John W. Semple
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Canadian immunologist
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Why Is John W. Semple Influential?
(Suggest an Edit or Addition)According to Wikipedia, John W. Semple is a Canadian Scientist formally at St. Michael's Hospital and a Professor of Pharmacology at the University of Toronto. He is currently a Professor of Transfusion Medicine at Lund University in Sweden. He was born in Windsor, Ontario in 1959 and received his PhD in Immunology at Queen's University at Kingston, Ontario. In 1991, Semple, along with John Freedman, discovered a T helper cell defect in patients with the bleeding disorder called immune thrombocytopenia . ITP is a condition of having a low platelet count and most causes appear to be related to antibodies and T cells against platelets. Very low platelet counts can lead to a bleeding diathesis and purpura. The T cell defect was initially shown to be an exaggerated interleukin-2 response when T cells were cultured with platelets in vitro. Subsequently, this cytokine abnormality was shown by others to be responsible for many of the autoimmune mechanisms causing the disorder.
John W. Semple's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Platelets and the immune continuum (2011) (1376)
- Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo. (2006) (476)
- Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. (2014) (447)
- Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity. (1996) (332)
- Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP) (2017) (307)
- Thrombocytopenia following Pfizer and Moderna SARS‐CoV‐2 vaccination (2021) (305)
- Platelets and innate immunity (2010) (302)
- Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. (1991) (186)
- T granules in human platelets function in TLR9 organization and signaling (2012) (173)
- A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy. (2010) (173)
- Pathogenesis of immune thrombocytopenia. (2014) (168)
- Cellular immune dysfunction in immune thrombocytopenia (ITP) (2013) (161)
- Nouvelle Cuisine: Platelets Served with Inflammation (2015) (159)
- HLA alloimmunization against platelet transfusions: pathophysiology, significance, prevention and management. (2012) (143)
- Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets. (2007) (143)
- Transfusion-associated circulatory overload and transfusion-related acute lung injury. (2019) (129)
- IVIg inhibits reticuloendothelial system function and ameliorates murine passive‐immune thrombocytopenia independent of anti‐idiotype reactivity (2001) (109)
- Immune pathophysiology of autoimmune thrombocytopenic purpura. (2002) (108)
- Cellular immune mechanisms in autoimmune thrombocytopenic purpura: An update. (2003) (107)
- Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia. (2012) (92)
- Characterization of platelet‐reactive antibodies in children with varicella‐associated acute immune thrombocytopenic purpura (ITP) (1996) (88)
- A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. (2006) (87)
- Recent progress in understanding the pathogenesis of immune thrombocytopenia (2010) (81)
- T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10. (2017) (81)
- Current problems and future directions of transfusion‐induced alloimmunization: summary of an NHLBI working group (2011) (80)
- A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? (2007) (78)
- Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets. (2017) (78)
- The immunopathogenesis of immune thrombocytopenia: T cells still take center-stage (2012) (76)
- Intravenous immunoglobulin inhibits anti‐glycoprotein IIb‐induced platelet apoptosis in a murine model of immune thrombocytopenia (2006) (72)
- Platelet and immune responses to oral cyclic dexamethasone therapy in childhood chronic immune thrombocytopenic purpura. (1997) (72)
- Autoimmune pathogenesis and autoimmune hemolytic anemia. (2005) (67)
- The Pathogenic Involvement of Neutrophils in Acute Respiratory Distress Syndrome and Transfusion-Related Acute Lung Injury (2018) (65)
- Transfusion‐related immunomodulation by platelets is dependent on their expression of MHC Class I molecules and is independent of white cells (2008) (64)
- Flow cytometric analysis of platelets from childrenwith the Wiskott‐Aldrich syndrome reveals defects in platelet development, activation and structure (1997) (59)
- Indirect allorecognition of platelets by T helper cells during platelet transfusions correlates with anti-major histocompatibility complex antibody and cytotoxic T lymphocyte formation. (1995) (59)
- The Immune Nature of Platelets Revisited (2020) (59)
- Flow cytometric evaluation of platelet activation in blood collected into EDTA vs. Diatube‐H, a sodium citrate solution supplemented with theophylline, adenosine, and dipyridamole (1995) (56)
- Intravenous Immunoglobulin Prevents Murine Antibody-Mediated Acute Lung Injury at the Level of Neutrophil Reactive Oxygen Species (ROS) Production (2012) (56)
- Peripheral blood monocyte-derived chemokine blockade prevents murine transfusion-related acute lung injury (TRALI). (2014) (55)
- Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury. (2009) (53)
- Flow cytometric parameters for characterizing platelet activation by measuring P-selectin (CD62) expression: theoretical consideration and evaluation in thrombin-treated platelet populations. (2000) (52)
- Suppressed natural killer cell activity in patients with chronic autoimmune thrombocytopenic purpura (1991) (52)
- Rapid separation of CD4+ and CD19+ lymphocyte populations from human peripheral blood by a magnetic activated cell sorter (MACS). (1993) (51)
- Extreme leukoreduction of major histocompatibility complex class II positive B cells enhances allogeneic platelet immunity. (1999) (50)
- Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP): mechanisms of action. (1998) (48)
- DJ‐1/PARK7 Impairs Bacterial Clearance in Sepsis (2017) (47)
- Targeting Transfusion-Related Acute Lung Injury: The Journey From Basic Science to Novel Therapies (2018) (47)
- C-reactive protein enhances murine antibody-mediated transfusion-related acute lung injury. (2015) (47)
- An update on the pathophysiology of immune thrombocytopenia (2020) (46)
- Anti-D initially stimulates an Fc-dependent leukocyte oxidative burst and subsequently suppresses erythrophagocytosis via interleukin-1 receptor antagonist. (2003) (46)
- CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia. (2016) (44)
- Platelets as immune-sensing cells. (2016) (43)
- Anti‐D (WinRho SD™) treatment of children with chronic autoimmune thrombocytopenic purpura stimulates transient cytokine/chemokine production (2002) (41)
- Quantification of platelet activation status by analyzing P-selectin expression. (2000) (41)
- Comparison of platelet immunity in patients with SLE and with ITP. (2000) (40)
- Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury. (2018) (39)
- Acute Lung Injury Causes Asynchronous Alveolar Ventilation That Can Be Corrected by Individual Sighs. (2016) (39)
- Plasma-derived biological medicines used to promote haemostasis (2008) (39)
- Unique processing pathways within recipient antigen-presenting cells determine IgG immunity against donor platelet MHC antigens. (2000) (38)
- IgG antiplatelet immunity is dependent on an early innate natural killer cell-derived interferon-gamma response that is regulated by CD8+ T cells. (2004) (36)
- Osteopontin Mediates Murine Transfusion-Related Acute Lung Injury Via Stimulation of Pulmonary Neutrophil Accumulation. (2018) (33)
- T cell and cytokine abnormalities in patients with autoimmune thrombocytopenic purpura. (2003) (32)
- Platelet-Surface Glycoproteins in Healthy and Preeclamptic Mothers and Their Newborn Infants (1996) (32)
- Gamma-globulins prepared from sera of multiparous women bind anti-HLA antibodies and inhibit an established in vivo human alloimmune response. (2002) (31)
- The cellular immunology associated with autoimmune thrombocytopenic purpura: an update. (1998) (31)
- Infections, antigen-presenting cells, T cells, and immune tolerance: their role in the pathogenesis of immune thrombocytopenia. (2009) (30)
- The spleen dictates platelet destruction, anti-platelet antibody production, and lymphocyte distribution patterns in a murine model of immune thrombocytopenia. (2016) (29)
- Downregulation of the anti-HLA alloimmune response by variable region-reactive (anti-idiotypic) antibodies in leukemic patients transfused with platelet concentrates. (1993) (29)
- A comprehensive study of ovine haemostasis to assess suitability to model human coagulation. (2014) (29)
- The nonhemostatic immune functions of platelets. (2016) (28)
- Immunobiology of T helper cells and antigen‐presenting cells in autoimmune thrombocytopenic purpura (ITP) (1998) (27)
- Thrombopoietin receptor agonist (TPO-RA) treatment raises platelet counts and reduces anti-platelet antibody levels in mice with immune thrombocytopenia (ITP) (2020) (27)
- Allogeneic platelet transfusions prevent murine T-cell-mediated immune thrombocytopenia. (2014) (27)
- Elevation of C-reactive protein levels in patients with transfusion-related acute lung injury (2016) (26)
- Platelet Extracellular Vesicles mediate Transfusion-related Acute Lung Injury by imbalancing the Sphingolipid Rheostat. (2020) (26)
- Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules. (2021) (26)
- Abnormal cellular immune mechanisms associated with autoimmune thrombocytopenia. (1995) (26)
- FcγRI and FcγRIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopenia (2020) (25)
- Low levels of interleukin-10 in patients with transfusion-related acute lung injury. (2017) (25)
- Microparticles as biomarkers of lung disease: enumeration in biological fluids using lipid bilayer microspheres. (2016) (24)
- Mechanisms and therapeutic prospects of thrombopoietin receptor agonists. (2019) (23)
- Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells (2007) (23)
- Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets. (2017) (22)
- Innate and adaptive immunity in immune thrombocytopenia. (2013) (22)
- Processing and presentation of insulin. II. Evidence for intracellular, plasma membrane-associated and extracellular degradation of human insulin by antigen-presenting B cells. (1989) (22)
- Recipient humoral immunity against leukoreduced allogeneic platelets is suppressed by aminoguanidine, a selective inhibitor of inducible nitric oxide synthase. (1996) (21)
- Influence of antigen processing on immune responsiveness. (1988) (20)
- Transfusion-related Acute Lung Injury in the Perioperative Patient. (2019) (20)
- Single nucleotide polymorphism (SNP) analysis demonstrates a significant association of tumour necrosis factor-alpha (TNFA) with primary immune thrombocytopenia among Caucasian adults (2011) (18)
- Cellular immune mechanisms in chronic autoimmune thrombocytopenic purpura (ATP). (1992) (18)
- Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets. (2007) (18)
- Recent advances in the mechanisms and treatment of immune thrombocytopenia (2022) (17)
- Animal models of immune thrombocytopenia (ITP) (2010) (17)
- Pathways of Processing of Insulin by Antigen‐Presenting Cells (1988) (17)
- The Role of Complement in Transfusion-Related Acute Lung Injury (2019) (17)
- A Review of Romiplostim Mechanism of Action and Clinical Applicability (2021) (16)
- Transfusion of antibody‐opsonized red blood cells results in a shift in the immune response from the red blood cell to the antibody in a murine model (2010) (16)
- Splenic lymphocyte subtypes in immune thrombocytopenia: increased presence of a subtype of B‐regulatory cells (2016) (15)
- Evaluation of platelet gel characteristics using thrombin produced by the thrombin processing device: a comparative study. (2008) (15)
- Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia (2017) (15)
- Immune responsiveness against allogeneic platelet transfusions is determined by the recipient's major histocompatibility complex class II phenotype (2004) (14)
- Treating murine inflammatory diseases with an anti-erythrocyte antibody (2019) (14)
- Recipient antigen‐processing pathways of allogeneic platelet antigens: essential mediators of immunity (2002) (14)
- Platelets as Potential Immunomodulators: Is There a Role for Platelet Toll-Like Receptors? (2007) (13)
- Induction of a secondary human anti‐HLA alloimmune response in severe combined immunodeficient mice engrafted with human lymphocytes (1997) (13)
- Inhibition of xenogeneic GVHD by PEN110 treatment of donor human PBMNCs (2004) (13)
- Antiplatelet antibody‐induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia (2018) (12)
- Sulfated beef insulin treatment elicits CD8+ T cells that may abrogate immunologic insulin resistance in type I diabetes. (1989) (12)
- The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia (anx) mutation (2017) (12)
- Clinical and immunologic effects of Staphylococcal protein A immunoadsorption therapy for inhibitor to factor VIII (1992) (12)
- Processing and presentation of insulin. III. Insulin degrading enzyme: a neutral metalloendoproteinase that is non-homologous to classical endoproteinases mediates the processing of insulin epitopes for helper T cells. (1992) (12)
- Platelets deliver small packages of genetic function. (2013) (11)
- Distinct phenotypes of platelet, monocyte, and neutrophil activation occur during the acute and convalescent phase of COVID-19 (2021) (11)
- A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP) (2018) (10)
- Intravenous immunoglobulin treatment of spleen cells from patients with immune thrombocytopenia significantly increases the percentage of myeloid‐derived suppressor cells (2018) (10)
- Quality of thrombin produced from the patient's own plasma using the TPD, a new Thrombin-processing Device. (2005) (10)
- ITP three R's: regulation, routing, rituximab. (2008) (10)
- In HPA 1a-immunized women the decrease in anti-HPA 1a antibody level during pregnancy is not associated with anti-idiotypic antibodies (2009) (10)
- Leucodepletion and immune response mechanisms (2004) (9)
- Update on the pathophysiology of transfusion-related acute lung injury (2020) (9)
- Evaluation of Platelet Responses in Transfusion-Related Acute Lung Injury (TRALI) (2020) (8)
- Platelet immunology from the inside out (2020) (8)
- Pathogenic T-Cell Responses in Patients With Autoimmune Thrombocytopenic Purpura (2003) (8)
- The contribution of recipient platelets in TRALI: has the jury reached a verdict? (2020) (8)
- Natural killer cell numbers and activity in patients with chronic autoimmune thrombocytopenic purpura [letter; comment] (1994) (7)
- Biological and structural characterization of murine TRALI antibody reveals increased Fc-mediated complement activation. (2020) (7)
- Enhanced natural killer (NK) cell activity and NK-sensitive thymic cells in murine muscular dystrophy. (1983) (7)
- Future research in ITP: an ICIS consensus (2010) (7)
- White Blood Cell Subsets in Buffy Coat-Derived Platelet Concentrates: The Effect of Pre- and Poststorage Filtration (2000) (6)
- Bregging rights in ITP. (2012) (6)
- Antigen binding and processing by B-cell antigen-presenting cells: influence on T- and B-cell activation. (1989) (6)
- Management of Immune Thrombocytopenic Purpura in Children (2011) (6)
- Altered processing of human insulin by B lymphocytes from an immunologically insulin-resistant type I diabetic patient. (1991) (6)
- The Specificity and Isotype of Monoclonal Anti-D Antibodies Dictates Their Ability To Inhibit Opsonized Platelet Phagocytosis. (2006) (6)
- Platelets play a direct role in sepsis-associated endothelial cell death (2008) (5)
- Platelets in ITP: Victims in Charge of Their Own Fate? (2021) (5)
- Natural killer cell numbers and activity in patients with chronic autoimmune thrombocytopenic purpura. (1994) (5)
- Processed platelet HPA1a peptides au naturel. (2009) (5)
- IVIG induces dose-dependent amelioration of ITP in rodent models. (2003) (5)
- Leukoreduction Just Doesn't “Take Away” Immunogenic Leukcocytes, It Creates an Immunosuppressive Leukocyte Dose. (2002) (4)
- Move over Tregs, MDSCs are here. (2016) (4)
- Natural killer (NK) cell activity in murine muscular dystrophy. II. Age-related tissue distribution and enhanced NK activity in the thymus of dystrophic mice. (1984) (4)
- Transfusion‐associated circulatory overload (TACO): Time to shed light on the pathophysiology (2018) (4)
- Rituximab disciplines T cells, spares platelets (2007) (4)
- Platelets instruct T reg cells and macrophages in the resolution of lung inflammation (2021) (4)
- C-reactive protein boosts antibody-mediated platelet destruction. (2015) (4)
- Natural killer cells in murine muscular dystrophy. IV. Characterization of Percoll fractionated splenic and thymic natural killer cells and natural killer-sensitive thymocyte targets. (1986) (4)
- Purification and characterization of radiolabelled biosynthetic human insulin from Escherichia coli. Kinetics of processing by antigen presenting cells. (1988) (4)
- Mechanisms underlying autoimmunity in hematology (2006) (4)
- ITP has elevated BAFF expression. (2009) (3)
- Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates (2021) (3)
- Platelets have a role as immune cells (2012) (3)
- The Functional Role of TLR9 in Human Platelets (2011) (3)
- The EHA Research Roadmap: Platelet Disorders (2021) (3)
- Naturally processed heterodimeric disulfide-linked insulin peptides bind to major histocompatibility class II molecules on thymic epithelial cells. (1994) (3)
- Murine Bone Marrow-Derived Megakaryocytes Are Capable of Antigen Cross-Presentation on Major Histocompatibility Class (MHC) I Molecules (2015) (3)
- A New Murine Model of Immune Thrombocytopenia: Evidence of Both Antibody- and CD8+ T Cell-Mediated Platelet Destruction. (2007) (3)
- Platelet Functions Beyond Hemostasis (2016) (2)
- Intravenous immunoglobulin products: an update on their mechanisms of action (2008) (2)
- Platelet immunobiology: platelets as prey and predator (2018) (2)
- Dissecting platelet proteomics to understand the pathophysiology of immune thrombocytopenia: studies in mouse models (2022) (2)
- Platelet antigen-induced regulation in ITP. (2009) (2)
- New Emerging Developments of Platelets in Transfusion Medicine (2020) (2)
- Platelet Functions Beyond Hemostasis (2016) (2)
- The Ultimate Murine Model of Immune Thrombocytopaenia (2019) (2)
- Interleukin (IL)-10 Is an Effective Therapeutic for Murine Transfusion Related Acute Lung Injury (TRALI) (2016) (1)
- Human and Murine Immune Thrombocytopenia (ITP) Is Associated with a Peripheral Deficiency of CD4- T Regulatory Cells (Tc-regs) (2012) (1)
- About the mechanism of action of WinRho®SDF (2007) (1)
- Pancreatic involvement in murine antibody‐mediated transfusion‐related acute lung injury? (2021) (1)
- thrombocytopenia: response to intravenous IgG therapy A novel murine model of fetal and neonatal alloimmune (2008) (1)
- The immune system as seen through the eyes of a platelet (2014) (1)
- Megakaryocytes listen for their progeny’s progeny during inflammation (2020) (1)
- Successful Treatment of Thrombocytopenia with Staphylococcal Protein A (PRTX-100) in a Murine Model of Immune Thrombocytopenia (ITP) (2015) (1)
- Thrombopoietin Can Induce Tolerogenic Responses Via the Modulation of Thymic and Splenic T Lymphocyte Populations in a Murine Model of Immune Thrombocytopenia (ITP) (2012) (1)
- Natural killer cell activity in murine muscular dystrophy. III. NK-sensitive myoblast cells and lack of NK activity in beige/dystrophic hybrid mice. (1986) (1)
- Acute Lung Injury Causes Pendelluft Between Adjacent Alveoli In Vivo (2011) (1)
- Focused themed issue on immune thrombocytopenia (ITP) (2021) (1)
- Decitabine revives Treg function in ITP. (2021) (1)
- Thymic-Derived Tolerizing Dendritic Cells Are up-Regulated upon Treatment with Intravenous Immunoglobulin or Splenectomy in a Murine Model of Immune Thrombocytopenia (2015) (1)
- A novel immunosuppressive pathway involving peroxynitrate‐mediated nitration of platelet antigens within antigen‐presenting cells (2008) (1)
- Antibody- and Cell-Mediated Immune Thrombocytopenia Are Differentially Sensitive to Intravenous Gammaglobulin Therapy (2008) (1)
- Splenic Mechanisms of Thrombocytopenia (2017) (1)
- Alleviation of gram-negative bacterial lung inflammation by targeting HECTD2. (2016) (1)
- Anti-Idiotypic Regulation of the Alloimmune Response in Patients Transfused with Platelet Concentrates (1993) (1)
- Platelets give us many messages (2003) (1)
- Influence of antigen processing on thymic T-cell selection. (1991) (1)
- Religion Within the Boundary of Pure Reason, Tr. by J.W. Semple (2015) (1)
- Nitrosylation of Platelet MHC Class I Molecules Directs Their Movement into the Immunosuppressive MHC Class I Processing Pathway within Antigen Presenting Cells. (2004) (0)
- A Role for IL-1Receptor Antagonist in the Acute Therapeutic Effects of IVIg?. (2004) (0)
- Identification of a Two-Step Mechanism Responsible for Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI) (2012) (0)
- Fcγ Receptors I and III on Splenic Macrophages Mediate GPIIb/IIIa Autoantibody-Dependent Phagocytosis of Platelets in Human Immune Thrombocytopenia (2018) (0)
- A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Commentary (2007) (0)
- phagocytosis of IgG opsonized platelets Platelet-bound lipopolysaccharide enhances Fc receptor-mediated (2013) (0)
- murine transfusion-related acute lung injury ( TRALI ) Peripheral blood monocyte-derived chemokine blockade prevents (2014) (0)
- Allogeneic Platelet MHC Class I Antigens Prevent CD61 Specific Cytotoxic T Cell (CTL)-Mediated Immune Thrombocytopenia (ITP). (2010) (0)
- Platelets and their beneficial and detrimental roles in immunity (2020) (0)
- Platelet GPIb-IX has suppressive effects on septic inflammation. (2014) (0)
- Comment on Zhu et al , page 5362 ITP has elevated BAFF expression (0)
- Thymic Retention of CD4+CD25hi+FoxP3+ T Regulatory (Treg) Cells Is Responsible for Peripheral Treg Deficiency and Platelet and Megakaryocyte Destruction in Active Immune Thrombocytopenia (ITP) (2011) (0)
- Autoimmune hematological disorders (2019) (0)
- Osteopontin Mediates Murine Transfusion-Related Acute Lung Injury through Stimulation of Pulmonary Neutrophil Accumulation (2018) (0)
- Subject Index Vol. 79, 2000 (2000) (0)
- Binge-reading on immune thrombocytopenia: Everything you ever wanted to know. (2023) (0)
- ITP: A new regulatory issue! (2007) (0)
- Peripheral blood monocyte-derived chemokine blockade prevents murine antibody-mediated transfusion-related acute lung injury (TRALI) (2014) (0)
- A Murine Model Of Hemorrhagic Shock/Resuscitation Demonstrates Transfusion Related Acute Lung Injury (TRALI) Induced By Stored Platelet Transfusions (2013) (0)
- Steroids Are Less Effective In Treating Thrombocytopenia Caused by Immune Responses Against Platelet GPIbα: A Comparative Study Using Passive and Active ITP Models. (2010) (0)
- Enrichment of Complement, Immunoglobulins, and Autoantibody Targets in the Proteome of Platelets from Patients with Systemic Lupus Erythematosus (2022) (0)
- Dermal Delayed-Type Hypersensitivity Cell-Mediated Glomerulonephritis and in Mediating Effector Responses : Studies in An IL-12-Independent Role for CD 40-CD 154 (2004) (0)
- No induces apoptosis in endothelial cells during angiogenesis on fibrin matrix (1999) (0)
- Lipopolysaccharide Binds Platelet Toll-Like Receptor 4 and Mediates the Activation of Phagocytes in the Reticuloendothelial System (RES): A Novel Mechanism of Host Immunity. (2006) (0)
- CD20 B Cell Depleting Therapy Is Associated with up-Regulation of CD8+CD25highFoxp3+ T Regulatory Cells in a Murine Model of Immune Thrombocytopenia (ITP) (2014) (0)
- Extracellular Vesicle Sphingolipids from Stored Platelets Mediate Transfusion Related Acute Lung Injury (2019) (0)
- White Blood Cell Subsets in Buffy Coat‐Derived Platelet Concentrates: The Effect of Pre‐ and Poststorage Filtration (2000) (0)
- model of immune thrombocytopenia with their peripheral deficiency and thrombocytopenia in a murine T regulatory cells is associated + FoxP3 + CD25 + (2012) (0)
- CD8+ T Cells Are Predominantly Protective In a Murine Model Of ITP and Is Required For Effective Steroid Therapy (2013) (0)
- Climate change in the high Himalaya: Implications for mountaineers and indigenous communities (2010) (0)
- Platelets inhibit erythrocyte invasion by Plasmodium falciparum at physiological platelet:erythrocyte ratios (2021) (0)
- Protecting the fetus from FNAIT. (2022) (0)
- Moving target PF4 directs HIT responses. (2018) (0)
- CD4+CD25+Foxp3+ T Regulatory Cells Protect Against Murine Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI) (2015) (0)
- Mechanisms of platelet autoimmunity: The role of macrophages (1996) (0)
- Contents Vol. 79, 2000 (2000) (0)
- Intravenous Gammaglobulin (IVIg) Therapy Prevents Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI) by Directly Inhibiting Recipient Neutrophil Activation in a Murine Model (2011) (0)
- An update on the Immunopathology of Immune thrombocytopenia (ITP) (2020) (0)
- Recipient Immune Responses Induced by Allogeneic Whole Blood or Platelet Transfusions: Implications for Immunomodulation (1997) (0)
- Ceramide Containing Microparticles from Aged Stored Platelets Recapitulate Aspects of Murine Transfusion Related Acute Lung Injury (2018) (0)
- The Role of Recipient Platelets In the Prevention of Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI) (2010) (0)
- Immune Functions of Platelets (2018) (0)
- Understanding the pathophysiology of transfusion-related acute lung injury (TRALI) (2020) (0)
- sensitive to therapy mediated responses that are differentially - T cell + antibody- and CD8 A murine model of severe immune thrombocytopenia is induced by (2013) (0)
- R’s: regulation, routing, (2008) (0)
- The cellular pathophysiology of immune thrombocytopenia (2013) (0)
- Platelet-Reactive T Cell Lines from Children with Chronic Autoimmune Thrombocytopenic Purpura (AITP) (1999) (0)
- Biological Modification of Lymphocytes in Auto- and Allo-Immune Diseases1 (2003) (0)
- Anti‐D (WinRho‐SD) is associated with more than one mechanism of action in autoimmune thrombocytopenic purpura (AITP) (2000) (0)
- New Concepts of the Pathophysiology, Treatment and Clinical Aspects of Transfusion Related Acute Lung Injury (TRALI) (2017) (0)
- Erythrocyte-Specific Antibodies As a Potential New Therapeutic Modality in Autoimmune and Inflammatory Disorders Beyond Immune Thrombocytopenia (ITP) (2017) (0)
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