Peter St George-Hyslop
British physician-scientist, educated at Wellington School, Somerset, UK
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(Suggest an Edit or Addition)According to Wikipedia, Peter Henry St George-Hyslop, OC, FRS, FRSC, FRCPC, is a British and Canadian medical scientist, neurologist and molecular geneticist who is known for his research into neurodegenerative diseases. St George-Hyslop is one of the most cited authors in the field of Alzheimer's disease research. He has identified a number of key genes that are responsible for nerve cell degeneration and early-onset forms of Alzheimer's disease. These include the discovery of the presenilins , Nicastrin, and SORL1 genes. Presenilin mutations are the most common cause of familial Alzheimer's disease. St George-Hyslop also co-led the discovery of the gene for the amyloid precursor protein.
Peter St George-Hyslop's Published Works
Published Works
- Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease (1995) (4114)
- Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease (2013) (3484)
- Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene (1995) (2057)
- Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease (2000) (1383)
- Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease (2014) (1230)
- The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease (2007) (1112)
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (1073)
- Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695* (2001) (962)
- Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing (2000) (958)
- Functional variants of OCTN cation transporter genes are associated with Crohn disease (2004) (825)
- Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease' (1998) (548)
- Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response (1999) (526)
- γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in? (2002) (500)
- Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14 (1992) (472)
- Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease (2013) (418)
- Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder (1990) (413)
- The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin* (1998) (391)
- Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis (2002) (387)
- Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene (1987) (370)
- Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model (2006) (359)
- Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons (1999) (317)
- Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue (1997) (301)
- Molecular genetics of Alzheimer’s disease (2000) (287)
- Common variants at MS 4 A 4 / MS 4 A 6 E , CD 2 AP , CD 33 and EPHA 1 are associated with late-onset Alzheimer ’ s disease (2011) (274)
- The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid β-protein gene (1987) (264)
- Frontotemporal dementia and its subtypes: a genome-wide association study (2014) (262)
- Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complex (1999) (225)
- TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity (2006) (222)
- Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study (2019) (194)
- Defective membrane interactions of familial Parkinson's disease mutant A30P α-synuclein (2002) (188)
- In vivo reduction of amyloid-β by a mutant copper transporter (2003) (188)
- Disturbed Activation of Endoplasmic Reticulum Stress Transducers by Familial Alzheimer's Disease-linked Presenilin-1 Mutations* (2001) (184)
- Convergent genetic and expression data implicate immunity in Alzheimer's disease (2014) (172)
- Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study (2018) (163)
- Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions (2020) (156)
- Evidence for phosphorylation and oligomeric assembly of presenilin 1. (1997) (153)
- Identification of Alzheimer disease-associated variants in genes that regulate retromer function (2012) (152)
- Transethnic genome-wide scan identifies novel Alzheimer's disease loci (2017) (149)
- Nicastrin binds to membrane-tethered Notch (2001) (137)
- Aβ-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Aβ pathology (2002) (125)
- Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations (2000) (123)
- Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer’s disease mouse models with abundant Aβ in plasma (2006) (120)
- Presenilins Interact with Armadillo Proteins Including Neural‐Specific Plakophilin‐Related Protein and β‐Catenin (1999) (115)
- Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C. (1997) (115)
- Apolipoprotein E genotype in patients with alzheimer's disease: Implications for the risk of dementia among relatives (1995) (107)
- An α-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease (1999) (88)
- Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells (1991) (87)
- Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes (2000) (86)
- Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis (2015) (83)
- Analysis of the functional effects of a mutation in SOD1 associated with familial amyotrophic lateral sclerosis (1994) (82)
- Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. (2018) (81)
- Both the Sequence and Length of the C Terminus of PEN-2 Are Critical for Intermolecular Interactions and Function of Presenilin Complexes* (2004) (80)
- Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease (2016) (78)
- Genetic association of CR1 with Alzheimer's disease: A tentative disease mechanism (2012) (78)
- Cloning and characterization of the Drosophila presenilin homologue (1997) (74)
- Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes. (2000) (74)
- Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP) (2013) (73)
- Dissociated phenotypes in presenilin transgenic mice define functionally distinct γ-secretases (2005) (72)
- Presenilin 1 is Actively Degraded by the 26S Proteasome (1998) (71)
- Familial Alzheimer's disease: Progress and problems (1989) (70)
- Molecular genetic approaches to Alzheimer's disease (1989) (69)
- Microglial activation in brain lesions with tau deposits: Comparison of human tauopathies and tau transgenic mice TgTauP301L (2008) (66)
- Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease (2006) (66)
- Three different mutations of presenilin 1 gene in early-onset Alzheimer's disease families (1996) (63)
- The Clinical phenotype of two missense mutations in the presenilin I gene in Japanese patients (1996) (61)
- Will anti-amyloid therapies work for Alzheimer's disease? (2008) (60)
- Transmission and age-at-onset patterns in familial Alzheimer??s disease: evidence for heterogeneity (1991) (56)
- Molecular genetics of Alzheimer disease amyloid. (1991) (55)
- Absence of association between Alzheimer disease and the −491 regulatory region polymorphism of APOE (1998) (54)
- Impaired conditioned taste aversion learning in APP transgenic mice (2004) (54)
- The Glu318Gly mutation of the presenilin‐1 gene does not necessarily cause Alzheimer's disease (1998) (53)
- Fine mapping of 10q and 18q for familial Alzheimer's disease in Caribbean Hispanics (2004) (53)
- Predictive testing for Wilson's disease using tightly linked and flanking DNA markers (1991) (52)
- Genetic factors in the genesis of Alzheimer's disease. (2006) (51)
- Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies (2015) (46)
- Genetic complexity of Alzheimer's disease: successes and challenges. (2006) (46)
- Epidemiology and genetics of frontotemporal dementia: a door-to-door survey in Southern Italy (2012) (44)
- Normal brain development in PS1 hypomorphic mice with markedly reduced γ-secretase cleavage of βAPP (2002) (44)
- Age-at-Onset in Late Onset Alzheimer Disease is Modified by Multiple Genetic Loci (2014) (44)
- Alzheimer amyloid peptide aβ42 regulates gene expression of transcription and growth factors. (2015) (43)
- Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death (2020) (43)
- Response to Correspondence: Pardossi-Piquard et al., “Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP.” Neuron 46, 541–554 (2007) (43)
- Aberrant Presenilin-1 Expression Downregulates LDL Receptor-Related Protein (LRP): Is LRP Central to Alzheimer's Disease Pathogenesis? (1999) (42)
- Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer’s disease brains: double-labeling immunohistochemical study (1996) (42)
- No association between apolipoprotein E genotype and late-onset depression in Alzheimer's disease (1997) (40)
- An exploration of cognitive subgroups in Alzheimer’s disease (2009) (40)
- Family reunion – The ZIP/prion gene family (2011) (39)
- Alzheimer's disease: Antibody clears senile plaques (1999) (39)
- A novel pathogenic mutation (Leu262Phe) found in the presenilin 1 gene in early-onset Alzheimer's disease (1997) (38)
- Genetic association study of PINK1 coding polymorphisms in Parkinson's disease (2004) (37)
- Mutation analysis of patients with neurodegenerative disorders using NeuroX array (2015) (37)
- Mutation of the conserved N‐terminal cysteine (Cys92) of human presenilin 1 causes increased Aβ42 secretion in mammalian cells but impaired Notch/lin‐I2 signalling in C. elegans (2000) (36)
- A TgCRND8 Mouse Model of Alzheimer's Disease Exhibits Sexual Dimorphisms in Behavioral Indices of Cognitive Reserve. (2016) (35)
- The γ /η-Secretase-Derived APP Intracellular Domain Fragments Regulate p53 (2007) (34)
- Presenilin 1 and Presenilin 2 Have Differential Effects on the Stability and Maturation of Nicastrin in Mammalian Brain* (2003) (34)
- APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies (2018) (33)
- ApolipoproteinE and Alzheimer's Disease: a Genetic, Molecular and Neuroimaging Review (1999) (32)
- Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer's disease data set (2016) (31)
- A b peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer ' s disease (30)
- Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS (2017) (29)
- Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (26)
- p53-dependent Aph-1 and Pen-2 Anti-apoptotic Phenotype Requires the Integrity of the γ-Secretase Complex but Is Independent of Its Activity* (2007) (26)
- Gerstmann-Sträussler-Scheinker disease with the Q217R mutation mimicking frontotemporal dementia (2005) (26)
- Loss of nicastrin elicits an apoptotic phenotype in mouse embryos (2006) (26)
- The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease (2012) (26)
- Association between variants in IDE-KIF11-HHEX and plasma amyloid β levels (2012) (24)
- Amyloid-β-protein isoforms in brain of subjects with PS1-linked, βAPP-linked and sporadic Alzheimer disease (1998) (23)
- Coding Mutations in SORL 1 and Alzheimer Disease (2015) (22)
- Hypermethylation of the CpG-island near the C 9 orf 72 G 4 C 2-repeat expansion in FTLD patients (2014) (22)
- Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition (2001) (21)
- Cholinergic neuron gene expression differences captured by translational profiling in a mouse model of Alzheimer's disease (2017) (20)
- Association study of the 5-hydroxytryptamine6 receptor gene in Alzheimer's disease (2002) (20)
- Analysis of C9orf72 in patients with frontotemporal dementia and amyotrophic lateral sclerosis from Argentina (2016) (19)
- A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population (2018) (19)
- LATE-ONSET ALZHEIMER DISEASE (17)
- Role of Genetics in Tests of Genotype, Status, and Disease Progression in Early-Onset Alzheimer’s Disease (1998) (17)
- Anti-Amyloid-β-Mediated Positron Emission Tomography Imaging in Alzheimer's Disease Mouse Brains (2012) (16)
- TREM 2 shedding by cleavage at the H 157 -S 158 bond is accelerated for the Alzheimer ’ s disease-associated H 157 Y variant (2017) (15)
- ALS 5 / SPG 11 / KIAA 1840 mutations cause autosomal recessive axonal Charcot – Marie – Tooth disease (2015) (15)
- Transient abundance of presenilin 1 fragments/nicastrin complex associated with synaptogenesis during development in rat cerebellum (2006) (15)
- Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice (2014) (14)
- Unravelling the disease process (2001) (14)
- γ-Secretase-like Cleavages of Notch and βAPP Are Mutually Exclusive in Human Cells (2002) (13)
- Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies (2017) (13)
- Failure to detect missense mutations in the S182 gene in a series of late-onset Alzheimer's disease cases (1995) (13)
- Rapid Generation of Protein Condensate Phase Diagrams Using Combinatorial Droplet Microfluidics (2020) (12)
- Characterizing familial corticobasal syndrome due to Alzheimer's disease pathology and PSEN1 mutations (2017) (12)
- Genetic Evidence for a Novel Familial Alzheimer’s Disease Locus on Chromosome 14: Analysis of Candidate Genes (1994) (12)
- Association analysis between Alzheimer's disease and the Nicastrin gene polymorphisms (2002) (12)
- LRP10 in α-synucleinopathies (2018) (12)
- A novel but non-pathogenic mutation in exon 4 of the human amyloid precursor protein (APP) gene (1992) (12)
- Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease (2011) (12)
- Genetic Complexity of Early-Onset Alzheimer’s Disease (2018) (11)
- Genetic and epigenetic study of an Alzheimer's disease family with monozygotic triplets. (2019) (11)
- Presenilin-1 holoprotein is an interacting partner of sarco endoplasmic reticulum calcium-ATPase and confers resistance to endoplasmic reticulum stress (2010) (11)
- Absence of association between Alzheimer disease and the regulatory region polymorphism of the PS2 gene in an Italian population (2003) (11)
- Association studies between the plasmin genes and late-onset Alzheimer's disease (2007) (11)
- Genome-Wide Linkage Scan of a Large Family with IgA Nephropathy Localizes a Novel Susceptibility Locus to Chromosome 2 q 36 (2007) (11)
- SORL 1 mutations in early-and late-onset Alzheimer disease (10)
- Regulatory RNA goes awry in Alzheimer's disease (2008) (9)
- Gene Expression Imputation Across Multiple Tissue Types Provides Insight Into the Genetic Architecture of Frontotemporal Dementia and Its Clinical Subtypes (2021) (8)
- Partial linkage map of chromosome 13q in the region of the Wilson disease and retinoblastoma genes (1988) (8)
- Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts (2013) (8)
- Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo (2007) (8)
- Intracellular traffic and neurodegenerative disorders (2009) (8)
- Tie-lines reveal interactions driving heteromolecular condensate formation (2022) (7)
- Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into the complex genetic architecture (2020) (7)
- Massachusetts Alzheimer's Disease Research Center: Progress and challenges (2015) (7)
- Mutation of the gene for the human lysosomal serine protease cathepsin G is not the cause of aberrant APP processing in familial Alzheimer disease (1993) (7)
- Interfamilial and Intrafamilial Phenotypic Heterogeneity in Familial Alzheimer's Disease (1997) (7)
- Alzheimer's disease: Selectively tuning γ-secretase (2010) (7)
- Generation of Amyloid β Protein from a Presenilin-1 and βAPP Complex☆ (2002) (7)
- Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells (2004) (7)
- The Sortilin-Related Receptor SORL 1 is Functionally and Genetically Associated with Alzheimer ’ s Disease (6)
- Lipid Rafts Act as a Common Platform for Amyloid-β Oligomer-Induced Alzheimer's Disease Pathology. (2022) (6)
- P525L promotes the aggregation of FUS by altering its biochemical and biophysical properties (2020) (6)
- Evidence for presenilin-1 involvement in amyloid angiopathy in the Alzheimer's disease-affected brain (1998) (6)
- Molecular Genetic Evidence for Etiologic Heterogeneity of Alzheimer’s Disease (1992) (5)
- Vigilin interacts with signal peptide peptidase (2012) (5)
- SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians (2013) (5)
- Lack of association between Alzheimer's disease and the promoter region polymorphisms of the nicastrin gene (2004) (5)
- MUTATION ANALYSIS OF THE MS4A AND TREM GENE-CLUSTERS IN A CASE-CONTROL ALZHEIMER’S DISEASE DATASET (2016) (5)
- Absence of linkage between familial amyotrophic lateral sclerosis and copper chaperone for the superoxide dismutase gene locus in two Italian pedigrees (2000) (5)
- Rapid Characterisation of Protein Phase Behaviour Using Droplet Microfluidics (2020) (5)
- Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90 (2022) (4)
- Interactome analyses of mature gamma-secretase complexes reveals distinct molecular environments of presenilin paralogs and preferential binding of signal peptide peptidase to PS2 (2013) (4)
- Regulation of membrane fluidity by RNF145‐triggered degradation of the lipid hydrolase ADIPOR2 (2022) (4)
- The genetics of Alzheimer's disease. (2000) (4)
- Multiphase condensates from a kinetically arrested phase transition (2022) (4)
- Molecular Genetic Strategies in Familial Alzheimer’s Disease: Theoretical and Practical Considerations (1988) (4)
- ATP-binding cassette transporter A7 (ABCA7) effects on amyloid processing and relevance to Alzheimer's disease (2012) (4)
- Z-α1-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state (2022) (3)
- Investigating the Interaction Between Characterized Amyloid-Beta Oligomers and the Prion Protein Receptor in Live Cells (2012) (3)
- OBSERVATION T 313 M PINK 1 Mutation in an Extended Highly Consanguineous Saudi Family With Early-Onset Parkinson Disease (2006) (3)
- Molecular Genetics of the Presenilins in Alzheimer's Disease (1998) (3)
- DNA Markers in Familial Alzheimer’s Disease (1986) (3)
- Localisation of presenilin 2 in human and rodent pancreatic islet beta-cells; Met239Val presenilin 2 variant is not associated with diabetes in man. (1999) (3)
- Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis (2020) (3)
- Biomolecular condensate phase diagrams with a combinatorial microdroplet platform. (2022) (3)
- Chromatin Structure, Gene Expression, and Nuclear Aluminum in Alzheimer’s Disease (1994) (3)
- High Resolution and Multidimensional Protein Condensate Phase Diagrams with a Combinatorial Microdroplet Platform (2022) (2)
- Alzheimer's Disease (2000) (2)
- Genetics Of Dementia (2008) (2)
- Picalm but not bin1 alters the secretion of beta-amyloid peptide (2012) (2)
- Genetics and Neurobiology of Alzheimer’s Disease and Frontotemporal Dementias (2006) (2)
- 150 Expression of the Presenilin proteins PS-1 and PS-2 in tissue culture cells (1996) (2)
- Identification of ALS5/SPG11/KIAA1840 Mutations in Patients with Autosomal Recessive Form of Charcot-Marie-Tooth Disease Type 2 (S44.002) (2016) (2)
- Evidence of recessive Alzheimer's disease loci in Caribbean Hispanics: Genome-wide survey of runs of homozygosity (2013) (2)
- Lack of SOD1 gene mutations and activity alterations in two Italian families with amyotrophic lateral sclerosis (2000) (2)
- Rare coding mutations identified by targeted sequencing of Alzheimer’s disease loci detected in genome-wide association studies (2015) (2)
- Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related γ-secretase (2010) (2)
- Candidate gene study in the endosome-to-Golgi retrieval pathway reveals association of retromer genes with Alzheimer's disease (2010) (1)
- IDENTIFICATION OF PEPTIDES BINDING TO PRESENILIN 1 BY SCREENING OF RANDOM PEPTIDE DISPLAY LIBRARIES (1998) (1)
- Connections, Cognition and Alzheimer’s Disease (1997) (1)
- A novel PS1 case of variant Alzheimer’s Disease with Spastic Paraplegia: the search for a gene-modifier (2002) (1)
- Solid/liquid coexistence during aging of FUS condensates (2022) (1)
- PATHOGENIC SORL1 MUTATIONS AND PARKINSONIAN FEATURES IN ALZHEIMER'S DISEASE (2016) (1)
- The Diverse Molecular Nature of Inherited Alzheimer’s Disease (1994) (1)
- 50 Mutations in the presenilin I and II genes are rare in early-onset Alzheimer's disease in Sweden (1996) (1)
- The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease (2012) (1)
- Tie-Line Analysis Reveals Interactions Driving Heteromolecular Condensate Formation (2022) (1)
- Immune-related genetic enrichment in frontotemporal dementia (2017) (1)
- Chromosome 10 and 12 loci for late-onset Alzheimer’s Disease: genetic linkage and case-control association studies (2002) (1)
- Nicastrin significantly modifies risk for familial early-onset Alzheimer's disease in a Dutch population based sample (2002) (1)
- 215. Two homologous genes associated with early onset familial Alzheimer's disease (1996) (1)
- O3-03-01 Presenilin-dependent transcriptional control of the Aβ-degrading enzyme neprilysin by AICD (2006) (1)
- Mutation of the ALS/FTD-associated RNA-binding protein FUS alters axonal cytoskeletal organisation (2022) (1)
- O3-03-07 [11C]SB-13 PET: a valid alternative for β-amyloid imaging in vivo? (2004) (1)
- P1-304 Fine mapping of 12p for memory traits: A complementary approach to understanding the genetics of Alzheimer’s disease (2006) (1)
- Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts (2013) (1)
- Intracellular FUS protein accumulation leads to cytoskeletal, organelle and cellular homeostasis perturbations (2022) (1)
- Structural biology of presenilin 1 complexes (2014) (1)
- Evaluation of APP codon 713 in schizophrenia and Alzheimerʼs disease (1993) (1)
- Changes in cognitive characteristics of TG APP CRND8 mice at early stages of immunization with beta amyloid peptide (2000) (1)
- Vigilin interacts with signal peptide peptidase (2012) (1)
- Presenilin Proteins and the Pathogenesis of Early-Onset Familial Alzheimer’s Disease: β-Amyloid Production and Parallels to Prion Diseases (1998) (1)
- P4-265 Baculoviral expressionof the presenilin mutation lacking exon 9 increase levels of an amyloid beta — like protein in SF9insect cells (2004) (1)
- P4-076 Polymorphism in the cyclooxygenase-2 (COX-2) and presenilin 2 (PS2) gene promoters: impact on inflammatory signaling and potential contribution to the etiopathology of Alzheimer's disease (AD) (2004) (0)
- Modele d'animal transgenique presentant des troubles de neurodegenerescence (2001) (0)
- O3-02-08 Fine mapping of chromosome 10 using memory and related neuropsychological phenotypes in the Caribbean hispanics (2004) (0)
- Presenilin 1 Controls (cid:103) -Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons (1999) (0)
- A ROLE OF PTPN21 IN NEURON SURVIVAL AND DEGENERATION (2016) (0)
- Abstracts from the 7th Canadian Conference on Dementia (CCD) held in Vancouver, October 2013 (2013) (0)
- The sortilin-related receptor (SORL1) influences variation in memory in late-onset Alzheimer disease (2009) (0)
- Aβ vaccination of a genetic model of Alzheimer's disease (2003) (0)
- S2-03-04 Assembly of the gamma-secretase complex (2004) (0)
- Genome Wide Association Study in Late-onset Alzheimer'S Disease Among Caribbean Hispanics Supports Clu, Picalm, Bin1, And Cugbp2 And Identifies Novel Loci (2010) (0)
- FcγReceptor Polymorphisms, Disease Severity and Response to IVIG Treatment in Myasthenia Gravis (SC02.002) (2012) (0)
- Subject Index Vol. 27, 2009 (2009) (0)
- CODING MUTATIONS IN SORL1 IMPLICATE ALTERNATE APP PROCESSING MECHANISMS IN ALZHEIMER'S DISEASE (2014) (0)
- O1-02-01 A novel presenilin complex component which modulates gamma- but not epsilon-secretase activity (2006) (0)
- P2-057 INTERACTOME ANALYSES OF MATURE GAMMA-SECRETASE COMPLEXES REVEALS DISTINCT MOLECULAR ENVIRONMENTS OF PRESENILIN PARALOGS AND PREFERENTIAL BINDINGOFSIGNALPEPTIDEPEPTIDASETOPS2 (2013) (0)
- Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1 (2018) (0)
- P1-079 Human gamma-secretase reconstituted in yeast via co-expression of presenilin, nicastrin, APH1A and PEN2 deviates from the prototype and implies the existence of auxiliary components (2006) (0)
- P3-235: Genetic contributions to age-at-onset variation in early-onset Alzheimer's disease in Caribbean Hispanic families (2008) (0)
- Rescue of APP processing in presenilin-1 deficient neurons and fibroblasts: Role of presenilins (2000) (0)
- SEARCH FOR RECESSIVE ALZHEIMER DISEASE LOCI IN AFRICAN AMERICANS BY GENOME-WIDE STUDY OF RUNS OF HOMOZYGOSITY (2014) (0)
- MUTATIONS IN THREE GENES ARE ASSOCIATED WITH EARLY ONSET ALZHEIMER’S DISEASE (1998) (0)
- Genome wide analyses of runs of homozygosity among african americans revealed further evidence of recessive inheritance for Alzheimer’s disease (2015) (0)
- S2-01-03 Genetic studies in late-onset Alzheimer disease: loci on chromosomes 12 and 10 (2004) (0)
- P4-314 APH-1, nicastrin, presenilin and PEN-2 form multiple complexes with different biological activities (2004) (0)
- Linkage Studies in a Large Kindred with Hereditary Sensory-Motor Neuropathy: Exclusion of the Duffy Locus on Chromosome 1 (1987) (0)
- P4-190: Role of gamma-secretase in lipoprotein endocytosis (2008) (0)
- P1-196 Alterations in plasma lipid levels precede amyloid plaque deposition in a murine model of Alzheimer's disease (2004) (0)
- P2-100 Divergent effects of PS1 and PS2 upon gamma-40 and gamma-42-secretase activities of the mouse CNS (2004) (0)
- P1-149 A Canadian study on the genetics of late-onset Alzheimer's disease associations: ‘Genada’ (2004) (0)
- ANALYSIS OF A FAMILY WITH IDENTICAL TRIPLETS DISCORDANT FOR ALZHEIMER’S DISEASE (2018) (0)
- The sortilin-related receptor (SORL1) influences variation in memory in late-onset Alzheimer's disease (2009) (0)
- GENETICS OF SORL1 AND ITS ROLE AS AN APP NEURONAL SORTING RECEPTOR (2018) (0)
- P3-138 Early detection of mild cognitive impairment in the community (2004) (0)
- Subject Index Vol. 18, 2004 (2004) (0)
- 782 Estimation of the mutation frequency of presenilin-1 in a population-based sample of early-onset Alzheimer disease (1996) (0)
- P3-213 Regulation of apoptotic cell death by two members of the presenilin-dependent G-secretase complex : APH-1 and PEN-2 (2006) (0)
- P4-282 Effects of indirubin, a GSK3/CDK5 inhibitor, on the Aβ and tau pathways of Alzheimer’s Disease (2006) (0)
- Colloquium Immunotherapy for Alzheimer ’ s disease (2004) (0)
- Observations in transgenic mice expressing human wild-type and A30P-mutated α-synuclein (2000) (0)
- Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia (2018) (0)
- Contents Vol. 27, 2009 (2009) (0)
- IN38-WE-02 Neurogenetics in the new millennium: 2. Dementias (2009) (0)
- Further Analysis of the Nicastrin: Presenilin Complex (2002) (0)
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (0)
- FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-p Interactions Graphical Abstract Highlights (2018) (0)
- Spatially non-uniform condensates emerge from dynamically arrested phase separation (2023) (0)
- A multiplex platform to identify mechanisms and modulators of proteotoxicity in neurodegeneration (2022) (0)
- PROTEINS WHICH INTERACT WITH WILD-TYPE AND MUTANT N-TERMINAL DOMAINS OF HUMAN PrPC (1997) (0)
- Raw data for Qamar et al, FUS Phase Separation, Cell-D-17-01483 (2018) (0)
- Examination of TOMM40, APOE, and PCDH11X in Caribbean Hispanics with late-onset Alzheimer's disease (2009) (0)
- P1-209 APH-1 and PEN-2: a study on their proteolysis (2004) (0)
- O2-02-04: A genomewide screen of 210 extended caribbean hispanic families with late-onset Alzheimer’s disease (2006) (0)
- δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer's-related structural and functional brain changes (2012) (0)
- Wednesday, March 14, 2007 (2007) (0)
- LEVUGLANDINS AS POTENTIALLY NOVEL THERAPEUTIC APPROACHES TO ALZHEIMER’S DISEASE (2006) (0)
- A NOVEL PATTERN OF TAU ISOFORMS IN FAMILIAL PICKʼS DISEASE (1999) (0)
- A novel PS1 mutation in a large aboriginal kindred with early onset familial Alzheimer's disease from a remote community in northern British Columbia (2009) (0)
- 601 Two homologous genes associated with early onset familial Alzheimer's disease (1996) (0)
- Presenilin Function: Connections to Alzheimer's Disease and Signal Transduction (2000) (0)
- Presenilin-Dependent (cid:1) -Secretase-Mediated Control of p53-Associated Cell Death in Alzheimer’s Disease (2006) (0)
- Immunological compositions and methods for treating Alzheimer's disease. (2003) (0)
- P4-115 Molecular analysis of the nicastrin promoter SNPS in Alzheimer's disease (2004) (0)
- P3-392 p24 family proteins have different function in APP processing (2006) (0)
- Genetic Studies of the Alzheimer’s Disease-Associated Amyloid β-Protein Precursor Gene and Familial Alzheimer’s Disease (1989) (0)
- Elucidating the gene expression changes that underpin cholinergic dysfunction in a mouse model of Alzheimer’s disease (2015) (0)
- CJN volume 37 issue 3 Cover and Front matter (2010) (0)
- Biology and genetics of the presenilin proteins associated with alzheimer disease (1997) (0)
- P4-194 Detergent homogenates of spodoptera frugiperda cells display an aspartyl Alzheimer amyloid precursor ɛ-secretase-like activity (2004) (0)
- P4-219: TMP21 association with the γ-secretase complex and its regulation of protease activity (2008) (0)
- Aβ-immunization reduces learning impairment and amyloid plaque burden in an animal model of Alzheimer's disease (2002) (0)
- Genes and Common Diseases: Molecular genetics of Alzheimer's disease and other adult-onset dementias (2007) (0)
- Genome-wide association analysis of Dementia with Lewy bodies reveals unique genetic architecture (2017) (0)
- Presenilins and Alzheimer’s Disease (1998) (0)
- Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death (2020) (0)
- Contents Vol. 18, 2004 (2004) (0)
- P4-305 Identification and characterization of novel cleavage-defective presenilin-1 mutants (2004) (0)
- ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes (2023) (0)
- Subject Index Vol. 22, 2006 (2006) (0)
- S2-02-01: SORL1 and APP sorting (2008) (0)
- P3-225 Role of presenilin-dependent gamma-secretase activity in the control of P53-mediated cell death in Alzheimer’s disease (2006) (0)
- Contents Vol. 22, 2006 (2006) (0)
- Lipid rafts act as a common platform for Aß oligomer-induced Alzheimer’s pathology (2021) (0)
- Investigating the genetic architecture of Dementia with Lewy bodies: a genome-wide association study (2018) (0)
- Apolipoprotein E and Alzheimer’s Disease (1996) (0)
- P3-258: Further evidence of genetic association between SORL1 and Alzheimer's disease (2008) (0)
- O4-03-08 Role of nicastrin in programmed cell death (2004) (0)
- INNOVATIVE APPROACHES IN EPIDEMIOLOGY S1-01-01 APPROACHES TO HARMONIZE NEUROPSYCHOLOGICAL DATA ACROSS STUDIES (2018) (0)
- Genetic sequences and proteins related to alzheimer's disease, and its use of themselves. (1996) (0)
- Genetic Insights from the ADSP into Drug Discovery In Alzheimer’s Disease (2022) (0)
- Genetics, molecular biology, and animal modeling of Alzheimer’s disease (2006) (0)
- Comprar Intracellular Traffic and Neurodegenerative Disorders | St.George-Hyslop, Peter H. | 9783540879404 | Springer (2009) (0)
- O2-06-08: Distinct variants in SORL1 are associated with cerebrovascular and neurodegenerative changes related to Alzheimer's disease (2008) (0)
- DNA profiling of extended tracts of primitive DNA repeats: Direct identification of unstable simple repeat loci in complex genome (1994) (0)
- P4-321 APH-1 intracellular trafficking and its relationship with γ-secretase components (2004) (0)
- P3-171 Genetic analysis of LRRK2 in parkinson disease and Alzheimer disease datasets (2006) (0)
- C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction (2018) (0)
- Molecular genetics of dominant familial Alzheimer's disease (1988) (0)
- P2-318 Inter-rater reliability of neuropsychological assessments used in the Canadian study on genetics of Alzheimer's disease associations (GenADA) (2004) (0)
- Cognitive Characteristics of TgAPP CRND8 Mice Immunised with Beta Amyloid Peptide (2003) (0)
- A rare mutation in the CTNND2 gene is associated with increased Aβ42 secretion (2012) (0)
- Direct identification and cloning of unstable expanded (CCG){sub n} and (CTG){sub n} trinucleotide repeat loci from complex genomes (1995) (0)
- The Presenilins and Alzheimer Disease (2020) (0)
- Analysis of candidate genes of chromosome 12P (2000) (0)
- Genetics of early-onset Alzheimer disease (2001) (0)
- P4-129 Genetic study of APH-1 and PEN-2, components of presenilin high molecular weight complex (2004) (0)
- Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study (2020) (0)
- O2-02-06 Results of fine mapping of a late-onset Alzheimer disease locus on chromosome 12: Linkage and association studies (2006) (0)
- P4-274 Gene expression profiling in the hippocampus of presenilin 1 knockout (PS1/KO) mice (2004) (0)
- P2-060 Metabolism of transgenic mutant APP varies according to background mouse strain (2004) (0)
- The Role of Neurofilament Genes in Familial Alzheimer's Disease (1987) (0)
- Genome-Wide Analysis of Large Rare Copy Number Variations in Alzheimer Disease Among Caribbean Hispanics (2011) (0)
- Longitudinal evaluation of TauP 301 L transgenic mice reveals no cognitive impairments at 17 months of age Journal Item (2019) (0)
- Genetics and biology of the presenilins and their interacting proteins (2000) (0)
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