Derrick Rossi
#172,363
Most Influential Person Now
Canadian stem cell biologist
Derrick Rossi's AcademicInfluence.com Rankings
Derrick Rossibiology Degrees
Biology
#14738
World Rank
#18571
Historical Rank
Immunology
#1034
World Rank
#1060
Historical Rank
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Biology
Derrick Rossi's Degrees
- PhD Immunology Stanford University
Why Is Derrick Rossi Influential?
(Suggest an Edit or Addition)According to Wikipedia, Derrick J. Rossi , is a Canadian stem cell biologist and entrepreneur. He is a co-founder of the biotechnology company Moderna. Early life and education Rossi was born in Toronto as the youngest of five children of a Maltese immigrant family. His father Fred worked in auto body shops for 50 years and his mother Agnes co-owned a Maltese bakery.
Derrick Rossi's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. (2010) (2537)
- Somatic coding mutations in human induced pluripotent stem cells (2011) (1218)
- Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age (2007) (1042)
- Cell intrinsic alterations underlie hematopoietic stem cell aging. (2005) (1039)
- Stems Cells and the Pathways to Aging and Cancer (2008) (843)
- Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. (2006) (752)
- Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age (2011) (692)
- A comprehensive methylome map of lineage commitment from hematopoietic progenitors (2010) (626)
- Human iPSC-based modeling of late-onset disease via progerin-induced aging. (2013) (609)
- Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. (2007) (605)
- Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion (2010) (586)
- Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells (2011) (563)
- Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction (2013) (504)
- Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp‐2 (1997) (474)
- Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9. (2014) (415)
- Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth (2008) (409)
- Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. (2013) (391)
- Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle. (2014) (364)
- Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein (1995) (364)
- Ephrin-B2 and EphB1 Mediate Retinal Axon Divergence at the Optic Chiasm (2003) (344)
- DNA methylation dynamics during in vivo differentiation of blood and skin stem cells. (2012) (344)
- Vascular Abnormalities and Deregulation of VEGF in Lkb1-Deficient Mice (2001) (324)
- Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML (2012) (316)
- Molecular definition of the identity and activation of natural killer cells (2012) (230)
- Gene Expression Commons: An Open Platform for Absolute Gene Expression Profiling (2012) (223)
- Stem cells and the aging hematopoietic system. (2010) (221)
- Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease (2016) (200)
- Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors (2014) (193)
- Reprogramming human fibroblasts to pluripotency using modified mRNA (2013) (187)
- DNA damage response in adult stem cells: pathways and consequences (2011) (176)
- Hematopoietic Stem Cell Quiescence Attenuates DNA Damage Response and Permits DNA Damage Accumulation During Aging (2007) (173)
- DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier (2014) (169)
- A multiply redundant genetic switch ‘ locks in ’ the transcriptional signature of regulatory T cells (2012) (163)
- Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin (2016) (156)
- Fgd5 identifies hematopoietic stem cells in the murine bone marrow (2014) (150)
- Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2. (2016) (149)
- Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis (2002) (140)
- Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors (2014) (134)
- Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease. (2015) (132)
- Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning (2006) (131)
- Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci. (2011) (130)
- Hematopoietic stem cell aging: Mechanism and consequence (2007) (125)
- Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells (2007) (116)
- Niche recycling through division-independent egress of hematopoietic stem cells (2009) (116)
- SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity. (2007) (115)
- A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System (2018) (105)
- A multiple redundant genetic switch locks in the transcriptional signature of T regulatory cells (2012) (105)
- Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1 (2001) (96)
- Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation (2019) (94)
- Transcriptome Analysis Identifies Regulators of Hematopoietic Stem and Progenitor Cells (2013) (92)
- Pten, Tumorigenesis, and Stem Cell Self-Renewal (2006) (89)
- Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. (2004) (84)
- Stem cells and aging in the hematopoietic system (2009) (79)
- Hematopoietic stem cells and the aging hematopoietic system. (2008) (77)
- Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR–Cas9 genome editing (2017) (65)
- Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. (2007) (63)
- Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress. (2019) (62)
- Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging (2018) (61)
- Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis (2016) (58)
- Transcriptional instability is not a universal attribute of aging (2007) (55)
- Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development (2009) (53)
- Epigenetic regulation of hematopoietic stem cell aging. (2014) (52)
- Differential DNA damage response in stem and progenitor cells. (2010) (44)
- The transcriptional landscape of ab T cell differentiation (2013) (42)
- Distinct human α(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells (2018) (42)
- A Common Origin for B-1a and B-2 Lymphocytes in Clonal Pre- Hematopoietic Stem Cells (2017) (39)
- Transcription factor‐mediated reprogramming toward hematopoietic stem cells (2015) (37)
- The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice. (2015) (36)
- Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage (2018) (33)
- Glycoengineering of E‐Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells (2016) (33)
- Intracerebroventricular delivery of hematopoietic progenitors results in rapid and robust engraftment of microglia-like cells (2017) (30)
- Conditional ablation of the Mat1 subunit of TFIIH in Schwann cells provides evidence that Mat1 is not required for general transcription (2002) (29)
- Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation (2019) (29)
- DNA-Damage-Induced Differentiation in Hematopoietic Stem Cells (2012) (27)
- Ectopic expression of RAD 52 and dn 53 BP 1 improves homology-directed repair during CRISPR – Cas 9 genome editing (2017) (27)
- The Histidine Triad Protein Hint Is Not Required for Murine Development or Cdk7 Function (2003) (26)
- Targets and genomic constraints of ectopic Dnmt3b expression (2018) (23)
- Excision of a viral reprogramming cassette by delivery of synthetic Cre mRNA. (2012) (23)
- mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell–derived hematopoietic progenitors (2017) (22)
- ImmGen at 15 (2020) (21)
- Genome editing for human gene therapy. (2014) (19)
- Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR / Cas 9 Graphical (2014) (17)
- Rapid Lymphocyte Reconstitution of Unconditioned Immunodeficient Mice with Non-Self-Renewing Multipotent Hematopoietic Progenitors (2006) (17)
- ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells. (2017) (16)
- Growth hormone receptor signaling is dispensable for HSC function and aging. (2014) (16)
- Deciphering developmental stages of adult myelopoiesis (2008) (16)
- Perturbation of the Hematopoietic System during Embryonic Liver Development Due to Disruption of Polyubiquitin Gene Ubc in Mice (2012) (14)
- Insulin-like growth factor 2 modulates murine hematopoietic stem cell maintenance through upregulation of p57. (2016) (13)
- Abnormal mesoderm patterning in mouse embryos mutant for the SH 2 tyrosine phosphatase Shp-2 which comprise a large family of transmembrane and (1997) (13)
- Fgd 5 identifies hematopoietic stem cells in the murine bone marrow (2014) (10)
- Reply to Kerbel et al.: EPCs are again claimed to be essential in yet other models despite the irreproducibility of the original experiments introducing them (2008) (9)
- Progress and obstacles towards generating hematopoietic stem cells from pluripotent stem cells (2015) (8)
- Reactive oxygen species resulting from mitochondrial mutation diminishes stem and progenitor cell function. (2012) (6)
- Two new routes to make blood: Hematopoietic specification from pluripotent cell lines versus reprogramming of somatic cells. (2015) (5)
- Controlling stem cell fate one substrate at a time (2010) (5)
- 10 Aging in Mammalian Stem Cells and Other Self-renewing Compartments (2008) (4)
- Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation (2019) (3)
- Loss of P2Y₁₄ results in an arresting response to hematological stress. (2014) (2)
- RNA polymerase II C-terminal domain kinases in heart failure (2003) (2)
- Author response: Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging (2018) (2)
- Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation (2019) (1)
- AGE-associated clonal dominance of myeloid-biased HSC is underwritten by unique transcriptional and epigenetic alterations (2015) (1)
- Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells (2007) (1)
- Distinct human (cid:2) (1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells (2020) (1)
- Author response: Targets and genomic constraints of ectopic Dnmt3b expression (2018) (1)
- DNA Damage and Aging Around the Clock. (2016) (1)
- Completely Non-Myeloablative/Non-Lymphoablative Conditioning for BMT/HSCT Using Anti-Ckit Immunotoxins (2016) (1)
- Twisting mice move the dystonia field forward (2014) (1)
- Immune Sparing Conditioning for BMT/HSCT Using Anti-Ckit Immunotoxins (2018) (0)
- Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages the Immunological (2012) (0)
- Hematopoietic stem cells are active contributors to hematopoiesis in steady state (2016) (0)
- aging Growth hormone receptor signaling is dispensable for HSC function and (2014) (0)
- Hematopoietic stem cell self-renewal is tightly regulated. Regulation of the stability of c-Myc protein contributes to this control of hematopoietic stem cell quiescence and repopulation. (2010) (0)
- Telomere length and haematopoietic stem cell adaptation in mice compromised for telomerase activity (2008) (0)
- Functional Analysis of Cell Cycle Regulators Lkb1 and Mat1 in Genetically Engineered Mice (2002) (0)
- Focus : Induced Pluripotency & Cellular Reprogramming Transcription factor-mediated reprogramming toward hematopoietic stem cells (2015) (0)
- Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage (2018) (0)
- Glycoengineering of E-selectin ligands by intrinsic versus extrinsic fucosylation differentially affects osteotropism of human mesenchymal stem cells (2016) (0)
- of rare niches corrects severe lymphoid defi ciencies without host conditioning (2006) (0)
- Transcriptional insights into the CD8[superscript +] T cell response to infection and memory T cell formation (2013) (0)
- Abstract 1565: Menage-A-Trois 1 Physically Associates with PGC-1 and is Essential for Cardiac Mitochondrial Function (2006) (0)
- Erratum: Hematopoietic reconstitution by multipotent adult progenitor cells: Precursors to long-term hematopoietic stem cells (Journal of Experimental Medicine (January 22, 2007) 204, 1, (129-139) (2007) (0)
- [From animal models to human trials of Peutz-Jeghers syndrome]. (2004) (0)
- HSCs Contribute Actively to Native Multilineage Hematopoiesis but With Reduced Differentiation Capacity Upon Aging (2018) (0)
- Making hematopoietic stem cells backwards (2014) (0)
- Loss of P 2 Y 14 results in an arresting response to hematological stress (2018) (0)
- 568. Transient Manipulation of DNA Damage Repair Pathway Choice Improves Homology-Directed Repair During CRISPR/Cas9-Mediated Genome Editing (2016) (0)
- Hematopoietic stem cell quiescence attenuates DNA damage repair and response contributing to age-dependent DNA damage accumulation (2014) (0)
- Conservation and divergence in modules of the transcriptional programs of the human and mouse immune systems (2018) (0)
- Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR–Cas9 genome editing (2017) (0)
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What Schools Are Affiliated With Derrick Rossi?
Derrick Rossi is affiliated with the following schools:
