Bart De Strooper

Q: What Schools Are Affiliated With Bart De Strooper

Bart De Strooper is affiliated with the following schools: University College London, University of Tokyo, KU Leuven, Radboud University Nijmegen

Bart De Strooper's AcademicInfluence.com Rankings

Bart De Strooper

Biology

#1263

World Rank

#2144

Historical Rank

Molecular Biology

#135

World Rank

#139

Historical Rank

biology Degrees

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Biology

Why Is Bart De Strooper Influential?

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According to Wikipedia, Bart De Strooper is a Belgian molecular biologist and professor at Vlaams Instituut voor Biotechnologie and KU Leuven and the UK Dementia Research Institute and University College London, UK. De Strooper's research seeks to translate genetic data into the identification and tratment of neurodegenerative diseases and treatments. interest are the secretases, proteases which cleave the amyloid precursor protein , resulting in amyloid peptides.

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Bart De Strooper's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain (1999) (2078)
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics (2011) (1843)
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein (1998) (1815)
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes (2012) (1692)
OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion (2006) (1445)
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. (1998) (1194)
The Cellular Phase of Alzheimer’s Disease (2016) (1117)
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression (2008) (1079)
Alzheimer's disease (2016) (1006)
Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex (2003) (856)
Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling (2006) (715)
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. (2002) (710)
The secretases: enzymes with therapeutic potential in Alzheimer disease (2010) (701)
Reactive astrocyte nomenclature, definitions, and future directions (2021) (698)
Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations (2006) (651)
Proteolytic processing and cell biological functions of the amyloid precursor protein. (2000) (633)
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. (2005) (618)
Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis (1998) (530)
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. (1999) (524)
ADAM10 cleavage of N‐cadherin and regulation of cell–cell adhesion and β‐catenin nuclear signalling (2005) (484)
APP mouse models for Alzheimer's disease preclinical studies (2017) (448)
Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease (2011) (434)
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. (2003) (434)
Melanoma addiction to the long non-coding RNA SAMMSON (2016) (434)
Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms (2006) (433)
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio (2010) (431)
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease (2012) (423)
Alterations of the microRNA network cause neurodegenerative disease (2009) (417)
The presenilins in Alzheimer's disease--proteolysis holds the key. (1999) (416)
Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease. (2012) (399)
Alteration of the microRNA network during the progression of Alzheimer's disease (2013) (394)
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function (2009) (393)
Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis (2008) (384)
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression (2009) (382)
The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques (2019) (366)
Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice* (2005) (355)
The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex (2010) (350)
Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells (2000) (343)
Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin (2005) (340)
Neuronal membrane cholesterol loss enhances amyloid peptide generation (2004) (328)
Lipids revert inert Aβ amyloid fibrils to neurotoxic protofibrils that affect learning in mice (2007) (324)
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease (2020) (320)
Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons (1999) (317)
LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis (2012) (317)
Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease. (2007) (314)
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein. (2001) (313)
Cell–matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation (2004) (305)
PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling (2014) (296)
Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins* (1997) (296)
Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. (2010) (295)
The amyloid cascade hypothesis: are we poised for success or failure? (2016) (294)
Vitamin K2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency (2012) (290)
Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis (2018) (288)
The Cell Adhesion Protein P-selectin Glycoprotein Ligand-1 Is a Substrate for the Aspartyl Protease BACE1* (2003) (284)
β Subunits of Voltage-gated Sodium Channels Are Novel Substrates of β-Site Amyloid Precursor Protein-cleaving Enzyme (BACE1) and γ-Secretase* (2005) (275)
Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process. (2010) (268)
The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy (2014) (262)
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process (2010) (260)
Novel research horizons for presenilins and γ-secretases in cell biology and disease. (2010) (257)
The role of G protein-coupled receptors in the pathology of Alzheimer's disease (2011) (255)
A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP (2002) (249)
Tau association with synaptic vesicles causes presynaptic dysfunction (2017) (245)
The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture (2001) (243)
The amyloid‐β precursor protein: integrating structure with biological function (2005) (240)
γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease (2009) (230)
Non-coding RNAs with essential roles in neurodegenerative disorders (2012) (229)
Parkin Interacts with Ambra1 to Induce Mitophagy (2011) (226)
A cell biological perspective on Alzheimer's disease. (2002) (224)
Presenilin Couples the Paired Phosphorylation of β-Catenin Independent of Axin Implications for β-Catenin Activation in Tumorigenesis (2002) (221)
γ-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation (2003) (219)
ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1 (2011) (219)
Amyloid-beta precursor protein processing in neurodegeneration (2004) (217)
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. (2007) (216)
Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool (2016) (208)
The β-Secretase BACE1 in Alzheimer’s Disease (2020) (202)
Amyloid precursor protein promotes post‐developmental neurite arborization in the Drosophila brain (2005) (199)
A presenilin dimer at the core of the γ-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis (2003) (198)
Brain plasmin enhances APP α‐cleavage and Aβ degradation and is reduced in Alzheimer's disease brains (2000) (196)
Lessons from a Failed γ-Secretase Alzheimer Trial (2014) (195)
Lessons from a Failed γ-Secretase Alzheimer Trial (2014) (195)
Processing of β-Secretase by Furin and Other Members of the Proprotein Convertase Family* (2001) (194)
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes (2006) (190)
Interaction with Telencephalin and the Amyloid Precursor Protein Predicts a Ring Structure for Presenilins (2001) (189)
801 Expression in brain of Amyloid Precursor Protein mutated in the α-secretase site, causes disturbed behavior, neuronal degeneration and premature death in transgenic mice (1996) (189)
A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals (2016) (188)
Production of intracellular amyloid‐containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. (1995) (187)
ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase* (2009) (185)
Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation. (2015) (185)
ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death (2007) (183)
Comparison and meta-analysis of microarray data: from the bench to the computer desk. (2003) (177)
Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain (2017) (177)
A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases (2007) (176)
Pathogenic APP mutations near the γ-secretase cleavage site differentially affect Aβ secretion and APP C-terminal fragment stability (2001) (173)
Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission (2019) (171)
γ-secretases: from cell biology to therapeutic strategies (2010) (170)
The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein (2001) (169)
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway (2004) (167)
Differential contribution of the three Aph1 genes to γ-secretase activity in vivo (2005) (166)
Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons (1996) (165)
Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid-β1–42 Oligomers Are Revealed In Vivo by Using a Novel Animal Model (2012) (164)
Coordinated and widespread expression of γ-secretase in vivo: evidence for size and molecular heterogeneity (2004) (163)
Role of Presenilins in Neuronal Calcium Homeostasis (2010) (163)
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor (2011) (163)
The Orphan G Protein–Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons (2009) (163)
The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications (2019) (162)
Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. (2005) (162)
Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions (2017) (157)
The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Protease in Vivo* (2012) (153)
Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway (1993) (152)
Active γ-Secretase Complexes Contain Only One of Each Component* (2007) (151)
Presenilins: molecular switches between proteolysis and signal transduction (1999) (147)
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. (2002) (146)
Presenilin-1 deficiency leads to loss of Cajal–Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly (1999) (145)
Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer’s disease: a case series (2016) (145)
The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling (2011) (145)
Regulated Intramembrane Proteolysis of the Interleukin-1 Receptor II by α-, β-, and γ-Secretase* (2007) (143)
The beta‐amyloid domain is essential for axonal sorting of amyloid precursor protein. (1996) (142)
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease (2013) (140)
Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. (2000) (140)
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling (2017) (140)
The amyloid-beta precursor protein: integrating structure with biological function. (2005) (140)
Presenilin-1 Maintains a Nine-Transmembrane Topology throughout the Secretory Pathway* (2006) (138)
Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains (2009) (138)
Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44 (2003) (136)
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease. (2000) (136)
Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans (2020) (136)
Characterization of lentiviral vector-mediated gene transfer in adult mouse brain. (2002) (135)
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism (2015) (135)
Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. (2002) (135)
Peroxisome Proliferator-Activated Receptor γ Induces a Clearance Mechanism for the Amyloid-β Peptide (2004) (135)
BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells (2013) (135)
β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment (2012) (134)
BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease (2016) (134)
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition (2020) (133)
Elevation of β-Amyloid Peptide 2–42 in Sporadic and Familial Alzheimer's Disease and Its Generation in PS1 Knockout Cells* (2001) (132)
Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease (2013) (130)
Amyloid β Oligomers Disrupt Blood–CSF Barrier Integrity by Activating Matrix Metalloproteinases (2015) (129)
Contribution of Presenilin Transmembrane Domains 6 and 7 to a Water-containing Cavity in the γ-Secretase Complex* (2006) (129)
Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau (2018) (124)
Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease (2015) (124)
Presenilins: members of the gamma-secretase quartets, but part-time soloists too. (2008) (122)
Stem-cell-derived human microglia transplanted in mouse brain to study human disease (2019) (121)
Neuropathology and Neurodegeneration in Rodent Brain Induced by Lentiviral Vectormediated Overexpression of α‐Synuclein (2003) (118)
Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability. (2001) (117)
The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity (2015) (116)
Glu332 in the Nicastrin Ectodomain Is Essential for γ-Secretase Complex Maturation but Not for Its Activity* (2008) (115)
Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains. (2000) (115)
Loss‐of‐function presenilin mutations in Alzheimer disease (2007) (114)
miRNAs in Neurodegeneration (2007) (111)
Syndecan 3 Intramembrane Proteolysis Is Presenilin/γ-Secretase-dependent and Modulates Cytosolic Signaling* (2003) (111)
Notch Is a Critical Component of the Mouse Somitogenesis Oscillator and Is Essential for the Formation of the Somites (2009) (111)
Mitochondria dysfunction and neurodegenerative disorders: cause or consequence. (2010) (110)
Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions (2013) (110)
The Alzheimer Disease Protective Mutation A2T Modulates Kinetic and Thermodynamic Properties of Amyloid-β (Aβ) Aggregation* (2014) (108)
Presenilins Mutated at Asp-257 or Asp-385 Restore Pen-2 Expression and Nicastrin Glycosylation but Remain Catalytically Inactive in the Absence of Wild Type Presenilin* (2003) (108)
ADAM 10 mediates E-cadherin shedding and regulates epithelial cell – cell adhesion , migration , and-catenin translocation (2005) (107)
FAD mutant PS-1 gene-targeted mice: increased Aβ42 and Aβ deposition without APP overproduction (2002) (106)
Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo (2011) (105)
Epigenetically regulated microRNAs in Alzheimer's disease (2014) (104)
Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology (2020) (100)
The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics (2022) (100)
DNA-Dependent Protein Kinase Is Not Required for Efficient Lentivirus Integration (2000) (99)
miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain (2016) (99)
Microglia states and nomenclature: A field at its crossroads (2022) (99)
Endoplasmic Reticulum Stress-inducible Protein, Herp, Enhances Presenilin-mediated Generation of Amyloid β-Protein* 210 (2002) (98)
Noncoding RNAs in neurodegeneration (2017) (97)
Amyloidogenic Processing of Human Amyloid Precursor Protein in Hippocampal Neurons Devoid of Cathepsin D* (1996) (96)
Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. (2009) (94)
Dysregulated microRNAs in neurodegenerative disorders. (2010) (94)
The Yeast Complex I Equivalent NADH Dehydrogenase Rescues pink1 Mutants (2012) (93)
α2-macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease (1993) (93)
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation† (2011) (93)
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. (2005) (92)
The First Proline of PALP Motif at the C Terminus of Presenilins Is Obligatory for Stabilization, Complex Formation, and γ-Secretase Activities of Presenilins* (2001) (90)
Deficiency of Aph1B/C-γ-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment (2008) (90)
Redundancy and divergence in the amyloid precursor protein family (2013) (89)
Coordinated Metabolism of Alcadein and Amyloid β-Protein Precursor Regulates FE65-dependent Gene Transactivation* (2004) (89)
LifeTime and improving European healthcare through cell-based interceptive medicine (2020) (87)
1-(3′,4′-Dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanecarboxylic Acid (CHF5074), a Novel γ-Secretase Modulator, Reduces Brain β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease without Causing Peripheral Toxicity (2007) (86)
Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy. (2013) (85)
The World of Dementia Beyond 2020 (2011) (85)
Alzheimer's disease (2021) (85)
PINK1 Kinase Catalytic Activity Is Regulated by Phosphorylation on Serines 228 and 402* (2014) (84)
The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation (2013) (84)
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice. (2004) (83)
Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP (2018) (83)
Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons (2016) (82)
Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. (2003) (80)
Familial Alzheimer’s Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds (2016) (80)
Transmembrane Domain 9 of Presenilin Determines the Dynamic Conformation of the Catalytic Site of γ-Secretase* (2008) (79)
Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond. (2015) (78)
Alzheimer dementia caused by a novel mutation located in the APP C‐terminal intracytosolic fragment (2006) (77)
Structure and function of gamma-secretase. (2009) (76)
microRNA‐132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease (2017) (75)
Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures. (2011) (74)
Presenilins in Memory, Alzheimer's Disease, and Therapy (2004) (74)
Where Notch and WNT Signaling Meet (2001) (69)
Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments (2017) (69)
FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction. (2002) (68)
Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease. (2002) (67)
Basolateral Secretion of Amyloid Precursor Protein in Madin-Darby Canine Kidney Cells Is Disturbed by Alterations of Intracellular pH and by Introducing a Mutation Associated with Familial Alzheimer's Disease (*) (1995) (67)
Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore* (2011) (66)
Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease (2019) (66)
Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer’s Disease (2020) (65)
On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients (2015) (65)
miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a. (2015) (64)
Loss of γ-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis (2008) (64)
Implication of APP secretases in notch signaling (2001) (64)
Signature Amyloid β Profiles Are Produced by Different γ-Secretase Complexes* (2013) (64)
Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease (2012) (63)
Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice (2012) (63)
Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition (2019) (63)
Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics (2016) (63)
The Drosophila Homologue of the Amyloid Precursor Protein Is a Conserved Modulator of Wnt PCP Signaling (2013) (62)
Cellular senescence at the crossroads of inflammation and Alzheimer's disease (2021) (62)
Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets (2020) (62)
The Parkinson’s gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes (2014) (61)
Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer’s disease mouse models (2015) (61)
Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: A multi-electrode array study (2011) (61)
Neurodegeneration: From cellular concepts to clinical applications (2016) (60)
Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology (2018) (60)
ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor Protein* (2011) (59)
Comment on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models” (2013) (59)
Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome (2015) (57)
Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL−G−F mice before prominent plaque deposition (2017) (57)
Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2 (2018) (57)
Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10 (2017) (57)
Promiscuous Alzheimer's Amyloid: Yet Another Partner (2013) (57)
Distribution of the beta 1 subgroup of the integrins in human cells and tissues. (1989) (56)
Lessons from a failed γ-secretase Alzheimer trial. (2014) (56)
γ-Secretase: never more enigmatic (2001) (55)
Presenilins and the intramembrane proteolysis of proteins: facts and fiction (2001) (55)
LRRK2 expression is enriched in the striosomal compartment of mouse striatum (2012) (55)
Gamma-secretase and the intramembrane proteolysis of Notch. (2010) (54)
PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome (2018) (54)
The dynamic conformational landscape of γ-secretase (2015) (53)
Alzheimer's disease: where next for anti-amyloid therapies? (2017) (52)
Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse (2015) (52)
PARL: The mitochondrial rhomboid protease. (2016) (52)
Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond. (2015) (52)
De novo design of a biologically active amyloid (2016) (51)
Inhibition of β-Secretase in Vivo via Antibody Binding to Unique Loops (D and F) of BACE1* (2011) (50)
Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer’s Disease (2017) (50)
Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores (2021) (49)
Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: The need of larger datasets (2014) (48)
Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice (2015) (48)
Notch pathway is dispensable for adipocyte specification (2004) (48)
Expression of the novel intermediate filament-associated protein restin in Hodgkin's disease and anaplastic large-cell lymphoma. (1992) (48)
Functional and Topological Analysis of Pen-2, the Fourth Subunit of the γ-Secretase Complex*♦ (2011) (47)
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease. (2021) (46)
Alzheimer's disease: A firm base for drug development (1999) (46)
In Vitro Studies of Flemish, Dutch, and Wild-Type β-Amyloid Provide Evidence for Two-Staged Neurotoxicity (2002) (46)
Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription. (2008) (45)
Regulation of Amyloid Precursor Protein Processing by Serotonin Signaling (2014) (45)
Gene Dosage Effect on γ-Secretase Component Aph-1b in a Rat Model for Neurodevelopmental Disorders (2005) (44)
Alzheimer's disease: Mental plaque removal (2003) (44)
Erratum: ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and β-catenin nuclear signalling (The EMBO Journal (2005) 24 (742-752)) (2005) (44)
APLP2 regulates neuronal stem cell differentiation during cortical development (2013) (44)
Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer’s Disease (2018) (44)
Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brain (2013) (44)
A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes (2011) (44)
Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency (2017) (43)
Neurons Generated from APP/APLP1/APLP2 Triple Knockout Embryonic Stem Cells Behave Normally in Vitro and in Vivo: Lack of Evidence for a Cell Autonomous Role of the Amyloid Precursor Protein in Neuronal Differentiation (2010) (43)
Generation of a human induced pluripotent stem cell–based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration (2018) (42)
Gene profiling of hippocampal neuronal culture (2003) (42)
Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice (2013) (42)
Near-Infrared 808 nm Light Boosts Complex IV-Dependent Respiration and Rescues a Parkinson-Related pink1 Model (2013) (42)
Alzheimer's Disease: Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy (2012) (42)
Cultured human fibroblasts contain a large pool of precursor beta 1-integrin but lack an intracellular pool of mature subunit. (1991) (40)
Diabetes and Alzheimer’s Disease: A Link not as Simple as it Seems (2018) (39)
Aducanumab: a new phase in therapeutic development for Alzheimer’s disease? (2021) (38)
Molecular Plasticity Regulates Oligomerization and Cytotoxicity of the Multipeptide-length Amyloid-β Peptide Pool* (2012) (38)
Prion protein in Alzheimer's pathogenesis: a hot and controversial issue (2010) (38)
The primary sequence and the subunit structure of mouse alpha-2-macroglobulin, deduced from protein sequencing of the isolated subunits and from molecular cloning of the cDNA. (1992) (38)
Nicastrin: Gatekeeper of the γ-Secretase Complex (2005) (37)
Random Mutagenesis of Presenilin-1 Identifies Novel Mutants Exclusively Generating Long Amyloid β-Peptides* (2005) (37)
Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis (2019) (37)
Epigenetic control of aquaporin 1 expression by the amyloid precursor protein (2009) (37)
G Protein–Coupled Receptors, Cholinergic Dysfunction, and Aβ Toxicity in Alzheimer’s Disease (2009) (36)
Gene and MicroRNA Transcriptome Analysis of Parkinson's Related LRRK2 Mouse Models (2014) (36)
Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons (2016) (36)
BACE2 distribution in major brain cell types and identification of novel substrates (2018) (35)
Potential human transmission of amyloid β pathology: surveillance and risks (2020) (35)
Alterations in phosphatidylethanolamine levels affect the generation of Aβ (2012) (34)
Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice (2018) (34)
Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein. (1994) (34)
The case for low-level BACE1 inhibition for the prevention of Alzheimer disease (2021) (34)
A self-organizing miR-132/Ctbp2 circuit regulates bimodal notch signals and glial progenitor fate choice during spinal cord maturation. (2014) (34)
Secretases as therapeutic targets for the treatment of Alzheimer's disease (2001) (34)
Down-regulation of the ATP-binding Cassette Transporter 2 (Abca2) Reduces Amyloid-β Production by Altering Nicastrin Maturation and Intracellular Localization* (2011) (33)
The Alzheimer Disease Protective Mutation A2T Modulates Kinetic and Thermodynamic Properties of Amyloid-beta (A beta) Aggregation (2014) (32)
High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease (2018) (32)
Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer's disease. (2013) (32)
PLD3 gene and processing of APP (2017) (31)
Presenilins : Members of the-Secretase Quartets , But Part-Time Soloists Too (2008) (31)
Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics. (2016) (31)
Soluble amyloid-&bgr; precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans (2013) (31)
BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer’s Disease Markers in Elderly Healthy Participants (2017) (31)
Alzheimer's disease: Closing in on γ-secretase (2000) (30)
Nuclear import of the DSCAM‐cytoplasmic domain drives signaling capable of inhibiting synapse formation (2019) (30)
Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration (2017) (29)
Alzheimer's dementia by circulation disorders: when trees hide the forest (2009) (29)
Alzheimer's disease: An inflammatory drug prospect (2001) (29)
Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA. (1993) (28)
Nonfibrillar diffuse amyloid deposition due to a γ 42-secretase site mutation points to an essential role for N-truncated A β 42 in Alzheimer ’ s disease (2000) (28)
Developmental Expression of Wild-Type and Mutant Presenilin-1 in Hippocampal Neurons from Transgenic Mice: Evidence for Novel Species-Specific Properties of Human Presenilin-1 (1999) (28)
Signature Amyloid beta Profiles Are Produced by Different gamma-Secretase Complexes (2014) (27)
Exchanging the Extracellular Domain of Amyloid Precursor Protein for Horseradish Peroxidase Does Not Interfere with α-Secretase Cleavage of the β-Amyloid Region, but Randomizes Secretion in Madin-Darby Canine Kidney Cells(*) (1995) (27)
BACE1 and Presenilin: Two Unusual Aspartyl Proteases Involved in Alzheimer’s Disease (2004) (26)
The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives (2021) (26)
Stem-cell-derived human microglia transplanted into mouse brain to study human disease (2021) (26)
Conserved residues within the putative active site of γ‐secretase differentially influence enzyme activity and inhibitor binding (2004) (26)
Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling (2014) (26)
The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported. (1991) (26)
Nicastrin: gatekeeper of the gamma-secretase complex. (2005) (26)
Transgenic mice expressing an α-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder (1998) (24)
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation (2022) (24)
BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid. (2013) (23)
The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing (2011) (23)
Gene therapeutic strategies for neurodegenerative diseases. (2000) (23)
Learning by Failing: Ideas and Concepts to Tackle gamma-Secretases in Alzheimer's Disease and Beyond (2015) (23)
Monoclonal antibody DH12 reacts with a cell surface and a precursor form of the beta subunit of the human fibronectin receptor. (1988) (23)
Gamma-secretase: never more enigmatic. (2001) (22)
Close encounter: mitochondria, endoplasmic reticulum and Alzheimer's disease (2012) (22)
Presenilin Function in APP Processing (2000) (22)
A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer’s disease (2020) (22)
Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. (2013) (22)
Neuronal sorting and processing of amyloid precursor protein: implications for Alzheimer's disease. (1996) (22)
Alzheimer's disease: A breach in the blood–brain barrier (2012) (22)
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation (2021) (21)
Post‐translational modification of the β‐subunit of the human fibronectin receptor (1988) (21)
Structure and function of ?-secretase (2009) (21)
Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease (2020) (21)
γ-Secretase Heterogeneity in the Aph 1 Subunit : Relevance for Alzheimer ’ s Disease (2009) (20)
Alzheimer's disease: A protective mutation (2012) (20)
Tumour necrosis factor-alpha, interleukin-6 and interleukin-8 do not promote adhesion of human endometrial epithelial cells to mesothelial cells in a quantitative in vitro model. (2006) (20)
Deletion of exons 9 and 10 of the Presenilin 1 gene in a patient with Early-onset Alzheimer Disease generates longer amyloid seeds (2017) (20)
Defining Microglial States and Nomenclature: A Roadmap to 2030 (2022) (20)
Identification and in vivo characterization of a brain-penetrating nanobody (2020) (19)
Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model (2020) (19)
From Junk to Function: LncRNAs in CNS Health and Disease (2021) (19)
Peroxisome proliferator-activated receptor gamma enhances the activity of an insulin degrading enzyme-like metalloprotease for amyloid-beta clearance. (2010) (18)
Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia (2021) (18)
Small Molecules That Inhibit Notch Signaling (2014) (17)
α2-Macroglobulin and other proteinase inhibitors do not interfere with the secretion of amyloid precursor protein in mouse neuroblastoma cells (1992) (17)
Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity (2017) (17)
PINK1 activation-turning on a promiscuous kinase. (2015) (17)
Modulation of BACE1 Activity by Chemically Modified Aptamers (2018) (16)
Amyloid precursor protein accumulation in Lewy body dementia and Alzheimer's disease. (1995) (16)
The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation (2014) (16)
Mapping of human fibronectin receptorβ subunit gene to chromosome 10 (1988) (16)
γ-Secretase: never more enigmatic (2001) (16)
Where Notch and Wnt Signaling Meet: The Presenilin Hub (2001) (16)
Molecular cloning of the mouse gene coding for alpha 2-macroglobulin and targeting of the gene in embryonic stem cells. (1994) (16)
Axonal Odorant Receptors Mediate Axon Targeting (2019) (16)
CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. (2020) (16)
An overlooked neurotoxic species in Alzheimer's disease (2011) (15)
When the dust settles: what did we learn from the bexarotene discussion? (2013) (15)
γ-secretase inhibitors: Still in the running as Alzheimer's therapeutics (2004) (14)
Intramembranous processing by γ‐secretase regulates reverse signaling of ephrin‐B2 in migration of microglia (2017) (14)
Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease (2022) (14)
Spatial and temporal transcriptomics reveal microglia-astroglia crosstalk in the amyloid-β plaque cell niche of Alzheimer’s disease (2019) (14)
The function of presenilin-1 in amyloid β-peptide generation and brain development (1999) (13)
Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils. (2020) (13)
Identification and characterization of Nanobodies targeting the EphA4 receptor (2017) (13)
No endogenous Aβ production in presenilin-deficient fibroblasts (2002) (13)
Alzheimer's disease. Closing in on gamma-secretase. (2000) (13)
Macro Roles for MicroRNAs in the Life and Death of Neurons (2010) (13)
Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques (2021) (12)
Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein. (1995) (12)
The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research (2020) (12)
Computational Analysis of Alzheimer Amyloid Plaque Composition in 2D- and Elastically Reconstructed 3D-MALDI MS Images. (2020) (12)
The amyloid precursor protein is a conserved Wnt receptor (2021) (12)
Response to Shilling et al. (10.1074/jbc.M111.300491) (2012) (12)
Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer’s disease (2022) (11)
Epigenetic control of Aquaporin 1 expression by the amyloid precursor protein (2009) (11)
EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer’s disease (2019) (11)
Single nucleus sequencing fails to detect microglial activation in human tissue (2020) (11)
Peptides based on the presenilin‐APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain (2012) (11)
Screening and Characterization Strategies for Nanobodies Targeting Membrane Proteins. (2017) (11)
alpha 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease. (1993) (10)
Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500 (2013) (10)
The b-Secretase BACE1 in Alzheimer’s Disease (2020) (10)
No endogenous A beta production in presenilin-deficient fibroblasts. (2002) (10)
Decoding Darkness: The Search for the Genetic Causes of Alzheimer's Disease (2001) (9)
Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes. (1995) (9)
Response to Shilling et al. (2012) (8)
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model (2022) (8)
The cell biology of the beta-amyloid precursor protein (1998) (7)
ADAM 9 INHIBITION INCREASES MEMBRANE ACTIVITY OF ADAM 10 AND CONTROLS α − SECRETASE PROCESSING OF AMYLOID PRECURSOR PROTEIN (2011) (7)
Alzheimer's Disease Neurons Fail the Acid Test (2010) (7)
Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes (1998) (7)
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine (2021) (7)
Attack on amyloid (2003) (6)
THE CELL BIOLOGY OF AMYLOID PRECURSOR PROTEIN (1998) (6)
Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old AppNL/NL Knock-In Mice (2018) (6)
The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported. (1991) (6)
Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate (2002) (6)
Pyroptosis in Alzheimer’s disease: cell type-specific activation in microglia, astrocytes and neurons (2022) (6)
α2-macroglobulin and subacute-phase responses in Alzheimer's disease (1993) (5)
CRISPR/Cas9 screen in human iPSC‐derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity (2022) (5)
Morais Activity via NdufA 10 Ubiquinone Uncoupling PINK 1 Loss-of-Function Mutations Affect Mitochondrial Complex (2014) (5)
Stem cell derived human microglia transplanted in mouse brain to study genetic risk of Alzheimer’s Disease (2019) (5)
Diabetes and Alzheimer's disease: shared genetic susceptibility? (2022) (5)
Neuronal models to study amyloid precursor protein expression and processing in vitro. (2000) (5)
LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease (2022) (4)
Do we still need animals? Surveying the role of animal‐free models in Alzheimer’s and Parkinson’s disease research (2022) (4)
[Secretases as therapeutic targets for the treatment of Alzheimer's disease]. (2004) (4)
Alzheimer’s-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions (2021) (4)
Membrane orientation of the Alzheimer's disease associated presenilins (1999) (4)
Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice (2012) (4)
Long noncoding RNA MEG3 activates neuronal necroptosis in Alzheimer’s disease (2022) (4)
Fibronectin-Mediated Cellular (Inter)Actions (1989) (4)
MEA Neurosensor, the Tool for Synaptic Activity Detection: Acute Amyloid- β Oligomers Synaptotoxicity Study (2009) (4)
AAV mediated delivery of a novel anti-BACE1 VHH reduces Abeta in an Alzheimer’s disease mouse model (2019) (3)
Cancer and neurodegeneration meet (2010) (3)
Enteric neuronal function and colonic motility in PINK1-/- mice: A model for Parkinson's Disease (2012) (3)
Decoding Darkness: The Search for the Genetic Causes of Alzheimer's Disease (2001) (3)
Small molecules that inhibit Notch signaling. (2014) (3)
APLP2 regulates neuronal stem cell differentiation during cortical development (2013) (3)
Erratum: The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation [EMBO Mol Med, 5, (2013) 1523-1536, DOI: 10.1002/emmm.201302847] (2014) (3)
The presenilins as potential drug targets in Alzheimer’s disease (1999) (3)
Deletion of the hypoxia-response element in the VEGF promoter causes adult onset motor neuron degeneration (2002) (3)
Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity (2017) (3)
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo. (2012) (2)
Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice (2018) (2)
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo (Journal of Biological Chemistry (2012) 287, (25927-25940)) (2012) (2)
Corrigendum The (2014) (2)
Probing γ‐secretase–substrate interactions at the single amino acid residue level (2016) (2)
P4-172 Shedding of the ADAM10 ectodomain is mediated by ADAM9 and is followed by a processing of the ADAM10 CTF by presenilin/gamma-secretase (2004) (2)
Inhibition of β-secretase Results in a Retinal Phenotype Involving Both the Vasculature and the RPE (2012) (2)
A 68-kD antigen, which is probably an N-terminal fragment of the VLA-5 alpha 5-subunit, is specific for differentiating keratinocytes. (1996) (2)
Peroxisome Proliferator-Activated Receptor Gamma Enhances the Activity of an Insulin Degrading Enzyme-Like Metalloprotease for Amyloid-β Clearance (2010) (2)
Identification of Low Allele Frequency Mosaic Mutations in Alzheimer Disease (2017) (2)
Identification and characterization of Nanobodies targeting the EphA 4 receptor (2017) (2)
A multi-pronged human microglia response to Alzheimer’s disease Aβ pathology (2022) (2)
The composition of the γ-secretase complex defines its Aβ product profile (2013) (2)
In Vitro Comparison of the Activity Requirements and Substrate Specificity of Human and Triboleum castaneum PINK1 Orthologues (2016) (2)
Presenilin 1 interacts with a neuronal cell adhesion molecule and mediates its intracellular trafficking (2000) (2)
The AppNL-G-F mouse model of Alzheimer’s disease is refractory to regulatory T cell treatment (2022) (2)
The Dementia UK Ecosystem: a call to action (2021) (2)
Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons (2016) (2)
Closing in on γ-secretase (2000) (2)
Impaired adult hippocampal neurogenesis in Alzheimer’s disease is mediated by microRNA-132 deficiency and can be restored by microRNA-132 replacement (2020) (1)
Alpha 2-macroglobulin and subacute-phase responses in Alzheimer's disease. (1993) (1)
SECRETED AMYLOID PRECURSOR PROTEIN IS A GABABR1A LIGAND THAT SUPPRESSES SYNAPTIC VESICLE RELEASE (2018) (1)
Bexarotene treatment does not clear β-Amyloid in an AD mouse model and Beagle dogs (2013) (1)
Neuronal lithography with single cell resolution on chemically and topographically functionalised surfaces (2005) (1)
The Biology of the Presenilin Complexes (2007) (1)
Tau experimental models: effects of amyloid beta oligomers on tau pathology (2009) (1)
The deubiquitinase USP15 antagonizes Parkin-mediated mitophagy (2012) (1)
Trisomy of human chromosome 21 enhances amyloid-beta 3 deposition independently of an extra copy of APP (vol 141, pg 2457, 2018) (2019) (1)
Synaptic tau and synaptogyrin‐3 are promising targets to tackle tauopathies (2021) (1)
Deep proteomic analysis of human microglia and model systems reveal fundamental biological differences of in vitro and ex vivo cells (2022) (1)
Inhibition of amyloid Precursor Protein secretion by proteinase inhibitors suggests an intracellular localization of secretase (1993) (1)
Alpha 2-macroglobulin and other proteinase inhibitors do not interfere with the secretion of amyloid precursor protein in mouse neuroblastoma cells. (1992) (1)
Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model (2020) (1)
Neuronal differentiation of murine embryonic stem cells (2008) (1)
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a-mediated suppression of interferon alpha receptor (2013) (1)
Assay to probe proteolytic processing of Notch by γ-secretase. (2014) (1)
VHHs as tools for therapeutic protein delivery to the central nervous system (2022) (1)
Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B 2 in migration of microglia Running title ( 45 characters ) : γ-secretase / ephrinB 2 and microglial migration (2017) (1)
The composition of the g-secretase complex defines its Ab product profile (2013) (1)
LifeTime and improving European healthcare through cell-based interceptive medicine (2020) (1)
MIR-132: PROMOTING ADULT NEUROGENESIS IN ALZHEIMER’S DISEASE (2017) (1)
g-secretase-like protease mediates release of Notch intracellulardomain (1999) (1)
Dementia and COVID-19: a health and research funding crisis (2021) (1)
A novel fully-automated system for lifelong continuous phenotyping of mouse cognition and behaviour (2022) (1)
Cancer and neurodegeneration meet (2010) (1)
The processing of the Amyloid-Precursor-Protein in presenilin-1 deficient neurons (1998) (1)
A monoclonal antibody to the alpha 2 integrin subunit cross-reacts with RGD-dependent epitopes in fibrinogen. (1993) (1)
The A-beta 42/40 ratio is a driver of acute synaptotoxicity and LTP impairment (2010) (1)
Belgian Neurological Society (BNS) and Belgian Dementia Council (BeDeCo) Joint Scientific Meeting University of Antwerp, Belgium, December 10th, 2016 (2017) (1)
Regional lentiviral vector-mediated overexpression of alpha-synuclein in adult rodent brain (2001) (1)
P1-457: Neuronal differentiation of APP/APLP1/APLP2 triple knockout (tKO) embryonic stem (ES) cells (2008) (1)
When the dust settles: what did we learn from the bexarotene discussion? (2013) (1)
SOLUBLE AMYLOID PRECURSOR PROTEIN IS AN ISOFORM-SPECIFIC GABA(B) RECEPTOR LIGAND THAT SUPPRESSES SYNAPTIC RELEASE PROBABILITY (2017) (1)
Mitochondrial cardiolipin couples electron transport between ubiquinone and complex I to rescue PINK1 deficiency (2016) (1)
Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity (2017) (1)
mAb 8D9 reacts with α5-integrin and stains the stratum spinosum of adult skin (1990) (1)
O2-03-04: Aph1B gamma-secretase generates long Abeta peptides and genetic ablation improves Alzheimer's disease phenotypes without affecting notch signaling in the mouse (2008) (1)
Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology (2018) (0)
Abstract 1117: Investigating the role of PTEN-induced kinase 1 in cancer development and pathogenesis (2012) (0)
29Drosophila transgenic RNAi screen of genes implicated in human neurological disease (2011) (0)
Single cell biology to analyse cellular heterogeneity in the response to amyloid plaques in Alzheimer’s Disease (2022) (0)
P4-249: APP-dependent Aquaporin 1 expression in mouse embryonic fibroblasts (2008) (0)
Does it make sense for the early detection of Alzheimer's disease? (2014) (0)
Functions of the protease bace1 in the maturation of the nervous system (2006) (0)
LRRK2, a Gene Mutated in Parkinson's Disease, Promotes Synaptic Vesicle Endocytosis (2010) (0)
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine (2021) (0)
Combining In Vitro Cell Biology and In Vivo Mouse Modelling to Study the Mechanisms Underlying Alzheimer’s Disease (1995) (0)
Metabolic characterization of the integrin VLA-4 complex (1990) (0)
O4-03-08: Regulation and diversity of the gamma-secretase complex (2008) (0)
Modulation of the proteolytic processing of amyloid precursor protein (1999) (0)
Identification of a deubiquitinase that antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy (2014) (0)
1 ADAM 9 INHIBITION INCREASES MEMBRANE ACTIVITY OF ADAM 10 AND CONTROLS α − SECRETASE PROCESSING OF AMYLOID PRECURSOR PROTEIN (2011) (0)
S2–03–05: Cellular role of distinct Y–secretase complexes (2006) (0)
P2-121 In vivo consequences of BACE1 and BACE2 deficiency (2004) (0)
87th International Titisee Conference on Alzheimer's and Parkinson's disease: from basic science to therapeutic treatment (2003) (0)
EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer’s disease (2019) (0)
P1-287 Amyloid precursor protein isessential for survival after traumatic brain injury (2004) (0)
Missorting of the Dendritic Cell Adhesion Molecule Telencephalin in Presenilin-Deficient Neurons (2002) (0)
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling (2017) (0)
Astrocytes mediate neuronal network hyperactivity in early AD (2022) (0)
W3 - The cell biology of Alzheimer's Disease (2008) (0)
Long-term-depression and depotentiation are sensitive tools to detect synaptic impairments in the APP/PS1-21 and THY-tau-22 mouse models of Alzheimer’s disease (2014) (0)
Loss of synaptogyrin‐3 rescues tau‐induced memory defects and synaptic loss in the presence of microglial activation (2020) (0)
Secretases: potential and roadblocks on the way to therapy (2013) (0)
Biology and genetics of the presenilin proteins associated with alzheimer disease (1997) (0)
Evaluation of lentiviral vector mediated gene transfer into the adult mouse brain (2000) (0)
P3-264 A soluble ADAM10 ectodomain is released by ADAM9 and acts as an active membrane protein sheddase and Abeta degrading enzyme (2006) (0)
S2-03-05 Cellular role of distinct Y-secretase complexes (2006) (0)
Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to SynapticDeficits in Fragile X Syndrome (2015) (0)
O3-05-03 Genetic and biochemical analysis of the gamma-secretase complexes in mice (2004) (0)
O2-02-04: Lipids revert inert amyloid fibrils to neurotoxic protofibrils that affect learning in mice (2008) (0)
Role of presenilin 1 and presenilin 2 in APP and Notch processing (2000) (0)
P4-305 Identification and characterization of novel cleavage-defective presenilin-1 mutants (2004) (0)
Secretases: potential and roadblocks on the way to therapy (2013) (0)
An anti-α2 mAb which reacts with RGD (1990) (0)
The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research (2021) (0)
The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics (2022) (0)
European Alzheimer Disease Funding (2006) (0)
P4-313 Presenilin-1 induces NF-κB activation via a RIP-P62-APKC signaling cascade (2004) (0)
Endogenous Parkin and Ambra1 interact in neural cells to mediate mitophagy (2011) (0)
P2-075 APH1 knock-out mice (2004) (0)
Cell biology of the beta-secretase BACE1 (2002) (0)
The MIR-NAT MAPT-AS1 does not regulate Tau expression in human neurons (2023) (0)
174 Processing of APP in polarized epithelial cells and neurons: relationships among cell types (1996) (0)
Tudca, a bile acid, attenuates amyloid beta deposition and rescues memory deficits in app/ps1 mice (2011) (0)
Study on Functional Redundancy of LRRK1 and LRRK2 (2010) (0)
The molecular study of Alzheimer's disease: The road to a causal treatment (2010) (0)
GPR3 modulation of the Gamma-secretase complex and Abeta generation in Alzheimer's disease (2011) (0)
Bexarotene treatment does not clear β-Amyloid in an AD mouse model and Beagle dogs (2013) (0)
Role of Pink1 in Parkinson's Disease and Mitochondrial Function: Pink1 Regulates Complex I Activity (2010) (0)
Author response: Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling (2014) (0)
Neurodegeneration cell per cell (2023) (0)
Cell Reports Resource The Major Risk Factors for Alzheimer ’ s Disease : Age , Sex , and Genes Modulate the Microglia Response to A b Plaques (2019) (0)
P4-373 A knock down screen for identification of putative Alzheimer's disease modifying drugable genes that modulate amyloid levels (2004) (0)
TRISOMY 21 CAUSES A DEFICIT IN LYSOSOMAL CATHEPSINS AND ALTERS APP/Aβ PROCESSING, INDEPENDENTLY OF AN EXTRA COPY OF APP (2017) (0)
Aβ production in the brains of familial Alzheimer’s disease patients (2015) (0)
A cell biological study the Alzheimer's disease (1999) (0)
1-(3 ,4 (cid:1) -Dichloro-2-fluoro[1,1 (cid:1) -biphenyl]-4-yl)-cyclopropanecarboxylic Acid (CHF5074), a Novel (cid:1) -Secretase Modulator, Reduces Brain (cid:2) -Amyloid Pathology in a Transgenic Mouse Model of Alzheimer’s Disease without Causing Peripheral Toxicity (2007) (0)
Hyperspectral retinal imaging in mouse models of proteinopathies identifies disease‐specific signatures (2022) (0)
Enriched expression of LRRK 2 in the striosomal compartment of mouse striatum (2012) (0)
Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques (2021) (0)
Gene transfer into neuronal cells using lentiviral vectors (1999) (0)
Systematic evaluation of the therapeutic potential of microRNA‐132 in Alzheimer's disease (2021) (0)
21-P047 Notch is essential for the mouse segmentation clock (2009) (0)
The characterisation of integrins on neuroblastoma and glioma cells (1990) (0)
Parl Deficiency in Mouse Causes Coenzyme Q Depletion, Complex III Defects, and Leigh-like Syndrome (2018) (0)
P1-407: Changes in microRNA expression in the brain might contribute to sporadic Alzheimer's disease (2008) (0)
Parkin mediates mitophagy through interaction with Ambra1 (2010) (0)
Abstract 20667: Cardiomyocyte miR-29 Promotes Cardiac Remodelling (2014) (0)
APP knock-in (NLGF) model of Alzheimer’s disease: accelerated Aβ pathology leads to cognitive, synaptic and neuronal synchrony deficits (2016) (0)
Notch is essential for the mouse segmentation clock (2009) (0)
1H, 13C, and 15N chemical shift assignments of the Sushi 1 domain of GABAbR1a (2019) (0)
Induction of tau pathology, tangles and necroptosis in human neurons exposed to amyloid plaques in chimeric mouse brain (2021) (0)
ADAM10 cleavage of N‐cadherin and regulation of cell–cell adhesion and β‐catenin nuclear signalling (2013) (0)
Chimeric models to analyze human neuron and astroglia responses in Alzheimer's disease (2020) (0)
A soluble ADAM10 ectodomain is released by ADAM9 and acts as an active sheddase and abeta degrading enzyme (2006) (0)
Biophysical consideration of gamma secretase modulation as potential target for Alzheimer's disease. Consequences of amyloid-beta peptide lenght variation (2011) (0)
Risk factor for Alzheimers's disease: Pathological ABETA 40/42 ratio facilitates formation of stable neurotoxic oligomers (2011) (0)
Stem-cell-derived human microglia transplanted in mouse brain to study human disease (2019) (0)
DIADEM / Participants Directory (2004) (0)
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease (2012) (0)
The Presenilin/gamma-secretase complex and its potential as a drug target in Alzheimer’s Disease (2006) (0)
MiR-29a Maintains Hematopoietic Stem Cell Self-Renewal and Is Required For Myeloid Leukemogenesis (2013) (0)
The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives (2021) (0)
P4-270 A γ-secretase independent role for presenilin 1 in telencephalin turnover in hippocampal neurons (2004) (0)
Unbiased profiling of miR‐132 targetome with implications in adult hippocampal neurogenesis and Alzheimer’s disease (2021) (0)
Beta-arrestin 2 regulates GPCR dysfunction in Alzheimer's disease (2013) (0)
University education is more than higher education (1992) (0)
Blood plasma biomarkers improve prediction accuracy over and above genetic predictors of Alzheimer’s disease (2022) (0)
α2‐Macroglobulin and other proteinase inhibitors do not interfere with the secretion of amyloid precursor protein in mouse neuroblastoma cells (2001) (0)
Poster session: Modulation of Amyloid-Beta burden-mediated learning and memory defects: role of in vitro and in vivo assemblies (2011) (0)
Synaptic Contacts Enhanc e Cell-to-Cell Tau Pathology Propagation Graphical (0)
TARGETING SECRETASES IN THE PRODROMAL, CELLULAR PHASE OF ALZHEIMER DISEASE (2016) (0)
LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease (2022) (0)
organ-specific vascular structures Deletion of Adam 10 in endothelial cells leads to defects in (2011) (0)
Identification and in vivo characterization of a brain-penetrating nanobody (2020) (0)
P2-084 BACE1 and BACE2 deficient mice (2004) (0)
Alzheimer research forum discussion: Gain or loss of function - Time to shake up assumptions on γ-secretase in Alzheimer disease? Commentary (2007) (0)
Aph1 knock-out mice (2004) (0)
Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils (2020) (0)
The composition of the γ-secretase complex defines its Aβ product profile (2013) (0)
Apoptotic cell death in disease—Current understanding of the NCCD 2023 (2023) (0)
Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments (2017) (0)
Diabetes and Alzheimer’s Disease: A Link not as Simple as it Seems (2018) (0)
On the topic of : ? The role of LRRK 2 in synaptic vesicle recycling and potential relevance for Parkinson disease ? (2016) (0)
Role of Endothelial Cell Adam-10 In Murine Developmental Angiogenesis and Proliferative Retinopathies (2011) (0)
Acknowledgement of Reviewers (2006) (0)
P2-130 A nuclear transcription factor involved in the downregulation of the amyloid Aβ peptide levels (2004) (0)
Gene transfer into adult mouse brain using lentiviral vectors (1999) (0)
Alzheimer’s disease‐related necroptotic pathology: An exclusive presence of the necrosome in granulovacuolar degeneration inclusions in human and transgenic mouse brains (2020) (0)
Developmental Expression ofWild-Typeand MutantPresenilin-l inHippocampalNeurons fromTransgenic Mice:EvidenceforNovelSpecies- Specific Properties ofHuman Presenilin-I (1999) (0)
Amyloid precursor protein is essential for survival after traumatic brain injury (2004) (0)
miR-29a maintains hematopoietic stem cell self-renewal and is required for leukemic transformation (2013) (0)
The two major familial Alzheimer's Disease gene products, presenilin 1 and amyloid precursor protein interact functionally (1998) (0)
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer’s disease (2013) (0)
functionofPS1,indicatingthattheobservedeffectsarediseasespecific.Ourobservationsareconsistentwith thepotentialroleofdisturbedCa 2+ homeostasisinAlzheimerdiseasepathogenesis. (2007) (0)
Editorial overview: Neurobiology of disease (2022) (0)
Secretase dysfunction at the core of Familial Alzheimer disease (2012) (0)
Evaluation of immune response and neuroinflammation after lentiviral vector-mediated gene transfer into adult rodent brain (2001) (0)
Subtle defects in cognitive flexibility and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before plaque deposition (2018) (0)
P3-398 Cysteine scanning mutagenesis as a tool for structure-function analysis of presenilin 1 (2006) (0)
Apresenilin-1-dependent g-secretase-likeprotease mediates releaseofNotch intracellulardomain (1999) (0)
The putative role of presenilins in the transmembrane domain cleavage of Amyloid Precursor Protein and other integral membrane proteins (2001) (0)
NEUROFILAMENT LIGHT IN ISOPOTENTIAL STEM CELL-DERIVED NEURONS WITH FAMILIAL AD MUTATIONS AS A MARKER OF NEURODEGENERATION (2019) (0)
Parkin interacts with Ambra1 to induce mitophagy (award for best poster presentation) (2011) (0)
Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer’s Disease Brains and Mouse Neurodegeneration Models (2022) (0)
Impact of central fragment of the HIV-1 genome on lentiviral vector performance (2001) (0)
Destabilized γ-Secretase-Aβn interactions cause Alzheimer’s disease, implications for drug discovery (2017) (0)
L’expérimentation animale reste indispensable (OPINION) (2017) (0)
Presenilin 1 Controls (cid:103) -Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons (1999) (0)
P4-204: A water-containing cavity in the catalytic core of the gamma-secretase complex (2008) (0)
Gene transfer of wild-type en mutant human alpha-synuclein into adult rodent brain by means of lentiviral vectors (2001) (0)
Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease (2020) (0)
Melanin Concentrating Hormone- and sleep-dependent synaptic downscaling is impaired in Alzheimer’s Disease (2021) (0)
P4-269 Structure-function studies on presenilins in PS null fibroblasts (2004) (0)
Secretases: potential and roadblocks on the way to therapy (2013) (0)
Alzheimer’s Disease:: Fundamental Research Paves the Way for Therapeutics (2008) (0)
Poster session: Chronic treatment with tauroursodeoxycholic acid ameliorates memory deficits in APP/PS1 mice, a mouse model for Alzheimer's disease (2011) (0)
P1-410 The intracellular domain of the amyloid-beta precursor protein is not involved in nuclear signaling (2006) (0)
DISTINCT Aβ PRODUCTION IN STEM CELL-DERIVED CORTICAL NEURONS FROM PATIENTS WITH FAD MUTATION (2017) (0)
Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia (2021) (0)

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