William J. Rutter

William J. Rutter's AcademicInfluence.com Rankings

William J. Rutter

Biology

#329

World Rank

#596

Historical Rank

#192

USA Rank

Biochemistry

#46

World Rank

#60

Historical Rank

#31

USA Rank

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Biology

Why Is William J. Rutter Influential?

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According to Wikipedia, William J. Rutter is an American biochemist who cofounded the early biotechnology company Chiron Corporation together with Edward Penhoet and Pablo DT Valenzuela. As chairman of the department of biochemistry and biophysics of the University of California, San Francisco, Rutter helped establish that department as a leader in the academic side of the biotechnology during the San Francisco Bay Area biotech boom of the 1980s.

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William J. Rutter's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. (1979) (19276)
The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling (1985) (1224)
Rat insulin genes: construction of plasmids containing the coding sequences. (1977) (1026)
Polymorphic DNA region adjacent to the 5' end of the human insulin gene. (1981) (867)
Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose (1986) (862)
Multiple Forms of DNA-dependent RNA Polymerase in Eukaryotic Organisms (1969) (840)
Synthesis and assembly of hepatitis B virus surface antigen particles in yeast (1982) (797)
Insulin-like growth factor II receptor as a multifunctional binding protein (1987) (788)
Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin (1970) (739)
Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin (1985) (544)
An ultrastructural analysis of the developing embryonic pancreas. (1972) (526)
The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences (1982) (497)
Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes (1983) (493)
Sequence of the human insulin gene (1980) (478)
Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elements. (1985) (475)
Converting trypsin to chymotrypsin: the role of surface loops. (1992) (442)
Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor (1983) (437)
Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation (1990) (428)
The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription (1995) (391)
Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins. (1983) (391)
Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. (1992) (388)
Isolation of full-length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning. (1987) (384)
Specific nucleolar and nucleoplasmic RNA polymerases. (1970) (378)
Toward molecular mechanisms of developmental processes. (1973) (350)
Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen. (1986) (337)
Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. (1995) (330)
Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos. (1992) (319)
The neural crest and the origin of the insulin-producing and other gastrointestinal hormone-producing cells. (1976) (315)
Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors. (1996) (311)
Nucleotide and corresponding amino acid sequences encoded by α and β tubulin mRNAs (1981) (307)
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity. (1987) (300)
Redesigning trypsin: alteration of substrate specificity. (1985) (299)
THE NUCLEOTIDE SEQUENCE OF THE HEPATITIS B VIRAL GENOME AND THE IDENTIFICATION OF THE MAJOR VIRAL GENES (1980) (290)
Expression and characterization of a functional human insulin-like growth factor I receptor. (1988) (281)
Distribution of fructose diphosphate aldolase variants in biological systems. (1969) (279)
Integration of hepatitis B virus sequences and their expression in a human hepatoma cell (1980) (277)
Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish (1980) (274)
Pancreatic islet-acinar cell interaction: amylase messenger RNA levels ar determined by insulin. (1981) (266)
The catalytic role of the active site aspartic acid in serine proteases. (1987) (255)
A human hepatitis B viral enhancer element. (1985) (250)
Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen (1979) (243)
Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. (1980) (241)
Human somatostatin I: sequence of the cDNA. (1982) (241)
Multiple forms of fructose diphosphate aldolase in mammalian tissues. (1966) (235)
Homology requirements for recombination in Escherichia coli. (1985) (234)
Onset of cell-specific gene expression in the developing mouse pancreas. (1992) (224)
Splice junctions: association with variation in protein structure. (1983) (215)
Tubulin genes are tandemly linked and clustered in the genome of trypanosoma brucei (1983) (211)
EVOLUTION OF ALDOLASE. (1964) (205)
Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm (1988) (205)
A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer. (1987) (205)
COMPARATIVE STUDIES OF LIVER AND MUSCLE ALDOLASE. II. IMMUNOCHEMICAL AND CHROMATOGRAPHIC DIFFERENTIATION. (1963) (193)
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. (1988) (189)
Isolation and characterization of a cloned rat insulin gene (1979) (187)
Structure and Regulatory Properties of Eucaryotic RNA Polymerase (1970) (186)
Regulation of specific protein synthesis in cytodifferentiation (1968) (185)
The Insulin Gene Promoter: A Simplified Nomenclature (1995) (174)
Multiple ribonucleic acid polymerases and ribonucleic acid synthesis during sea urchin development. (1970) (173)
The subunit structure of mammalian fructose diphosphate aldolase. (1967) (171)
Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA. (1985) (168)
The prolactin gene is located on chromosome 6 in humans. (1981) (166)
Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs. (1990) (165)
Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases. (1993) (164)
Structure of yeast phenylalanine-tRNA genes: an intervening DNA segment within the region coding for the tRNA. (1978) (164)
The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes (1992) (163)
Pancreatic beta cells express a diverse set of homeobox genes. (1994) (162)
Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures. (1990) (162)
Directed expression of NGF to pancreatic β cells in transgenic mice leads to selective hyperinnervation of the islets (1989) (159)
A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain. (1993) (156)
A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes. (1988) (153)
Ribosomal RNA genes of Saccharomyces cerevisiae. I. Physical map of the repeating unit and location of the regions coding for 5 S, 5.8 S, 18 S, and 25 S ribosomal RNAs. (1977) (149)
Genes for growth hormone, chorionic somatommammotropin, and growth hormones-like gene on chromosome 17 in humans. (1980) (149)
Ioslation of fructose diphosphate aldolases A, B, and C. (1969) (143)
Molecular and catalytic properties of aldolase C. (1969) (143)
Electrostatic complementarity within the substrate-binding pocket of trypsin. (1988) (143)
Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin. (1987) (140)
Sequence of the human somatostatin I gene. (1984) (140)
Hepatitis B viral DNA in liver and serum of asymptomatic carriers. (1982) (139)
Synthesis of hepatitis B surface and core antigens in E. coli (1981) (138)
Climate change and the integrity of science. (2010) (137)
Regulation of secretion of the hepatitis B virus major surface antigen by the preS-1 protein (1987) (134)
Mouse nerve growth factor gene: structure and expression (1987) (133)
Structural origins of substrate discrimination in trypsin and chymotrypsin. (1995) (132)
Processing of the native nerve growth factor precursor to form biologically active nerve growth factor. (1988) (130)
Nucleotide sequence of a cDNA clone encoding human preproinsulin (1979) (130)
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin. (1970) (129)
Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind the insulin enhancer. (1991) (129)
Some distinctive properties of pyruvate kinase purified from rat liver. (1968) (128)
Converting trypsin to chymotrypsin: residue 172 is a substrate specificity determinant. (1994) (128)
THE DEVELOPMENT OF THE DORSAL AND VENTRAL MAMMALIAN PANCREAS IN VIVO AND IN VITRO (1970) (128)
Structure of two related rat pancreatic trypsin genes. (1984) (126)
Structure of a family of rat amylase genes (1980) (125)
Differential RNA splicing predicts two distinct nerve growth factor precursors (1986) (123)
The molecular characteristics of yeast aldolase. (1969) (123)
Isolation of a transcriptionally active chromosome from chloroplasts of Euglena gracilis. (1976) (122)
Nerve growth factor induces the proto-oncogene c-jun in PC12 cells. (1989) (119)
Pur-1, a zinc-finger protein that binds to purine-rich sequences, transactivates an insulin promoter in heterologous cells. (1992) (117)
Regulation of rat insulin 1 gene expression: evidence for negative regulation in nonpancreatic cells. (1986) (116)
Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11. (1995) (116)
Preparation and properties of yeast aldolase. (1961) (114)
Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ. (2000) (114)
Hepatitis B virus (HBV) promoters are regulated by the HBV enhancer in a tissue-specific manner (1989) (112)
Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector (1988) (111)
Expression of a functional human insulin receptor from a cloned cDNA in Chinese hamster ovary cells. (1985) (111)
Method for the detection of pyruvate kinase, aldolase, and other pyridine nucleotide linked enzyme activities after electrophoresis. (1971) (109)
The insulin gene is located on chromosome 11 in humans (1980) (109)
Analysis of the regions flanking the human insulin gene and sequence of an Alu family member. (1980) (107)
Transcription of hepatitis B virus by RNA polymerase II (1983) (106)
Sequence of hepatitis B virus DNA incorporated into the genome of a human hepatoma cell line (1985) (105)
Leukocyte and fibroblast interferon genes are located on human chromosome 9. (1981) (104)
Heterogeneity of Presumably Homogeneous Protein Preparations (1969) (103)
Structure and processing of yeast precursor tRNAs containing intervening sequences (1978) (102)
CONTROL OF SPECIFIC SYNTHESIS IN THE DEVELOPING PANCREAS. (1964) (101)
Intron–exon splice junctions map at protein surfaces (1982) (100)
Cell-specific enhancers in the rat exocrine pancreas. (1986) (100)
Purification and properties of pigeon liver malic enzyme. (1958) (99)
Arginine 127 stabilizes the transition state in carboxypeptidase. (1990) (99)
Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity (1997) (99)
Isolation and sequence of a rat chymotrypsin B gene. (1984) (99)
Primary structure of two distinct rat pancreatic preproelastases determined by sequence analysis of the complete cloned messenger ribonucleic acid sequences. (1982) (96)
ALDOLASE VARIANTS: STRUCTURE AND PHYSIOLOGICAL SIGNIFICANCE * (1968) (94)
Catalytic and immunochemical properties of homomeric and heteromeric combinations of aldolase subunits. (1971) (93)
The effect of oxygen tension on the growth and metabolism of a mammalian cell. (1961) (92)
The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity. Evidence from receptor chimeras. (1990) (91)
Synthesis of hepatitis B surface antigen in mammalian cells: expression of the entire gene and the coding region (1983) (91)
Reversible dissociation of aldolase into unfolded subunits. (1963) (91)
Site-directed mutagenesis shows that tyrosine 248 of carboxypeptidase A does not play a crucial role in catalysis (1985) (91)
Assembly of viral particles in Xenopus oocytes: pre-surface-antigens regulate secretion of the hepatitis B viral surface envelope particle. (1986) (90)
Role of the S' subsites in serine protease catalysis. Active-site mapping of rat chymotrypsin, rat trypsin, alpha-lytic protease, and cercarial protease from Schistosoma mansoni. (1994) (90)
A murine fer testis-specific transcript (ferT) encodes a truncated Fer protein (1990) (90)
The Insulin Gene Is Located on the Short Arm of Chromosome 11 in Humans (1981) (87)
Systematic binding analysis of the insulin gene transcription control region: insulin and immunoglobulin enhancers utilize similar transactivators (1988) (87)
Structure of the two related elastase genes expressed in the rat pancreas. (1984) (87)
A novel rat carboxypeptidase, CPA2: characterization, molecular cloning, and evolutionary implications on substrate specificity in the carboxypeptidase gene family. (1988) (84)
Early differentiation of glucagon-producing cells in embryonic pancreas: a possible developmental role for glucagon. (1973) (84)
Comparative studies of liver and muscle aldolase. I. Effect of carboxypeptidase on catalytic activity. (1961) (84)
Effects of a partially purified factor from chick embryos on macromolecular synthesis of embryonic pancreatic epithelia. (1973) (84)
Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region (1984) (81)
Individual protein-binding domains of the insulin gene enhancer positively activate beta-cell-specific transcription (1989) (77)
Selective expression of rat pancreatic genes during embryonic development. (1986) (77)
A functional role of metal ions in a class II aldolase. (1969) (76)
Control of cell proliferation and cytodifferentiation by a factor reacting with the cell surface. (1973) (76)
Molecular structures of DNA-dependent RNA polymerases (II) from calf thymus and rat liver. (1971) (75)
Increased thermal stability of chromatin containing 5-bromodeoxyuridine-substituted DNA. (1974) (75)
The developmental regulation of amylolytic and proteolytic enzymes in the embryonic rat pancreas. (1974) (74)
Mapping the S' subsites of serine proteases using acyl transfer to mixtures of peptide nucleophiles. (1993) (74)
Glucocorticoids modulate the in vitro development of the embryonic rat pancreas (1977) (73)
A membrane-anchored cytoplasmic domain of the human insulin receptor mediates a constitutively elevated insulin-independent uptake of 2-deoxyglucose. (1987) (70)
Comparative properties of yeast and muscle aldolase. (1961) (70)
Expression of the human insulin gene and cDNA in a heterologous mammalian system. (1983) (69)
On the mechanism of 5-bromodeoxyuridine inhibition of exocrine pancreas differentiation. (1974) (68)
Changes in the frequency of specific transcripts during development of the pancreas. (1977) (67)
The insulinomimetic agents H2O2 and vanadate stimulate tyrosine phosphorylation of potential target proteins for the insulin receptor kinase in intact cells. (1992) (67)
Hybrid hepatitis B virus-host transcripts in a human hepatoma cell. (1985) (66)
Structural characterization of the rat carboxypeptidase A1 and B genes. Comparative analysis of the rat carboxypeptidase gene family. (1988) (66)
Are all nucleotidyl transferases metalloenzymes? (1973) (66)
Cloning and analysis of integrated hepatitis virus sequences from a human hepatoma cell line (1984) (65)
Molecular structure of yeast RNA polymerase III: demonstration of the tripartite transcriptive system in lower eukaryotes. (1976) (65)
Insulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophosphorylation. (1992) (64)
Glyceraldehyde-3-Phosphate Dehydrogenase Variants in Phyletically Diverse Organisms (1967) (63)
Converting trypsin to chymotrypsin: ground-state binding does not determine substrate specificity. (1994) (62)
Molecular properties of rat pancreatic and parotid -amylase. (1972) (62)
LIVER AMYLASE. III. SYNTHESIS BY THE PERFUSED LIVER AND SECRETION INTO THE PERFUSION MEDIUM. (1963) (61)
[87] Fructose diphosphate aldolase (1966) (61)
Cloning of a Drosophila cDNA encoding a polypeptide similar to the human insulin receptor precursor. (1986) (61)
An analysis of pancreatic development: role of mesenchymal factor and other extracellular factors. (1978) (59)
Phases in cell differentiation. (1969) (59)
Phosphorylation of yeast DNA-dependent RNA polymerases in vivo and in vitro. Isolation of enzymes and identification of phosphorylated subunits. (1977) (57)
Multiple molecular forms of alpha-amylase from the rabbit. (1969) (56)
Magnetic resonance studies of the role of the divalent cation in the mechanism of yeast aldolase. (1971) (55)
Ribosomal RNA genes of Saccharomyces cerevisiae. II. Physical map and nucleotide sequence of the 5 S ribosomal RNA gene and adjacent intergenic regions. (1977) (55)
Rat preprocarboxypeptidase A: cDNA sequence and preliminary characterization of the gene. (1982) (54)
The metabolism of lactose and galactose in the chick. (1953) (53)
Expression and characterization of a functional human insulin like growth factor-I receptor. J Biol Chem 263:11486-11492 (1988) (53)
Synthesis and accumulation of insulin in the fetal rat pancreas. (1972) (53)
The biosynthesis and processing of proteins in the mouse 7S nerve growth factor complex. (1983) (51)
Nucleotide sequence of the yeast 5S ribosomal RNA gene and adjacent putative control regions (1977) (51)
Rat insulin genes: construction of plasmids containing the coding sequences. 1977. (1992) (51)
A class I (Schiff base) fructose diphosphate aldolase of prokaryotic origin. Purification and properties of Micrococcus aerogenes aldolase. (1973) (50)
Proteins synthesized and secreted during rat pancreatic development (1980) (50)
ENZYME VARIANTS AND METABOLIC DIVERSIFICATION. (1963) (49)
Insulin and insulin-like growth factor receptors and responses. (1988) (49)
Attempts to convert chymotrypsin to trypsin (1996) (48)
Integration of hepatitis B virus DNA in chromosome-specific satellite sequences (1986) (47)
Polymorphic human somatostatin gene is located on chromosome 3. (1983) (47)
Meso1, a basic-helix-loop-helix protein involved in mammalian presomitic mesoderm development. (1995) (46)
Transition-state characterization: a new approach combining inhibitor analogues and variation in enzyme structure. (1992) (46)
Phosphorylation of yeast RNA polymerases (1976) (46)
The proopiocortin (adrenocorticotropin/β-lipotropin) gene is located on chromosome 2 in humans (1981) (46)
Cobra nerve growth factor: Structure and evolutionary comparison (1987) (45)
Selective interaction of 5'-bromodeoxyuridine substituted DNA with different chromosomal proteins. (1976) (45)
Liver Amylase I. CELLULAR DISTRIBUTION AND PROPERTIES (1961) (45)
Multiple pancreatic lipases. Tissue distribution and pattern of accumulation during embryological development. (1972) (45)
Galactosyltransferase activities in pancreas, liver and gut of the developing rat. (1973) (45)
Comparison of the nucleic acid sequence of anglerfish and mammalian insulin mRNA's from cloned cDNA's. (1980) (44)
Accumulation of the predominant pancreatic mRNAs during embryonic development. (1979) (43)
Positively charged side chains in the insulin-like growth factor-1 C- and D-regions determine receptor binding specificity. (1994) (43)
Activation of transforming potential of the human insulin receptor gene. (1987) (42)
Effects of dexamethasone and 5-bromodeoxyuridine on the synthesis of amylase mRNA during pancreatic development in vitro. (1978) (41)
The Interaction of Riboflavin, FMN, and FAD with Various Metal Ions: The Riboflavin Catalyzed Photochemical Reduction of FeIII, and Photooxidation of FeII. (1958) (41)
Positive control of cyclic AMP on mesenchymal factor controlled DNA synthesis in embryonic pancreas (1975) (40)
Enymic Homology. Structural and Catalytic Differentiation of Fructose Diphosphate Aldolase. (1963) (40)
Isolation of ribonucleic acid polymerases I, II, and III from Saccharomyces cerevisiae. (1977) (39)
Protein synthesis during the secondary developmental transition of the embryonic rat pancreas. (1972) (39)
Yeast DNA-dependent RNA polymerase I. A rapid procedure for the large scale purification of homogeneous enzyme. (1976) (39)
Evidence against a crucial role for the phenolic hydroxyl of Tyr-248 in peptide and ester hydrolyses catalyzed by carboxypeptidase A: comparative studies of the pH dependencies of the native and Phe-248-mutant forms (1986) (38)
Enhancement of transforming potential of human insulinlike growth factor 1 receptor by N-terminal truncation and fusion to avian sarcoma virus UR2 gag sequence (1992) (38)
Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser. (1994) (37)
The development of the endocrine and exocrine pancreas. (1980) (37)
Liver amylase. II. Physiological role. (1961) (37)
Transcription of yeast DNA by homologous RNA polymerases I and II: selective transcription of ribosomal genes by RNA polymerase I. (1977) (36)
Analysis of enzyme specificity by multiple substrate kinetics. (1993) (36)
5-bromodeoxyuridine may alter the differentiative program of the embryonic pancreas (1976) (35)
Modulating effects of the extracellular sequence of the human insulinlike growth factor I receptor on its transforming and tumorigenic potential (1993) (35)
Properties of the insulin receptor ectodomain. (1988) (33)
Nucleotide sequence analysis of a proline-rich protein cDNA and peptide homologies of rat and human proline-rich proteins. (1984) (33)
Isolation and in vitro translation of the messenger RNA coding for pancreatic amylase. (1977) (33)
Characterization of purified poly(adenylic acid)-containing messenger ribonucleic acid from Saccharomyces cerevisiae. (1977) (33)
Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells. (1987) (33)
Structural evolution of an enzyme specificity. The structure of rat carboxypeptidase A2 at 1.9-A resolution. (1991) (33)
Heterologous transmembrane signaling by a human insulin receptor-v-ros hybrid in Chinese hamster ovary cells. (1987) (32)
Rat pancreatic amylase mRNA. Tissue specificity and accumulation during embryonic development. (1978) (32)
The mechanism of action of fructose diphosphate aldolase. (1958) (31)
A nephelometric method for the determination of glycogen. (1952) (31)
Glucose production by isolated rat liver cells. An amylase-oligoglucosidase pathway for glycogen breakdown. (1961) (31)
Yeast tRNA3Leu gene transcribed and spliced in a HeLa cell extract. (1981) (31)
A discordant sibship analysis between beta-NGF and neurofibromatosis. (1985) (31)
Reversible alteration of the structure of enzymes in acidic solution. (1963) (30)
The chymotrypsin enhancer core. Specific factor binding and biological activity. (1989) (29)
Role of the prodomain in folding and secretion of rat pancreatic carboxypeptidase A1. (1996) (29)
Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs. (1981) (28)
The similarity of the glyceraldehyde 3-phosphate dehydrogenases isolated from rabbit brain and muscle. (1968) (28)
Yeast DNA dependent RNA polymerases I, II and III. The existence of subunits common to the three enzymes. (1976) (28)
A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain. (1993) (28)
Synthesis and accumulation of proinsulin and insulin during development of the embryonic rat pancreas. (1979) (28)
Mapping polypeptide hormone genes in the mouse: somatostatin, glucagon, calcitonin, and parathyroid hormone. (1987) (27)
Guanidine derivatives restore activity to carboxypeptidase lacking arginine‐127 (1992) (27)
Molecular control of proliferation and differentiation (1978) (26)
Selective regulation of trypsin gene expression by calcium and by glucose starvation in a rat exocrine pancreas cell line. (1986) (26)
The metabolism of bile acids in the developing rat liver. (1968) (26)
Detection and isolation of mammalian fructose-diphosphate aldolases. (1975) (25)
Isolation of yeast tRNALeu genes. DNA sequence of a cloned tRNALeu3 gene. (1979) (25)
Nucleotide polymerases in the developing avian erythrocyte. (1977) (24)
Specific gene transcription in yeast nuclei and chromatin by added homologous RNA polymerases I and II. (1979) (24)
Tissue and species differences in bile salt-dependent neutral cholesteryl ester hydrolase activity and gene expression. (1992) (24)
Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse (1984) (24)
STRUCTURE DETERMINATIONS OF FDP ALDOLASE AND THE FINE RESOLUTION OF SOME GLYCOLYTIC ENZYMES BY ISOELECTRIC FOCUSING (1973) (24)
The class I (Schiff base) fructose-diphosphate aldolase of Peptococcus aerogenes. (1975) (22)
Nucleic acid polymerizing enzymes in developing Strongylocentrotus franciscanus embryos. (1976) (22)
INFLUENCE OF INSULIN AND ENVIRONMENTAL FACTORS ON GLUCOSE UPTAKE IN EPIDIDYMAL FAT TISSUE. (1964) (22)
Enzymatic Homology and Analogy in Phylogeny (1965) (22)
Isolation of chicken hemoglobin mRNA and synthesis of complementary DNA. (1977) (22)
Lactose metabolism. II. The conversion of galactose to glucose derivatives in Lactobacillus bulgaricus strain Gere A. (1953) (22)
Control of insulin secretion in the developing pancreatic rudiment. (1975) (22)
Purification of rat liver and mouse ascites DNA-dependent RNA polymerase I. (1977) (21)
Use of directed mutagenesis to probe the role of tyrosine 198 in the catalytic mechanism of carboxypeptidase A. (1987) (21)
Interaction of Pyridine-Nucleotide linked Enzymes. (1956) (21)
Molecular basis of the activation of the tumorigenic potential of Gag-insulin receptor chimeras. (1991) (20)
Expression of the human insulin gene in an alternate mammalian cell and in cell extracts. (1983) (20)
A complementary DNA sequence that predicts a human pancreatic amylase primary structure consistent with the electrophoretic mobility of the common isozyme, Amy2 A. (1984) (20)
Expression of rat chymotrypsinogen in yeast: a study on the structural and functional significance of the chymotrypsinogen propeptide (1996) (20)
A protein cofactor that stimulates the activity of DNA-dependent RNA polymerase I on double-stranded DNA. (1977) (19)
Homologous recombination between a defective virus and a chromosomal sequence in mammalian cells. (1985) (19)
Hepatitis B virus encodes an RNA polymerase III transcript (1983) (19)
Transcription and in vitro processing of yeast 5 S rRNA. (1980) (18)
Effects of dexamethasone and 5-bromodeoxyuridine on protein synthesis and secretion during in vitro pancreatic development. (1983) (18)
λgt22, an improved λ vector for the directional cloning of full-length cDNA (1987) (18)
Linking functional domains of the human insulin receptor with the bacterial aspartate receptor. (1986) (18)
Mechanisms of receptor-mediated transmembrane communication. (1986) (18)
Fructose-diphosphate aldolase, pyruvate kinase, and pyridine nucleotide-linked activities after electrophoresis. (1975) (17)
A pancreatic exocrine cell factor and AP4 bind overlapping sites in the amylase 2A enhancer. (1991) (17)
The Effect of Ions on the Catalytic Activity of Enzymes: Yeast Glucose-6-phosphate Dehydrogenase. (1957) (16)
Regional mapping of the human placental alkaline phosphatase gene (ALPP) to 2q37 by in situ hybridization. (1988) (16)
Structural comparisons between the class I fructose diphosphate aldolases from Micrococcus aerogenes and rabbit. (1973) (16)
Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase (1984) (16)
Initiation of gastrin expression during the development of the mouse pancreas. (1992) (16)
Human skin mast cell carboxypeptidase: functional characterization, cDNA cloning, and genealogy. (1992) (16)
Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants. (1988) (14)
The DNase activities of the mouse. (1971) (14)
CONTROL OF DNA SYNTHESIS IN THE EMBRYONIC PANCREAS: INTERACTION OF THE MESENCHYMAL FACTOR AND CYCLIC AMP (1975) (14)
Role of metals in the class II aldolases. Spectral studies of cobalt yeast aldolase. (1971) (14)
The Molecular Basis of the Mesenchymal-Epithelial Interactions in Pancreatic Development (1977) (14)
Isolation of Intact mRNA and Construction of Full-Length cDNA Libraries: Use of a New Vector, λgt22, and Primer-Adapters for Directional cDNA Cloning (1988) (13)
The 24,000 dalton subunit and the activity of yeast RNA polymerases. (1976) (13)
Eukaryotic promoters drive gene expression in Escherichia coli. (1989) (13)
The effect of previous diet on the metabolism of glucose by rat diaphragm. (1951) (13)
Exocrine pancreas transcription factor 1 binds to a bipartite enhancer element and activates transcription of acinar genes (1991) (13)
Redesigning trypsin via genetic engineering (1987) (12)
A rapid and effective procedure for screening protease mutants. (1996) (12)
Independent regulation of cytochromes and glycolytic enzymes in human fibroblasts (1972) (12)
Association and phosphorylation-dependent dissociation of proteins in the insulin receptor complex. (1993) (12)
The molecular analysis of hepatitis B virus. (1986) (12)
Induction of tyrosine aminotransferase by triamcinolone during rat liver development in vitro. (1973) (12)
The mechanism of action of aldolases X. The combining sites of rabbit liver aldolase (1965) (11)
Fatty acid metabolism of rat diaphragm. (1952) (10)
Isolation and assay of eukaryotic DNA-dependent RNA polymerases. (1978) (10)
Endogenous substrates of the insulin receptor: studies with cells expressing wild-type and mutant receptors. (1991) (9)
Pancreas‐specific genes: Structure and expression (1981) (9)
Isolation and characterization of a rat amylase gene family. (1983) (9)
Synthesis of hepatitis B surface and core antigens in E. coli. 1981. (1992) (8)
Lambda gt22S, a phage expression vector for the directional cloning of cDNA by the use of a single restriction enzyme SfiI. (1988) (8)
RNA Polymerases and Transcriptive Specificity in Saccharomyces cerevisiae (1976) (8)
The proopiocortin (adrenocorticotropin/beta-lipoprotein) gene is located on chromosome 2 in humans. (1981) (8)
Insulin receptor and altered glucose transport in a monensin‐resistant mutant of Chinese hamster ovary cell (1989) (8)
Use of vaccinia virus vectors to study protein processing in human disease. Normal nerve growth factor processing and secretion in cultured fibroblasts from patients with familial dysautonomia. (1988) (8)
On the mechanism of variation of pancreatic amylase levels in mouse strains. (1981) (8)
Antibody-induced down-regulation of a mutated insulin receptor lacking an intact cytoplasmic domain. (1987) (7)
Molecular mechanisms in the control of gene expression : [proceedings] (1977) (7)
BIOASSAYS OF CYSTIC-FIBROSIS FACTOR (1974) (7)
Modulation of enzyme specificity by site-directed mutagenesis. (1991) (7)
Structural and functional integrity of specificity and catalytic sites of trypsin. (2009) (7)
Comparative Studies of Liver and Muscle Aldolase (2003) (6)
Cell communication in embryological development: the role of distal and proximal signals. (1978) (6)
Replacement of the human insulin receptor transmembrane and cytoplasmic domains by corresponding domains of the oncogene product v-ros leads to accelerated internalization, degradation, and down-regulation. (1990) (6)
Capturing nuclear sequence-specific DNA-binding proteins by using simian virus 40-derived minichromosomes (1988) (6)
Convenient vectors for cloning and sequencing EcoRI and HindIII fragments. (1987) (6)
A HUMAN HEPATOMA CELL LINE CONTAINS HEPATITIS B DNA AND RNA SEQUENCES (1980) (6)
Attempts to convert chymotrypsin to trypsin. (1996) (6)
Insulin receptor overexpression in a human pre-B acute lymphocytic leukemia cell line with a t(1;19) chromosome translocation near the INSR locus. (1989) (6)
Characterization of a cDNA encoding the insulin gene GAGA-binding factor, Pur-I. (1993) (6)
RNA Polymerases and Transcriptive Specificity in Eukaryotic Organisms (1973) (5)
clean grazing system for sheep--its development and extension (1984) (5)
A mammalian viral enhancer confers transcriptional regulation in yeast. (1988) (5)
The Effect of Ions on the Catalytic Activity of Enzymes: The Old Yellow Enzyme. (1957) (5)
Metabolic control mechanisms in animal cells : Symposium sponsored by Tissue Culture Association and National Cancer Institute, National Institutes of Health, Bethesda, Maryland, held May 28-30, 1963, Boston, Massachusetts (1964) (5)
Lambda gt22, an improved lambda vector for the directional cloning of full-length cDNA. (1987) (3)
IEG's: Some Evaluations. (1966) (3)
Assignment of the gene for carboxypeptidase A to human chromosome 7q22→qter and to mouse chromosome 6 (2004) (3)
Properties of a polymorphic DNA segment in the 5' flanking region of the human insulin gene. (1982) (3)
STRUCTURE OF PRECURSORS DERIVED FROM THE SEQUENCES OF CLONED cDNAs (1983) (2)
THE RELATIONSHIP OF GENE STRUCTURE TO PROTEIN STRUCTURE (1982) (2)
Purification of E. coli-synthesized Pan proteins and development of a Pan-specific monoclonal antibody. (1994) (2)
A Transcription Complex from Chloroplasts of Euglena Gracilis (1973) (2)
PANCREAS SPECIFIC GENES AND THEIR EXPRESSION DURING DIFFERENTIATION (1978) (2)
The human insulin receptor cDNA: a new tool to study the function of this receptor. (1987) (2)
Effects of Ions on the Activity of Enzyme Systems. (1955) (2)
Panel discussion: Present status and perspectives in the study of cytodifferentiation at the molecular level. II. Discussion (1968) (2)
Mapping polypeptide hormone genes in the mouse (1987) (2)
US immigration order strikes against biotech (2017) (2)
On the possible occurrence of DNA in mammalian reticulocytes. (1965) (2)
Isocitrate lyase. Kinetics and substrate-tritium exchange reactions. (1966) (2)
Transcriptional systems in eukaryotic cells. (1974) (2)
Erratum: Attempts to convert chymotrypsin to trypsin (FEBS Letters 379 (1996) (143-147)) (1996) (1)
CONTROL OF CELLULAR DIFFERENTIATION: OVERVIEW (1980) (1)
The malic enzymes (1964) (1)
THE STRUCTURE OF THE RIBOSOMAL RNA GENES OF THE YEAST SACCHAROMYCES CEREVISIAE (1978) (1)
Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants (1987) (1)
Homology requirements for recombination in Escherichia coli ( length dependence / insulin gene / synthetic oligonucleotides / supF miniplasmid (1)
ISOLATION AND NUCLEOTIDE SEQUENCE OF THE YEAST PHENYLALANINE-tRNA GENES: A NOVEL STRUCTURE INVOLVING AN INTERVENING DNA SEGMENT WITHIN THE CODING REGION (1978) (1)
The structure and expression of the insulin gene (1978) (1)
DNA transfer vector and recombinant microorganism containing a gene from a higher organism (1978) (0)
Takeover Bid: Chiron's Discussions with the Media. (1990) (0)
tumorigenic potential . factor I receptor on its transforming and sequence of the human insulinlike growth Modulating effects of the extracellular (0)
Howard Goodman and William Rutter Letter (1995) (0)
A recombinant DNA transfer vector (1991) (0)
PRODUCTION OF “VALUABLE” PROTEINS IN ALTERNATE BIOLOGICAL HOSTS (1979) (0)
The earliest transcriptional events in pancreatic organogenesis (1993) (0)
Structure of the Inner Bristol Channel and Severn Estuary borderlands, UK: regional mapping and seismic interpretation yield a refined model for mountain front deformation and inversion. (2021) (0)
A Class P ( S & E Base ) Fructose Diphosphate Aldolase of Prokaryotic Origin (2002) (0)
LACTOSE METABOLISM. 2. THE CONVERSION OF GALACTOSE TO GLUCOSE DERIVATIVES IN L. BULGARICUS STRAIN GERE A (1953) (0)
[Cloning and expression of human insulin receptors]. (1986) (0)
Patents And literature (1985) (0)
Independently Regulated Synthetic Transitions in Foetal Tissues (2008) (0)
Immunoassay reagent and method for detecting hepatitis antibodies C virus (HCV) (2002) (0)
Sequence ofHepatitis B VirusDNA Incorporated intotheGenome ofaHumanHepatoma CellLine (1985) (0)
Chinese scientists and US leadership in the life sciences (2019) (0)
Methods for preparing and selecting peptides having specific properties (1989) (0)
Introduction to Enzymology. (1959) (0)
Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoptastk cells (2005) (0)
Mono clonal antibodies directed against rat pancreas membranes (1981) (0)
Polypeptides of the hepatitis C virus (HIV) (1992) (0)
THE INSULIN (IGF) GENE FAMILY (1983) (0)
Author Correction: Supporting US public health experts (2020) (0)
Some Aspects of Lactose Metabolism (1952) (0)
Vaccine against virus NP procedure and means for the manufacture thereof (1980) (0)
Structure of yeast phenylalanine-t: segment within the region coding f, (2016) (0)
Supporting US public health experts (2020) (0)
Foerfarande Foer framstaellning of a recombinant DNA-molecule to som innehaoller I Foer tillvaexthormon the encoding nukleotidsekvens, and which have kan anvaendas at framstaellning of a tillvaexthormon producerande Mikroorganismen (1981) (0)
Systems and methods for determining the percentage of glycohemoglobin (2010) (0)
Polypeptides for Hepatitis C virus (HCV). (1992) (0)
DNA transfer vector for transformation of a microorganism (1978) (0)
Enkaroytiskt in synthesis of protein through anvaendning of the micro-organismer (1979) (0)
Dns-transfer vector, thus transformed host, vaccine and its production. (1980) (0)
Process for the preparation of an antibody against HBsAg (1991) (0)
Part A The Unfolding Genome (2012) (0)
Genes of human proinsulin and human pre-proinsulin, method of preparing them and their applications (1980) (0)
A refined method for studying the origins of the fetal pancreas in mice (1992) (0)
Dns-transfer-vector and a gen a higher organism containing microorganism (1978) (0)
Lactose metabolism. I. Carbohydrate metabolism of Lactobacillus bulgaricus strain Gere A. (1953) (0)
Control of transcription in eukaryotes: summary. (1981) (0)
The Isolation of a Green Pigment from Yeast. (1958) (0)
Yeast tRNA Precursors: Structure and Removal of Intervening Sequences by an Excision-Ligase Activity (1980) (0)
A process for preparing HBsAg, a DNA vector and a yeast cell containing the DNA vector for use in the method (1982) (0)
Corrections - Molecular and Catalytic Properties of Aldolase C (1970) (0)
LACTOSE METABOLISM. 1. CARBOHYDRATE METABOLISM OF L. BULGARICUS STRAIN GERE A (1952) (0)
MOLECULAR GENETICS AND INDIVIDUALITY (1984) (0)
Production of antigenic protein (1988) (0)

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