Anthony Segal

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Anthony Segal is affiliated with the following schools: University of Cape Town, Imperial College London, University of Oxford, University College London, University of Manchester

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Anthony Segal

Biology

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#7071

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Biochemistry

#658

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#756

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Biology

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According to Wikipedia, Anthony Segal FRS FMedSci is a British physician/scientist. Education He was educated at the University of Cape Town and University of London . Fellow of: UCL, Royal College of Physicians, The College of Medicine of South Africa

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Anthony Segal's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

How neutrophils kill microbes. (2005) (1674)
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. (2009) (1247)
Killing activity of neutrophils is mediated through activation of proteases by K+ flux (2002) (1160)
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1 (1991) (936)
Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. (1998) (900)
The biochemical basis of the NADPH oxidase of phagocytes. (1993) (597)
NADPH oxidase. (1996) (589)
The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems. (2004) (471)
Elemental diet as primary treatment of acute Crohn's disease: a controlled trial. (1984) (441)
The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH (1981) (410)
Defective acute inflammation in Crohn's disease: a clinical investigation (2006) (409)
Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. (2000) (402)
Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity. (1994) (397)
Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes. (1992) (349)
Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription. (1997) (333)
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease (2009) (331)
Absence of both cytochrome b−245 subunits from neutrophils in X-linked chronic granulomatous disease (1987) (306)
p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains. (1993) (306)
Novel cytochrome b system in phagocytic vacuoles of human granulocytes (1978) (301)
The X-linked chronic granulomatous disease gene codes for the β-chain of cytochrome b −245 (1987) (275)
Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease. (1996) (270)
Absence of cytochrome b-245 in chronic granulomatous disease. A multicenter European evaluation of its incidence and relevance. (1983) (266)
The electron transport chain of the microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous disease. (1989) (261)
Stimulated neutrophils from patients with autosomal recessive chronic granulomatous disease fail to phosphorylate a Mr-44,000 protein (1985) (243)
Inhibition of lipid peroxidation by the iron-binding protein lactoferrin. (1981) (243)
Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease (2018) (233)
Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245. (1992) (231)
The large-conductance Ca2+-activated K+ channel is essential for innate immunity (2004) (224)
Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (1997) (222)
Intramembrane Bis-Heme Motif for Transmembrane Electron Transport Conserved in a Yeast Iron Reductase and the Human NADPH Oxidase* (1996) (217)
Inflammatory Bowel Disease in CGD Reproduces the Clinicopathological Features of Crohn's Disease (2009) (211)
The enzymic reduction and kinetics of oxidation of cytochrome b-245 of neutrophils. (1982) (201)
Oxidation-reduction properties of the cytochrome b found in the plasma-membrane fraction of human neutrophils. A possible oxidase in the respiratory burst. (1981) (195)
Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease (1996) (190)
NEUTROPHIL DYSFUNCTION IN CROHN'S DISEASE (1976) (190)
ABSENCE OF A NEWLY DESCRIBED CYTOCHROME b FROM NEUTROPHILS OF PATIENTS WITH CHRONIC GRANULOMATOUS DISEASE (1978) (183)
Protein kinase C-beta contributes to NADPH oxidase activation in neutrophils. (2000) (177)
Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane. (1994) (174)
Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils. (1997) (159)
Kinetics of fusion of the cytoplasmic granules with phagocytic vacuoles in human polymorphonuclear leukocytes. Biochemical and morphological studies (1980) (156)
Lipid rafts determine efficiency of NADPH oxidase activation in neutrophils (2003) (153)
The FRE1 Ferric Reductase of Saccharomyces cerevisiae Is a Cytochrome b Similar to That of NADPH Oxidase* (1996) (143)
The production of hydroxyl and superoxide radicals by stimulated human neutrophils — measurements by EPR spectroscopy (1979) (142)
Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis. (2007) (138)
The NADPH oxidase and chronic granulomatous disease. (1996) (134)
Chronic granulomatous disease (1991) (134)
NADPH oxidase and the respiratory burst. (1995) (131)
A structural model for the nucleotide binding domains of the flavocytochrome b–245 β‐chain (1993) (125)
Autosomal recessive chronic granulomatous disease caused by deletion at a dinucleotide repeat. (1991) (123)
The subcellular distribution and some properties of the cytochrome b component of the microbicidal oxidase system of human neutrophils. (1979) (120)
Elemental diets in treatment of acute Crohn's disease. (1980) (119)
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease (2009) (118)
Nitroblue-tetrazolium tests. (1974) (117)
A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm. (1997) (114)
The function of the NADPH oxidase of phagocytes and its relationship to other NOXs in plants, invertebrates, and mammals (2008) (113)
Cytochrome b-245 of neutrophils is also present in human monocytes, macrophages and eosinophils. (1981) (112)
Reassessment of the microbicidal activity of reactive oxygen species and hypochlorous acid with reference to the phagocytic vacuole of the neutrophil granulocyte. (2003) (110)
Analysis of glycosylation sites on gp91phox, the flavocytochrome of the NADPH oxidase, by site-directed mutagenesis and translation in vitro. (1997) (105)
Cytochrome b-245 from human neutrophils is a glycoprotein. (1985) (99)
Ym1 Is a Neutrophil Granule Protein That Crystallizes in p47 phox -deficient Mice* (2002) (99)
The NADPH Oxidase of Phagocytic Leukocytes a (1997) (99)
Absence of cytochrome b reduction in stimulated neutrophils from both female and male patients with chronic granulomatous disease (1980) (98)
Crohn’s Disease: an Immune Deficiency State (2010) (96)
The immunopathogenesis of Crohn's disease: a three-stage model. (2009) (96)
Signals to Move Cells (2000) (96)
Clinical features of Candidiasis in patients with inherited interleukin 12 receptor β1 deficiency. (2014) (96)
Localization of the 47 kDa phosphoprotein involved in the respiratory-burst NADPH oxidase of phagocytic cells. (1989) (96)
Kinetics of oxygen consumption by phagocytosing human neutrophils. (1978) (95)
INDIUM-111 TAGGED LEUCOCYTES IN THE DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE (1981) (92)
Direct interaction between p47phox and protein kinase C: evidence for targeting of protein kinase C by p47phox in neutrophils. (1999) (89)
Interactions between cytosolic components of the NADPH oxidase: p40phox interacts with both p67phox and p47phox. (1996) (87)
Further evidence for the involvement of a phosphoprotein in the respiratory burst oxidase of human neutrophils. (1986) (85)
The association of FAD with the cytochrome b-245 of human neutrophils. (1982) (85)
Alpha-enolase: a novel cytosolic autoantigen in ANCA positive vasculitis. (1993) (84)
The Human Salivary Microbiome Is Shaped by Shared Environment Rather than Genetics: Evidence from a Large Family of Closely Related Individuals (2017) (84)
The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain. (2001) (83)
Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoic acid (1990) (83)
Cryptic Rac-binding and p21 Cdc42HS/Rac -activated Kinase Phosphorylation Sites of NADPH Oxidase Component p67 phox * (1998) (83)
Activation of the neutrophil NADPH oxidase is inhibited by SB 203580, a specific inhibitor of SAPK2/p38. (1999) (80)
Indium-111 labeling of leukocytes: a detrimental effect on neutrophil and lymphocyte function and an improved method of cell labelling (1978) (77)
G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction. (2011) (77)
A 68-kDa Kinase and NADPH Oxidase Component p67 Are Targets for Cdc42Hs and Rac1 in Neutrophils (*) (1995) (72)
Identification of cofilin, coronin, Rac and capZ in actin tails using a Listeria affinity approach. (1998) (71)
Reduction and subsequent oxidation of a cytochrome b of human neutrophils after stimulation with phorbol myristate acetate. (1979) (69)
Cantharidin blisters: a technique for investigating leukocyte trafficking and cytokine production at sites of inflammation in humans. (2001) (68)
Purification of cytochrome b-245 from human neutrophils. (1984) (67)
Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity (2015) (67)
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population (2016) (64)
Phagocyte dysfunction and inflammatory bowel disease. (2008) (63)
Impaired neutrophil chemotaxis in Crohn's disease relates to reduced production of chemokines and can be augmented by granulocyte‐colony stimulating factor (2006) (62)
Catalase negative Staphylococcus aureus retain virulence in mouse model of chronic granulomatous disease (2002) (60)
Protein kinase C-delta C2-like domain is a binding site for actin and enables actin redistribution in neutrophils. (2001) (58)
Restoration of superoxide generation to a chronic granulomatous disease-derived B-cell line by retrovirus mediated gene transfer. (1992) (57)
Development of cytochrome b and an active oxidase system in association with maturation of a human promyelocytic (HL-60) cell line (1982) (57)
Preliminary evidence for gut involvement in the pathogenesis of rheumatoid arthritis? (1986) (55)
Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes. (1992) (54)
Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients (2014) (54)
Importance of the site of endoscopic gastric biopsy in ulcerating lesions of the stomach. (1975) (52)
LEVAMISOLE IN THE TREATMENT OF CROHN'S DISEASE (1977) (51)
Genetic Complexity of Crohn’s Disease in Two Large Ashkenazi Jewish Families (2016) (51)
Immunoelectron microscopy shows a clustered distribution of NADPH oxidase components in the human neutrophil plasma membrane (1997) (49)
Changes in the subcellular distribution of the cytochrome b-245 on stimulation of human neutrophils. (1984) (49)
A variant form of X‐linked chronic granulomatous disease with normal nitroblue tetrazolium slide test and cytochrome b (1983) (49)
Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis (2015) (48)
Phosphorylation of the subunits of cytochrome b-245 upon triggering of the respiratory burst of human neutrophils and macrophages. (1988) (48)
A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF. (2016) (47)
Stoichiometry of the subunits of flavocytochrome b558 of the NADPH oxidase of phagocytes. (1996) (46)
The major phosphorylation site of the NADPH oxidase component p67phox is Thr233. (1999) (45)
Protein kinase C-β contributes to NADPH oxidase activation in neutrophils (45)
Rapid incorporation of the human neutrophil plasma membrane cytochrome b into phagocytic vacuoles. (1980) (42)
Identification of the haem-binding subunit of cytochrome b-245. (1989) (42)
Lipidomic profiling in Crohn's disease: Abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition (2012) (42)
The mechanism of the entry of dye into neutrophils in the nitroblue tetrazolium (NBT) test. (1973) (42)
The molecular and cellular pathology of Chronic Granulomatous Disease (1988) (41)
PCR amplification of microdissected wheat chromosome arms in a simple 'single tube' reaction. (1993) (40)
Identification of the defective NADPH‐oxidase component in Chronic Granulomatous Disease: a study of 57 European families (1992) (39)
Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils. (1992) (39)
Killing of pathogens associated with chronic granulomatous disease by the non-oxidative microbicidal mechanisms of human neutrophils. (1991) (39)
Molecular analysis in three cases of X91- variant chronic granulomatous disease. (1995) (38)
N-Formyl peptide receptor subtypes in human neutrophils activate L-plastin phosphorylation through different signal transduction intermediates. (2004) (38)
The bactericidal effects of the respiratory burst and the myeloperoxidase system isolated in neutrophil cytoplasts. (1988) (37)
Re-evaluation of nitroblue-tetrazolium test. (1973) (36)
VARIATIONS ON THE THEME OF CHRONIC GRANULOMATOUS DISEASE (1985) (36)
Okadaic acid produces changes in phosphorylation and translocation of proteins and in intracellular calcium in human neutrophils. Relationship with the activation of the NADPH oxidase by different stimuli. (1992) (36)
Production of superoxide by neutrophils: a reappraisal (1979) (35)
Perspectives: signal transduction. Signals to move cells. (2000) (35)
How superoxide production by neutrophil leukocytes kills microbes. (2006) (35)
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens (2018) (34)
Crohn’s disease as an immunodeficiency (2010) (33)
NADPH oxidases as electrochemical generators to produce ion fluxes and turgor in fungi, plants and humans (2016) (32)
The management of chronic granulomatous disease (1993) (32)
Purification of the 47 kDa phosphoprotein associated with the NADPH oxidase of human neutrophils. (1990) (31)
Halothane does not inhibit human neutrophil function in vitro. (1979) (31)
Critical Role of the Disintegrin Metalloprotease ADAM-like Decysin-1 [ADAMDEC1] for Intestinal Immunity and Inflammation (2016) (30)
Studies of cyanide binding to myeloperoxidase by electron paramagnetic resonance and magnetic circular dichroism spectroscopies (1982) (30)
Phosphorylation of p67 phox in the neutrophil occurs in the cytosol and is independent of p47 phox (1999) (30)
Incidence and prevalence of inflammatory bowel disease in UK primary care: a population-based cohort study (2020) (30)
The function of the NADPH oxidase of phagocytes, and its relationship to other NOXs. (2007) (29)
The subcellular localization of ubiquinone in human neutrophils. (1983) (29)
Subproteome analysis of the neutrophil cytoskeleton (2009) (29)
Characterization of Expression Quantitative Trait Loci in the Human Colon (2015) (28)
Defective tumor necrosis factor release from Crohn's disease macrophages in response to toll-like receptor activation: Relationship to phenotype and genome-wide association susceptibility loci (2012) (28)
Delayed Resolution of Acute Inflammation in Ulcerative Colitis Is Associated with Elevated Cytokine Release Downstream of TLR4 (2010) (28)
Painless ascites in systemic lupus erythematosus. (1977) (27)
Mucosal Transcriptomics Implicates Under Expression of BRINP3 in the Pathogenesis of Ulcerative Colitis (2014) (27)
What Is Wrong with Granulocytes in Inflammatory Bowel Diseases? (2013) (26)
Evidence that neutrophil elastase-deficient mice are resistant to bleomycin-induced fibrosis. (2001) (25)
Investigations of host defence in patients with sickle cell disease (1985) (25)
PX domain takes shape (2003) (25)
Impaired macrophage function following bacterial stimulation in chronic granulomatous disease (2009) (24)
The large-conductance Ca2+-activated K+ channel is essential for innate immunity (2010) (24)
Diminished Macrophage Apoptosis and Reactive Oxygen Species Generation after Phorbol Ester Stimulation in Crohn's Disease (2009) (24)
Effect of high-dose methylprednisolone therapy on phagocyte function in systemic lupus erythematosus. (1984) (24)
The role of grancalcin in adhesion of neutrophils. (2006) (21)
Hypersecretion of glucagon and gastrin in severely burnt patients. (1975) (21)
Subcellular localisation of the p40phox component of NADPH oxidase involves direct interactions between the Phox homology domain and F-actin (2010) (21)
Cell damage and dye reduction in the quantitative nitroblue tetrazolium (NBT) test. (1975) (21)
Variations in the Phagosomal Environment of Human Neutrophils and Mononuclear Phagocyte Subsets (2018) (20)
Granulocyte Function in Grancalcin-Deficient Mice (2003) (20)
The antimicrobial role of the neutrophil leukocyte. (1981) (19)
Phenotypic heterogeneity and evidence of a founder effect associated with G6PC3 mutations in patients with severe congenital neutropenia (2012) (19)
The NADPH Oxidase and Microbial Killing by Neutrophils, With a Particular Emphasis on the Proposed Antimicrobial Role of Myeloperoxidase within the Phagocytic Vacuole. (2016) (19)
The role of neutrophils in the pathogenesis of Crohn's disease (2018) (19)
Can unresolved infection precipitate autoimmune disease? (2006) (19)
Gene transfer to primary chronic granulomatous disease monocytes (1995) (19)
Diagnosis of gastric cancer. (1975) (19)
Functional reconstitution of the NADPH-oxidase by adeno-associated virus gene transfer. (1995) (18)
Reconstitution of NeutroDhil NADPH Oxidase ActivitG in the Cell-free Svstem bv Four Components: p67-phox, p47-phox, (1992) (18)
Making sense of the cause of Crohn’s – a new look at an old disease (2016) (18)
Deficiency of p67phox, p47phox or gp91phox in chronic granulomatous disease does not impair leucocyte chemotaxis or motility (1997) (17)
Factors influencing the entry of dye into neutrophil leucocytes in the Nitroblue Tetrazolium test. (1975) (17)
An exuberant inflammatory response to E coli: implications for the pathogenesis of ulcerative colitis and pyoderma gangrenosum (2006) (17)
Studies on patients establish Crohn's disease as a manifestation of impaired innate immunity (2019) (16)
Involvement of protein kinase D in Fc gamma-receptor activation of the NADPH oxidase in neutrophils. (2002) (16)
Cytochrome b-245 and its involvement in the molecular pathology of chronic granulomatous disease. (1988) (16)
Elemental diets in treatment of acute Crohn's disease (1981) (15)
An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of Neutrophils (2017) (15)
Oxygen consumption by stimulated human neutrophils. (1978) (14)
Levamisole-induced arthritis in Crohn's disease. (1977) (13)
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility (2022) (13)
Generation of recombinant adeno-associated virus (rAAV) from an adenoviral vector and functional reconstitution of the NADPH-oxidase. (1995) (13)
Components and Organisation of the NADPH Oxidase of Phagocytic Cells, the Paradigm for an Electron Transport Chain across the Plasma Membrane (1998) (13)
How do phagocytic cells kill bacteria? (1984) (13)
The Neutrophil Respiratory Burst and Bacterial Digestion in Crohn’s Disease (2011) (13)
NEUTROPHIL CYTOCHROME b IN CHRONIC GRANULOMATOUS DISEASE (1979) (13)
Modified skin window technique for the extended characterisation of acute inflammation in humans (2007) (13)
Characterization and partial purification of a novel neutrophil membrane-associated kinase capable of phosphorylating the respiratory burst component p47phox. (1999) (13)
The use of nitroblue tetrazolium prestaining of serum lipoproteins on polyacrylamide disc electrophoresis. (1974) (11)
CO binding and ligand discrimination in human myeloperoxidase. (2010) (11)
[21] Cytochrome b-245 (1986) (11)
The NADPH oxidase of phagocytic cells is an electron pump that alkalinises the phagocytic vacuole (1995) (10)
Defective degradation of bacterial DNA by phagocytes from patients with systemic and discoid lupus erythematosus. (1987) (10)
NADPH oxidase is not essential for low density lipoprotein oxidation by human monocyte-derived macrophages. (1994) (10)
An ELISA for grancalcin, a novel cytosolic calcium-binding protein present in leukocytes. (1995) (10)
Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67phox. (2014) (10)
A New Look at Familial Risk of Inflammatory Bowel Disease in the Ashkenazi Jewish Population (2018) (10)
Structure of the NADPH-oxidase: membrane components. (1993) (10)
The digestion of bacterial macromolecules by phagocytic cells: the effect of mepacrine and ethanol. (1987) (9)
Imaging the Neutrophil Phagosome and Cytoplasm Using a Ratiometric pH Indicator (2017) (9)
Involvement of protein kinase D in Fc γ-receptor activation of the NADPH oxidase in neutrophils (8)
Sequencing of over 100,000 individuals identifies multiple genes and rare variants associated with Crohns disease susceptibility (2021) (8)
Superoxide generation, cytochrome b−245, and chronic granulomatous disease (1984) (8)
The mechanism of the NBT (nitroblue tetrazolium) test. (1973) (8)
Reconstitution of GTPgammaS-induced NADPH oxidase activity in streptolysin-O-permeabilized neutrophils by specific cytosol fractions. (1999) (8)
Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies (2015) (8)
A phagocyte dilemma... (2011) (8)
The kinetic measurement of phagocyte function in whole blood. (1983) (7)
Components of the microbicidal oxidase of phagocytes. (1991) (7)
The LRRC8A Mediated “Swell Activated” Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils (2017) (7)
Reconstitution of cell-free NADPH oxidase activity by purified components. (1995) (7)
Rare coding variant analysis in a large cohort of Ashkenazi Jewish families with inflammatory bowel disease (2018) (7)
ZODET: Software for the Identification, Analysis and Visualisation of Outlier Genes in Microarray Expression Data (2014) (7)
The nature and function of the microbicidal oxidase system of neutrophils. (1981) (7)
Components and organization of the nadph oxidase of phagocytic cells: Its role in microbial killing and in the molecular pathology of chronic granulomatous disease (1999) (7)
The alpha subunit of cytochrome b-245 mapped to chromosome 16. (1990) (6)
Nitroblue tetrazolium--a new lipoprotein stain. (1973) (6)
Elevation in Cell Cycle and Protein Metabolism Gene Transcription in Inactive Colonic Tissue From Icelandic Patients With Ulcerative Colitis (2018) (6)
Testing Neutrophil Function (1976) (6)
Genetic analysis of four consanguineous multiplex families with inflammatory bowel disease (2021) (6)
Respiratory Burst Oxidase of the Neutrophil (1991) (6)
Correction: Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population (2019) (5)
Tracing the fate of oxygen consumed during phagocytosis by human neutrophils with 15O2. (1978) (5)
The human oral microbiome is shaped by shared environment rather than genetics: evidence from a large family of closely-related individuals (2017) (5)
Making sense of the cause of Crohn's - a new look at an old disease. (2016) (5)
Neutrophil and Complement Defects: Recent Advances (1988) (5)
The NADPH oxidase and microbial killing by neutrophils, with a particular emphasis on the proposed antimicrobial role of myeloperoxidase within the phagocytic vacuole (2015) (5)
I ndiu rn-i i 1 La bel in g of Leu kocytes: A Detri menta I Effect on Neutrophil and Lyrnphocyte Function and an improved Method of Cell Labeling (1978) (4)
The electron transport chain of the microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous disease. (1989) (4)
Ulcerative colitis is characterized by amplified acute inflammation with delayed resolution (2019) (4)
Chronic granulomatous disease — biochemistry with special reference to oxygen metabolism (1979) (4)
Shotgun cholanomics of ileal fluid (2012) (4)
Indiumâ€”ill-Labeled Autologous Leukocytes In Man (2006) (4)
Prophylaxis of supraventricular tachycardia. (1971) (3)
Components of the NADPH oxidase of phagocytic cells and their abnormality in the molecular pathology of Chronic Granulomatous Disease (CGD) (1993) (3)
Chronic granulomatous disease: towards gene therapy. (1993) (3)
CLINICAL FEATURES OF CANDIDIASIS IN PATIENTS WITH INTERLEUKIN-12 RECEPTOR B1 DEFICIENCY (2012) (3)
Use of contraceptives and risk of inflammatory bowel disease: a nested case–control study (2021) (3)
Identification of a previously undescribed cytochrome b in human neutrophils and its relationship to phagocytosis-induced oxidase activity [proceedings]. (1979) (3)
Cytochrome b-245. (1986) (3)
Biochemistry and molecular biology of chronic granulomatous disease (1992) (2)
Asymmetric signal transduction (2000) (2)
Early-onset inflammatory bowel disease caused by mutant IL10 receptor (2010) (2)
PTU-032 Differential bacterial clearance and cytokine secretion by macrophages explains localisation of Crohn's disease to the gut (2010) (2)
A polymorph abnormality in Crohn’s disease (1977) (2)
Optineurin deficiency contributes to impaired cytokine secretion and neutrophil recruitment in bacteria driven colitis (2015) (2)
88 The Prevalence of Undiagnosed Disorders of Neutrophil Function Mimicking Crohn's Disease (2008) (2)
Characterization and partial purification of a novel neutrophil membrane-associated kinase capable of phosphorylating the respiratory burst component p 47 phox (1999) (2)
Chronic granulomatous disease. (1994) (2)
Biochemistry and physiology of the neutrophil: by Steven W. Edwards, Cambridge University Press, 1994, £35.00 (xvii + 299 pages) ISBN 0 52141698 1 (1995) (1)
CHAPTER 1 – Composition and Function of the NADPH Oxidase of Phagocytic Cells with Particular Reference to Redox Components Located within the Plasma Membrane (1992) (1)
The HVCN1 channel conducts protons into the phagocytic vacuole of neutrophils to produce a physiologically alkaline pH (2014) (1)
Physiology and pathology of the neutrophil (1979) (1)
Early-onset inflammatory bowel disease caused by loss-of-function mutations in the IL10-receptor genes (2009) (1)
Tu1967 A Gene Expression Outlier Strategy Towards Identifying Molecular Causes of Crohn's Disease (2012) (1)
Corrigendum: An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of Neutrophils (2017) (1)
Letter: Further application of the nitroblue tetrazolium test. (1974) (1)
Seqfam: A python package for analysis of Next Generation Sequencing DNA data in families (2018) (1)
P165 Inflammatory Bowel Disease in CGD Reproduces the Pathological Features of Crohn's Disease (2007) (1)
Sa1791 ADAMDEC1: A Novel Molecule Linked to Crohn's Disease, Is Associated With an Increased Susceptibility to Citrobacter Rodentium Colitis in the Knock out Mouse (2013) (1)
PTH-087 Fam5C, a Possible Causal Molecule in Ulcerative Colitis Revealed through a Transcriptomic Analysis of the Bowel Mucosa (2013) (1)
A simple haemostatic device. (1973) (1)
The HVCN1 channel conducts protons across the phagocytic vacuole of neutrophils (2014) (1)
Studies on two patients with disseminated intracellular mycobacterial infections, one with defective IL-12 p40 production and the other with defective IL-12 receptor signalling. (1998) (1)
Reconstitution of G-protein-activated NADPH oxidase activity with a cytosolic factor in streptolysin O-permeabilized human neutrophils (1998) (1)
DOP014 The role of optineurin in macrophage cytokine secretion and Crohn's disease (2014) (0)
Mo1786 ADAMDEC1: A Novel Molecule in Inflammation and Bowel Disease (2012) (0)
Phagocytic and Bactericidal Defects in Neutrophils (1981) (0)
Assessment of neutrophil NADPH oxidase activity and phagosomal pH and area using the myeloid Hoxb8 cell line with and without HVCN1 (2017) (0)
The molecular basis of autosomal recessive chronic granulomatous disease (1991) (0)
Neutrophil Elastase Participates in TGF-β Activation in Bleomycin-Induced Pulmonary Fibrosis (2002) (0)
Crohn's is an immunodeficiency disease (2010) (0)
5 - Neutrophil accumulation and bacterial clearance are delayed in patients with Crohn's disease (2009) (0)
A novel method to investigate the inflammatory response in the bowel, and confirmation of its impairment in Crohn's disease (2004) (0)
P441 Whole-genome sequencing, haplotype characterisation and transcriptomic analysis in an extended multiplex kindred with 40 individuals affected with inflammatory bowel disease (2012) (0)
BACTERIAL CLEARANCE IS DELAYED IN PATIENTS WITH CROHN'S DISEASE (2009) (0)
The nature and function of the microbicidal oxidase system of neutrophils. (1982) (0)
Enzymes and metabolic activity of phagocytes (1986) (0)
POSTERS Microinjected neutrophils retain the ability to release superoxide (2001) (0)
Severe Early-Onset Inflammatory Bowel Disease Caused by IL10 Receptor Deficiency Can Be Cured by Allogeneic Hematopoietic Stem Cell Transplantation. (2009) (0)
Killing of pathogens associated with chronic granulomatous disease by the non-oxidative mechanisms of human neutrophils microbicidal (1991) (0)
SHORT COMMUNICATION The a! Subunit of Cytochrome b_,,, Mapped to Chromosome 16 (1990) (0)
Neutrophil deficiency during acute inflammation in inflammatory bowel disease (2001) (0)
Crohn’s disease is caused by a failure of the innate immune response with major abnormalities in macrophage biology (2010) (0)
The PKC-d C2-like domain is a binding site for actin and enables PKC-d-induced actin remodelling in neutrophils. (2001) (0)
Failure of the acute inflammatory response in Crohn's disease: The influence of CARD15 (2004) (0)
Studies to identify the causal molecules in Crohn's disease (2010) (0)
S1734 Abnormal TLR4-Mediated Interferon Response in Ulcerative Colitis (2009) (0)
An essential role for BKCa channels in innate immunity (2004) (0)
Experimentally-induced pyoderma gangrenosum (2006) (0)
NOVEL G6PC3 MUTATIONS IDENTIFIED IN AUTOSOMAL RECESSIVE SCN PATIENTS WITH AND WITHOUT CONGENITAL ABNORMALITIES (2009) (0)
ROLE OF JUNCTIONAL ADHESION MOLECULE-A IN MAINTAINING MUCOSAL HOMEOSTASIS IN INFLAMMATORY BOWEL DISEASE A (2008) (0)
5 th European Workshop on Immune-Mediated Inflammatory Diseases (0)
P296 The Neutrophil Respiratory Burst is Preserved in Perianal Crohn's Disease (2008) (0)
Exaggerated Onset and Delayed Resolution of Acute Inflammation in Ulcerative Colitis (2017) (0)
P055 Relationship of impaired macrophage cytokine release to genetic susceptibility polymorphisms in Crohn's disease (2012) (0)
Characterisation of the defect in acute inflammation in Crohn's disease and the influence of CARD15 (2004) (0)
Sa1784 – Inflammatory Bowel Disease in Uk Primary Care: Sociodemographic Trends in Incidence (2019) (0)
Importance ofthesite ofendoscopic gastric biopsy inulcerating lesions ofthestomach (1975) (0)
Impaired acute inflammation in the terminal ileum of Crohn's patients (2005) (0)
DEVELOPMENT OF ADENOASSOCIATED VIRUS VECTORS FOR GENE-THERAPY OF CHRONIC GRANULOMATOUS-DISEASE (1995) (0)
Erratum: (The Journal of Clinical Investigation (March 1997) 99:5) (1998) (0)
Similar distribution of T-cell subsets in Crohn’s disease and in diverticulitis provide evidence against a primary causal role for these cells in Crohn’s (2019) (0)
P043 Ulcerative colitis is characterised by an exaggerated onset of acute inflammation with delayed resolution. (2017) (0)
BTS/BLF Young Investigators Prize Symposium T1 LYMPHOCYTIC BRONCHOALVEOLITIS IN IDIOPATHIC CHRONIC COUGH (2002) (0)
INFLIXIMAB TREATMENT DECREASES SERUM OSTEOPROTEGERIN CONCENTRATION IN PATIENTS WITH CROHN'S DISEASE (2007) (0)
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens (2018) (0)
p47(phax) regulates ''amoebic'' cytoskeleton in neutrophils (1996) (0)
White cell rheology and inflammation Edited by K. Messmer and F. Hammersen Karger, Germany, 1985, 124 pages, $30.25 (1985) (0)
Proceedings: The importance of the site of gastrobiopsy in ulcerating lesions of the stomach. (1974) (0)
P083 ADAMDEC1: a novel molecule linked to Crohn's disease, is associated with an increased susceptibility to Citrobacter rodentium colitis in the knock out mouse (2013) (0)
5-Aminosalicylates Promote Generation of Anti-Inflammatory Hydroxy Fatty Acids that Contribute to Inflammation Resolution in Ulcerative Colitis (2017) (0)
5-aminosalicylate drugs generate anti-inflammatory hydroxy fatty acids that act upon macrophages to promote inflammation resolution in ulcerative colitis (2017) (0)
An Oxidase System in the Plasma Membrane of Phagocytic Leucocytes - Function and Dysfunction (1982) (0)
TGF-beta activation is diminished following bleomycin-induced lung injury in mice lacking neutrophil elastase (2002) (0)
Severe early onset ileo-colitis can be caused by mutations in IL10RB and successfully treated by allogeneic hematopoietic stem cell transplantation (2010) (0)
Novel Human Immunodeficiencies resulting in increased susceptibility to mycobacterial and salmonella infections. (1998) (0)
Evidence against the microbicidal action of neutrophil extracellular traps (NETs) (2018) (0)
1095 Neutrophil Accumulation and Bacterial Clearance Is Delayed in Patients with Crohn's Disease (2009) (0)
Neutrophil respiratory burst and tissue penetration are normal in Crohn's disease during G-CSF administration (2002) (0)
Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies (2015) (0)
Characterization and partial purification of a novel neutrophil membrane- associated kinase capable of phosphorylating the respiratory burst (1999) (0)
Investigating the effect of ion channel inhibitors on respiratory burst activity and pH in the neutrophil phagocytic vacuole (2016) (0)
Transforming Growth Factor-β Activation is Diminished in Fibrosis-Resistant Neutrophil Elastase-Deficient Mice (2003) (0)
Chronic Granulomatous Disease and Other Disorders of Phagocytosis (2001) (0)
P260 The Macrophage Response to E. Coli Demonstrates a Primary Defect in Colonic Crohn's Disease (2008) (0)
P076 A gene expression outlier strategy towards identifying molecular causes of Crohn's disease (2012) (0)
Indium-111 Labelling of Neutrophils and Lymphocytes: Damage to Labelled Cells and an Improved Method of Cell Labelling (1978) (0)
Identification of the major phosphorylation site of the NADPH oxidase component p67phox. (1997) (0)
Rare coding variant analysis in a large cohort of Ashkenazi Jewish families with inflammatory bowel disease (2018) (0)
The respiratory burst oxidase and its physiological significance:edited by Anthony J. Sbarra and Robert R. Strauss, Plenum Press, 1988. $85.00 (xxi + 476 pages) ISBN 0 306 42883 0 (1989) (0)
Molecular medicine. (1990) (0)
Bleomycin-induced pulmonary fibrosis is attenuated in neutrophil elastase-deficient mice (2000) (0)
Genetic Complexity of Crohn ’ s Disease in 2 Large Ashkenazi Jewish Families Short title : The genetics of Crohn ’ s disease in twolarge Ashkenazi Jewish families (2016) (0)
P758 Elevation in ribosomal and cell cycle gene transcription in macroscopically normal colonic tissue from Icelandic patients with ulcerative colitis. (2017) (0)
Book ReviewDextrans: Current concepts of basic actions and clinical applications. (1972) (0)
P248 Attenuated TNF-α Release following Toll-Like Receptor Stimulation of Macrophages in Crohn's Disease (2008) (0)
Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients (2023) (0)
P045 5-Aminosalicylates promote inflammation resolution in ulcerative colitis through generation of anti-inflammatory hydroxy fatty acids. (2017) (0)
Thedigestion ofbacterial macromolecules byphagocytic cells: theeffect ofmepacrine andethanol (1987) (0)
Use of il-8 for the treatment of crohn' s disease (2007) (0)
P073 ADAMDEC1: A novel molecule in inflammation and bowel disease (2012) (0)
Differences in micro-vascular blood flow at sites of skin blistering may account for reduced leukocyte trafficking in Crohn's disease (2002) (0)
ioche istry an Molecular iology of Chronic Granulo atous Disease (1992) (0)
Neutrophil respiratory burst and tissue penetration are normal in CD during G-CSF administration (2002) (0)
The microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous disease. (1988) (0)
99 – Inflammatory Bowel Disease in Uk Primary Care: Temporal Trends in Epidemiology During the Early 21ST Century (2019) (0)
The structure of rho-GDI and its interaction with the small GTPase RAC (1997) (0)
disease- derived B-cell line by retrovirus mediated gene transfer Restoration of superoxide generation to a chronic granulomatous (2011) (0)
OC-019 Adamdec1: A Novel Molecule Linked to Crohn’S Disease, is Associated with an Increased Susceptibility to Citrobacter Rodentium Colitis in the knock out Mouse (2013) (0)
Alveolar-capillary leak is attenuated in neutrophil elastase 'knockout' mice with bleomycin-induced lung injury (2001) (0)
PTU-130 Mucosal MRNA expression profiling from the terminal ileum and colon reveals under expression of claudin 8, a tight junction molecule, as potentially causal in ulcerative colitis (2012) (0)
T1235 Subcutaneous Injection of E. coli in Human Subjects Demonstrates Excessive Acute Inflammation and Delayed Resolution in Ulcerative Colitis (2008) (0)

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