to undamaged G-containing DNA (2006) (0)
- MutY adenine glycosylase in complex with DNA containing an abasic site (2004) (0)
- Human 8-oxoguanine glycosylase interrogating fully intrahelical undamaged DNA (2020) (0)
- MutM crosslinked to undamaged DNA sampling A:T base pair IC1 (2006) (0)
- MutM encountering an intrahelical 8-oxoguanine (oxoG) lesion in EC5-loop deletion complex (2009) (0)
- Abstract B37: Development of inhibitors of the activated form of KRAS G12C (2020) (0)
- AlkA Undamaged DNA Complex: Interrogation of a C:G base pair (2010) (0)
- WDR5 and Histone H3 Lysine 4 dimethyl complex at 2.1 angstrom (2006) (0)
- Structure of hOGG1 crosslinked to DNA sampling a normal G adjacent to an oxoG (2006) (0)
- Targeting the Transcriptional Hub ß-Catenin Using Stapled Peptides (2014) (0)
- MutY adenine glycosylase in complex with DNA containing an A:oxoG pair (2004) (0)
- Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA (2010) (0)
- Abstract #841: Targeted disruption of the Notch transcription factor complex in vitro and in vivo (2009) (0)
- Structural effects of sequence context on lesion recognition by MutM (2012) (0)
- HUMAN 3-METHYLADENINE DNA GLYCOSYLASE COMPLEXED TO DNA (1998) (0)
- Direct inhibition of the Notch transactivation complex with stapled peptides in T-ALL (2008) (0)
- MUTM Slanted complex 4 with R112A mutation (2012) (0)
- MutM (Fpg) Bound to Abasic-Site Containing DNA (2002) (0)
- Selective Base-Pair Destabilization Enhances Binding of a DNA Methyltransferase. (1997) (0)
- REFINED STRUCTURE OF THE DNA METHYL PHOSPHOTRIESTER REPAIR DOMAIN OF E. COLI ADA (2003) (0)
- Encountering Small-Molecule Biologicals in Genomic Space (2014) (0)
- MutM (Fpg) bound to 8-oxoguanine (oxoG) containing DNA (2003) (0)
- Crystal Structure of Human Cytidine Deaminase (2003) (0)
- MutM slanted complex 7 (2012) (0)
- Human DNA topoisomerase IIa ATPase/ADP (2005) (0)
- Correction to "Stitched α-Helical Peptides via Bis Ring-Closing Metathesis". (2015) (0)
- MUTM Interrogation complex 6 (2012) (0)
- MutY adenine glycosylase in complex with DNA and soaked adenine free base (2004) (0)
- Former Officers of the Harvey Society (2010) (0)
- MutM lesion recognition control complex with N174C crosslinking site (2009) (0)
- Crystal structure of the methylated N-ADA/DNA complex (2005) (0)
- Stabilized alpha-helix peptides and uses thereof (2004) (0)
- Catalytically inactive (E3Q) MutM crosslinked to oxoG:C containing DNA CC2 (2006) (0)
- KRas G12V, bound to GppNHp and miniprotein 225-11(A30R) (2018) (0)
- Site-specific reversible conjugation: A novel concept in peptide-DNA interactions (1996) (0)
- Crystal structure of CEP250 bound to FKBP12 in the presence of FK506-like novel natural product (2020) (0)
- Human Topo IIa ATPase/AMP-PNP (2005) (0)
- Sequence-matched MutM Interrogation Complex 5 (IC5) (2009) (0)
- Preparation of romidepsina (2007) (0)
- Abstract 4972: Anti-tumor activity of Helicon inhibitors of Β-catenin-TCF interaction in patient-derived xenograft models (2023) (0)
- Crystal Structure of a MUG-DNA pseudo substrate complex (2002) (0)
- KRas G12V, bound to GDP and miniprotein 225-11(A30R) (2018) (0)
- Crystal Structure of MutY bound to its inhibitor DNA (2009) (0)
- CRYSTAL STRUCTURE OF THE HUMAN 8-OXOGUANINE GLYCOSYLASE (HOGG1) BOUND TO A SUBSTRATE OLIGONUCLEOTIDE (2000) (0)
- Crystal Structure of an AlkA Host/Guest Complex 8oxoGuanine:Cytosine Base Pair (2008) (0)
- An engineered protein antagonist of K-Ras/B-Raf interaction (2017) (0)
- MUTM Slanted complex 8 (2012) (0)
- MutM encountering an intrahelical 8-oxoguanine (oxoG) lesion in EC3-loop deletion complex (2009) (0)
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