Paul L. Modrich
#4,180
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American biochemist
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Paul L. Modrichbiology Degrees
Biology
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#607
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Biochemistry
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#85
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Biology
Paul L. Modrich's Degrees
- PhD Chemistry Stanford University
Why Is Paul L. Modrich Influential?
(Suggest an Edit or Addition)According to Wikipedia, Paul Lawrence Modrich is an American biochemist, James B. Duke Professor of Biochemistry at Duke University and Investigator at the Howard Hughes Medical Institute. He is known for his research on DNA mismatch repair. Modrich received the Nobel Prize in Chemistry 2015, jointly with Aziz Sancar and Tomas Lindahl.
Paul L. Modrich's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mismatch repair in replication fidelity, genetic recombination, and cancer biology. (1996) (1554)
- Hypermutability and mismatch repair deficiency in RER+ tumor cells (1993) (1060)
- Mechanisms and biological effects of mismatch repair. (1991) (868)
- DNA mismatch repair: functions and mechanisms. (2006) (702)
- Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. (1998) (688)
- BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. (2011) (651)
- Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. (1995) (619)
- DNA mismatch correction in a defined system. (1989) (553)
- Endonucleolytic Function of MutLα in Human Mismatch Repair (2006) (525)
- An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. (1993) (449)
- Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. (1996) (430)
- Mechanisms in Eukaryotic Mismatch Repair* (2006) (430)
- Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. (1995) (429)
- Mismatch repair, genetic stability, and cancer. (1994) (426)
- DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma. (1998) (422)
- Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. (1990) (393)
- Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSα* (1998) (360)
- DNA mismatch correction. (1987) (346)
- Endonucleolytic function of MutLalpha in human mismatch repair. (2006) (345)
- MutS mediates heteroduplex loop formation by a translocation mechanism (1997) (325)
- Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair (2008) (325)
- Mismatch repair deficiency in phenotypically normal human cells (1995) (322)
- Initiation of methyl-directed mismatch repair. (1992) (315)
- Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs. (1986) (315)
- Cisplatin and Adriamycin Resistance Are Associated with MutLα and Mismatch Repair Deficiency in an Ovarian Tumor Cell Line* (1996) (314)
- Mispair specificity of methyl-directed DNA mismatch correction in vitro. (1988) (306)
- HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression (2005) (300)
- Structure of the Human MutSα DNA Lesion Recognition Complex (2007) (300)
- Isolation and characterization of the Escherichia coli mutL gene product. (1989) (279)
- Recognition sequence of the dam methylase of Escherichia coli K12 and mode of cleavage of Dpn I endonuclease. (1979) (272)
- Methyl-directed DNA mismatch correction. (1989) (271)
- Human Exonuclease I Is Required for 5′ and 3′ Mismatch Repair* (2002) (271)
- Methyl-directed repair of DNA base-pair mismatches in vitro. (1983) (270)
- A defined human system that supports bidirectional mismatch-provoked excision. (2004) (260)
- Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs. (1994) (258)
- Strand-specific Mismatch Repair in Mammalian Cells* (1997) (254)
- PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair (2010) (252)
- Mechanism of 5'-directed excision in human mismatch repair. (2003) (248)
- Effects of high levels of DNA adenine methylation on methyl-directed mismatch repair in Escherichia coli. (1983) (240)
- In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair (2001) (237)
- Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction. (1993) (217)
- DNA Polymerase δ Is Required for Human Mismatch Repair in Vitro * (1997) (214)
- Isolation and characterization of the Escherichia coli mutH gene product. (1987) (210)
- Methyl-directed mismatch repair is bidirectional. (1993) (209)
- Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems (1997) (205)
- Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs. (1989) (204)
- Nucleotide-promoted Release of hMutSα from Heteroduplex DNA Is Consistent with an ATP-dependent Translocation Mechanism* (1998) (199)
- hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage. (1999) (196)
- HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. (2005) (178)
- Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair–deficient malignant glioma xenograft (2005) (173)
- Engineering life: building a fab for biology. (2006) (173)
- MutS and MutL Activate DNA Helicase II in a Mismatch-dependent Manner* (1998) (171)
- Structure of the human MutSalpha DNA lesion recognition complex. (2007) (166)
- Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family. (1987) (163)
- Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase. (1993) (158)
- Bidirectional excision in methyl-directed mismatch repair. (1993) (158)
- Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90. (2004) (158)
- EcoRI endonuclease. Physical and catalytic properties of the homogenous enzyme. (1976) (157)
- Mismatch-, MutS-, MutL-, and Helicase II-dependent Unwinding from the Single-strand Break of an Incised Heteroduplex* (1998) (157)
- DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSα/hMutSβ ratio and reduces the efficiency of base–base mismatch repair (1997) (152)
- Saccharomyces cerevisiae MutLα Is a Mismatch Repair Endonuclease* (2007) (151)
- DNA Mismatch Repair: Functions and Mechanisms (2006) (149)
- Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family (2011) (146)
- EcoRI methylase. Physical and catalytic properties of the homogeneous enzyme. (1977) (143)
- Human Mismatch Repair (2005) (142)
- The MutL ATPase Is Required for Mismatch Repair* (2000) (142)
- Genomic mismatch scanning: a new approach to genetic linkage mapping (1993) (141)
- Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft. (1997) (141)
- Facilitated diffusion during catalysis by EcoRI endonuclease. Nonspecific interactions in EcoRI catalysis. (1985) (140)
- Involvement of outside DNA sequences in the major kinetic path by which EcoRI endonuclease locates and leaves its recognition sequence. (1982) (135)
- Structure of the endonuclease domain of MutL: unlicensed to cut. (2010) (132)
- A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair (2009) (129)
- Redundant Exonuclease Involvement in Escherichia coli Methyl-directed Mismatch Repair* (2001) (126)
- Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha. (2008) (125)
- Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction. (1988) (122)
- A Naturally Occurring hPMS2 Mutation Can Confer a Dominant Negative Mutator Phenotype (1998) (114)
- MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2 (1996) (113)
- Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase. (1973) (111)
- Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease. (2007) (109)
- Escherichia coli K-12 clones that overproduce dam methylase are hypermutable (1981) (108)
- DNA sequences of structural genes for Eco RI DNA restriction and modification enzymes. (1981) (108)
- Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correction. (1987) (103)
- DNA polymerase delta is required for human mismatch repair in vitro. (1997) (101)
- Distinct MutS DNA-binding Modes That Are Differentially Modulated by ATP Binding and Hydrolysis* (2001) (97)
- The negative charge of Glu-111 is required to activate the cleavage center of EcoRI endonuclease. (1989) (95)
- Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks (2009) (94)
- Thermodynamic parameters governing interaction of EcoRI endonuclease with specific and nonspecific DNA sequences. (1983) (92)
- Escherichia coli dam methylase. Physical and catalytic properties of the homogeneous enzyme. (1982) (92)
- Mismatch-containing oligonucleotide duplexes bound by the E. coli mutS-encoded protein. (1988) (91)
- DNA Chain Length Dependence of Formation and Dynamics of hMutSα·hMutLα·Heteroduplex Complexes* (2001) (91)
- Enzymatic joining of polynucleotides. IX. A simple and rapid assay of polynucleotide joining (ligase) activity by measurement of circle formation from linear deoxyadenylate-deoxythymidylate copolymer. (1970) (89)
- Mismatch Repair-dependent Iterative Excision at Irreparable O6-Methylguanine Lesions in Human Nuclear Extracts* (2006) (88)
- Modulation of MutS ATP hydrolysis by DNA cofactors. (2000) (87)
- The β Sliding Clamp Binds to Multiple Sites within MutL and MutS* (2006) (86)
- Structures and mechanisms of DNA restriction and modification enzymes (1979) (84)
- The DNA sequences encoding plsB and dgk loci of Escherichia coli. (1983) (81)
- Glu-111 is required for activation of the DNA cleavage center of EcoRI endonuclease. (1989) (79)
- Mismatch Repair Deficiency Does Not Mediate Clinical Resistance to Temozolomide in Malignant Glioma (2008) (76)
- Bacteriophage T7 deoxyribonucleic acid replication invitro. Bacteriophage T7 DNA polymerase: an an emzyme composed of phage- and host-specific subunits. (1975) (76)
- Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair (2007) (76)
- The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase (2004) (75)
- Bacteriophage T7 Deoxyribonucleic acid replication in vitro. A protein of Escherichia coli required for bacteriophage T7 DNA polymerase activity. (1975) (74)
- Repair of DNA base-pair mismatches in extracts of Escherichia coli. (1984) (74)
- Mechanisms of DNA-mismatch correction. (1990) (72)
- Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway* (2009) (71)
- DNA determinants important in sequence recognition by Eco RI endonuclease. (1981) (71)
- Membrane phospholipid synthesis in Escherichia coli. Cloning of a structural gene (plsB) of the sn-glycerol-3-phosphate acyl/transferase. (1980) (70)
- Assembly and Molecular Activities of the MutS Tetramer* (2003) (69)
- PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance (2010) (69)
- A structural basis for a phosphoramide mustard-induced DNA interstrand cross-link at 5'-d(GAC). (1995) (68)
- Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture). (2016) (68)
- Studies on sequence recognition by type II restriction and modification enzymes. (1982) (67)
- Deoxyribonucleic acid ligase. Isolation and physical characterization of the homogeneous enzyme from Escherichia coli. (1973) (65)
- Removal of polymerase-produced mutant sequences from PCR products. (1997) (63)
- Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation (2013) (63)
- DNA-dependent Activation of the hMutSα ATPase* (1998) (63)
- DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. (1997) (62)
- Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase. (1994) (61)
- The beta sliding clamp binds to multiple sites within MutL and MutS. (2006) (61)
- Differential and Simultaneous Adenosine Di- and Triphosphate Binding by MutS* (2003) (59)
- Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System* (2014) (59)
- Mutation detection with MutH, MutL, and MutS mismatch repair proteins. (1996) (58)
- Differential Specificities and Simultaneous Occupancy of Human MutSα Nucleotide Binding Sites* (2004) (58)
- MutL traps MutS at a DNA mismatch (2015) (57)
- Modulation of cyclophosphamide activity by O 6-alkylguanine-DNA alkyltransferase (1999) (55)
- Mismatch repair, genetic stability and tumour avoidance. (1995) (54)
- PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro. (2011) (51)
- Functions of MutLα, Replication Protein A (RPA), and HMGB1 in 5′-Directed Mismatch Repair* (2009) (50)
- Type-II Restriction and Modification Enzymes (1982) (50)
- Isolation of gram quantities of EcoRI restriction and modification enzymes from an overproducing strain. (1984) (48)
- Direct atomic force microscope imaging of EcoRI endonuclease site specifically bound to plasmid DNA molecules. (1996) (48)
- Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability. (1996) (47)
- T7-induced DNA polymerase. Requirement for thioredoxin sulfhydryl groups. (1983) (47)
- Involvement of the β Clamp in Methyl-directed Mismatch Repair in Vitro* (2009) (46)
- Membrane phospholipid synthesis in Escherichia coli. Identification of the sn-glycerol-3-phosphate acyltransferase polypeptide as the plsB gene product. (1980) (46)
- MutLα and Proliferating Cell Nuclear Antigen Share Binding Sites on MutSβ* (2010) (46)
- Positive-selection cloning vehicle useful for overproduction of hybrid proteins (1983) (45)
- Mapping individual cosmid DNAs by direct AFM imaging. (1997) (43)
- Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansion (2020) (39)
- Substrate dependence of the mechanism of EcoRI endonuclease. (1978) (39)
- High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6 (2001) (37)
- Role of the 2-amino group of deoxyguanosine in sequence recognition by EcoRI restriction and modification enzymes. (1977) (37)
- Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability (2000) (37)
- The MutSα-Proliferating Cell Nuclear Antigen Interaction in Human DNA Mismatch Repair*♦ (2008) (36)
- Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR‐Chk1 pathway (2010) (36)
- The DNA helicase activities of Rad3 protein of Saccharomyces cerevisiae and helicase II of Escherichia coli are differentially inhibited by covalent and noncovalent DNA modifications. (1993) (35)
- Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repair (2017) (35)
- Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations. (2004) (33)
- hMutS a - and hMutL a -dependent phosphorylation of p53 in response to DNA methylator damage (1999) (33)
- In vitro maturation of circular bacteriophage P2 DNA. Purification of ter components and characterization of the reaction. (1985) (33)
- Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma. (2002) (33)
- DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes. (2001) (31)
- Stereochemical course of nucleotidyl transfer catalyzed by bacteriophage T7 induced DNA polymerase. (1982) (30)
- Gap formation is associated with methyl-directed mismatch correction under conditions of restricted DNA synthesis. (1989) (29)
- Methyl-directed DNA mismatch repair in Escherichia coli. (1988) (27)
- 'Interactive' recognition in EcoRI restriction enzyme-DNA complex. (1984) (26)
- Enzymatic characterization of a mutant of Escherichia coli with an altered DNA ligase. (1971) (25)
- Hydrolytic function of Exo1 in mammalian mismatch repair (2014) (24)
- Mismatch repair and genetic stability in human cells. (1993) (24)
- A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children’s oncology group (2006) (23)
- T7-induced DNA polymerase. Characterization of associated exonuclease activities and resolution into biologically active subunits. (1979) (23)
- Hydrolytically Deficient MutS E694A Is Defective in the MutL-dependent Activation of MutH and in the Mismatch-dependent Assembly of the MutS · MutL · Heteroduplex Complex* (2003) (22)
- Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors (1998) (22)
- Enzymatic joining of polynucleotides. XI. Reversal of Escherichia coli deoxyribonucleic acid ligase reaction. (1972) (22)
- Regulation of phospholipid biosynthesis in Escherichia coli. Cloning of the structural gene for the biosynthetic sn-glycerol-3-phosphate dehydrogenase. (1980) (21)
- Extent of equilibrium perturbation of the DNA helix upon enzymatic methylation of adenine residues. (1985) (20)
- Mechanism of specific site location and DNA cleavage by EcoR I endonuclease. (1987) (18)
- The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease (2018) (17)
- The 2015 Nobel Prize in Chemistry The Discovery of Essential Mechanisms that Repair DNA Damage. (2016) (17)
- Increased transversions in a novel mutator colon cancer cell line (1998) (16)
- Preliminary x-ray diffraction studies of EcoRI restriction endonuclease-DNA complex. (1981) (15)
- DNA synthesis in strains of Escherichia coli K12 with temperature-sensitive DNA ligase and DNA polymerase I. (1974) (15)
- Analysis of the excision step in human DNA mismatch repair. (2006) (14)
- [12] Purification and properties of EcoRI endonuclease (1980) (13)
- Analysis of DNA mismatch repair proteins in human medulloblastoma. (1998) (13)
- Facilitated Diffusion during Catalysis by EcoRI Endonuclease (2001) (13)
- Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR) (1999) (12)
- Partial NH2- and COOH-terminal sequence and cyanogen bromide peptide analysis of Escherichia coli sn-glycerol-3-phosphate acyltransferase. (1983) (10)
- Prediction of secondary structure for Eco RI endonuclease. (1984) (9)
- Modification of Escherichia coli DNA ligase by cleavage with trypsin. (1976) (9)
- Mismatch correction. (1986) (9)
- DHFR y MSH 3 amplification in methotrexate-resistant cells alters the hMutS a y hMutS b ratio and reduces the efficiency of base – base mismatch repair ( drug resistance y genetic instability ) (1997) (8)
- In vitro studies on the bacteriophage P2 terminase system. (1981) (8)
- Investigation of the complexes of EcoRI endonuclease with decanucleotides containing canonical and modified recognition sequences using fluorescence and optical detection of magnetic resonance spectroscopy. (1988) (7)
- Escherichia coli dam Methylase (2001) (6)
- Purification and properties of EcoRI endonuclease. (1980) (5)
- Christian Raetz: scientist and friend extraordinaire. (2013) (5)
- Partial NH2- and cooh-terminal sequence analyses of Eco RI DNA restriction and modification enzymes. (1981) (4)
- Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ. (2011) (4)
- Identifying sequence similarities between DNA molecules. (2000) (3)
- The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation* (2016) (3)
- Structures and mechanisms of Eco RI DNA restriction and modification enzymes. (1981) (3)
- A human protein with antimutator activity. (1995) (2)
- DNA end resection machineries for human DNA break repair MRN constitute two − RPA − BLM − MRN and EXO 1 − RPA − DNA 2 − BLM Material (2011) (2)
- Mapping site-specific endonuclease binding to DNA by direct imaging with AFM (1995) (1)
- Deoxyribonucleic Acid Ligase ISOLATION AND PHYSICAL CHARACTERIZATION OF THE HOMOGENEOUS ENZYME FROM COLI” (2003) (1)
- Coupling of Human DNA Excision Repair and the ATR‐mediated DNA Damage Checkpoint (2015) (1)
- Early thinking on the nature of mismatch repair (2005) (1)
- Engineering life: Building a FAB for Biology. (Cover story) (2006) (1)
- Appendix NH2- AND COOH-TERMINAL SEQUENCE ANALYSES OF ECO RI DNA RESTRICTION AND (1981) (0)
- Crystal Structures of Human Exonuclease I with DNA Provides Insight into Substrate Selectivity and Mechanism (2011) (0)
- Crystal structure of human exonuclease 1 Exo1 (D173A) in complex with DNA (complex I) (2011) (0)
- human MutSalpha (MSH2/MSH6) bound to ADP and an O6-methyl-guanine T mispair (2007) (0)
- human MutSalpha (MSH2/MSH6) bound to DNA with a single base T insert (2007) (0)
- Methyl-directed repair of DNA base-pair mismatches in vitro. 1983. (2005) (0)
- Mapping site-specific endonuclease binding to DNA by direct imaging with atomic force microscopy (AFM) (1995) (0)
- human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair (2007) (0)
- AFM Visualization of the Interaction between MutS and Heteroduplex DNA (2009) (0)
- The Kinetic Mechanism of Eco RI Endonuclease * (1999) (0)
- Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA (complex II) (2011) (0)
- human MutSalpha (MSH2/MSH6) bound to a G T mispair, with ADP bound to MSH2 only (2007) (0)
- Crystal structure of human exonuclease 1 Exo1 (WT) in complex with DNA and Mn2+ (complex III) (2011) (0)
- Study of heterospecific interactions between mismatch repair proteins HexA of Streptococcus pneumoniae and Mut5-MutL of Escherichia coli (1995) (0)
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