Philip Handler

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Philip Handler is affiliated with the following schools: University of California, Berkeley, City College of New York, University of Illinois Urbana-Champaign, Duke University

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Philip Handler

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Philip Handler

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Biochemistry

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Why Is Philip Handler Influential?

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According to Wikipedia, Philip Handler was an American nutritionist, and biochemist. He was President of the United States National Academy of Sciences for two terms from 1969 to 1981. He was also a recipient of the National Medal of Science.

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Philip Handler's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Biosynthesis of diphosphopyridine nucleotide. II. Enzymatic aspects. (1958) (300)
Biosynthesis of diphosphopyridine nucleotide. I. Identification of intermediates. (1958) (280)
Hepatic aldehyde oxidase. I. Purification and properties. (1962) (225)
Xanthine oxidase. V. Differential inhibition of the reduction of various electron acceptors. (1962) (165)
Enzymatic synthesis of nicotinamide mononucleotide. (1957) (144)
Detection of free radicals generated during enzymic oxidations by the initiation of sulfite oxidation. (1961) (140)
Purification and properties of chicken liver xanthine dehydrogenase. (1967) (126)
Amino acid and protein metabolism. (1957) (117)
Kinetics of ammonia metabolism in vivo. (1958) (113)
Fatty Liver Induced by Orotic Acid Feeding (1955) (108)
XANTHINE OXIDASE. VI. INFLUENCE OF PH ON SUBSTRATE SPECIFICITY. (1964) (108)
A colorimetric micromethod for determination of ammonia; the ammonia content of rat tissues and human plasma. (1957) (107)
Competitive inhibition of enzyme activity by urea. (1961) (104)
Biosynthesis of Diphosphopyridine Nucleotide (1958) (101)
HEPATIC ALDEHYDE OXIDASE. 3. THE SUBSTRATE-BINDING SITE. (1964) (100)
HEPATIC ALDEHYDE OXIDASE. II. DIFFERENTIAL INHIBITION OF ELECTRON TRANSFER TO VARIOUS ELECTRON ACCEPTORS. (1964) (96)
Chemiluminescence induced by operation of iron-flavoproteins. (1962) (92)
Purification and properties of hepatic sulfite oxidase. (1961) (90)
The metabolism of parenterally administered amino acids. II. Urea synthesis. (1951) (83)
Xanthine oxidase. III. Sulfite oxidation as an ultra sensitive assay. (1958) (80)
Effect of infusion of single amino acids upon excretion of other amino acids. (1951) (78)
Xanthine oxidase. IV. Participation of iron in internal electron transport. (1958) (77)
Biosynthesis of trigonelline. (1960) (75)
PHOSPHOGLUCOMUTASE. I. PURIFICATION AND PROPERTIES OF PHOSPHOGLUCOMUTASE FROM ESCHERICHIA COLI. (1964) (69)
Mechanism of Thiamine-catalyzed Reactions1 (1954) (66)
Biology and the Future of Man (1970) (64)
Purification and Properties of Xanthine Dehydrogenase from Micrococcus lactilyticus (1967) (64)
Partial purification and properties of renal glutaminase. (1958) (64)
The presence of two species of DNA in some halobacteria. (1963) (61)
Preparation of bovine xanthine oxidase and the subunit structures of some iron flavoproteins. (1968) (60)
The role of molybdenum in xanthine oxidase and related enzymes. Reactivity with cyanide, arsenite, and methanol. (1969) (57)
THE ABSORPTION SPECTRA OF IRON-FLAVOPROTEINS. (1964) (57)
Purification and properties of nicotinamidase from Torula cremoris. (1962) (56)
Methods in enzymology. Vol. III: Edited by S. P. Colowick and N. O. Kaplan, McCollum-Pratt Institute, The Johns Hopkins University, Baltimore, Maryland. Academic Press Inc., New York, New York, 1957. 1154 pp. Price $26.00 (1957) (56)
The enzymatic oxidation of sulfite. (1953) (54)
Effect of parathyroid extract on renal function. (1952) (54)
THE INHIBITION OF RAT GROWTH BY NICOTINAMIDE (1942) (53)
Dihydroorotate dehydrogenase. I. General properties. (1967) (51)
KINETICS OF BEEF HEART GLUTAMIC-ALANINE TRANSAMINASE. (1965) (48)
Studies on the dissociation of flavin adenine dinucleotide from metalloflavoproteins. (1972) (48)
Biosynthesis of diphosphopyridine nucleotide. III. Nicotinic acid mononucleotide pyrophos-phorylase. (1961) (47)
Xanthine oxidase. II. Studies of the active site. (1958) (46)
The inactivation of pyridine nucleotides by animal tissues in vitro. (1942) (45)
Detection of free radicals in illuminated dye solutions by the initiation of sulfite oxidation. (1960) (45)
Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. I. Spectra at equilibrium states. (1968) (43)
The significance of fatty infiltration in the development of hepatic cirrhosis due to choline deficiency. (1946) (38)
Colorimetric Assay for Reaction of Sulfhydryl Groups with Organic Mercurials (1957) (36)
Synthesis of nicotinamide mononucleotide by human erythrocytes in vitro. (1951) (36)
The metabolism of parenterally administered amino acids; glycine. (1948) (35)
The effects of various inhibitors of carbohydrate metabolism in vivo. (1945) (35)
The metabolism of parenterally administered amino acids. III. Ammonia formation. (1951) (35)
The influence of thyroid activity on the liver and plasma lipides of choline- and cystine-deficient rats. (1948) (34)
THE OXIDATIVE DEMETHYLATION OF SARCOSINE TO GLYCINE (1941) (33)
Isolation from the mushroom Agaricus bisporus and chemical synthesis of gamma-L-glutaminyl-4-hydroxybenzene. (1971) (32)
INTERMEDIATES IN THE SYNTHESIS OF DIPHOSPHOPYRIDINE NUCLEOTIDE FROM NICOTINIC ACID1 (1957) (31)
The biochemical defect underlying the nutritional failure of young rats on diets containing excessive quantities of lactose or galactose. (1947) (31)
Choline Deficiency in the Hamster (1949) (31)
Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. II. Kinetic studies by rapid freezing. (1968) (30)
SYNTHESIS OF DIPHOSPHOPYRIDINE NUCLEOTIDE FROM NICOTINIC ACID BY HUMAN ERYTHROCYTES IN VITRO1 (1957) (29)
THE QUANTITATIVE ESTIMATION OF NICOTINIC ACID IN ANIMAL TISSUES (1941) (29)
Phosphoglucomutase. 3. Purification and properties of phosphoglucomutases from flounder and shark muscle. (1966) (28)
Phosphoglucomutase. V. Multiple forms of phosphoglucomutase. (1967) (28)
Effect of parathyroid extract on renal excretion of phosphate. (1951) (27)
Phosphoglucomutase. II. Preparation and properties of phosphoglucomutases from Micrococcuus lysodeikticus and Bacillus cereus. (1966) (26)
Public doubts about science. (1980) (26)
The initial step in enzymatic sulfite oxidation. (1956) (26)
Use of radiophosphorus in studies of glomerular permeability of plasma inorganic phosphate. (1951) (26)
Effect of presence of other amino acids upon intestinal absorption of single amino acids in the rat. (1952) (26)
Gamma-L-glutaminyl-3,4-benzoquinone. Structural studies and enzymatic synthesis. (1971) (24)
Importance of dietary protein, calories and salt in experimental renal hypertension. (1949) (21)
Isolation of -L-glutaminyl 4-hydroxybenzene and -L-glutaminyl 3,4-benzoquinone: a natural sulfhydryl reagent, from sporulating gill tissue of the mushroom Agaricus bisporus. (1970) (21)
Purification and Properties of Inosinic Acid Dehydrogenase from Escherichia coli (1969) (21)
Metabolism of trigonelline. (1962) (20)
Mechanism of action of a respiratory inhibitor from the gill tissue of the sporulating common mushroom, Agaricus bisporus. (1972) (20)
The mechanism of cozymase synthesis in the human erythrocyte. A comparison of the roles of nicotinic acid and nicotinamide. (1943) (20)
Phosphoglucomutase. IV. Inactivation by beryllium ions. (1967) (20)
SPECIFICITY OF THE d-AMINO ACID OXIDASE (1941) (20)
The effect of excessive nicotinamide feeding on rabbits and guinea pigs. (1944) (20)
THE TOXICITY OF ORALLY ADMINISTERED TANNIC ACID. (1944) (20)
Physiological basis for effects of low-protein diets on blood pressure of subtotally nephrectomized rat. (1950) (18)
ANIMAL EXPERIMENTS WITH TANNIC ACID: SUGGESTED BY THE TANNIC ACID TREATMENT OF BURNS. (1943) (18)
Dietary factors in the regulation of liver lipid concentration. (1946) (17)
EFFECT OF DIPHOSPHOPYRIDINE NUCLEOTIDE ON THE RATE OF OXIDATION OF BETAINE ALDEHYDE (1942) (17)
Oxidation of phenazine methosulfate by hepatic aldehyde oxidase. (1962) (17)
Preparation of several forms of xanthine oxidase by enzymic proteolysis. (1961) (16)
Phosphoglucomutase. VI. Purification and properties of phosphoglucomutases from human muscle. (1969) (16)
SYNTHESIS OF NICOTINIC ACID BY THE CHICK EMBRYO (1941) (16)
Electron paramagnetic resonance studies of iron reduction and semiquinone formation in metalloflavoproteins. (1962) (16)
Response of Guinea Pigs to Diets Deficient in Choline. (1949) (16)
AZLACTONES I. PREPARATION OF BENZOYL-α-AMINOCROTONIC ACID AZLACTONE AND THE CONVERSION OF ALLOTHREONINE TO THREONINE (1939) (15)
Science and the Federal Government (1969) (15)
Utilization of the photosensitized oxidation of sulfite for manometric actinometry. (1959) (15)
Influence of dietary factors on hypertension induced by choline deficiency. (1950) (14)
THE SPECIFICITY OF l(—)-METHIONINE IN CREATINE SYNTHESIS (1943) (14)
Instrumental Artifacts in the Determination of Difference Spectra (1957) (14)
Hypoxanthine as a cofactor for the enzymatic oxidation of sulfite. (1956) (14)
[68] Aldehyde oxidase (1966) (14)
The Nicotinic Acid Content of Meat (1942) (13)
Renal phosphate and carbohydrate metabolism studied with the aid of radiophosphorus. (1952) (13)
The role of thyroid activity in the pathogenesis of hepatic lesions due to choline and cystine deficiency. (1948) (13)
THE METABOLISM OF PARENTERALLY ADMINISTERED AMINO ACIDS (1951) (13)
Factors affecting the occurrence of hemorrhagic kidneys due to choline deficiency. (1946) (12)
Xanthine oxidase. I. The oxidation of sulfite. (1957) (11)
Studies on dihydroorotate dehydrogenase by electron paramagnetic resonance spectroscopy. II. Electron paramagnetic resonance and optical spectra and titrations. (1968) (11)
STRUCTURE AND FUNCTION OF IRON-FLAVOPROTEINS. (1964) (11)
The Utilization of the Calcium of Cauliflower and Broccoli (1940) (11)
Studies on dihydroorotate dehydrogenase by electron paramagnetic resonance spectroscopy. 3. Kinetic studies by rapid freezing. (1968) (10)
THE OXIDATION IN VITRO OF N-METHYLAMINO ACIDS BY KIDNEY AND LIVER (1941) (10)
Effects of Parathyroid Extract on Sulfate Metabolism of Cartilage and Bone Matrix of Rachitic Rats.∗ (1958) (9)
The effects of insulin in fluoride-poisoned rats. (1946) (9)
Apparent adenylate kinase activity in vivo. (1953) (9)
The effects of caloric restriction on skeletal growth. (1947) (9)
Effects of caloric restriction, salt restriction, and role of pituitary and adrenal glands in experimental renal hypertension. (1951) (8)
The choline oxidase activity of fatty livers. (1942) (8)
Effect of choline deficiency on ACTH production and on hypertension of subtotally nephrectomized rats. (1950) (8)
The Federal overnment and the scientific community. (1971) (8)
Comparative Aspects of the Structure and Function of Phosphoglucomutase (1965) (8)
The nicotinic acid and coenzyme content of the tissues of normal and blacktongue dogs. (1941) (7)
Mechanism of the factitious stimulation of biological oxidations by hypoxanthine. (1961) (7)
AZLACTONES III. ACYLATION OF AMINO ACIDS IN PYRIDINE (1941) (7)
Influence of Age on Hepatic Response to Choline and Cystine Deficiency in the Rat.∗ (1950) (7)
THE EFFECT OF SIMULTANEOUS MINERAL AND CHOLINE DEFICIENCIES ON LIVER FAT (1943) (6)
THE FUTURE OF AMERICAN SCIENCE. (6)
Influence of sulfhydryl compounds on the equilibrium of the alcohol dehydrogenase reaction. (1957) (6)
Use of Highly Purified Rations in the Study of Nicotinic Acid Deficiency. (1943) (6)
Lipodystrophy intestinalis (Whipple's disease). (1948) (6)
Pangs of science (1978) (5)
The Reaction of Formaldehyde with Amino Acids: X-ray Diffraction Patterns. (1940) (5)
Metabolism of methylnicotinamide by the livers of rats, rabbits and guinea pigs in vitro. (1952) (5)
Basic Research in the United States (1979) (5)
Inactivity of Nicotinuric Acid in Canine Blacktongue (1941) (4)
Hypovitaminosis A. (1958) (4)
The World We Want. (1970) (4)
On carcinogenesis. (1982) (4)
Pruning the federal science budget. (1981) (4)
XANTHINE OXIDASE. VII. INHIBITION BY AMINO GROUP REAGENTS. (1964) (4)
Metabolic complexities of pellagra. (1947) (4)
Effect of Renal Decapsulation on Hypertension Induced by Single Episode of Acute Choline Deficiency.∗ (1951) (4)
Hypoxanthine, cofactor for cysteine oxidation by liver preparations. (1956) (4)
Oxidation of Some Substituted Alcohols by Rat Liver (1941) (3)
Paul M. Gross, President-Elect. (1961) (3)
Sulfite metabolism in E. coli. (1956) (3)
Commentary: On the State of Man (1975) (3)
NATIONAL PLANNING FOR MEDICAL RESEARCH. (1965) (3)
Whither American science? (1974) (3)
The American University Today (1976) (3)
Academic science and the Federal Government. (1967) (3)
Federal science policy. (1967) (3)
On the State of Man. (1975) (3)
Sociotechnology: Science, technology, and the human condition: The impact of science and engineering on citizens is great, despite their questionable impact on social institutions (1979) (2)
Influence of previous dietary protein and of ACTH on blood glucose concentration of fasting rats. (1950) (2)
Cuff for Use with Endpoint Devices for Estimation of Arterial Blood Pressure of the Rat.∗ (1957) (2)
Biochemical considerations of relationships between effects of time and of radiation on living systems. (1961) (2)
THE NICOTINIC ACID AND COENZYME CONTENT OF ANIMAL TISSUES (1941) (2)
Overview of Policy Issues: Panel Report (1979) (2)
The present status of nicotinic acid. (1947) (2)
Protein as a metabolic fuel. (1952) (2)
The future of the scientific endeavor. (1980) (2)
[131] Sulfite cytochrome c reductase: 2 Ferricytochrome c + SO3 + H2O = SO4 + 2 Ferrocytochrome c + 2H+ SO3 + 12 O2 = SO4 (1962) (1)
Stimulation by dinitrophenol of formation of melanin-like substance from tyrosine by rat liver homogenates. (1957) (1)
Purification and properties of xanthine dehydroganase from Micrococcus lactilyticus. (1967) (1)
[122] Nicotinamide deamidase from Torula cremoris (1971) (1)
The metabolism of parenterally administered amino acids; glycine. (1949) (1)
THE EFFECT OF CHOLINE DEFICIENCY ON THE FAT CONTENT OF REGENERATED LIVER (1943) (1)
Dietary factors in experimental renal hypertension; protein. (1948) (1)
Women Scientists: Steps in the Right Direction (1978) (1)
Pressor factor in normal human urine. (1956) (1)
Health care and the unity of science. (1972) (1)
Science, technology, and social achievement (1979) (1)
The Dispersion of Protein in Aqueous Formaldehyde Solutions. (1939) (1)
Science's Continuing Role (1970) (1)
Ammonia production by kidney slices of normal, acidotic and alkalotic rats. (1949) (1)
A Voice of Conscience Is Stilled (1973) (1)
Council of U.S. Academy of Sciences Expresses Concern to Soviet Counterparts over Sakharov Harrassment. (1973) (1)
Indoleacetic Acid and Growth of Bacteria with Varying Requirements for Nicotinic Acid and Tryptophane (1947) (1)
In defense of science. (1971) (1)
Comparative Studies of Phosphoglucomutase. (1965) (1)
On the inducibility of a pancreatic lactase (1969) (1)
Statement by Philip Handler. . . Before the Subcommittee on Science, Research, and Technology, Committee on Science and Technology, House of Representatives (1979) (1)
Chemical Background for the Biological Sciences. Emil H. White. Prentice-Hall, Englewood Cliffs, N.J., 1964. viii + 152 pp. Illus. Paper, $1.95; cloth, $4.95 (1964) (0)
Graudate training in dermatology. Where is dermatology going in the next ten years? Discussion. (1969) (0)
architecture appropriate to the conduct of science1 (1967) (0)
The Ohio State University Commencement Address by Philip Handler, Winter 1978 (1978) (0)
SCIENCE AND THE DEVELOPING NATIONS (1976) (0)
Metabolism of N-Alkyl Derivatives of Amino Acids (1939) (0)
Graduate training in dermatology. Science and the federal government. (1969) (0)
OSBORNE and Mendel award. (1952) (0)
On the Life Sciences (1971) (0)
Other Reactions in the Science Community (1969) (0)
Science Policy: Pangs of Science. (1978) (0)
Science and the Public: The End of an Affair?. (1980) (0)
PHOSPHOGLUCOM(UTASE, V. MULTIPLE FORMS OF PHOSPHOGL( [COAL UTASE (0)
Boycott Helsinki meeting (1980) (0)
Contributions of biochemical research to progress in medicine. (1961) (0)
Environment: fanning the flames. (1971) (0)
Chemistry and Biology: Chemical Background for the Biological Sciences . Emil H. White. Prentice-Hall, Englewood Cliffs, N.J., 1964. viii + 152 pp. Illus. Paper, $1.95; cloth, $4.95. (1964) (0)
Methods in enzymology. Volume IV: Edited by Sidney P. Colowick and Nathan O. Kaplan, McCollum Pratt Institute, Johns Hopkins University, Baltimore, Maryland. Academic Press Inc., New York, New York, 1957. xii + 979 pp. Price $24.00 (1958) (0)
Science in a Democratic Society On the Need for Poets and Philosophers (1981) (0)
Fatty infiltration, necrosis, and scarring of the liver produced by dietary means and modified by thyroid activity. (1947) (0)
Annual Report of the President, National Academy of Sciences, 22 April 1980 (1980) (0)
The Physical Sciences. Report of the National Science Board Submitted to the Congress. (1970) (0)
Catalytic Action of 8-Hydroxyquinoline on the Oxidation of p-Phenylenediamine (1940) (0)
William John Dann 1904-1948. (1949) (0)
Influence of thyroid activity on liver lipids in choline and cystine deficiency. (1947) (0)
Nitrogen balance. (1947) (0)
The status of American science. (1980) (0)
Problems in Energy Metabolism (1966) (0)
Letter from Philip Handler to the National Academy of Sciences (1980) (0)
Response : Environment: Fanning the Flames (1971) (0)
Tryptophan-poor diets. (1976) (0)
Radical chic and the liberation of the reader (1975) (0)
Statement by Philip Handler. . . Before Conference on Security and Cooperation in Europe (1980) (0)
[44] Synthesis of diphosphopyridine nucleotide from nicotinic acid (1963) (0)
Congressional Research Support of Indirect Costs (1969) (0)
Anniversary Dinner 1976: speech by Dr Philip Handler, President of the U. S. National Academy of Sciences, The Dorchester, 30 November 1976 (1977) (0)
Letter from Philip Handler to Joshua Lederberg (1970) (0)
Symposium on Enzyme Reaction Mechanisms: summarizing remarks. (1959) (0)
Science, food and man's future. (1971) (0)
Letter from Philip Handler, National Academy of Sciences to Joshua Lederberg (1966) (0)
Problems in Energy Metabolism: Mechanisms in Bioenergetics . Efraim Racker. Academic Press, New York, 1965. 271 pp., illus. Paper, $3.45; cloth, $6.50. (1966) (0)
Responding to Literature; Guide to the Film Series. Protokollon. (1975) (0)
Sulfhydryl Reagent, from Sporulating Gill Tissue of the Mushroom Agaricus bisporus* (0)
BIOCHEMICAL EVOLUTION. INTRODUCTORY REMARKS. (1964) (0)
Toward a National Science Policy? (1970) (0)
Alleviation by Raw Liver of Anorexia Produced by Sulfapyridine (1944) (0)
A fluorimetric assay for N1-methyl-6-pyridone-3-carboxylamide. (1948) (0)
Congressional research support of indirect costs. (1969) (0)
RADIATION AND AGING. Synopses of Panel Discussions Held During 1958 and 1959 (1961) (0)
Science and the Federal government: which way to go. (1970) (0)
Of Questions and Committees (1978) (0)
Handler's "Dissent" Explained (1971) (0)
The significance of parathyroid activity in physiological regulation of acid-base balance. (1947) (0)
William John Dann 1904-1948 (1949) (0)
Creative Responses to Literature: Imagining, Personalizing, Clarifying, Valuing; Guide to the Film Series. Protokollon II. (1975) (0)
Sulfite oxidation in rat liver. (1958) (0)
Graduate School Support (1969) (0)
Science and public policy. (1966) (0)
OPPORTUNITIES FOR SCIENCE AND SCIENTISTS (1972) (0)
Isolation of yL-Glutaminyl 4-Hydroxybenzene and 7 yL-Glutaminyl 3 , 4-Benzoquinone : a Natural Sulfhydryl Reagent , from Sporulating Gill Tissue of the Mushroom Agaricus bisporus * (0)
SCIENCE AND PUBLIC POLICY. PRELIMINARY REMARKS. (1964) (0)
The failure of skeletal calcification produced by high lactose diets and by simple caloric restriction. (1946) (0)
Remarks on the conduct of science in the environment of the 1970's (1970) (0)
Between complacency and panic. (1973) (0)
Science Can Make Our Dreams Come True (1971) (0)

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Published Works

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What Schools Are Affiliated With Philip Handler?

Philip Handler's AcademicInfluence.com Rankings