Julio M. Fernandez
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Julio M. Fernandezcomputer-science Degrees
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Computer Science
Julio M. Fernandez's Degrees
- Masters Computer Science Stanford University
- Bachelors Computer Science University of California, Berkeley
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Why Is Julio M. Fernandez Influential?
(Suggest an Edit or Addition)According to Wikipedia, Julio M. Fernandez is Professor at the Department of Biological Sciences Columbia University. Fernandez studied physics in Chile, then did his PhD at the University of California, Los Angeles. He did post-doctorate work in Los Angeles and Germany. In 1987 he became professor at the Department of Physiology, University of Pennsylvania, Philadelphia. Then, he moved to Rochester, Minnesota to the Department of Physiology and Biophysics, Mayo Foundation. Since 2002 he is professor at the Department of Biological Sciences, Columbia University.
Julio M. Fernandez's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Stretching Single Talin Rod Molecules Activates Vinculin Binding (2009) (1338)
- The molecular elasticity of the extracellular matrix protein tenascin (1998) (785)
- Mechanical unfolding intermediates in titin modules (1999) (755)
- Force-Clamp Spectroscopy Monitors the Folding Trajectory of a Single Protein (2004) (502)
- Reverse engineering of the giant muscle protein titin (2002) (488)
- The mechanical stability of ubiquitin is linkage dependent (2003) (432)
- Elastically Coupled Two-Level Systems as a Model for Biopolymer Extensibility (1998) (409)
- The mechanical hierarchies of fibronectin observed with single-molecule AFM. (2002) (373)
- Polysaccharide elasticity governed by chair–boat transitions of the glucopyranose ring (1998) (357)
- The unfolding kinetics of ubiquitin captured with single-molecule force-clamp techniques. (2004) (329)
- Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques. (2006) (298)
- Stretching single molecules into novel conformations using the atomic force microscope (2000) (297)
- Linkage between ATP Consumption and Mechanical Unfolding during the Protein Processing Reactions of an AAA+ Degradation Machine (2003) (296)
- Probing the chemistry of thioredoxin catalysis with force (2007) (249)
- Contour length and refolding rate of a small protein controlled by engineered disulfide bonds. (2007) (246)
- Point mutations alter the mechanical stability of immunoglobulin modules (2000) (207)
- Single protein misfolding events captured by atomic force microscopy (1999) (193)
- PEVK domain of titin: an entropic spring with actin-binding properties. (2002) (191)
- Single-molecule paleoenzymology probes the chemistry of resurrected enzymes (2011) (174)
- Exocytotic fusion is activated by Rab3a peptides (1992) (168)
- Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequence. (2009) (165)
- S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding (2014) (165)
- Multiple conformations of PEVK proteins detected by single-molecule techniques (2001) (164)
- Protein Folding Drives Disulfide Formation (2012) (152)
- The exocytotic fusion pore and neurotransmitter release (1994) (144)
- Mechanical unfolding intermediates observed by single-molecule force spectroscopy in a fibronectin type III module. (2005) (140)
- Pre- and Postfusion Regulation of Transmitter Release (1997) (138)
- Force-clamp spectroscopy of single-protein monomers reveals the individual unfolding and folding pathways of I27 and ubiquitin. (2007) (129)
- Simultaneous atomic force microscope and fluorescence measurements of protein unfolding using a calibrated evanescent wave. (2004) (126)
- Chair-boat transitions in single polysaccharide molecules observed with force-ramp AFM (2002) (124)
- Work Done by Titin Protein Folding Assists Muscle Contraction. (2016) (124)
- Single-molecule force spectroscopy measurements of bond elongation during a bimolecular reaction. (2008) (124)
- Mechanochemistry: one bond at a time. (2009) (123)
- Single-molecule force spectroscopy reveals signatures of glassy dynamics in the energy landscape of ubiquitin (2006) (123)
- Fingerprinting polysaccharides with single-molecule atomic force microscopy (2001) (113)
- Conservation of protein structure over four billion years. (2013) (112)
- Dynamics of equilibrium folding and unfolding transitions of titin immunoglobulin domain under constant forces. (2015) (109)
- Direct observation of an ensemble of stable collapsed states in the mechanical folding of ubiquitin (2009) (109)
- Force-activated reactivity switch in a bimolecular chemical reaction. (2009) (105)
- Direct observation of disulfide isomerization in a single protein (2011) (103)
- Ligand binding modulates the mechanical stability of dihydrofolate reductase. (2005) (103)
- Isopeptide Bonds Block the Mechanical Extension of Pili in Pathogenic Streptococcus pyogenes* (2010) (103)
- Force dependency of biochemical reactions measured by single-molecule force-clamp spectroscopy (2013) (97)
- Signatures of hydrophobic collapse in extended proteins captured with force spectroscopy (2007) (94)
- Localization of the site of Ca2 + release at the level of a single sarcomere in skeletal muscle fibres (1994) (93)
- Nanomechanics of HaloTag tethers. (2013) (89)
- Single homopolypeptide chains collapse into mechanically rigid conformations (2009) (89)
- Mechanical Unfolding Pathways of the Enhanced Yellow Fluorescent Protein Revealed by Single Molecule Force Spectroscopy* (2006) (87)
- Mechanical design of the first proximal Ig domain of human cardiac titin revealed by single molecule force spectroscopy. (2003) (87)
- A HaloTag Anchored Ruler for Week-Long Studies of Protein Dynamics. (2016) (85)
- Stepwise unfolding of ankyrin repeats in a single protein revealed by atomic force microscopy. (2006) (82)
- Cardiac titin: molecular basis of elasticity and cellular contribution to elastic and viscous stiffness components in myocardium (2004) (81)
- Diversity of Chemical Mechanisms in Thioredoxin Catalysis Revealed by Single-Molecule Force Spectroscopy (2009) (80)
- Elasticity, structure, and relaxation of extended proteins under force (2013) (74)
- Single-molecule Force Spectroscopy Approach to Enzyme Catalysis* (2010) (68)
- Techniques for membrane permeabilization (1985) (68)
- The micro‐mechanics of single molecules studied with atomic force microscopy (1999) (65)
- Collapse dynamics of single proteins extended by force. (2010) (64)
- Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity (2018) (63)
- Comparison of the protein-unfolding pathways between mitochondrial protein import and atomic-force microscopy measurements. (2005) (63)
- Solvent molecules bridge the mechanical unfolding transition state of a protein (2008) (63)
- Mechanical characterization of protein L in the low-force regime by electromagnetic tweezers/evanescent nanometry. (2009) (61)
- Dwell-time distribution analysis of polyprotein unfolding using force-clamp spectroscopy. (2007) (60)
- The Elasticity of Individual Titin PEVK Exons Measured by Single Molecule Atomic Force Microscopy* (2005) (60)
- CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks (2016) (58)
- Probing static disorder in Arrhenius kinetics by single-molecule force spectroscopy (2010) (58)
- Rate limit of protein elastic response is tether dependent (2012) (54)
- Kinetic measurements on single-molecule disulfide bond cleavage. (2011) (52)
- The Work of Titin Protein Folding as a Major Driver in Muscle Contraction. (2018) (51)
- Osmolyte-induced separation of the mechanical folding phases of ubiquitin (2009) (50)
- RT‐PCR cloning of Rab3 isoforms expressed in peritoneal mast cells (1994) (46)
- A single-molecule perspective on the role of solvent hydrogen bonds in protein folding and chemical reactions. (2008) (45)
- Trigger factor chaperone acts as a mechanical foldase (2017) (44)
- The Mechanical Power of Titin Folding (2019) (44)
- GTPγS stimulates exocytosis in patch-clamped rat melanotrophs (1993) (44)
- Ephemeral states in protein folding under force captured with a magnetic tweezers design (2019) (43)
- Hopping around an entropic barrier created by force. (2010) (42)
- Direct Quantification of the Attempt Frequency Determining the Mechanical Unfolding of Ubiquitin Protein* (2011) (40)
- Single Molecule Force Spectroscopy of Modular Proteins in the Nervous System (2000) (40)
- The mechanical fingerprint of a parallel polyprotein dimer. (2007) (39)
- Protein folding under mechanical forces: a physiological view. (2013) (37)
- Water’s role in the force-induced unfolding of ubiquitin (2010) (36)
- Dwell time analysis of a single-molecule mechanochemical reaction. (2008) (34)
- Sub-angstrom conformational changes of a single molecule captured by AFM variance analysis. (2006) (34)
- Mechanical Deformation Accelerates Protein Ageing. (2017) (34)
- The force-driven conformations of heparin studied with single molecule force microscopy. (2003) (33)
- A single-molecule assay to directly identify solvent-accessible disulfide bonds and probe their effect on protein folding. (2008) (29)
- Direct observation of a coil-to-helix contraction triggered by vinculin binding to talin (2019) (29)
- Single-molecule Force Spectroscopy Predicts a Misfolded, Domain-swapped Conformation in human γD-Crystallin Protein* (2015) (29)
- ERRATUM: Electrical, magnetic and structural characterization of fullerene soots (1996) (29)
- Mechanical forces regulate the reactivity of a thioester bond in a bacterial adhesin (2017) (26)
- Contrasting the individual reactive pathways in protein unfolding and disulfide bond reduction observed within a single protein. (2011) (25)
- Talin folding as the tuning fork of cellular mechanotransduction (2020) (25)
- Monitoring Oxidative Folding of a Single Protein Catalyzed by the Disulfide Oxidoreductase DsbA* (2015) (24)
- Probing the Effect of Force on HIV-1 Receptor CD4 (2014) (23)
- The elastic free energy of a tandem modular protein under force. (2015) (23)
- Protein folding modulates the chemical reactivity of a Gram-positive adhesin (2020) (23)
- Conformational Plasticity of the Essential Membrane-associated Mannosyltransferase PimA from Mycobacteria* (2013) (23)
- A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues (2019) (22)
- Role of conservative mutations in protein multi-property adaptation (2010) (22)
- Molecular strategy for blocking isopeptide bond formation in nascent pilin proteins (2018) (20)
- Proteins Breaking Bad: A Free Energy Perspective. (2017) (17)
- Force-Clamp Spectroscopy Detects Residue Co-evolution in Enzyme Catalysis* (2008) (17)
- Segmentation and the Entropic Elasticity of Modular Proteins. (2018) (17)
- Altered Thiol Chemistry in Human Amyotrophic Lateral Sclerosis-linked Mutants of Superoxide Dismutase 1* (2014) (16)
- Response to Comment on "Force-Clamp Spectroscopy Monitors the Folding Trajectory of a Single Protein" (2004) (16)
- Identifying sequential substrate binding at the single-molecule level by enzyme mechanical stabilization. (2015) (16)
- Distribution and Kinetics of Membrane (1982) (15)
- Probing osmolyte participation in the unfolding transition state of a protein (2011) (15)
- Quantifying the Titin Contribution to Muscle Force Generation using a Novel Method to Specifically Cleave the Titin Springs in Situ (2018) (12)
- Spontaneous Dimerization of Titin Protein Z1Z2 Domains Induces Strong Nanomechanical Anchoring* (2012) (11)
- The fusion pore interface: a new biological frontier (1994) (11)
- Fingerprinting single molecules in vivo. (2005) (10)
- Squid Axon Membrane Low-Frequency Dielectric Properties (1981) (9)
- Tandem repeating modular proteins avoid aggregation in single molecule force spectroscopy experiments. (2007) (9)
- A novel strategy for utilizing voice coil servoactuators in tensile tests of low volume protein hydrogels. (2015) (8)
- Force-Clamp Spectroscopy of Single Proteins (2010) (7)
- Protease Power Strokes Force Proteins to Unfold (2011) (7)
- Fingerprinting DHFR in single-molecule AFM studies. (2006) (7)
- Single Molecule Spectroscopy in Chemistry, Physics and Biology: Nobel Symposium (2010) (6)
- Extended Kalman filter estimates the contour length of a protein in single molecule atomic force microscopy experiments. (2009) (5)
- Is the Activity of the Fusion Pore Scaffold Regulated by a Coincidence Detector? (1994) (5)
- Magnetic tweezers meets AFM: ultra-stable protein dynamics across the force spectrum (2021) (4)
- Neurotransmitter release through the exocytotic fusion pore (1994) (4)
- The Science of Stretching: Mechanical Anisotropy in Titin Ig Domains (2016) (3)
- Pulsed laser imaging demonstrates the mechanism of current rectification at a hydrogel interface (1995) (3)
- Identical Sequences, Different Behaviors: Protein Diversity Captured at the Single-Molecule Level (2021) (2)
- Platform AY: Emerging Single Molecule Techniques IIMechanical characterization of Protein L in the low-force regime by electromagnetic tweezers/evanescent nanometry (2009) (1)
- Disulfide bonds: the power switches of elastic proteins (2018) (1)
- Protein folding modulates the adhesion strategy of Gram positive pathogens (2019) (1)
- A Multi-Tool Mouse Model to Study the Elasticity of Native Titin (2017) (1)
- CHAPTER 36 – Structure and Regulation of the Exocytotic Fusion Pore (1994) (1)
- Halotag Tethers to Study Titin Folding at the Single Molecule Level (2014) (1)
- An Electromagnetic Tweezers for Studying Fast Protein Folding Dynamics (2018) (1)
- Ephemeral states in protein folding under force captured with a novel magnetic tweezers design (2019) (1)
- Mechanism of malat transport in isolated barley vacuoles. (1986) (1)
- The Mechanical Power of Protein Folding (2018) (1)
- Protein Aging: Loss of Folding Contraction due to Oxidation of Cryptic Side Chains (2017) (0)
- Isopeptide-Blocker Impairs the Mechanics of Recently Translated Pilin Proteins (2018) (0)
- Placeholder Mechanism of Catalyzed Oxidative Folding is Conserved Across Multiple Domains of Life (2014) (0)
- Titin folding powers muscle contraction (2019) (0)
- A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues (2020) (0)
- Protein Folding Drives Muscle Contraction (2016) (0)
- Direct Observation of Titin Immunoglobulin Domain Unfolding-Refolding in Muscle Sarcomeres (2015) (0)
- Large-Scale Modulation of Titin Elasticity by S-Glutathionylation of Cryptic Cysteines (2014) (0)
- S3B1 Protein mechanics studied with single molecule AFM techniques.(Single Molecure Dynamics and Reactions) (2002) (0)
- Direct observation of a coil-to-helix contraction triggered by vinculin binding to talin. (2020) (0)
- Mechanical Forces are a Reactivity Switch for an Adhesin Thioester Bond (2019) (0)
- Kalman Filter Estimates of the Contour Length of an Unfolding Protein in Single-Molecule Force Spectroscopy Experiments (2009) (0)
- New and Notable Fingerprinting Single Molecules In Vivo (2005) (0)
- Paleoenzymology at the Single-Molecule Level: Probing the Chemistry of Resurrected Enzymes with Force-Clamp Spectroscopy (2010) (0)
- A Lego Toolbox for Engineering Proteins for Single Molecule Force Spectroscopy (2017) (0)
- ViewFolding Under Mechanical Forces: A Physiological (2016) (0)
- Single Molecule Force Spectroscopy with Individual Proteins (1999) (0)
- Probing the E ff ect of Force on HIV ‐ 1 Receptor CD 4 (2014) (0)
- Potassum-selective ion chennels in guard-cell protoplasts of broad beans. (1985) (0)
- Direct Identification of Two Distinct Transition State Structures in Reduction of a Disulfide Bond Revealed by Single Bond Force-clamp Spectroscopy (2009) (0)
- Disulfide Bonds are Allosteric Regulator of Mechanical Stability (2014) (0)
- Chemical synthesis of polypyrrole and polyaniline on polyester fabrics (2015) (0)
- Impact of Mavacamten on Force Generation in Single Myofibrils from Rabbit Psoas and Human Cardiac Muscle (0)
- Tracking of Qdot Conjugated Titin Antibodies in Single Myofibril Stretch Experiments Reveals Ig-domain Unfolding at Physiological Sarcomere Lengths (2009) (0)
- Trigger factor chaperone acts as a mechanical foldase (2017) (0)
- Extreme Mechanical Stability In Polyglutamine Chains Identified Using Single Molecule Force-clamp Spectroscopy (2009) (0)
- Super-proteins From Fitness-threshold Selection Statistics (2009) (0)
- Force Spectroscopy of a Bacterial Adhesin with an Internal Thioester Bond (2016) (0)
- Microparticles switching device (1994) (0)
- Posttranslational Modifications as Modulators of Mechanical Protein Folding (2014) (0)
- Protein Unfolding and Chemical Reactions Under Force: Complexity Versus Simplicity (2011) (0)
- Composition based microparticles condensed phase and procedure. (1994) (0)
- Abstract 330: A HaloTag-TEV Genetic Cassette for Mechanically Probing Native Titin (2019) (0)
- The complete folding trajectory of a single protein (2004) (0)
- High Force Magnetic Tweezers Reveal That Bacterial Adhesion Pili Act as Megadalton-scale Schock Absorbers (2020) (0)
- Single Molecule Force Spectroscopy on Proteins by AFM——Nanomechanics Meets Molecular Biology (2000) (0)
- Proving the Role of Entropic Elasticity in Protein Folding (2016) (0)
- Chemical Diversity and Origin of Thioredoxin Catalysis Revealed by Force-clamp Spectroscopy (2009) (0)
- Unraveling the Mechanisms of Oxidative Folding using Single Molecule Force Spectroscopy (2011) (0)
- Molecular Mechanotransduction in Human CD4 (2012) (0)
- Viaje molecular al pasado: nuevas técnicas permiten resucitar genes y proteínas de organismos extintos (2011) (0)
- Pre- and Postfusion Regulation Review of Transmitter Release (1997) (0)
- Mechanical Tuning of a Catalytic Cystein PKA in Thioredoxin (2011) (0)
- Dwell Time And Maximum Likelihood Analysis Of Single Molecule Disulfide Bond Reduction Events While Under A Stretching Force (2009) (0)
- 2012 Gordon Research Conference, Single molecule approaches to biology, July 15-20 2012 (2012) (0)
- 3P051 Relationship between local/global structures and import rates of mitochondrial precursor proteins (2004) (0)
- A (Relatively) Simple Method to Visualize Single Molecules (2011) (0)
- Revisiting the Free Energy of Modular Proteins under Force (2015) (0)
- Surviving a Bumpy Ride in the Oropharynx: Bacterial Pili as Nano-Seatbelts that Dissipate Mechanical Energy (2014) (0)
- Direct Measurement of the Diffusion Dynamics of an Extended Poly-Ubiquitin Under Constant Force (2012) (0)
- An Intrusive Entropic Barrier Induced by Force (2011) (0)
- Retraction for Dougan et al., Probing osmolyte participation in the unfolding transition state of a protein (2011) (0)
- Solvent Bridging Determines The Molecular Architecture Of The Unfolding Transition State Of A Protein (2009) (0)
- Towards a General Platform to Study Single-Bond Chemistry Under Force (2012) (0)
- Chapter 13. Force-clamp Spectroscopy of Single Proteins (2009) (0)
- Investigating The Mechanical Stability Of Sap-1 Transcription Factor By Single Molecule Force Spectroscopy (2009) (0)
- Patch Clamp Measurements of Exocytosis (2002) (0)
- Chemistry under Force (2009) (0)
- CHAPTER 1.3:Real-time Detection of Thiol Chemistry in Single Proteins (2018) (0)
- Pulsed-laser Ca++imaging and micro-amperometry: new tools to study exocytosis in excitable cells (1995) (0)
- Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity (2018) (0)
- Revisiting Protein Folding at the Single Molecule Level (2009) (0)
- Isopeptide Bonds Block the Mechanical Extension of Pilins in Gram-Positive Bacteria (2010) (0)
- Oxidative Stress Regulates Titin Elasticity by Affecting Ig-Domain Stability (2015) (0)
- Dynamics of Thiol/Disulfide Exchange Within a Single Protein (2011) (0)
- Complex unfolding pathways and reverse mechanical hierarchy in an immunoglobulin domain of fibronectin (2004) (0)
- Dispositif de commutation a microparticules (1994) (0)
- Single Molecule Enzymology (2013) (0)
- Changes in surface-area of mast-cells during secretion depend on guanine-nucleotides. (1985) (0)
- Single Molecule Oxidative Folding (2012) (0)
- Trigger Factor Boosts the Work Done by Protein Folding under Force (2017) (0)
- Patch clamp studies on the transport of ions across the membrane of barley vacuoles. (1987) (0)
- Composition a base de microparticules en phase condensee et procede (1994) (0)
- Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy (2009) (0)
- Specific Cleavage of the Titin Springs In Situ Uncovers the Role of Titin-Based Force in Sarcomere Structure and Muscle Contraction (2019) (0)
- Mechanism of Disulfide Reduction by the Acidophilic Reductase Enzyme GILT (2010) (0)
- The Specific Cleavage of Titin Springs to Quantify the Contribution of Titin to Myocardial Passive Stiffness (2020) (0)
- Temperature Dependence of the Mechanical Unfolding of Single Ubiquitin Proteins (2011) (0)
- A Magnetic Head Design for Manipulating Single Proteins with Force (2018) (0)
- Unzipping a Membrane (2000) (0)
- Studying Chemical Reactions, One Bond at a Time, with Single Molecule AFM Techniques (2008) (0)
- The Temperature Dependency of Disulfide Bond Reduction Events Measured by Single-molecule Force Clamp Spectroscopy (2009) (0)
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