Antonius Jozef Maria Berns
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Antonius Jozef Maria Bernsbiology Degrees
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Cell Biology
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Genetics
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Molecular Biology
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Biology
Antonius Jozef Maria Berns's Degrees
- PhD Molecular Biology University of Amsterdam
- Masters Biology University of Amsterdam
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(Suggest an Edit or Addition)Antonius Jozef Maria Berns's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs (1994) (2237)
- Simplified mammalian DNA isolation procedure. (1991) (1556)
- Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease (1993) (1383)
- Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. (2000) (783)
- Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region (1984) (618)
- Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. (1998) (591)
- Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. (1999) (483)
- Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules (1997) (474)
- Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs. (1992) (466)
- For better or for worse: the role of Pim oncogenes in tumorigenesis (2011) (440)
- In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes (1988) (372)
- Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. (2000) (354)
- p107 is a suppressor of retinoblastoma development in pRb-deficient mice. (1998) (335)
- The pim‐1 oncogene encodes two related protein‐serine/threonine kinases by alternative initiation at AUG and CUG. (1991) (297)
- Developmental rescue of an embryonic‐lethal mutation in the retinoblastoma gene in chimeric mice. (1994) (284)
- Retroviral insertional mutagenesis: past, present and future (2005) (283)
- Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex. (1997) (279)
- Cre-mediated somatic site-specific recombination in mice. (1997) (268)
- Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. (1999) (264)
- Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2 (1991) (263)
- Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells (1990) (243)
- Live attenuated pseudorabies virus expressing envelope glycoprotein E1 of hog cholera virus protects swine against both pseudorabies and hog cholera (1991) (224)
- Involvement of c‐myc in MuLV‐induced T cell lymphomas in mice: frequency and mechanisms of activation. (1984) (217)
- Retroviral insertional mutagenesis as a strategy to identify cancer genes. (1996) (210)
- Proviral activation of the putative oncogene Pim‐1 in MuLV induced T‐cell lymphomas. (1985) (207)
- Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. (2001) (201)
- Mice with a targeted disruption of the Fanconi anemia homolog Fanca. (2000) (198)
- Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene (2001) (194)
- The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases (1986) (189)
- Proviral tagging in E mu‐myc transgenic mice lacking the Pim‐1 proto‐oncogene leads to compensatory activation of Pim‐2. (1995) (187)
- Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally (1991) (187)
- Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice (1995) (182)
- Bax alpha perturbs T cell development and affects cell cycle entry of T cells. (1996) (182)
- Immunological defects in mice with a targeted disruption in Bcl-3. (1997) (173)
- Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc (1997) (169)
- Contribution of single genes within the unique short region of Aujeszky's disease virus (suid herpesvirus type 1) to virulence, pathogenesis and immunogenicity. (1992) (166)
- Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus (1981) (161)
- Transcription of T cell receptor beta‐chain genes is controlled by a downstream regulatory element. (1988) (157)
- Thymic lymphomas in interleukin 9 transgenic mice. (1994) (151)
- Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse (1998) (149)
- Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice (1989) (147)
- T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous α- and β-genes (1988) (144)
- Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein. (1999) (136)
- Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger (1997) (135)
- Marker vaccines, virus protein-specific antibody assays and the control of Aujeszky's disease. (1990) (127)
- In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes. (1988) (126)
- Characterization and chromosomal localization of the human proto-oncogene BMI-1. (1993) (120)
- In vivo analysis of Pim-1 deficiency. (1993) (119)
- Gene therapy for hemophilia A: production of therapeutic levels of human factor VIII in vivo in mice. (1995) (119)
- Conditional biallelic Nf 2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2 (2000) (118)
- T-cell receptor gamma delta and gamma transgenic mice suggest a role of a gamma gene silencer in the generation of alpha beta T cells. (1990) (114)
- Adenoviral heterogeneous nuclear RNA is associated with the host nuclear matrix during splicing. (1982) (114)
- Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling (2014) (112)
- Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice (1997) (110)
- N‐myc is frequently activated by proviral insertion in MuLV‐induced T cell lymphomas. (1989) (108)
- Tumorigenesis by slow-transforming retroviruses--an update. (1990) (107)
- Structure of Moloney murine leukemia viral DNA: nucleotide sequence of the 5' long terminal repeat and adjacent cellular sequences. (1980) (102)
- Evidence for the involvement of pim‐2, a new common proviral insertion site, in progression of lymphomas. (1989) (99)
- Transgenic mice demonstrate that epithelial homing of gamma/delta T cells is determined by cell lineages independent of T cell receptor specificity (1990) (94)
- Identification of two genes in the unique short region of pseudorabies virus; comparison with herpes simplex virus and varicella-zoster virus. (1990) (92)
- Characterization of AKR murine leukemia virus sequences in AKR mouse substrains and structure of integrated recombinant genomes in tumor tissues (1981) (90)
- E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice. (1991) (90)
- Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP (1999) (88)
- M-MuLV-induced leukemogenesis: Integration and structure of recombinant proviruses in tumors (1981) (87)
- Phase I study of non-replicating autologous tumor cell injections using cells prepared with or without GM-CSF gene transduction in patients with metastatic renal cell carcinoma. (1995) (87)
- Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells. (1993) (87)
- Crosses of two independently derived transgenic mice demonstrate functional complementation of the genes encoding heavy (HLA‐B27) and light (beta 2‐microglobulin) chains of HLA class I antigens. (1987) (86)
- Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells (2002) (84)
- Developmental defects and tumor predisposition in Rb mutant mice (1999) (82)
- Construction and characterization of deletion mutants of pseudorabies virus: a new generation of 'live' vaccines. (1987) (81)
- Self-tolerance to transgenic γδ T cells by intrathymic inactivation (1990) (81)
- Directed expression of the growth-associated protein B-50/GAP-43 to olfactory neurons in transgenic mice results in changes in axon morphology and extraglomerular fiber growth (1995) (81)
- Translation of two messenger RNAs from lens in a cell free system from Krebs II ascites cells. (1972) (80)
- Pim-1 levels determine the size of early B lymphoid compartments in bone marrow (1993) (79)
- Regeneration of herpesviruses from molecularly cloned subgenomic fragments (1988) (77)
- Generation of AKR mink cell focus-forming viruses: a conserved single-copy xenotrope-like provirus provides recombinant long terminal repeat sequences (1984) (77)
- A phase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony stimulating factor. (1997) (75)
- Carcinogen-induced lymphomagenesis in pim-1 transgenic mice: dose dependence and involvement of myc and ras. (1991) (73)
- Use of shuttle vectors to study the molecular processing of defined carcinogen-induced DNA damage: mutagenicity of single O4-ethylthymine adducts in HeLa cells. (1990) (70)
- Blockage of αβ T-cell development by TCR γδ transgenes (1989) (65)
- Pim1 Reconstitutes Thymus Cellularity in Interleukin 7–And Common γ Chain–Mutant Mice and Permits Thymocyte Maturation in Rag- but Not Cd3γ-Deficient Mice (1999) (64)
- Heterologous in vitro synthesis of lens -crystallin polypeptide. (1972) (63)
- MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex. (1997) (62)
- Herpesviruses encode an unusual protein-serine/threonine kinase which is nonessential for growth in cultured cells (1992) (60)
- Molecular cloning of unintegrated and a portion of integrated moloney murine leukemia viral DNA in bacteriophage lambda (1980) (59)
- Genome differences among field isolates and vaccine strains of pseudorabies virus. (1985) (58)
- Mutations in the major histocompatibility complex class I antigen‐presenting groove affect both negative and positive selection of T cells (1990) (56)
- The pseudorabies virus homology of the herpes simplex virus UL21 gene product is a capsid protein which is involved in capsid maturation (1992) (56)
- Evidence for a "non-genetic" origin of the A1 chains of alpha-crystallin. (1972) (56)
- Ribonucleotide reductase-deficient mutants of pseudorabies virus are avirulent for pigs and induce partial protective immunity. (1993) (52)
- The integration sites of endogenous and exogenous Moloney murine leukemia virus (1979) (52)
- Tumor progression in murine leukemia virus-induced T-cell lymphomas: monitoring clonal selections with viral and cellular probes (1986) (51)
- Collaboration of pim-1 and bcl-2 in lymphomagenesis. (1992) (51)
- Comparison of the human and mouse PIM-1 cDNAs: nucleotide sequence and immunological identification of the in vitro synthesized PIM-1 protein. (1987) (49)
- Increase of AKR-specific sequences in tumor tissues of leukemic AKR mice. (1976) (48)
- Presence of markers for virulence in the unique short region or repeat region or both of pseudorabies hybrid viruses (1985) (47)
- Transgenic expression of the muscle-specific intermediate filament protein desmin in nonmuscle cells (1989) (47)
- Complementation tagging of cooperating oncogenes in knockout mice. (1996) (45)
- Diversity, Development, Ligands, and Probable Functions of γδ T Cells (1989) (45)
- A novel tetracycline-dependent transactivator with E2F4 transcriptional activation domain. (2001) (44)
- Calf crystallin synthesis in frog cells: the translation of lens-cell 14S RNA in oocytes. (1972) (44)
- Linker insertion mutagenesis of herpesviruses: inactivation of single genes within the Us region of pseudorabies virus (1990) (42)
- Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways (2010) (40)
- N-terminal acetylation of the nascent chains of α-crystallin (1974) (39)
- Domains of the TCR beta-chain required for early thymocyte development (1996) (36)
- Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene (1995) (35)
- p27kip1-independent cell cycle regulation by MYC (2000) (34)
- Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice. (1996) (34)
- Mouse models for sporadic cancer. (2001) (34)
- Transgenic mice as a means to study synergism between oncogenes (1989) (33)
- Moloney murine leukemia virus-induced tumors: recombinant proviruses in active chromatin regions. (1982) (32)
- A pgk::hprt fusion as a selectable marker for targeting of genes in mouse embryonic stem cells: disruption of the T-cell receptor delta-chain-encoding gene. (1991) (32)
- Diversity, development, ligands, and probable functions of gamma delta T cells. (1991) (32)
- Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domain. (1996) (31)
- Analysis of Pim-1 function in mutant mice. (1993) (30)
- The molecular weight of the 14S calf lens messenger RNA. (1974) (30)
- Synthesis of lens protein in vitro V. Isolation of messenger‐like RNA from lens by high resolution zonal centrifugation (1971) (29)
- Identification and molecular cloning of Moloney mouse sarcoma virus-specific sequences from uninfected mouse cells (1980) (29)
- Tissue‐specific expression of a vimentin–desmin hybrid gene in transgenic mice. (1988) (29)
- [63] Translation of mRNA from vertebrate eye lenses (1974) (28)
- Overexpression of Frat1 in transgenic mice leads to glomerulosclerosis and nephrotic syndrome, and provides direct evidence for the involvement of Frat1 in lymphoma progression (1999) (28)
- Genetic mapping ofPim-1 putative oncogene to mouse chromosome 17 (1986) (28)
- Role of different genes in the virulence and pathogenesis of Aujeszky's disease virus. (1992) (28)
- Molecular cloning of unintegrated Moloney mouse sarcoma virus DNA in bacteriophage lambda. (1980) (28)
- Differentiation of Aujeszky’s Disease Virus Strains by Restriction Endonuclease Analysis of the Viral DNA’s (1982) (27)
- T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous alpha- and beta-genes. (1988) (26)
- T cell receptor-alpha beta lacking the beta-chain V domain can be expressed at the cell surface but prohibits T cell maturation. (1992) (25)
- Mutagenesis and characterization of a 41-kilobase-pair region of the pseudorabies virus genome: transcription map, search for virulence genes, and comparison with homologs of herpes simplex virus type 1. (1994) (24)
- Synergy of Nf2 and p53 mutations in development of malignant tumours of neural crest origin (2004) (23)
- Human-mouse interspecies collagen I heterotrimer is functional during embryonic development of Mov13 mutant mouse embryos (1990) (23)
- Blockage of alpha beta T-cell development by TCR gamma delta transgenes. (1989) (22)
- Molecularly cloned c‐mos(rat) is biologically active. (1982) (20)
- Assignment of the human homologue of Pim-1, a mouse gene implicated in leukemogenesis, to the pter-q12 region of chromosome 6 (1986) (20)
- Mobility of endogenous ecotropic murine leukemia viral genomes within mouse chromosomal DNA and integration of a mink cell focus-forming virus-type recombinant provirus in the germ line (1982) (20)
- Overexpression of the FosB2 gene in thymocytes causes aberrant development of T cells and thymic epithelial cells (1997) (19)
- Proviral activation of the tumor suppressor E2a contributes to T cell lymphomagenesis in EμMyc transgenic mice (2002) (19)
- Synthesis of DNA complementary to 14S calf lens crystallin messenger RNA by reverse transcriptase. (1973) (19)
- Identification and molecular cloning of Moloney mouse sarcoma virus-specific sequences from uninfected mouse cells. (1980) (18)
- Peripheral Neuropathy in Mice Transgenic for a HumanMDR3 P-Glycoprotein Mini-Gene (1996) (16)
- Efficacy of a pseudorabies virus vaccine based on deletion mutant strain 783 that does not express thymidine kinase and glycoprotein I. (1991) (16)
- N-terminal acetylation of the nascent chains of alpha-crystallin. (1974) (16)
- Non-specific stimulation of cell-free protein synthesis by a dialyzable factor isolated from reticulocyte initiation factors ("iRNA"). (1975) (15)
- Diversity, development, ligands, and probable functions of gamma delta T cells. (1989) (15)
- Self-tolerance to transgenic gamma delta T cells by intrathymic inactivation. (1990) (15)
- Immunologic induction of malignant lymphoma: graft-vs-host reaction-induced B cell lymphomas contain integrations of predominantly ecotropic murine leukemia proviruses. (1986) (13)
- H-2-dependent regulation of the high level of expression of ecotropic murine leukemia virus. (1979) (12)
- The separation of α‐ and β‐rabbit globin mRNA by polyacrylamide gel electrophoresis (1974) (12)
- The effect of double-stranded cowpea mosaic viral RNA on protein synthesis. (1975) (11)
- Gene transfer into mammalian embryos. (1987) (11)
- Generation of AKR mink cell focus-forming virus: nucleotide sequence of the 3' end of a somatically acquired AKR-MCF. (1984) (11)
- TRANSGENIC MICE DEMONSTRATE THAT EPITHELIAL HOMING OF y/b T CELLS IS DETERMINED BY CELL LINEAGES INDEPENDENT OF T CELL RECEPTOR SPECIFICITY (2003) (10)
- Translation of mRNA from vertebrate eye lenses. (1974) (8)
- PIM1 Reconstitutes Thymus Cellularity in Interleukin 7– and Common (cid:103) Chain–Mutant Mice and Permits Thymocyte Maturation in Rag- but Not CD3 (cid:103) -deficient Mice (1999) (8)
- Calf lens crystallin messenger RNA's contain polynucleotide sequences rich in adenylic acid. (1974) (7)
- Requirement of a dialyzable component from crude initiation factors for the translation of viral and eukaryotic messenger RNA. (1975) (7)
- Bcl-2 reduces lymphomagenesis in ΔV-TCRβ transgenic mice (1997) (7)
- Proteolytic activity of partly purified ribonuclease inhibitor from rat liver. (1971) (7)
- Bcl-2 reduces lymphomagenesis in deltaV-TCRbeta transgenic mice. (1997) (6)
- GERM LINE INTEGRATION AND LEUKEMOGENESIS OF EXOGENOUS AND ENDOGENOUS MURINE LEUKEMIA VIRUSES (1976) (6)
- Cytoplasmic Messenger RNA (1976) (4)
- Translation of eukaryotic messenger RNA in various heterologous systems (1972) (2)
- The NF2 tumor suppressor gene (1996) (2)
- Synergism Between Oncogenes in T-cell Lymphomagenesis (1989) (1)
- Cardiac-restricted targeting of the retinoblastoma gene reveals a role for Rb in terminal cardiac differentiation and apoptosis (2002) (1)
- Non-Specific Stimulation of Cell-Free Pro Factor Isolated from Reticulocyte Initiati, (2016) (0)
- The role of BRCA1 and BRCA2 loss-of-function in breast cancer (2002) (0)
- Deletion mutant of a herpesvirus and this virus-containing vaccine. (1984) (0)
- Isolation of calf lens messenger RNA and its translation in heterologous systems (1972) (0)
- Deletion mutants of herpes viruses and vaccine containing the virus (1984) (0)
- Mechanisms of Lymphoma Induction by Retroviruses (1986) (0)
- Biosynthesis and function of base J, a new base in the nuclear DNA of kinetoplastid parasites (1993) (0)
- Peripheral T cell survival requires the presence of selecting MHC molecules (1997) (0)
- Increase in Positive Selection of CD8 + T Cells in TAPl-Mutant Mice by Human/~2-Microgl obulln Transgene By Hisse Martien van Santen,* Aaron Woolsey,* (1995) (0)
- Pim-1 Levels Determine the Size o f Early B Lymphoid Compartments in Bone Marrow By Jos Domen (2003) (0)
- The Generation of Transgenic Animals and Their Use in Fundamental Research (1988) (0)
- In vivo functional screens for oncogenic and tumorsuppressive microRNAs (2007) (0)
- The separation of alpha- and beta-rabbit globin mRNA by polyacrylamide gel electrophoresis. (1974) (0)
- Translation of Lens Messenger Ribonucleic Acid in Heterologous Systems (1973) (0)
- A genetically engineered marker vaccine and a companion diagnostic test for the control of pseudorabies virus. (1990) (0)
- Identification and molecular cloning of Moloney mouse sarcoma virus-specific sequences from uninfected mouse cells ( recombinant DNA / restriction endonuclease and Si mapping / electron microscopy ) (0)
- United States Patent ( 19 ) Krimpenfort et al . 54 TRANSGENIC MICE DEPLETED IN MATURE T-CELLS AND METHODS FOR MAKING TRANSGENIC MICE (2017) (0)
- Biogenesis of a transforming gene (1981) (0)
- Dissecting the role of the 9p21 INK4 genes in development and tumor suppression in mouse models (2004) (0)
- Increase in Positive Selection o f C D 8 + T Cells in TAPl-Mutant Mice by Human / ~ 2-Microglobul ln Transgene By Hisse (2003) (0)
- Saturating mutagenesis and characterization of a herpesvirus genome using in vivo reconstitution of virus from cloned subgenomic regions. (1998) (0)
- Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the endoplasmic reticulum in human mesenchymal stem cells (2015) (0)
- 998 Immunotherapy with autologous, irradiated melanoma cells transduced with the GM-CSF gene (1995) (0)
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