Elias Arnér
Biochemist
Elias Arnér's AcademicInfluence.com Rankings
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Biology
Elias Arnér's Degrees
- Bachelors Chemistry Stockholm University
Why Is Elias Arnér Influential?
(Suggest an Edit or Addition)According to Wikipedia, Elias Arnér is a Swedish professor in biochemistry active in the fields of redox biology and cancer research. He studied medicine at Karolinska Institutet and became a medical doctor in 1997. He received his Ph.D. in 1993 from Karolinska Institutet on the subject of nucleoside analogues in relation to cancer and HIV treatment. He moved to Munich, Germany where he started focusing on selenoproteins. He returned to Karolinska Institutet where he became associate professor in 2000 and appointed professor in 2009. He is head of the biochemistry division in the department of medical biochemistry and biophysics at Karolinska Institutet. In 2017 he chairs the Se2017 – 200 Years of Selenium Research Conference.
Elias Arnér's Published Works
Published Works
- Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. (2001) (2629)
- Physiological functions of thioredoxin and thioredoxin reductase. (2000) (2364)
- Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis (2017) (669)
- Focus on mammalian thioredoxin reductases--important selenoproteins with versatile functions. (2009) (586)
- Mammalian deoxyribonucleoside kinases. (1995) (552)
- The thioredoxin system in cancer. (2006) (527)
- Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence. (2000) (456)
- Preparation and assay of mammalian thioredoxin and thioredoxin reductase. (1999) (314)
- Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target (2007) (302)
- Selenocysteine in proteins-properties and biotechnological use. (2005) (300)
- Rat and Calf Thioredoxin Reductase Are Homologous to Glutathione Reductase with a Carboxyl-terminal Elongation Containing a Conserved Catalytically Active Penultimate Selenocysteine Residue* (1998) (258)
- Selenoproteins-What unique properties can arise with selenocysteine in place of cysteine? (2010) (253)
- Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications. (2016) (245)
- High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes. (1999) (215)
- Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds. (2005) (212)
- A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems (2016) (202)
- Mammalian Thioredoxin Reductase Is Irreversibly Inhibited by Dinitrohalobenzenes by Alkylation of Both the Redox Active Selenocysteine and Its Neighboring Cysteine Residue* (1998) (196)
- The Mammalian Cytosolic Selenoenzyme Thioredoxin Reductase Reduces Ubiquinone (2003) (191)
- Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase. (1996) (189)
- Active sites of thioredoxin reductases: Why selenoproteins? (2003) (185)
- ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis (2014) (184)
- 1-Chloro-2,4-dinitrobenzene Is an Irreversible Inhibitor of Human Thioredoxin Reductase (1995) (181)
- TrxR1 as a potent regulator of the Nrf2-Keap1 response system. (2015) (180)
- Selenoprotein Gene Nomenclature* (2016) (177)
- Regulation of the mammalian selenoprotein thioredoxin reductase 1 in relation to cellular phenotype, growth, and signaling events. (2004) (177)
- Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex. (2001) (175)
- Rapid Induction of Cell Death by Selenium-compromised Thioredoxin Reductase 1 but Not by the Fully Active Enzyme Containing Selenocysteine* (2003) (167)
- Crystal Structure and Catalysis of the Selenoprotein Thioredoxin Reductase 1* (2009) (166)
- Cell Death by SecTRAPs: Thioredoxin Reductase as a Prooxidant Killer of Cells (2008) (155)
- Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues. (1992) (150)
- The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation. (2008) (150)
- Substrate specificity of mitochondrial 2'-deoxyguanosine kinase. Efficient phosphorylation of 2-chlorodeoxyadenosine. (1993) (147)
- Measurement of Thioredoxin and Thioredoxin Reductase (2005) (134)
- Interactions of Quinones with Thioredoxin Reductase (2003) (134)
- Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy (2018) (121)
- APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase (2013) (117)
- High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy. (2009) (115)
- Truncated Thioredoxin Is a Mitogenic Cytokine for Resting Human Peripheral Blood Mononuclear Cells and Is Present in Human Plasma* (2000) (115)
- Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning (2011) (113)
- Interactions of Nitroaromatic Compounds with the Mammalian Selenoprotein Thioredoxin Reductase and the Relation to Induction of Apoptosis in Human Cancer Cells* (2006) (113)
- Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase (2014) (110)
- Evidence for intriguingly complex transcription of human thioredoxin reductase 1. (2004) (103)
- Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis. (1993) (100)
- Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity (2009) (98)
- Expression of deoxycytidine kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues. (1995) (93)
- The Core Promoter of Human Thioredoxin Reductase 1 (2001) (93)
- Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors. (2011) (92)
- Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling (2013) (91)
- p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA (2009) (91)
- Assessment of Production Conditions for Efficient Use of Escherichia coli in High-Yield Heterologous Recombinant Selenoprotein Synthesis (2004) (88)
- Exploiting the 21st amino acid—purifying and labeling proteins by selenolate targeting (2004) (87)
- Noble metal targeting of thioredoxin reductase--covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin. (2010) (82)
- Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug. (2019) (82)
- Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver (2015) (81)
- Control of protein function through oxidation and reduction of persulfidated states (2020) (77)
- Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. (2009) (74)
- Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy. (1994) (73)
- Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1. (2012) (65)
- Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates. (2008) (65)
- Overexpression of Enzymatically Active Human Cytosolic and Mitochondrial Thioredoxin Reductase in HEK-293 Cells (2004) (63)
- Deoxycytidine kinase is constitutively expressed in human lymphocytes: consequences for compartmentation effects, unscheduled DNA synthesis, and viral replication in resting cells. (1988) (62)
- Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans (2011) (62)
- The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death (2014) (62)
- Adipose tissue morphology predicts improved insulin sensitivity following moderate or pronounced weight loss (2015) (60)
- Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER (2017) (58)
- A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification. (2013) (58)
- Multilevel Regulation of 2-Cys Peroxiredoxin Reaction Cycle by S-Nitrosylation* (2013) (56)
- NADPH-dependent and -independent disulfide reductase systems. (2018) (55)
- Thymidine and 3'-azido-3'-deoxythymidine metabolism in human peripheral blood lymphocytes and monocyte-derived macrophages. A study of both anabolic and catabolic pathways. (1992) (54)
- The Selenium-independent Inherent Pro-oxidant NADPH Oxidase Activity of Mammalian Thioredoxin Reductase and Its Selenium-dependent Direct Peroxidase Activities* (2010) (54)
- Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase (2017) (53)
- Thioredoxin reductase 1 is upregulated in atherosclerotic plaques: specific induction of the promoter in human macrophages by oxidized low-density lipoproteins. (2004) (52)
- Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells: implications for oxidant-induced lung injury. (2012) (52)
- Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase (2003) (52)
- The A to Z of modulated cell patterning by mammalian thioredoxin reductases (2018) (51)
- Chapter Five: Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy (2017) (51)
- Redox active motifs in selenoproteins (2014) (49)
- Induction of Cell Membrane Protrusions by the N-terminal Glutaredoxin Domain of a Rare Splice Variant of Human Thioredoxin Reductase 1*♦ (2008) (49)
- Recombinant expression of mammalian selenocysteine-containing thioredoxin reductase and other selenoproteins in Escherichia coli. (2002) (47)
- APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase (2013) (46)
- Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin (2020) (43)
- TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy (2019) (42)
- Selenocysteine Insertion at a Predefined UAG Codon in a Release Factor 1 (RF1)-depleted Escherichia coli Host Strain Bypasses Species Barriers in Recombinant Selenoprotein Translation* (2017) (42)
- Cross Talk in HEK293 Cells Between Nrf2, HIF, and NF-κB Activities upon Challenges with Redox Therapeutics Characterized with Single-Cell Resolution. (2017) (40)
- Tagging recombinant proteins with a Sel-tag for purification, labeling with electrophilic compounds or radiolabeling with 11C (2006) (40)
- Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities. (2016) (39)
- Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress. (2017) (39)
- Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1. (2014) (39)
- Human Protein Atlas of redox systems - what can be learnt? (2011) (37)
- Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5' untranslated region. (2000) (37)
- Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay. (2011) (35)
- Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness (2016) (35)
- Which Antioxidant System Shapes Intracellular H2O2 Gradients? (2019) (35)
- Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors (2016) (35)
- Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death (2020) (34)
- Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury. (2014) (33)
- Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase. (2012) (33)
- Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1. (2009) (32)
- On the phosphorylation of 2-chlorodeoxyadenosine (CdA) and its correlation with clinical response in leukemia treatment. (1996) (32)
- Thioredoxin Reductase Inhibition for Cancer Therapy. (2021) (32)
- Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades (2019) (32)
- Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures (2014) (31)
- Phosphorylation of 2‐chlorodeoxyadenosine (CdA) in extracts of peripheral blood mononuclear cells of leukaemic patients (1994) (31)
- The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death (2015) (31)
- Expression of selenocysteine-containing glutathione S-transferase in Escherichia coli. (2004) (31)
- HER2-Positive Tumors Imaged Within 1 Hour Using a Site-Specifically 11C-Labeled Sel-Tagged Affibody Molecule (2012) (31)
- Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure (2017) (31)
- System-wide identification and prioritization of enzyme substrates by thermal analysis (2021) (31)
- Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney. (2007) (30)
- Thioredoxin‐related protein of 14 kDa as a modulator of redox signalling pathways (2018) (29)
- The human thioredoxin reductase-1 splice variant TXNRD1_v3 is an atypical inducer of cytoplasmic filaments and cell membrane filopodia. (2009) (29)
- Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells (2017) (29)
- Abdominal subcutaneous adipose tissue cellularity in men and women (2017) (29)
- Superoxide production by dinitrophenyl‐ derivatized thioredoxin reductase ‐ a model for the mechanism and correlation to immunostimulation by dinitrohalobenzenes (1999) (29)
- Biochemical Discrimination between Selenium and Sulfur 1: A Single Residue Provides Selenium Specificity to Human Selenocysteine Lyase (2012) (29)
- Homozygous mutation in TXNRD1 is associated with genetic generalized epilepsy (2017) (28)
- Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance. (2016) (27)
- Selenium and selenoproteins in (redox) signaling, diseases, and animal models - 200 year anniversary issue. (2018) (26)
- Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells (2015) (26)
- Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1. (2009) (25)
- Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2 (2014) (24)
- Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: effects related to activity and Sec contents of thioredoxin reductase. (2012) (24)
- The thioredoxin system in cancer-introduction to a thematic volume of Seminars in Cancer Biology. (2006) (23)
- Selenolthiol and Dithiol C‐Terminal Tetrapeptide Motifs for One‐Step Purification and Labeling of Recombinant Proteins Produced in E. coli (2006) (23)
- Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate (2019) (22)
- Studies of an active site mutant of the selenoprotein thioredoxin reductase: the Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme. (2006) (21)
- Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase. (2020) (21)
- Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads (2016) (21)
- Correction: Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target (2007) (21)
- Wobble decoding by the Escherichia coli selenocysteine insertion machinery (2013) (20)
- The Rare TXNRD1_v3 (“v3”) Splice Variant of Human Thioredoxin Reductase 1 Protein Is Targeted to Membrane Rafts by N-Acylation and Induces Filopodia Independently of Its Redox Active Site Integrity* (2013) (20)
- Mitochondrial versus cytosolic activities of deoxyribonucleoside salvage enzymes. (1994) (20)
- Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system (2019) (19)
- Human Protein Atlas of Redox Systems — What Can Be Learnt? (2011) (19)
- Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping. (2013) (19)
- Characterization of lead compounds targeting the selenoprotein thioredoxin glutathione reductase for treatment of schistosomiasis. (2020) (18)
- Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. (2018) (17)
- A mouse model for in vivo tracking of the major dust mite allergen Der p 2 after inhalation (2005) (17)
- Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells. (2016) (16)
- Titration and Conditional Knockdown of the prfB Gene in Escherichia coli: Effects on Growth and Overproduction of the Recombinant Mammalian Selenoprotein Thioredoxin Reductase (2006) (16)
- Efficient selenocysteine-dependent reduction of toxoflavin by mammalian thioredoxin reductase. (2018) (16)
- Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif. (2021) (15)
- Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone (2019) (14)
- Combining [11C]-AnxA5 PET Imaging with Serum Biomarkers for Improved Detection in Live Mice of Modest Cell Death in Human Solid Tumor Xenografts (2012) (13)
- Biochemical Discrimination between Selenium and Sulfur 2: Mechanistic Investigation of the Selenium Specificity of Human Selenocysteine Lyase (2012) (13)
- Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically (2020) (12)
- Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin (2021) (12)
- Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms. (2016) (12)
- Perspectives of TrxR1-based cancer therapies (2020) (12)
- Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake (2016) (11)
- Deoxycytidine and 2',3'-dideoxycytidine metabolism in human monocyte-derived macrophages. A study of both anabolic and catabolic pathways. (1993) (11)
- Production and purification of homogenous recombinant human selenoproteins reveals a unique codon skipping event in E. coli and GPX4-specific affinity to bromosulfophthalein (2021) (10)
- To inhibit TrxR1 is to inactivate STAT3–Inhibition of TrxR1 enzymatic function by STAT3 small molecule inhibitors (2020) (10)
- ProPerDP: A Protein Persulfide Detection Protocol. (2019) (10)
- Effects of Mammalian Thioredoxin Reductase Inhibitors. (2020) (10)
- Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1,2-thiaselenane redox probe. (2021) (10)
- System-wide Identification of Enzyme Substrates by Thermal Analysis (SIESTA) (2018) (9)
- Common modifications of selenocysteine in selenoproteins. (2019) (9)
- Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death. (2013) (9)
- Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H2O2 Together with Bicarbonate (2021) (8)
- Overexpression of Recombinant Selenoproteins in E. coli. (2018) (7)
- Selective Evaluation of Thioredoxin Reductase Enzymatic Activities. (2018) (7)
- Development of therapies for rare genetic disorders of GPX4: roadmap and opportunities (2021) (7)
- Identification and targeting of selective vulnerability rendered by tamoxifen resistance (2020) (7)
- Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate (2020) (7)
- Simvastatin inhibits the core promoter of the TXNRD1 gene and lowers cellular TrxR activity in HepG2 cells. (2013) (7)
- Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress (2022) (7)
- Thioredoxin Reductase 1 as an Anticancer Drug Target (2016) (6)
- The 19 S Deubiquitinase Inhibitor bAP 15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death s (2014) (6)
- Selenium Metabolism in Herbivores and Higher Trophic Levels Including Mammals (2017) (6)
- History of Selenium Research (2011) (6)
- Maximal flux responses after multiple challenges with vasopressin. (1984) (4)
- Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus (2022) (4)
- Molecular Basis for the Interactions of Human Thioredoxins with Their Respective Reductases (2021) (3)
- Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases. (2022) (3)
- Special issue on selenoprotein expression and function. (2009) (3)
- Catabolism of deoxycytidine in human peripheral blood mononuclear cells and its interference with the determination of in situ thymidylate synthase activity. (1993) (3)
- Expressing recombinant selenoproteins using redefinition of a single UAG codon in an RF1-depleted E. coli host strain. (2022) (3)
- Thioredoxin reductase 1 (2005) (3)
- Comment on “Evidence that the ProPerDP method is inadequate for protein persulfidation detection due to lack of specificity” (2021) (2)
- Selenium utilization by GPX4 was an evolutionary requirement to prevent hydroperoxide-induced ferroptosis (2017) (2)
- The Interactions of Thioredoxin Reductase with Quinones and Acrolein: Covalent Adducts and Stimulation of NADPH Oxidase Activity (2010) (2)
- SIESTA as a universal unbiased proteomics approach for identification and prioritization of enzyme substrates (2021) (2)
- The Impact of Legalization of Sports Gambling: How Motivation, Fandom, and Gender Influence Sport-Related Consumption (2020) (2)
- Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation (2022) (2)
- Chelating agents regenerate mammalian thioredoxin reductase inhibited by mercury: Comparison with selenite effects on treatment of mercury poisoning (2011) (2)
- Bicarbonate is required for hydrogen peroxide-dependent inactivation of PTP1B in presence of the Trx system and peroxiredoxin (2018) (1)
- Thioredoxin related protein of 14 kDa (TRP14, TXNDC17) represses Nrf2 and NFκB activities and augments HIF activation (2018) (1)
- Rutin protects against endothelial dysfunction and induces nrf2-mediated adaptation in huvecs exposed to oxidative stress (2016) (1)
- Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides (2023) (1)
- Specific irreversible targeting of the selenoprotein thioredoxin reductase 1 in cancer therapy (2018) (1)
- Selenium research in biochemistry and biophysics - 200 year anniversary issue. (2018) (1)
- The selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1) as a main regulator of growth factor responses (2021) (1)
- Thioredoxin Reductase Inhibition Induces Nrf2mediated Antioxidant Responses in Murine Transformed Clara Cells (2011) (1)
- Division of Biochemistry Department of Medical Biochemistry and Biophysics Karolinska Institutet, Stockholm, Sweden (2009) (1)
- Site-speci fi cally 11 C-labeled Sel-tagged annexin A 5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death (2013) (0)
- Thioredoxin-related protein of 14 kDa may directly reduce protein cysteinylation motifs (2018) (0)
- The role of thioredoxin reductase 1 in cancer (2015) (0)
- The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1 (2023) (0)
- Development of a chemical probe that selectively images the activity of mammalian Thioredoxin Reductase 1 (2022) (0)
- Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system (2019) (0)
- Specific in vivo imaging of HER2-positive tumors within one hour using a site-specifically 11C-labeled Sel-tagged Affibody molecule (2011) (0)
- Molecular Mechanisms of Regulated Cell Pattering by the Mammalian Thioredoxin System (2017) (0)
- Ancient loss of catalytic selenocysteine spurred convergent adaptation in a mammalian oxidoreductase (2023) (0)
- Screening for novel inhibitors of glutathione peroxidase (2018) (0)
- TRP14 deficiency markedly reduces the inflammatory response in acute pancreatitis through Nrf2 activation (2021) (0)
- 84 - Thioredoxin Reductase 1 Directly Protects Protein Tyrosine Phosphatase 1B from Inactivation by H2O2 (2016) (0)
- Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate (2020) (0)
- The KELT Follow-Up Network and Transit False Positive Catalog: Pre-vetted False Positives for TESS (2018) (0)
- Construction of a ribonucleotide reductase R1 protein with an active site selenocysteine (2005) (0)
- Author Correction: Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system (2019) (0)
- Crystal structure of recombinant rat selenoprotein thioredoxin reductase 1 with oxidized C-terminal tail (2008) (0)
- H2O2, Thioredoxin, and Signaling (2017) (0)
- Biotechnology of selenocysteine (2006) (0)
- The Trp114 residue of thioredoxin reductase 1 is an electron relay sensor for oxidative stress (2014) (0)
- Redox pioneer: Professor Arne Holmgren. (2011) (0)
- Selenocysteine Insertion and Reactivity: Mammalian Thioredoxin Reductases in Relation to Cellular Redox Signaling (2003) (0)
- Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically (2022) (0)
- The selenoprotein thioredoxin reductase as a key regulator of cellular signaling pathways (2013) (0)
- Introduction to the Executive Editors (2009) (0)
- The major dust mite allergen Der p 2 is differentially distributed after intratracheal delivery in sensitised and non-sensitised mice (2004) (0)
- Identification and targeting of selective vulnerability rendered by tamoxifen resistance (2020) (0)
- Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation (2021) (0)
- Abstracts of Poster Presentations (2004) (0)
- In Memoriam Arne Holmgren (1940–2020) (2021) (0)
- Evaluation of dithiothreitol-oxidizing capacity (DOC) as a serum biomarker for chronic hepatitis B in patients exhibiting normal alanine aminotransferase levels: a pilot study towards better monitoring of disease (2021) (0)
- Procedes et moyens destines a l'expression de la selenoproteine (2000) (0)
- Single vs. Multiple Signage: Applying Limited Capacity Message Processing to Fan’s Recognition and Recall of In-stadium Advertising (2022) (0)
- BBA General Subjects – Changing of the Guard at the Publishing Palace (2013) (0)
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