Gerald Fischbach
American physician and neuroscientist
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(Suggest an Edit or Addition)According to Wikipedia, Gerald D. Fischbach is an American neuroscientist. He received his M.D. from the Weill Cornell Medical College of Cornell University in 1965 before beginning his research career at the National Institutes of Health in 1966, where his research focused on the mechanisms of neuromuscular junctions. After his tenure at the National Institutes of Health, Fischbach was a professor at Harvard University Medical School from 1972 to 1981 and from 1990 to 1998 and the Washington University School of Medicine from 1981 to 1990. In 1998, he was named the director of the National Institute of Neurological Disorders and Stroke before becoming the Vice President and Dean of the Health and Biomedical Sciences, the Dean of the Faculty of Medicine, and the Dean of the Faculty of Health Sciences at Columbia University from 2001 to 2006. Gerald Fischbach currently serves as the scientific director overseeing the Simons Foundation Autism Research Initiative. Throughout Fischbach's career, much of his research has focused on the formation and function of the neuromuscular junction, which stemmed from his innovative use of cell culture to study synaptic mechanisms.
Gerald Fischbach's Published Works
Published Works
- Rehabilitation of persons with traumatic brain injury. (1999) (831)
- Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation (1998) (689)
- The Simons Simplex Collection: A Resource for Identification of Autism Genetic Risk Factors (2010) (632)
- ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family (1993) (611)
- Neurotransmitters decrease the calcium conductance activated by depolarization of embryonic chick sensory neurones. (1981) (536)
- Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration. (1979) (529)
- Neuregulin and ErbB receptor signaling pathways in the nervous system (2001) (494)
- Glutamate receptor desensitization and its role in synaptic transmission (1989) (447)
- Synapse formation between dissociated nerve and muscle cells in low density cell cultures. (1972) (435)
- Early events in neuromuscular junction formation in vitro: induction of acetylcholine receptor clusters in the postsynaptic membrane and morphology of newly formed synapses (1979) (357)
- Acetylcholine release from growth cones detected with patches of acetylcholine receptor-rich membranes (1983) (345)
- ARIA: a neuromuscular junction neuregulin. (1997) (283)
- Maintenance of acetylcholine receptor number by neuregulins at the neuromuscular junction in vivo. (1997) (281)
- Changes in contractile properties of disused soleus muscles (1969) (262)
- The distribution of acetylcholine sensitivity over uninnervated and innervated muscle fibers grown in cell culture. (1973) (258)
- Induction of acetylcholine receptors on cultured skeletal muscle by a factor extracted from brain and spinal cord. (1979) (236)
- Differential expression of ARIA isoforms in the rat brain (1995) (223)
- Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex (2011) (189)
- Axonal Neuregulin Signals Cells of the Oligodendrocyte Lineage through Activation of HER4 and Schwann Cells through HER2 and HER3 (1997) (185)
- Mind and brain. (1992) (185)
- Purification and characterization of a polypeptide from chick brain that promotes the accumulation of acetylcholine receptors in chick myotubes (1986) (179)
- Failure of spinal cord oligodendrocyte development in mice lacking neuregulin. (1999) (176)
- A post‐natal decrease in acetylcholine channel open time at rat end‐plates. (1980) (171)
- Neuregulins Increase α7 Nicotinic Acetylcholine Receptors and Enhance Excitatory Synaptic Transmission in GABAergic Interneurons of the Hippocampus (2001) (160)
- The action potential of chick dorsal root ganglion neurones maintained in cell culture. (1977) (160)
- Regulation of acetylcholinesterase appearance at neuromuscular junctions in vitro (1980) (145)
- Acetylcholine receptor-inducing activity stimulates expression of the epsilon-subunit gene of the muscle acetylcholine receptor. (1991) (142)
- Rapid desensitization of glutamate receptors in vertebrate central neurons. (1988) (141)
- GABA conductance of chick spinal cord and dorsal root ganglion neurons in cell culture. (1981) (141)
- Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro (1986) (132)
- ARIA can be released from extracellular matrix through cleavage of a heparin-binding domain (1995) (129)
- Stem cells: science, policy, and ethics. (2004) (129)
- Chlordiazepoxide selectively potentiates GABA conductance of spinal cord and sensory neurons in cell culture. (1981) (124)
- A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity. (1991) (115)
- Future directions for epilepsy research (2001) (113)
- Elevated potassium induces morphological differentiation of dorsal root ganglionic neurons in dissociated cell culture. (1980) (109)
- Modulation of embryonic chick motoneuron glutamate sensitivity by interneurons and agonists (1986) (107)
- The Agrin/MuSK Signaling Pathway Is Spatially Segregated from the Neuregulin/ErbB Receptor Signaling Pathway at the Neuromuscular Junction (2000) (105)
- Isolation of embryonic chick motoneurons and their survival in vitro (1986) (104)
- Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing (2009) (100)
- Electrical properties of chick skeletal muscle fibers developing in cell culture (1971) (95)
- The Pattern of Cortical Dysfunction in a Mouse Model of a Schizophrenia-Related Microdeletion (2013) (93)
- A novel 87,000-Mr protein associated with acetylcholine receptors in Torpedo electric organ and vertebrate skeletal muscle (1989) (92)
- A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development. (1994) (91)
- Expression patterns of transmembrane and released forms of neuregulin during spinal cord and neuromuscular synapse development. (1999) (88)
- Rapid desensitization of glutamate receptors in vertebrate central neurons. (1988) (87)
- Neuregulin Expression at Neuromuscular Synapses Is Modulated by Synaptic Activity and Neurotrophic Factors (2002) (86)
- Acetylcholine receptor-inducing factor from chicken brain increases the level of mRNA encoding the receptor alpha subunit. (1988) (85)
- Electrophysiologic and morphologic properties of neurons in dissociated chick spinal cord cell cultures. (1974) (85)
- ARIA is concentrated in the synaptic basal lamina of the developing chick neuromuscular junction (1995) (85)
- Effect of chronic disuse of rat soleus neuromuscular junctions on presynaptic function. (1971) (75)
- ARIA, a protein that stimulates acetylcholine receptor synthesis, also induces tyrosine phosphorylation of a 185-kDa muscle transmembrane protein. (1993) (73)
- Uptake and release of [3H]gamma-aminobutyric acid by embryonic spinal cord neurons in dissociated cell culture (1979) (73)
- Neuregulin: An Oligodendrocyte Growth Factor Absent in Active Multiple Sclerosis Lesions (2001) (71)
- Effect of chronic disuse of rat soleus neuromuscular junctions on postsynaptic membrane. (1971) (71)
- The Neuregulin Precursor proARIA Is Processed to ARIA after Expression on the Cell Surface by a Protein Kinase C-Enhanced Mechanism (1998) (70)
- Evidence that coated vesicles transport acetylcholine receptors to the surface membrane of chick myotubes (1984) (70)
- Differential activation of myotube nuclei following exposure to an acetylcholine receptor-inducing factor (1989) (67)
- Clusters of acetylcholine receptors located at identified nerve-muscle synapses in vitro. (1977) (66)
- Neuregulin-1 increases the proliferation of neuronal progenitors from embryonic neural stem cells. (2005) (61)
- Mr 42,000 ARIA: a protein that may regulate the accumulation of acetylcholine receptors at developing chick neuromuscular junctions. (1990) (60)
- Enrichment of spinal cord cell cultures with motoneurons (1978) (60)
- Excitatory synaptic transmission between interneurons and motoneurons in chick spinal cord cell cultures (1986) (60)
- Neuregulin induces the expression of transcription factors and myosin heavy chains typical of muscle spindles in cultured human muscle. (2004) (57)
- Induction of acetylcholine receptor synthesis and aggregation: partial purification of low-molecular-weight activity. (1983) (55)
- Accumulation of acetylcholine receptors and acetylcholinesterase at newly formed nerve-muscle synapses. (1978) (54)
- A discontinuous relationship between the acetylcholine-activated channel conductance and temperature (1976) (54)
- Channel open time and metabolic stability of synaptic and extrasynaptic acetylcholine receptors on cultured chick myotubes. (1978) (54)
- A transition temperature for acetylcholine channel conductance in chick myoballs. (1978) (49)
- Clusters of intramembranous particles on cultured myotubes at sites that are highly sensitive to acetylcholine. (1978) (49)
- Neuregulin induces the rapid association of focal adhesion kinase with the erbB2-erbB3 receptor complex in schwann cells. (2000) (43)
- Accumulation of acetylcholinesterase at newly formed nerve--muscle synapases. (1979) (41)
- An Acute Effect of Neuregulin 1β to Suppress α7-Containing Nicotinic Acetylcholine Receptors in Hippocampal Interneurons (2006) (40)
- Acetylcholine receptors on chick mononucleated muscle precursor cells. (1978) (37)
- Formation of acetylcholine receptor clusters in chick myotubes: migration or new insertion? (1989) (35)
- Physiological and structural properties of colchicine-treated chick skeletal muscle cells grown in tissue culture. (1976) (35)
- Enrichment of nerve--muscle synapses in spinal cord--muscle cultures and identification of relative peaks of ACh sensitivity at sites of transmitter release. (1976) (35)
- The development of ACH- and GABA-activated currents in normal and target-deprived embryonic chick ciliary ganglia. (1990) (34)
- A voltage clamp study of the sodium, calcium and chloride spikes of chick skeletal muscle cells grown in tissue culture. (1976) (33)
- The distribution of acetylcholine receptor clusters and sites of transmitter release along chick ciliary ganglion neurite-myotube contacts in culture (1987) (33)
- GABA-mediated synaptic potentials in chick spinal cord and sensory neurons. (1981) (32)
- Acetylcholine noise in cultured chick myoballs: a voltage clamp analysis. (1978) (31)
- Muscarinic receptors and responses in intact embryonic chick atrial and ventricular heart cells. (1984) (30)
- ACh receptors accumulate at newly formed nerve-muscle synapses in vitro. (1977) (30)
- Type 3 reovirus neuroinvasion after intramuscular inoculation: direct invasion of nerve terminals and age-dependent pathogenesis. (2002) (30)
- NRG1 and Synaptic Function in the CNS (2007) (28)
- Changes in the number of chick ciliary ganglion neuron processes with time in cell culture (1987) (27)
- Calcium-dependent, slow desensitization distinguishes different types of glutamate receptors (1989) (25)
- Is there concordance in attitudes and beliefs between parents and scientists about autism spectrum disorder? (2016) (25)
- The Release of Acetylcholine Receptor Inducing Activity (ARIA) from Its Transmembrane Precursor in Transfected Fibroblasts* (1999) (23)
- Acetylcholine receptors of cultured muscle cells demonstrated with ferritin-alpha-bungarotoxin conjugates. (1974) (19)
- An acute effect of neuregulin 1 beta to suppress alpha 7-containing nicotinic acetylcholine receptors in hippocampal interneurons. (2006) (19)
- Processing of ARIA and release from isolated nerve terminals. (1999) (18)
- Differentiation-dependent regulation of skeletal myogenesis by neuregulin-1. (2003) (16)
- Neuregulin stimulates DNA synthesis in embryonic chick heart cells. (1999) (15)
- Peptide and amine transmitter effect on embryonic chick sensory neurons in vitro. (1981) (13)
- Schizophrenia: signals from the other side (2006) (12)
- Neuregulin-1 suppresses muscarinic receptor expression and acetylcholine-activated muscarinic K+ channels in cardiac myocytes. (2003) (12)
- A role for cAMP in the development of functional neuromuscular transmission. (1990) (11)
- Effects of eight neuropsychiatric copy number variants on human brain structure (2021) (11)
- A discussion of neuron and muscle cell cultures. (1973) (10)
- Acetylcholine receptor-inducing activity stimulates expression of the £-subunit gene of the muscle acetylcholine receptor ( neuron / neurotrophic / synapse / transcription / calcitonin gene-related peptide ) (10)
- Variation in the ratio of acetylcholine receptors and the Mr 43,000 receptor-associated protein in embryonic chick myotubes and myoblasts. (1990) (8)
- The different effect of neuromuscular inactivity and muscle atrophy on speed of contraction. (1970) (8)
- The Brain Doesn't Lie (2005) (7)
- Effect of enkephalin on sensory neurons in cell culture: inhibition of substance P release and reduction of inward calcium currents (1979) (5)
- Trophic interactions at developing synapses. (1994) (5)
- Variation among acetylcholine receptor clusters induced by ciliary ganglion neurons in vitro. (1988) (5)
- Neuroethicists Needed Now More Than Ever (2008) (4)
- The role of neuregulin (ARIA) at the neuromuscular junction. (1996) (4)
- Neuregulin effect on quantal content dissociated from effect on miniature endplate potential amplitude. (2006) (3)
- Molecular neurobiology. Mechanisms common to brain, skin and immune system. Proceedings of the International Symposium on Molecular Neurobiology. Tokyo, November 1992. (1994) (2)
- The Accumulation of Acetylcholine Receptors at Nerve—Muscle Synapses in Culture (1984) (1)
- Introduction. Where neuroscience has been and where it needs to go. (2000) (1)
- Ruggiu Agrin&Nova Supplementary PNAS2009 (2013) (0)
- The Effects of Neuregulin on Synapse Formation in Primary Muscle/Nerve Co-Cultures (2017) (0)
- Autism Spectrum Disorder, Developmental and Psychiatric Features in 16p11.2 Duplication (2016) (0)
- Cell Culture in Neurobiology (2011) (0)
- Ethics of Genetics in Research: and Promises (2006) (0)
- Neuregulin increases the proliferation of neuronal precursors in bFGF generated neural stem cells (2001) (0)
- Trophic functions of the neuron. I. Development of neural connections. Some observations of trophic interaction between neurons and muscle fibers in cell culture. (1974) (0)
- UPTAKE AND RELEASE OF (aH)y-AMINOBUTYR IC BY EMBRYONIC SPINAL CORD NEURONS IN DISSOCIATED CELL CULTURE ACID (1979) (0)
- Results ARIA Contains a Heparin-binding Domain Which When Bound to Heparin Blocks Receptor Phosphorylation (2002) (0)
- An introduction to molecular approaches in studies of neuronal development and synapse formation. (1987) (0)
- The accumulation of acetylcholine receptors at developing chick nerve-muscle samples (1989) (0)
- AMERICAN Mind and Brain The biological foundations of consciousness , memory and other attributes of mind (2008) (0)
- Modulation of Substance P Release and Voltage-Dependent Ion Channels in Primary Sensory Neurons (1982) (0)
- Workshop on hypoglycemia and the brain (2001) (0)
- Foreword (2004) (0)
- Special Topic Introduction: Neuronal Plasticity (1981) (0)
- 317 – A TRANSITION TEMPERATURE FOR ACETYLCHOLINE CHANNEL CONDUCTANCE IN CHICK MYOBALLS (1978) (0)
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