Nancy Andrews
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American physician and biologist
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Nancy Andrews philosophy Degrees
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Biology Philosophy
Nancy Andrews 's Degrees
- Doctorate Medicine Harvard University
Why Is Nancy Andrews Influential?
(Suggest an Edit or Addition)According to Wikipedia, Nancy C. Andrews NAS is an American biologist and physician noted for her research on iron homeostasis. Andrews was formerly Dean of the Duke University School of Medicine. Biography Andrews grew up in Syracuse, New York. She earned a B.S. and M.S. from Yale University. She carried out her M.S. research with Joan Steitz at Yale University, studying molecular biophysics and biochemistry, and continued her graduate work with David Baltimore, earning an M.D.-Ph.D. at Harvard Medical School and M.I.T. . She completed her postdoctoral work with Stuart Orkin at Children's Hospital Boston.
Nancy Andrews 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. (1991) (2470)
- p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. (1998) (2209)
- Balancing Acts Molecular Control of Mammalian Iron Metabolism (2004) (1663)
- Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter (2000) (1580)
- Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene (1997) (1112)
- The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. (2005) (1027)
- Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression (2006) (1012)
- Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization (2004) (982)
- Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. (1998) (945)
- Interleukin-6 induces hepcidin expression through STAT3. (2006) (846)
- Disorders of iron metabolism. (1999) (644)
- Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. (2002) (643)
- Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA) (2008) (634)
- Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein (1993) (622)
- Forging a field: the golden age of iron biology. (2008) (592)
- Iron homeostasis. (2007) (569)
- Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. (2001) (565)
- Transferrin receptor is necessary for development of erythrocytes and the nervous system (1999) (556)
- Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus. (1981) (516)
- Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. (2007) (446)
- Iron homeostasis: insights from genetics and animal models (2000) (391)
- Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Altering Mg2+ Homeostasis (2008) (378)
- Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. (2005) (376)
- Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses (2007) (374)
- Hereditary Hemochromatosis Protein, HFE, Interaction with Transferrin Receptor 2 Suggests a Molecular Mechanism for Mammalian Iron Sensing* (2006) (359)
- Anemia of inflammation: the cytokine-hepcidin link. (2004) (359)
- A mouse model of juvenile hemochromatosis. (2005) (351)
- The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. (2008) (330)
- Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. (2006) (319)
- Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis (2003) (318)
- Iron‐dependent regulation of the divalent metal ion transporter (2001) (305)
- Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis (2003) (301)
- The Maf transcription factors: regulators of differentiation. (1997) (267)
- Scara5 is a ferritin receptor mediating non-transferrin iron delivery. (2009) (264)
- The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. (1999) (259)
- TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation (2010) (255)
- Comparison of the Interactions of Transferrin Receptor and Transferrin Receptor 2 with Transferrin and the Hereditary Hemochromatosis Protein HFE* (2000) (248)
- The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. (1993) (245)
- The iron transporter DMT1. (1999) (233)
- Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. (2010) (224)
- The G185R mutation disrupts function of the iron transporter Nramp2. (1998) (223)
- Genes that modify the hemochromatosis phenotype in mice. (2000) (217)
- Proinflammatory state, hepcidin, and anemia in older persons. (2010) (207)
- Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart. (2015) (207)
- Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. (2007) (197)
- Anemia of inflammation: the hepcidin link (2005) (189)
- Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. (2005) (180)
- The molecular defect in hypotransferrinemic mice. (2000) (180)
- Iron metabolism: iron deficiency and iron overload. (2000) (178)
- Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner (1993) (175)
- Iron is essential for neuron development and memory function in mouse hippocampus. (2009) (159)
- A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency (2015) (158)
- Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. (2010) (152)
- The channel kinase, TRPM7, is required for early embryonic development (2011) (149)
- Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin. (2003) (149)
- Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI. (2002) (148)
- Iron and copper in mitochondrial diseases. (2013) (133)
- Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouse (2003) (132)
- Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. (2012) (125)
- An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice (2004) (118)
- Molecular control of iron metabolism. (2005) (111)
- The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2 (1997) (107)
- The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. (2000) (104)
- Metal transporters and disease. (2002) (103)
- The ins and outs of iron homeostasis. (2006) (99)
- Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. (2008) (98)
- Transferrin receptor 1 is differentially required in lymphocyte development. (2003) (98)
- A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice (2005) (95)
- Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice. (2006) (94)
- Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. (2001) (93)
- Recent advances in disorders of iron metabolism: mutations, mechanisms and modifiers. (2001) (93)
- Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the Nrf3 Locus (2004) (90)
- Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice (2016) (89)
- A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. (2001) (88)
- Iron transport across biologic membranes. (2009) (85)
- The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. (2007) (85)
- Molecules in focus The NF-E2 transcription factor (1998) (84)
- Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. (2011) (84)
- Regulation of iron absorption in Hfe mutant mice. (2002) (84)
- In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction (1992) (84)
- Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. (1997) (83)
- p45 NF‐E2 regulates expression of thromboxane synthase in megakaryocytes (1997) (83)
- The other physician-scientist problem: Where have all the young girls gone? (2002) (80)
- Positive and negative elements regulate human interleukin 3 expression. (1990) (76)
- Purification of a terminal uridylyltransferase that acts as host factor in the in vitro poliovirus replicase reaction. (1986) (70)
- Iron homeostasis and erythropoiesis. (2008) (65)
- A Spontaneous, Recurrent Mutation in Divalent Metal Transporter-1 Exposes a Calcium Entry Pathway (2004) (64)
- Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice (2007) (63)
- The NF-E2 transcription factor. (1998) (62)
- Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice. (2009) (61)
- Poliovirus replicase stimulation by terminal uridylyl transferase. (1985) (60)
- Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis (2015) (60)
- A mouse model of familial porphyria cutanea tarda. (2001) (59)
- 2002 E. Mead Johnson Award for Research in Pediatrics Lecture: The Molecular Biology of the Anemia of Chronic Disease: A Hypothesis (2003) (58)
- Iron homeostasis and inherited iron overload disorders: an overview. (2004) (57)
- Identification of a novel mutation (C321X) in HJV. (2004) (56)
- Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle (2015) (55)
- Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis. (2011) (54)
- Transferrin is required for early T‐cell differentiation (2004) (54)
- Understanding heme transport. (2005) (53)
- Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice. (2004) (51)
- Climbing through medicine's glass ceiling. (2007) (51)
- Iron is hot: an update on the pathophysiology of hemochromatosis. (1998) (50)
- Iron Is Hot: An Update on the Pathophysiology of Hemochromatosis (1998) (48)
- The molecular regulation of iron metabolism. (2004) (46)
- A genetic view of iron homeostasis. (2002) (46)
- Mammalian iron transport: an unexpected link between metal homeostasis and host defense. (1998) (45)
- The G 185 R Mutation Disrupts Function of the Iron Transporter Nramp 2 (1998) (44)
- Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2 (1993) (44)
- Late stage erythroid precursor production is impaired in mice with chronic inflammation (2012) (43)
- Intestinal iron absorption: current concepts circa 2000. (2000) (39)
- Haptoglobin modifies the hemochromatosis phenotype in mice. (2005) (38)
- Genes determining blood cell traits (2009) (36)
- Inherited iron overload disorders. (2000) (35)
- Molecular insights into mechanisms of iron transport. (1999) (34)
- Closing the iron gate. (2012) (33)
- When is a heme transporter not a heme transporter? When it's a folate transporter. (2007) (33)
- Mining copper transport genes (2001) (31)
- Enhanced expression of interleukin-3 and granulocyte-macrophage colony-stimulating factor receptor subunits in murine hematopoietic cells stimulated with hematopoietic growth factors. (1992) (30)
- Contributions of β2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1 −/− and β2mRag1 −/− double knock-out mice (2004) (29)
- Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin. (2010) (28)
- Iron in skin of mice with three etiologies of systemic iron overload. (2005) (22)
- cAMP-dependent Protein Kinase Is Necessary for Increased NF-E2DNA Complex Formation during Erythroleukemia Cell Differentiation (*) (1995) (22)
- Novel bacterial P-type ATPases with histidine-rich heavy-metal-associated sequences. (1994) (21)
- Transcriptional control of erythropoiesis. (1994) (20)
- Mutation of Rubie, a Novel Long Non-Coding RNA Located Upstream of Bmp4, Causes Vestibular Malformation in Mice (2012) (20)
- Deficiency of heme-regulated eIF2α kinase decreases hepcidin expression and splenic iron in HFE−/− mice (2008) (19)
- Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice. (2001) (18)
- Phage T3 DNA contains an exact copy of the 23 base-pair phage T7 RNA polymerase promoter sequence. (1981) (18)
- Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice. (2004) (17)
- Uroporphyria in Hfe mutant mice given 5‐aminolevulinate: A new model of Fe‐mediated porphyria cutanea tarda (2001) (17)
- Probing the iron pool. Focus on "Detection of intracellular iron by its regulatory effect". (2004) (17)
- Ectopic Expression of Transcription Factor NF-E2 Alters the Phenotype of Erythroid and Monoblastoid Cells* (2000) (17)
- Ferrit(in)ing out new mechanisms in iron homeostasis. (2010) (16)
- Structure and regulation of the chicken erythroid δ-aminolevulinate synthase gene (1994) (15)
- A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase. (2007) (15)
- Multiple Proteins Interact with the Nuclear Inhibitory Protein Repressor Element in the Human Interleukin-3 Promoter (*) (1995) (14)
- Lack of evidence for VPg priming of poliovirus RNA synthesis in the host factor-dependent in vitro replicase reaction (1986) (14)
- Iron deficiency: lessons from anemic mice. (1997) (14)
- Erythroid Transcription Factor NF-E2 Coordinates Hemoglobin Synthesis (1994) (13)
- Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2 (1994) (13)
- Increased Hepcidin Expression in Mice Affected by β-Thalassemia Reduces Iron Overload with No Effect on Anemia (2008) (12)
- Animal models of hereditary iron transport disorders. (2002) (11)
- A Woman's Education (2002) (11)
- Iron and erythropoiesis. (1969) (11)
- Molecular characterization and localization of the human MAFG gene. (1997) (11)
- Hemojuvelin Acts as a Bone Morphogenetic Protein Co-Receptor To Regulate Hepcidin Expression. (2005) (10)
- Control of Systemic Iron Homeostasis by the 3’ Iron-Responsive Element of Divalent Metal Transporter 1 in Mice (2020) (9)
- Analysis of the E399D mutation in SLC11A2. (2005) (9)
- ABCs of erythroid mitochondrial iron uptake (2009) (9)
- Iron metabolism and absorption (2000) (7)
- Iron Deficiency Anemia Associated with an Error of Iron Metabolism in Two Siblings: A Thirty Year Follow Up. (1996) (6)
- Tmprss6, An Inhibitor of Hepatic Bmp/Smad Signaling, Is Required for Hepcidin Suppression and Iron Loading In a Mouse Model of β-Thalassemia (2010) (6)
- Hepcidin Expression Is Regulated by a Complex of Hemochromatosis-Associated Proteins. (2006) (6)
- Evidence generation and reproducibility in cell and gene therapy research: A call to action (2021) (6)
- Case records of the Massachusetts General Hospital. Case 21-2005. A four-week-old male infant with jaundice and thrombocytopenia. (2005) (6)
- Can we keep the "academic" in academic medicine? 2009 American Society for Clinical Investigation Presidential Address. (2010) (6)
- Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2. (1995) (5)
- Hematopoietic-specific Stat 5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression ┼ (2008) (5)
- Iron metabolism in mice with partial frataxin deficiency (2008) (5)
- Red Cells Cybrd 1 ( duodenal cytochrome b ) is not necessary for dietary iron absorption in mice Running Head : Targeted disruption of Cybrd 1 (2005) (4)
- Erythroid AP-1/NF-E2 elements vary in their response to NF-E2. (1996) (4)
- Women: diversity among leaders is there if you look. (2010) (3)
- Hungry irony. (2015) (3)
- Commentary on: ferrokinetics in the syndrome of familial hypoferremic microcytic anemia with iron malabsorption. (1999) (3)
- Animal Models of Iron Transport and Storage Disorders (2002) (3)
- Iron Metabolism in the Mice with Targeted Mutations of the DMT1 Gene . (2004) (3)
- Women: diversity among leaders is there if you look (2010) (2)
- InVivoFootprinting oftheHumano-Globin LocusUpstream Regulatory Element byGuanine andAdenineLigation- Mediated Polymerase ChainReaction (1992) (2)
- Structure and regulation of the chicken erythroid delta-aminolevulinate synthase gene. (1994) (2)
- Hepcidin as a Therapeutic Tool to Limit Iron Overload and Improve Anemia In β-Thalassemia (2010) (2)
- IRON AND ERYTHROPOIESIS Lessons from Anemic Mice (1999) (2)
- Forging iron links (2003) (1)
- Role of Adventitia in Pulmonary Vascular Remodeling (2006) (1)
- RENAL HANDLING OF IRON IN MOUSE MODELS OF IRON OVERLOAD: RECENT CONCEPT (2011) (1)
- Build it and hope that enough of them will come. (2009) (1)
- Family: A Portrait of Gay and Lesbian America (1994) (1)
- Ferreting out the dynamics of ferritin expression (2001) (1)
- An iron-clad role for proteasomal degradation. (2011) (1)
- Pathophysiologic mechanisms of anemia of chronic disease. (2004) (1)
- A Mutation in Sec15l1 Disrupts the Transferrin Cycle and Causes Anemia in Hemoglobin Deficit (hbd) Mice. (2005) (1)
- Tea with Juan Quezada: An Afternoon at Rancho Barro Blanco (2012) (0)
- Nramp2 Transports Ferrous Iron, and is Defective in mk Mice and b Rats • 800 (1998) (0)
- changes in iron metabolism induced by doxorubicin Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates (2013) (0)
- Interleukin-6 induces hepcidin expression through STAT3. Commentary (2006) (0)
- anemia associated with reduced transferrin receptor gene expression Hematopoietic-specific Stat5-null mice display microcytic hypochromic (2013) (0)
- The science of climbing the academic ladder. Interview by Barbara Kantrowitz and Holly Peterson. (2008) (0)
- Purification and expression of an Abelson-murine-leukaemia-virus-encoded protein kinase from Escherichia coli (1984) (0)
- anemia: implications for the anemia of chronic disease Inappropriate expression of hepcidin is associated with iron refractory (2013) (0)
- Of mice and iron: ferroportin disease (2007) (0)
- p 45 NF-E 2 regulates expression of thromboxane synthase in megakaryocytes 1991 (2013) (0)
- Regulation of the human interleukin-3 gene. (1989) (0)
- Brief report Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice (2004) (0)
- The mother of all careers (2009) (0)
- Genetic Loss of Tmprss6 Increases Effective Erythropoiesis in a Mouse Model of β-Thalassemia (2012) (0)
- Response : Cybrd 1 is not essential in mice (0)
- The molecular basis of iron metabolism (2019) (0)
- Women in metabolism: part I. (2015) (0)
- The Iron Exporter Ferroportin Plays A Role in Retinal Iron Homeostasis (2006) (0)
- P0726 IMPAIRED INTESTINAL IRON ABSORPTION IN CROHN???S DISEASE CORRELATES WITH DISEASE ACTIVITY AND INFLAMMATORY CYTOKINES (2004) (0)
- Nutrient-Gene Expression Expression of Stimulator of Fe Transport Is Not Enhanced in Hfe Knockout Mice 1 , 2 (2001) (0)
- Iron Metabolism: Disorders (2006) (0)
- cells stimulated with hematopoietic growth factors colony- stimulating factor receptor subunits in murine hematopoietic Enhanced expression of interleukin-3 and granulocyte-macrophage (2013) (0)
- CHAPTER 78 – Iron Absorption (2006) (0)
- Inhibited Maturation of Ter119+CD71+ Erythroid Precursors in Mice with Chronic Sterile Abscess. (2008) (0)
- The Serine Protease Tmprss6 Regulates Hepcidin Expression, but Its Loss Does Not Cause Systemic Iron Deficiency In the Fetal and Neonatal Periods (2010) (0)
- Abstract 18964: Resveratrol Prevents Iron-overload Cardiomyopathy by up Regulating Serca2a and by Exerting Anti-oxidant Effects (2014) (0)
- Purification oftheHumanNF-E2Complex: cDNA Cloning of theHematopoietic Cell-Specific Subunit andEvidence foran Associated Partner (1993) (0)
- Hereditaryhemochromatosisisaniron-overloaddisorderresultingfrommutationsinproteinspresumedto beinvolvedinthemaintenanceofironhomeostasis.Mutationsinhemojuvelin(HJV)causesevere,early-onset juvenilehemochromatosis.ThenormalfunctionofHJVisunknown.Juvenilehemochromatosispatientshave decreasedurinaryleve (2005) (0)
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