Alan Robert Lehmann
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Molecular Biology
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Biology
Alan Robert Lehmann's Degrees
- PhD Biochemistry University of California, Berkeley
- Masters Molecular Biology Stanford University
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(Suggest an Edit or Addition)Alan Robert Lehmann's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. (2004) (874)
- Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis (2005) (701)
- Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. (1994) (640)
- Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation. (1975) (631)
- Y-family DNA polymerases and their role in tolerance of cellular DNA damage (2012) (601)
- DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. (2003) (521)
- The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH (1995) (484)
- Failure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum. (1982) (451)
- DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes (2001) (449)
- Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice (2000) (442)
- Postreplication repair of DNA in ultraviolet-irradiated mammalian cells. (1972) (424)
- Translesion synthesis: Y-family polymerases and the polymerase switch. (2007) (407)
- Trading places: how do DNA polymerases switch during translesion DNA synthesis? (2005) (404)
- Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient (1999) (390)
- The xeroderma pigmentosum group D (XPD) gene: one gene, two functions, three diseases. (2001) (385)
- Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. (2010) (361)
- Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. (1996) (349)
- Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast. (1994) (346)
- Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells. (2001) (303)
- Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene. (1997) (270)
- Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents (1992) (265)
- Incidence of DNA repair deficiency disorders in western Europe: Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. (2008) (251)
- Structure and Mechanism of Human DNA Polymerase η (2010) (242)
- Nse2, a Component of the Smc5-6 Complex, Is a SUMO Ligase Required for the Response to DNA Damage (2005) (234)
- The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair (1995) (233)
- Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein. (2004) (223)
- A role for polymerase eta in the cellular tolerance to cisplatin-induced damage. (2005) (221)
- Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins. (1995) (218)
- Biological effects of ultraviolet radiation (1979) (213)
- Repair of ultraviolet light damage in a variety of human fibroblast cell strains. (1977) (207)
- Human disorders showing increased sensitivity to the induction of genetic damage. (1978) (204)
- A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy. (1998) (201)
- Xeroderma pigmentosum and related disorders: defects in DNA repair and transcription. (2001) (199)
- Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta. (1999) (196)
- Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome (2010) (193)
- DNA repair: from molecular mechanism to human disease. (2006) (187)
- Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells (2008) (186)
- Molecular and biochemical characterization of xrs mutants defective in Ku80 (1997) (185)
- Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes Cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia. (2013) (185)
- Gaps and forks in DNA replication: Rediscovering old models. (2006) (179)
- The Y-family DNA polymerase κ (pol κ) functions in mammalian nucleotide-excision repair (2006) (175)
- Three complementation groups in Cockayne syndrome. (1982) (170)
- Molecular analysis of mutations in DNA polymerase η in xeroderma pigmentosum-variant patients (2002) (167)
- Regulation of translesion synthesis DNA polymerase eta by monoubiquitination. (2010) (164)
- Splitting the ATM: distinct repair and checkpoint defects in ataxia-telangiectasia. (1998) (162)
- Cloning the RAD51 homologue of Schizosaccharomyces pombe. (1993) (162)
- Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair (2012) (162)
- Nucleotide excision repair and the link with transcription. (1995) (157)
- Molecular analysis of mutations in the CSB (ERCC6) gene in patients with Cockayne syndrome. (1998) (154)
- Replication of damaged DNA by translesion synthesis in human cells (2005) (152)
- Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage (1994) (151)
- Three unusual repair deficiencies associated with transcription factor BTF2(TFIIH): evidence for the existence of a transcription syndrome. (1994) (150)
- A comparison of the 8-azaguanine and ouabain-resistance systems for the selection of induced mutant Chinese hamster cells. (1975) (150)
- A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair protein (2000) (147)
- Effects of caffeine and theophylline on DNA synthesis in unirradiated and UV-irradiated mammalian cells. (1974) (146)
- Structure and mechanism of human DNA polymerase η (2011) (145)
- Postreplication repair and PCNA modification in Schizosaccharomyces pombe. (2006) (142)
- Localization of DNA polymerases η and ι to the replication machinery is tightly co‐ordinated in human cells (2002) (140)
- Role of poly(adenosine diphosphate ribose) in deoxyribonucleic acid repair in human fibroblasts. (1982) (136)
- Mutations in the XPC gene in families with xeroderma pigmentosum and consequences at the cell, protein, and transcript levels. (2000) (135)
- Xeroderma pigmentosum (2011) (134)
- Role of DNA Polymerase η in the UV Mutation Spectrum in Human Cells* (2003) (133)
- Abnormal kinetics of DNA synthesis in ultraviolet light-irradiated cells from patients with Cockayne's syndrome. (1979) (133)
- Double-strand breaks in the DNA of a mammalian cell after x-irradiation. (1970) (129)
- The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair. (2006) (129)
- Deep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defect (2016) (128)
- Mutations in the xeroderma pigmentosum group D DNA repair/transcription gene in patients with trichothiodystrophy (1994) (126)
- Ubiquitination of PCNA and the Polymerase Switch in Human Cells (2004) (124)
- Composition and Architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) Complex (2005) (120)
- Replication of damaged DNA in mammalian cells: new solutions to an old problem. (2002) (118)
- Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy. (2002) (116)
- Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome (2006) (114)
- Defects in the DNA repair and transcription gene ERCC2 in the cancer-prone disorder xeroderma pigmentosum group D. (1995) (113)
- Postreplication repair of DNA in mammalian cells. (1974) (113)
- The Smc5-Smc6 DNA Repair Complex (2006) (111)
- Defects in the DNA repair and transcription gene ERCC2(XPD) in trichothiodystrophy. (1996) (111)
- Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy. (2001) (110)
- A rapid non-radioactive technique for measurement of repair synthesis in primary human fibroblasts by incorporation of ethynyl deoxyuridine (EdU) (2008) (109)
- Genetic heterogeneity of the excision repair defect associated with trichothiodystrophy. (1993) (108)
- Neurological symptoms and natural course of xeroderma pigmentosum. (2008) (107)
- Translesion synthesis in mammalian cells. (2006) (106)
- Trichothiodystrophy, a human DNA repair disorder with heterogeneity in the cellular response to ultraviolet light. (1988) (106)
- The replication of DNA in murine lymphoma cells (L5178Y). I. Rate of replication. (1970) (105)
- Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells. (2007) (104)
- Immune function, mutant frequency, and cancer risk in the DNA repair defective genodermatoses xeroderma pigmentosum, Cockayne's syndrome, and trichothiodystrophy. (1990) (104)
- Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene. (2001) (103)
- The role of SMC proteins in the responses to DNA damage. (2005) (103)
- Growth retardation and immunodeficiency in a patient with mutations in the DNA ligase I gene (1992) (101)
- Characterization of the alternative excision repair pathway of UV-damaged DNA in Schizosaccharomyces pombe. (1997) (100)
- Analysis of mutations in the XPD gene in Italian patients with trichothiodystrophy: site of mutation correlates with repair deficiency, but gene dosage appears to determine clinical severity. (1998) (100)
- Transcription restores DNA repair to heterochromatin, determining regional mutation rates in cancer genomes. (2014) (93)
- Effect of caffeine on DNA synthesis in mammalian cells. (1972) (92)
- Identification of the Proteins, Including MAGEG1, That Make Up the Human SMC5-6 Protein Complex (2007) (89)
- The relationship between cell growth, macromolecular synthesis and poly ADP-ribose polymerase in lymphoid cells. (1974) (85)
- Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex. (2001) (85)
- Cockayne's syndrome: correlation of clinical features with cellular sensitivity of RNA synthesis to UV irradiation. (1993) (84)
- An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria. (2006) (84)
- Cloning and characterisation of the rad9 DNA repair gene from Schizosaccharomyces pombe (1991) (84)
- ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage (2011) (83)
- Effect of proliferating cell nuclear antigen ubiquitination and chromatin structure on the dynamic properties of the Y-family DNA polymerases. (2008) (82)
- Hypomorphic PCNA mutation underlies a human DNA repair disorder. (2014) (79)
- Proliferating Cell Nuclear Antigen-dependent Coordination of the Biological Functions of Human DNA Polymerase ι* (2004) (78)
- Impaired Translesion Synthesis in Xeroderma Pigmentosum Variant Extracts (1999) (78)
- A semi-automated non-radioactive system for measuring recovery of RNA synthesis and unscheduled DNA synthesis using ethynyluracil derivatives. (2010) (77)
- The response of ataxia telangiectasia cells to bleomycin. (1979) (76)
- Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. (2003) (76)
- A derivative of an ataxia-telangiectasia (A-T) cell line with normal radiosensitivity but A-T-like inhibition of DNA synthesis. (1986) (74)
- Relationship between pyrimidine dimers, 6-4 photoproducts, repair synthesis and cell survival: studies using cells from patients with trichothiodystrophy. (1990) (72)
- Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation (2011) (72)
- Prenatal diagnosis in a subset of trichothiodystrophy patients defective in DNA repair (1992) (71)
- Conservation of eukaryotic DNA repair mechanisms. (2001) (71)
- Evolutionary conservation of excision repair in Schizosaccharomyces pombe: evidence for a family of sequences related to the Saccharomyces cerevisiae RAD2 gene. (1993) (69)
- Five polymorphisms in the coding sequence of the xeroderma pigmentosum group D gene. (1996) (68)
- Cells from an immunodeficient patient (46BR) with a defect in DNA ligation are hypomutable but hypersensitive to the induction of sister chromatid exchanges. (1985) (68)
- Photocarcinogenesis and inhibition of intercellular adhesion molecule 1 expression in cells of DNA-repair-defective individuals. (1997) (67)
- Localisation of human Y-family DNA polymerase κ: relationship to PCNA foci (2005) (66)
- Cloning and characterization of the rad4 gene of Schizosaccharomyces pombe; a gene showing short regions of sequence similarity to the human XRCC1 gene. (1991) (66)
- A rapid procedure for measurement of DNA repair in human fibroblasts and for complementation analysis of xeroderma pigmentosum cells. (1980) (66)
- The release of high molecular weight DNA from a mammalian cell (L-5178Y). Attachment of the DNA to the nuclear membrane. (1971) (66)
- Studies on a new case of xeroderma pigmentosum (XP3BR) from complementation group G with cellular sensitivity to ionizing radiation. (1980) (66)
- Cloning and characterisation of the S. pombe rad15 gene, a homologue to the S. cerevisiae RAD3 and human ERCC2 genes. (1992) (64)
- Patients with xeroderma pigmentosum complementation groups C, E and V do not have abnormal sunburn reactions (2013) (63)
- USP7 is essential for maintaining Rad18 stability and DNA damage tolerance (2016) (62)
- UV damage causes uncontrolled DNA breakage in cells from patients with combined features of XP‐D and Cockayne syndrome (2000) (59)
- Genetic analysis of twenty-two patients with Cockayne syndrome (1996) (59)
- Identical mutations in the CSB gene associated with either Cockayne syndrome or the DeSanctis-cacchione variant of xeroderma pigmentosum. (2000) (57)
- A role for chromatin remodellers in replication of damaged DNA (2012) (57)
- Alterations in the CSB gene in three Italian patients with the severe form of Cockayne syndrome (CS) but without clinical photosensitivity. (1999) (57)
- Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA (2015) (57)
- Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease (2016) (56)
- DNA repair and cancer: speculations based on studies with xeroderma pigmentosum, Cockayne's syndrome and trichothiodystrophy. (1989) (56)
- Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families (2011) (56)
- Simultaneous Disruption of Two DNA Polymerases, Polη and Polζ, in Avian DT40 Cells Unmasks the Role of Polη in Cellular Response to Various DNA Lesions (2010) (56)
- DNA repair and ultraviolet mutagenesis in cells from a new patient with xeroderma pigmentosum group G and cockayne syndrome resemble xeroderma pigmentosum cells. (1996) (56)
- Post-replication repair of DNA in ultraviolet-irradiated mammalian cells. No gaps in DNA synthesized late after ultraviolet irradiation. (1972) (56)
- Mutant sequences in the rpsL gene of Escherichia coli B/r: Mechanistic implications for spontaneous and ultraviolet light mutagenesis (1992) (56)
- Replication of UV-damaged DNA: new insights into links between DNA polymerases, mutagenesis and human disease. (2000) (55)
- DNA polymerases and repair synthesis in NER in human cells. (2011) (55)
- Relation between the human fibroblast strain 46BR and cell lines representative of Bloom's syndrome. (1988) (54)
- Repair of cyclobutane pyrimidine dimers and 6‐4 photoproducts in the fission yeast Schizosaccharomyces pombe (1993) (54)
- Technologies for Detection of DNA Damage and Mutations (1997) (54)
- Specialized interfaces of Smc5/6 control hinge stability and DNA association (2017) (53)
- A biochemical defect in the repair of alkylated DNA in cells from an immunodeficient patient (46BR). (1983) (53)
- Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum. (2006) (51)
- Molecular analysis of ultraviolet-induced mutations in a xeroderma pigmentosum cell line. (1991) (51)
- Localisation of human Y-family DNA polymerase kappa: relationship to PCNA foci. (2005) (49)
- PRENATAL DIAGNOSIS OF COCKAYNE'S SYNDROME (1985) (48)
- Functional and clinical relevance of novel mutations in a large cohort of patients with Cockayne syndrome (2018) (48)
- Inhibition of DNA replication by ionizing radiation is mediated by a trans-acting factor. (1989) (48)
- The relationship between pyrimidine dimers and replicating DNA in UV-irradiated human fibroblasts. (1979) (48)
- New functions for Y family polymerases. (2006) (48)
- Inactivation of a transfected gene in human fibroblasts can occur by deletion, amplification, phenotypic switching, or methylation (1987) (48)
- Use of recombinant DNA techniques in cloning DNA repair genes and in the study of mutagenesis in mammalian cells. (1985) (47)
- Effect of DNA damage on the expression of the chloramphenicol acetyltransferase gene after transfection into diploid human fibroblasts. (1985) (47)
- The cancer-free phenotype in trichothiodystrophy is unrelated to its repair defect. (2000) (46)
- XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency. (2015) (45)
- SV 40-transformed normal and DNA-repair-deficient human fibroblasts can be transfected with high frequency but retain only limited amounts of integrated DNA. (1988) (45)
- Transcription-Associated Breaks in Xeroderma Pigmentosum Group D Cells from Patients with Combined Features of Xeroderma Pigmentosum and Cockayne Syndrome (2005) (44)
- Excision repair in Cockayne syndrome. (1982) (44)
- Cells from XP-D and XP-D-CS patients exhibit equally inefficient repair of UV-induced damage in transcribed genes but different capacity to recover UV-inhibited transcription. (1999) (43)
- The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ (2015) (43)
- Subchromosomal localization of a gene (XRCC5) involved in double strand break repair to the region 2q34-36 (1993) (43)
- Artefacts arising from the sedimentation of high molecular weight DNA on sucrose gradients. (1971) (42)
- Ubiquitination and deubiquitination of PCNA in response to stalling of the replication fork (2009) (42)
- Rad8Rad5/Mms2–Ubc13 ubiquitin ligase complex controls translesion synthesis in fission yeast (2010) (42)
- The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex (2015) (42)
- XPD structure reveals its secrets. (2008) (40)
- Ubiquitin‐family modifications in the replication of DNA damage (2011) (39)
- Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype–phenotype relationships (2007) (39)
- Artefact in the Measurement of the Molecular Weight of Pulse Labelled DNA (1969) (39)
- Molecular biology of DNA repair in the fission yeast Schizosaccharomyces pombe. (1996) (38)
- The effect of methylated oxypurines on the size of newly-synthesized DNA and on the production of chromosome aberrations after UV irradiation in Chinese hamster cells. (1975) (38)
- Postreplication repair of DNA in chick cells: studies using photoreactivation. (1975) (37)
- GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy. (2016) (36)
- Nomenclature of human DNA repair genes. (1994) (36)
- The ataxia-telangiectasia gene: a link between checkpoint controls, neurodegeneration and cancer. (1995) (36)
- Long‐term survival and preservation of natural killer cell activity in a xeroderma pigmentosum patient with spontaneous regression and multiple deposits of malignant melanoma (1991) (34)
- SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities. (2013) (34)
- DNA strand breakage caused by dichlorvos, methyl methanesulphonate and iodoacetamide in Escherichia coli and cultured Chinese hamster cells. (1974) (34)
- Replication of Damaged DNA (2003) (33)
- Proliferating cell nuclear antigen-dependent coordination of the biological functions of human DNA polymerase iota. (2004) (33)
- The replication of DNA in murine lymphoma cells (L5178Y): II. Size of replicating units (1972) (32)
- Differential sensitivities to gamma radiation of human bladder and testicular tumour cell lines. (1988) (32)
- Syndromes associate with trichotodystrophy (1994) (32)
- DNA Polymerases η and ι (2004) (31)
- PYRIMIDINE DIMER SITES ASSOCIATED WITH THE DAUGHTER DNA STRANDS IN UV‐IRRADIATED HUMAN FIBROBLASTS (1978) (30)
- Sunlight‐induced cancer: some new aspects and implications of the xeroderma pigmentosum model (1990) (30)
- Cloning and characterisation of the Schizosaccharomyces pombe rad8 gene, a member of the SNF2 helicase family. (1993) (30)
- Erratum: Trading places: How do DNA polymerases switch during translesion DNA synthesis? (Molecular Cell (May 27, 2005) 18 (499-505) PII: S1097-2765(05)01276-1 and DOI: 10.1016/j.molcel.2005.03.032) (2005) (29)
- DNA repair in the fission yeast, Schizosaccharomyces pombe. (1991) (29)
- Workshop on DNA repair. (1992) (28)
- Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype. (2019) (28)
- Ubiquitin-binding motif of human DNA polymerase η is required for correct localization (2009) (28)
- Nse 2 , a Component of the Smc 5-6 Complex , Is a SUMO Ligase Required for the Response to DNA Damage (2004) (28)
- Two new XPD patients compound heterozygous for the same mutation demonstrate diverse clinical features. (2005) (28)
- TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin (2015) (27)
- Poly(ADP-ribosylation) reduces the steady-state level of breaks in DNA following treatment of human cells with alkylating agents. (1984) (26)
- A human subject with a new defect in repair of ultraviolet damage. (1978) (25)
- Correction by the ERCC2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells. (1994) (23)
- Clubbing together on clamps: The key to translesion synthesis. (2006) (22)
- Xeroderma pigmentosum: overview of pharmacology and novel therapeutic strategies for neurological symptoms (2019) (21)
- Duplicated region of sequence similarity to the human XRCC1 DNA repair gene in the Schizosaccharomyces pombe rad4/cut5 gene. (1993) (21)
- DNA joining in mammalian cells. (1993) (21)
- A Gamma-Ray-Resistant Derivative of an Ataxia Telangiectasia Cell Line Obtained Following DNA-Mediated Gene Transfer (1987) (21)
- DIAGNOSIS OF ATAXIA-TELANGIECTASIA BY T-LYMPHOCYTE CLONING ASSAY (1985) (20)
- Minimal ionizing radiation sensitivity in a large cohort of xeroderma pigmentosum fibroblasts. (2008) (20)
- DNA Damage Tolerance and Translesion Synthesis (Chapter 10) (2009) (20)
- No inhibition of endogenous DNA polymerase by synthesis of poly (ADP—ribose) in nuclei from lymphoid cells (1972) (20)
- The induction and characterization of mouse lymphoma L5178Y cell lines resistant to 1-beta-d-arabinofuranosylcytosine. (1980) (19)
- Molecular and Biochemical Characterization of xrs Mutants Defective in Ku 80 (1997) (17)
- Syndromes associated with trichothiodystrophy. (1994) (17)
- Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle (2017) (16)
- The Fidelity of HPV16 E1/E2-mediated DNA Replication* (2003) (16)
- Postreplication Repair of DNA in Mammalian Cells: A Discussion of the Mechanisms and Biological Importance (1976) (16)
- Ubiquitin-PCNA fusion as a mimic for mono-ubiquitinated PCNA in Schizosaccharomyces pombe. (2010) (15)
- WORKSHOP SUMMARY: Replicative Bypass Mechanisms in Mammalian Cells (1978) (15)
- Influence of the live cell DNA marker DRAQ5 on chromatin-associated processes. (2010) (14)
- Workshop on processing of DNA damage. (1996) (14)
- Xeroderma Pigmentosum Variant: 5 Years of Tumour Suppression by Etretinate (1993) (13)
- DNA polymerases eta and iota. (2004) (13)
- Maintaining integrity (2004) (13)
- Protein instability associated with AARS1 and MARS1 mutations causes trichothiodystrophy (2021) (12)
- Localization of Y-family polymerases and the DNA polymerase switch in mammalian cells. (2006) (12)
- A Distinct Genotype of XP Complementation Group A: Surprisingly Mild Phenotype Highly Prevalent in Northern India/Pakistan/Afghanistan. (2016) (11)
- Xeroderma Pigmentosum: A Multidisciplinary Approach (2013) (11)
- UBR5 interacts with the replication fork and protects DNA replication from DNA polymerase η toxicity (2019) (11)
- Checkpoint policing by p53 (1992) (11)
- Mutagenic treatments result in inactivation of expression of a transfected bacterial gene integrated into a human cell line. (1989) (11)
- Confirmation of homozygosity for a single nucleotide substitution mutation in a Cockayne syndrome patient using monoallelic mutation analysis in somatic cell hybrids (1997) (11)
- The Response of Cockayne Syndrome Cells to UV-Irradiation (1981) (10)
- Xeroderma pigmentosum is a definite cause of Huntington's disease‐like syndrome (2017) (10)
- Ageing: Repair and Transcription Keep Us from Premature Ageing (2002) (10)
- Cloning and characterisation of the S . pombe rad 15 gene , a homologue to the S . cerevisiae RAD 3 and human ERCC 2 genes (2004) (10)
- Molecular analysis of the XP-D gene in Italian families with patients affected by trichothiodystrophy and xeroderma pigmentosum group D. (1994) (9)
- Transcriptional changes in trichothiodystrophy cells. (2008) (9)
- Translesion synthesis and error-prone polymerases. (2005) (9)
- Molecular analysis directs the prognosis, management and treatment of patients with xeroderma pigmentosum. (2020) (9)
- Inactivation by nitrogen mustard of plasmids introduced into normal and Fanconi's anaemia cells. (1988) (9)
- Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy: sun sensitivity, DNA repair defects and skin cancer (1996) (8)
- Cancer-Prone Human Disorders with Defects in DNA Repair (1990) (8)
- Workshop on eukaryotic DNA repair genes and gene products. (1995) (8)
- Trichothiodystrophy and the relationship between DNA repair and cancer (1989) (8)
- Trichothiodystrophy with sideroblastic anaemia and developmental delay. (1995) (7)
- Cloning and characterization of the rad 4 gene of Schizosaccharomyces pombe ; a gene showing short regions of sequence similarity to the human XRCC 1 gene (7)
- G2 phase repair of X-ray-induced chromosomal DNA damage in trichothiodystrophy cells. (1995) (7)
- Cloning human DNA repair genes. (1994) (7)
- The ultraviolet sensitivity of Cockayne syndrome cells is not a consequence of reduced cellular NAD content. (1984) (7)
- Xeroderma Pigmentosum in the United Kingdom (2015) (7)
- Repair processes for radiation-induced DNA damage. (1978) (6)
- Cockayne syndrome: report of a Brazilian family with confirmation of impaired RNA synthesis after UV-irradiation (2000) (6)
- Chromatin association of the SMC 5 / 6 complex is dependent on binding of its NSE 3 subunit to DNA (2016) (6)
- Inducible responses to DNA damage (1982) (6)
- Similar rate of O6-ethylguanine elimination from DNA in normal human fibroblast and xeroderma pigmentosum cell strains not transformed by SV40. (1983) (6)
- Identification andCharacterization ofNewElements Involved inCheckpoint andFeedback Controls inFission Yeast (1994) (6)
- DNA damage, repair and the cell cycle. (1994) (6)
- REPAIR OF DNA AND THE MODE OF ACTION OF SENSITIZERS AND PROTECTORS IN BIOLOGICAL SYSTEMS OF DIFFERENT COMPLEXITY. (1970) (6)
- DNA repair, DNA replication and human disorders: a personal journey. (2012) (6)
- Cancer-associated human genetic diseases with defects in DNA repair (2004) (5)
- DNA repair. (1981) (5)
- NAD and the synthesis of (ADP-ribose)n in a human cell strain (46BR) hypersensitive to the lethal effects of 3-aminobenzamide. (1985) (5)
- Chemical Carcinogenesis and Mutagenesis II (1990) (5)
- The melanoma associated antigen 1 ( MAGEA 1 ) protein stimulates the E 3 ubiquitin ligase activity of TRIM 31 within (2019) (5)
- Infantile onset of Cockayne syndrome without photosensitivity in a Tunisian girl. (2009) (5)
- DNA REPLICATION IN NORMAL AND DEFECTIVE HUMAN CELLS AFTER UV IRRADIATION (1978) (5)
- Workshop on Ataxia Telangiectasia (1987) (5)
- Low-fidelity DNA polymerases (2003) (4)
- Instability of extrachromosomal cosmid DNA in SV40-transformed human (ataxia-telangiectasia) cells. (1989) (4)
- Early steps in excision repair (1980) (4)
- DNA repair. (1977) (4)
- Simultaneous disruption of two DNA polymerases , (2019) (4)
- DNA repair deficient photodermatoses. (1990) (4)
- Addendum (2013) (4)
- Human genetic disorders with defects in the repair of deoxyribonucleic acid [proceedings]. (1977) (4)
- CorrigendumCorrigendum to “Co-localization in replication foci and interaction of human Y-family members, DNA polymerase polη and REVl protein”: [DNA Repair 3 (2004) 1503–1514] (2005) (4)
- Postreplication repair of DNA in UV-irradiated mammalian cells. (1975) (3)
- DNA Repair: Disorders (2010) (3)
- Possible methodologies for the detection and study of DNA sequence changes following mutagen exposure: magnetic enrichment in mutant DNA. (1990) (3)
- DNA-binding proteins in xeroderma pigmentosum fibroblasts. (1978) (3)
- DNA Replication in Mammalian Cells Damaged by Mutagens (1981) (3)
- Postreplication Repair in Human Fibroblasts (1977) (3)
- A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad 18 DNA repair protein by arresting the cell cycle following damaging treatments (2013) (3)
- Inhibition of DNA synthesis in ataxia telangiectasia fibroblasts after exposure to DNA-damaging agents (1982) (3)
- Meeting report: EU-US Workshop on Molecular Signatures of DNA Damage-Induced Stress Responses. Cortona, Italy, 26-30 September 2003. (2004) (3)
- Fourth International Workshop on Ataxia-Telangiectasia. (1989) (3)
- The molecular biology of nucleotide excision repair and double-strand break repair in eukaryotes. (1995) (3)
- Assays for the fidelity of DNA polymerases in cell-free extracts of Escherichia coli are complicated by contaminating nucleoside triphosphatases. (1979) (3)
- Metronidazole-Induced Hepatitis in a Teenager With Xeroderma Pigmentosum and Trichothiodystrophy Overlap (2021) (2)
- Ageing, DNA repair of radiation damage and carcinogenesis: fact and fiction. (1985) (2)
- Post–replication repair in normal and defective human fibroblasts (1977) (2)
- Expanding the phenotype of biallelic loss‐of‐function variants in the NSUN2 gene: Description of four individuals with juvenile cataract, chronic nephritis, or brain anomaly as novel complications (2020) (2)
- A novel DNA repair disorder with thrombocytopenia, nephrosis and features overlapping Cockayne syndrome (2009) (2)
- [The dual function of the proliferating cell nuclear antigen (PCNA) in the response of human cells to UV damages]. (1996) (2)
- Changes in Poly(Adenosine Diphosphate Ribose) Polymerase on Stimulation of Pig Lymphocytes with Phytohaemagglutinin (1973) (2)
- The Smc5-Smc6 DNA Repair Complex: Bridging of the SMC5-SMC6heads by the kleisin, Nse4 ... (2006) (2)
- 4 – Molecular Analysis of Genetic and Epigenetic Alterations in Human Cells (1989) (1)
- 30 S DNA: intermediate or artefact? (1974) (1)
- Analysis of Skin Cancers from Xeroderma Pigmentosum Patients Reveals Heterogeneous UV-Induced Mutational Profiles Shaped by DNA Repair (2022) (1)
- The Machinery of Life.David S. Goodsell (1993) (1)
- My Life in Science (2002) (1)
- Nucleotide Excision Repair (NER) (2002) (1)
- XPV DNA Polymerase and Ultraviolet Damage Bypass (2004) (1)
- The UV-response in repair-deficient human syndromes. (1979) (1)
- [Cells of patients with ataxia telangiectasia show a normal capacity of radio-induced reactivation of damaged HSV-1 virus]. (1987) (1)
- Molecular and Biochemical Characterization ofxrsMutants Defective in Ku80 (1997) (1)
- The Cell Cycle, DNA Replication, and Repair (1987) (1)
- XPV Polymerase and the Bypass of Ultraviolet DNA Damage (2013) (1)
- Xeroderma Pigmentosum Cells with Norm Have a Defect in DNA Synthesis after UV (2016) (0)
- Xeroderma Pigmentosum in the UK (2018) (0)
- PCNA and DNA replication (II): The replication of damaged DNA (2006) (0)
- Human DNA polymerase eta - DNA ternary complex with the 5'T of a CPD in the active site (TT2) (2010) (0)
- Xeroderma pigmentosum and HNPCC in the same family (2002) (0)
- The Spectrum of MORC2-Related Disorders: A Potential Link to Cockayne Syndrome (2023) (0)
- Cancer-prone genetic disorders with defects in DNA repair (1985) (0)
- synthesis to UV irradiation . features with cellular sensitivity of RNA Cockayne ' s syndrome : correlation of clinical (0)
- Cloning theRAD51homologue ofSchizosaccharomyces pombe (1993) (0)
- Cloning and characterisation of the Schizosaccharomyces pombe rad 8 gene , a member of the SNF 2 helicase family (2019) (0)
- Faculty Opinions recommendation of Human DNA polymerase iota protects cells against oxidative stress. (2008) (0)
- British Association of Dermatologists Dermatology and Genetic Medicine (2015) (0)
- P IX.1 The rad18 gene from Schizosaccharomyces pombe: A novel essential gene involved in DNA repair (1997) (0)
- Mutations in a general transcription factor, TFIIH result in a novel unlinked form of beta thalassaemia in individuals with trichothiodystrophy. (2001) (0)
- Faculty Opinions recommendation of Evidence that loading of cohesin onto chromosomes involves opening of its SMC hinge. (2006) (0)
- DNA Damage Tolerance and Translesion Synthesis (2009) (0)
- Evolution and function of non-SMC subunits of SMC5/6 complex (2013) (0)
- Book Reviews (1988) (0)
- Defective DNA Repair and Human Disease (1991) (0)
- Biological functions of DNA and methods of testing. (1978) (0)
- P V.18a Analysis of the molecular defect in patients belonging to the group B of Cockayne's syndrome (1997) (0)
- Syndrome Xeroderma Pigmentosum and Cockayne from Patients with Combined Features of Xeroderma Pigmentosum Group D Cells Transcription-Associated Breaks in (2005) (0)
- superfamily involved in DNA repair. pombe defines a new subgroup of the SMC The rad18 gene of Schizosaccharomyces (2014) (0)
- Evolution and functions of SMC complexes: new SMC5/6 insights (2016) (0)
- Making good (1985) (0)
- Sequential assembly of nucleotide excision repair factors at sites of DNA damage in XP-B cells (2006) (0)
- Biochemical manifestations of radiation induced damage in cultured mammalian cells (1973) (0)
- Nse4 is the kleisin component of the Smc5-6 DNA repair complex (2006) (0)
- Proceedings: Ataxia telangiectasia, radiosensitivity at the cellular and molecular level. (1976) (0)
- Title The POLD 3 subunit of DNA polymerase δ can promotetranslesion synthesis independently of DNA polymerase (2019) (0)
- Faculty Opinions recommendation of UmuD and RecA directly modulate the mutagenic potential of the Y family DNA polymerase DinB. (2008) (0)
- Watson and DNA: Making a Scientific Revolution: Victor McElheny, Perseus Publishing, Cambridge, MA, ISBN 0-7382-0341-6 (2003) (0)
- The MAGE and EID proteins affect transcription regulation oftarget genes (2010) (0)
- Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repairytranscription gene (nucleotide excision repairytranscription factor TFIIHyUV irradiation) (1997) (0)
- The NSE3/MAGE interactions with NSE4/EID proteins are evolutionarily conserved (2010) (0)
- The Nse3/MAGE and Nse4/EID proteins are involved intranscription regulation (2010) (0)
- Protein Complex SMC5-6 MAGEG1, That Make Up the Human Identification of the Proteins, Including (2014) (0)
- British Photodermatology Group (2014) (0)
- DNA binding ability of the Nse1-Nse3-Nse4 sub-complex is critical for essential function of the SMC5-6 complex (2013) (0)
- British Photodermatology Group (2010) (0)
- Faculty Opinions recommendation of Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. (2007) (0)
- Faculty Opinions recommendation of Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair. (2006) (0)
- Hypomorphic PCNA mutation underlies a novel human DNA repair disorder (2014) (0)
- Book Review:Molecular Biology and Human Disease. Alexander MacLeod, Karol Sikora (1985) (0)
- An A to G change at a splice donor site of the XPG DNA repair gene is associated with neurologic disease in two adult brothers (2005) (0)
- Repair of x-ray-induced damage in a mammalian cell. Abstr. (1968) (0)
- 分裂酵母での"もうひとつの"DNA除去修復系 (1996) (0)
- DNA binding ability of the Nse1-Nse3-Nse4 sub-complex of the SMC5/6 complex is essential in fission yeast (2014) (0)
- DNA Repair and Mutagenesis, second ed., E.C. Friedberg, G.C. Walker, W. Siede, R.D. Wood, R.A. Schultz, T. Ellenberger. ASM Press, ISBN 1-55581-319-4 (2006) (0)
- Identification of mutations in a trans-acting factor with different effects on alpha and beta globin expression. (2000) (0)
- Evolution of the NSE1-NSE3-NSE4 subcomplex of the human SMC5/6 complex (2015) (0)
- Chromosomal association of the SMC5-6 complex is dependent on interaction of its Nse1-Nse3-Nse4 subcomplex with DNA (2014) (0)
- Xeroderma Pigmentosum Variant Extracts Impaired Translesion Synthesis in (1999) (0)
- Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients (2023) (0)
- P V.18b Molecular alteration in Italian patients affected by xeroderma pigmentosum group C (1997) (0)
- Abnormal Kinetics of DMA Synthesis in Ultraviolet Light-irradiated Cells from Patients with Cockayne ' s Syndrome 1 (2006) (0)
- O V B.1 Mutations in DNA repair genes: Relationships to clinical features (1997) (0)
- The role of (ADP-ribose)n in DNA repair in human cells (1982) (0)
- A study of the uptake, distribution, and genotoxicity of quantum dots of varying properties (2012) (0)
- Assignment of ten DNA repair genes from Schizosaccharomyces pombe to chromosomal NotI restriction fragments (1991) (0)
- Faculty Opinions recommendation of The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. (2007) (0)
- / Mms 2-Ubc 13 Ubiquitin Ligase Complex Controls Error-freeTranslesion Synthesis in Schizosaccharomyces pombe (2010) (0)
- Evolution, functions and pathogenesis of the Nse3 (KITE) subunit of the SMC5/6 complex (2016) (0)
- Syndrome and Xeroderma Pigmentosum Early Defect in Cells from Individuals with Cockayne ' s Failure of RNA Synthesis to Recover after UV Irradiation : An Updated (2006) (0)
- Faculty Opinions recommendation of UvrD facilitates DNA repair by pulling RNA polymerase backwards. (2014) (0)
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