David A. Sinclair | Academic Influence

David A. Sinclair's AcademicInfluence.com Rankings

David A. Sinclair

Biology

#4732

World Rank

#7027

Historical Rank

Genetics

#509

World Rank

#584

Historical Rank

Molecular Biology

#617

World Rank

#632

Historical Rank

biology Degrees

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Biology

Why Is David A. Sinclair Influential?

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According to Wikipedia, David Andrew Sinclair is an Australian-American biologist and academic known for his research on aging and epigenetics. Sinclair is a professor of genetics at Harvard Medical School and is the co-director of its Paul F. Glenn Center for Biology of Aging Research. He is the president of the non-profit Academy for Health & Lifespan Research and an officer of the Order of Australia .

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David A. Sinclair's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Resveratrol improves health and survival of mice on a high-calorie diet (2006) (4154)
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan (2003) (3604)
Therapeutic potential of resveratrol: the in vivo evidence (2006) (3530)
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase (2004) (3112)
Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase (2004) (1920)
Mammalian sirtuins: biological insights and disease relevance. (2010) (1797)
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes (2007) (1653)
Sirtuins in mammals: insights into their biological function. (2007) (1589)
Extrachromosomal rDNA Circles— A Cause of Aging in Yeast (1997) (1435)
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. (2012) (1271)
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. (2008) (1131)
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging (2013) (1074)
Metformin improves healthspan and lifespan in mice (2013) (1031)
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis (2007) (1001)
Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1* (2002) (973)
The intersection between aging and cardiovascular disease. (2012) (841)
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. (2011) (800)
Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival (2007) (752)
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae (2003) (725)
The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. (2014) (711)
Molecular Biology of Aging (1999) (697)
SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging (2008) (651)
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. (2007) (639)
Why does COVID-19 disproportionately affect older people? (2020) (617)
The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth (2008) (606)
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. (2004) (604)
Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators (2013) (558)
Toward a unified theory of caloric restriction and longevity regulation (2005) (557)
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. (2012) (526)
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds (2016) (506)
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy (2010) (482)
Small molecule SIRT1 activators for the treatment of aging and age-related diseases. (2014) (475)
Interventions to Slow Aging in Humans: Are We Ready? (2015) (462)
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. (2018) (452)
SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity (2010) (429)
CORRIGENDUM: SRT1720 improves survival and healthspan of obese mice (2013) (411)
Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. (1997) (393)
Redistribution of Silencing Proteins from Telomeres to the Nucleolus Is Associated with Extension of Life Span in S. cerevisiae (1997) (388)
NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. (2016) (346)
MEC1-Dependent Redistribution of the Sir3 Silencing Protein from Telomeres to DNA Double-Strand Breaks (1999) (333)
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside (2015) (327)
MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae (2007) (325)
The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet. (2014) (319)
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. (2016) (303)
NAD+ in Brain Aging and Neurodegenerative Disorders. (2019) (287)
Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (2018) (277)
Reprogramming to recover youthful epigenetic information and restore vision (2020) (273)
Xenohormesis: Sensing the Chemical Cues of Other Species (2008) (271)
SRT1720 improves survival and healthspan of obese mice (2011) (266)
The role of nuclear architecture in genomic instability and ageing (2007) (265)
Sirtuin activators and inhibitors: Promises, achievements, and challenges. (2018) (252)
Longevity Regulation in Saccharomyces cerevisiae: Linking Metabolism, Genome Stability, and Heterochromatin (2003) (247)
When stem cells grow old: phenotypes and mechanisms of stem cell aging (2016) (247)
HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction (2005) (242)
Manipulation of a Nuclear NAD+ Salvage Pathway Delays Aging without Altering Steady-state NAD+ Levels* (2002) (226)
Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38 (2013) (210)
Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. (2018) (210)
The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet‐induced obesity (2007) (209)
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases (2018) (205)
MicroReview: Small molecules that regulate lifespan: evidence for xenohormesis (2004) (205)
Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production (2018) (203)
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass (2014) (195)
Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species (195)
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site (2015) (194)
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. (2013) (192)
Small-molecule allosteric activators of sirtuins. (2013) (191)
Aging in Saccharomyces cerevisiae. (1998) (178)
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan (2014) (177)
Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. (2013) (177)
Germline energetics, aging, and female infertility. (2013) (166)
Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. (1999) (165)
Yeast Life-Span Extension by Calorie Restriction Is Independent of NAD Fluctuation (2003) (164)
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. (2005) (160)
SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. (2011) (160)
Stimulus Specificity of Gene Expression Programs Determined by Temporal Control of IKK Activity (2013) (156)
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase (2001) (156)
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy (2009) (154)
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling (2011) (148)
SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation (2016) (143)
Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles (2018) (140)
Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice (2019) (136)
Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. (2012) (130)
Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells (2014) (127)
A conserved NAD+ binding pocket that regulates protein-protein interactions during aging (2017) (121)
Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome. Diabetes 2013;62:1084–1093 (2014) (121)
The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression (2014) (121)
Molecular mechanisms of yeast aging. (1998) (121)
Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein* (2011) (119)
Nampt/PBEF/Visfatin: A regulator of mammalian health and longevity? (2006) (118)
Epigenetic changes during aging and their reprogramming potential (2019) (115)
NAD+ Repletion Rescues Female Fertility during Reproductive Aging (2020) (109)
The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction (2012) (103)
Identification of a SIRT1 mutation in a family with type 1 diabetes. (2013) (102)
SIRT 1 deacetylase protects against neurodegeneration in models for Alzheimer ’ s disease and amyotrophic lateral sclerosis (2013) (97)
SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity (2010) (96)
Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins. (2019) (95)
Design and synthesis of compounds that extend yeast replicative lifespan (2007) (93)
Why NAD(+) Declines during Aging: It's Destroyed. (2016) (92)
Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation (2007) (90)
Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice (2014) (90)
JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks (2016) (88)
Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease. (2019) (87)
Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) (85)
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. (2013) (85)
The ageing epigenome: Damaged beyond repair? (2009) (82)
Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice (2018) (80)
Paradigms and pitfalls of yeast longevity research (2002) (80)
Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway (2013) (78)
Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. (2011) (76)
Dietary restriction involves NAD+-dependent mechanisms and a shift toward oxidative metabolism (2014) (75)
Unlocking the secrets of longevity genes. (2006) (75)
Dietary restriction: standing up for sirtuins. (2010) (70)
Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency (2016) (70)
O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway (2016) (68)
Head to Head Comparison of Short-Term Treatment with the NAD+ Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice (2016) (66)
Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults (2017) (65)
Sirtuins: a conserved key unlocking AceCS activity. (2007) (61)
Unlocking the secrets of longevity genes (2006) (60)
The role of protein arginine methylation in the formation of silent chromatin. (2006) (59)
Prolyl Isomerase Pin1 Regulates Neuronal Differentiation via β-Catenin (2012) (59)
A High-Confidence Interaction Map Identifies SIRT1 as a Mediator of Acetylation of USP22 and the SAGA Coactivator Complex (2013) (58)
C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins (2016) (56)
Age and life expectancy clocks based on machine learning analysis of mouse frailty (2019) (55)
Frailty biomarkers in humans and rodents: Current approaches and future advances (2019) (54)
Biomarkers of biological age as predictors of COVID-19 disease severity (2020) (54)
Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis. (2014) (54)
Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age‐related insulin resistance (2016) (52)
Randomized clinical trial to evaluate mental practice in enhancing advanced laparoscopic surgical performance (2015) (51)
Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise (2017) (47)
Small molecule SIRT 1 activators for the treatment of aging and age-related diseases (2014) (47)
The economic value of targeting aging (2021) (45)
Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase (2011) (45)
Sex differences in the response to dietary restriction in rodents. (2018) (42)
Sirtuins for healthy neurons (2005) (42)
Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability (2015) (41)
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast (2009) (41)
Life-Span Extension in Yeast (2006) (40)
Impact papers on aging in 2009 (2010) (40)
Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach (2017) (38)
Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. (2018) (37)
Characterization of murine SIRT3 transcript variants and corresponding protein products (2010) (36)
The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. (2020) (36)
DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging (2019) (34)
Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance (2017) (34)
What is Xenohormesis? (2008) (33)
Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy (2013) (33)
Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14 (2018) (33)
Aging: past, present and future (2009) (33)
Why Does COVID-19 Disproportionately Affect the Elderly? (2020) (32)
Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage (2019) (31)
Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals (2019) (31)
SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition* (2015) (30)
Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer‐based precipitation and size exclusion chromatography (2021) (28)
SIRT 1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity (2010) (27)
Specific induction by glycine of the gene for the P‐subunit of glycine decarboxylase from Saccharomyces cerevisiae (1996) (26)
ARDD 2020: from aging mechanisms to interventions (2020) (25)
TPE or not TPE? It's no longer a question. (2002) (25)
Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay. (2013) (24)
SIRT 2 induces the checkpoint kinase BubR 1 to increase lifespan (2014) (24)
Response to Comment on "HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction" (2006) (24)
Role of the N‐terminal region of Rap1p in the transcriptional activation of glycolytic genes in Saccharomyces cerevisiae (2004) (23)
17 Molecular Mechanisms of Aging: Insights from Budding Yeast (2008) (23)
Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (2019) (23)
Identification of a SIRT 1 Mutation in a Family with Type 1 Diabetes (2013) (22)
The "metabolic winter" hypothesis: a cause of the current epidemics of obesity and cardiometabolic disease. (2014) (21)
Studying the replicative life span of yeast cells. (2013) (21)
Small molecules that regulate lifespan: evidence for xenohormesis: Small molecules that regulate lifespan (2004) (21)
Sirtuin1 Over-Expression Does Not Impact Retinal Vascular and Neuronal Degeneration in a Mouse Model of Oxygen-Induced Retinopathy (2014) (20)
The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice. (2015) (20)
Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. (2020) (18)
Impairment of an Endothelial NAD +-H 2 S Signaling Network Is a Reversible Cause of Vascular Aging Graphical Abstract Highlights (2018) (17)
Nicotinamide Impairs Entry into and Exit from Meiosis I in Mouse Oocytes (2015) (17)
Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming (2019) (17)
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene (2013) (17)
Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice (2019) (17)
Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism (2013) (16)
Control of Expression of One-carbon Metabolism Genes ofSaccharomyces cerevisiae Is Mediated by a Tetrahydrofolate-responsive Protein Binding to a Glycine Regulatory Region Including a Core 5′-CTTCTT-3′ Motif* (1999) (16)
GLTSCR2/PICT1 links mitochondrial stress and Myc signaling (2014) (16)
Oogonial stem cells as a model to study age-associated infertility in women. (2015) (15)
NAD+ in COVID-19 and viral infections (2022) (14)
A blueprint for developing therapeutic approaches that increase healthspan and delay death. (2010) (14)
Restoring stem cells — all you need is NAD+ (2016) (14)
Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers (2020) (13)
Caloric restriction and life span determination of yeast cells. (2007) (13)
Dietary Restriction, Hormesis, and Small Molecule Mimetics (2005) (13)
Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice (2019) (13)
Can artificial intelligence identify effective COVID‐19 therapies? (2020) (12)
Synthesis and Assay of SIRT1-Activating Compounds. (2016) (12)
Impact papers on aging in 2009 - eScholarship (2010) (11)
The longevity of sirtuins. (2012) (11)
Yeast aging research: recent advances and medical relevance (1999) (10)
An unSIRTain role in longevity (2011) (10)
Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment (2020) (10)
Combining a high dose of metformin with the SIRT1 activator, SRT1720, reduces lifespan in aged mice fed a high-fat diet. (2020) (10)
Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease (2017) (9)
Molecular and Cellular Characterization of SIRT1 Allosteric Activators. (2019) (9)
Nicotinamide mononucleotide (NMN) deamidation by the gut microbiome and evidence for indirect upregulation of the NAD+metabolome (2020) (9)
An Age of Instability (2003) (9)
Sirtuins in Aging and Age-Related Diseases (2011) (9)
Evaluation research on results-based financing. An annotated bibliography of health science literature on RBF indicators for reproductive maternal newborn child and adolescent health. (2017) (9)
Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide (2018) (9)
HARVARD HIV AND AGING WORKSHOP: PERSPECTIVES AND PRIORITIES FROM CLAUDE D. PEPPER CENTERS AND CENTERS FOR AIDS RESEARCH. (2019) (9)
Sir 2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog 1 stress-activated protein kinase (2011) (8)
Erratum: The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice (Cell Metabolism (2014) 19(3) (418–430), (S1550413114000655), (10.1016/j.cmet.2014.02.009)) (2020) (8)
SIRT2 controls the pentose phosphate switch (2014) (8)
The elusive NMN transporter is found (2019) (7)
Ultra-cheap and scalable epigenetic age predictions with TIME-Seq (2021) (7)
The British constitution in 1997-98: Labour's constitutional revolution (1999) (6)
Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice (2020) (6)
MACHINE LEARNING ANALYSIS OF MOUSE FRAILTY FOR PREDICTION OF BIOLOGICAL AGE AND LIFE EXPECTANCY (2019) (6)
Sirtuin 1 Over-Expression Does Not Impact Retinal Vascular and Neuronal Degeneration in a Mouse Model of Oxygen-Induced Retinopathy (2013) (6)
The Aging Liver and the Effects of Long Term Caloric Restriction (2010) (6)
Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of MnSOD via the SIRT1/FoxO3a Pathway (2013) (5)
Cell biology. An age of instability. (2003) (5)
NAD+ repletion rescues female fertility during reproductive ageing (2019) (5)
Extracellular Vesicles for the Treatment of Radiation-Induced Normal Tissue Toxicity in the Lung (2021) (5)
Assays for NAD+-Dependent Reactions and NAD+ Metabolites. (2018) (4)
Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila (2020) (4)
Meeting Report: Aging Research and Drug Discovery (2022) (4)
Reduced Levels of NAD in Skeletal Muscle and Increased Physiologic Frailty Are Associated With Viral Coinfection in Asymptomatic Middle-Aged Adults (2022) (4)
Yeast RecQ Helicases: Clues to DNA Repair, Genome Stability and Aging (2013) (3)
Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice (2021) (3)
Sirtuin Evolution at the Dawn of Animal Life (2022) (3)
Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice. (2022) (3)
Novel feature selection methods for construction of accurate epigenetic clocks (2022) (2)
NAD+ DEPLETION AS A CAUSE OF INFLAMMAGING (2018) (2)
SIRT1 Deacetylase Is Essential for Hematopoietic Stem Cell Activity Via Regulation of Foxo3. (2012) (2)
Preliminary observations on the role of Sirtuin genes in grapevine (Vitis vinifera L.) Physiology (2014) (2)
Correction: Nicotinamide Impairs Entry into and Exit from Meiosis I in Mouse Oocytes (2015) (2)
Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1 (2019) (2)
Sirtuin Activation by Small Molecules (2016) (2)
The British constitution in 1998-99: the continuing revolution (2000) (2)
Nicotinamide mononucleotide (NMN) deamidation and indirect regulation of the NAD metabolome (2020) (1)
IN VIVO CELLULAR REPROGRAMMING FOR TISSUE REGENERATION AND AGE REVERSAL (2018) (1)
Publisher Correction: Age and life expectancy clocks based on machine learning analysis of mouse frailty (2020) (1)
Measuring PGC-1α and its acetylation status in mouse primary myotubes. (2015) (1)
Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload (2022) (1)
TIME-Seq Enables Scalable and Inexpensive Epigenetic Age Predictions (2022) (1)
Sir 2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog 1 SAPK (2011) (1)
Pharmacological Approaches for Modulating Sirtuins (2018) (1)
NMN Rescues Endothelial Function and Neurovascular Coupling, Improving Cognitive Function in Aged Mice (2020) (1)
The British Constitution: Labour’s Constitutional Revolution (2000) (1)
Is DNA cut out for a long life? (2003) (1)
Constitutional futures: transforming the UK’s political landscape (1999) (1)
Measuring PGC-1α and Its Acetylation Status in Mouse Primary Myotubes. (2021) (1)
The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function (2020) (1)
New insights into the roles of sirtuins in metabolic decline and disease of aging (2012) (1)
Plant cell cultures for the production of health promoting metabolites (2015) (1)
Reversal of aging-induced and glaucoma-induced vision loss by in vivo epigenetic reprogramming (2020) (1)
NMN Supplementation Rescues Fertility and Bone Strength in Chemotherapy-Treated Mice (2022) (0)
NAD PRECURSORS AS INTERVENTIONS FOR AGE-RELATED DISEASES AND EXTENDING HUMAN HEALTHSPAN (2017) (0)
Preliminary observations on the role of sirtuin genes in grapevine physiology. (2010) (0)
Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload (2021) (0)
Plant-Based Diets and Longevity (2020) (0)
Dynamic acetylation of cytosolic phosphoenolpyruvate carboxykinase toggles enzyme activity between gluconeogenic and anaplerotic reactions (2018) (0)
Have you seen ? SIRT 2 controls the pentose phosphate switch (2014) (0)
USING PROTEOMICS TO ELUCIDATE HOW VOLUNTARY EXERCISE COMBATS AGING PHENOTYPES IN MTDNA MUTATOR MICE (2018) (0)
SIRT1’s Role in Adipocyte Hyperplasia (2015) (0)
Resveratrol Induces Erythroid Maturation by Activating FOXO3 and Improves in Vivo Erythropoiesis in Normal and Beta -Thalassemic Mice (2012) (0)
Impact papers on aging in 2009 Citation (2022) (0)
Abstract 216: Novel assays for Sirtuin and PARP families utilizing unmodified substrates (2012) (0)
DISCOVERY OF A NOVEL CIRCULATING PEPTIDOME IN HUMAN SERUM THAT CORRELATES WITH AGING (2018) (0)
UNCOVERING THE CONNECTION BETWEEN GENOMIC AND EPIGENOMIC STABILITY DURING AGING WITH EXOGENOUS DNA REPAIR PROTEINS. (2018) (0)
Applying the AFRAID and FRIGHT Clocks to Novel Preclinical Mouse Models of Polypharmacy (2022) (0)
Final evaluation of the Saving Mothers and Newborns in Communities Project. A focused strategic assessment of a community midwives program in three districts of Balochistan province Pakistan. CSHGP Cooperative Agreement Number: AID-OAA-A-12-00093. Testing interventions to strengthen a private-sector (2016) (0)
A Saccaded Visual Transformer for General Object Spotting (2022) (0)
David A. Sinclair, Ph.D is interviewed by Vicki Glaser. (2008) (0)
Human Sirt2 in complex with SirReal2 and Ac-Lys-H3 peptide (2015) (0)
Figure 2, [Domains of Sgs1 and WRN...]. (2013) (0)
A NEW MOUSE MODEL TO UNRAVEL THE MECHANISM OF SIRT1 ACTIVATION (2018) (0)
Effects of High Fat Diet Induced Obesity on Mitochondrial Biogenesis and Function – Impact of Exercise or Nicotinamide Mononucleotide (NMN) (2015) (0)
Abstract P511: Sirtuin 5 Overexpression Protects Against Pressure Overload-Induced Ventricular Dysfunction (2021) (0)
MODULATING NUDIX HOMOLOGY DOMAIN (NHD) WITH NICOTINAMIDE MONONUCLEOTIDE ANALOGS AND DERIVATIVES OF SAME (2018) (0)
SIRT1 deacetylase is essential for hematopoietic stem cell activity (2013) (0)
Table 2, Properties of fungal RecQ helicases (2013) (0)
Extension of physical endurance and protection against physical, chemical and radiological trauma by NAD + precursors (2017) (0)
Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study. (2023) (0)
Methods and compositions to prolong the period of life and increase the resistance to stress of cells and organisms (2006) (0)
OL Longevity genes: parlor trick or path to drugs that revolutionize medicine (2010) (0)
MOLECULAR GENETICS OF AGING (2010) (0)
Sirtuin- cAMP crosstalk in metabolic diseases: nucleus versus mitochondria (2018) (0)
SIRT 1 expression , energy expenditure and insulin sensitivity SIRT 1 mRNA Expression May Be Associated with Energy Expenditure and Insulin Sensitivity Running title : SIRT 1 expression , energy expenditure and insulin sensitivity (2010) (0)
Galactic cosmic radiation exposure causes multifaceted neurocognitive impairments (2023) (0)
The possible role of the SIRT1 enzyme in oxidative stress and spindle assembly in bovine oocytes—a large animal model for reproductive ageing (2017) (0)
Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise (2017) (0)
Does Declining Mitochondrial NAD+ and Unscheduled Opening of Mitochondrial Transition Pore Promote Mammalian Aging? (2010) (0)
An examination of stress resistance and lifespan extension in the honey bee, Apis mellifera (2013) (0)
SIRT1 activator SRT3025 provides atheroprotection in ApoE/ mice by increasing hepatic LDL receptor (2019) (0)
LONG-LIVED ANIMAL MODELS AND HEALTH-SPAN EXTENSION IN STUDIES OF AGING (2017) (0)
Human Sirt2 in complex with ADP ribose and nicotinamide (2015) (0)
The elusive NMN transporter is found (2019) (0)
1 Negative Regulation of STAT 3-mediated Cellular Respiration by SirT 1 (2011) (0)
Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach (2017) (0)
Response to: "If the Metabolic Winter Is Coming, When Will It Be Summer?" (Metab Syndr Relat Disord 2017;15:3). (2017) (0)
Human Sirt2 in complex with SirReal1 and Ac-Lys-OTC peptide (2015) (0)
Sirtuins : emerging roles in cardiovascular and metabolic diseases Atherosclerosis : a chronic immunometabolic disease (2015) (0)
Nicotinamide mononucleotide (NMN) deamidation by host-microbiome interactions (2022) (0)
The 2021 FASEB science research conference on NAD metabolism and signaling (2021) (0)
Impaired blood glucose clearance and mitochondrial function induced by high fat diet is improved by exercise and an ‘exercise mimetic’ (2014) (0)
DNA Damage: Epigenetics, Aging and Rejuvenation (2020) (0)
The 15th Annual RAND Summer Institute Video (2009) (0)
Do antiaging approaches promote longevity (2005) (0)
Poly-Glutamine Induces Bax-Mediated Cell Death by Dissociating Ku70 from Bax through Ku70-Acetylation. (2005) (0)
Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy (2013) (0)
Dynamic Acetylation of Ph osphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions Graphical Abstract Highlights (2018) (0)
Human Sirt2 in complex with SirReal2 and NAD (2015) (0)
UNDERSTANDING WHY WE GROW OLD AS WE GROW OLDER (2018) (0)
All’s Well That Ages Well: The Economic Value of Targeting Aging∗ (2021) (0)
INVESTIGATING THE DNA DAMAGE RESPONSE AS A DRIVER OF EPIGENETIC CHANGE DURING AGING (2018) (0)
Metabolic Regulation of Gene Silencing and Life Span (2003) (0)
Methodes et compositions modulant l'apoptose faisant intervenir bax-ku70 (2005) (0)

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Lifespan: Why We Age - and Why We Don't Have To