Alex J. Van Der Eb

Alex J. Van Der Eb's AcademicInfluence.com Rankings

Alex J. Van Der Eb

Biology

#6275

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#8952

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Virology

#129

World Rank

#133

Historical Rank

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Biology

Alex J. Van Der Eb's Degrees

PhD Virology Leiden University
Masters Biology Leiden University

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Alex J. Van Der Eb's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A new technique for the assay of infectivity of human adenovirus 5 DNA. (1973) (8295)
Transformation of rat cells by DNA of human adenovirus 5. (1973) (661)
Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. (1996) (549)
New helper cells and matched early region 1-deleted adenovirus vectors prevent generation of replication-competent adenoviruses. (1998) (493)
Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA. (1980) (413)
A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides. (1986) (345)
WT1 proteins: functions in growth and differentiation. (2001) (324)
Studies on in vitro transformation by DNA and DNA fragments of human adenoviruses and simian virus 40. (1975) (289)
A single chicken anemia virus protein induces apoptosis (1994) (281)
Assay of transforming activity of tumor virus DNA. (1980) (278)
Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. (1997) (251)
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms (2001) (248)
Mutations in N-ras predominate in acute myeloid leukemia. (1987) (238)
IκBα is a target for the mitogen‐activated 90 kDa ribosomal S6 kinase (1997) (237)
Chicken anemia virus causes apoptosis of thymocytes after in vivo infection and of cell lines after in vitro infection (1992) (217)
Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells (1995) (176)
Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast cell lines is associated with methylation and dependent on its chromosomal position (1991) (170)
Localization of the E1B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies. (1985) (163)
Transformation with specific fragments of adenovirus DNAs. I. Isolation of specific fragments with transforming activity of adenovirus 2 and 5 DNA. (1977) (162)
Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53. (2001) (159)
Three different mutations in codon 61 of the human N-ras gene detected by synthetic oligonucleotide hybridization. (1984) (157)
Apoptin, a protein derived from chicken anemia virus, induces p53-independent apoptosis in human osteosarcoma cells. (1995) (157)
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx. (1997) (152)
Heat shock protein 27 and alpha B-crystallin can form a complex, which dissociates by heat shock. (1992) (151)
Hdmx stabilizes Mdm2 and p53. (2000) (144)
Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells. (1985) (138)
The Wilms' tumor 1 gene: oncogene or tumor suppressor gene? (1998) (129)
The nucleotide sequence of the transforming HpaI-E fragment of adenovirus type 5 DNA. (1978) (117)
Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation. (1998) (116)
Internal Translation Initiation Generates Novel WT1 Protein Isoforms with Distinct Biological Properties* (1999) (114)
Molecular cloning and biological characterization of the human excision repair gene ERCC-3 (1990) (111)
The Chicken Anemia Virus-Derived Protein Apoptin Requires Activation of Caspases for Induction of Apoptosis in Human Tumor Cells (2000) (104)
Immunogenic and protective properties of chicken anaemia virus proteins expressed by baculovirus. (1995) (103)
Protective anti-tumor immunity induced by vaccination with recombinant adenoviruses encoding multiple tumor-associated cytotoxic T lymphocyte epitopes in a string-of-beads fashion. (1997) (101)
How phosphorylation regulates the activity of p53. (1996) (101)
A human gastric carcinoma contains a single mutated and an amplified normal allele of the Ki-ras oncogene. (1986) (100)
Characterization of cells transformed by Ad5/Ad12 hybrid early region I plasmids. (1982) (97)
Poly(A) tail shortening is the translation-dependent step in c-myc mRNA degradation (1990) (94)
Expression of the blood-clotting factor-VIII cDNA is repressed by a transcriptional silencer located in its coding region. (1995) (94)
Simultaneous expression of recombinant baculovirus-encoded chicken anaemia virus (CAV) proteins VP1 and VP2 is required for formation of the CAV-specific neutralizing epitope. (1998) (90)
Structure and function of the transforming genes of human adenoviruses and SV40. (1980) (86)
Toward Gene Therapy in Haemophilia A: Retrovirus-Mediated Transfer of a Factor VIII Gene into Murine Haematopoietic Progenitor Cells (1992) (85)
Characterization of tumor antigens in cells transformed by fragments of adenovirus type 5 DNA. (1979) (81)
The relationship between region E1a and E1b of human adenoviruses in cell transformation. (1982) (80)
Expression of functional factor VIII in primary human skin fibroblasts after retrovirus-mediated gene transfer. (1990) (79)
Adenovirus E1A proteins inhibit activation of transcription by p53 (1996) (78)
Expression of region E1b of human adenoviruses in the absence of region E1a is not sufficient for complete transformation. (1983) (78)
Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family (1990) (77)
An adenovirus type 5 early region 1B-encoded CTL epitope-mediating tumor eradication by CTL clones is down-modulated by an activated ras oncogene. (1995) (75)
Toward gene therapy for hemophilia A: long-term persistence of factor VIII-secreting fibroblasts after transplantation into immunodeficient mice. (1993) (73)
Expression of human adenosine deaminase in mice transplanted with hemopoietic stem cells infected with amphotropic retroviruses (1990) (67)
Apoptin, a protein encoded by chicken anemia virus, induces cell death in various human hematologic malignant cells in vitro. (1995) (66)
Role of adenovirus types 5 and 12 early region 1b tumor antigens in oncogenic transformation. (1983) (65)
Identification of adenovirus-type 12 gene products involved in transformation and oncogenesis. (1982) (63)
Phosphorylation of a specific cdk site in E2F-1 affects its electrophoretic mobility and promotes pRB-binding in vitro. (1995) (62)
Mammalian nucleotide excision repair. (1995) (61)
Post-transcriptional control of class I MHC mRNA expression in adenovirus 12-transformed cells. (1987) (60)
Transcription of the chicken anemia virus (CAV) genome and synthesis of its 52-kDa protein. (1992) (58)
Mutational analysis of ERCC3, which is involved in DNA repair and transcription initiation: identification of domains essential for the DNA repair function (1994) (57)
IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. (1997) (56)
Activation of N-ras induced by ultraviolet irradiation in vitro. (1988) (56)
Wilms' tumor 1-KTS isoforms induce p53-independent apoptosis that can be partially rescued by expression of the epidermal growth factor receptor or the insulin receptor. (1997) (55)
UV-reactivation, virus production and mutagenesis of SV40 in VU-irradiated monkey kidney cells. (1980) (55)
Physical Interaction between Wilms Tumor 1 and p73 Proteins Modulates Their Functions* (2000) (55)
Similar effects of adenovirus E1A and glucocorticoid hormones on the expression of the metalloprotease stromelysin. (1988) (54)
Differentiation of P19 EC cells leads to differential modulation of cyclin-dependent kinase activities and to changes in the cell cycle profile. (1995) (54)
Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines. (1993) (54)
Role of the adenovirus early region 1B tumor antigens in transformation and lytic infection. (1986) (53)
The adenovirus E1A-associated 300 kDa adaptor protein counteracts the inhibition of the collagenase promoter by E1A and represses transformation. (1996) (49)
Host-cell reactivation of ultraviolet-irradiated SV40 DNA in five complementation groups of xeroderma pigmentosum. (1976) (49)
Adenovirus: transformation and oncogenicity. (1984) (48)
The repression of the growth factor-inducible genes JE, c-myc and stromelysin by adenovirus E1A is mediated by conserved region 1. (1989) (47)
BCL-2 stimulates Apoptin-induced apoptosis. (1999) (47)
Morphological transformation of human adenoviruses is determined to a large extent by gene products of region E1a. (1983) (47)
Differential sensitivity to Ad5 E1B-21kD and Bcl-2 proteins of apoptin-induced versus p53-induced apoptosis. (1995) (47)
The G1/S cell-cycle checkpoint in eukaryotic cells. (1994) (46)
Cloning of human adenosine deaminase cDNA and expression in mouse cells. (1984) (45)
Enhanced reactivation and enhanced mutagenesis of herpes simplex virus in normal human and xeroderma pigmentosum cells (1984) (43)
Rapid c-myc mRNA degradation does not require (A + U)-rich sequences or complete translation of the mRNA. (1991) (43)
Isolation of cDNA clones for human adenosine deaminase. (1983) (43)
Transformation and immortalization of diploid xeroderma pigmentosum fibroblasts. (1990) (41)
In vitro synthesis of adenovirus type 5 T antigens. I. Translation of early region 1-specific rna from lytically infected cells (1981) (41)
Wilms' tumor 1 splice variants have opposite effects on the tumorigenicity of adenovirus-transformed baby-rat kidney cells. (1996) (40)
A role for Rad23 proteins in 26S proteasome-dependent protein degradation? (2002) (40)
The human clotting factor VIII cDNA contains an autonomously replicating sequence consensus- and matrix attachment region-like sequence that binds a nuclear factor, represses heterologous gene expression, and mediates the transcriptional effects of sodium butyrate (1996) (40)
Possible involvement of normal p21 H-ras in the insulin/insulinlike growth factor 1 signal transduction pathway (1989) (40)
Transformation of primary rat kidney cells by fragments of simian virus 40 DNA (1975) (39)
The xeroderma pigmentosum group B protein ERCC3 produced in the baculovirus system exhibits DNA helicase activity. (1994) (38)
In Vitro Transformation of Rat and Mouse Cells by DNA from Simian Virus 40 (1975) (38)
Detection of chicken anaemia virus by DNA hybridization and polymerase chain reaction. (1992) (38)
Identification and mapping of the early gene products of adenovirus type 12. (1980) (37)
Intestinal and extra-intestinal tumor multiplicities in the Apc1638N mouse model after exposure to X-rays. (1997) (37)
Cyclin‐dependent kinases and pRb: regulators of the proliferation‐differentiation switch (1995) (36)
Transformation with specific fragments of adenovirus DNAs. II. Analysis of the viral DNA sequences present in cells transformed with a 7% fragment of adenovirus 5 DNA. (1977) (34)
Distinct modulation of p53 activity in transcription and cell-cycle regulation by the large (54 kDa) and small (21 kDa) adenovirus E1B proteins. (1995) (34)
Adenovirus type 12 E1A down regulates expression of a transgene under control of a major histocompatibility complex class I promoter: evidence for transcriptional control (1989) (34)
Transformation of primary rat kidney cells by DNA fragments of weakly oncogenic adenoviruses (1979) (34)
The expression of heat shock protein hsp27 and a complexed 22-kilodalton protein is inversely correlated with oncogenicity of adenovirus-transformed cells (1989) (33)
Adenosine deaminase (ADA) deficiency in cells derived from humans with severe combined immunodeficiency is due to an aberration of the ADA protein. (1984) (33)
Identification of the promoter region of chicken anemia virus (CAV) containing a novel enhancer-like element. (1994) (33)
Apoptin specifically causes apoptosis in tumor cells and after UV-treatment in untransformed cells from cancer-prone individuals: a review. (1998) (33)
Reduced binding activity of transcription factor NF-kappa B accounts for MHC class I repression in adenovirus type 12 E 1-transformed cells. (1992) (32)
The genetic background modifies the spontaneous and X‐ray–induced tumor spectrum in the Apc1638N mouse model (1999) (32)
The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains (1995) (32)
Identical 3250-bp deletion between two AluI repeats in the ADA genes of unrelated ADA-SCID patients. (1990) (32)
Adenovirus E1A represses transcription of the cellular JE gene (1989) (30)
Different activities of the adenovirus types 5 and 12 E1A regions in transformation with the EJ Ha-ras oncogene (1986) (30)
Mif1: a missing link between the unfolded protein response pathway and ER-associated protein degradation? (2001) (29)
Localization of the xeroderma pigmentosum group B-correcting gene ERCC3 to human chromosome 2q21. (1991) (29)
The adenoviral E1A oncoproteins interfere with the growth-inhibiting effect of the cdk-inhibitor p21(CIP1/WAF1). (1999) (28)
The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300. (1997) (27)
Characterization of the mouse homolog of the XPBC/ERCC-3 gene implicated in xeroderma pigmentosum and Cockayne's syndrome. (1991) (27)
BAG-1 inhibits p53-induced but not apoptin-induced apoptosis (2004) (27)
Differential regulation of the Wilms' tumor gene, WT1, during differentiation of embryonal carcinoma and embryonic stem cells. (1997) (26)
Intermediates in type 5 adenovirus DNA replication. (1973) (26)
The viral protein Apoptin induces apoptosis in UV-C-irradiated cells from individuals with various hereditary cancer-prone syndromes. (1999) (26)
Altered AP-1/ATF complexes in adenovirus-E1-transformed cells due to EIA-dependent induction of ATF3. (1996) (25)
Structure and expression of the human XPBC/ERCC-3 gene involved in DNA repair disorders xeroderma pigmentosum and Cockayne's syndrome. (1991) (25)
Severe combined immune deficiency due to a homozygous 3.2-kb deletion spanning the promoter and first exon of the adenosine deaminase gene. (1987) (25)
Transformation and oncogenicity by adenoviruses. (1984) (25)
Gene therapy for human inherited disorders: techniques and status. (1992) (24)
Deletion mutants of region E1a of AD12 E1 plasmids: effect on oncogenic transformation. (1983) (24)
Different regulation of p53 stability in UV-irradiated normal and DNA repair deficient human cells. (1995) (24)
High levels of enhanced reactivation of herpes simplex virus in skin fibroblasts from various hereditary cancer-prone syndromes. (1992) (23)
X-ray-induced lymphomagenesis in E mu-pim-1 transgenic mice: an investigation of the co-operating molecular events. (1998) (23)
Impaired DNA repair capacity in skin fibroblasts from various hereditary cancer-prone syndromes. (1998) (21)
Analysis of polyadenylation site usage of the c-myc oncogene. (1989) (21)
Molecular and functional analysis of the XPBC/ERCC-3 promoter: transcription activity is dependent on the integrity of an Sp1-binding site. (1992) (21)
The effect of UV-irradiation on the plaque-forming ability of single- and double-stranded polyoma virus DNA. (1967) (21)
Large E1B proteins of adenovirus types 5 and 12 have different effects on p53 and distinct roles in cell transformation (1993) (21)
Transfection with extracellularly UV-damaged DNA induces human and rat cells to express a mutator phenotype towards parvovirus H-1 (1984) (21)
E1A + cHa-ras transformed rat embryo fibroblast cells are characterized by high and constitutive DNA binding activities of AP-1 dimers with significantly altered composition. (1999) (21)
The CR1 and CR3 domains of the adenovirus type 5 E1A proteins can independently mediate activation of ATF-2 (1996) (20)
Protein kinase C-alpha is an upstream activator of the IkappaB kinase complex in the TPA signal transduction pathway to NF-kappaB in U2OS cells. (2000) (20)
Localization of human adenosine deaminase (ADA) gene sequences to the q12----q13.11 region of chromosome 20 by in situ hybridization. (1989) (20)
Chicken anemia virus strains with a mutated enhancer/promoter region share reduced virus spread and cytopathogenicity. (1998) (20)
Differential Expression of Tapasin and Immunoproteasome Subunits in Adenovirus Type 5- Versus Type 12-transformed Cells* (2003) (19)
Introduction of sequences encoding functional human adenosine deaminase into mouse cells using a retroviral shuttle system. (1985) (19)
Structural properties of adenovirus DNA's. (1969) (19)
Oncogenicity by adenovirus is not determined by the transforming region only (1984) (19)
In vitro synthesis of adenovirus type 5 T antigens. II. Translation of virus-specific RNA from cells transformed by fragments of adenovirus type 5 DNA (1981) (19)
E1A products of adenoviruses reduce the expression of cellular proliferation-associated genes. (1988) (19)
Modulation of gene expression by adenovirus transformation. (1995) (19)
The effect of cell irradiation on mutation in ultraviolet-irradiated and intact simian virus 40. (1981) (19)
Bloom's syndrome cells GM1492 lack detectable p53 protein but exhibit normal G1 cell-cycle arrest after UV irradiation. (1994) (18)
Construction and characterization of an adenovirus type 5/adenovirus type 12 recombinant virus. (1983) (18)
Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent. (1990) (18)
Impaired recovery and mutagenic SOS-like responses in ataxia telangiectasia cells. (1989) (17)
p53 shares an antigenic determinant with proteins of 92 and 150 kilodaltons that may be involved in senescence of human cells (1992) (17)
Transfection of human lymphoblastoid cells with herpes simplex viral DNA. (1979) (15)
Expression of avian leukaemia virus env-gp85 in Spodoptera frugiperda cells by use of a baculovirus expression vector. (1990) (15)
Adenovirus E1A antagonizes both negative and positive growth signals elicited by transforming growth factor beta 1. (1995) (14)
Absence of induction of enhanced reactivation of herpes simplex virus in cells from xeroderma pigmentosum patients without skin cancer. (1988) (14)
Enhanced induction of SV40 replication from transformed rat cells by fusion with UV-irradiated normal and repair-deficient human fibroblasts. (1986) (13)
Survival of UV-irradiated vaccinia virus in normal and xeroderma pigmentosum fibroblasts; evidence for repair of UV-damaged viral DNA. (1994) (13)
Co-regulated expression of junB and MHC class I genes in adenovirus-transformed cells. (1991) (13)
GM1492 human diploid skin fibroblasts lack the p53-dependent G1 cell-cycle checkpoint. (1995) (13)
Induction of the mitogen-activated p70 S6 kinase by adenovirus E1A. (1995) (12)
Site of proline hydroxylation during collagen synthesis in mouse fibroblasts. (1970) (12)
Expression, purification, and functional characterization of adenovirus 5 and 12 E1A proteins produced in insect cells. (1992) (12)
Altered phosphorylation and oligomerization of p53 in adenovirus type 12-transformed cells. (1995) (11)
Tumor- and growth-related membrane changes caused by transformation with different fragments of the adenovirus 12 genome. (1982) (11)
Immunosurveillance of virus-induced tumors. (1989) (11)
Down-regulation of T-STAR, a growth inhibitory protein, after SV40-mediated immortalization. (2001) (11)
Enhanced induction of SV40 replication from transformed mammalian cells by fusion with UV-irradiated untransformed cells. (1985) (10)
A lack of radiation-induced ornithine decarboxylase activity prevents enhanced reactivation of herpes simplex virus and is linked to non-cancer proneness in xeroderma pigmentosum patients. (1997) (10)
Cells transformed by adenovirus type 12 but not by type 5 are dependent on insulin or insulin-like growth factor I for their proliferation. (1988) (9)
Adenosine deaminase gene expression is regulated posttranscriptionally in the nucleus. (1988) (9)
Analysis of virus-specific mRNAs present in cells transformed with restriction fragments of adenovirus type 5 DNA. (1983) (9)
Inheritance of abnormal expression of SOS-like response in xeroderma pigmentosum and hereditary cancer-prone syndromes. (1996) (9)
Differentially expressed transcripts in x‐ray induced lymphomas identified by dioxygenin‐labeled differential display (1999) (8)
Transcription of the transforming region of adenovirus type 5 in a rat cell line transformed by a small restriction fragment (1978) (8)
Apoptin-induced apoptosis: potential for antitumor therapy. (1998) (7)
Mutagenesis in UV-irradiated simian virus 40 occurs predominantly at pyrimidine doublets. (1985) (7)
Towards integrating vectors for gene therapy: expression of functional bacteriophage MuA and MuB proteins in mammalian cells. (2000) (6)
Insertion of the human cytomegalovirus enhancer into a myeloproliferative sarcoma virus long terminal repeat creates a high-expression retroviral vector. (1994) (6)
Temperature-sensitive mutant p53 (ala143) interferes transiently with DNA-synthesis and cell-cycle progression in Saos-2 cells. (1996) (6)
Homologous recombination is not enhanced in UV-irradiated normal and repair-deficient human fibroblasts. (1989) (6)
Differential effect of ultraviolet light on the induction of simian virus 40 and a cellular mutator phenotype in transformed mammalian cells. (1985) (6)
Side effects of suicide gene therapy. (2004) (6)
Transforming properties of a 15-kDa truncated Ad12 E1A gene product. (1986) (5)
Repression of cyclin D1 expression does not contribute to initiation or maintenance of cell transformation by adenovirus type 5 E1 (1996) (4)
Adenosine deaminase mRNA expression is regulated posttranscriptionally during differentiation of HL-60 cells. (1987) (4)
Suppression of cellular gene activity in adenovirus-transformed cells. (1989) (3)
Factors impeding efficient expression of factor VIII complementary DNA minigenes. (1997) (3)
Abnormal kinetics of induction of UV-stimulated recombination in human DNA repair disorders. (2003) (2)
Different adenovirus E1A-controlled properties of transformed cells require different levels of E1A expression. (1987) (2)
[Changes in the composition of transcription factor AP-1 in rat embryonal fibroblast cells, transformed by E1A and Ha-Ras oncogenes]. (1999) (2)
[Cells of patients with ataxia telangiectasia show a normal capacity of radio-induced reactivation of damaged HSV-1 virus]. (1987) (1)
How to deal with potential contaminations of monoclonal antibody preparations. (1990) (1)
Induction of differentiation-regulated transcription factor Oct-6 specifically accompanies major histocompatibility complex class I down-regulation by E1A of oncogenic adenovirus type 12. (1995) (1)
The role of oncogenes in the pathogenesis of cancer. (1986) (0)
Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells (1985) (0)
Dominant and recessive oncogenes in carcinogenesis. (1988) (0)
Unusual Interactions of Adenovirus 5 and 12 E1B Proteins with p53 (1993) (0)
Response to apoptin of diploid fibroblasts from cancer-prone syndromes. (2001) (0)
Transformation by DNA viral oncogenes. (2001) (0)
Oncogenes and malignant transformation. (1986) (0)
Induction of polyploidy in adenovirus E1-transformed cells by the mitotic inhibitor colcemid. (1996) (0)