Alex J. Van Der Eb
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Alex J. Van Der Ebbiology Degrees
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Virology
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Alex J. Van Der Eb's Degrees
- PhD Virology Leiden University
- Masters Biology Leiden University
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(Suggest an Edit or Addition)Alex J. Van Der Eb's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A new technique for the assay of infectivity of human adenovirus 5 DNA. (1973) (8295)
- Transformation of rat cells by DNA of human adenovirus 5. (1973) (661)
- Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. (1996) (549)
- New helper cells and matched early region 1-deleted adenovirus vectors prevent generation of replication-competent adenoviruses. (1998) (493)
- Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA. (1980) (413)
- A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides. (1986) (345)
- WT1 proteins: functions in growth and differentiation. (2001) (324)
- Studies on in vitro transformation by DNA and DNA fragments of human adenoviruses and simian virus 40. (1975) (289)
- A single chicken anemia virus protein induces apoptosis (1994) (281)
- Assay of transforming activity of tumor virus DNA. (1980) (278)
- Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. (1997) (251)
- Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms (2001) (248)
- Mutations in N-ras predominate in acute myeloid leukemia. (1987) (238)
- IκBα is a target for the mitogen‐activated 90 kDa ribosomal S6 kinase (1997) (237)
- Chicken anemia virus causes apoptosis of thymocytes after in vivo infection and of cell lines after in vitro infection (1992) (217)
- Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells (1995) (176)
- Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast cell lines is associated with methylation and dependent on its chromosomal position (1991) (170)
- Localization of the E1B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies. (1985) (163)
- Transformation with specific fragments of adenovirus DNAs. I. Isolation of specific fragments with transforming activity of adenovirus 2 and 5 DNA. (1977) (162)
- Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53. (2001) (159)
- Three different mutations in codon 61 of the human N-ras gene detected by synthetic oligonucleotide hybridization. (1984) (157)
- Apoptin, a protein derived from chicken anemia virus, induces p53-independent apoptosis in human osteosarcoma cells. (1995) (157)
- Isolation and identification of the human homolog of a new p53-binding protein, Mdmx. (1997) (152)
- Heat shock protein 27 and alpha B-crystallin can form a complex, which dissociates by heat shock. (1992) (151)
- Hdmx stabilizes Mdm2 and p53. (2000) (144)
- Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells. (1985) (138)
- The Wilms' tumor 1 gene: oncogene or tumor suppressor gene? (1998) (129)
- The nucleotide sequence of the transforming HpaI-E fragment of adenovirus type 5 DNA. (1978) (117)
- Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation. (1998) (116)
- Internal Translation Initiation Generates Novel WT1 Protein Isoforms with Distinct Biological Properties* (1999) (114)
- Molecular cloning and biological characterization of the human excision repair gene ERCC-3 (1990) (111)
- The Chicken Anemia Virus-Derived Protein Apoptin Requires Activation of Caspases for Induction of Apoptosis in Human Tumor Cells (2000) (104)
- Immunogenic and protective properties of chicken anaemia virus proteins expressed by baculovirus. (1995) (103)
- Protective anti-tumor immunity induced by vaccination with recombinant adenoviruses encoding multiple tumor-associated cytotoxic T lymphocyte epitopes in a string-of-beads fashion. (1997) (101)
- How phosphorylation regulates the activity of p53. (1996) (101)
- A human gastric carcinoma contains a single mutated and an amplified normal allele of the Ki-ras oncogene. (1986) (100)
- Characterization of cells transformed by Ad5/Ad12 hybrid early region I plasmids. (1982) (97)
- Poly(A) tail shortening is the translation-dependent step in c-myc mRNA degradation (1990) (94)
- Expression of the blood-clotting factor-VIII cDNA is repressed by a transcriptional silencer located in its coding region. (1995) (94)
- Simultaneous expression of recombinant baculovirus-encoded chicken anaemia virus (CAV) proteins VP1 and VP2 is required for formation of the CAV-specific neutralizing epitope. (1998) (90)
- Structure and function of the transforming genes of human adenoviruses and SV40. (1980) (86)
- Toward Gene Therapy in Haemophilia A: Retrovirus-Mediated Transfer of a Factor VIII Gene into Murine Haematopoietic Progenitor Cells (1992) (85)
- Characterization of tumor antigens in cells transformed by fragments of adenovirus type 5 DNA. (1979) (81)
- The relationship between region E1a and E1b of human adenoviruses in cell transformation. (1982) (80)
- Expression of functional factor VIII in primary human skin fibroblasts after retrovirus-mediated gene transfer. (1990) (79)
- Adenovirus E1A proteins inhibit activation of transcription by p53 (1996) (78)
- Expression of region E1b of human adenoviruses in the absence of region E1a is not sufficient for complete transformation. (1983) (78)
- Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family (1990) (77)
- An adenovirus type 5 early region 1B-encoded CTL epitope-mediating tumor eradication by CTL clones is down-modulated by an activated ras oncogene. (1995) (75)
- Toward gene therapy for hemophilia A: long-term persistence of factor VIII-secreting fibroblasts after transplantation into immunodeficient mice. (1993) (73)
- Expression of human adenosine deaminase in mice transplanted with hemopoietic stem cells infected with amphotropic retroviruses (1990) (67)
- Apoptin, a protein encoded by chicken anemia virus, induces cell death in various human hematologic malignant cells in vitro. (1995) (66)
- Role of adenovirus types 5 and 12 early region 1b tumor antigens in oncogenic transformation. (1983) (65)
- Identification of adenovirus-type 12 gene products involved in transformation and oncogenesis. (1982) (63)
- Phosphorylation of a specific cdk site in E2F-1 affects its electrophoretic mobility and promotes pRB-binding in vitro. (1995) (62)
- Mammalian nucleotide excision repair. (1995) (61)
- Post-transcriptional control of class I MHC mRNA expression in adenovirus 12-transformed cells. (1987) (60)
- Transcription of the chicken anemia virus (CAV) genome and synthesis of its 52-kDa protein. (1992) (58)
- Mutational analysis of ERCC3, which is involved in DNA repair and transcription initiation: identification of domains essential for the DNA repair function (1994) (57)
- IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. (1997) (56)
- Activation of N-ras induced by ultraviolet irradiation in vitro. (1988) (56)
- Wilms' tumor 1-KTS isoforms induce p53-independent apoptosis that can be partially rescued by expression of the epidermal growth factor receptor or the insulin receptor. (1997) (55)
- UV-reactivation, virus production and mutagenesis of SV40 in VU-irradiated monkey kidney cells. (1980) (55)
- Physical Interaction between Wilms Tumor 1 and p73 Proteins Modulates Their Functions* (2000) (55)
- Similar effects of adenovirus E1A and glucocorticoid hormones on the expression of the metalloprotease stromelysin. (1988) (54)
- Differentiation of P19 EC cells leads to differential modulation of cyclin-dependent kinase activities and to changes in the cell cycle profile. (1995) (54)
- Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines. (1993) (54)
- Role of the adenovirus early region 1B tumor antigens in transformation and lytic infection. (1986) (53)
- The adenovirus E1A-associated 300 kDa adaptor protein counteracts the inhibition of the collagenase promoter by E1A and represses transformation. (1996) (49)
- Host-cell reactivation of ultraviolet-irradiated SV40 DNA in five complementation groups of xeroderma pigmentosum. (1976) (49)
- Adenovirus: transformation and oncogenicity. (1984) (48)
- The repression of the growth factor-inducible genes JE, c-myc and stromelysin by adenovirus E1A is mediated by conserved region 1. (1989) (47)
- BCL-2 stimulates Apoptin-induced apoptosis. (1999) (47)
- Morphological transformation of human adenoviruses is determined to a large extent by gene products of region E1a. (1983) (47)
- Differential sensitivity to Ad5 E1B-21kD and Bcl-2 proteins of apoptin-induced versus p53-induced apoptosis. (1995) (47)
- The G1/S cell-cycle checkpoint in eukaryotic cells. (1994) (46)
- Cloning of human adenosine deaminase cDNA and expression in mouse cells. (1984) (45)
- Enhanced reactivation and enhanced mutagenesis of herpes simplex virus in normal human and xeroderma pigmentosum cells (1984) (43)
- Rapid c-myc mRNA degradation does not require (A + U)-rich sequences or complete translation of the mRNA. (1991) (43)
- Isolation of cDNA clones for human adenosine deaminase. (1983) (43)
- Transformation and immortalization of diploid xeroderma pigmentosum fibroblasts. (1990) (41)
- In vitro synthesis of adenovirus type 5 T antigens. I. Translation of early region 1-specific rna from lytically infected cells (1981) (41)
- Wilms' tumor 1 splice variants have opposite effects on the tumorigenicity of adenovirus-transformed baby-rat kidney cells. (1996) (40)
- A role for Rad23 proteins in 26S proteasome-dependent protein degradation? (2002) (40)
- The human clotting factor VIII cDNA contains an autonomously replicating sequence consensus- and matrix attachment region-like sequence that binds a nuclear factor, represses heterologous gene expression, and mediates the transcriptional effects of sodium butyrate (1996) (40)
- Possible involvement of normal p21 H-ras in the insulin/insulinlike growth factor 1 signal transduction pathway (1989) (40)
- Transformation of primary rat kidney cells by fragments of simian virus 40 DNA (1975) (39)
- The xeroderma pigmentosum group B protein ERCC3 produced in the baculovirus system exhibits DNA helicase activity. (1994) (38)
- In Vitro Transformation of Rat and Mouse Cells by DNA from Simian Virus 40 (1975) (38)
- Detection of chicken anaemia virus by DNA hybridization and polymerase chain reaction. (1992) (38)
- Identification and mapping of the early gene products of adenovirus type 12. (1980) (37)
- Intestinal and extra-intestinal tumor multiplicities in the Apc1638N mouse model after exposure to X-rays. (1997) (37)
- Cyclin‐dependent kinases and pRb: regulators of the proliferation‐differentiation switch (1995) (36)
- Transformation with specific fragments of adenovirus DNAs. II. Analysis of the viral DNA sequences present in cells transformed with a 7% fragment of adenovirus 5 DNA. (1977) (34)
- Distinct modulation of p53 activity in transcription and cell-cycle regulation by the large (54 kDa) and small (21 kDa) adenovirus E1B proteins. (1995) (34)
- Adenovirus type 12 E1A down regulates expression of a transgene under control of a major histocompatibility complex class I promoter: evidence for transcriptional control (1989) (34)
- Transformation of primary rat kidney cells by DNA fragments of weakly oncogenic adenoviruses (1979) (34)
- The expression of heat shock protein hsp27 and a complexed 22-kilodalton protein is inversely correlated with oncogenicity of adenovirus-transformed cells (1989) (33)
- Adenosine deaminase (ADA) deficiency in cells derived from humans with severe combined immunodeficiency is due to an aberration of the ADA protein. (1984) (33)
- Identification of the promoter region of chicken anemia virus (CAV) containing a novel enhancer-like element. (1994) (33)
- Apoptin specifically causes apoptosis in tumor cells and after UV-treatment in untransformed cells from cancer-prone individuals: a review. (1998) (33)
- Reduced binding activity of transcription factor NF-kappa B accounts for MHC class I repression in adenovirus type 12 E 1-transformed cells. (1992) (32)
- The genetic background modifies the spontaneous and X‐ray–induced tumor spectrum in the Apc1638N mouse model (1999) (32)
- The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains (1995) (32)
- Identical 3250-bp deletion between two AluI repeats in the ADA genes of unrelated ADA-SCID patients. (1990) (32)
- Adenovirus E1A represses transcription of the cellular JE gene (1989) (30)
- Different activities of the adenovirus types 5 and 12 E1A regions in transformation with the EJ Ha-ras oncogene (1986) (30)
- Mif1: a missing link between the unfolded protein response pathway and ER-associated protein degradation? (2001) (29)
- Localization of the xeroderma pigmentosum group B-correcting gene ERCC3 to human chromosome 2q21. (1991) (29)
- The adenoviral E1A oncoproteins interfere with the growth-inhibiting effect of the cdk-inhibitor p21(CIP1/WAF1). (1999) (28)
- The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300. (1997) (27)
- Characterization of the mouse homolog of the XPBC/ERCC-3 gene implicated in xeroderma pigmentosum and Cockayne's syndrome. (1991) (27)
- BAG-1 inhibits p53-induced but not apoptin-induced apoptosis (2004) (27)
- Differential regulation of the Wilms' tumor gene, WT1, during differentiation of embryonal carcinoma and embryonic stem cells. (1997) (26)
- Intermediates in type 5 adenovirus DNA replication. (1973) (26)
- The viral protein Apoptin induces apoptosis in UV-C-irradiated cells from individuals with various hereditary cancer-prone syndromes. (1999) (26)
- Altered AP-1/ATF complexes in adenovirus-E1-transformed cells due to EIA-dependent induction of ATF3. (1996) (25)
- Structure and expression of the human XPBC/ERCC-3 gene involved in DNA repair disorders xeroderma pigmentosum and Cockayne's syndrome. (1991) (25)
- Severe combined immune deficiency due to a homozygous 3.2-kb deletion spanning the promoter and first exon of the adenosine deaminase gene. (1987) (25)
- Transformation and oncogenicity by adenoviruses. (1984) (25)
- Gene therapy for human inherited disorders: techniques and status. (1992) (24)
- Deletion mutants of region E1a of AD12 E1 plasmids: effect on oncogenic transformation. (1983) (24)
- Different regulation of p53 stability in UV-irradiated normal and DNA repair deficient human cells. (1995) (24)
- High levels of enhanced reactivation of herpes simplex virus in skin fibroblasts from various hereditary cancer-prone syndromes. (1992) (23)
- X-ray-induced lymphomagenesis in E mu-pim-1 transgenic mice: an investigation of the co-operating molecular events. (1998) (23)
- Impaired DNA repair capacity in skin fibroblasts from various hereditary cancer-prone syndromes. (1998) (21)
- Analysis of polyadenylation site usage of the c-myc oncogene. (1989) (21)
- Molecular and functional analysis of the XPBC/ERCC-3 promoter: transcription activity is dependent on the integrity of an Sp1-binding site. (1992) (21)
- The effect of UV-irradiation on the plaque-forming ability of single- and double-stranded polyoma virus DNA. (1967) (21)
- Large E1B proteins of adenovirus types 5 and 12 have different effects on p53 and distinct roles in cell transformation (1993) (21)
- Transfection with extracellularly UV-damaged DNA induces human and rat cells to express a mutator phenotype towards parvovirus H-1 (1984) (21)
- E1A + cHa-ras transformed rat embryo fibroblast cells are characterized by high and constitutive DNA binding activities of AP-1 dimers with significantly altered composition. (1999) (21)
- The CR1 and CR3 domains of the adenovirus type 5 E1A proteins can independently mediate activation of ATF-2 (1996) (20)
- Protein kinase C-alpha is an upstream activator of the IkappaB kinase complex in the TPA signal transduction pathway to NF-kappaB in U2OS cells. (2000) (20)
- Localization of human adenosine deaminase (ADA) gene sequences to the q12----q13.11 region of chromosome 20 by in situ hybridization. (1989) (20)
- Chicken anemia virus strains with a mutated enhancer/promoter region share reduced virus spread and cytopathogenicity. (1998) (20)
- Differential Expression of Tapasin and Immunoproteasome Subunits in Adenovirus Type 5- Versus Type 12-transformed Cells* (2003) (19)
- Introduction of sequences encoding functional human adenosine deaminase into mouse cells using a retroviral shuttle system. (1985) (19)
- Structural properties of adenovirus DNA's. (1969) (19)
- Oncogenicity by adenovirus is not determined by the transforming region only (1984) (19)
- In vitro synthesis of adenovirus type 5 T antigens. II. Translation of virus-specific RNA from cells transformed by fragments of adenovirus type 5 DNA (1981) (19)
- E1A products of adenoviruses reduce the expression of cellular proliferation-associated genes. (1988) (19)
- Modulation of gene expression by adenovirus transformation. (1995) (19)
- The effect of cell irradiation on mutation in ultraviolet-irradiated and intact simian virus 40. (1981) (19)
- Bloom's syndrome cells GM1492 lack detectable p53 protein but exhibit normal G1 cell-cycle arrest after UV irradiation. (1994) (18)
- Construction and characterization of an adenovirus type 5/adenovirus type 12 recombinant virus. (1983) (18)
- Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent. (1990) (18)
- Impaired recovery and mutagenic SOS-like responses in ataxia telangiectasia cells. (1989) (17)
- p53 shares an antigenic determinant with proteins of 92 and 150 kilodaltons that may be involved in senescence of human cells (1992) (17)
- Transfection of human lymphoblastoid cells with herpes simplex viral DNA. (1979) (15)
- Expression of avian leukaemia virus env-gp85 in Spodoptera frugiperda cells by use of a baculovirus expression vector. (1990) (15)
- Adenovirus E1A antagonizes both negative and positive growth signals elicited by transforming growth factor beta 1. (1995) (14)
- Absence of induction of enhanced reactivation of herpes simplex virus in cells from xeroderma pigmentosum patients without skin cancer. (1988) (14)
- Enhanced induction of SV40 replication from transformed rat cells by fusion with UV-irradiated normal and repair-deficient human fibroblasts. (1986) (13)
- Survival of UV-irradiated vaccinia virus in normal and xeroderma pigmentosum fibroblasts; evidence for repair of UV-damaged viral DNA. (1994) (13)
- Co-regulated expression of junB and MHC class I genes in adenovirus-transformed cells. (1991) (13)
- GM1492 human diploid skin fibroblasts lack the p53-dependent G1 cell-cycle checkpoint. (1995) (13)
- Induction of the mitogen-activated p70 S6 kinase by adenovirus E1A. (1995) (12)
- Site of proline hydroxylation during collagen synthesis in mouse fibroblasts. (1970) (12)
- Expression, purification, and functional characterization of adenovirus 5 and 12 E1A proteins produced in insect cells. (1992) (12)
- Altered phosphorylation and oligomerization of p53 in adenovirus type 12-transformed cells. (1995) (11)
- Tumor- and growth-related membrane changes caused by transformation with different fragments of the adenovirus 12 genome. (1982) (11)
- Immunosurveillance of virus-induced tumors. (1989) (11)
- Down-regulation of T-STAR, a growth inhibitory protein, after SV40-mediated immortalization. (2001) (11)
- Enhanced induction of SV40 replication from transformed mammalian cells by fusion with UV-irradiated untransformed cells. (1985) (10)
- A lack of radiation-induced ornithine decarboxylase activity prevents enhanced reactivation of herpes simplex virus and is linked to non-cancer proneness in xeroderma pigmentosum patients. (1997) (10)
- Cells transformed by adenovirus type 12 but not by type 5 are dependent on insulin or insulin-like growth factor I for their proliferation. (1988) (9)
- Adenosine deaminase gene expression is regulated posttranscriptionally in the nucleus. (1988) (9)
- Analysis of virus-specific mRNAs present in cells transformed with restriction fragments of adenovirus type 5 DNA. (1983) (9)
- Inheritance of abnormal expression of SOS-like response in xeroderma pigmentosum and hereditary cancer-prone syndromes. (1996) (9)
- Differentially expressed transcripts in x‐ray induced lymphomas identified by dioxygenin‐labeled differential display (1999) (8)
- Transcription of the transforming region of adenovirus type 5 in a rat cell line transformed by a small restriction fragment (1978) (8)
- Apoptin-induced apoptosis: potential for antitumor therapy. (1998) (7)
- Mutagenesis in UV-irradiated simian virus 40 occurs predominantly at pyrimidine doublets. (1985) (7)
- Towards integrating vectors for gene therapy: expression of functional bacteriophage MuA and MuB proteins in mammalian cells. (2000) (6)
- Insertion of the human cytomegalovirus enhancer into a myeloproliferative sarcoma virus long terminal repeat creates a high-expression retroviral vector. (1994) (6)
- Temperature-sensitive mutant p53 (ala143) interferes transiently with DNA-synthesis and cell-cycle progression in Saos-2 cells. (1996) (6)
- Homologous recombination is not enhanced in UV-irradiated normal and repair-deficient human fibroblasts. (1989) (6)
- Differential effect of ultraviolet light on the induction of simian virus 40 and a cellular mutator phenotype in transformed mammalian cells. (1985) (6)
- Side effects of suicide gene therapy. (2004) (6)
- Transforming properties of a 15-kDa truncated Ad12 E1A gene product. (1986) (5)
- Repression of cyclin D1 expression does not contribute to initiation or maintenance of cell transformation by adenovirus type 5 E1 (1996) (4)
- Adenosine deaminase mRNA expression is regulated posttranscriptionally during differentiation of HL-60 cells. (1987) (4)
- Suppression of cellular gene activity in adenovirus-transformed cells. (1989) (3)
- Factors impeding efficient expression of factor VIII complementary DNA minigenes. (1997) (3)
- Abnormal kinetics of induction of UV-stimulated recombination in human DNA repair disorders. (2003) (2)
- Different adenovirus E1A-controlled properties of transformed cells require different levels of E1A expression. (1987) (2)
- [Changes in the composition of transcription factor AP-1 in rat embryonal fibroblast cells, transformed by E1A and Ha-Ras oncogenes]. (1999) (2)
- [Cells of patients with ataxia telangiectasia show a normal capacity of radio-induced reactivation of damaged HSV-1 virus]. (1987) (1)
- How to deal with potential contaminations of monoclonal antibody preparations. (1990) (1)
- Induction of differentiation-regulated transcription factor Oct-6 specifically accompanies major histocompatibility complex class I down-regulation by E1A of oncogenic adenovirus type 12. (1995) (1)
- The role of oncogenes in the pathogenesis of cancer. (1986) (0)
- Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells (1985) (0)
- Dominant and recessive oncogenes in carcinogenesis. (1988) (0)
- Unusual Interactions of Adenovirus 5 and 12 E1B Proteins with p53 (1993) (0)
- Response to apoptin of diploid fibroblasts from cancer-prone syndromes. (2001) (0)
- Transformation by DNA viral oncogenes. (2001) (0)
- Oncogenes and malignant transformation. (1986) (0)
- Induction of polyploidy in adenovirus E1-transformed cells by the mitotic inhibitor colcemid. (1996) (0)
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