Eline Slagboom
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Biology
Eline Slagboom's Degrees
- PhD Biomedical Sciences Leiden University
- Masters Biomedical Sciences Leiden University
- Bachelors Biomedical Sciences Leiden University
Why Is Eline Slagboom Influential?
(Suggest an Edit or Addition)According to Wikipedia, P. Eline Slagboom is a Dutch biologist specializing in the human familial longevity and ageing. Education Slagboom attended Christelijk Lyceum in Delft, graduating in 1978, before continuing to Leiden University for her Bachelors and Masters degrees in biology, followed by a Ph.D. focusing on Genomic Instability and Aging from the same institution.
Eline Slagboom's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Genetic studies of body mass index yield new insights for obesity biology (2015) (3549)
- Persistent epigenetic differences associated with prenatal exposure to famine in humans (2008) (2767)
- Defining the role of common variation in the genomic and biological architecture of adult human height (2014) (1805)
- New genetic loci link adipose and insulin biology to body fat distribution (2014) (1227)
- DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. (2009) (1112)
- Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture (2012) (1045)
- Genetic determination of telomere size in humans: a twin study of three age groups. (1994) (762)
- Identification of seven loci affecting mean telomere length and their association with disease (2013) (761)
- Whole-genome sequence variation, population structure and demographic history of the Dutch population (2014) (650)
- Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity (2016) (634)
- Facing up to the global challenges of ageing (2018) (538)
- The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2015) (532)
- Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population. (2011) (483)
- DNA methylation signatures link prenatal famine exposure to growth and metabolism (2014) (476)
- Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA (2016) (471)
- Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals (2012) (459)
- Periconceptional Maternal Folic Acid Use of 400 µg per Day Is Related to Increased Methylation of the IGF2 Gene in the Very Young Child (2009) (457)
- Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis (2018) (451)
- The transcriptional landscape of age in human peripheral blood (2015) (450)
- Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (2018) (417)
- Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study (2012) (382)
- Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect (2013) (375)
- The continuing value of twin studies in the omics era (2012) (351)
- Genome-wide patterns and properties of de novo mutations in humans (2015) (345)
- Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study (2006) (342)
- L1 drives IFN in senescent cells and promotes age-associated inflammation (2019) (342)
- Disease variants alter transcription factor levels and methylation of their binding sites (2015) (341)
- Identification of context-dependent expression quantitative trait loci in whole blood (2016) (332)
- Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology (2010) (328)
- Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa (2019) (314)
- Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers (2013) (307)
- The impact of low-frequency and rare variants on lipid levels (2015) (300)
- Telomere length predicts survival independent of genetic influences (2007) (299)
- Reduced insulin/IGF‐1 signalling and human longevity (2005) (295)
- Genome-wide association scan for five major dimensions of personality (2010) (288)
- A genome-wide association study of anorexia nervosa (2014) (284)
- Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression (2021) (284)
- Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited (2011) (273)
- Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs (2012) (269)
- Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. (2007) (267)
- The Genome of the Netherlands: design, and project goals (2013) (260)
- Genetic and environmental influences interact with age and sex in shaping the human methylome (2016) (260)
- Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study (2009) (255)
- Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels (2018) (246)
- The epigenome: Archive of the prenatal environment (2009) (241)
- Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age (2014) (238)
- Zygosity diagnosis in young twins by parental report (2000) (236)
- GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. (2015) (229)
- Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array (2013) (225)
- Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes. (2006) (224)
- The Adult Netherlands Twin Register: Twenty-Five Years of Survey and Biological Data Collection (2013) (222)
- Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. (2018) (221)
- Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock (1999) (220)
- Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. (2008) (220)
- Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. (2015) (216)
- A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. (2010) (210)
- Variation in the human TP53 gene affects old age survival and cancer mortality1 (2005) (209)
- Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins (2014) (207)
- Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. (2009) (203)
- High-yield noninvasive human genomic DNA isolation method for genetic studies in geographically dispersed families and populations. (1995) (200)
- DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood (2018) (198)
- N-glycomic biomarkers of biological aging and longevity: A link with inflammaging (2013) (195)
- A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function (2013) (193)
- A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility. (2008) (192)
- The number of p16INK4a positive cells in human skin reflects biological age (2012) (188)
- LINE-1 derepression in senescent cells triggers interferon and inflammaging (2018) (182)
- A whole genome association study of neuroticism using DNA pooling (2008) (181)
- The Netherlands Twin Register Biobank: A Resource for Genetic Epidemiological Studies (2010) (179)
- MARK-AGE biomarkers of ageing (2015) (179)
- Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels (2015) (179)
- Genome‐wide linkage analysis for human longevity: Genetics of Healthy Aging Study (2013) (174)
- A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer. (2003) (171)
- Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis in siblings with multiple joint involvement: the GARP study (2004) (168)
- Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans. (2011) (167)
- Two subsets of human alphoid repetitive DNA show distinct preferential localization in the pericentric regions of chromosomes 13, 18, and 21. (1986) (166)
- Small nucleoli are a cellular hallmark of longevity (2017) (164)
- Heritabilities of radiologic osteoarthritis in peripheral joints and of disc degeneration of the spine. (1999) (163)
- Hallmark Features of Immunosenescence Are Absent in Familial Longevity (2010) (160)
- A meta-analysis of genome-wide association studies identifies multiple longevity genes (2019) (158)
- Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study (2013) (157)
- Blood lipids influence DNA methylation in circulating cells (2016) (156)
- Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 (2010) (156)
- The Trans-Ancestral Genomic Architecture of Glycemic Traits (2020) (151)
- Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits (2017) (149)
- Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels (2016) (147)
- Genes Involved in the Osteoarthritis Process Identified through Genome Wide Expression Analysis in Articular Cartilage; the RAAK Study (2014) (147)
- Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity (2010) (146)
- A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p. (2005) (146)
- Netherlands twin family study of anxious depression (NETSAD). (2000) (144)
- Prenatal Famine and Genetic Variation Are Independently and Additively Associated with DNA Methylation at Regulatory Loci within IGF2/H19 (2012) (143)
- DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age (2011) (141)
- Heritabilities of apolipoprotein and lipid levels in three countries. (2002) (140)
- A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals (2019) (139)
- Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits (2018) (139)
- Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI (2015) (139)
- A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. (2010) (139)
- Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits (2018) (139)
- Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis (2011) (138)
- VDR gene variants associate with cognitive function and depressive symptoms in old age (2009) (137)
- Mental Performance in Old Age Dependent on Cortisol and Genetic Variance in the Mineralocorticoid and Glucocorticoid Receptors (2007) (137)
- Novel loci and pathways significantly associated with longevity (2016) (136)
- Genome-wide association study of smoking initiation and current smoking. (2009) (136)
- Reduced Response to Activated Protein C Is Associated with Increased Risk for Cerebrovascular Disease (1996) (134)
- Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. (2005) (133)
- A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip (2013) (132)
- Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study (2010) (131)
- MethylAid: visual and interactive quality control of large Illumina 450k datasets (2014) (130)
- Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes (2012) (129)
- Effects of a Web-Based Intervention on Physical Activity and Metabolism in Older Adults: Randomized Controlled Trial (2013) (129)
- Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic β-Cell Function (2009) (128)
- Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome (2015) (128)
- Lipidomics of familial longevity (2013) (127)
- Quantitative comparison of mRNA levels in mammalian tissues: 28S ribosomal RNA level as an accurate internal control. (1989) (126)
- GWAS for executive function and processing speed suggests involvement of the CADM2 gene (2016) (125)
- Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation (2020) (125)
- Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31 (2014) (125)
- ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age (2006) (124)
- Familial longevity is marked by enhanced insulin sensitivity (2011) (122)
- What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? (2005) (121)
- Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations (2015) (120)
- Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region (2012) (118)
- Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies (2014) (117)
- Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation (2018) (117)
- A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts (2012) (117)
- Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip. (2004) (117)
- Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity (2017) (117)
- Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age (2007) (116)
- Familial longevity is associated with decreased thyroid function. (2010) (115)
- Genes encoding longevity: from model organisms to humans (2008) (115)
- Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects (2012) (114)
- RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage (2018) (113)
- Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies (2018) (113)
- Characteristics of de novo structural changes in the human genome (2015) (113)
- Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk. (2019) (113)
- Decreased Levels of Bisecting GlcNAc Glycoforms of IgG Are Associated with Human Longevity (2010) (113)
- Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways (2011) (112)
- Gene expression analysis of mTOR pathway: association with human longevity (2013) (108)
- Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms (2016) (106)
- Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception (2018) (106)
- Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study (2005) (106)
- A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots. (2015) (104)
- Genome-wide association study of plasma lipids (2019) (103)
- Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children (2013) (101)
- Genetics of Healthy Aging in Europe (2007) (101)
- Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health (2017) (99)
- Identifying the genomic determinants of aging and longevity in human population studies: Progress and challenges (2013) (98)
- Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches (2014) (98)
- A high-quality human reference panel reveals the complexity and distribution of genomic structural variants (2016) (96)
- Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. (2010) (96)
- The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific (2013) (95)
- Associations between age and gray matter volume in anatomical brain networks in middle-aged to older adults (2014) (94)
- Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction (2019) (94)
- Osteoarthritis susceptibility genes influence the association between hip morphology and osteoarthritis. (2011) (93)
- Family Based Association Analyses between the Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Neuroticism, Anxiety and Depression (2007) (92)
- Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers (2014) (92)
- Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health. (2011) (90)
- SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study. (2007) (90)
- Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people (2012) (90)
- The CTRB1/2 Locus Affects Diabetes Susceptibility and Treatment via the Incretin Pathway (2013) (90)
- Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study (2010) (88)
- Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls (2020) (88)
- Progression of hand osteoarthritis over 2 years: a clinical and radiological follow-up study (2008) (87)
- Latent Infection with Cytomegalovirus Is Associated with Poor Memory CD4 Responses to Influenza A Core Proteins in the Elderly (2014) (87)
- New insights into osteoarthritis: early developmental features of an ageing-related disease (2008) (84)
- A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam study) (1998) (84)
- Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis. (2010) (84)
- Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations (2021) (83)
- Mobster: accurate detection of mobile element insertions in next generation sequencing data (2014) (83)
- Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits (2016) (82)
- Role of hormones in cartilage and joint metabolism: understanding an unhealthy metabolic phenotype in osteoarthritis (2012) (82)
- Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus. (2000) (81)
- Evidence from case–control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity (2013) (81)
- Genomics of human longevity (2011) (80)
- Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis (2014) (79)
- Lipid metabolism in long-lived families: the Leiden Longevity Study (2011) (78)
- Population-specific genotype imputations using minimac or IMPUTE2 (2015) (78)
- Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study. (2008) (78)
- Sequence heterogeneity within the human alphoid repetitive DNA family. (1986) (78)
- Linkage analysis of smoking initiation and quantity in Dutch sibling pairs (2004) (77)
- A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity (2019) (77)
- Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study. (2010) (76)
- Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis (2016) (76)
- Two-dimensional DNA fingerprinting of human individuals. (1989) (76)
- A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. (2016) (75)
- Human insulin/IGF-1 and familial longevity at middle age (2009) (75)
- Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis. (2014) (75)
- Activity limitations in the lower extremities in patients with osteoarthritis: the modifying effects of illness perceptions and mental health. (2006) (75)
- Skewed X-inactivation is common in the general female population (2018) (75)
- Skewed X-inactivation is common in the general female population (2018) (75)
- Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites. The GARP study. (2007) (74)
- Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length (2020) (74)
- Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: Cross sectional and longitudinal studies (2012) (72)
- Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation (2015) (72)
- Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects. (2000) (71)
- Messenger RNA levels and methlation patterns of GAPDH and β-actin genes in rat liver, spleen and brain in relation to aging (1990) (70)
- Human longevity and 11p15.5: a study in 1321 centenarians (2009) (69)
- Lipoprotein Particle Profiles Mark Familial and Sporadic Human Longevity (2006) (68)
- Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck (2016) (68)
- DNA Methylation Landscapes of Human Fetal Development (2015) (68)
- Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes. (2009) (68)
- Butyrylcholinesterase: association with the metabolic syndrome and identification of 2 gene loci affecting activity. (2006) (67)
- Genes expressed in blood link osteoarthritis with apoptotic pathways (2013) (66)
- Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction. (2012) (66)
- Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes (2019) (66)
- Design, measurement and processing of region-specific DNA methylation assays: the mass spectrometry-based method EpiTYPER (2015) (65)
- A metabolomic profile is associated with the risk of incident coronary heart disease. (2014) (65)
- The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males (2013) (64)
- Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults (2011) (63)
- A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7 q 22 (2010) (63)
- Association of the tumour necrosis factor α −308G/A polymorphism with the risk of diabetes in an elderly population-based cohort (2002) (63)
- Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues (2012) (60)
- Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process (2017) (60)
- Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism (2015) (60)
- Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand (2006) (60)
- Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases (2020) (60)
- A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium (2009) (59)
- Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis. (2009) (59)
- Age‐dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK‐AGE study (2016) (59)
- Innate production of tumour necrosis factor α and interleukin 10 is associated with radiological progression of knee osteoarthritis (2007) (59)
- Epigenetic Variation in Monozygotic Twins: A Genome-Wide Analysis of DNA Methylation in Buccal Cells (2014) (59)
- Association of the risk of osteoarthritis with high innate production of interleukin-1beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation. (2005) (58)
- Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency (2013) (58)
- Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations. (2009) (58)
- PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population[S] (2013) (57)
- The MC1R Gene and Youthful Looks (2016) (56)
- DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons (2015) (56)
- Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand (2017) (56)
- Cerebral small vessel disease genomics and its implications across the lifespan (2020) (56)
- Cerebral small vessel disease genomics and its implications across the lifespan (2020) (56)
- Mortality risk in men is associated with a common mutation in the methylenetetrahydrofolate reductase gene (MTHFR) (1999) (56)
- Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps (2009) (56)
- Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility (2010) (55)
- Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population (2021) (55)
- The Risk of Mortality and the Factor V Leiden Mutation in a Population-based Cohort (1998) (54)
- Literature-Based Genetic Risk Scores for Coronary Heart Disease: The Cardiovascular Registry Maastricht (CAREMA) Prospective Cohort Study (2012) (53)
- No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85‐plus Study (2002) (53)
- Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses (2011) (53)
- Short telomere length is associated with impaired cognitive performance in European ancestry cohorts (2017) (53)
- Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study. (1997) (53)
- Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality (2011) (53)
- Body mass index and alignment and their interaction as risk factors for progression of knees with radiographic signs of osteoarthritis. (2011) (52)
- Common gene variants, mortality and extreme longevity in humans (2000) (52)
- Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study (2015) (52)
- Markers of Endogenous Desaturase Activity and Risk of Coronary Heart Disease in the CAREMA Cohort Study (2012) (52)
- Amino acid profiling in urine by capillary zone electrophoresis - mass spectrometry. (2007) (51)
- Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study. (2010) (51)
- Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait (2019) (51)
- Systematic Discovery of Complex Indels in Human Cancers (2015) (50)
- Microstructural Brain Tissue Damage in Metabolic Syndrome (2014) (49)
- Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health* (2016) (48)
- Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R (2012) (48)
- Developmental determinants in non-communicable chronic diseases and ageing (2015) (48)
- Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project (2011) (48)
- Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies. (2006) (48)
- Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity (2016) (48)
- Selection for Genetic Variation Inducing Pro-Inflammatory Responses under Adverse Environmental Conditions in a Ghanaian Population (2009) (47)
- Transcriptional Associations of Osteoarthritis‐Mediated Loss of Epigenetic Control in Articular Cartilage (2015) (47)
- Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns (2018) (47)
- The place of genetics in ageing research (2012) (47)
- Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions (2005) (47)
- A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis (2014) (47)
- Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis (1999) (47)
- Genetic instability and aging: theories, facts, and future perspectives. (1989) (47)
- P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age. (2016) (46)
- Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. (2017) (46)
- FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians (2006) (46)
- Sex Differences in Genetic Associations With Longevity (2018) (46)
- Association of APOE e2/e3/e4 and Promoter Gene Variants With Dementia But Not Cardiovascular Mortality in Old Age (2002) (46)
- Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study (2006) (46)
- Historical demography and longevity genetics: Back to the future (2017) (46)
- Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp (2012) (45)
- Pharmacogenetics of statins: achievements, whole-genome analyses and future perspectives. (2012) (45)
- Genetic Variation in the Interleukin‐10 Gene Promoter and Risk of Coronary and Cerebrovascular Events (2007) (45)
- An Internet-Based Physical Activity Intervention to Improve Quality of Life of Inactive Older Adults: A Randomized Controlled Trial (2016) (44)
- Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family? (2005) (44)
- Targeted Biomarker Discovery by High Throughput Glycosylation Profiling of Human Plasma Alpha1-Antitrypsin and Immunoglobulin A (2013) (44)
- Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice (2017) (43)
- Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels (2015) (43)
- High serum glucose levels are associated with a higher perceived age (2011) (42)
- Interleukin-1 region meta-analysis with osteoarthritis phenotypes. (2010) (42)
- Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype (2008) (41)
- Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands. (2008) (41)
- LDL cholesterol still a problem in old age? A Mendelian randomization study. (2015) (41)
- Genetic Linkage and Association Analysis for Loneliness in Dutch Twin and Sibling Pairs Points to a Region on Chromosome 12q23–24 (2006) (41)
- Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein–protein interaction modules as robust markers of human aging (2013) (41)
- Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes? (2010) (40)
- Allelic variation at the C-reactive protein gene associates to both hand osteoarthritis severity and serum high sensitive C-reactive protein levels in the GARP study (2007) (39)
- DNA methylation signatures of educational attainment (2018) (39)
- Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2 (2014) (39)
- Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: a prospective longitudinal cohort study. (2007) (39)
- Association study of candidate genes for the progression of hand osteoarthritis. (2013) (39)
- Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals. (2013) (38)
- Heritability estimates for 361 blood metabolites across 40 genome-wide association studies (2020) (38)
- Iron deficiency and NRAMP1 polymorphisms (INT4, D543N and 3'UTR) do not contribute to severity of anaemia in tuberculosis in the Indonesian population. (2007) (38)
- Risk factors in familial osteoarthritis: the GARP sibling study. (2008) (38)
- Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2. (2016) (38)
- PASSion: a pattern growth algorithm-based pipeline for splice junction detection in paired-end RNA-Seq data (2012) (37)
- Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches (2019) (37)
- Insulin-like growth factor I gene promoter polymorphism, collagen type II α1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study (2004) (37)
- Genetics of Human Aging: The Search for Genes Contributing to Human Longevity and Diseases of the Old (2000) (37)
- Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2016) (37)
- Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals. (2019) (36)
- The 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth. (2007) (36)
- How to deal with the early GWAS data when imputing and combining different arrays is necessary (2011) (36)
- IL7R gene expression network associates with human healthy ageing (2015) (36)
- The Val66Met polymorphism of the BDNF gene in anorexia nervosa: New data and a meta-analysis (2013) (36)
- Eating disorders: from twin studies to candidate genes and beyond. (2005) (35)
- Aging as Accelerated Accumulation of Somatic Variants: Whole-Genome Sequencing of Centenarian and Middle-Aged Monozygotic Twin Pairs (2013) (35)
- Biogerontology: Mechanisms and Interventions (2007) (35)
- A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus (2013) (34)
- Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: risk of mortality and fatal cardiovascular disease in an elderly population-based cohort. (1999) (34)
- Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity (2017) (34)
- QTLs for height: results of a full genome scan in Dutch sibling pairs (2004) (34)
- Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas (2020) (34)
- IgG glycosylation and DNA methylation are interconnected with smoking. (2018) (34)
- Using ancestry-informative markers to identify fine structure across 15 populations of European origin (2014) (34)
- Phenome and genome based studies into human ageing and longevity: An overview. (2017) (34)
- Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels (2016) (34)
- Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study (2016) (33)
- CD226 (DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis (2014) (33)
- Integrating Protein-Protein Interaction Networks with Gene-Gene Co-Expression Networks improves Gene Signatures for Classifying Breast Cancer Metastasis (2011) (33)
- Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85 (1999) (33)
- Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines. (2015) (33)
- Genetic Variation in Pentraxin (PTX) 3 Gene Associates with PTX3 Production and Fertility in Women1 (2010) (33)
- Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age. (2002) (32)
- Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults (2019) (32)
- The effect of forced exercise on knee joints in Dio2−/− mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress (2014) (32)
- Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease (2019) (32)
- Genome-Wide Study of Gene Variants Associated with Differential Cardiovascular Event Reduction by Pravastatin Therapy (2012) (32)
- Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes (2006) (32)
- Genome-wide Linkage Scan to Identify Loci for Age at First Cigarette in Dutch Sibling Pairs (2006) (32)
- Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population (2003) (32)
- Variation in the SHC1 gene and longevity in humans 1 (2004) (31)
- Genetic linkage analysis of 14 candidate gene loci in a family with autosomal dominant osteoarthritis without dysplasia. (1997) (31)
- Meta-analysis of genome-wide association studies of HDL cholesterol response to statins (2016) (31)
- Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship. (2015) (31)
- Evidence for the association of the S100β gene with low cognitive performance and dementia in the elderly (2007) (31)
- Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence (2013) (31)
- C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age (2005) (30)
- No or only population-specific effect of PON1 on human longevity: A comprehensive meta-analysis (2010) (30)
- Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine (2019) (30)
- Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes (2012) (29)
- Sex Differences in Sum Scores May Be Hard to Interpret (2009) (29)
- Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour (2021) (29)
- Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study (2017) (29)
- Replicated Linkage for Eye Color on 15q Using Comparative Ratings of Sibling Pairs (2006) (29)
- Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression (2009) (29)
- Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations (2019) (28)
- Lower Susceptibility to Cerebral Small Vessel Disease in Human Familial Longevity: The Leiden Longevity Study (2013) (28)
- Relationship between genome and epigenome - challenges and requirements for future research (2014) (28)
- Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene. (2012) (28)
- Validated inference of smoking habits from blood with a finite DNA methylation marker set (2019) (27)
- Visceral adipose tissue is associated with microstructural brain tissue damage (2015) (27)
- Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval (2013) (27)
- Broad phenotype of cysteine-altering NOTCH3 variants in UK Biobank (2020) (27)
- Familial Longevity Is Marked by Lower Diurnal Salivary Cortisol Levels: The Leiden Longevity Study (2012) (27)
- Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis (2007) (27)
- ADHD in Dutch adults: Heritability and linkage study (2011) (27)
- The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis (2007) (26)
- Liver X receptor alpha associates with human life span. (2007) (26)
- Association study in eating disorders: TPH2 associates with anorexia nervosa and self‐induced vomiting (2011) (26)
- Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data (2012) (26)
- Metabolic effects of a 13-weeks lifestyle intervention in older adults: The Growing Old Together Study (2016) (26)
- Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-aged subjects predisposed to familial longevity. (2012) (25)
- Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults (2018) (25)
- Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations (2021) (25)
- Neo-cartilage engineered from primary chondrocytes is epigenetically similar to autologous cartilage, in contrast to using mesenchymal stem cells. (2016) (25)
- Non-response to (statin) therapy: the importance of distinguishing non-responders from non-adherers in pharmacogenetic studies (2015) (25)
- Association of common genetic variants with brain microbleeds (2020) (25)
- The complex genetics of gait speed: genome-wide meta-analysis approach (2017) (25)
- Activity recognition using wearable sensors for tracking the elderly (2020) (24)
- Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting (2019) (24)
- Familial Longevity Is Marked by Better Cognitive Performance at Middle Age: The Leiden Longevity Study (2013) (24)
- The Serotonin Transporter Gene Length Polymorphism (5-HTTLPR) and Life Events: No Evidence for an Interaction Effect on Neuroticism and Anxious Depressive Symptoms (2010) (24)
- Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study (2017) (24)
- Dose-Response Effects of a Web-Based Physical Activity Program on Body Composition and Metabolic Health in Inactive Older Adults: Additional Analyses of a Randomized Controlled Trial (2014) (24)
- Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci (2009) (24)
- Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains (2021) (24)
- Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity (2016) (24)
- Pro‐inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength (2013) (23)
- Periconception maternal smoking and low education are associated with methylation of INSIGF in children at the age of 17 months (2012) (23)
- Association between Several Clinical and Radiological Determinants with Long-Term Clinical Progression and Good Prognosis of Lower Limb Osteoarthritis (2011) (23)
- Impact of genetic variations in the WRN gene on age related pathologies and mortality (2006) (23)
- Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study (2019) (23)
- High microsatellite and SNP genotyping success rates established in a large number of genomic DNA samples extracted from mouth swabs and genotypes. (2006) (23)
- Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants (2014) (23)
- Genomic studies in ageing research: the need to integrate genetic and gene expression approaches (2008) (23)
- Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies (2010) (23)
- Doyle Index is a valuable additional pain measure in osteoarthritis. (2010) (23)
- Narrow-sense heritability estimation of complex traits using identity-by-descent information (2017) (22)
- The Caenorhabditis elegans genome contains monomorphic minisatellites and simple sequences. (1989) (22)
- Handgrip strength at midlife and familial longevity (2011) (22)
- Low mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study (2014) (22)
- Establishing a Twin Register: An Invaluable Resource for (Behavior) Genetic, Epidemiological, Biomarker, and ‘Omics’ Studies (2018) (22)
- Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study (2010) (21)
- Glucocorticoid receptor gene polymorphisms are associated with reduced first‐phase glucose‐stimulated insulin secretion and disposition index in women, but not in men (2012) (21)
- A linear mixed-model approach to study multivariate gene–environment interactions (2018) (21)
- Evidence for a role of the genomic region of the gene encoding for the alpha1 chain of type IX collagen (COL9A1) in hip osteoarthritis: A population-based study. (2005) (21)
- Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) (2011) (21)
- White Matter Lesion Progression: Genome-Wide Search for Genetic Influences (2015) (21)
- Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies (2019) (20)
- Familial longevity is characterized by high circadian rhythmicity of serum cholesterol in healthy elderly individuals (2016) (20)
- Abdominal fat accumulation in adults born preterm exposed antenatally to maternal glucocorticoid treatment is dependent on glucocorticoid receptor gene variation. (2011) (20)
- Blood Metabolomic Measures Associate With Present and Future Glycemic Control in Type 2 Diabetes (2018) (20)
- Response to Activated Protein C in Subjects with and without Dementia (1998) (20)
- Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease (2020) (20)
- Copy number variation associates with mortality in long‐lived individuals: a genome‐wide assessment (2015) (20)
- Non-Homologous End-Joining Pathway Associated with Occurrence of Myocardial Infarction: Gene Set Analysis of Genome-Wide Association Study Data (2013) (20)
- Annotating Transcriptional Effects of Genetic Variants in Disease‐Relevant Tissue: Transcriptome‐Wide Allelic Imbalance in Osteoarthritic Cartilage (2019) (20)
- Genome‐wide linkage scan in affected sibling pairs identifies novel susceptibility region for venous thromboembolism: Genetics In Familial Thrombosis study (2013) (20)
- Systematic Testing of Literature Reported Genetic Variation Associated with Coronary Restenosis: Results of the GENDER Study (2012) (19)
- The influence of clan structure on the genetic variation in a single Ghanaian village (2013) (19)
- A powerful and rapid approach to human genome scanning using small quantities of genomic DNA. (2001) (19)
- The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OA. (2009) (19)
- Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study (2009) (19)
- Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study (2011) (19)
- Hypothesis-free identification of modulators of genetic risk factors (2015) (19)
- Families in comparison: An individual-level comparison of life-course and family reconstructions between population and vital event registers (2020) (19)
- Secondary phenotype analysis in ascertained family designs: application to the Leiden longevity study (2016) (19)
- Automated quantification of metabolites in blood-derived samples by NMR. (2017) (19)
- Cerebral Microbleeds and Lacunar Infarcts Are Associated with Walking Speed Independent of Cognitive Performance in Middle-Aged to Older Adults (2016) (19)
- Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium (2015) (19)
- Longitudinal weight differences, gene expression, and blood biomarkers in BMI discordant identical twins (2015) (19)
- Cortisol serum levels in familial longevity and perceived age: The Leiden Longevity Study (2012) (18)
- Genetic variation in VTCN1 (B7-H4) is associated with course of disease in juvenile idiopathic arthritis (2013) (18)
- Metabolomic profiles predict individual multidisease outcomes (2022) (18)
- Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS (2022) (18)
- DNA methods for detecting and analyzing mutations in vivo. (1987) (18)
- Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana (2010) (18)
- A genome-wide association study identifies genetic loci associated with specific lobar brain volumes (2019) (18)
- Integrating metabolomics profiling measurements across multiple biobanks. (2014) (18)
- Genetics of osteoarthritis: early developmental clues to an old disease (2008) (18)
- The ApoE ε4 Isoform: Can the Risk of Diseases be Reduced by Environmental Factors? (2018) (18)
- Polymorphisms in proinflammatory genes and susceptibility to typhoid fever and paratyphoid fever. (2007) (18)
- Ambulant 24‐h glucose rhythms mark calendar and biological age in apparently healthy individuals (2013) (18)
- Lifestyle and youthful looks (2015) (18)
- Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference (2019) (17)
- Serum insulin‐like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross‐sectional study (2013) (17)
- Frailty in end-stage hip or knee osteoarthritis: validation of the Groningen Frailty Indicator (GFI) questionnaire (2017) (17)
- Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP 5 and STX 2 (2014) (17)
- Genetic influences on disordered eating behaviour are largely independent of body mass index (2008) (17)
- Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study (2012) (17)
- A whole-genome scan for 24-hour respiration rate: a major locus at 10q26 influences respiration during sleep. (2005) (17)
- Thyroid status and mortality in nonagenarians from long-lived families and the general population (2017) (16)
- Association of Thyroid Dysfunction With Cognitive Function (2021) (16)
- A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium (2016) (16)
- Genome-wide association study of circulating interleukin 6 levels identifies novel loci (2021) (16)
- Pathway Analysis Using Genome-Wide Association Study Data for Coronary Restenosis – A Potential Role for the PARVB Gene (2013) (16)
- Do senescence markers correlate in vitro and in situ within individual human donors? (2018) (16)
- Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance (2014) (16)
- Familial Resemblance for Serum Metabolite Concentrations (2013) (16)
- The Dynamics of Genome Organization and Expression during the Aging Process (1992) (16)
- Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study (2021) (16)
- A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention. (2011) (16)
- Organisation of the human genome and our tools for identifying disease genes (2002) (15)
- Genetic association analysis of RHOB and TXNDC3 in osteoarthritis. (2007) (15)
- Genetics and behavioral medicine: risk factors for cardiovascular disease. (1997) (15)
- Combined association and linkage analysis applied to the APOE locus (2004) (15)
- C-reactive protein and glucose regulation in familial longevity (2011) (15)
- A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-α levels (2010) (15)
- DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age (2016) (15)
- A genome wide association analysis in the GENDER study (2009) (15)
- The Leiden Family Lab study on Social Anxiety Disorder: A multiplex, multigenerational family study on neurocognitive endophenotypes (2018) (15)
- Identical twins carry a persistent epigenetic signature of early genome programming (2021) (15)
- A characterization of cis- and trans-heritability of RNA-Seq-based gene expression (2019) (14)
- Influence of Candidate Genes on Attention Problems in Children: A Longitudinal Study (2010) (14)
- Genetic association analysis of LARS2 with type 2 diabetes (2009) (14)
- Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors. (2005) (14)
- An alternative approach to multiple testing for methylation QTL mapping reduces the proportion of falsely identified CpGs (2015) (14)
- Vitamin D Receptor Gene Polymorphisms Have Negligible Effect on Human Height (2008) (14)
- Cortical phase changes measured using 7‐T MRI in subjects with subjective cognitive impairment, and their association with cognitive function (2016) (14)
- Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections (2008) (14)
- Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation (2018) (14)
- Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults (2020) (14)
- Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression (2022) (14)
- Genome-wide identification of directed gene networks using large-scale population genomics data (2017) (14)
- Weighted statistics for aggregation and linkage analysis of human longevity in selected families: The Leiden Longevity Study (2009) (14)
- Visit-to-visit lipid variability: Clinical significance, effects of lipid-lowering treatment, and (pharmaco) genetics. (2018) (13)
- Sex‐specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility (2014) (13)
- Further Evidence for a QTL Influencing Body Mass Index on Chromosome 7p from a Genome-wide Scan in Dutch Families (2004) (13)
- IBD sharing around the PPARG locus is not increased in dizygotic twins or their mothers (2001) (13)
- Large-scale pharmacogenomic study of sulfonylureas and the QT, JT, and QRS intervals: CHARGE Pharmacogenomics Working Group (2016) (13)
- Longevity Around the Turn of the 20th Century: Life-Long Sustained Survival Advantage for Parents of Today’s Nonagenarians (2018) (13)
- Further evidence for a QTL influencing body mass index on chromosome 7p from a genome-wide scan in Dutch families. (2004) (13)
- Metabolic health in families enriched for longevity is associated with low prevalence of hand osteoarthritis and influences OA biomarker profiles (2012) (13)
- Genome scanning by two‐dimensional DNA typing: The use of repetitive DNA sequences for rapid mapping of genetic traits (1991) (13)
- How to kickstart a national biobanking infrastructure – experiences and prospects of BBMRI-NL (2012) (13)
- Maternal and child cytokine relationship in early life is not altered by cytokine gene polymorphisms (2016) (13)
- Interleukin-1 gene cluster variants with innate cytokine production profiles and osteoarthritis in subjects from the Genetics, Osteoarthritis and Progression Study. (2010) (12)
- Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360) (2017) (12)
- Detecting dispersed duplications in high-throughput sequencing data using a database-free approach (2016) (12)
- Corrigendum: DNA methylation signatures link prenatal famine exposure to growth and metabolism (2015) (12)
- Integrating Protein-Protein Interaction Networks with Gene- Gene Co-Expression Networks improves Gene Signatures for Classifying Breast Cancer Metastasis (2011) (12)
- The effect of standardized food intake on the association between BMI and 1H-NMR metabolites (2016) (12)
- Repeat length variations in polyglutamine disease-associated genes affect body mass index (2018) (11)
- Twins and the fetal origins hypothesis: an application to growth data (2005) (11)
- Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum (2019) (11)
- Parental longevity correlates with offspring’s optimism in two cohorts of community-dwelling older subjects (2011) (11)
- Zinc-Induced Metallothionein in Centenarian Offspring From a Large European Population: The MARK-AGE Project (2018) (11)
- Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies (2020) (11)
- Homocysteine and Familial Longevity: The Leiden Longevity Study (2011) (11)
- Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies (2020) (11)
- Chronic inhibition of the respiratory chain in human fibroblast cultures: differential responses related to subject chronological and biological age. (2012) (11)
- Functional Changes of T-Cell Subsets with Age and CMV Infection (2021) (11)
- Combined Linkage and Association Analyses of the 124-bp Allele of Marker D2S2944 with Anxiety, Depression, Neuroticism and Major Depression (2006) (10)
- Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis (2010) (10)
- The multifaceted interplay between lipids and epigenetics (2016) (10)
- Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R (2012) (10)
- Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels (2003) (10)
- C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects (2011) (10)
- Blood biomarker score identifies individuals at high risk for severe COVID-19 a decade prior to diagnosis: metabolic profiling of 105,000 adults in the UK Biobank (2020) (10)
- Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes (2016) (10)
- Variation in the CBP gene involved in epigenetic control associates with cognitive function (2011) (9)
- Longevity Relatives Count score identifies heritable longevity carriers and suggests case improvement in genetic studies (2019) (9)
- Genetically determined prospect to become long-lived is associated with less abdominal fat and in particular less abdominal visceral fat in men. (2015) (9)
- Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses (2020) (9)
- Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian (2019) (9)
- Systematic Evaluation of Normalization Methods for Glycomics Data Based on Performance of Network Inference (2019) (9)
- mRNA levels and methylation patterns of the tyrosine aminotransferase gene in aging inbred rats (1990) (9)
- Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes (2017) (9)
- Transforming the future of ageing (2019) (9)
- Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER study (2008) (9)
- Brain tissue volumes in familial longevity: the Leiden Longevity Study (2012) (9)
- A characterization of postzygotic mutations identified in monozygotic twins (2018) (9)
- Prevalence and loads of torquetenovirus (TTV) in the European MARK-AGE Study population. (2019) (9)
- No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects (2014) (9)
- Genetic Variation at the TPH2 Gene Influences Impulsivity in Addition to Eating Disorders (2013) (9)
- The aging genome: determinant or target? Report of the EURAGE meeting on 'Genomic Instability and Aging', Nerja (Spain). (1990) (9)
- Association of Liver Enzymes and Computed Tomography Markers of Liver Steatosis with Familial Longevity (2014) (8)
- Author Correction: L1 drives IFN in senescent cells and promotes age-associated inflammation (2019) (8)
- Two subsets of human alphoid repetitive DNA show distinct preferential localization in the pericentromeric heterochromatin of chromosomes 13, 21 and 18 (1986) (8)
- 1H-NMR metabolomics-based surrogates to impute common clinical risk factors and endpoints (2021) (8)
- In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study. (2014) (8)
- Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes (2015) (8)
- Age, sex and BMI influence on copper, zinc and their major serum carrier proteins in a large European population including Nonagenarian Offspring from MARK-AGE study. (2021) (8)
- Survival analysis with delayed entry in selected families with application to human longevity (2018) (8)
- High Adiposity Is Associated With Higher Nocturnal and Diurnal Glycaemia, but Not With Glycemic Variability in Older Individuals Without Diabetes (2018) (7)
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- 2 Genetic Linkage and Association Analysis for Loneliness 3 in Dutch Twin and Sibling Pairs Points to a Region (2005) (0)
- Meta-analysis identi fi es loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide signi fi cance (2014) (0)
- WORLDWIDE GENOME-WIDE ASSOCIATION STUDY OF LONGEVITY (2017) (0)
- Metabolomic predictors of phenotypic traits can replace and complement measured clinical variables in population-scale expression profiling studies (2022) (0)
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- Ameta-analysis of 120 246 individuals identi fi es 18 new loci for fi brinogen concentration (2016) (0)
- Genetic association studies into anorexia nervosa (2008) (0)
- Corrigendum Familial Resemblance for Serum Metabolite Concentrations — Corrigendum (2013) (0)
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- C-reactive protein haplotypes and dispositional optimism in obese and non-obese subjects (2012) (0)
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- Thyroid hormone signalling in Osteoarthritis : early life events in late life disease (2017) (0)
- Evidence from case–control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity (2012) (0)
- Phenotypic and functional immune attributes predicting survival in very elderly people (47.7) (2012) (0)
- AGE-RELATED DNA METHYLATION CHANGES IN NORMAL AND OSTEOARTHRITIS CARTILAGE (2016) (0)
- Collagen genes and skeletal disorders (1993) (0)
- Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels (2018) (0)
- Increasing number of long-lived ancestors associates with up to a decade of healthspan extension and a healthy metabolomic profile in mid-life (2022) (0)
- I-15 MOLECULAR EPIDEMIOLOGY OF OSTEOARTHRITIS AND BIOMARKERS (2010) (0)
- Comparison of healthy and normative aging reveals a metabolic component in hand oa and oa biochemical marker profiles (2012) (0)
- Pseudocholinesterase: Association with the Metabolic Syndrome and Identification of 2 Gene Loci Affecting Activity (2006) (0)
- cohort study (the Rotterdam study) radiological osteoarthritis in a population-based A genetic association study of the IGF-1 gene and (2006) (0)
- Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease (2019) (0)
- 365 SNPS ASSOCIATED WITH NORMAL VARIATION IN ADULT HUMAN HEIGHT ARE NOT ASSOCIATED WITH OSTEOARTHRITIS SUSCEPTIBILITY (2008) (0)
- Epigenome-wide association study reveals CpG sites associated with thyroid function and regulatory effects on KLF9. (2023) (0)
- HEALTHY AGING, THE GENOME OF ELDERLY INDIVIDUALS AND THEIR ENVIRONMENT—THE LEIDEN LONGEVITY STUDY (2017) (0)
- Responses to Influenza A Core Proteins in the Associated with Poor Memory CD4 Latent Infection with Cytomegalovirus Is (2014) (0)
- PLIS: A metabolomic response monitor to a lifestyle intervention study in older adults (2022) (0)
- ' s response to reviews Title : Incident venous thrombotic events in the Prospective Study of Pravastatin in the Elderly at Risk ( PROSPER ) (2010) (0)
- Metabolic predictors of phenotypic traits can replace and complement measured clinical variables in transcriptome-wide association studies (2022) (0)
- To what extent is ageing genetic ? (2012) (0)
- Study design for the identification of loci affecting human longevity (1996) (0)
- Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies (2020) (0)
- Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa (2019) (0)
- Assessment of health status by molecular measures in middle-aged to old persons, ready for clinical use? (2016) (0)
- Biostatistics of high-throughput gene expression and haplotype analysis (2001) (0)
- The auToiMMune 4Q27 locus is associaTed WITh JuvenIle IDIoPAThIC ArThrITIs (2015) (0)
- Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity (2020) (0)
- The role of genetic factors in the etiology of osteoarthritis (1995) (0)
- No evidence for a locus influencing Lp(a) levels on chromosome 1 (2002) (0)
- subjects predisposed to familial longevity intramyocellular lipid accumulation in middle-aged Proton magnetic resonance spectroscopy shows lower (2012) (0)
- Facing up to the global challenges of ageing (2018) (0)
- A genome-wide association study identifies a common variant near the GRP22 gene as a new locus involved in prevalence and progression of osteoarthritis (2009) (0)
- Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (2018) (0)
- Phenotyping the brain in human familial longevity using MRI (2015) (0)
- P3-164 Association of the s100β gene with low cognitive performance and dementia in the elderly: A thoroughly genomic and transcriptomic analysis (2006) (0)
- The association of blood biomarkers with outcomes in older patients with solid tumors: a systematic review (2022) (0)
- University of Southern Denmark Copy number variation associates with mortality in long-lived individuals (2015) (0)
- C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects Nathaly Rius-OttenheimAnton J. M. de CraenJohanna M. Geleijnse • P. Eline SlagboomDaan KromhoutRoos C. van der Mast • Frans G. ZitmanRudi G. WestendorpErik J. Giltay (2012) (0)
- DNA methylation in humans: inter-individual variation and its correlation across 16 Loci (2008) (0)
- aBVF Predicts Knee OA Structural Progression (2012) (0)
- A novel life span regulating locus at chr13q34 influencing serum triiodothyronine level (2015) (0)
- Activity recognition using wearable sensors for tracking the elderly (2020) (0)
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- PS2 - 12. Effects of T2D and fasting glucose/insulin associated loci on insulin secretion stimulated by glucose, GLP-1 or arginine as measured by hyperglycaemic clamps (2012) (0)
- Genetic association analysis of 13 nuclear encoded mitochondrial candidate genes with type 2 diabetes: the DAMAGE study (2010) (0)
- Integrating Multiple Glycans and Genetic Data Using Joint Modeling Techniques : An Application in Leiden Longevity Study (2012) (0)
- THE EFFECT OF SEVERE EXERCISE ON KNEE-JOINTS : IDENTIFYING PATHWAYS INVOLVED IN CARTILAGE DEGRADATION PROCESSES FOLLOWING MECHANICAL STRESS (2014) (0)
- Meta-analysis identifies novel genes influencing levels of the potential OA biomarkers sCOMP and uCTX2 (2013) (0)
- IL7R gene expression network associates with human familial longevity (2014) (0)
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- A study protocol of external validation of eight COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting (2023) (0)
- A combined lifestyle intervention induces a sensitization of the blood transcriptomic response to a nutrient challenge (2021) (0)
- A RARE GENETIC VARIANT IN THE PLCG2 GENE IS ASSOCIATED WITH A REDUCED RISK OF ALL MAJOR TYPES OF DEMENTIA AND AN INCREASED RISK TO REACH AN EXTREMELY OLD AGE (2018) (0)
- Germ line and Somatic Characteristics of the Long-Lived Genome (2015) (0)
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- Antenatal Glucocorticoid Treatment and Polymorphisms in Glucocorticoid and Mineralocorticoid Receptor Genes are Associated with Long-Term Neurodevelopmental Outcomes in Preterm Survivors (2014) (0)
- The -2481C variant allele of the lysine acetyltransferase PCAF is associated with reduced vascular mortality. Results from three independent prospective studies (2010) (0)
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- 068 OSTEOARTHRITIS SUSCEPTIBILITY GENES ARE ASSOCIATED WITH VARIATIONS IN HIP MORPHOLOGY (2009) (0)
- Low mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study (2014) (0)
- The H63D mutation in the HFE gene predisposes to arthralgia, chondrocalcinosis, and osteoarthritis (2004) (0)
- GENERIC BIOMARKERS IN AGEING: TOOLS TO STUDY METABOLIC HEALTH AND RESPONSE TO INTERVENTIONS (2017) (0)
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- Biostatistiek van high-throughput genexpressie en haplotype analyse (2001) (0)
- Integrative approach uncover microRNA interactome dysregulation in osteoarthritis cartilage (2018) (0)
- Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes (2015) (0)
- CONFERENCE Collagen genes and skeletal disorders (1993) (0)
- cha p te r 9 genetic variation at the quaking locus associates with clinical restenosis after PcI and induces vascular smooth muscle cell dysfunction (2009) (0)
- Genome-wide linkage analysis for longevity in European nonagenarian siblings: Genetics of Healthy Ageing Study (GEHA). (2011) (0)
- Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait (2019) (0)
- The Ageing Syndrome (1992) (0)
- Author and Subject Index (1998) (0)
- Genetic contribution to blood pressure: heritability and linkage results from Dutch twin and sibling pairs. (2004) (0)
- Aging as Accelerated Accumulation of Somatic Variants (2013) (0)
- A gain of function mutation in TNFRSF11B causes osteoarthritis with chondrocalcinosis (2014) (0)
- THA/TKA PATIENTS ARE MORE PHYSICALLY ACTIVE THAN THE GENERAL POPULATION (2017) (0)
- University of Groningen Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families (2016) (0)
- Genomewide meta-analysis identifies loci associated with IGF-I and IGEBP-3 levels with impact on age-related traits (vol 15, pg 811, 2016) (2017) (0)
- Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity Authors (2016) (0)
- 357 THE ROLE OF PLASMA CYTOKINE LEVELS, C-REACTIVE PROTEIN AND SELENOPROTEIN S GENE VARIATION IN OSTEOARTHRITIS (2008) (0)
- LOCI ASSOCIATED WITH N-GLYCOSYLATION OF HUMAN IGG SHOW PLEIOTROPY WITH AUTOIMMUNE DISEASES AND HAEMATOLOGICAL CANCERS (2013) (0)
- Blood lipids influence DNA methylation in circulating cells (2016) (0)
- Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study (2021) (0)
- Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response (2023) (0)
- The association of mTOR and familial longevity in the blood transcriptome is not reflected in primary skin fibroblasts (2014) (0)
- DNA Processing, Aging, and Cancer (1991) (0)
- Genome-wide analysis of constitutional DNA methylation in familial melanoma (2020) (0)
- High-throughput immuno-affinity capturing procedure for targeted glycan-based biomarker discovery : application to AAT and IgA (2011) (0)
- The functional effects of DIO2 in an in-vitro model for chondrogenesis (2012) (0)
- The MC 1 R Gene and Yout hful Looks Highlights (2016) (0)
- Circulating levels of metabolic biomarkers of site-specific and sex-specific arterial calcification in the multi-cohort BBMRI setting (2020) (0)
- Subject Index Vol. 41, 1986 (2004) (0)
- New Methods for Detecting DNA Sequence Variation in Relation to Aging (1990) (0)
- Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits: Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project (2023) (0)
- Study to Establish Biomarkers of Human Ageing (2008) (0)
- Validating biomarkers and models for epigenetic inference of alcohol consumption from blood (2021) (0)
- Ageing and osteoarthritis: application of gerontological concepts; (1995) (0)
- A SNP panel for identification of DNA and RNA specimens (2018) (0)
- Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation (2018) (0)
- Gut microbiome changes due to sleep disruption in older and younger individuals: a case for sarcopenia? (2022) (0)
- Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation (2018) (0)
- C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects (2011) (0)
- Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas (2020) (0)
- Genetics of multifactorial diseases (2001) (0)
- Higher thyroid stimulating hormone leads to cardiovascular disease and an unfavorable lipid profile: EVidence from multi-cohort Mendelian randomization and metabolomic profiling (2021) (0)
- 297 A NON-SYNONYMOUS SNP IN GENE ASSOCIATED WITH SUSCEPTIBILITY TO SYMPTOMATIC OSTEOARTHRITIS (2007) (0)
- Absent in Familial Longevity Hallmark Features of Immunosenescence Are (2010) (0)
- Genes, Germs and Resources. The role of the family and the disease environment in mortality and longevity in the Netherlands, 1812-2015 (2014) (0)
- Author response: Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population (2021) (0)
- Oral presentations (2009) (0)
- Osteoarthritis subtypes show distinguished transcriptomic landscapes (2018) (0)
- Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS (2022) (0)
- 355 GENOME-WIDE ASSOCIATION STUDY TO IDENTIFY NEW GENES AND PATHWAYS CONFERRING RISK TO OA SUSCEPTIBILITY IN MULTIPLE JOINT LOCATIONS AS DEFINED IN THE GARP STUDY (2011) (0)
- Association between fat-soluble vitamins and self-reported health status: a cross-sectional analysis of the MARK-AGE cohort (2021) (0)
- Studies into epigenetic variation and its contribution to cardiovascular disease (2007) (0)
- Genes associated with osteoarthritis identified by microarray-analysis of whole blood samples link oa to apoptotic pathways (2012) (0)
- DIO2-deficient mice are protected against cartilage damage in a model of exercise-induced OA (2015) (0)
- Genome scan for quantitative traits involved in cardiovascular disease (1999) (0)
- Severe osteoarthritis of the hand associates with markers within the ALDH1A2 gene and with very rare variants at 1p31 (2017) (0)
- Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years (2017) (0)
- Epigenome-wide association reveals extensive perturbations in DNA methylation associated with adiposity and its adverse metabolic consequences. Authors (2015) (0)
- INNATE IMMUNITY IN FAMILIAL LONGEVITY - THE LEIDEN LONGEVITY STUDY (2012) (0)
- A review of QTL and knock-out studies for emotionality in mice (2001) (0)
- S202 A GENOME WIDE ASSOCIATION STUDY ON CHRONIC WIDESPREAD PAIN: EVIDENCE FOR INVOLVEMENT OF THE 5P15.2 REGION (2011) (0)
- Genome-wide identification of directed gene networks using large-scale population genomics data (2018) (0)
- ChaPteR 4 dna methylatiOn landscapes Of human fetal develOpment (2017) (0)
- Repeated measurements of uCTX-II, sCOMP, sPIIANP, uCTX-I, and hsCRP as biomarkers of progression or efficacy of intervention (2013) (0)
- Metabolomic predictors of phenotypic traits can replace and complement measured clinical variables in population-scale expression profiling studies (2022) (0)
- arthralgia, chondrocalcinosis and osteoarthritis gene predisposes to HFE The H63D variant in the (2007) (0)
- Is PLXNA2 a candidate gene for childhood and adult anxiety and depression (2007) (0)
- Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (2019) (0)
- A framework for the detection of de novo mutations in family-based sequencing data (2016) (0)
- A framework for the detection of de novo mutations in family-based sequencing data (2016) (0)
- DNA methylation signatures of educational attainment (2018) (0)
- DNA methylation signatures of educational attainment (2018) (0)
- Chapter 6 A gain of function mutation in TNFRSF 11 B causes osteoarthritis with chondrocalcinosis (2015) (0)
- identifies 148 independent genetic loci influencing general cognitive function Permalink (2018) (0)
- Cognitive function in old age but not mood is dependent on a ER22/23EK variation in the glucocorticoid receptor gene. The Leiden 85-plus Study. (2007) (0)
- Erratum: A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling (2017) (0)
- Genetics of Smoking and Nicotine Dependence - Session: Genetics of Nicotine Dependence (Symposium) (2004) (0)
- Supplementary Material 11 (2014) (0)
- Genetic Variation at the TPH2 Gene Influences Impulsivity in Addition to Eating Disorders (2012) (0)
- 375 LARGE-SCALE ASSOCIATION STUDY OF SUSCEPTIBILITY GENES FOR LUMBAR DISC HERNIATION (2009) (0)
- Linkage of the APOE locus with ApoE plasma levels in adolescent Dutch twins is completely explained by the APOE e2/e3/e4 alleles (2002) (0)
- Clarifying the biological and statistical assumptions of cross-sectional biological age predictors (2023) (0)
- Longitudinal variation of locus specific DNA methylation (2008) (0)
- DIO2 functions via T3: an in vitro model for chondrogenesis (2013) (0)
- Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health (2017) (0)
- TMAO and its precursors in relation to host genetics, gut microbial composition, diet, and clinical outcomes: Meta-analysis of 5 prospective population-based cohorts (2022) (0)
- No genetic determinants of differential cardiovascular event reduction by pravastatin in the PROSPER/PHASE study (2013) (0)
- Screening of eleven candidate genes from the 7p21.3 and Xq25 q26.3 linkage regions for association with venous thromboembolic risk: results from The Genetics In Familial Thrombosis (GIFT) Study (2009) (0)
- Epigenetic discordance in young, middle aged and old monozygotic twin pairs (2011) (0)
- A contemporary study into the functionality of Caspase 12 gene variants in rural Africa submitted for publication (0)
- Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms (2016) (0)
- Lipid and fatty acid metabolism: integrated analysis of genetic variation, biomarkers and environmental factors to identify new classifiers of incident MI risk and to maximize biological understanding. (2006) (0)
- Correction for both common and rare cell types in blood is important to identify genes that correlate with age (2021) (0)
- Correction for both common and rare cell types in blood is important to identify genes that correlate with age (2021) (0)
- A recurrent neural network architecture to model physical activity energy expenditure in older people (2022) (0)
- Association of metabolomics mortality score with geriatric assessment and mortality in older patients with solid tumors (2022) (0)
- THE arcOGEN CONSORTIUM: STAGE 1 OF A GENOME-WIDE ASSOCIATION SCAN FOR OSTEOARTHRITIS (2010) (0)
- Normal distribution of a single point-mutation in the factor V gene in patients with severe unstable angina pectoris (1995) (0)
- MMP9, an important mediator of vascular remodelling, and risk of restenosis after percutaneous coronary intervention (2005) (0)
- Genetic variations in the PCSK9 gene in relation to cholesterol levels, cognitive function and clinical events in an elderly population (2012) (0)
- This information is current as Elderly Responses to Influenza A Core Proteins in the Associated with Poor Memory CD 4 Latent Infection with Cytomegalovirus Is (2014) (0)
- Corrigendum to “A genome-wide association study identifies a common variant near the GPR22 gene as a new locus involved in prevalence and progression of osteoarthritis” [Bone. 44S2 (2009) S224] (2010) (0)
- The Prognostic Value of Metabolic Profiling in Older Patients With a Proximal Femoral Fracture (2020) (0)
- Phenotypic and functional immune attributes predicting survival in very elderly people (2012) (0)
- CHAPTER 5 POLYMORPHISMS IN TLR 4 AND TLR 2 GENES , CYTOKINE PRODUCTION AND SURVIVAL IN RURAL GHANA (2010) (0)
- P81 PATIENTSWITH AN INCREASED URINARY TYPE II COLLAGEN C-TELOPEPTIDE LEVELS HAVE AN ELEVATED RISK TO DEVELOP RADIOGRAPHIC PROGRESSION OF OSTEOARTHRITIS IN THE KNEE (2006) (0)
- University of Groningen A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function Porcu, (2013) (0)
- Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains (2021) (0)
- Chapter 7 Compelling insight into DIO 2 function during human in vitro chondrogenesis ; towards underlying mechanisms of OA susceptibility (2015) (0)
- Mendelian Randomization Causal Analysis LDL cholesterol still a problem in old age? A Mendelian randomization study (2015) (0)
- METABOLOMICS IN OSTEOARTHRITIS: A FATTY ACIDS LINK (2018) (0)
- replication in a wide range of sample collections gene 2 knee osteoarthritis genetic factor for Testing the druggable endothelial differentiation (2009) (0)
- Lymphotoxin-alpha polymorphism is a risk factor for stroke. The PROSPER study (2010) (0)
- Probing the articular cartilage transcriptome for genetic osteoarthritis susceptiblity (2015) (0)
- Biomarkers of the rate of ageing (2006) (0)
- Abstracts of the Online‐Only Articles (2012) (0)
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