Richard W. Aldrich
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Neuroscientist
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Richard W. Aldrichbiology Degrees
Biology
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#4505
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#1236
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Neuroscience
#519
World Rank
#539
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#158
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Biology
Richard W. Aldrich's Degrees
- Doctorate Medicine Stanford University
Why Is Richard W. Aldrich Influential?
(Suggest an Edit or Addition)According to Wikipedia, Richard Warren Aldrich is an American neuroscientist who is currently the Karl Folkers Chair of Interdisciplinary Medical Research and Professor of Neurobiology in the School of Biological Sciences at the University of Texas.
Richard W. Aldrich's Published Works
Published Works
- International Union of Pharmacology. LII. Nomenclature and Molecular Relationships of Calcium-Activated Potassium Channels (2005) (860)
- Vasoregulation by the β1 subunit of the calcium-activated potassium channel (2000) (832)
- Two types of inactivation in Shaker K+ channels: Effects of alterations in the carboxy-terminal region (1991) (690)
- A reinterpretation of mammalian sodium channel gating based on single channel recording (1983) (657)
- Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. (1993) (605)
- Shaker potassium channel gating. III: Evaluation of kinetic models for activation (1994) (518)
- Cloning and Functional Characterization of Novel Large Conductance Calcium-activated Potassium Channel β Subunits, hKCNMB3 and hKCNMB4* (2000) (499)
- Local potassium signaling couples neuronal activity to vasodilation in the brain (2006) (491)
- Coupling between Voltage Sensor Activation, Ca2+ Binding and Channel Opening in Large Conductance (BK) Potassium Channels (2002) (464)
- Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels. (1991) (435)
- Expression cloning of a rat B2 bradykinin receptor. (1991) (399)
- Overactive Bladder and Incontinence in the Absence of the BK Large Conductance Ca2+-activated K+ Channel* (2004) (349)
- BK channel β4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures (2005) (328)
- Shaker potassium channel gating. II: Transitions in the activation pathway (1994) (324)
- Intrinsic Voltage Dependence and Ca2+ Regulation of mslo Large Conductance Ca-activated K+ Channels (1997) (317)
- Voltage-dependent gating of Shaker A-type potassium channels in Drosophila muscle (1990) (285)
- Allosteric Gating of a Large Conductance Ca-activated K+ Channel (1997) (280)
- Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction (2010) (276)
- Allosteric Voltage Gating of Potassium Channels I: Mslo Ionic Currents in the Absence of Ca2+ (1999) (268)
- Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase activation. (1988) (249)
- International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (2005) (243)
- Mutations in the S4 Region Isolate the Final Voltage-dependent Cooperative Step in Potassium Channel Activation (1999) (241)
- Molecular determinants of voltage-dependent inactivation in calcium channels (1994) (239)
- BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output (2006) (235)
- Influence of conservation on calculations of amino acid covariance in multiple sequence alignments (2004) (235)
- Multiple Structural Elements in Voltage-Dependent Ca2+ Channels Support Their Inhibition by G Proteins (1996) (220)
- LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium (2010) (213)
- Shaker potassium channel gating. I: Transitions near the open state (1994) (210)
- Single-Channel Recording (1983) (207)
- Inactivation of delayed outward current in molluscan neurone somata. (1979) (197)
- Allosteric Voltage Gating of Potassium Channels II: Mslo Channel Gating Charge Movement in the Absence of Ca2+ (1999) (193)
- Functional stoichiometry of Shaker potassium channel inactivation. (1993) (191)
- Role of the β1 Subunit in Large-Conductance Ca2+-Activated K+ Channel Gating Energetics (2000) (181)
- BK potassium channel modulation by leucine-rich repeat-containing proteins (2012) (180)
- Uncharged S4 Residues and Cooperativity in Voltage-dependent Potassium Channel Activation (1998) (167)
- Mechanism of frequency‐dependent broadening of molluscan neurone soma spikes. (1979) (160)
- Single-channel and genetic analyses reveal two distinct A-type potassium channels in Drosophila. (1987) (157)
- Cooperative subunit interactions in C-type inactivation of K channels. (1995) (153)
- β1‐Subunit of the Ca2+‐activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle (2001) (148)
- Interactions of amino terminal domains of Shaker K channels with a pore blocking site studied with synthetic peptides (1993) (148)
- Role of the S4 in Cooperativity of Voltage-dependent Potassium Channel Activation (1998) (147)
- Erectile dysfunction in mice lacking the large‐conductance calcium‐activated potassium (BK) channel (2005) (141)
- Gating of single Shaker potassium channels in Drosophila muscle and in Xenopus oocytes injected with Shaker mRNA. (1989) (140)
- Voltage-dependent gating of single sodium channels from mammalian neuroblastoma cells (1987) (140)
- Allosteric linkage between voltage and Ca(2+)-dependent activation of BK-type mslo1 K(+) channels. (2000) (134)
- A perturbation-based method for calculating explicit likelihood of evolutionary co-variance in multiple sequence alignments (2004) (134)
- Immunolocalization of the Ca2+‐activated K+ channel Slo1 in axons and nerve terminals of mammalian brain and cultured neurons (2006) (130)
- Determination of parameter identifiability in nonlinear biophysical models: A Bayesian approach (2014) (124)
- THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels (2021) (122)
- Regulation of Shaker K+ channel inactivation gating by the cAMP-dependent protein kinase (1994) (111)
- Energetics of Shaker K channels block by inactivation peptides (1993) (106)
- The Molecular Mechanism of “Ryegrass Staggers,” a Neurological Disorder of K+ Channels (2008) (103)
- Role of the beta1 subunit in large-conductance Ca(2+)-activated K(+) channel gating energetics. Mechanisms of enhanced Ca(2+) sensitivity. (2000) (100)
- Voltage-dependent K+ currents and underlying single K+ channels in pheochromocytoma cells (1988) (98)
- Functional Consequences of a Decreased Potassium Affinity in a Potassium Channel Pore (1999) (93)
- State-independent Block of BK Channels by an Intracellular Quaternary Ammonium (2006) (92)
- Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder. (2005) (91)
- Profiling the Phospho-status of the BKCa Channel α Subunit in Rat Brain Reveals Unexpected Patterns and Complexity*S (2008) (86)
- On Evolutionary Conservation of Thermodynamic Coupling in Proteins* (2004) (85)
- Calcium activation of BKCa potassium channels lacking the calcium bowl and RCK domains (2002) (84)
- Extrasynaptic Localization of Inactivating Calcium-Activated Potassium Channels in Mouse Inner Hair Cells (2004) (82)
- Unique Inner Pore Properties of BK Channels Revealed by Quaternary Ammonium Block (2004) (79)
- Conserved properties of individual Ca2+-binding sites in calmodulin (2016) (79)
- Cochlear Function in Mice Lacking the BK Channel α, β1, or β4 Subunits* (2007) (77)
- Convergent evolution of alternative splices at domain boundaries of the BK channel. (2009) (77)
- Inactivation of voltage-gated delayed potassium current in molluscan neurons. A kinetic model. (1981) (75)
- Beta-adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+ channel. (2008) (75)
- Preferential Interaction of ω-Conotoxins with Inactivated N-type Ca2+ Channels (1997) (72)
- Beta1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle. (2001) (71)
- Inactivation of open and closed sodium channels determined separately. (1983) (70)
- Frequency encoding of cholinergic- and purinergic-mediated signaling to mouse urinary bladder smooth muscle: modulation by BK channels. (2007) (70)
- Separation of Gating Properties from Permeation and Block in mslo Large Conductance Ca-activated K+ Channels (1997) (69)
- Coordination to lanthanide ions distorts binding site conformation in calmodulin (2018) (66)
- EF hands at the N-lobe of calmodulin are required for both SK channel gating and stable SK–calmodulin interaction (2009) (65)
- Fifty years of inactivation (2001) (64)
- International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels (2017) (63)
- Conversion of a Delayed Rectifier K+ Channel to a Voltage-Gated Inward Rectifier K+ Channel by Three Amino Acid Substitutions (1996) (63)
- A Mutation in S6 of Shaker Potassium Channels Decreases the K+ Affinity of an Ion Binding Site Revealing Ion–Ion Interactions in the Pore (1998) (61)
- A peptide derived from the shaker B K+ channel produces short and long blocks of reconstituted Ca2+-dependent K+ channels (1992) (57)
- Na+ channel function, regulation, structure, trafficking and sequestration (2015) (57)
- Alterations in the expression and gating of drosophila sodium channels by mutations in the para gene (1989) (55)
- Cochlear function in mice lacking the BK channel alpha, beta1, or beta4 subunits. (2007) (54)
- Allosteric Voltage Gating of Potassium Channels I (1999) (50)
- Complex voltage-dependent behavior of single unliganded calcium-sensitive potassium channels. (2000) (49)
- Determinants of Voltage-Dependent Gating and Open-State Stability in the S5 Segment of Shaker Potassium Channels (1999) (47)
- Relationship between Pore Occupancy and Gating in BK Potassium Channels (2006) (46)
- Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating (2011) (44)
- BK channel opening involves side-chain reorientation of multiple deep-pore residues (2013) (43)
- Analyzing single-molecule time series via nonparametric Bayesian inference. (2015) (42)
- Voltage-dependent Gating of Single Wild-Type and S4 Mutant KAT1 Inward Rectifier Potassium Channels (1998) (41)
- Gating kinetics of four classes of voltage-dependent K+ channels in pheochromocytoma cells (1988) (40)
- Alternatively spliced domains interact to regulate BK potassium channel gating (2011) (40)
- Intragenic alternative splicing coordination is essential for Caenorhabditis elegans slo-1 gene function (2011) (40)
- State-dependent Block of BK Channels by Synthesized Shaker Ball Peptides (2006) (38)
- Mixing and matching (1990) (38)
- Gating of single non-Shaker A-type potassium channels in larval Drosophila neurons (1990) (37)
- The International Legal Implications of Information Warfare (1996) (35)
- Properties of ShB AType potassium channels expressed in Shaker mutant drosophil by germline transformation (1989) (33)
- Allosteric Voltage Gating of Potassium Channels II (1999) (33)
- Analysis of Nonstationary Channel Kinetics (1983) (31)
- Advent of a new family (1993) (29)
- Electrostatic influences of charged inner pore residues on the conductance and gating of small conductance Ca2+ activated K+ channels (2011) (29)
- Hypercontractility and impaired sildenafil relaxations in the BKCa channel deletion model of erectile dysfunction. (2008) (28)
- Preferential interaction of omega-conotoxins with inactivated N-type Ca2+ channels. (1997) (27)
- In vitro calibration of the equilibrium reactions of the metallochromic indicator dye antipyrylazo III with calcium. (1987) (26)
- Voltage-dependent gating of sodium channels: towards an integrated approach (1986) (25)
- Differences in gating among amino-terminal variants of Shaker potassium channels. (1990) (25)
- Binding of a Gating Modifier Toxin Induces Intersubunit Cooperativity Early in the Shaker K Channel's Activation Pathway (2006) (24)
- Statistical Limits to the Identification of Ion Channel Domains by Sequence Similarity (2006) (23)
- A Gastropod Toxin Selectively Slows Early Transitions in the Shaker K Channel's Activation Pathway (2004) (23)
- Calcium-dependent stoichiometries of the KCa2.2 (SK) intracellular domain/calmodulin complex in solution (2014) (22)
- Activation of the SK potassium channel-calmodulin complex by nanomolar concentrations of terbium (2009) (20)
- Structural identifiability of equilibrium ligand-binding parameters (2017) (17)
- Properties of ShB A-type potassium channels expressed in Shaker mutant Drosophila by germline transformation. (1989) (17)
- Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels. (2018) (16)
- Potassium Channels: New channel subunits are a turn-off (1994) (16)
- Modification of Cyclic Nucleotide–Gated Ion Channels by Ultraviolet Light (2000) (16)
- The structure of binding curves and practical identifiability of equilibrium ligand-binding parameters (2017) (14)
- Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation (2020) (13)
- Functional assay of a putative Drosophila sodium channel gene in homozygous deficiency neurons. (1992) (13)
- Cyberterrorism and Computer Crimes: Issues Surrounding the Establishment of an International Legal Regime (2000) (12)
- A novel BK channel-targeted peptide suppresses sound evoked activity in the mouse inferior colliculus (2017) (11)
- Ancestral reconstruction of protein interaction networks (2018) (11)
- Effects of Ultraviolet Modification on the Gating Energetics of Cyclic Nucleotide–Gated Channels (2000) (10)
- Non-Additive Effects of Binding Site Mutations in Calmodulin. (2019) (9)
- How Do You Know You Are at War in the Information Age (2000) (9)
- Calcium- and sodium-activated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (7)
- Tissue-specific N Terminus of the HCN4 Channel Affects Channel Activation (2011) (7)
- For the Latest Information, Tune to Channel KcsA (1999) (7)
- Mutating and gating (1989) (5)
- A Novel Auxiliary Protein Allows BK Potassium Channel Activation at Resting Voltage Without Calcium (2010) (5)
- Effects on Ion Permeation with Hydrophobic Substitutions at a Residue in Shaker S6 That Interacts with a Signature Sequence Amino Acid (1999) (5)
- Acknowledgment of Reviewers, 2016 (2016) (5)
- BK Channel Modulation by Leucine-Rich Repeat Containing Proteins (2012) (5)
- Closed state-coupled C-type inactivation in BK channels (2016) (4)
- Potassium channels. Advent of a new family. (1993) (4)
- Potassium channels. Mixing and matching. (1990) (4)
- Influences: Growing up in Yale Physiology (2018) (3)
- New channel subunits are a turn-off Recent discoveries indicate that potassium channel 3 subunits can have profound functional roles, particularly in determining the channel inactivation properties. (1994) (3)
- A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo (2018) (3)
- Mapping Functional Protein Neighborhoods in the Mouse Brain (2020) (3)
- A new standard: A review of Handbook of Ion Channels (2015) (3)
- Preferential Interaction of v-Conotoxins with Inactivated N-type Ca 2 1 Channels (1997) (2)
- 5 – Single Potassium Channels in Drosophila Nerve and Muscle (1989) (2)
- b 1-Subunit of the Ca 2 +-activated K + channel regulates contractile activity of mouse urinary bladder smooth muscle (2007) (2)
- Shaker Potassium Channel Gating Evaluation of Kinetic Models for Activation III : (2003) (2)
- Site-Specific Measurement of Terbium and Calcium Binding to Calmodulin and Calmodulin Fragments (2013) (2)
- Ion Transport through Ligand-Gated Channels (1986) (1)
- Ion channels. Mutating and gating. (1989) (1)
- Erratum: BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output (2006) (1)
- Na+ channel regulation, structure, trafficking and sequestration (2015) (1)
- Roles of BK and Kir channels in the coupling of neural activity to vasodilation in the somatosensory cortex in vivo (2008) (1)
- Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2021.3 (2021) (1)
- On Parameter Identifiability in Non-Linear Biophysical Models (2013) (1)
- Hyper-contractility and impaired cGMP signaling in the BKCa channel deletion model of erectile dysfunction (2007) (1)
- Closed State Coupled C-Type Inactivation in BK Channels (2014) (1)
- Role of the b 1 Subunit in Large-Conductance Ca 2 1 -activated K 1 Channel Gating Energetics Mechanisms of Enhanced Ca 2 1 Sensitivity (2000) (1)
- 3245-Plat Calcium-Dependent Gating in MthK K D Channels Occurs at the Selectivity Filter (2014) (0)
- Lipid Bilayer Perturbation by the Snail Toxin 6-Bromo-2-Mercaptotryptamine Dimer does not Account for its Modulation of Voltage-Gated Potassium Channels (2017) (0)
- Acknowledgment to reviewers 2017 (2017) (0)
- Voltage-gated potassium channels in larval CNS neurons of Drosophila. J Neurosci 8:2556-2570 (1988) (0)
- Faculty Opinions recommendation of Opening the KcsA K+ channel: tryptophan scanning and complementation analysis lead to mutants with altered gating. (2002) (0)
- Temperature-Dependent Heat Capacity (ΔC(T)) Modification of the Thermodynamic Framework for Thermotrp Channels Eliminates Predicted Dual Thermosensitivity (2019) (0)
- Calcium Dependent Stoichiometries of an SK2 Intracellular Domain/Calmodulin Complex (2014) (0)
- Erratum: (Journal of General Physiology (September 2002) 120:3 (267-305)) (2002) (0)
- Using neurotoxins to understand the role of BK Channels in the brain (2007) (0)
- Editor's evaluation: Tracking the movement of discrete gating charges in a voltage-gated potassium channel (2020) (0)
- Both Lobes of Calmodulin Bound to KCa2.2 Respond to Ca2+ (2020) (0)
- Unexpected Patterns and Complexity Profiling the Phospho-status of the BKCa Channel {alpha} Subunit in Rat Brain Reveals (2009) (0)
- Ion Interactions and C-Type Inactivation The recent determination of the crystal structure of a prokaryotic potassium channel from Streptomyces (1999) (0)
- Charge Substitution of a Deep-Pore Residue Suggests Structural Rearrangements During BK Channel Activation (2010) (0)
- Local potassium signalling couples astrocytic activity to brain microvascular function (2007) (0)
- Inward Rectification by an Activation Gating Mechanism (1997) (0)
- Erratum: Restoration of Inactivation in Mutants Of Shaker Potassium Channels by a Peptide Derived from ShB (1991) (0)
- Amino Acid Contributions to Binding across Paired EF-Hands in Calmodulin (2017) (0)
- The Stoichiometry of an SK Channel Peptide and Calmodulin (2013) (0)
- Calcium dependence of both lobes of calmodulin is involved in SK channel gating (2022) (0)
- Correction (2002) (0)
- Calcium dependence of both lobes of calmodulin is involved in binding to a cytoplasmic domain of SK channels (2022) (0)
- Manon de Boer: Between Perception and Sensation (2011) (0)
- Improved Quantitative Modeling of Ligand-Activated Macromolecular Receptors using Conditional Binding (2013) (0)
- Single Aspartate Substitutions at Multiple Deep-Pore Positions Lead to Constitutively Open BK Channels (2013) (0)
- TRP channels in vascular endothelium: TRPV4 in focus (2007) (0)
- Microelectrode Techniques: The Plymouth Workshop Handbook edited by N. B. Standen, P. T. A. Gray and M. J. Whitaker, The Company of Biologists, 1987. £16.00/US$30.00 (ix + 256 pages) ISBN 0 948601 09 4 (1989) (0)
- Acknowledgment of Reviewers, 2018 (2018) (0)
- Ion-Dependent Binding-Site Configurations in Ef-Hand Proteins Measured with Ultrafast Infrared Spectroscopy (2019) (0)
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