Victor Ambros
#8,883
Most Influential Person Now
American developmental biologist
Victor Ambros's AcademicInfluence.com Rankings
Victor Ambrosbiology Degrees
Biology
#266
World Rank
#477
Historical Rank
#155
USA Rank
Developmental Biology
#16
World Rank
#19
Historical Rank
#7
USA Rank
Molecular Biology
#106
World Rank
#109
Historical Rank
#64
USA Rank
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Biology
Victor Ambros's Degrees
- Bachelors Biochemistry Pennsylvania State University
Why Is Victor Ambros Influential?
(Suggest an Edit or Addition)According to Wikipedia, Victor R. Ambros is an American developmental biologist who discovered the first known microRNA . He is a professor at the University of Massachusetts Medical School in Worcester, Massachusetts. Background Ambros was born in New Hampshire. His father was a Polish war refugee and Victor grew up on a small dairy farm in Hartland, Vermont in a family of eight children, and went to school at Woodstock Union High School. He received his BS in Biology from the Massachusetts Institute of Technology in 1975 and completed his PhD in 1979 at the Massachusetts Institute of Technology, under the supervision of Nobel laureate David Baltimore. Ambros continued his research at MIT as the first postdoctoral fellow in the lab of future Nobel laureate H. Robert Horvitz. He became a faculty member at Harvard University in 1984 and moved to Dartmouth College in 1992. Ambros joined the faculty at the University of Massachusetts Medical School in 2008, and currently holds the title of Silverman Professor of Natural Sciences in the program in Molecular Medicine, endowed by his former Dartmouth student, Howard Scott Silverman.
Victor Ambros's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 (1993) (11915)
- The functions of animal microRNAs (2004) (10271)
- An Extensive Class of Small RNAs in Caenorhabditis elegans (2001) (3054)
- Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. (1991) (3053)
- A uniform system for microRNA annotation. (2003) (1825)
- Role of MicroRNAs in Plant and Animal Development (2003) (1764)
- microRNAs Tiny Regulators with Great Potential (2001) (1676)
- Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation (2004) (1550)
- The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. (1999) (1297)
- MicroRNA Pathways in Flies and Worms Growth, Death, Fat, Stress, and Timing (2003) (999)
- The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA (1997) (895)
- The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. (2000) (773)
- Heterochronic mutants of the nematode Caenorhabditis elegans. (1984) (771)
- MicroRNAs and Other Tiny Endogenous RNAs in C. elegans (2003) (739)
- Characterization of microRNA expression levels and their biological correlates in human cancer cell lines. (2007) (721)
- The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. (2005) (515)
- Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability (2007) (501)
- Potent effect of target structure on microRNA function (2007) (435)
- Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth. (2005) (420)
- A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans (1989) (368)
- Covalent linkage of a protein to a defined nucleotide sequence at the 5'-terminus of virion and replicative intermediate RNAs of poliovirus. (1977) (309)
- Encountering MicroRNAs in Cell Fate Signaling (2005) (306)
- Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity. (2003) (301)
- The regulation of genes and genomes by small RNAs (2007) (289)
- A new kind of informational suppression in the nematode Caenorhabditis elegans. (1989) (287)
- MicroRNAs and developmental timing. (2011) (266)
- A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity. (2008) (251)
- MicroRNA Pathways in Flies and Worms Growth, Death, Fat, Stress, and Timing (2003) (251)
- Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis. (2008) (226)
- Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity. (2008) (224)
- Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans. (1998) (220)
- mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein–enriched transcripts (2008) (217)
- Protein is linked to the 5' end of poliovirus RNA by a phosphodiester linkage to tyrosine. (1978) (215)
- Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans. (2006) (213)
- A short history of a short RNA (2004) (202)
- Identification of microRNAs and other tiny noncoding RNAs by cDNA cloning. (2004) (195)
- The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events. (1987) (194)
- nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans (2009) (190)
- The evolution of our thinking about microRNAs (2008) (174)
- Control of developmental timing in Caenorhabditis elegans. (2000) (165)
- Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis (2014) (164)
- The timing of lin-4 RNA accumulation controls the timing of postembryonic developmental events in Caenorhabditis elegans. (1999) (155)
- A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans (2009) (147)
- The expression of the let-7 small regulatory RNA is controlled by ecdysone during metamorphosis in Drosophila melanogaster. (2002) (146)
- The heterochronic gene lin-29 encodes a zinc finger protein that controls a terminal differentiation event in Caenorhabditis elegans. (1995) (143)
- Biodistribution and function of extracellular miRNA-155 in mice (2015) (125)
- Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi (2005) (120)
- Heterochronic Genes Control Cell Cycle Progress and Developmental Competence of C. elegans Vulva Precursor Cells (1996) (109)
- Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells. (1999) (109)
- Identification of a protein linked to nascent poliovirus RNA and to the polyuridylic acid of negative-strand RNA (1978) (107)
- Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. (1989) (106)
- An enzymatic activity in uninfected cells that cleaves the linkage between poliovirion RNA and the 5′ terminal protein (1978) (96)
- The Caenorhabditis elegans heterochronic gene pathway controls stage-specific transcription of collagen genes. (1995) (96)
- Developmental Decline in Neuronal Regeneration by the Progressive Change of Two Intrinsic Timers (2013) (87)
- Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress (2015) (79)
- Effect of life history on microRNA expression during C. elegans development. (2011) (73)
- Circulating Cell and Plasma microRNA Profiles Differ between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction (2013) (71)
- Heterochronic genes and the temporal control of C. elegans development. (1994) (68)
- The small RNA repertoire of Dictyostelium discoideum and its regulation by components of the RNAi pathway (2007) (64)
- The Caenorhabditis elegans Heterochronic Regulator LIN-14 Is a Novel Transcription Factor That Controls the Developmental Timing of Transcription from the Insulin/Insulin-Like Growth Factor Gene ins-33 by Direct DNA Binding (2005) (62)
- Heterochronic genes control the stage-specific initiation and expression of the dauer larva developmental program in Caenorhabditis elegans. (1989) (62)
- Reversal of cell fate determination in Caenorhabditis elegans vulval development. (1996) (60)
- Alternative temporal control systems for hypodermal cell differentiation in Caenorhabditis elegans (1991) (60)
- Purification and properties of a HeLa cell enzyme able to remove the 5'-terminal protein from poliovirus RNA. (1980) (59)
- The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans. (2008) (59)
- The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans. (2013) (58)
- Systematic analysis of dynamic miRNA-target interactions during C. elegans development (2009) (53)
- Circulating MicroRNAs in cardiovascular disease. (2011) (51)
- miR-14 regulates autophagy during developmental cell death by targeting ip3-kinase 2. (2014) (50)
- The Embryonic mir-35 Family of microRNAs Promotes Multiple Aspects of Fecundity in Caenorhabditis elegans (2014) (50)
- The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin (2004) (50)
- Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets (2009) (49)
- Dauer larva quiescence alters the circuitry of microRNA pathways regulating cell fate progression in C. elegans (2012) (49)
- Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides (2020) (48)
- A microRNA family exerts maternal control on sex determination in C. elegans (2016) (47)
- Structure and Function Analysis of LIN-14, a Temporal Regulator of Postembryonic Developmental Events in Caenorhabditis elegans (2000) (47)
- Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs (2018) (44)
- Robust Distal Tip Cell Pathfinding in the Face of Temperature Stress Is Ensured by Two Conserved microRNAS in Caenorhabditis elegans (2015) (33)
- Mutations in Conserved Residues of the C. elegans microRNA Argonaute ALG-1 Identify Separable Functions in ALG-1 miRISC Loading and Target Repression (2014) (32)
- Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans (2015) (31)
- The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans (2019) (27)
- Dicing Up RNAs (2001) (26)
- Separation of quantitation of intracellular forms of poliovirus RNA by agarose gel electrophoresis (1977) (22)
- An efficient and sensitive method for preparing cDNA libraries from scarce biological samples (2014) (21)
- Pheromones and Nutritional Signals Regulate the Developmental Reliance on let-7 Family MicroRNAs in C. elegans (2019) (21)
- MicroRNAs: Genetically Sensitized Worms Reveal New Secrets (2010) (21)
- Molecular cloning of lin-29, a heterochronic gene required for the differentiation of hypodermal cells and the cessation of molting in C.elegans. (1991) (21)
- MicroRNAs: From Basic Science to Disease Biology (2009) (20)
- Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal (2015) (20)
- Comparison of RNA isolation and associated methods for extracellular RNA detection by high-throughput quantitative polymerase chain reaction. (2016) (18)
- Genetic Basis for Heterochronic Variation (1988) (18)
- Inhibiting miRNA in Caenorhabditis elegans using a potent and selective antisense reagent (2010) (17)
- Staufen Negatively Modulates MicroRNA Activity in Caenorhabditis elegans (2016) (17)
- Separation and quantitation of intracellular forms of poliovirus RNA by agarose gel electrophoresis. (1977) (12)
- The Developmental Timing Regulator hbl-1 Modulates the Dauer Formation Decision in Caenorhabditis elegans (2011) (12)
- The temporal control of cell cycle and cell fate in Caenorhabditis elegans. (2001) (11)
- Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity (2018) (11)
- Regulation of nuclear-cytoplasmic partitioning by the lin-28-lin-46 pathway reinforces microRNA repression of HBL-1 to confer robust cell-fate progression in C. elegans (2019) (10)
- Pseudomonas aeruginosa cleaves the decoding center of Caenorhabditis elegans ribosomes (2020) (8)
- Critical contribution of 3’ non-seed base pairing to the in vivo function of the evolutionarily conserved let-7a microRNA (2021) (6)
- The C. elegans heterochronic gene lin-28 coordinates the timing of hypodermal and somatic gonadal programs for hermaphrodite reproductive system morphogenesis (2018) (6)
- mirWIP: microRNA Target Prediction Based on miRNP Enriched Transcripts (2011) (5)
- miR-122 in mammalian liver (2007) (4)
- Engineering essential genes with a “jump board” strategy using CRISPR/Cas9 (2020) (4)
- Critical contribution of 3′ non-seed base pairing to the in vivo function of the evolutionarily conserved let-7a microRNA (2022) (4)
- RNA-seq with RNase H-based ribosomal RNA depletion specifically designed for C. elegans (2020) (3)
- A cohort of Caenorhabditis species lacking the highly conserved let-7 microRNA (2020) (3)
- Mathematics of microRNAs: stabilizing gene regulatory networks (2019) (3)
- C. elegans LIN-28 controls temporal cell-fate progression by regulating LIN-46 expression via the 5’UTR of lin-46 mRNA (2019) (3)
- Victor Ambros: the broad scope of microRNAs. Interview by Caitlin Sedwick. (2013) (3)
- Replicative Intermediate RNAs of Poliovirus Covalent Linkage of a Protein to a Defined Nucleotide Sequence at the 5'-Terminus of Virion and (2006) (3)
- Circulating microRNA Profiles in Acetaminophen Toxicity (2019) (3)
- Correction: Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity (doi: 10.1242/dev.172031) (2019) (2)
- Development: Keeping Time with Transcription (2021) (1)
- Abstract 249 (2003) (1)
- In the tradition of science: an interview with Victor Ambros. (2010) (1)
- The protein covalently linked to the 5' end of poliovirus RNA. (1979) (1)
- Characterization of microRNA expression and their biological correlates in the NCI-60 panel of human tumor derived cell lines (2006) (1)
- C. elegans LIN-28 controls temporal cell fate progression by regulating LIN-46 expression via the 5′ UTR of lin-46 mRNA (2021) (1)
- Abstract 249 (2003) (1)
- Decision letter: Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates (2020) (0)
- The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans (2019) (0)
- Circulating microRNAs are associated with Paroxysmal or Persistent Atrial Fibrillation (2012) (0)
- Environmental pheromone and endocrine signals correct heterochronic developmental phenotypes caused by insufficient expression of let-7 family microRNAs in C. elegans (2019) (0)
- MiRNAs in skeletal muscle differentiation (2007) (0)
- are abundant in human serum and plasma pseudogenes transcripts from specific YRNA genes and -YRNA fragments derived by processing of (2015) (0)
- Decision letter: Somatic aging pathways regulate reproductive plasticity in Caenorhabditis elegans (2020) (0)
- Commentary A Short History of a Short RNA (2004) (0)
- Reversal of vulval determination L 1 L 2 L 3 lin-28 WT lin-28 dauer arrest (1996) (0)
- Peculiarities of non coding micrornas organization in H. Sapiens and some other species (2018) (0)
- MicroRNAs: List of contributors (2007) (0)
- Modeling neurodevelopmental disorder-associated hAGO1 mutations in C. elegans Argonaute ALG-1 (2023) (0)
- Victor Ambros (1953-) (2020) (0)
- Abstract 15208: Circulating Cell and Plasma MicroRNA Profiles Differ Between Non-St-Segment and St-Segment-Elevation Myocardial Infarction (2013) (0)
- THE PROPRIETY ROLE OF CIRCULATING MICRORNAS IN PAROXYSMAL OR PERSISTENT ATRIAL FIBRILLATION (2013) (0)
- RNAi and epigenetic regulation of Dictyostelium retrotransposon (2005) (0)
- MicroRNAs: Foreword by Victor R. Ambros (2007) (0)
- MICRO RNA : PAST , PRESENT AND FUTURE (2012) (0)
- Foreword by Sidney Altman (2007) (0)
- Fluorescently labeled antisense reagents for inhibiting microRNA in C. elegans (2009) (0)
- Plasma microRNAs are Associated with Atrial Fibrillation (the miRhythm Study) and Change After Catheter-ablation (2014) (0)
- NpgRJ_NSMB_1226 287..294 (2019) (0)
- The 2007 George W. Beadle Medal (2007) (0)
- elegansembryonic expression of microRNA genes in The FLYWCH transcription factors FLH-1 , FLH-2 , and FLH-3 repress data (2008) (0)
- Franklin medal in life science is Presented to (2011) (0)
- Machine learning predicts microRNA target sites (2007) (0)
- RNA: Reviewers for Volume 21, 2015. (2015) (0)
- microRNA promoter activity Caenorhabditis elegans Genome-scale spatiotemporal analysis of Material Supplemental (2017) (0)
- pRB/CKI pathways at the interface of cell cycle and development (2009) (0)
- Craig C. Mello (1960 (2017) (0)
- Caenorhabditis elegans Heterochronic mutants of the nematode (2007) (0)
- MethodologymiRNA in Caenorhabditis elegans using a potent and selective antisense reagent (2010) (0)
- Circulating microRNA Profiles in Acetaminophen Toxicity (2019) (0)
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