Anthony E. Pegg

Q: What Schools Are Affiliated With Anthony E. Pegg

Anthony E. Pegg is affiliated with the following schools: Concordia University, University of South Florida, Pennsylvania State University, Johns Hopkins University, University of Toronto

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Anthony E. Pegg

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#2077

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#3624

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#423

World Rank

#806

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Philosophy

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Anthony E. Pegg's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. (1988) (1575)
Recent advances in the biochemistry of polyamines in eukaryotes. (1986) (1495)
Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. (1990) (748)
Polyamines as targets for therapeutic intervention. (1995) (664)
Mammalian polyamine metabolism and function (2009) (623)
Repair of O6-alkylguanine by alkyltransferases (2000) (497)
Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase. (1995) (492)
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. (1990) (461)
Regulation of Ornithine Decarboxylase* (2006) (417)
Spermidine/spermine N1‐acetyltransferase — the turning point in polyamine metabolism (1993) (416)
Functions of Polyamines in Mammals* (2016) (368)
Polyamine metabolism and cancer: treatments, challenges and opportunities (2018) (355)
On the role of S-adenosyl-L-methionine in the biosynthesis of spermidine by rat prostate. (1969) (350)
Polyamine catabolism and disease. (2009) (312)
Biosynthesis of putrescine in the prostate gland of the rat. (1968) (304)
Formation and metabolism of alkylated nucleosides: possible role in carcinogenesis by nitroso compounds and alkylating agents. (1977) (303)
Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator. (2008) (279)
Repair of O(6)-alkylguanine by alkyltransferases. (2000) (275)
DNA binding and nucleotide flipping by the human DNA repair protein AGT (2004) (267)
Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents. (1991) (265)
Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. (2000) (259)
Repair of DNA containing O6‐alkylguanine (1992) (251)
Concentrations of putrescine and polyamines and their enzymic synthesis during androgen-induced prostatic growth. (1970) (245)
Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide (2007) (243)
Ornithine decarboxylase as an enzyme target for therapy. (1992) (236)
Resuscitation of the monkey brain after one hour complete ischemia. III. Indications of metabolic recovery (1975) (234)
O6-benzylguanine and its role in chemotherapy. (1997) (226)
Inhibition of polyamine metabolism : biological significance and basis for new therapies (1987) (226)
Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation. (1994) (213)
Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma. (1998) (212)
Alkylation of DNA in rat tissues following administration of streptozotocin. (1981) (203)
Purification and properties of O6-methylguanine-DNA transmethylase from rat liver. (1983) (189)
Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. (2002) (188)
Toxicity of polyamines and their metabolic products. (2013) (187)
Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding (2000) (184)
Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites. (1992) (177)
Current status of the polyamine research field. (2011) (176)
Properties of spermidine N-acetyltransferase from livers of rats treated with carbon tetrachloride and its role in the conversion of spermidine into putrescine. (1981) (174)
Ornithine decarboxylase as a target for chemoprevention (1995) (165)
DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. (2007) (161)
The function of spermine (2014) (158)
Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools. (2011) (154)
Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase. (2002) (154)
Activity of temozolomide in the treatment of central nervous system tumor xenografts. (1995) (153)
Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine. (1993) (153)
Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase-overproducing L1210 cells. (1995) (144)
Phosphate-stimulated breakdown of 5'-methylthioadenosine by rat ventral prostate. (1969) (142)
X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome (2003) (140)
O6-alkylguanine-DNA alkyltransferase activity in human brain and brain tumors. (1984) (132)
Enzymatic release of 7-methylguanine from methylated DNA by rodent liver extracts. (1981) (131)
The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor (2002) (130)
Nitric Oxide Inhibits Ornithine Decarboxylase viaS-Nitrosylation of Cysteine 360 in the Active Site of the Enzyme* (2001) (118)
Aminopropyltransferases: function, structure and genetics. (2006) (118)
In vivo effects of α-dl-Difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei (1983) (118)
Correlation between O6-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N'-nitro-N-nitrosoguanidine. (1984) (116)
Translational regulation of ornithine decarboxylase and other enzymes of the polyamine pathway. (1999) (116)
Mechanisms and regulation of polyamine and putrescine biosynthesis in male genital glands and other tissues of mammals. (1969) (115)
Formation and subsequent removal of O6-methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine. (1978) (111)
Spermine synthase (2009) (111)
Repair of O-alkylpyrimidines in mammalian cells: a present consensus. (1988) (109)
S-Adenosylmethionine decarboxylase. (2009) (109)
Alkylation of rat liver DNA by dimethylnitrosamine: effect of dosage on O6-methylguanine levels. (1977) (109)
Changes in mouse kidney ornithine decarboxylase activity are brought about by changes in the amount of enzyme protein as measured by radioimmunoassay. (1983) (107)
Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase. (2000) (106)
Purification of ornithine decarboxylase from kidneys of androgen-treated mice. (1982) (106)
Effect of androgens on turnover of ornithine decarboxylase in mouse kidney. Studies using labeling of the enzyme by reaction with [14C] alpha-difluoromethylornithine. (1982) (105)
S-adenosylmethionine decarboxylase: structure, function and regulation by polyamines. (1998) (104)
The Upstream Open Reading Frame of the mRNA Encoding S-Adenosylmethionine Decarboxylase Is a Polyamine-responsive Translational Control Element* (1996) (104)
[23] Ornithine Decarboxylase (Mouse Kidney) (1983) (102)
Structure and regulation of mammalian S-adenosylmethionine decarboxylase. (1988) (101)
Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine. (2001) (101)
Inactivation and degradation of O(6)-alkylguanine-DNA alkyltransferase after reaction with nitric oxide. (2002) (96)
Formation of O6-methylguanine by alkylation of rat liver, colon, and kidney DNA following administration of 1,2-dimethylhydrazine. (1977) (96)
Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine. (1994) (95)
Cell-specific differences in O6-alkylguanine DNA repair activity during continuous exposure to carcinogen. (1982) (95)
Effect of partial hepatectomy on removal of O6-methylguanine from alkylated DNA by rat liver extracts. (1981) (95)
Inhibition of translation of mRNAs for ornithine decarboxylase and S-adenosylmethionine decarboxylase by polyamines. (1987) (95)
Structure and mechanism of spermidine synthases. (2007) (94)
Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. (1990) (94)
Putrescine biosynthesis in mammalian tissues. (2004) (94)
Effect of alpha-difluoromethylornithine on polyamine and DNA synthesis in regenerating rat liver: reversal of inhibition of DNA synthesis by putrescine. (1982) (93)
Comparison of the rates of repair of O6-alkylguanines in DNA by rat liver and bacterial O6-alkylguanine-DNA alkyltransferase. (1984) (93)
Studies of inhibition of rat spermidine synthase and spermine synthase. (1980) (93)
O6-alkylguanine-DNA alkyltransferase activity in normal human tissues and cells. (1984) (93)
Decarboxylation of ornithine and lysine in rat tissues. (1979) (93)
Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase. (1992) (92)
Sequence specificity of guanine alkylation and repair. (1988) (91)
Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine. (1998) (91)
Effects of inhibitors of spermidine and spermine synthesis on polyamine concentrations and growth of transformed mouse fibroblasts. (1981) (90)
Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase. (1991) (89)
Enzymatic removal of O6-methylguanine from DNA by mammalian cell extracts. (1978) (89)
Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. (2000) (88)
S-adenosylmethionine decarboxylase as an enzyme target for therapy. (1992) (87)
Increase in acetylation of spermidine in rat liver extracts brought about by treatment with carbon tetrachloride. (1980) (84)
Rapid induction of apoptosis by deregulated uptake of polyamine analogues. (1997) (84)
Effect of N1,N12-bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content, and excretion in human colon tumor cells. (1989) (84)
High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma. (1990) (83)
Effect of thioacetamide, growth hormone or partial hepatectomy on spermidine acetylase activity of rat liver cytosol. (1980) (83)
Progress in Polyamine Research (1988) (83)
The α9β1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel (2008) (82)
Stimulation of the decarboxylation of S-adenosylmethionine by putrescine in mammalian tissues. (1968) (82)
Studies of the induction of spermidine/spermine N1-acetyltransferase using a specific antiserum. (1984) (81)
Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide. (2001) (81)
Effect of mutations at active site residues on the activity of ornithine decarboxylase and its inhibition by active site-directed irreversible inhibitors. (1993) (80)
Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft. (2000) (79)
The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine. (1994) (78)
Transgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth. (2003) (78)
Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis. (2001) (77)
Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells (2005) (77)
Regulation of ornithine decarboxylase in a transformed cell line that overexpresses translation initiation factor eIF-4E. (1996) (77)
O6-benzylguanine-mediated enhancement of chemotherapy. (2002) (77)
Glucocorticoid effects on peptide-chain initiation in skeletal muscle and heart. (1978) (77)
Spermine Synthesis Is Required for Normal Viability, Growth, and Fertility in the Mouse* (2004) (77)
Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts. (1991) (76)
Effect of O6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents. (1986) (75)
Repair of O6-propylguanine and O6-butylguanine in DNA by O6-alkylguanine-DNA alkyltransferases from rat liver and E. coli. (1985) (75)
Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-L-methionine decarboxylase inhibitor 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine may be due to hypusine depletion. (1992) (74)
Use of aminopropyltransferase inhibitors and of non-metabolizable analogs to study polyamine regulation and function. (1995) (74)
Paradoxical enhancement of S-adenosylmethionine decarboxylase in rat tissues following administration of the specific inhibitor methyl glyoxal bis(guanylhydrazone). (1973) (73)
Alkylation of nucleic acids and metabolism of small doses of dimethylnitrosamine in the rat. (1981) (72)
8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase. (1995) (71)
DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability. (2003) (71)
Polyamines are needed for the differentiation of 3T3-L1 fibroblasts into adipose cells. (1981) (71)
Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. (2004) (71)
A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine. (1993) (70)
Investigation of structure and rate of synthesis of ornithine decarboxylase protein in mouse kidney. (1984) (70)
S-adenosylmethionine decarboxylase (rat liver). (1983) (70)
Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines. (1985) (69)
Effect of inhibition of polyamine synthesis on the content of decarboxylated S-adenosylmethionine. (1982) (69)
Brain infarction correlates more closely with acrolein than with reactive oxygen species. (2011) (68)
Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. (1992) (68)
Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation. (1999) (68)
Site of pyruvate formation and processing of mammalian S-adenosylmethionine decarboxylase proenzyme. (1989) (68)
Alkylated DNA damage flipping bridges base and nucleotide excision repair (2009) (68)
Escherichia coli S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase. Purification, substrate specificity and mechanism of action. (1985) (68)
Caspase activation in etoposide‐treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion (2002) (67)
Rapid exchange of subunits of mammalian ornithine decarboxylase. (1994) (67)
Cell specific differences in O6-methylguanine-DNA methyltransferase activity and removal of O6-methylguanine in rat pulmonary cells. (1988) (67)
Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine. (1996) (67)
Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis. (2003) (66)
The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants. (2004) (66)
Increased efficiency of translation of ornithine decarboxylase mRNA in mitogen-activated lymphocytes. (1987) (65)
Dimethylnitrosamine inhibits enzymatic removal of O6-methylguanine from DNA (1978) (65)
Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine. (1991) (65)
Crystal Structure of Human Spermine Synthase (2008) (64)
Stimulation of transfer of methyl groups from O6-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins. (1981) (63)
Ornithine decarboxylase induction in transformation by H-Ras and RhoA. (1998) (63)
Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine. (1991) (62)
Kinetic Analysis of Steps in the Repair of Damaged DNA by Human O6-Alkylguanine-DNA Alkyltransferase* (2005) (61)
Effect of inhibition of spermidine formation on protein and nucleic acid synthesis during lymphocyte activation (1973) (61)
Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents. (1985) (61)
Cross-linking of the DNA repair protein Omicron6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards. (2008) (61)
Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase. (1997) (61)
Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). (1993) (61)
Regulation of S-adenosylmethionine decarboxylase activity by alterations in the intracellular polyamine content. (1992) (61)
Multiple pathways for uptake of paraquat, methylglyoxal bis(guanylhydrazone), and polyamines. (1987) (61)
Polyamines and neoplastic growth. (2007) (60)
The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification (2010) (60)
Studies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria. (1985) (60)
The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 A resolution reveals a novel fold. (1999) (60)
Purification of rat liver S-adenosyl-L-methionine decarboxylase. (1974) (58)
Binding of radioactive α-difluoromethylorithine to rat liver ornithine decarboxylase (1981) (58)
Spermidine/spermine N 1-acetyltransferase specifically binds to the integrin α9 subunit cytoplasmic domain and enhances cell migration (2004) (58)
Specific and potent inhibition of spermidine synthase by the transition-state analog, S-adenosyl-3-thio-1,8-diaminooctane. (1980) (57)
Enhancement of the spermidine uptake system and lethal effects of spermidine overaccumulation in ornithine decarboxylase-overproducing L1210 cells under hyposmotic stress. (1993) (57)
Autoradiographic identification of ornithine decarboxylase in mouse kidney by means of alpha-[5-14C]difluoromethylornithine. (1982) (57)
Ornithine decarboxylase (mouse kidney). (1983) (56)
Function of domains of human O6-alkylguanine-DNA alkyltransferase. (2005) (56)
Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase. (1994) (56)
Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane. (2006) (56)
Role of the carboxyl terminal MATEE sequence of spermidine/spermine N1-acetyltransferase in the activity and stabilization by the polyamine analog N1,N12-bis(ethyl)spermine. (1995) (56)
Properties of mammalian O6-alkylguanine-DNA transferases. (1990) (56)
Identification of residues in ornithine decarboxylase essential for enzymic activity and for rapid protein turnover. (1991) (55)
Purification and characterization of spermidine/spermine N1-acetyltransferase from rat liver. (1982) (55)
New SMS mutation leads to a striking reduction in spermine synthase protein function and a severe form of Snyder–Robinson X-linked recessive mental retardation syndrome (2008) (55)
Modulation of cyclophosphamide activity by O 6-alkylguanine-DNA alkyltransferase (1999) (55)
Human variants of O6-alkylguanine-DNA alkyltransferase. (2007) (55)
Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism. (1982) (55)
Post-transcriptional regulation of the content of spermidine/spermine N1-acetyltransferase by N1N12-bis(ethyl)spermine. (1995) (55)
Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase. (1994) (55)
Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target (2006) (54)
Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis. (2002) (54)
Control of ornithine decarboxylase activity in alpha-difluoromethylornithine-resistant L1210 cells by polyamines and synthetic analogues. (1988) (54)
Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase. (1996) (53)
Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. (1989) (53)
O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145. (2003) (53)
Regulation of S-adenosylmethionine decarboxylase activity in rat liver and prostate. (1985) (53)
Regulation of spermidine/spermine N1-acetyltransferase in L6 cells by polyamines and related compounds. (1986) (53)
Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant. (2001) (53)
Effect of 1,3-diaminopropane on ornithine decarboxylase enzyme protein in thioacetamide-treated rat liver. (1983) (53)
Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide. (2003) (52)
Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation. (2001) (52)
Enhancement of Nitrosourea Activity in Medulloblastoma and Glioblastoma Multiforme (1992) (52)
Enzymic synthesis of spermine in rat prostate. (1970) (52)
Ornithine decarboxylase: structure, function and translational regulation. (1994) (52)
Effect of spermine synthase deficiency on polyamine biosynthesis and content in mice and embryonic fibroblasts, and the sensitivity of fibroblasts to 1,3-bis-(2-chloroethyl)-N-nitrosourea. (2000) (52)
Polyamine biosynthesis and interconversion in rodent tissues. (1982) (52)
Properties and physiological function of the polyamine transport system. (1989) (51)
Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis. (2000) (51)
The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase. (2001) (51)
Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1 N12-bis(ethyl)spermine. (1990) (51)
Inhibition of spermidine formation in rat liver and kidney by methylglyoxal bis(guanylhydrazone). (1973) (51)
Studies of the specificity and kinetics of rat liver spermidine/spermine N1-acetyltransferase. (1983) (50)
2-amino-O4-benzylpteridine derivatives: potent inactivators of O6-alkylguanine-DNA alkyltransferase. (2004) (50)
Properties and assay of mammalian O6-alkylguanine-DNA alkyltransferase. (1987) (50)
Decarboxylation of alpha-difluoromethylornithine by ornithine decarboxylase. (1987) (50)
Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells. (2001) (50)
Effects of aliphatic diamines on rat liver ornithine decarboxylase activity. (1978) (50)
Studies on inhibitors of mammalian tRNA methylases (1971) (50)
Proteasomal Degradation of Spermidine/Spermine N 1-Acetyltransferase Requires the Carboxyl-terminal Glutamic Acid Residues* (1997) (50)
Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases. (2000) (49)
alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines. (1992) (49)
Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine. (1995) (49)
Removal of methylated purines from rat liver DNA after administration of dimethylnitrosamine. (1978) (49)
Expression of a human gene for polyamine transport in Chinese-hamster ovary cells. (1989) (49)
Regulation of polyamine transport in Chinese hamster ovary cells (1990) (49)
The role of polyamine depletion and accumulation of decarboxylated S-adenosylmethionine in the inhibition of growth of SV-3T3 cells treated with alpha-difluoromethylornithine. (1984) (48)
Evidence for ethylation of rat liver deoxyribonucleic acid after administration of ethionine. (1971) (48)
Inhibition of diamine oxidase by 1,1-[(methylethanediylidene)-dinitrilo]-bis-(3-aminoguanidine) and 1,1'-[(methylethanediylidene)-dinitrilo]-diguanidine. (1978) (48)
Effect of putrescine on the synthesis of S-adenosylmethionine decarboxylase. (1987) (48)
Measurement of the number of ornithine decarboxylase molecules in rat and mouse tissues under various physiological conditions by binding of radiolabelled alpha-difluoromethylornithine. (1982) (48)
The role of polyamines in somatomedin‐stimulated differentiation of L6 myoblasts (1984) (48)
The effects of diamines and polyamines on enzymic methylation of nucleic acid. (1971) (48)
Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea. (1995) (48)
Investigation of the turnover of rat liver S-adenosylmethionine decarboxylase using a specific antibody. (1979) (47)
Regulation of O6-methylguanine-DNA methyltransferase levels in rat liver and kidney. (1983) (47)
Effects of diamines on ornithine decarboxylase activity in control and virally transformed mouse fibroblasts. (1979) (46)
Interactions of Human O6-Alkylguanine-DNA Alkyltransferase (AGT) with Short Single-stranded DNAs* (2007) (46)
DNA binding mechanism of O6-alkylguanine-DNA alkyltransferase: stoichiometry and effects of DNA base composition and secondary structure on complex stability. (1996) (46)
Expression of mammalian S-adenosylmethionine decarboxylase in Escherichia coli. Determination of sites for putrescine activation of activity and processing. (1994) (46)
Increased content of mRNA for a precursor of S-adenosylmethionine decarboxylase in rat prostate after treatment with 2-difluoromethylornithine. (1986) (45)
Alkylation of intracellular and extracellular DNA by dimethylnitrosamine following activation by isolated rat hepatocytes. (1981) (45)
Characterization of a Mutagenic DNA Adduct Formed from 1,2-Dibromoethane by O6-Alkylguanine-DNA Alkyltransferase* (2004) (45)
Polyamine depletion inhibits the differentiation of L6 myoblast cells. (1983) (45)
Formation and subsequent excision of O6-ethylguanine from DNA of rat liver following administration of diethylnitrosamine. (1979) (45)
Expression of arginase II in prostate cancer. (2008) (45)
Differential inhibition of histone and polyamine acetylases by multisubstrate analogues. (1984) (45)
Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine. (1987) (44)
Repair of O6-methylguanine and O4-methylthymidine in F344 rat liver following treatment with 1,2-dimethylhydrazine and O6-benzylguanine. (1993) (44)
Formation and interconversion of putrescine and spermidine in mammalian cells. (1980) (44)
Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli. (1984) (43)
Paradoxical Enhancement of the Toxicity of 1,2-Dibromoethane byO 6-Alkylguanine-DNA Alkyltransferase* (2002) (43)
Polyamine administration reduces ornithine decarboxylase activity without affecting its mRNA content. (1987) (43)
Induction of spermidine N1-acetyltransferase by dialkylnitrosamines. (1982) (43)
Decarboxylated S-adenosylmethionine in mammalian cells. (1980) (43)
Effect of α-difluoromethylornithine on cardiac polyamine content and hypertrophy (1981) (42)
Regulation of ornithine decarboxylase expression by anisosmotic shock in alpha-difluoromethylornithine-resistant L1210 cells. (1990) (42)
DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma (2013) (42)
Specificity of mammalian spermidine synthase and spermine synthase. (1981) (42)
Effect of starvation on initiation of protein synthesis in skeletal muscle and heart. (1978) (42)
Expression of an ornithine decarboxylase dominant-negative mutant reverses eukaryotic initiation factor 4E-induced cell transformation. (1996) (41)
Treatment of human brain tumor xenografts with O6-benzyl-2'-deoxyguanosine and BCNU. (1996) (41)
O6-Alkylguanine-DNA Alkyltransferase (2011) (41)
A reappraisal of the effects of adenosine 3':5'-cyclic monophosphate on the function and morphology of the rat prostate gland. (1973) (41)
Amino acid residues necessary for putrescine stimulation of human S-adenosylmethionine decarboxylase proenzyme processing and catalytic activity. (1991) (41)
Regulation of mammalian S-adenosylmethionine decarboxylase. (1988) (41)
Polyamine metabolism during cardiac hypertrophy. (1980) (41)
Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase. (1996) (41)
Characterization of transgenic mice with widespread overexpression of spermine synthase. (2004) (40)
Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase. (2008) (40)
Spermine Synthase Deficiency Leads to Deafness and a Profound Sensitivity to α-Difluoromethylornithine*♦ (2009) (39)
Induction of spermidine/spermine N1-acetyltransferase in rat tissues by polyamines. (1985) (39)
Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant. (2003) (39)
Methylation of rat liver mitochondrial deoxyribonucleic acid by chemical carcinogens and associated alterations in physical properties. (1975) (39)
Differences in the rate of repair of O6-alkylguanines in different sequence contexts by O6-alkylguanine-DNA alkyltransferase. (2007) (39)
Effect of inhibitors of S-adenosylmethionine decarboxylase on polyamine content and growth of L1210 cells. (1988) (38)
Alkylating intermediates in nitrosamine metabolism. (1975) (38)
Comparison of S-adenosylmethionine decarboxylases from rat liver and muscle. (1982) (38)
Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism. (2004) (38)
Effect of inhibitors of protein synthesis on rat liver spermidine N-acetyltransferase. (1981) (37)
The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine. (1999) (37)
Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea. (1996) (37)
A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities. (2005) (37)
Colonic polyamine content and ornithine decarboxylase activity as markers for adenomas (1990) (37)
Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis. (2007) (36)
Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells (2011) (36)
Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase†‡ (2008) (36)
Formation of putrescine in rat liver. (1981) (36)
Comparison of inhibitors of S-adenosylmethionine decarboxylase from different species. (1983) (36)
Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase. (2004) (36)
Inhibition of O6-alkylguanine-DNA-alkyltransferase by metals. (1987) (36)
Paramecium bursaria Chlorella Virus-1 Encodes an Unusual Arginine Decarboxylase That Is a Close Homolog of Eukaryotic Ornithine Decarboxylases* (2004) (36)
Induction of spermidine/spermine N1-acetyltransferase by methylglyoxal bis(guanylhydrazone). (1985) (36)
Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase. (1999) (36)
Experimental evidence for structure-activity features in common between mammalian histidine decarboxylase and ornithine decarboxylase. (1996) (35)
Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase. (2003) (35)
Purification of human S-adenosylmethionine decarboxylase expressed in Escherichia coli and use of this protein to investigate the mechanism of inhibition by the irreversible inhibitors, 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine and 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosin (1992) (35)
Rapid and convenient method for the assay of aminopropyltransferases. (1978) (35)
Monomeric S-adenosylmethionine decarboxylase from plants provides an alternative to putrescine stimulation. (2002) (35)
Growth of mammalian cells in the absence of the accumulation of spermine. (1985) (35)
O6-pyridyloxobutylguanine adducts contribute to the mutagenic properties of pyridyloxobutylating agents. (2005) (35)
Role of polyamines in differentiation of 3T3-L1 fibroblasts into adipocytes. (1984) (34)
Effect of analogues of 5'-methylthioadenosine on cellular metabolism. Inactivation of S-adenosylhomocysteine hydrolase by 5'-isobutylthioadenosine. (1983) (34)
Characterization of a full-length cDNA which codes for the human spermidine/spermine N1-acetyltransferase. (1991) (34)
Metabolism of N-nitrosodimethylamine. (1980) (34)
α-Difluoromethylornithine Inhibits N-Nitrosomethylbenzylamine-induced Esophageal Carcinogenesis in Zinc-deficient Rats: Effects on Esophageal Cell Proliferation and Apoptosis (1998) (34)
Studies of the ethylation of rat liver transfer ribonucleic acid after administration of L-ethionine. (1972) (34)
Targeted overexpression of ornithine decarboxylase enhances β-adrenergic agonist-induced cardiac hypertrophy (2001) (34)
Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine. (1999) (34)
Acetylation of decarboxylated S-adenosylmethionine by mammalian cells. (1986) (34)
Inhibition of bacterial aminopropyltransferases by S‐adenosyl‐1,8‐diamino‐3‐thiooctane and by dicyclohexylamine (1983) (33)
Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate. (1988) (33)
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations. (2004) (33)
Investigation of the role of tyrosine-114 in the activity of human O6-alkylguanine-DNA alkyltranferase. (1998) (32)
Evolutionary Links as Revealed by the Structure of Thermotoga maritima S-Adenosylmethionine Decarboxylase* (2004) (32)
Rapid effects of testosterone in prostatic polyamine-synthesizing enzyme systems. (1968) (32)
Brain Tumor Working Group Report on the 9th International Conference on Brain Tumor Research and Therapy (1993) (32)
Induction of spermidine/spermine N1-acetyltransferase activity in Chinese-hamster ovary cells by N1N11-bis(ethyl)norspermine (corrected) and related compounds. (1990) (32)
Effects of inhibitors of ornithine and S‐adenosylmethionine decarboxylases on L6 myoblast proliferation (1982) (32)
In vivo effects of alpha-DL-difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei. (1983) (32)
Altered Spermidine/SpermineN 1-Acetyltransferase Activity as a Mechanism of Cellular Resistance to Bis(ethyl)polyamine Analogues* (2000) (32)
Use of oligodeoxynucleotides containing O6-alkylguanine for the assay of O6-alkylguanine-DNA-alkyltransferase activity. (1988) (32)
Probing of conformational changes in human O6-alkylguanine-DNA alkyl transferase protein in its alkylated and DNA-bound states by limited proteolysis. (1998) (31)
Interactions of human O(6)-alkylguanine-DNA alkyltransferase (AGT) with short double-stranded DNAs. (2008) (31)
Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome). (2011) (31)
Mechanistic Studies of the Processing of Human S-Adenosylmethionine Decarboxylase Proenzyme (1999) (31)
Specific multisubstrate adduct inhibitors of aminopropyltransferases and their effect on polyamine biosynthesis in cultured cells. (1987) (31)
Differential inhibition of mammalian aminopropyltransferase activities. (1978) (31)
Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase. (1989) (30)
Extent of formation of O4-methylthymidine in calf thymus DNA methylated by N-methyl-N-nitrosourea and lack of repair of this product by rat liver O6-alkylguanine-DNA-alkyltransferase. (1985) (30)
Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents. (1989) (30)
The role of human O(6)-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli. (2000) (30)
The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines. (2009) (30)
α-Difluoromethylornithine Induction of Apoptosis A Mechanism Which Reverses Pre-established Cell Proliferation and Cancer Initiation in Esophageal Carcinogenesis in Zinc-deficient Rats (2001) (30)
Mutations in the Ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine. (1995) (30)
Role of the 5'-untranslated region of mRNA in the synthesis of S-adenosylmethionine decarboxylase and its regulation by spermine. (1994) (30)
Repair of O4-Alkylthymine by O6-Alkylguanine-DNA Alkyltransferases* (2009) (30)
DNA sequence context affects repair of the tobacco-specific adduct O(6)-[4-Oxo-4-(3-pyridyl)butyl]guanine by human O(6)-alkylguanine-DNA alkyltransferases. (2006) (30)
Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine. (1999) (30)
An early enlargement of the putrescine pool is required for growth in L1210 mouse leukemia cells under hypoosmotic stress. (1991) (30)
Effects of inhibitors of S-adenosylmethionine decarboxylase and ornithine decarboxylase on DNA synthesis in rat liver after partial hepatectomy. (1978) (29)
Properties of L1210 cells resistant to α-difluoromethylornithine (1988) (29)
Uptake of α-difluoromethylornithine by mouse fibroblasts (1982) (29)
Effects of certain 5'-substituted adenosines on polyamine synthesis: selective inhibitors of spermine synthase. (1986) (29)
Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine. (2003) (29)
Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues. (1994) (29)
Synthesis and characterization of an O(6)-2'-deoxyguanosine-alkyl-O(6)-2'-deoxyguanosine interstrand cross-link in a 5'-GNC motif and repair by human O(6)-alkylguanine-DNA alkyltransferase. (2010) (29)
Molecular Mechanisms of Chemical Carcinogenesis (1975) (29)
Novel DNA repair alkyltransferase from Caenorhabditis elegans (2001) (29)
Inhibition of polyamine metabolism (1988) (29)
Depletion of O6-methylguanine-DNA-methyltransferase in human fibroblasts increases the mutagenic response to N-methyl-N'-nitro-N-nitrosoguanidine. (1985) (29)
Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine. (2008) (29)
Role of cysteine-82 in the catalytic mechanism of human S-adenosylmethionine decarboxylase. (1999) (29)
Repair of oligodeoxynucleotides containing O6-methylguanine by O6-alkylguanine-DNA-alkyltransferase. (1986) (28)
Drugs affecting the cell cycle via actions on the polyamine metabolic pathway. (2003) (28)
Studies of non-metabolizable polyamines that support growth of SV-3T3 cells depleted of natural polyamines by exposure to alpha-difluoromethylornithine. (1988) (28)
Formation and subsequent repair of alkylation lesions in tissues of rodents treated with nitrosamines. (1980) (28)
Increase in S-adenosylmethionine decarboxylase in SV-3T3 cells treated with S-methyl-5'-methylthioadenosine. (1987) (28)
Spermidine uptake by type II pneumocytes: interactions of amine uptake pathways. (1989) (28)
Topologies of complexes containing O6-alkylguanine-DNA alkyltransferase and DNA. (2009) (28)
Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine. (2005) (27)
Activation of human O6-alkylguanine-DNA alkyltransferase by DNA. (1994) (27)
Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy. (2001) (27)
The accumulation of O6-methylguanine in the liver and kidney DNA of rats treated with dimethylinitrosamine for a short or a long period. (1977) (27)
Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea (1997) (27)
Studies on ornithine decarboxylase activity in the isolated perfused rat liver. (1977) (26)
Repair of oligodeoxyribonucleotides by O(6)-alkylguanine-DNA alkyltransferase. (2002) (26)
Inhibition of mammalian S-adenosylmethionine decarboxylase activity by 1,1'-((methylethanediylidene)-dinitrilo)bis(3-aminoguanidine). (1978) (26)
Ornithine decarboxylase from hepatoma cells and a variant cell line in which the enzyme is more stable. (1982) (26)
Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine (2004) (26)
Effects of S-adenosyl-1,8-diamino-3-thio-octane and S-methyl-5'-methylthioadenosine on polyamine synthesis in Ehrlich ascites-tumour cells. (1989) (26)
Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma (2009) (26)
Synthesis of DNA oligonucleotides containing site-specifically incorporated O6-[4-oxo-4-(3-pyridyl)butyl]guanine and their reaction with O6-alkylguanine-DNA alkyltransferase. (1999) (26)
BIOSYNTHESIS OF PUTRESCINE AND POLYAMINES IN MAMMALIAN TISSUES * (1970) (25)
Effects of glucocorticoids on peptide chain initiation in heart and skeletal muscle. (1980) (25)
[40] Inhibitors of S-adenosylmethionine decarboxylase (1983) (25)
New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine† (2009) (25)
Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine. (2000) (25)
Properties of the Spermidine/SpermineN 1-Acetyltransferase Mutant L156F That Decreases Cellular Sensitivity to the Polyamine AnalogueN 1,N 11-Bis(ethyl)norspermine* (2003) (25)
Production of antibodies to peptide sequences present in human O6-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts. (1991) (24)
Investigations of the mechanism by which mammalian cell growth is inhibited by N1N12-bis(ethyl)spermine. (1993) (24)
Progress in polyamine research : novel biochemical, pharmacological, and clinical aspects (1988) (24)
Role of pyridoxal phosphate in mammalian polyamine biosynthesis. Lack of requirement for mammalian S-adenosylmethionine decarboxylase activity. (1977) (24)
In vitro study of proteolytic degradation of rat histidine decarboxylase. (2000) (24)
Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1,N11-diethylnorspermine (2004) (24)
Irreversible inhibition of mamalian and yeast S-adenosylmethionine decarboxylase by 1,1'- (methylethanediylidenedinitrilo)-bis (3-aminoguanidine). (1976) (24)
Mechanism of stimulation of ornithine decarboxylase activity in transformed mouse fibroblasts. (1983) (24)
Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals. (2007) (24)
DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells. (2013) (24)
Synthesis and biochemical evaluation of adenosylspermidine, a nucleoside-polyamine adduct inhibitor of spermidine synthase. (1995) (24)
Quantitation of S-adenosylmethionine decarboxylase protein. (1985) (23)
Regulation of ovarian ornithine decarboxylase by human chorionic gonadotrophin. (1987) (23)
Comparison of ornithine decarboxylase from rat liver, rat hepatoma and mouse kidney. (1985) (23)
Increased transfer ribonucleic acid methylase activity in tumours induced in the mouse colon by the administration of 1,2-dimethylhydrazine. (1971) (22)
Structural Basis of O6-Alkylguanine Recognition by a Bacterial Alkyltransferase-like DNA Repair Protein* (2010) (22)
Polyamine homeostasis in arginase knockout mice. (2007) (22)
Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice. (2006) (22)
Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6-benzylguanine. (1999) (21)
Effect of spermine synthase on the sensitivity of cells to anti-tumour agents. (2003) (21)
Starvation results in decreased initiation factor activity in rat skeletal muscle. (1976) (21)
Alkylation of transfer RNA by N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea. (1973) (21)
Eradication of human medulloblastoma tumor xenografts with a combination of O6-benzyl-2'-deoxyguanosine and 1,3-bis(2-chloroethyl)1-nitrosourea. (1999) (21)
O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate. (2004) (21)
Possible factors in the potentiation of 1-(2-chloroethyl)-3-trans-4-methylcyclohexyl-1-nitrosourea cytotoxicity by alpha-difluoromethylornithine in 9L rat brain tumor cells. (1984) (21)
Effect of expression of human spermidine/spermine N1-acetyltransferase in Escherichia coli. (1995) (21)
Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine. (1999) (21)
Effect of carbon tetrachloride on polyamine metabolism in rodent liver. (1982) (20)
Overexpression of antizyme in the hearts of transgenic mice prevents the isoprenaline-induced increase in cardiac ornithine decarboxylase activity and polyamines, but does not prevent cardiac hypertrophy. (2000) (20)
Detection of proenzyme form of S-adenosylmethionine decarboxylase in extracts from rat prostate. (1988) (20)
Effect of polyamine analogues and inhibition of polyamine oxidase on spermidine/spermine N1-acetyltransferase activity and cell proliferation. (1995) (20)
Differences between tissues in response of S-adenosylmethionine decarboxylase to administration of polyamines. (1981) (20)
Assay of mammalian ornithine decarboxylase activity using [14C]ornithine. (1998) (20)
Enhancing Human Spermine Synthase Activity by Engineered Mutations (2013) (20)
Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]-2'-deoxyguanosine. (2004) (20)
Conversion of exogenous spermidine into putrescine after administration to rats. (1982) (19)
Effects of chronic 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxy- adenosine (AbeAdo) treatment on polyamine and eIF-5A metabolism in AbeAdo-sensitive and -resistant L1210 murine leukaemia cells. (1993) (19)
Interaction of paraquat and amine uptake by rat lungs perfused in situ. (1985) (19)
Metabolism of O6-alkyldeoxyguanosines and their effect on removal of O6-methylguanine from rat liver DNA. (1979) (19)
Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase. (2008) (19)
Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide. (2008) (19)
Reaction ofO 6-Benzylguanine-resistant Mutants of Human O 6-Alkylguanine-DNA Alkyltransferase with O 6-Benzylguanine in Oligodeoxyribonucleotides* (1998) (19)
Mouse models to investigate the function of spermine (2009) (19)
O6-Benzylguanine-mediated enhancement of nitrosourea activity in Mer− central nervous system tumor xenografts – implications for clinical trials (2000) (19)
Human variants of O 6 -alkylguanine-DNA alkyltransferase (2008) (19)
Purification and characterization of some metabolic effects of S-neplanocylmethionine. (1985) (19)
Introduction to the Thematic Minireview Series: Sixty plus years of polyamine research (2018) (18)
Kinetics of O(6)-methyl-2'-deoxyguanosine repair by O(6)-alkylguanine DNA alkyltransferase within K-ras gene-derived DNA sequences. (2006) (18)
Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus. (2003) (18)
Spermidine uptake by type II pulmonary epithelial cells in primary culture. (1989) (18)
DNAzyme-mediated silencing of ornithine decarboxylase. (2005) (18)
Effect ofO6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer (2004) (17)
Effect of pretreatment with other dialkylnitrosamines on excision from hepatic DNA of O6-methylguanine produced by dimethylnitrosamine. (1978) (17)
Induction of spermidine N1-acetyltransferase by sodium n-butyrate and phytohemagglutinin in bovine lymphocytes. (1983) (17)
O(6)-methylguanine-DNA methyltransferase activity, p53 gene status and BCNU resistance in mouse astrocytes. (1999) (17)
Metabolism of dimethylnitrosamine and subsequent removal of O6-methylguanine from DNA by isolated rat hepatocytes. (1981) (17)
Further investigation of the increased transfer ribonucleic acid methylase activity in tumours of the mouse colon. (1974) (17)
Effects of the S-adenosylmethionine decarboxylase inhibitor, 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine, on cell growth and polyamine metabolism and transport in Chinese hamster ovary cell cultures. (1994) (17)
Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine. (2007) (17)
Irreversible inhibition of S-adenosylmethionine decarboxylase of Trypanosoma brucei brucei by S-adenosylmethionine analogues. (1992) (17)
Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications. (2008) (17)
In Silico Chemical Library Screening and Experimental Validation of a Novel 9-Aminoacridine Based Lead-Inhibitor of Human S-Adenosylmethionine Decarboxylase (2007) (17)
Assay of spermidine and spermine synthases. (1998) (17)
Nucleotide sequence of hamster spermidine/spermine-N1-acetyltransferase cDNA. (1992) (17)
Occurrence and induction of spermidine-N1-acetyltransferase in Escherichia coli. (1982) (17)
Cytosine Methylation Effects on the Repair of O6-Methylguanines within CG Dinucleotides* (2009) (16)
Autoradiographic localization of ornithine decarboxylase. (1983) (16)
Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase. (1996) (16)
5 – The Use of Inhibitors to Study the Biochemistry and Molecular Biology of Polyamine Biosynthesis and Uptake (1987) (16)
Inactivation of human O(6)-alkylguanine-DNA alkyltransferase by modified oligodeoxyribonucleotides containing O(6)-benzylguanine. (2001) (16)
O6-alkylguanine-DNA alkyltransferases repair O6-methylguanine in DNA with Michaelis-Menten-like kinetics. (2003) (15)
Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine. (2000) (15)
Use of a dodecadeoxynucleotide to study repair of the O4-methylthymine lesion. (1988) (15)
Alkylation of DNA and carcinogenicity of N-nitroso compounds. (1980) (15)
Effects of growth hormone and glucagon on ornithine decarboxylase activity and adenosine 3',5'-monophosphate levels in isolated rat hepatocytes. (1980) (15)
Effect of inhibitors of S-adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S-adenosylmethionine decarboxylase in L1210 cells. (1988) (15)
Characterization of transgenic mice with overexpression of spermidine synthase (2012) (15)
Kinetics of repair of O6-methylguanine in dna by O6-methylguanine-DNA methyltransferase in vitro and in vivo. (1982) (15)
Potentiation of BCNU antitumor efficacy by 9-substituted O6-benzylguanines. Effect of metabolism (2000) (14)
Effect of DNA on the inactivation of O6-alkylguanine-DNA alkyltransferase by 9-substituted O6-benzylguanine derivatives. (1997) (14)
Inhibition of the alkylation of nucleic acids and of the metabolism of 1,2-dimethylhydrazine by aminoacetonitrile. (1978) (14)
[26] Autoradiographic localization of ornithine decarboxylase (1983) (14)
Assay of aminopropyltransferases. (1983) (14)
Methylation of purified transfer RNA preparations by extracts derived from rat kidney and kidney tumours. (1972) (14)
Properties of the O6-alkylguanine-DNA repair system of mammalian cells. (1984) (14)
Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation. (2002) (14)
Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase. (2013) (14)
Spermidine/spermine N1-acetyltransferase transient overexpression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin. (2005) (14)
Formation and removal of methylated nucleosides in nucleic acids of mammalian cells. (1983) (14)
Pharmacologic interference with enzymes of polyamine biosynthesis and of 5'-Methylthioadenosine metabolism (1987) (14)
Investigation of Sequence Specificity in DNA Alkylation and Repair Using Oligodeoxynucleotide Substrates (1989) (14)
Potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in 9L rat brain tumor cells by methylglyoxal-bis(guanylhydrazone), an inhibitor of S-adenosyl-L-methionine decarboxylase. (1984) (14)
Effects of androgens on incorporation of labeled amino acids into proteins by prostate mitochondria. (1968) (13)
Involvement of polyamines in the progestin-induced stimulation of endometrial glycogen synthesis during organ culture. (1977) (13)
The decarboxylation of S-adenosylmethionine by detergent-treated extracts of rat liver. (1979) (13)
Introduction: Polyamine Metabolism (1987) (13)
Effects of Inhibition of O6‐Alkylguanine‐DNA Alkyltransferase in Rats on Carcinogenesis by Methylnitrosourea and Ethylnitrosourea (1994) (13)
Inhibition of spermidine synthase gene expression by transforming growth factor-beta 1 in hepatoma cells. (1997) (13)
Spermine synthase activity affects the content of decarboxylated S-adenosylmethionine. (2011) (13)
Specific labeling of O6-alkylguanine-DNA alkyltransferase by reaction with O6-(p-hydroxy[3H]methylbenzyl)guanine. (1995) (13)
Inhibition of cytomegalovirus-stimulated human cell ornithine decarboxylase by alpha-difluoromethylornithine. (1979) (12)
Polyamine depletion inhibits etoposide-induced NF-κB activation in transformed mouse fibroblasts (2004) (12)
Effect of 1-amino-oxy-3-aminopropane on polyamine metabolism and growth of L1210 cells. (1989) (12)
Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells. (2010) (12)
The effect of trypsin digestion and ionic strength on RNA polymerase of rat liver. (1967) (12)
Putrescine activated S-adenosylmethionine decarboxylase from Trypanosoma brucei brucei (1992) (12)
Regulation of polyamine content in cultured fibroblasts. (1982) (12)
The effects of chronic ethanol administration on polyamine content during dimethylhydrazine-induced colorectal carcinogenesis in the rat. (1988) (12)
Investigation of the specificity of O6-alkylguanine-DNA-alkyltransferase. (1988) (12)
Changes in tRNA methylase activity of rat kidney following administration of the carcinogen, dimethylnitrosamine. (1972) (12)
The role of tyrosine-158 in O6-alkylguanine-DNA alkyltransferase activity. (1995) (12)
Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy (2012) (11)
Properties of human and rodent S-adenosylmethionine decarboxylase. (1988) (11)
Inhibition of aminopropyltransferases. (1983) (11)
Sites of methylation of purified transfer ribonucleic acid preparations by enzymes from normal tissues and from tumours induced by dimethylnitrosamine and 1,2-dimethylhydrazine. (1974) (11)
Absence of inactivation or phosphorylation of ornithine decarboxylase by nuclear protein kinase NII and of immunological cross-reactivity between RNA polymerase I and ornithine decarboxylase. (1984) (11)
Interaction of mammalian O6-alkylguanine-DNA alkyltransferases with O6-benzylguanine (2002) (11)
Alpha-difluoromethylornithine inhibits N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in zinc-deficient rats: effects on esophageal cell proliferation and apoptosis. (1998) (11)
Role of unsaturated derivatives of spermidine as substrates for spermine synthase and in supporting growth of SV-3T3 cells. (1991) (11)
The dual action of the non-physiological diamines 1,3 diaminopropane and cadaverine on ornithine decarboxylase of HTC cells. (1980) (11)
Mechanism of depletion of O6-methylguanine-DNA methyltransferase activity in rat tissues by O6-Benzyl-2'-deoxyguanosine. Role of metabolism. (1996) (11)
Nuclear-localizing O6-benzylguanine-resistant GFP-MGMT fusion protein as a novel in vivo selection marker. (2004) (11)
Effect of N-(n-butyl)-1,3-diaminopropane on polyamine metabolism, cell growth and sensitivity to chloroethylating agents. (1993) (11)
Stable intracellular acidification upon polyamine depletion induced by alpha-difluoromethylornithine or N1,N12-bis(ethyl)spermine in L1210 leukaemia cells. (1995) (10)
Formationof 06-Methylguanineby Alkylationof Rat Liver, Colon, and Kidney DNA followingAdministrationof (1977) (10)
Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA. (2011) (10)
Studies of mammalian ornithine decarboxylase using a monoclonal antibody. (1984) (10)
Role of aldehydes in the toxic and mutagenic effects of nitrosamines. (2013) (10)
Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane. (2007) (10)
Measurement of the amount of ornithine decarboxylase in Saccharomyces cerevisiae and Saccharomyces uvarum by using alpha-[5-14C]difluoromethylornithine. (1983) (10)
Effect of O6‐alkylguanine‐DNA alkyltransferase on genotoxicity of epihalohydrins (2009) (10)
POL Y AMINES AS TARGETS FOR THERAPEUTIC INTERVENTION (1995) (10)
Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice. (2013) (9)
Methylation of purified transfer RNAs by liver extracts from normal and mestranol-treated rats. (1973) (9)
Gene sequences coding for S-adenosylmethionine decarboxylase are present on human chromosome 6 and the X and are not amplified in colon neoplasia. (1988) (9)
[55] Spermidine N1-acetyltransferase (1983) (9)
Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine. (2002) (9)
Effect of O 6-Benzylguanine on Alkylating Agent-induced Toxicity and Mutagenicity in Chinese Hamster Ovary Cells Expressing Wild-Type and Mutant O 6-Alkylguanine-DNA Alkyltransferases 1 (2000) (9)
The effects ofO6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells (2004) (9)
Stereochemistry of the decarboxylation of l-ornithine with ornithine decarboxylase from mouse kidney (1984) (9)
Effect of hypophysectomy on persistence of methylated purines in rat liver deoxyribonucleic acid after administration of dimethylnitrosamine. (1978) (9)
O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases. (1998) (9)
Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells (2006) (9)
Production of N1-acetyl spermidine by renal cell tumors. (1989) (8)
Alkylation of messenger RNA by dimethylnitrosamine (1976) (8)
Studies of the base composition of transfer rna and the specificity of transfer rna methylases of hamster liver (1975) (8)
Mechanisms of Differential Strain Sensitivity in Gastric Carcinogenesis (1988) (8)
Carrier-mediated uptake of methylglyoxal bis(guanylhydrazone) by rat lungs perfused in situ. (1985) (8)
Methylation of yeast aspartic acid transfer RNA by rat liver extracts (1972) (8)
Nucleotide sequence of hamster S-adenosylmethionine decarboxylase cDNA. (1992) (8)
Studies of the acetyl-CoA-binding site of rat liver spermidine/spermine N1-acetyltransferase. (1983) (8)
Kinetics of O(6)-pyridyloxobutyl-2'-deoxyguanosine repair by human O(6)-alkylguanine DNA alkyltransferase. (2013) (8)
Tissue-based Assay for Ornithine Decarboxylase to Identify Patients Likely to Respond to Difluoromethylornithine (2004) (8)
Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats. (2001) (8)
DNA repair pathways and cancer prevention. (1999) (7)
Metabolism and disposition of O6-benzyl-2'-deoxyguanosine in Sprague-Dawley rats. (1994) (7)
Inhibitors of S-adenosylmethionine decarboxylase. (1983) (7)
O 6-Benzylguanine-mediated Enhancement of Chemotherapy 1 (2002) (7)
Assay of mammalian S-adenosylmethionine decarboxylase activity. (1998) (7)
Bioditribution ofO6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL (2004) (6)
Effects of sequence context on O6-alkylguanine DNA alkyltransferase repair of O6-alkyl-deoxyguanosine adducts (2010) (6)
Repair of alkylated DNA by cell extracts from various organs and species. (1983) (6)
Autoradiographic localization of ornithine decarboxylase in mouse kidney by use of radiolabeled α-difluoromethylornithine (2004) (5)
The in vitro interaction of alpha-difluoromethyl ornithine (DFMO) and several interferons on human cell lines. (1985) (5)
Effect of alpha-difluoromethylornithine on cardiac polyamine content and hypertrophy. (1981) (5)
Properties of L1210 cells resistant to alpha-difluoromethylornithine. (1988) (5)
DNA Repair and Carcinogenesis by Alkylating Agents (1990) (5)
Directions for polyamine research (1991) (5)
Inhibition of aminopropyltransferases by S‐adenosylmethionine (1980) (5)
Primary structure of rat spermidine synthase: an example of refining the cDNA-derived amino acid sequence. (1999) (4)
In Silico Chemical Library Screening and Experimental Validation of a Novel 9‐Aminoacridine Based Lead‐Inhibitor of Human S‐Adenosylmethionine Decarboxylase. (2007) (4)
Reactivity of analogues of S-adenosylmethionine in the enzymic synthesis of spermidine by mammalian tissues. (1969) (4)
Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity. (2010) (4)
12 – INHIBITION OF POLYAMINE BIOSYNTHESIS AND FUNCTION AS AN APPROACH TO DRUG DESIGN (1989) (4)
Overcoming Resistance to Alkylating Agents by Inhibitors of O 6-Alkylguanine-DNA Alkyltransferase (2004) (4)
Specificity of O6-alkylguanine-DNA alkyltransferase. (1987) (4)
Labeling and quantitation of ornithine decarboxylase protein by reaction with alpha-[5-14C]difluoromethylornithine. (1983) (4)
Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase synthesis by antisense oligodeoxynucleotides (1992) (4)
Biosynthesis and accumulation of decarboxylated S-adenosylmethionine (1982) (4)
O 6-Alkylguanine-DNA Alkyltransferase Activity in Normal Human Tissues and Cells (2006) (4)
KINETICS OF O6-Me-dG REPAIR BY O6-ALKYLGUANINE DNA ALKYLTRANSFERASE WITHIN K-RAS GENE DERIVED DNA SEQUENCES (2011) (3)
Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii (2008) (3)
Binding of radioactive alpha-difluoromethylornithine to rat liver ornithine decarboxylase. (1981) (3)
Uptake of alpha-difluoromethylornithine by mouse fibroblasts. (1982) (3)
L-Arginine at the Crossroads of Biochemical Pathways Involved in Myocardial Hypertrophy (2003) (2)
Specificity of transfer ribonucleic acid methylases from normal mouse colon and 1,2-dimethylhydrazine-induced colon tumours. (1972) (2)
Chlorella Virus PBCV-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases (2004) (2)
Determination of cellular decarboxylated S-adenosylmethionine content. (1983) (2)
Ornithine as a possible marker of cancer. (1979) (2)
HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE (1999) (2)
Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine (2008) (2)
α-Difluoromethylornithine Induction of Apoptosis (2001) (2)
Saturation of repair system for O6-methylguanine in rat liver DNA by pretreatment with cyclic nitrosamines. (1984) (2)
DNA-binding Mechanism ofO 6-Alkylguanine-DNA Alkyltransferase (2003) (2)
Induction of spermidine / spermine N 1-acetyltransferase activity in Chinese-hamster ovary cells by N ' NN 1-bis ( ethyl ) norspermidine and related compounds (2005) (2)
Structure/function relationship studies on the T/S residues 173-177 of rat ODC. (1998) (2)
Spermidine N-acetyltransferase. (1983) (2)
Antizyme inhibits N-nitrosomethylbenzylamine-induced mouse forestomach carcinogenesis in a p53-independent manner (2005) (1)
An encyclopedia of polyamines (1998) (1)
acetyltransferase activity increases susceptibility to skin carcinogenesis (2007) (1)
Repair of O6-alkylguanine in cellular DNA: significance for tumour induction and chemotherapy (1984) (1)
HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE COVALENTLY CROSSLINKED TO DNA (2004) (1)
Determination of cellular aminopropyltransferase activity using precolumn fluorescent etheno-derivatization with high-performance liquid chromatography. (2012) (1)
Basic principles in nucleic acid chemistry Vol. 1, edited by P. O. P. Ts'o. Pp xii + 636. Academic Press, Inc., New York, 1974. $37.50; E18a00 (1975) (1)
Unique Characteristics of the Parasite Polyamine Pathway. (2018) (1)
Regulation of O 6-Methylguanine-DNA Methyltransferase Levels in Rat Liver and Kidney 1 (2006) (1)
Dauter Complexes of Thermotoga maritima S-adenosylmethionine decarboxylase provide insights into substrate specificity (2010) (1)
Use of (Gyro) Gy and spermine synthase transgenic mice to study functions of spermine. (2011) (1)
Enhancing Human Spermine Synthase Activity by Site Directed Mutations (2013) (1)
Abstract 2483: Transgenic mice to evaluate the role of S-adenosylmethionine decarboxylase in skin carcinogenesis (2010) (1)
PROPERTIES OF HUMAN AND RODENT S-ADENOSYLME 11 ll 0 NINE DECARBOXYLASE (0)
Tumor Cells to the Cytotoxic Effects of Alkylating Agents-Benzylguanine Analogues on Sensitivity of Human 6 O Effect of Updated (2006) (0)
Effect of Chronic Treatment of Ratswith Dimethylnitrosamineon the Removalof 06-Methylguaninefrom DNA1 (1980) (0)
Structure of Thermotoga maritima S63A non-processing mutant S-adenosylmethionine decarboxylase (2004) (0)
to protect the use of gene therapy to alkyltransferases uungsmitteln (1997) (0)
Effects of mutation at glutamic acid 247 on activity and kinetic parameters of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase. (2007) (0)
Crystal Structure of Spermidine Synthase in Complex with Transition State Analogue AdoDATO (2001) (0)
Formationand Lossof Alkylated Purines from DNA of Hamster Liver after Administrationof Dimethylnitrosamine ' (2006) (0)
Leukocyte O 6-Alkylguanine-DNA Alkyltransferase from Human Donors Is Uniformly Sensitive to O 6-Benzylguanine 1 (1999) (0)
THE GENERATION OF CHEMICALLY REACTIVE METABOLITES : a Colloquium organized on behalf of the Molecular Enzymology Group (2009) (0)
Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy (2011) (0)
Degradation of BRCA 2 in Alkyltransferase-Mediated DNA Repair and Its Clinical Implications (2008) (0)
Compounds guanine, guanosine and 2'-deoxyguanosine benzylated in o6 possessing activity depletion o6 -alkylguanine-DNA alkyltransferase. (1991) (0)
Human AdoMetDC with 5'-[(4-aminooxybutyl)methylamino]-5'deoxy-8-ethyladenosine (2009) (0)
S-adenosylmethionine in the inhibition of growth of SV-3T3 cells treated with o-difluoromethylornithine (2005) (0)
Pegg and as a Target for Chemotherapy Polyamine Metabolism and Its Importance in Neoplastic Growth (2006) (0)
Induction of Spermidine A/1-Acetyltransferase by Dialkylnitrosamines1 (1982) (0)
O6-benzylated guanine, guanosine and 2'-deoxyguanosine compounds with O6-alkylguanine-DNA alkyltransferase decimated Activity (1991) (0)
Ornithine Decarboxylase (ODC) is the initial enzyme in the polyamine biosynthetic pathway (2001) (0)
Polyamines reviewed (1981) (0)
Alkylation of DMA in Rat Tissues following Administration of Streptozotocin 1 (2004) (0)
Crystal structure of S-adenosylmethionine decarboxylase from potato (2002) (0)
Substituted 6(4)-benzyloxypyrimidines (1995) (0)
Crystal Structure of human Spermidine Synthase in Complex with decarboxylated S-adenosylhomocysteine (2011) (0)
HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COVALENTLY BOUND S-ADENOSYLMETHIONINE METHYL ESTER (2001) (0)
Repair and Its Clinical Implications Degradation of BRCA 2 in Alkyltransferase-Mediated DNA (2008) (0)
Human AdoMetDC E178Q mutant complexed with putrescine (2008) (0)
Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells (2011) (0)
Plasma and CNS pharmacokinetics of O4-benzylfolic acid (O4BF) and metabolite in a non-human primate model (2011) (0)
Growth hormone stimulation of ornithine decarboxylase activity in isolated rat hepatocytes (1977) (0)
Abstract #3208: Ornithine decarboxylase and antizyme 2 are prognostic markers for aggressive neuroblastoma independent of MYCN amplification status (2009) (0)
Decreased arginase II expression in androgen-independent prostate cancer cell lines. (2006) (0)
Acknowledgement to reviewers (2004) (0)
Effect of 06-Benzylguanine Analogues on Sensitivity of Human Tumor Cells to the Cytotoxic Effects of Alkylating Agents 1 (2006) (0)
Crystal Structure of Spermidine Synthase from Thermotoga Maritima (2001) (0)
HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COVALENTLY BOUND 5'-DEOXY-5'-[(3-HYDRAZINOPROPYL)METHYLAMINO]ADENOSINE (2001) (0)
Human AdoMetDC D174N mutant with no putrescine bound (2008) (0)
Chapter 6 Mammalian DNA Repair Enzymes (2018) (0)
Human AdoMetDC with covalently bound 5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine (2009) (0)
6 (4) -benciloxipirimidinas substituted. (1995) (0)
Effect of 06-Alkylguanine Pretreatment on the Sensitivity of Human Colon Tumor Cells to the Cytotoxic Effects of Chloroethy lating Agents1 (2006) (0)
Evidence forEthylation ofRatLiverDeoxyribonucleic Acidafter Administration ofEthionine (1971) (0)
Human AdoMetDC with no putrescine bound (2008) (0)
Transformation Translational Repression Is Associated with Neoplastic Overproduction of Ornithine Decarboxylase Caused by Relief of Updated (2006) (0)
Human AdoMetDC F223A mutant with covalently bound S-Adenosylmethionine methyl ester (2009) (0)
Kinins V (1989) (0)
Inhibitors of Ornithine and S-Adenosylmethionine Decarboxylases (2021) (0)
Chapter 4:Inhibitors of Polyamine Biosynthetic Enzymes (2011) (0)
The role of an eIF2-like initiation factor in the control of peptidechain initiation in heart and skeletal muscle* (1977) (0)
Advances in Brief Expression of an Ornithine Decarboxylase Dominant-Negative Mutant Reverses Eukaryotic Initiation Factor 4 E-induced Cell Transformation ' (2006) (0)
HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COMPLEXED WITH 4-AMIDINOINDAN-1-ONE-2'-AMIDINOHYDRAZONE (2001) (0)
Sequence specificity of guanine methylation and repair (1988) (0)
MutationsinHuman 06-Alkylguamne-DNAAlkyltransferaseImpartingResistance to 06-Benzylguamne ' (2006) (0)
Effect of 06-Methylguanine on DNA Interstrand Chloroethylnitrosoureas and Z-ChloroethyKmethylsulfonyOmethanesulfonate1 (2006) (0)
Human AdoMetDC with 5'-[(2-carboxamidoethyl)methylamino]-5'-deoxy-8-methyladenosine (2009) (0)
Alkylation of meseenger RNA by dimethylnitrosamine. (1976) (0)
The S68A S-adenosylmethionine decarboxylase proenzyme processing mutant. (2003) (0)
Human AdoMetDC D174N mutant complexed with S-Adenosylmethionine methyl ester and no putrescine bound (2008) (0)
Oligodeoxynucleotides as substrates for O/sup 6/-alkylguanine-DNA alkyltransferase (AGT) (1986) (0)
Properties of LI 210 Cells Resistant to a-Difluoromethylornithine1 (2006) (0)
HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COMPLEXED WITH METHYLGLYOXAL BIS-(GUANYLHYDRAZONE) (2001) (0)
HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COVALENTLY BOUND 5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE (2001) (0)
Inhibition of S-adenosylmethionine decarboxylase activity and polyamine synthesis in vivo (1977) (0)
Characterization of transgenic mice with overexpression of spermidine synthase (2011) (0)
HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE BOUND TO DNA CONTAINING O6-METHYLGUANINE (2004) (0)
Author Index / Subject Index Vol. 49, 1988 (1988) (0)
Human AdoMetDC E256Q mutant complexed with putrescine (2008) (0)
Polyamine metabolism and cancer: treatments, challenges and opportunities (2018) (0)
Factors influencing carcinogenesis by alkylating agents. (1991) (0)
O6-substituted benzilguaninas. (1995) (0)
Inhibition of ornithine decarboxylase activity by diamines in control and transformed fibroblasts (1979) (0)
Crystal Structure of Thermotoga maritima S-adenosylmethionine decarboxylase (2004) (0)

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