Allen M. Spiegel
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(Suggest an Edit or Addition)Allen M. Spiegel's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Positional cloning of the gene for multiple endocrine neoplasia-type 1. (1997) (1906)
- Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. (1991) (1502)
- Menin Interacts with the AP1 Transcription Factor JunD and Represses JunD-Activated Transcription (1999) (627)
- Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states. (1997) (461)
- Menin, the product of the MEN1 gene, is a nuclear protein. (1998) (435)
- A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. (2001) (434)
- The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family. (1991) (334)
- Receptor-effector coupling by G proteins: implications for normal and abnormal signal transduction. (1992) (327)
- Human cDNA clones for four species of G alpha s signal transduction protein. (1986) (318)
- Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas. (1997) (305)
- Severe endocrine and nonendocrine manifestations of the McCune-Albright syndrome associated with activating mutations of stimulatory G protein GS. (1993) (292)
- Resistance to multiple hormones in patients with pseudohypoparathyroidism. Association with deficient activity of guanine nucleotide regulatory protein. (1983) (287)
- Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain. (1987) (283)
- Signal transduction by guanine nucleotide binding proteins (1987) (283)
- Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1. (1997) (281)
- Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies. (1989) (280)
- The histopathology of fibrous dysplasia of bone in patients with activating mutations of the Gsα gene: site‐specific patterns and recurrent histological hallmarks (1999) (249)
- Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis. (1990) (246)
- Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung. (1997) (238)
- Deficient activity of guanine nucleotide regulatory protein in erythrocytes from patients with pseudohypoparathyroidism. (1980) (237)
- Mutations of the MEN1 tumor suppressor gene in pituitary tumors. (1997) (235)
- Inherited diseases involving g proteins and g protein-coupled receptors. (2004) (233)
- A prospective trial evaluating a standard approach to reoperation for missed parathyroid adenoma. (1996) (232)
- Mutations of the GNAS1 Gene, Stromal Cell Dysfunction, and Osteomalacic Changes in Non–McCune–Albright Fibrous Dysplasia of Bone (2000) (231)
- Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout (2003) (229)
- Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation. (1997) (228)
- Defects in G protein-coupled signal transduction in human disease. (1996) (227)
- The tumor suppressor protein menin interacts with NF-κB proteins and inhibits NF-κB-mediated transactivation (2001) (223)
- An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome. (1994) (222)
- Genome-Wide Analysis of Menin Binding Provides Insights into MEN1 Tumorigenesis (2006) (211)
- Reproduction of human fibrous dysplasia of bone in immunocompromised mice by transplanted mosaics of normal and Gsalpha-mutated skeletal progenitor cells. (1998) (208)
- Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes (1987) (202)
- Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation. (1994) (192)
- Urinary calcium excretion in familial hypocalciuric hypercalcemia. Persistence of relative hypocalciuria after induction of hypoparathyroidism. (1983) (188)
- Multiple endocrine neoplasia type 1: new clinical and basic findings (2001) (187)
- Identification of the Cysteine Residues in the Amino-terminal Extracellular Domain of the Human Ca2+ Receptor Critical for Dimerization (1999) (186)
- Treatment of hypercalcemia secondary to parathyroid carcinoma with a novel calcimimetic agent. (1998) (176)
- Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias. (1999) (171)
- An association between neonatal severe primary hyperparathyroidism and familial hypocalciuric hypercalcemia in three kindreds. (1982) (170)
- G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain. (1991) (169)
- Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment. (1990) (165)
- Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors. (1997) (165)
- Increased palmitoylation of the Gs protein alpha subunit after activation by the beta-adrenergic receptor or cholera toxin. (1993) (159)
- Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. (1985) (158)
- Receptor and effector interactions of Gs Functional studies with antibodies to the αs carboxyl‐terminal decapeptide (1989) (156)
- Mutations in G proteins and G protein-coupled receptors in endocrine disease. (1996) (154)
- Identification of the Sites of N-Linked Glycosylation on the Human Calcium Receptor and Assessment of Their Role in Cell Surface Expression and Signal Transduction* (1998) (152)
- Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. (1986) (151)
- Calcium-regulated parathyroid hormone release in primary hyperparathyroidism: studies in vitro with dispersed parathyroid cells. (1979) (150)
- Molecular Pathology of the MEN1 Gene (2004) (148)
- Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system. (1990) (139)
- Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients. (1996) (137)
- Hyperparathyroidism in hereditary syndromes: special expressions and special managements. (2002) (133)
- Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter (2003) (130)
- Activity of the stimulatory guanine nucleotide-binding protein is reduced in erythrocytes from patients with pseudohypoparathyroidism and pseudopseudohypoparathyroidism: biochemical, endocrine, and genetic analysis of Albright's hereditary osteodystrophy in six kindreds. (1986) (129)
- Menin molecular interactions: insights into normal functions and tumorigenesis. (2005) (129)
- Identification of the GTP-binding protein encoded by Gi3 complementary DNA. (1988) (129)
- The 32-Kilodalton Subunit of Replication Protein A Interacts with Menin, the Product of the MEN1 Tumor Suppressor Gene (2003) (128)
- Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators (2007) (128)
- Kinetic analysis of the rapid intraoperative parathyroid hormone assay in patients during operation for hyperparathyroidism. (1999) (128)
- Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go. (1988) (127)
- Abnormalities in G protein-coupled signal transduction pathways in human disease. (1993) (127)
- The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein. (1987) (127)
- Divalent cation metabolism. Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. (1978) (126)
- Parathyroid mitogenic activity in plasma from patients with familial multiple endocrine neoplasia type 1. (1986) (126)
- A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (1997) (126)
- Loss of heterozygosity at 11q13: analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects with familial multiple endocrine neoplasia type 1. (1997) (126)
- Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain. (1986) (125)
- Antisera against a guanine nucleotide binding protein from retina cross-react with the beta subunit of the adenylyl cyclase-associated guanine nucleotide binding proteins, Ns and Ni. (1985) (124)
- Dispersed cells prepared from human parathyroid glands: distinct calcium sensitivity of adenomas vs. primary hyperplasia. (1978) (124)
- The Carboxyl Terminus of the Human Calcium Receptor (1997) (122)
- A familial syndrome of decrease in sensitivity to 1,25-dihydroxyvitamin D. (1978) (121)
- Familial hypocalciuric hypercalcemia: recognition among patients referred after unsuccessful parathyroid exploration. (1980) (121)
- Common ancestral mutations in the MEN1 gene is likely responsible for the prolactinoma variant of MEN1 (MEN1Burin) in four kindreds from Newfoundland (1998) (121)
- Clinical implications of guanine nucleotide-binding proteins as receptor-effector couplers. (1985) (120)
- Localization of parathyroid adenomas in patients who have undergone surgery. Part I. Noninvasive imaging methods. (1987) (119)
- Receptor-effector coupling by G proteins (1990) (118)
- The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. (2001) (117)
- Family studies in patients with primary parathyroid hyperplasia. (1977) (115)
- Fluoride stimulation of adenylate cyclase is dependent on the guanine nucleotide regulatory protein. (1980) (115)
- Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor. (2007) (113)
- Maximal urine-concentrating ability: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. (1981) (113)
- Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils. (1986) (110)
- Stable overexpression of MEN1 suppresses tumorigenicity of RAS (1999) (109)
- Naturally occurring mutations of the extracellular Ca2+-sensing receptor: implications for its structure and function (2003) (108)
- Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells. (1991) (108)
- Allelic loss from chromosome 11 in parathyroid tumors. (1992) (107)
- Bidirectional transcriptional activity of PGK‐neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice (2001) (106)
- Guanine nucleotides: key regulators of hormone receptor-adenylate cyclase interaction. (1981) (106)
- MEN1 gene analysis in sporadic adrenocortical neoplasms. (1999) (105)
- Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C. (1986) (104)
- Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2 (1993) (104)
- A heterozygous 4-bp deletion mutation in the Gs alpha gene (GNAS1) in a patient with Albright hereditary osteodystrophy. (1992) (104)
- Genotype/phenotype correlation of multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas. (2000) (101)
- Palmitoylation of a G protein alpha i subunit requires membrane localization not myristoylation. (1994) (101)
- Sporadic hypoparathyroidism caused by de Novo gain-of-function mutations of the Ca(2+)-sensing receptor. (1997) (100)
- alpha-Transducin immunoreactivity in retinae and sensory pineal organs of adult vertebrates. (1986) (98)
- Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism. (2003) (98)
- Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937. (1989) (97)
- Familial hypocalciuric hypercalcemia: the relation to primary parathyroid hyperplasia. (1982) (97)
- Mutational analysis of the cysteines in the extracellular domain of the human Ca2+ receptor: effects on cell surface expression, dimerization and signal transduction (1998) (96)
- The G protein connection: molecular basis of membrane association. (1991) (94)
- Human Ca2+ Receptor Cysteine-rich Domain (2000) (93)
- The G protein alpha s subunit incorporates [3H]palmitic acid and mutation of cysteine-3 prevents this modification. (1993) (93)
- G proteins couple alpha-adrenergic and GABAb receptors to inhibition of peptide secretion from peripheral sensory neurons (1989) (91)
- Identification of Acidic Residues in the Extracellular Loops of the Seven-transmembrane Domain of the Human Ca2+ Receptor Critical for Response to Ca2+ and a Positive Allosteric Modulator* (2002) (89)
- Aspiration of enlarged parathyroid glands for parathyroid hormone assay. (1983) (89)
- Purification and immunochemical characterization of the major pertussis-toxin-sensitive guanine-nucleotide-binding protein of bovine-neutrophil membranes. (1987) (89)
- A Region in the Seven-transmembrane Domain of the Human Ca2+ Receptor Critical for Response to Ca2+* (2005) (86)
- The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations. (2007) (84)
- Effects of a calcimimetic compound and naturally activating mutations on the human Ca2+ receptor and on Ca2+ receptor/metabotropic glutamate chimeric receptors. (2000) (83)
- Deficient guanine nucleotide regulatory unit activity in cultured fibroblast membranes from patients with pseudohypoparathyroidism type I. a cause of impaired synthesis of 3',5'-cyclic AMP by intact and broken cells. (1983) (80)
- MEN1 gene mutation analysis of high‐grade neuroendocrine lung carcinoma (2000) (79)
- Development of opiate receptors and GTP-binding regulatory proteins in neonatal rat brain. (1987) (78)
- Genetic abnormalities in sporadic parathyroid adenomas. (1990) (78)
- Binding of 5'-guanylyl-imidodiphosphate to turkey erythrocyte membranes and effects on beta-adrenergic-activated adenylate cyclase. (1974) (78)
- Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein. (1991) (77)
- Neonatal primary hyperparathyroidism with autosomal dominant inheritance. (1977) (77)
- Technetium-99m-sestamibi imaging before reoperation for primary hyperparathyroidism. (1995) (77)
- Genetic mapping of the Gs-alpha subunit gene (GNAS1) to the distal long arm of chromosome 20 using a polymorphism detected by denaturing gradient gel electrophoresis. (1991) (74)
- Direct comparison in vivo and in vitro of suppressibility of parathyroid function by calcium in primary hyperparathyroidism. (1979) (74)
- N-linked glycosylation of the human Ca2+ receptor is essential for its expression at the cell surface. (1997) (74)
- Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes. (1996) (73)
- Reoperative parathyroid surgery for persistent hyperparathyroidism. (1978) (71)
- Evidence for direct interaction of Gs alpha with the Ca2+ channel of skeletal muscle. (1991) (71)
- Human cDNA clones for an alpha subunit of Gi signal-transduction protein. (1987) (70)
- Reduced expression of multiple forms of the alpha subunit of the stimulatory GTP-binding protein in pseudohypoparathyroidism type Ia. (1987) (70)
- Immunological and molecular characterization of Go alpha-like proteins in the Drosophila central nervous system. (1989) (70)
- Results of a multidisciplinary strategy for management of mediastinal parathyroid adenoma as a cause of persistent primary hyperparathyroidism. (1992) (70)
- Functional characterization of five V2 vasopressin receptor gene mutations (1996) (69)
- Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain. (1985) (68)
- Detection of multiple forms of Giα in HL60 cells (1987) (67)
- Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis. (1997) (65)
- Osteoblastic cells derived fronm isolated lesions of fibrous dysplasia contain activating somatic mutatuions of thje Gsα gene (1995) (65)
- Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1. (2009) (65)
- Heterogeneous size of the parathyroid glands in familial multiple endocrine neoplasia type 1 (1991) (64)
- Expression, Purification, and Biochemical Characterization of the Amino-terminal Extracellular Domain of the Human Calcium Receptor* (1999) (64)
- The molecular basis of disorders caused by defects in G proteins. (1997) (63)
- G Proteins, Receptors, and Disease (1998) (62)
- Olfactory dysfunction in humans with deficient guanine nucleotide-binding protein (1986) (62)
- Subcellular localization of Gi alpha in human neutrophils. (1988) (61)
- Immunolocalization of G protein alpha-subunits in the Drosophila CNS (1990) (61)
- Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region (1997) (60)
- Prospective evaluation of selective venous sampling for parathyroid hormone concentration in patients undergoing reoperations for primary hyperparathyroidism. (1993) (59)
- Results of reoperation for persistent and recurrent hyperparathyroidism. (1981) (59)
- The GTP-binding regulatory proteins of neuroblastoma x glioma, NG108-15, and glioma, C6, cells. Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No. (1986) (59)
- Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein. (1987) (57)
- Identification and persistence of beta adrenergic receptors during maturation of the rat reticulocyte. (1977) (57)
- The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1) (2015) (57)
- Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1 (2004) (57)
- Multiple endocrine neoplasia type 1: atypical presentation, clinical course, and genetic analysis of multiple tumors. (1999) (56)
- Localization of parathyroid adenomas in patients who have undergone surgery. Part II. Invasive procedures. (1987) (56)
- Pheromone action regulates G-protein alpha-subunit myristoylation in the yeast Saccharomyces cerevisiae. (1993) (55)
- An antibody directed against the carboxyl-terminal decapeptide of the alpha subunit of the retinal GTP-binding protein, transducin. Effects on transducin function. (1988) (53)
- Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation. (2007) (53)
- Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system. (1986) (52)
- Autotransplantation of Cryopreserved Parathyroid Tissue in Man (1979) (52)
- Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates. (1988) (52)
- Circulating parathyroid hormone activity: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. (1978) (52)
- Executive summary of the Strategic Plan for National Institutes of Health Obesity Research. (2005) (51)
- Characterization of the dopamine-responsive adenylate cyclase of bovine parathyroid cells and its relationship to parathyroid hormone secretion. (1980) (51)
- Chemically induced hypothyroidism produces elevated amounts of the alpha subunit of the inhibitory guanine nucleotide binding protein (Gi) and the beta subunit common to all G-proteins. (1987) (50)
- Parathyroid adenomas in the aortopulmonary window. (1996) (50)
- Insulin-like growth factor I receptors in retinal rod outer segments. (1987) (50)
- Deficient adenylate cyclase regulatory protein in renal membranes from a patient with pseudohypoparathyroidism. (1983) (50)
- Signal transduction by guanine nucleotide-binding proteins. (1988) (49)
- Selective deficiency of guanine nucleotide-binding protein Go in two dopamine-resistant pituitary tumors. (1988) (48)
- Inhibition of DNA synthesis in living cells by microinjection of Gi2 antibodies. (1992) (47)
- Localization and operative management of undescended parathyroid adenomas in patients with persistent primary hyperparathyroidism. (1994) (47)
- Monoclonal Antibodies Against Synthetic Peptides Corresponding to the Extracellular Domain of the Human Ca2+ Receptor: Characterization and Use in Studying Concanavalin A Inhibition (1997) (47)
- Assessment of techniques for preoperative parathyroid gland localization in patients undergoing reoperation for hyperparathyroidism. (1982) (47)
- Angiographic ablation of parathyroid adenomas: lessons from a 10-year experience. (1987) (46)
- Recurrent hyperparathyroidism from an autotransplanted parathyroid adenoma. (1978) (46)
- G Protein Defects in Signal Transduction (2000) (46)
- Expression of the calcium-sensing receptor in gastrinomas. (2000) (45)
- Detection of alpha-transducin in retinal rods but not cones. (1986) (45)
- A Missense Mutation in the Seven-transmembrane Domain of the Human Ca2+ Receptor Converts a Negative Allosteric Modulator into a Positive Allosteric Modulator* (2006) (44)
- Characterization of a MEN1 ortholog from Drosophila melanogaster. (2001) (44)
- A 2.8-Mb clone contig of the multiple endocrine neoplasia type 1 (MEN1) region at 11q13. (1997) (44)
- Human Ca(2+) receptor extracellular domain. Analysis of function of lobe I loop deletion mutants. (2001) (42)
- Analysis of recurrent germline mutations in the MEN1 gene encountered in apparently unrelated families (1998) (42)
- Deferred parathyroid autografts with cryopreserved tissue after reoperative parathyroid surgery. (1982) (41)
- Angiographic ablation of parathyroid adenomas. (1979) (40)
- Use of preoperative fine-needle aspiration in patients undergoing reoperation for primary hyperparathyroidism. (1994) (39)
- Treatment of hyperparathyroidism by percutaneous embolization of a mediastinal adenoma. (1975) (39)
- Expression of G protein alpha-subunits in bovine parathyroid. (1995) (39)
- Tissue-specific regulation of GTP-binding protein and muscarinic acetylcholine receptor levels during cardiac development. (1987) (39)
- Identification of G Protein α-Subunits in RINm5F Cells and Their Selective Interaction with Galanin Receptor (1991) (39)
- Isolation, characterization, expression and functional analysis of the zebrafish ortholog of MEN1 (2000) (38)
- G proteins in cellular control (1992) (37)
- Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene. (1997) (37)
- Locally recurrent parathyroid neoplasms as a cause for recurrent and persistent primary hyperparathyroidism. (1991) (36)
- Inhibition of thyrotropin-induced DNA synthesis in thyroid follicular cells by microinjection of an antibody to the stimulatory G protein of adenylate cyclase, Gs. (1992) (36)
- Deficiency of hormone receptor-adenylate cyclase coupling protein: basis for hormone resistance in pseudohypoparathyroidism. (1982) (36)
- Parathyroid tumor development involves deregulation of homeobox genes. (2008) (35)
- The gene for multiple endocrine neoplasia type 1: recent findings. (1999) (35)
- GTP-binding proteins in brain and neutrophil are tethered to the plasma membrane via their amino termini. (1987) (35)
- G proteins in clinical medicine. (1988) (34)
- Identification and characterization of JunD missense mutants that lack menin binding (2000) (33)
- The localization of abnormal mediastinal parathyroid glands. (1975) (33)
- Carboxyl methylation and COOH-terminal processing of the brain G-protein gamma-subunit. (1990) (33)
- Hyperparathyroidism--a reversible cause of cimetidine-resistant gastric hypersecretion. (1979) (33)
- Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems. (1985) (33)
- Albright's hereditary osteodystrophy and defective G proteins. (1990) (32)
- Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders* (2016) (32)
- Human chorionic gonadotropin subunit measurement in primary hyperparathyroidism. (1982) (31)
- Vanadate stimulates adenylate cyclase via the guanine nucleotide regulatory protein by a mechanism differing from that of fluoride. (1982) (31)
- Heterogeneous gland size in sporadic multiple gland parathyroid hyperplasia. (1999) (30)
- Mutations of the Gs a-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis (29)
- Beta-adrenergic receptors, cyclic AMP, and ion transport in the avian erythrocyte. (1975) (29)
- Obesity on the brain (2005) (29)
- The role of guanyl nucleotides in the expression on of catecholamine-responsive adenylate cyclase during maturation of the rat reticulocyte. (1977) (29)
- Osteoblastic cells derived from isolated lesions of fibrous dysplasia contain activating somatic mutations of the Gs alpha gene. (1995) (29)
- Molecular Cloning of Human Gαq cDNA and Chromosomal Localization of the Gαq Gene (GNAQ) and a Processed Pseudogene (1995) (29)
- In vitro and in vivo growth inhibition of murine melanoma K-1735 cell by a dominant negative mutant alpha subunit of the Gi2 protein. (1996) (28)
- The detection of mediastinal parathyroid glands by computed tomography, selective arteriography, and venous sampling: an analysis of 17 cases. (1981) (28)
- Adenosine 3',5'-monophosphate response to parathyroid hormone: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. (1980) (28)
- Undescended parathyroid adenoma: An important etiology for failed operations for primary hyperparathyroidism (1990) (28)
- Intrathyroidal parathyroid adenoma or hyperplasia. An occasionally overlooked cause of surgical failure in primary hyperparathyroidism. (1975) (28)
- Differential expression of low molecular weight form of Gs-α in neostriatum and cerebellum: correlation with expression of calmodulin-independent adenylyl cyclase (1990) (27)
- Novel mutations in the V2 vasopressin receptor gene of patients with X-linked nephrogenic diabetes insipidus. (1994) (27)
- GTP analogues promote release of the alpha subunit of the guanine nucleotide binding protein, Gi2, from membranes of rat glioma C6 BU1 cells. (1988) (27)
- Lithium does not inhibit the parathyroid hormone-mediated rise in urinary cyclic AMP and phosphate in humans. (1976) (27)
- Hyperfunctioning cystic parathyroid glands: CT and sonographic findings. (1984) (26)
- Diagnosis of radiosensitive hypothalamic tumors without craniotomy: endocrine and neuroradiologic studies of intracranial atypical teratomas. (1976) (26)
- Human parathyroid autografts: comparison of function in vivo and in vitro. (1979) (26)
- Site-specific antibodies directed against G protein beta and gamma subunits: effects on alpha and beta gamma subunit interaction. (1992) (26)
- Immunochemical and electrophoretic characterization of the major pertussis toxin substrate of the RAW264 macrophage cell line. (1988) (26)
- Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene (1999) (24)
- Intraoperative measurements of urinary cyclic AMP to guide surgery for primary hyperparathyroidism. (1980) (24)
- Pancreatic Insulinomas in Multiple Endocrine Neoplasia, Type I Knockout Mice Can Develop in the Absence of Chromosome Instability or Microsatellite Instability (2004) (24)
- The effect of short term lithium administration on suppressibility of parathyroid hormone secretion by calcium in vivo. (1984) (24)
- Myristoylation of an inhibitory GTP-binding protein a subunit is essential for its membrane attachment ( site-directed mutagenesis / immunoprecipitation / signal transduction / P 8-y subunits ) (24)
- Immunoelectron microscopic localization of photoreceptor-specific markers in the monkey retina. (1987) (23)
- Down-regulation of parathyroid (PTH)/PTH-related peptide receptor immunoreactivity and PTH binding in opossum kidney cells by PTH and dexamethasone. (1994) (23)
- Antibodies against synthetic peptides as probes of G protein structure and function. (1990) (23)
- Urinary cAMP excretion during surgery: an index of successful parathyroidectomy in patients with primary hyperparathyroidism. (1978) (23)
- Hypercalcemia with suppressed parathyroid hormone in Burkitt's lymphoma. (1978) (22)
- Receptor function and ion transport in turkey erythrocytes. (1976) (22)
- Protein kinase C-mediated phosphorylation of retinal rod outer segment membrane proteins. (1989) (22)
- CLINICAL ENDOCRINOLOGY & METABOLISM (1992) (21)
- Regulation of guanine nucleotide binding regulatory proteins in cultured adrenal cells by adrenocorticotropin and angiotensin-II. (1991) (21)
- 'Personalized medicine' to identify genetic risks for type 2 diabetes and focus prevention: can it fulfill its promise? (2012) (21)
- Pseudohypoparathyroidism: the molecular basis for hormone resistance--a retrospective. (1982) (20)
- Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism. (1984) (20)
- Differential diagnosis of brown tumor vs. cystic osteitis by arteriography and computed tomography. (1979) (20)
- The role of thyroid resection during reoperation for persistent or recurrent hyperparathyroidism. (1997) (20)
- Differential distribution of signal-transducing G-proteins in retina (1987) (20)
- Introduction to G-Protein-Coupled Signal Transduction and Human Disease (1998) (20)
- Effects of chemical and enzymatic modifications of glucagon on its activation of hepatic adenyl cyclase. (1969) (19)
- Isoprenylation of an inhibitory G protein alpha subunit occurs only upon mutagenesis of the carboxyl terminus. (1990) (19)
- Inborn errors of signal transduction: Mutations in G proteins and G protein-coupled receptors as a cause of disease (1997) (19)
- Immunoprecipitation of adenylate cyclase with an antibody to a carboxyl-terminal peptide from Gs alpha. (1990) (18)
- Antiserum raised against residues 159-168 of the guanine nucleotide-binding protein Gi3-alpha reacts with ependymal cells and some neurons in the rat brain containing cholecystokinin- or cholecystokinin- and tyrosine 3-hydroxylase-like immunoreactivities. (1988) (18)
- β-Arrestin--Not Just for G Protein-Coupled Receptors (2003) (18)
- Amino- and carboxy-terminal deletion mutants of Gs alpha are localized to the particulate fraction of transfected COS cells (1992) (17)
- Expression of GTP-binding proteins and prostaglandin E2 receptors during human T cell activation. (1991) (17)
- Parathyroid adenoma within the vagus nerve. (1994) (17)
- High level expression of transfected G protein αi3 subunit is required for plasma membrane targeting and adenylyl cyclase inhibition in NIH 3T3 fibroblasts (1992) (17)
- Computerized technetium/thallium scans and parathyroid reoperation. (1985) (17)
- Intraoperative ultrasound and reoperative parathyroid surgery: An initial evaluation (1986) (17)
- Parathymic parathyroid: CT, US, and angiographic findings. (1985) (16)
- Hormone resistance caused by mutations in G proteins and G protein-coupled receptors. (1999) (16)
- The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism. (1985) (16)
- Receptor-effector coupling by G-proteins implications for endocrinology (1989) (16)
- Radiographic findings in recurrent parathyroid carcinoma. (1982) (16)
- Functional interactions between the extracellular domain and the seven-transmembrane domain in Ca2+ receptor activation (2000) (15)
- Antibodies as probes of G-protein receptor-effector coupling and of G-protein membrane attachment. (1990) (15)
- Differential isoprenylation of carboxy-terminal mutants of an inhibitory G-protein alpha-subunit: neither farnesylation nor geranylgeranylation is sufficient for membrane attachment. (1992) (15)
- Separation of a guanine nucleotide regulatory unit from the adenylate cyclase complex with GTP affinity chromatography. (1979) (15)
- Immunochemical detection of guanine nucleotide binding proteins mono-ADP-ribosylated by bacterial toxins. (1986) (15)
- Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene. (1995) (14)
- Genetic interactions between Drosophila melanogaster menin and Jun/Fos. (2006) (14)
- CHAPTER 6 – Immunologic Probes for Heterotrimeric GTP-Binding Proteins (1990) (14)
- Mitogenic effects of pertussis toxin-sensitive G-protein α subunits: The mitogenic action of αi2 in NIH 3T3 cells is mimicked by αi1, but not αi3 (1993) (14)
- Effects of parathormone and lithium treatment on calcium and mood in depressed patients. (1977) (14)
- Membrane attachment of recombinant G-protein α-subunits in excess of βγ subunits in a eukaryotic expression system (1989) (13)
- Guanosine 5′, α-β-methylene, triphosphate, a novel GTP analog, causes persistent activation of adenylate cyclase: Evidence against pyrophosphorylation mechanism (1977) (13)
- Work in progress: abnormal parathyroid glands. Comparison of nonselective arterial digital arteriography, selective parathyroid arteriography, and venous digital arteriography as methods of detection. (1983) (13)
- Production and purification of human menin from Drosophila melanogaster S2 cells using stirred tank reactor (2001) (13)
- Gland Size Is Associated With Changes in Gene Expression Profiles in Sporadic Parathyroid Adenomas (2004) (13)
- 11q13 allelotype analysis in 27 northern American MEN1 kindreds identifies two distinct founder chromosomes. (1998) (13)
- High cervical intravagal hypercellular parathyroid gland as the etiology of severe persistent primary hyperparathyroidism. (1995) (12)
- The use of anti-peptide antisera to probe interactions between receptors and guanine nucleotide binding proteins. (1988) (12)
- Prospective analysis of intraoperative and postoperative urinary cyclic adenosine 3',5'-monophosphate levels to predict outcome of patients undergoing reoperations for primary hyperparathyroidism. (1988) (12)
- The use of specific antibodies to identify and quantify guanine nucleotide-binding proteins. (1987) (12)
- Characterization of the Promoter of the Human Gi2 α-Subunit Gene (1990) (12)
- NIH research on obesity and type 2 diabetes: providing the scientific evidence base for actions to improve health (2006) (12)
- Restoration of guanine nucleotide- and fluoride-stimulated activity to an adenylate cyclase-deficient cell line with affinity-purified guanine nucleotide regulatory protein. (1980) (11)
- Guanine nucleotide binding proteins and signal transduction. (1988) (11)
- Endogenous substrates for cAMP-dependent phosphorylation in dispersed bovine parathyroid cells. (1982) (11)
- The use of high-resolution ultrasound to locate parathyroid tumors during reoperations for primary hyperparathyroidism (1987) (11)
- Parathyroid imaging after intraarterial injections of [75Se]selenomethionine. (1981) (10)
- Inherited endocrine diseases involving G proteins and G protein-coupled receptors. (2007) (10)
- Focus on hereditary endocrine neoplasia. (2004) (9)
- Hypocalcemic stimulation and nonselective venous sampling for localizing parathyroid adenomas: work in progress. (1998) (9)
- The role of guanine nucleotides in regulation of adenylate cyclase activity. (1981) (9)
- Embolization of a mediastinal parathyroid adenoma. (1974) (9)
- CHAPTER 5 – Mechanism of Action of Hormones That Act at the Cell Surface (2011) (9)
- Failure of ablation of a mediastinal parathyroid adenoma by repeated contrast staining. (1981) (8)
- Inhibition of adenylate cyclase by arsenite and cadmium: evidence for a vicinal dithiol requirement. (1976) (8)
- Detection of mediastinal parathyroid glands by nonselective digital arteriography. (1984) (8)
- Preoperative localization of abnormal parathyroid: neck massage versus arteriography and selective venous sampling. (1978) (8)
- Decreased insulin content and secretion in RIN 1046-38 cells overexpressing α2-Adrenergic receptorsreceptors (1997) (7)
- Erratum: Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi in diabetes (Nature (1987) 327, (229-232) (1987) (7)
- Cholera-toxin-dependent ADP-ribosylation of the adenylate cyclase regulatory protein in turkey erythrocyte membranes. (1981) (7)
- Ultrasonic parathyroid localisation in previously operated patients. (1984) (7)
- Cell signaling. beta-arrestin--not just for G protein-coupled receptors. (2003) (7)
- Identification of multiple Gi subtypes and a novel G protein in bovine kidney cortex. (1989) (7)
- Decreased insulin content and secretion in RIN 1046-38 cells overexpressing alpha 2-adrenergic receptors. (1997) (7)
- Holocatalytic state of adenylate cyclase in turkey erythrocyte membranes: formation with guanylylimidodiphosphate plus isoproterenol without effect on affinity of beta-receptor. (1976) (6)
- Management of primary parathyroid hyperplasia. (1976) (6)
- BRIEF REPORT The Parathyroid/Pituitary Variant of Multiple Endocrine Neoplasia Type 1 Usually Has Causes Other than p27 Kip1 Mutations (2007) (6)
- Direct Identification and Characterization of β-Adrenergic Receptors and Functional Relationship of Adenylyl Cyclase (1978) (6)
- Baculovirus Expression and Purification of a Soluble, Mutant G-Protein α Subunit (1993) (6)
- Gi 2 mediates a 2-adrenergic inhibition of adenylyl cyclase in platelet membranes : In situ identification with Ga C-terminal antibodies ( signal transduction / guanine nucleotide-binding proteins / receptors ) (6)
- Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi in diabetes (1987) (5)
- The stem cell wars: a dispatch from the front. (2013) (5)
- Discussion section I (1991) (5)
- G protein gene knockout hits the gut (1995) (5)
- Receptor-effector coupling by G-proteins: implications for neuronal plasticity. (1990) (5)
- Detection of multiple forms of Gi alpha in HL60 cells. (1987) (5)
- Chymotrypsin selectively decreases forskolin stimulation of adenylate cyclase. (1985) (5)
- Urinary cyclic 3',5'-adenosine monophosphate (cAMP): an index of the action of parathyroid hormone on the kidney. (1980) (5)
- Baculovirus expression and purification of a soluble, mutant G-protein alpha subunit. (1993) (4)
- Chapter 24. G-proteins as Receptor-Effector Couplers (1988) (4)
- ROLE OF G PROTEINS IN SIGNAL TRANSDUCTION (1992) (4)
- Parathyroid aspiration directed by angiography: an alternative to venous sampling. (1984) (4)
- Parathyroid gland morphology in nonparathyroid hormone-mediated hypercalcemia (1985) (4)
- Antibodies as Probes of G-Protein Structure and Function (1990) (4)
- Future diagnostic and therapeutic trends in endocrine cancers. (2010) (4)
- G proteins: from basic to clinical studies. (1993) (4)
- Inhibition of DNA Synthesis in Living Cells by Microinjection of (1992) (4)
- News From the NIH (2000) (4)
- The β subunit of the guanine nucleotide regulatory proteins: Identification of its location on two‐dimesional gels of brain tissue and its regional and subcellular distribution in brain (1986) (4)
- Immunochemical studies of the 36-kDa common beta subunit of guanine nucleotide-binding proteins: identification of a major epitope. (1988) (4)
- Scleral calcifications in hyperparathyroidism: demonstration by computed tomography. (1977) (4)
- Scleral Calcifications in Hyperparathyroidism: Demonstration by Computed Tomography (1977) (4)
- Targeted therapies: Good news for advanced-stage pancreatic neuroendocrine tumors (2011) (3)
- Commentary: new guidelines for NIH peer review: improving the system or undermining it? (2010) (3)
- Persistent hyperparathyroidism caused by incomplete parathyroid resection and a hyperfunctioning parathyroid autograft. (1983) (3)
- 12 Parathyroid hormone and vitamin D receptors (1983) (3)
- Mitogenic effects of pertussis toxin-sensitive G-protein alpha subunits: the mitogenic action of alpha i2 in NIH 3T3 cells is mimicked by alpha i1, but not alpha i3. (1993) (3)
- Gsα, Pseudohypoparathyroidism, Fibrous Dysplasia, and McCune–Albright Syndrome (2013) (3)
- Guanine Nucleotide‐Binding Stimulatory Protein (1987) (3)
- Characterization of the promoter of the human Gi2 alpha-subunit gene. (1990) (3)
- Biochemical and immunochemical localization of GTP-binding proteins in the rat ileal enterocyte. (1993) (3)
- Pheromone action regulates G-protein a-subunit myristoylation in the yeast Saccharomyces cerevisiae ( posttranslational modiflcation / mutants / adaptation ) (2005) (2)
- The membrane localization of the G protein alpha s subunit is not dependent on its TENIR sequence or effector domain. (1994) (2)
- Pseudohypoparathyroidism: deficiency of hormone receptor-adenylate cyclase coupling protein as a cause of hereditary hormone resistance. (1982) (2)
- THE JEREMIAH METZGER LECTURE: A BRIEF HISTORY OF EUGENICS IN AMERICA: IMPLICATIONS FOR MEDICINE IN THE 21ST CENTURY. (2019) (2)
- Human Ca2+ Receptor Extracellular Domain (2001) (2)
- Increased adrenergic receptor content in membranes of stress induced erythrocytes (1975) (2)
- Multiple Endocrine Neoplasia Type 1 : Clinical and Genetic Topics Moderator : (2009) (1)
- THE USE OF SPECIFIC ANTISERA TO STUDY THE DEVELOPMENTAL REGULATION OF GUANINE NUCLEOTIDE BINDING PROTEINS (1987) (1)
- Immunological Probes of the Structure, Function, and Expression of Heterotrimeric GTP-Binding Proteins (1992) (1)
- G proteins--the disease spectrum expands. (2013) (1)
- Gα s -Activating Mutations (1998) (1)
- The GTP‐binding regulatory proteins of neuroblastoma × glioma, NG108‐15, and glioma, C6, cells (2001) (1)
- Expression and functional characterization of five v2 vasopressin receptor gene mutations identified in families with x-linked nephrogenic diabetes insipidus (1996) (1)
- Purification of parathyroid hormone like bioactivity from the rice leydig tumor of fisher rats (1984) (1)
- Sulfonylureas Amplify Cyclic 3′, 5′ AMP Mediated Hormone Action (1970) (1)
- Guanine Nucleotide Regulatory Proteins in Inflammatory and Immune Responses (1988) (1)
- THE MCCUNE ALBRIGHT SYNDROME: A GENETICALLY DETERMINED SIGNAL TRANSDUCTION DISORDER (1993) (1)
- Antiserum raised against residues 159-168 of the guanine nucleotide-binding protein GM 3-a reacts with ependymal cells and some neurons in the rat brain containing cholecystokinin-or cholecystokinin-and tyrosine 3-hydroxylase-like immunoreactivities ( transduction / glial cells / dopamine / neuropep (1)
- High level expression of transfected G protein alpha i3 subunit is required for plasma membrane targeting and adenylyl cyclase inhibition in NIH 3T3 fibroblasts. (1992) (1)
- Membrane attachment of recombinant G-protein alpha-subunits in excess of beta gamma subunits in a eukaryotic expression system. (1989) (1)
- 3 Gas-Activating Mutations A Cause of Acromegaly, Thyroid Adenomas, Fibrous Dysplasia, and the McCune-Albright Syndrome (1998) (1)
- The G Protein Coupled to the Thromboxane Az Receptor in Human Platelets Is a Member of the Novel G , Family* (2001) (1)
- Stable changes in expression or activation of G protein alpha i or alpha q subunits affect the expression of both beta 1 and beta 2 subunits. (1993) (1)
- G‐protein‐mediated Signal Transduction and Human Disorders (2006) (1)
- Citation for the 1999 Monsanto Clinical Investigator Lecture Award of the Endocrine Society to Dr. Stephen J. Marx. (1999) (0)
- The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family. (1991) (0)
- Chymotrypsin selectively impairs forskolin stimulation of adenylate cyclase (1985) (0)
- A double negative: inhibition of hepatic Gi signaling improves glucose homeostasis. (2018) (0)
- Technetium-99m-SestamibiImaging before Reoperation for PrimaryHyperparathyroidism (1995) (0)
- Susceptibility of the beta subunit of guanine nucleotide binding coupling proteins (G) to proteolytic cleavage (1985) (0)
- Guanosine 5', alpha-beta-methylene, triphosphate, a novel GTP analog, causes persistent activation of adenylate cyclase: evidence against pyrophosphorylation mechanism. (1977) (0)
- Incidence of primary hyperparathyroidism. (1980) (0)
- Partnering and functioning of the MEN1 tumour suppressor gene (2004) (0)
- Contents (2020) (0)
- The calcilytic agent NPS2143 rectifies hypocalcaemia in a mouse model, Nuf, that is due to an activating calcium-sensing-receptor (CaSR) mutation: relevance to autosomal dominant hypocalcaemia with hypercalciuria (2008) (0)
- Erratum to J Intern Med 2004; 255: 692–730 (2004) (0)
- Diagnosis of Radiosensitive Hypothalamic Tumors Without Craniotomy (2020) (0)
- In memoriam Gerald D. Aurbach. (1992) (0)
- Methods in enzymology: Vol. 195, adenylyl cyclase, G proteins, and guanylyl cyclase. Edited by Roger A. Johnson and Jackie D. Corbin. Academic Press, San Diego, CA, 511 pp. $69.00 (1991) (0)
- Citation for the 1997 Gerald D. Aurbach Lecture Award of The Endocrine Society to Edward M. Brown. (1997) (0)
- G Protein-Regulated Signaling Dysfunction in Human Disease: A Personal Historical Perspective (2003) (0)
- GTPanalogues promote release ofthea subunit oftheguanine nucleotide binding protein, Gj2, frommembranes ofratglioma C6BUlcells (1988) (0)
- Parathyroid tumors in familial multiple endocrine neoplasia type 1: The role of direct acting oncogenes and tumor suppressor genes (1990) (0)
- The calcilytic NPS2143 rectifies the gain-of-function associated with G-protein [alpha] 11 mutations causing autosomal dominant hypocalcaemia type 2 (2014) (0)
- In memoriam Gerald D. Aurbach. (1992) (0)
- Albert Einstein College of Medicine. (2008) (0)
- Erratum: Identification of multiple G(i) subtypes and a novel G protein in bovine kidney cortex (Biochemical Pharmacology, Vol. 38 (1989) 4502-4505) (1990) (0)
- Mutational analysis of the carboxyl-terminal region of the human calcium-sensing receptor (1997) (0)
- Methods in Enzymology, Volume 237, Heterotrimeric G Proteins, edited by Ravi Iyengar, Academic Press, San Diego, 1994, 519 pp., $89.00. (1994) (0)
- Exaggerated cyclic AMP response to parathyroid hormone in familial hypocalciuric hypercalcemia (1979) (0)
- Parathyroid hormone and vitamin D receptors. (1983) (0)
- Results of Reoperation for No. 6 Persistent and Recurrent Hyperpara thyroidism (1981) (0)
- Gerald D. Aurbach, 1927-1991 (1993) (0)
- Following in the Footsteps of a “Neuroscience” Giant (2016) (0)
- Expression and function of the calcium sensing receptor (CaR) in gastrinomas (2000) (0)
- Gland size is associated with changes in gene expression profiles in sporadic parathyroid adenomas (2006) (0)
- List of Contributors and Discussants (1981) (0)
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