John Carbon
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American biochemist
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John Carbonbiology Degrees
Biology
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Biochemistry
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Biology
John Carbon's Degrees
- Bachelors Biochemistry University of California, Berkeley
- PhD Biochemistry Stanford University
Why Is John Carbon Influential?
(Suggest an Edit or Addition)According to Wikipedia, John A. Carbon is a professor emeritus of molecular and cellular biology at the University of California, Santa Barbara. Biography He earned his B.S. degree in chemistry in 1952 at the University of Illinois, and his Ph.D. degree in biochemistry in 1955 from Northwestern University. He did basic research developing new anticancer drugs at Abbott Laboratories for 12 years . He joined the faculty of the University of California, Santa Barbara in 1968, and became professor emeritus in 1999. His research contributions include elucidation of the mechanism of genetic missense suppression in bacteria, the development of techniques to make genomic libraries using recombinant DNA, techniques for using yeast for DNA cloning, characterization of centromere DNA, and construction of the first artificial chromosomes. Many of his later research contributions were carried out in collaboration with his wife, Professor Louise B. Clarke. He was elected to membership in the United States National Academy of Sciences and the American Academy of Arts and Sciences in 1986. Carbon was among the founding scientific advisors of the Amgen Corporation. An endowed chair in Biochemistry and Molecular Biology at UC Santa Barbara was named for Carbon. The chair is currently held by Jamey Marth.
John Carbon's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A colony bank containing synthetic CoI EI hybrid plasmids representative of the entire E. coli genome (1976) (1124)
- Isolation of a yeast centromere and construction of functional small circular chromosomes (1980) (694)
- Sequence of a yeast DNA fragment containing a chromosomal replicator and the TRP1 gene. (1980) (392)
- Nucleotide sequence comparisons and functional analysis of yeast centromere DNAs (1982) (372)
- A 240 kd multisubunit protein complex, CBF3, is a major component of the budding yeast centromere (1991) (326)
- Yeast centromere DNA is in a unique and highly ordered structure in chromosomes and small circular minichromosomes (1982) (290)
- Construction and analysis of viable deletion mutants of simian virus 40 (1976) (266)
- Point Mutations in Yeast CBF5 Can Abolish In Vivo Pseudouridylation of rRNA (1999) (238)
- High-frequency transformation of yeast by plasmids containing the cloned yeast ARG4 gene. (1979) (230)
- Functional expression of cloned yeast DNA in Escherichia coli: specific complementation of argininosuccinate lyase (argH) mutations. (1978) (230)
- Functional expression of cloned yeast DNA in Escherichia coli. (1977) (227)
- An essential yeast protein, CBF5p, binds in vitro to centromeres and microtubules (1993) (176)
- Centromeric DNA sequences in the pathogenic yeast Candida albicans are all different and unique. (2004) (173)
- Electrophoretic karyotype of Aspergillus nidulans. (1989) (169)
- Thiobases in Escherchia coli Transfer RNA: 2-Thiocytosine and 5-Methylaminomethyl-2-thiouracil (1968) (154)
- Frameshift suppression: a nucleotide addition in the anticodon of a glycine transfer RNA. (1973) (153)
- Slk19p Is a Centromere Protein That Functions to Stabilize Mitotic Spindles (1999) (149)
- Participation of Bir1p, a member of the inhibitor of apoptosis family, in yeast chromosome segregation events. (1999) (128)
- Analysis of centromeric DNA in the fission yeast Schizosaccharomyces pombe. (1986) (123)
- Isolation and characterization of a gene (CBF2) specifying a protein component of the budding yeast kinetochore (1993) (122)
- Replication in Saccharomyces cerevisiae of plasmid pBR313 carrying DNA from the yeast trpl region. (1979) (121)
- Normal and mutant glycine transfer RNAs. (1971) (114)
- Microtubule-motor activity of a yeast centromere-binding protein complex (1992) (113)
- The yeast nucleolar protein Cbf5p is involved in rRNA biosynthesis and interacts genetically with the RNA polymerase I transcription factor RRN3 (1997) (112)
- Genomic substitutions of centromeres in Saccharomyces cerevisiae (1983) (112)
- Structure of the Chromosome VII Centromere Region in Neurospora crassa: Degenerate Transposons and Simple Repeats (1998) (111)
- Biochemical construction and selection of hybrid plasmids containing specific segments of the Escherichia coli genome. (1975) (109)
- Construction of functional artificial minichromosomes in the fission yeast Schizosaccharomyces pombe. (1989) (106)
- Mutational and in vitro protein-binding studies on centromere DNA from Saccharomyces cerevisiae (1987) (106)
- Structural organization and functional analysis of centromeric DNA in the fission yeast Schizosaccharomyces pombe (1988) (105)
- Sequence variation in dispersed repetitive sequences in Saccharomyces cerevisiae. (1981) (104)
- Toxic effects of excess cloned centromeres (1986) (103)
- The nucleotide sequence of the yeast ARG4 gene. (1984) (96)
- A colony bank containing synthetic Col El hybrid plasmids representative of the entire E. coli genome. 1976. (1992) (96)
- Copy number control by a yeast centromere. (1983) (96)
- Probing the Saccharomyces cerevisiae centromeric DNA (CEN DNA)-binding factor 3 (CBF3) kinetochore complex by using atomic force microscopy. (1999) (94)
- Formation of functional centromeric chromatin is specified epigenetically in Candida albicans (2006) (93)
- KAR3-encoded kinesin is a minus-end-directed motor that functions with centromere binding proteins (CBF3) on an in vitro yeast kinetochore. (1994) (88)
- Mutational analysis of meiotic and mitotic centromere function in Saccharomyces cerevisiae. (1987) (85)
- Identification of DNA regions required for mitotic and meiotic functions within the centromere of Schizosaccharomyces pombe chromosome I (1991) (85)
- Overlap hybridization screening: isolation and characterization of overlapping DNA fragments surrounding the leu2 gene on yeast chromosome III. (1979) (84)
- Delta sequences and double symmetry in a yeast chromosomal replicator region. (1982) (82)
- Chromatin conformation of yeast centromeres (1984) (80)
- DNA methylation regulates phenotype-dependent transcriptional activity in Candida albicans (2011) (76)
- Isolation and characterization of the structural gene for secreted acid phosphatase from Schizosaccharomyces pombe. (1986) (73)
- Isolation and subcloning analysis of functional centromere DNA (CEN11) from Saccharomyces cerevisiae chromosome XI (1982) (73)
- Biochemical procedure for production of small deletions in simian virus 40 DNA. (1975) (70)
- The CENP-A homolog CaCse4p in the pathogenic yeast Candida albicans is a centromere protein essential for chromosome transmission (2002) (67)
- Centromere size and position in Candida albicans are evolutionarily conserved independent of DNA sequence heterogeneity (2007) (66)
- A reversible oxidative in activation of specific transfer RNA species. (1965) (64)
- Glycine transfer RNA of Escherichia coli. I. Structural genes for two glycine tRNA species. (1970) (62)
- Isolation and characterization of individual clones of simian virus 40 mutants containing deletions duplications and insertions in their DNA. (1975) (62)
- The Nop60B gene of Drosophila encodes an essential nucleolar protein that functions in yeast (1998) (62)
- Clustered tRNA genes in Schizosaccharomyces pombe centromeric DNA sequence repeats. (1991) (61)
- Direct selection procedure for the isolation of functional centromeric DNA. (1981) (60)
- Yeast centromeres: Structure and function (1984) (59)
- Glycine transfer RNA of Escherichia coli. II. Impaired GGA-recognition in strains containing a genetically altered transfer RNA; reversal by a secondary suppressor mutation. (1970) (59)
- Structural analysis and sequence organization of yeast centromeres. (1983) (58)
- Isolation of the centromere-linked CDC10 gene by complementation in yeast. (1980) (58)
- Cloning and characterization of centromeric DNA from Neurospora crassa (1994) (58)
- A Centromere DNA-binding Protein from Fission Yeast Affects Chromosome Segregation and Has Homology to Human CENP-B (1997) (56)
- Isolation and characterization of large transfer ribonucleic acid precursors from Escherichia coli. (1976) (50)
- Genetically and chemically derived missense suppressor transfer RNA's with altered enzymic aminoacylation rates. (1968) (48)
- Selection of specific clones from colony banks by screening with radioactive antibody. (1979) (48)
- Centromere structure and function in budding and fission yeasts. (1990) (47)
- Isolation and characterization of the yeast 3-phosphoglycerokinase gene (PGK) by an immunological screening technique. (1980) (46)
- Missense suppression due to a genetically altered tRNA. (1966) (45)
- Control of expression of a cloned yeast (Saccharomyces cerevisiae) gene (trp5) by a bacterial insertion element (IS2). (1978) (44)
- Selection of specific clones from colony banks by suppression or complementation tests. (1979) (42)
- Characterization of a yeast replication origin (ars2) and construction of stable minichromosomes containing cloned yeast centromere DNA (CEN3). (1981) (41)
- The sequence arrangement of drosophila melanogaster 5S DNA cloned in recombinant plasmids (1977) (39)
- Genetic alteration of structure and function in glycine transfer RNA of Escherichia coli: Mechanism of suppression of the tryptophan synthetase A78 mutation. (1974) (39)
- Molecular mechanism for missense suppression in E. coli (1974) (38)
- Studies of missense suppression of the tryptophan synthetase A-protein mutant A36. (1966) (38)
- The nucleotide sequence of the GGG-specific glycine transfer ribonucleic acid of Escherichia coli and of Salmonella typhimurium. (1973) (37)
- Nucleotide sequence studies of normal and genetically altered glycine transfer ribonucleic acids from Escherichia coli. (1975) (34)
- The nucleotide sequence of a precursor to the glycine- and threonine-specific transfer ribonucleic acids of Escherichia coli. (1975) (34)
- The Preparation of Several 4-Substituted Imidazo[4,5-d]pyridazines as Possible Purine Antimetabolites (1958) (33)
- Studies on the thionucleotides in transfer ribonucleic acid. Addition of N-ethylmaleimide and formation of mixed disulfides with thiol compounds. (1968) (32)
- THE EFFECTS OF NITROUS ACID ON THE ACTIVITY OF ESCHERICHIA COLI TRANSFER RIBONUCLEIC ACID. (1965) (31)
- Three adjacent transfer RNA genes in Escherichia coli. (1973) (30)
- SYNTHESIS OF α-AMINO- METHYLENECYCLOPROPANEPROPIONIC ACID (HYPOGLYCIN A) (1958) (30)
- Genetic and biochemical interactions between an essential kinetochore protein, Cbf2p/Ndc10p, and the CDC34 ubiquitin-conjugating enzyme (1995) (30)
- Direct Condensation of 2-Deoxy-D-ribose with Purines. Structure of the Products (1964) (28)
- Tightly centromere-linked gene (SPO15) essential for meiosis in the yeast Saccharomyces cerevisiae. (1986) (24)
- The amino acid recognition and ribosome combining sites of E. coli transfer RNA. (1964) (24)
- Structural studies on centromeres in the yeast Saccharomyces cerevisiae. (1986) (22)
- The nucleotide sequence of a threonine transfer ribonucleic acid from Escherichia coli. (1974) (22)
- Identification and characterization of the centromere from chromosome XIV in Saccharomyces cerevisiae. (1985) (21)
- Multifunctional Centromere Binding Factor 1 Is Essential for Chromosome Segregation in the Human Pathogenic YeastCandida glabrata (2001) (20)
- Amine oxidases. XIII. Monoamines as substrates of diamine oxidase. (1957) (20)
- Physical mapping of the transfer RNA genes on ?h80d (1973) (19)
- Pteridines. X. A New Approach to the Synthesis of Pteridines1 (1953) (19)
- A method for the deletion of restriction sites in bacterial plasmid deoxyribonucleic acid (1976) (19)
- Multiple gene loci for a single species of glycine transfer ribonucleic acid (1975) (19)
- Genetically altered tRNA-Gly subspecies in E. coli. (1969) (18)
- Studies on genetically altered transfer RNA species in Escherichia coli. (1971) (16)
- Nucleotide sequence of the 5' end of araBAD operon messenger RNA in Escherichia coli B/r. (1977) (16)
- Adjacent Nitro and Guanidino Groups. III. Preparation and Rearrangement of Some Pyrido[2,3-e]-as-triazine 1-Oxides1 (1962) (15)
- Molecular analysis of the budding yeast centromere/kinetochore. (1993) (15)
- The inhibition of polynucleotide phosphorylase by 6-mercaptopurine riboside 5'-diphosphate. (1962) (15)
- Inner Kinetochore of the Pathogenic Yeast Candida glabrata (2004) (14)
- Synthesis of Some Imidazo[4,5-d]pyridazines and Imidazo[4,5-d]triazolo[4,3-b]pyridazines (1960) (14)
- A change in the specificity of transfer RNA after partial deamination with nitrous acid. (1968) (14)
- Synthesis and Reactions of 5-Bromomethyl- and 5-Chloromethyluracil (1960) (13)
- Some New Halogen-substituted Pressor Amines of the Synephrine Type1 (1956) (12)
- Adjacent Nitro and Guanidino Groups. II. The Base-Catalyzed Rearrangement of Benzotriazine N-Oxides to Benzotriazoles1 (1962) (12)
- 1-Indolizinealanine—A Possible Tryptophan Antimetabolite (1961) (11)
- Characterization of a centromere-linked recombination hot spot in Saccharomyces cerevisiae (1987) (11)
- Saccharomyces cerevisiae mutants that tolerate centromere plasmids at high copy number. (1987) (11)
- High frequency excision of Ty elements during transformation of yeast. (1986) (11)
- A colony color assay for Saccharomyces cerevisiae mutants defective in kinetochore structure and function. (1992) (10)
- THE EXPRESSION OF YEAST DNA IN ESCHERICHIA COLI (1977) (9)
- Construction in vitro of mutants of simian virus 40: insertion of a poly(dA-dT) segment at the Hemophilus parainfluenza II restriction endonuclease cleavage site. (1975) (9)
- Restriction map of the region surrounding the EcoRI site in the pCR1 plasmid and analysis of an inserted ovalbumin gene. (1979) (9)
- Isolation of recombinant plasmids bearing cDNA to hen ovomucoid and lysozyme mRNAs. (1979) (9)
- Clustered tRNA genes in Escherichia coli: transcription and processing. (1975) (9)
- The expression of cloned eukaryotic DNA in prokaryotes. (1977) (8)
- The inhibition of anaerobic glycolysis by sodium N-lauroyl sarcosinate (1955) (8)
- SEQUENCING AND SUBCLONING ANALYSIS OF AUTONOMOUSLY REPLICATING SEQUENCES FROM YEAST CHROMOSOMAL DNA (1981) (7)
- Thiobases in escherichia coli transfer RNA: 2-thiocytosine and 5-methylaminomethyl-2-thiouracil. (1967) (7)
- Biochemical construction and selection of hybrid plasmids (6)
- Overexpression of the yeast MCK1 protein kinase suppresses conditional mutations in centromere-binding protein genes CBF2 and CBF5 (1995) (6)
- Heterocyclic Compounds Containing Adjacent Nitro and Guanidino Groups. A Novel Rearrangement of 4-Amino-5-nitro-6-guanidino-(and 6-ureido)pyrimidine (1961) (6)
- DETECTION OF E. COLI CLONES CONTAINING SPECIFIC YEAST GENES BY IMMUNOLOGICAL SCREENING (1979) (5)
- Selection procedure for isolation of centromere DNAs from Saccharomyces cerevisiae. (1983) (4)
- Identification ofDNA Regions Required forMitotic andMeiotic Functions within theCentromere ofSchizosaccharomyces pombe Chromosome I (1991) (4)
- THE ISOLATION AND CHARACTERIZATION OF SPECIFIC GENE SYSTEMS FROM THE YEAST, SACCHAROMYCES CEREVISIAE (1978) (4)
- Some New 2,6-Disubstituted-ι-dialkylaminoacetanilides (1954) (3)
- Reaction of 2-Hydroxy-3-nitro-5,6-diphenylpyrazine with Pyridine (1962) (3)
- Mutational and In Vitro Protein-Binding Studies (2003) (2)
- iunctional expression of cloned yeast DNA in Escherichia coli ( plasmid (0)
- Centromeres and Microtubules (2003) (0)
- Isolation and characterization of a gene (CBF2) specifying a protein component of the budding yeast kinetochrone (1993) (0)
- Control of expression of a cloned yeast ( Saccharomyces cerevisiae ) gene ( trp 5 ) by a bacterial insertion element ( IS 2 ) ( recombinant DNA / yeast tryptophan synthetase / plasmid ColEl / bacterial promoter ) (0)
- SYNTHETASE A-PROTEIN MUTANT A36* (2016) (0)
- Isolation of the centromere-linked CDC 1 O gene by complementation in yeast ( Saccharomyces cerevesiae / yeast transformation / yeast cloning vector / recombinant DNA ) (0)
- [13] Chemical modifications of transfer RNA (1971) (0)
- ISOLATION AND CHARACTERIZATION OF INDIVIDUAL CLONES OF SIMIAN VIRUS 40 MUTANTS CONTAINING DELETIONS, INSERTIONS AND DUPLICATIONS IN THEIR DNA (1974) (0)
- Characterization ofa Centromere-Linked Recombination HotSpot inSaccharomyces cerevisiae (1987) (0)
- Identification and characterization of the centromere from chromosome XIV in Saccharomyces cerevisiae (1985) (0)
- Recent Developments in Pteridine Synthesis (2008) (0)
- Tightly centromere-linked gene (SPO15) essential for meiosis in the yeast Saccharomyces cerevisiae (1986) (0)
- A process for the preparation of pyrido [2, 3-e] [1, 2, 4] triazine-1-oxides (1963) (0)
- Physical mapping of the transfer RNA genes on lambda-h80dglytsu+36. (1973) (0)
- Identification andCharacterization oftheCentromere from Chromosome XIVinSaccharomyces cerevisiae (1985) (0)
- The structure and function of yeast centromeres : (saccharomyces cerevisiae, yeast transformation, centromere cloning, functional minichromosomes , recombinant DNA, nucleotide sequencing ) (1981) (0)
- Clustered tRNA genes in Schizosaccharomyces pombe centromeric (2016) (0)
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