John Todd

Q: What Schools Are Affiliated With John Todd

John Todd is affiliated with the following schools: Imperial College London, University of Oxford, Stanford University, University of Edinburgh, University of Pittsburgh, University of Adelaide, Brigham Young University, University of Cambridge

John Todd 's AcademicInfluence.com Rankings

John Todd

Biology

#4612

World Rank

#6855

Historical Rank

Molecular Biology

#392

World Rank

#399

Historical Rank

Genetics

#401

World Rank

#466

Historical Rank

biology Degrees

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Biology

John Todd 's Degrees

PhD Genetics University of Oxford

Why Is John Todd Influential?

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According to Wikipedia, John Andrew Todd FMedSci FRS is Professor of Precision Medicine at the University of Oxford, director of the Wellcome Center for Human Genetics and the JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, in addition to Jeffrey Cheah Fellow in Medicine at Brasenose College. He works in collaboration with David Clayton and Linda Wicker to examine the molecular basis of type 1 diabetes.

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John Todd 's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (2007) (9208)
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease (2003) (2257)
HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus (1987) (1618)
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes (2007) (1471)
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants (2007) (1421)
A genome-wide search for human type 1 diabetes susceptibility genes (1994) (1342)
Haplotype tagging for the identification of common disease genes (2001) (1248)
Genome-wide association studies: theoretical and practical concerns (2005) (1210)
Common genetic determinants of vitamin D insufficiency: a genome-wide association study (2010) (1177)
Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes (2009) (1000)
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes (2010) (952)
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus (1997) (845)
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity (2020) (819)
Genome-wide association study and meta-analysis finds over 40 loci affect risk of type 1 diabetes (2009) (818)
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. (1996) (815)
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England (2021) (806)
Genomic atlas of the human plasma proteome (2018) (799)
Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus (1995) (775)
Genetic Analysis of Autoimmune Disease (1996) (766)
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC (2006) (764)
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters (2016) (747)
A molecular basis for MHC class II--associated autoimmunity. (1988) (678)
Genetic control of autoimmune diabetes in the NOD mouse. (1995) (674)
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region (2006) (660)
SARS-CoV-2 evolution during treatment of chronic infection (2021) (647)
HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk (2008) (637)
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls (2010) (600)
Shared and distinct genetic variants in type 1 diabetes and celiac disease. (2008) (571)
Population structure, differential bias and genomic control in a large-scale, case-control association study (2005) (570)
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. (1987) (563)
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A (2007) (548)
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. (2004) (537)
Pervasive Sharing of Genetic Effects in Autoimmune Disease (2011) (537)
Genetic analysis of autoimmune type 1 diabetes mellitus in mice (1991) (526)
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers (2015) (520)
Genetics of type 1 diabetes. (1997) (516)
Microsatellites for linkage analysis of genetic traits. (1992) (505)
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci (2008) (505)
Genome-wide association study of copy number variation in 16,000 cases of eight common diseases and 3,000 shared controls (2010) (465)
Detecting Disease Associations due to Linkage Disequilibrium Using Haplotype Tags: A Class of Tests and the Determinants of Statistical Power (2003) (451)
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes (2007) (449)
Bayesian refinement of association signals for 14 loci in 3 common diseases (2012) (416)
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity (2007) (395)
Widespread seasonal gene expression reveals annual differences in human immunity and physiology (2015) (378)
Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study. (1988) (376)
Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. (2005) (359)
Towards fully automated genome–wide polymorphism screening (1995) (355)
A search for type 1 diabetes susceptibility genes in families from the United Kingdom (1998) (341)
Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome (1997) (327)
Chromosome–specific microsatellite sets for fluorescence–based, semi–automated genome mapping (1994) (327)
Variation analysis and gene annotation of eight MHC haplotypes: The MHC Haplotype Project (2008) (309)
Polygenic control of autoimmune diabetes in nonobese diabetic mice (1993) (302)
Genetics of Type 1 Diabetes: What's Next? (2010) (297)
β2-Microglobulin–Deficient NOD Mice Do Not Develop Insulitis or Diabetes (1994) (295)
Human type 1 diabetes and the insulin gene: principles of mapping polygenes. (1996) (293)
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk (2010) (290)
Complete MHC haplotype sequencing for common disease gene mapping. (2004) (286)
Inherited Variation in Vitamin D Genes Is Associated With Predisposition to Autoimmune Disease Type 1 Diabetes (2011) (286)
Etiology of type 1 diabetes. (2010) (286)
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7 (2021) (285)
Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families. (2001) (284)
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource (2009) (279)
Association of the INS VNTR with size at birth (1998) (276)
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes (2009) (275)
Genetic analysis of type 1 diabetes using whole genome approaches. (1995) (274)
Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus (2009) (261)
Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. (2005) (257)
Parameters for reliable results in genetic association studies in common disease (2002) (257)
Genetic control of autoimmunity in type 1 diabetes. (1990) (256)
Overexpression of the Cytokine BAFF and Autoimmunity Risk (2017) (255)
Genome-Wide Association Analysis of Autoantibody Positivity in Type 1 Diabetes Cases (2011) (248)
Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping (1989) (247)
IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production (2009) (244)
Whole-genome sequencing of patients with rare diseases in a national health system (2020) (239)
Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models. (2001) (235)
Remapping the insulin gene/IDDM2 locus in type 1 diabetes. (2004) (229)
CD226 Gly307Ser association with multiple autoimmune diseases (2009) (227)
A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes (2014) (222)
Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom. (2004) (222)
Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33 (1995) (221)
Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases (2013) (220)
SARS-CoV-2 within-host diversity and transmission (2021) (219)
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer (2012) (213)
A newly characterized HLA DQ beta allele associated with pemphigus vulgaris. (1988) (213)
Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation. (2000) (211)
The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes (2000) (204)
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability (2013) (203)
Metagenomics and Personalized Medicine (2011) (201)
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk (2015) (199)
Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing (2009) (199)
Allelic variation in the DR subregion of the human major histocompatibility complex. (1987) (199)
The Type 1 Diabetes Genetics Consortium (2006) (197)
Association of the Vitamin D Metabolism Gene CYP27B1 With Type 1 Diabetes (2007) (195)
The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137. (2000) (194)
Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. (2004) (192)
Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele (1997) (192)
A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins. (2001) (192)
The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene. (1999) (185)
Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes (2014) (184)
Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1 (1991) (179)
NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. (2000) (176)
New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice. (1998) (176)
Panning for gold: genome-wide scanning for linkage in type 1 diabetes. (1996) (172)
Association of the interleukin‐2 receptor alpha (IL‐2Rα)/CD25 gene region with Graves’ disease using a multilocus test and tag SNPs (2007) (169)
The insulin gene VNTR, type 2 diabetes and birth weight (1999) (167)
Type 1 Diabetes-Associated IL2RA Variation Lowers IL-2 Signaling and Contributes to Diminished CD4+CD25+ Regulatory T Cell Function (2012) (167)
Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics (2020) (164)
IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus. (1996) (164)
Statistical false positive or true disease pathway? (2006) (163)
Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020 (2020) (163)
Genetic Analysis of Completely Sequenced Disease-Associated MHC Haplotypes Identifies Shuffling of Segments in Recent Human History (2006) (162)
Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. (2000) (160)
Type 1 diabetes genes and pathways shared by humans and NOD mice. (2005) (157)
Towards high resolution maps of the mouse and human genomes--a facility for ordering markers to 0.1 cM resolution. European Backcross Collaborative Group. (1994) (154)
Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes. (1995) (154)
Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus. (1989) (150)
Seven newly identified loci for autoimmune thyroid disease (2012) (147)
Mapping of the IDDM Locus Idd3 to a 0.35-cM Interval Containing the Interleukin-2 Gene (1997) (146)
Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1. (1997) (145)
Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design. (2002) (143)
From genome to aetiology in a multifactorial disease, type 1 diabetes (1999) (142)
Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes (1994) (142)
Insulin gene region–encoded susceptibility to type 1 diabetes is not restricted to HLA–DR4–positive individuals (1992) (139)
Fine Mapping, Gene Content, Comparative Sequencing, and Expression Analyses Support Ctla4 and Nramp1 as Candidates for Idd5.1 and Idd5.2 in the Nonobese Diabetic Mouse 1 (2004) (138)
Regression mapping of association between the human leukocyte antigen region and Graves disease. (2005) (137)
Major factors influencing linkage disequilibrium by analysis of different chromosome regions in distinct populations: demography, chromosome recombination frequency and selection. (2000) (137)
Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA‐B and HLA‐A (2009) (131)
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway (2022) (130)
Genetic Analysis of Adult-Onset Autoimmune Diabetes (2011) (126)
Statistical evaluation of multiple-locus linkage data in experimental species and its relevance to human studies: application to nonobese diabetic (NOD) mouse and human insulin-dependent diabetes mellitus (IDDM). (1993) (126)
Unbiased application of the transmission/disequilibrium test to multilocus haplotypes. (2000) (126)
Statistical Colocalization of Genetic Risk Variants for Related Autoimmune Diseases in the Context of Common Controls (2015) (125)
A male-female bias in type 1 diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients (1998) (125)
Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases (2015) (120)
Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes. (2002) (119)
FUT2 Nonsecretor Status Links Type 1 Diabetes Susceptibility and Resistance to Infection (2011) (116)
IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity (2003) (116)
Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease (2004) (115)
The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese. (1990) (115)
A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3 (2008) (113)
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity (2021) (112)
Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene (2011) (112)
Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice. (1993) (109)
Prevalence of Abnormal Lipid Profiles and the Relationship With the Development of Microalbuminuria in Adolescents With Type 1 Diabetes (2009) (106)
IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients (2015) (105)
Multifactorial inheritance in type 1 diabetes. (1995) (102)
Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes (2012) (101)
Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial (2016) (99)
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes (2018) (98)
Evaluation of fine mapping strategies for a multifactorial disease locus: systematic linkage and association analysis of IDDM1 in the HLA region on chromosome 6p21. (2000) (97)
Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes (2010) (97)
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci (2020) (97)
Crosses of NOD Mice With the Related NON Strain: A Polygenic Model for IDDM (1995) (96)
Insulin Gene Region-Encoded Susceptibility to IDDM Maps Upstream of the Insulin Gene (1995) (96)
Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6. (1993) (95)
Genome-Wide Scan for Linkage to Type 1 Diabetes in 2,496 Multiplex Families From the Type 1 Diabetes Genetics Consortium (2009) (94)
Genetic Control of Autoimmunity: Protection from Diabetes, but Spontaneous Autoimmune Biliary Disease in a Nonobese Diabetic Congenic Strain1 (2004) (94)
A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. (2007) (94)
Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes. (2004) (92)
Whole genome sequencing of a sporadic primary immunodeficiency cohort (2018) (92)
Human genetics: Tackling common disease (2001) (92)
Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21. (1997) (92)
Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families (2009) (91)
Interpretation of results from genetic studies of multifactorial diseases (1999) (90)
Proteome-Wide Analysis of Disease-Associated SNPs That Show Allele-Specific Transcription Factor Binding (2012) (90)
PTPN22 Trp620 Explains the Association of Chromosome 1p13 With Type 1 Diabetes and Shows a Statistical Interaction With HLA Class II Genotypes (2008) (87)
Statistical modeling of interlocus interactions in a complex disease: rejection of the multiplicative model of epistasis in type 1 diabetes. (2001) (87)
The molecular basis of the Kidd blood group polymorphism and its lack of association with type 1 diabetes susceptibility. (1997) (86)
Strategies in complex disease mapping. (2000) (85)
Clustering of autoimmune disease in parents of siblings from the Type 1 diabetes Warren repository (2004) (85)
c-fos and c-myc gene activation, ionic signals, and DNA synthesis in thymocytes. (1986) (85)
A Protective Role of the Environment in the Development of Type 1 Diabetes? (1991) (85)
Experimental aspects of copy number variant assays at CCL3L1 (2009) (85)
Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13 (2008) (85)
Additional microsatellite markers for mouse genome mapping (2004) (85)
A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease (2018) (84)
Bacillus thuringiensis var. israelensis delta-endotoxin. Cloning and expression of the toxin in sporogenic and asporogenic strains of Bacillus subtilis. (1986) (83)
Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes. (2006) (83)
A molecular basis for genetic susceptibility to insulin-dependent diabetes mellitus. (1988) (83)
Ten years of genetics and genomics: what have we achieved and where are we heading? (2010) (82)
Exponential growth, high prevalence of SARS-CoV-2, and vaccine effectiveness associated with the Delta variant (2021) (82)
Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans (2005) (81)
T1DBase: update 2011, organization and presentation of large-scale data sets for type 1 diabetes research (2010) (80)
A Method to Address Differential Bias in Genotyping in Large-Scale Association Studies (2007) (79)
Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations (2008) (79)
T1DBase: integration and presentation of complex data for type 1 diabetes research (2006) (79)
Fine-mapping, trans-ancestral, and genomic analyses identify causal variants, cells, genes, and drug targets for type 1 diabetes (2020) (79)
Differential glycosylation of interleukin 2, the molecular basis for the NOD Idd3 type 1 diabetes gene? (2000) (78)
The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases. (2000) (76)
No association of multiple type 2 diabetes loci with type 1 diabetes (2009) (76)
Childhood adiposity and risk of type 1 diabetes: A Mendelian randomization study (2017) (76)
Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects (2006) (75)
Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. IMDIAB Group. (1998) (75)
Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA-DQB1, -DQA1 and –DRB1 (2003) (75)
Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases. (2001) (75)
Conditional linkage disequilibrium analysis of a complex disease superlocus, IDDM1 in the HLA region, reveals the presence of independent modifying gene effects influencing the type 1 diabetes risk encoded by the major HLA-DQB1, -DRB1 disease loci. (2001) (75)
Transmission ratio distortion at the INS-IGF2 VNTR (1999) (74)
Conformation of alkanethiols on Au, Ag(111), and Pt(111) electrodes : a vibrational spectroscopy study (1995) (73)
CHiCP: a web-based tool for the integrative and interactive visualization of promoter capture Hi-C datasets (2016) (73)
A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene (2007) (72)
Association of Apolipoprotein ε2 Allele With Diabetic Nephropathy in Caucasian Subjects With IDDM (1998) (72)
Association of human endogenous retrovirus K-18 polymorphisms with type 1 diabetes. (2004) (70)
Gene-gene interactions in the NOD mouse model of type 1 diabetes. (2008) (70)
Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene. (2003) (70)
Chromosome contacts in activated T cells identify autoimmune disease candidate genes (2017) (70)
Reduced heat resistance of mutant spores after cloning and mutagenesis of the Bacillus subtilis gene encoding penicillin-binding protein 5 (1986) (70)
The HLA-DPB1--associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1. (2001) (69)
Scenarios for Autoimmunization of T and B Cells in Myasthenia Gravis (2003) (67)
Cloning and expression in Escherichia coli of the insecticidal δ‐endotoxin gene of Bacillus thuringiensis var. israelensis (1984) (67)
NOD Idd 5 Locus Controls Insulitis and Diabetes and Overlaps the Orthologous CTLA 4 / IDDM 12 and NRAMP 1 Loci in Humans (2000) (66)
Expression of the Type I Diabetes-associated Gene LRP5 in Macrophages, Vitamin A System Cells, and the Islets of Langerhans Suggests Multiple Potential Roles in Diabetes (2000) (66)
Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse. (2001) (65)
Extreme Clonality in Lymphoblastoid Cell Lines with Implications for Allele Specific Expression Analyses (2008) (65)
Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes (2012) (64)
Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gain. (2004) (64)
Evidence That HLA Class I and II Associations With Type 1 Diabetes, Autoantibodies to GAD and Autoantibodies to IA-2, Are Distinct (2011) (64)
Saturation multipoint linkage mapping of chromosome 6q in type 1 diabetes. (1996) (64)
The MHC haplotype project: a resource for HLA-linked association studies. (2002) (63)
Contrasting genetic association of IL2RA with SLE and ANCA – associated vasculitis (2009) (63)
Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13. (1998) (61)
Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases (2006) (61)
Molecular genetics of diabetes mellitus. (1995) (61)
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data (2019) (61)
Evidence for a type 1 diabetes susceptibility locus (IDDM10) on human chromosome 10p11-q11. (1997) (61)
Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes. (2005) (60)
Genomic reconstruction of the SARS-CoV-2 epidemic in England (2021) (59)
Beta-Cell Fragility As a Common Underlying Risk Factor in Type 1 and Type 2 Diabetes. (2017) (58)
Adaptation of the extended transmission/disequilibrium test to distinguish disease associations of multiple loci: the Conditional Extended Transmission/Disequilibrium Test (2000) (58)
T1DBase, a community web-based resource for type 1 diabetes research (2004) (58)
Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus (2021) (58)
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes (2005) (58)
No association between variation of the FOXP3 gene and common type 1 diabetes in the Sardinian population. (2004) (57)
The British Diabetic Association--Warren repository. (1990) (57)
Interactions between Idd5.1/Ctla4 and Other Type 1 Diabetes Genes1 (2007) (57)
Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes. (2000) (56)
Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity (2017) (56)
The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes (2019) (56)
Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families (2009) (56)
A Practical Approach to Identification of Susceptibility Genes for IDDM (1992) (55)
Cost-effective analysis of candidate genes using htSNPs: a staged approach (2004) (54)
Ambulatory blood pressure measurements are related to albumin excretion and are predictive for risk of microalbuminuria in young people with type 1 diabetes (2009) (54)
Genome bioinformatic analysis of nonsynonymous SNPs (2007) (53)
A Method for Gene-Based Pathway Analysis Using Genomewide Association Study Summary Statistics Reveals Nine New Type 1 Diabetes Associations (2014) (52)
Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping (2015) (52)
No association between interferon-γ receptor-1 gene polymorphism and pulmonary tuberculosis in a Gambian population sample (2004) (52)
An Allele of IKZF1 (Ikaros) Conferring Susceptibility to Childhood Acute Lymphoblastic Leukemia Protects Against Type 1 Diabetes (2011) (52)
Postthymic Expansion in Human CD4 Naive T Cells Defined by Expression of Functional High-Affinity IL-2 Receptors (2013) (52)
The IL23R A/Gln381 Allele Promotes IL-23 Unresponsiveness in Human Memory T-Helper 17 Cells and Impairs Th17 Responses in Psoriasis Patients (2013) (51)
Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes. (1998) (51)
Aod1, the immunoregulatory locus controlling abrogation of tolerance in neonatal thymectomy-induced autoimmune ovarian dysgenesis, maps to mouse chromosome 16. (1995) (51)
Analysis of the CD3 gene region and type 1 diabetes: application of fluorescence-based technology to linkage disequilibrium mapping. (1995) (51)
The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes (2007) (51)
Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6). (1998) (49)
No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes. (2005) (49)
Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls (2007) (49)
The study of CTLA‐4 and vitamin D receptor polymorphisms in the Romanian type 1 diabetes population (2002) (48)
Confirmation of novel type 1 diabetes risk loci in families (2012) (48)
Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis (2007) (47)
The molecular basis of HLA-disease association. (1989) (47)
Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes (2014) (47)
The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome. (2003) (46)
Oral insulin therapy for primary prevention of type 1 diabetes in infants with high genetic risk: the GPPAD-POInT (global platform for the prevention of autoimmune diabetes primary oral insulin trial) study protocol (2019) (46)
Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry (2011) (46)
Approaches and advances in the genetic causes of autoimmune disease and their implications (2018) (45)
Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM (1996) (45)
Lack of association of the vitamin D receptor gene with Graves’ disease in UK Caucasians (2004) (45)
Early Analysis of a potential link between viral load and the N501Y mutation in the SARS-COV-2 spike protein (2021) (45)
Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes (2003) (44)
Genetics of autoimmune disease. (1995) (43)
Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis (2019) (43)
Primary prevention of beta-cell autoimmunity and type 1 diabetes – The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) perspectives (2016) (43)
Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes. (2004) (42)
Segregation of the polypeptide translocation apparatus to regions of the endoplasmic reticulum containing ribophorins and ribosomes. I. Functional tests on rat liver microsomal subfractions (1984) (42)
Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing. (2006) (42)
Association of intercellular adhesion molecule-1 gene with type 1 diabetes (2003) (42)
Synthesis and DNA-binding properties of cationic 2,2':6',2' '-terpyridineplatinum(II) complexes containing 1,2- and 1,7-dicarba-closo-dodecaborane(12). (2002) (41)
Tests for Genetic Interactions in Type 1 Diabetes (2011) (41)
First Domain Sequence Diversity of DR and DQ Subregion Alleles (1989) (41)
Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases (2012) (41)
Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes (2011) (41)
Shared SARS-CoV-2 diversity suggests localised transmission of minority variants (2020) (41)
Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2 (2017) (40)
Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial (2014) (40)
Differential expression of penicillin-binding protein structural genes during Bacillus subtilis sporulation (1983) (39)
Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes (2015) (39)
Next Generation Sequencing Reveals the Association of DRB3*02:02 With Type 1 Diabetes (2013) (39)
INS VNTR allelic variation and dynamic insulin secretion in healthy adult non‐diabetic Caucasian subjects (1999) (38)
(2,2':6',2' '-Terpyridine)platinum(II) complexes containing (thioalkyl)dicarba-closo-dodecaborane(12) ligands. (2005) (38)
Availability of liposome content to the nervous system. Liposomes and the blood-brain barrier (1980) (38)
No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility (2006) (37)
La carte des microsatellites est arrivée! [The map of microsatellites has arrived!]. (1992) (37)
Nonobese Diabetic Congenic Strain Analysis of Autoimmune Diabetes Reveals Genetic Complexity of the Idd18 Locus and Identifies Vav3 as a Candidate Gene (2010) (37)
Investigating the utility of combining Φ29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray™ genotyping (2004) (37)
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies (2021) (37)
Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells (2019) (36)
Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. (2003) (36)
Confirmation of the DRB1-DQB1 loci as the major component of IDDM1 in the isolated founder population of Sardinia. (2000) (35)
Sequencing-Based Genotyping and Association Analysis of the MICA and MICB Genes in Type 1 Diabetes (2008) (35)
Mononucleotide repeats are an abundant source of length variants in mouse genomic DNA (2004) (35)
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil (2021) (35)
HLA class II typing of whole genome amplified mouth swab DNA. (2000) (34)
Parental Origin of Diabetes-Associated HLA Types in Sibling Pairs With Type I Diabetes (1994) (34)
An extension of the Maximum Lod Score method to X‐linked loci (1995) (33)
The usefulness of different density SNP maps for disease association studies of common variants. (2003) (33)
HLA antigens and insulin-dependent diabetes (1988) (33)
Low frequency of HLA DRB1*03 – DQB1*02 and DQB1*0302 haplotypes in Romania is consistent with the country's low incidence of Type I diabetes (2001) (33)
Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species. (2008) (33)
Heat‐shock proteins during growth and sporulation of Bacillus subtilis (1985) (33)
Common genetic determinants of vitamin D insufficiency (2011) (32)
Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse Chromosome 3 (1998) (32)
The British Diabetic Association -Warren Repository (1990) (31)
The sporulation-specific penicillin-binding protein 5a from Bacillus subtilis is a DD-carboxypeptidase in vitro. (1985) (31)
Evidence that Cd101 Is an Autoimmune Diabetes Gene in Nonobese Diabetic Mice (2011) (30)
Multiplexed immunophenotyping of human antigen-presenting cells in whole blood by polychromatic flow cytometry (2010) (30)
Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb. (2004) (30)
Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3–q14.1 (2009) (30)
Identification of Cd101 as a Susceptibility Gene for Novosphingobium aromaticivorans-Induced Liver Autoimmunity (2011) (29)
Comparison of population‐ and family‐based methods for genetic association analysis in the presence of interacting loci (2005) (29)
Preventing type 1 diabetes in childhood (2021) (29)
Allele-specific methylation of type 1 diabetes susceptibility genes. (2017) (28)
Investigation of Soluble and Transmembrane CTLA-4 Isoforms in Serum and Microvesicles (2014) (28)
The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus (2018) (28)
Heterogeneity in the magnitude of the insulin gene effect on HLA risk in type 1 diabetes. (2004) (27)
HLA class II gene associations in African American Type 1 diabetes reveal a protective HLA-DRB1*03 haplotype (2013) (27)
Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9.2. (2000) (27)
Evidence of association with type 1 diabetes in the SLC11A1 gene region (2011) (26)
Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients (2013) (26)
Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes (2005) (26)
Sex-related bias and exclusion mapping of the nonrecombinant portion of chromosome Y in human type 1 diabetes in the isolated founder population of Sardinia. (2002) (26)
Association of insulin gene VNTR polymorphism with polycystic ovary syndrome (1997) (26)
A method for identifying genetic heterogeneity within phenotypically-defined disease subgroups (2016) (26)
β‐cell specific T‐lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults (2017) (25)
Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials—GPPAD‐02 study design and first results (2019) (25)
Ethnic Differences in Human Leukocyte Antigen Markers of Susceptibility to IDDM (1994) (25)
Mapping the diabetes polygene Idd3 on mouse Chromosome 3 by use of novel congenic strains (1995) (24)
Association mapping of complex diseases in linked regions: estimation of genetic effects and feasibility of testing rare variants (2003) (24)
Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity (2016) (24)
Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing (2015) (24)
The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age (2017) (24)
Framework YAC contig anchored into a 3.2-Mb high-resolution physical map in proximal 11q13. (1997) (24)
The role of MHC class II genes in susceptibility to insulin-dependent diabetes mellitus. (1990) (23)
CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells (2020) (23)
Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression (2019) (23)
Conditional ETDT analysis of the Human Leukocyte Antigen region in type 1 diabetes (2000) (22)
Mapping of an insulin-dependent diabetes locus, Idd9, in NOD mice to Chromosome 4 (1994) (22)
A Genome-Wide Assessment of the Role of Untagged Copy Number Variants in Type 1 Diabetes (2014) (22)
Adaptation of the extended transmission/disequilibrium test to distinguish disease associations of multiple loci: the Conditional Extended Transmission/Disequilibrium Test. (2000) (22)
Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes (2014) (21)
7 Trans-racial gene mapping studies (1991) (21)
Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes (2008) (21)
T1DBase: integration and presentation of complex data for type 1 diabetes research (2007) (21)
The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes. (2018) (20)
Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease (2016) (20)
Lack of Association of the Ala45Thr Polymorphism and Other Common Variants of the NeuroD Gene With Type 1 Diabetes (2004) (20)
Consequences of natural perturbations in the human plasma proteome (2017) (20)
Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status (2011) (19)
Within-host genomics of SARS-CoV-2 (2020) (19)
Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X(7) receptor antagonist: a prospective genotyping approach. (2012) (19)
The PTPN22 Locus and Rheumatoid Arthritis: No Evidence for an Effect on Risk Independent of Arg620Trp (2010) (18)
Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial (2017) (18)
Alteration in the penicillin-binding profile of Bacillus megaterium during sporulation (1982) (18)
Evidence for a Type 1 diabetes‐specific mechanism for the insulin gene‐associated IDDM2 locus rather than a general influence on autoimmunity (2004) (18)
Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study (2015) (18)
Human IL-6RhiTIGIT− CD4+ CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile (2017) (17)
Development of an integrated genome informatics, data management and workflow infrastructure: A toolbox for the study of complex disease genetics (2004) (17)
Type 1 diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania (2004) (17)
Type 1 diabetes genome-wide association analysis with imputation identifies five new risk regions (2017) (17)
A comprehensive, statistically powered analysis of GAD2 in type 1 diabetes. (2002) (17)
Serial studies of numbers of circulating T and B lymphocytes in children with acute lymphoblastic leukaemia. (1977) (17)
Mapping multiple linked quantitative trait loci in non-obese diabetic mice using a stepwise regression strategy. (1998) (17)
Fluorescence Intensity Normalisation: Correcting for Time Effects in Large-Scale Flow Cytometric Analysis (2009) (17)
Detection and frequency estimation of rare variants in pools of genomic DNA from large populations using mutational spectrometry. (2005) (17)
Strategies for the prevention of autoimmune Type 1 diabetes (2011) (16)
Using de novo assembly to identify structural variation of eight complex immune system gene regions (2021) (16)
Lack of association of the Ala(45)Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes. (2004) (16)
No Evidence for Association of OAS1 With Type 1 Diabetes in Unaffected Siblings or Type 1 Diabetic Cases (2006) (16)
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes (2019) (15)
Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach (2022) (15)
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway (2022) (15)
Mouse Chromosome 3 (2004) (15)
An integrated platform to systematically identify causal variants and genes for polygenic human traits (2019) (14)
Assessing the effect of closed-loop insulin delivery from onset of type 1 diabetes in youth on residual beta-cell function compared to standard insulin therapy (CLOuD study): a randomised parallel study protocol (2020) (14)
A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples (2014) (14)
Association analysis of myosin IXB and type 1 diabetes. (2010) (14)
Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes (2007) (14)
NKG2D-RAE-1 Receptor-Ligand Variation Does Not Account for the NK Cell Defect in Nonobese Diabetic Mice1 (2008) (14)
D'oh! Genes and Environment Cause Crohn's Disease (2010) (13)
Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes (2006) (13)
Polymorphic residues on the I-A beta chain modulate the stimulation of T cell clones specific for the N-terminal peptide of the autoantigen myelin basic protein. (1989) (12)
Synthesis of diimineplatinum(II) complexes containing the 1,2-dicarba-closo-dodecaborane(12)-1-thiolato ligand (2003) (12)
Analysis of overlapping genetic association in type 1 and type 2 diabetes (2020) (12)
Strong association of insulin gene INS-VNTR polymorphisms with type 1 diabetes in the Romanian population. (2004) (11)
35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
Genetics of insulin-dependent diabetes; non-major histocompatibility genes. (1996) (11)
Membrane particles from Escherichia coli and Bacillus subtilis, containing penicillin-binding proteins and enriched for chromosomal-origin DNA (1985) (11)
Mapping of the diabetes polygene Idd3 on mouse Chromosome 3 using novel congenic strains (1995) (11)
Investigation of linkage of chromosome 8 to type 1 diabetes: multipoint analysis and exclusion mapping of human chromosome 8 in 593 affected sib-pair families from the U.K. and U.S. (1998) (11)
Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D) (2015) (11)
Frequent Monitoring of C-Peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home (2018) (11)
Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): a phase 2, multicentre, double-blind, randomized, placebo-controlled trial (2020) (10)
The murine type 1 diabetes loci, Idd1, Idd3, Idd5, Idd9, and Idd17/10/18, do not control thymic CD4−CD8−/TCRαβ+ deficiency in the nonobese diabetic mouse (2001) (10)
Genetic analysis of a complex, multifactorial disease, autoimmune type 1 (insulin-dependent) diabetes. (1991) (10)
Genetics of diabetes. Trans-racial gene mapping studies. (1991) (10)
Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice (2015) (10)
Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene (2003) (10)
Limitations of stratifying sib-pair data in common disease linkage studies: an example using chromosome 10p14-10q11 in type 1 diabetes. (2002) (9)
Association analysis of the lymphocyte-specific protein tyrosine kinase (LCK) gene in type 1 diabetes. (2004) (9)
Comment to: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900–905 (2005) (9)
Stem cells and a cure for type 1 diabetes? (2009) (9)
Peripheral tolerance to insulin is encoded by mimicry in the microbiome (2019) (9)
Linkage analysis of 84 microsatellite markers in intra- and interspecific backcrosses (2004) (9)
Sequencing and association analysis of the type 1 diabetes – linked region on chromosome 10p12-q11 (2007) (9)
Intolerable secretion and diabetes in tolerant transgenic mice, revisited (2016) (9)
Supplementation with Bifidobacterium longum subspecies infantis EVC001 for mitigation of type 1 diabetes autoimmunity: the GPPAD-SINT1A randomised controlled trial protocol (2021) (9)
Genetic analysis of autoimmune disease: a review (1996) (9)
The first examples of platinum(II)-amine complexes containing 1,2-dicarba-closo-dodecaborane(12) (2004) (9)
Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse. (2005) (8)
Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes (2006) (8)
Constitutive antiviral immunity at the expense of autoimmunity. (2014) (8)
Allelic variation of the type 2 tumor necrosis factor receptor gene (1994) (8)
Fine-mapping identifies causal variants for RA and T1D in DNASE1L3, SIRPG, MEG3, TNFAIP3 and CD28/CTLA4 loci (2017) (8)
Molecular Structure of Human Class II Antigens (1989) (7)
No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes. (2005) (7)
PRF1 mutation alters immune system activation, inflammation, and risk of autoimmunity (2020) (7)
Extra-binomial variation approach for analysis of pooled DNA sequencing data (2012) (7)
Increased transmission of Intercellular Adhesion Molecule-1 469E allele in type 1 Romanian diabetic families. (1999) (7)
HLA class II sequences infer mechanisms for major histocompatibility complex-associated disease susceptibility. (1989) (7)
Analysis of the Mouse CD 30 Gene A Candidate for the NOD Mouse Type 1 Diabetes Locus Idd 9 . 2 (2000) (7)
A rare IL2RA haplotype identifies SNP rs61839660 as causal for autoimmunity (2017) (7)
Evidence that UBASH3 is a causal gene for type 1 diabetes (2018) (7)
Adaptive dose-finding designs to identify multiple doses that achieve multiple response targets (2013) (6)
No Evidence of Association or Interaction between the IL 4 RA , IL 4 , and IL 13 Genes in Type 1 Diabetes (2005) (6)
In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment (2017) (6)
Genetic analysis of susceptibility to Type 1 diabetes (2004) (5)
Molecular analysis of the MHC class II region inDR4, DR7, andDR9 haplotypes (2005) (5)
Mouse microsatellites from a flow-sorted 4:6 Robertsonian chromosome (2004) (5)
Enhanced genetic analysis of type 1 diabetes by selecting variants on both effect size and significance, and by integration with autoimmune thyroid disease (2021) (5)
Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus (2021) (5)
A rapid DNA probe test for detecting human papilloma virus types 6/11 and 16 in biopsy specimens. (1989) (5)
Reply to “Insulin expression: is VNTR allele 698 really anomalous?” (1995) (5)
Identification of deleterious neutrophil states and altered granulopoiesis in sepsis (2022) (5)
Prevention of type 1 diabetes: what next? (2008) (5)
Lack of association between type 1 diabetes and the glucokinase gene (1992) (5)
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission (2022) (5)
A multimarker regression‐based test of linkage for affected sib‐pairs at two linked loci (2006) (4)
Elevations in blood glucose before and after the appearance of islet autoantibodies in children (2022) (4)
Evidence That Cd 101 Is an Autoimmune Diabetes Gene in Nonobese Diabetic Mice (2011) (4)
Panning for gold: Genomewide scanning in type 1 diabetes (1997) (4)
Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design (2002) (4)
1 – The Use of Nonradioactive DNA Probes for Rapid Diagnosis of Sexually Transmitted Bacterial Infections (1990) (3)
Mapping MHC Class II Genes and Disease-Susceptibility : Use of Polymerase Chain Reaction and Dot Hybridization for Human Leukocyte Antigen Allele Typing. (1993) (3)
Natural variation in IL-2 sensitivity influences regulatory T cell frequency and function in individuals with long-standing type 1 diabetes (2015) (3)
Identification of penicillin-binding protein 5a of Bacillus megaterium KM as a DD-carboxypeptidase. (1983) (3)
Corrigendum: Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls (2015) (3)
Circulating C-Peptide Levels in Living Children and Young People and Pancreatic β-Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration (2022) (3)
RACE-SPECIFIC DR-DQ HAPLOTYPES ALLOW FINER MAPPING OF GENETIC SUSCEPTIBILITY TO TYPE-1 (INSULIN-DEPENDENT) DIABETES (1989) (3)
Simultaneous mRNA and protein quantification at the single-cell level delineates trajectories of CD4+ T-cell differentiation (2019) (3)
Mouse chromosome 3 (2004) (3)
Validity of the Family-Based Association Test for Copy Number Variant Data in the Case of Non-Linear Intensity-Genotype Relationship (2012) (3)
Transmission-ratio distortion at Xp11.4-p21.1 in type 1 diabetes. (2000) (3)
Amylin and non-insulin-dependent (type 2) diabetes melllitus (1989) (2)
The HLA-DQB1 Gene Contributes to the Genetic Susceptibility to Insulin-Dependent Diabetes Mellitus (1989) (2)
Recent thymic emigrants produce antimicrobial IL-8, express complement receptors and are precursors of a tissue-homing Th8 lineage of memory cells (2016) (2)
Whole-genome sequencing of a sporadic primary immunodeficiency cohort (2020) (2)
The association of penicillin-binding proteins with cell elongation and septum formation in Bacillus megaterium. (1985) (2)
A method for attachment of peptides to a solid surface with enhanced immunoreactivity. (1992) (2)
Analysis of the CTLA-4 and vitamin D receptor gene polymorphisms in Romanian type 1 diabetic families. (2000) (2)
Mapping of the insulin-dependent diabetes locus Idd3 to a 0.35cM interval containing the Interleukin-2 gene (1997) (2)
Author Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications (2019) (2)
Dissection of the pathophysiology of type 1 diabetes by genetic analysis. (1993) (2)
Convincing statistical support for association of the Arg620Trp polymorphism in PTPN22 locus with Type 1 diabetes (2004) (1)
Characterization of HLA-DRβ and HLA DQβ Alleles Associated with Pemphigus Vulgaris (1989) (1)
A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples (2014) (1)
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort (2020) (1)
Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63:3835–3845 (2015) (1)
Interleukin 10 gene polymorphisms in Romanian Type 1 diabetic families (2002) (1)
Disentangling the direct and indirect effects of childhood adiposity on type 1 diabetes and immune-associated diseases: a multivariable Mendelian randomization study (2021) (1)
Trans-racial gene mapping identifies two MHC genes as susceptibility loci for insulin-dependent diabetes mellitus (1990) (1)
THE LOCALIZATION OF 2 SUSCEPTIBILITY GENES FOR INSULIN-DEPENDENT DIABETES IN THE NONOBESE DIABETIC MOUSE (1991) (1)
Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus. (2022) (1)
Analysis of N acetyl transferase gene polymorphisms in Romanian type 1 diabetic families. (2001) (1)
ANALYSIS OF INSULIN GENE REGION-ENCODED SUSCEPTIBILITY TO TYPE-1 DIABETES IN A UK DATA SET (1992) (1)
Targeting regulatory T cells with Interleukin-2 treatment in type 1 diabetes: a response-adaptive, non-randomised, open-label trial of repeat doses of Aldesleukin (DILfrequency) (2017) (1)
(2,2 ': 6 ',2 ''-Terpyridine)platinum(II) complexes (thioalkyl)dicarba-closo-dodecaborane(12) containing ligands (2005) (1)
Crystal structure of 1-(phthalimidomethyl)-1,2-dicarba-closo-dodecaborane, C11H17B10NO2 (2000) (1)
In vivo negative regulation of SARS-CoV-2 receptor, ACE2, by interferons and its genetic control (2021) (1)
Complement receptor 2 and IL-8 production identifies in adults and neonates naive T cells recently arising from the thymus (2016) (1)
The interaction of nocardicin A with the penicillin-binding proteins of Bacillus megaterium KM. (1983) (1)
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning (2022) (1)
Genetic analysis of susceptibility to EAE in mice (1994) (1)
HLA class II mediates type 1 diabetes risk by anti-insulin repertoire selection (2021) (1)
Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis (2023) (1)
High throughput sequencing data analysis workflow: mtDNA variant detection and identification of STR/Y-STR alleles and iso-alleles (2019) (1)
Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis (2020) (1)
HLA-DQÎ²57, anti-insulin T cells and insulin mimicry in autoimmune diabetes (2022) (1)
TUBERCULOSIS No association between interferon-c receptor-1 gene polymorphism and pulmonary tuberculosis in a Gambian population sample (2004) (1)
The psoriasis-protective IL23R A/Glu381 allele promotes interleukin-23 unresponsiveness in human memory T helper (Th) 17 cells and impairs Th17 response in patients with psoriasis (2012) (0)
Chromosome contacts in activated T cells identify autoimmune disease candidate genes (2017) (0)
Genotype-dependent expression of the transmembrane isoform of CTLA-4 in FOXP3(+) Tregs (2011) (0)
Individuals from multiplex insulin dependent diabetes mellitus families express higher levels of TCRBV2S1 than controls. (1997) (0)
Genetic association analysis of type 1 diabetes in > 60,000 ancestrally diverse subjects: refinement of existing association signals and discovery of novel type 1 diabetes risk loci (2019) (0)
Anti-TNF-induced IL-27 modulates regulatory T cell responses in patients with IBD that respond to therapy (2022) (0)
Segregation of the to Regions (2003) (0)
MicrovesiclesCTLA-4 Isoforms in Serum and Investigation of Soluble and Transmembrane (2014) (0)
50th European Mathematical Genetics Meeting (EMGM) 2022 (2022) (0)
F.4. Multiple Genetic Variants Associated with Autoantibody Status in Type 1 Diabetes Patients (2009) (0)
674 Examination of autoantibody profiles in a novel congenic mouse strain with biliary tract disease, the NOD.IDD3/10/17/18/9 mouse (2003) (0)
The female preponderance to autoimmune thyroid disease is reduced in multiplex type 1 diabetes families (2002) (0)
Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 3. (1993) (0)
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes (2018) (0)
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data (2019) (0)
Association analysis of HLA-DRB3, DRB4, DRB5 alleles and type 1 diabetes using next-generation sequencing with the titanium GSFLX system (type 1 diabetes consortium) (2010) (0)
Biliary Disease in a Nonobese Diabetic Autoimmune from Diabetes, but Spontaneous Genetic Control of Autoimmunity: Protection (2013) (0)
Specific type 1 diabetes risk genes underpin age-at-diagnosis and indicate joint defects in immunity, beta-cell fragility and responses to viral infections in early-onset disease (2019) (0)
Allele-speci ﬁ c methylation of type 1 diabetes susceptibility genes Journal of Autoimmunity (0)
Preventing hypoglycemia and maximising young peoples performance in sport (0)
Complement receptor 2 and IL-8 production identify in humans naïve T cells recently emigrating from the thymus and a Th8-like subset of memory T cells (2016) (0)
SARS-CoV-2 evolution during treatment of chronic infection (2021) (0)
ASSOCIATION OF N ACETYL TRANSFERASE 2 GENE POLYMORPHISMS WITH TYPE 1 DIABETES (2010) (0)
Validation of Tau Antibodies for Use in Western Blotting and Immunohistochemistry (2023) (0)
Linkage of chromosome 6 and type 1 diabetes. (1996) (0)
Successful incorporation of a genetic risk prediction research platform into routine newborn screening (2021) (0)
Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells (2023) (0)
Diabetic Mice Does Not Account for the NK Cell Defect in NKG 2 D-RAE-1 Receptor-Ligand Variation (2008) (0)
Approaches and advances in the genetic causes of autoimmune disease and their implications (2018) (0)
Genomic atlas of the human plasma proteome (2018) (0)
Tau depletion in human neurons mitigates Aβ-driven toxicity (2022) (0)
A relative risk of 107 for IDDM is conferred to non-Asp 57 homozygotes (1990) (0)
Insulin VNTR and HLA DRB1/DQB1 LOCI affect age of presentation of autoimmune diabetes in adults (1998) (0)
SEARCHING FOR SUSCEPTIBILITY GENES OF INSULIN-DEPENDENT DIABETES-MELLITUS USING MOUSE-HUMAN CHROMOSOMAL HOMOLOGIES (1993) (0)
Brief Genetics Report Lack of Association of the Ala 45 Thr Polymorphism and Other Common Variants of the NeuroD Gene With Type 1 Diabetes (2004) (0)
Evidence that UBASH3 is a causal gene for type 1 diabetes (2018) (0)
Publisher Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications (2019) (0)
Human chromosome 18q12-q21 and distal rodent chromosome 18 are associated with multiple autoimmune phenotypes. (1999) (0)
Pillars Article: Genetic Analysis of Autoimmune Type 1 Diabetes Mellitus in Mice. Nature. 1991. 351: 542-547 (2014) (0)
T1DBase: integration of public and private data in a type 1 diabetes community website (2007) (0)
Simulation work in adaptive dose-finding designs to identify dose-intervals that achieve targets in multiple endpoints (2015) (0)
Author Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications (2020) (0)
A Genome-wide Assessment of the Genetic Basis of Type 1 Diabetes (2007) (0)
Procedure hepatitis non-A non-B diagnosis. (1992) (0)
Whole-genome sequencing of patients with rare diseases in a national health system (2020) (0)
Genetic analysis of multifactorial disease: lessons from type-1 diabetes. (1991) (0)
Conditional ETDT analysis of the human leukocyte antigen region in type 1 diabetes. (2000) (0)
Edinburgh Research Explorer Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer (2018) (0)
Recent thymic emigrants produce antimicrobial IL-8 , express complement receptors and are precursors of a tissue-homing Th 8 lineage (2016) (0)
F.5. Cell-specific CD25 Expression is Determined by Type 1 Diabetes Associated IL2RA Haplotypes (2009) (0)
Strong association of the insulin gene locus (IDDM2) with Type 1 diabetes in the Romanian population (2004) (0)
Genome-wide linkage scan for type 1 diabetes: the type 1 diabetes genetics consortium (2008) (0)
A Treatise on the Line Complex. By C.M. Jessop. Pp. xv, 364. $7.95. 1969. (Chelsea.) (1972) (0)
Successful integration of newborn genetic testing into UK routine screening using prospective consent to determine eligibility for clinical trials (2022) (0)
A method to detect regions of strong differential selection between two distinct populations (2005) (0)
Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants (2021) (0)
Regulatory T Cell + CD25+ Diminished CD4 Lowers IL-2 Signaling and Contributes to Variation IL2RA Type 1 Diabetes-Associated (2012) (0)
Diabetes Gene in Nonobese Diabetic Mice Is an Autoimmune Cd101 Evidence that (0)
University of Birmingham Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR 1 and CR 2 (2017) (0)
CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells (2020) (0)
Invited Speakers (2006) (0)
Monocyte biomarkers in autoimmune type 1 diabetes (2007) (0)
No Association Between Variation of the FOXP3 Gene and Common Type 1 Diabetes in the Sardinian (2004) (0)
Using de novo assembly to identify structural variation of complex immune system gene regions (2021) (0)
Pathogenesis of type 1 (insulin‐dependent) diabetes—implications for the 1990s (1990) (0)
Here's the POInT: a multicentre European Primary Oral Insulin Trial (2019) (0)
The β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in juvenile compared to adult type 1 diabetes (2017) (0)
Regression mapping of the HLA association with Graves' disease (2005) (0)
Monocyte Immunophenotypes in Type 1Diabetes (2007) (0)
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage (2022) (0)
Defining aetiological variants within the HLA class II region that lead to the development of Graves' disease (2004) (0)
Whole-genome amplification template combined with highly multiplexed SNP typing enables large-scale association studies from archived DNA samples (2003) (0)
Identification of potential therapeutic targets in complex diseases: evidence for protection from type1 diabetes (T1D) by variants of CCR2 and CCR5 (2003) (0)
Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations (2018) (0)
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England (2022) (0)
Does Not Account for the NK Cell Defect in NKG2D-RAE-1 Receptor-Ligand Variation (2008) (0)
From genomics to aetiology in the multifactorial disease type-1 diabetes (1999) (0)
Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes (2022) (0)
Erratum: Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes (2005) (0)
SARS-CoV-2 genomics beyond the consensus sequence: evidence for circulating mixed viral populations (2020) (0)
Genetic analysis of autoimmune type 1 diabetes mellitus in mice. 1991. (2014) (0)
TheA3allele oftheHLA-DQAIlocus isassociated with susceptibility totype1diabetes inJapanese (1990) (0)
No association of TGF beta polymorphisms with T1DM genetic susceptibility in the Romanian population (2003) (0)
Low-dose IL-2 reduces IL-21+ T cells and induces a long-lived anti-inflammatory gene expression signature inversely modulated in COVID-19 patients (2022) (0)
Review Panning for gold: genome-wide scanning for linkage in type 1 (1996) (0)
High-Affinity IL-2 Receptors T Cells Defined by Expression of Functional Postthymic Expansion in Human CD4 Naive (2013) (0)
Sa.81. Do Type 1 and Type 2 Diabetes Have a Common Genetic Basis (2008) (0)
Childhood body size directly increases type 1 diabetes risk based on a lifecourse randomization approach. (2022) (0)
Publisher Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications (2019) (0)
CTLA-4 region predisposes to IDDM and Graves' disease (1996) (0)
Crystal structure of l-(phthalimidoethyl)-1,2-dicarba-closo-dodecaborane, C12H19B10NO2 (2000) (0)
T1DBase: community website for type 1 diabetes research (2005) (0)
Platinum(II) complexes containing 1,2- and 1,7-dicarba-closo-dodecaborane(12) Potential new agents for boron neutron capture therapy (2003) (0)

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