A. Victor Hoffbrand

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A. Victor Hoffbrand

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A. Victor Hoffbrand's Published Works

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Published Works

DEPLETION OF T LYMPHOCYTES IN DONOR MARROW PREVENTS SIGNIFICANT GRAFT-VERSUS-HOST DISEASE IN MATCHED ALLOGENEIC LEUKAEMIC MARROW TRANSPLANT RECIPIENTS (1984) (349)
Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro (1996) (336)
Iron deficiency and overload. (2003) (234)
Role of deferiprone in chelation therapy for transfusional iron overload. (2003) (230)
Effect of Iron Deficiency and Desferrioxamine on DNA Synthesis in Human Cells (1976) (230)
Hepatic iron concentration combined with long‐term monitoring of serum ferritin to predict complications of iron overload in thalassaemia major (2000) (227)
USE OF ANTI-T-CELL MONOCLONAL ANTIBODY OKT3 TO PREVENT ACUTE GRAFT-VERSUS-HOST DISEASE IN ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR ACUTE LEUKAEMIA (1982) (204)
Human B cell development. I. Phenotypic differences of B lymphocytes in the bone marrow and peripheral lymphoid tissue. (1985) (198)
The human thymic microenvironment: an immunohistologic study. (1980) (192)
Long-term trial of deferiprone in 51 transfusion-dependent iron overloaded patients. (1998) (188)
High incidence of cardiomyopathy in beta-thalassaemia patients receiving regular transfusion and iron chelation: reversal by intensified chelation. (1990) (180)
Effective chelation of iron in beta thalassaemia with the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one. (1987) (174)
How I treat transfusional iron overload. (2012) (168)
Mechanisms of Resistance of Human Acute Leukaemia Cells to Cytosine Arabinoside (1974) (168)
Results of long‐term deferiprone (L1) therapy: a report by the International Study Group on Oral Iron Chelators (1995) (166)
PARENTERAL ACYCLOVIR THERAPY FOR HERPESVIRUS INFECTIONS IN MAN (1979) (164)
Interleukin‐4 inhibits apoptotic cell death and loss of the bcl‐2 protein in B‐chronic lymphocytic leukaemia cells in vitro (1993) (160)
Graft rejection following HLA matched T‐lymphocyte depleted bone marrow transplantation (1986) (156)
The history of folic acid (2001) (155)
Terminal Transferase Enzyme Assay and Immunological Membrane Markers in the Diagnosis of Leukaemia: a Multiparameter Analysis of 300 Cases (1980) (154)
TRANSFER OF A FUNCTIONING HUMORAL IMMUNE SYSTEM IN TRANSPLANTATION OF T-LYMPHOCYTE-DEPLETED BONE MARROW (1986) (151)
Efficacy and possible adverse effects of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in thalassemia major. (1992) (151)
Mycophenolate mofetil for the treatment of refractory auto‐immune haemolytic anaemia and auto‐immune thrombocytopenia purpura (2002) (148)
Biochemical and genetic control of apoptosis: relevance to normal hematopoiesis and hematological malignancies. (1999) (148)
Relation of “lymphoid” phenotype and response to chemotherapy incorporating vincristine‐prednisolone in the acute phase of Ph1 positive leukemia (1979) (139)
TERMINAL DEOXYNUCLEOTIDYL-TRANSFERASE LEVELS AND MEMBRANE PHENOTYPES IN DIAGNOSIS OF ACUTE LEUKÆMIA (1977) (138)
Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients (2003) (130)
INVESTIGATION OF MINIMAL RESIDUAL DISEASE IN CHILDHOOD AND ADULT ACUTE LYMPHOBLASTIC LEUKAEMIA BY MOLECULAR ANALYSIS (1999) (125)
Iron chelators induce apoptosis in proliferating cells (1995) (125)
Long‐term trial with the oral iron chelator 1,2‐dimethyl‐3‐hydroxypyrid‐4‐one (L1) I. IRON CHELATION AND METABOLIC STUDIES (1990) (125)
A technique for rapid isolation of bone marrow mononuclear cells using Ficoll‐Metrizoate and the IBM 2991 blood cell processor (1982) (123)
REMISSION INDUCTION WITH ADENOSINE-DEAMINASE INHIBITOR 2'-DEOXYCOFORMYCIN IN THY-LYMPHOBLASTIC LEUKÆMIA (1980) (110)
Expression and function of the FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia. (1995) (107)
Multiparameter studies in lymphoid leukemias. (1979) (105)
Subpopulations of normal and leukemic human thymocytes: an analysis with the use of monoclonal antibodies. (1980) (105)
Expression of the multidrug resistance-associated protein (MRP) in acute leukaemia. (1994) (103)
AGRANULOCYTOSIS AND THROMBOCYTOPENIA IN PATIENT WITH BLACKFAN-DIAMOND ANAEMIA DURING ORAL CHELATOR TRIAL (1989) (102)
ALPHA-INTERFERON THERAPY FOR ESSENTIAL THROMBOCYTHAEMIA (1988) (102)
Insulin Resistance and Iron Overload (1983) (101)
Terminal Deoxynucleotidyl Transferase Expression in Acute Non‐lymphoid Leukaemia: an Analysis by Immunofluorescence (1981) (98)
Long‐term trial with the oral iron chelator 1,2‐dimethy1‐3‐hydroxypyrid‐4‐one (L1) II. CLINICAL OBSERVATIONS (1990) (98)
Serum non‐transferrin‐bound iron in beta‐thalassaemia major patients treated with desferrioxamine and L1 (1992) (98)
SUBCUTANEOUS INFUSION AND INTRAMUSCULAR INJECTION OF DESFERRIOXAMINE IN PATIENTS WITH TRANSFUSIONAL IRON OVERLOAD (1976) (97)
Studies of Folate Uptake by Phytohaemagglutinin‐Stimulated Lymphocytes (1970) (96)
Membrane marker and cell separation studies in Ph1-positive leukemia. (1978) (95)
Immunological monitoring of residual disease in treated thymic acute lymphoblastic leukaemia. (1981) (93)
Pharmacokinetics of the oral iron chelator deferiprone (L1) in patients with iron overload (1995) (93)
Serum ferritin assay and iron status in chronic renal failure and haemodialysis. (1975) (90)
Distribution of terminal deoxynucleotidyl transferase and purine degradative and synthetic enzymes in subpopulations of human thymocytes. (1982) (88)
Treatment of systemic mast cell disease with 2-chlorodeoxyadenosine. (2004) (87)
Development of pluripotent hematopoietic progenitor cells in the human fetus. (1983) (87)
Clinical trial of deferiprone iron chelation therapy in β‐thalassaemia/haemoglobin E patients in Thailand (2003) (86)
Antibody to hepatitis C virus in multiply transfused patients with thalassaemia major. (1990) (86)
Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis (1982) (86)
Genetic and acquired predisposing factors and treatment of osteoporosis in thalassaemia major. (1998) (84)
L1 (1,2‐dimethyl‐3‐hydroxypyrid‐4‐one) for oral iron chelation in patients with beta‐thalassaemia major (1990) (83)
LONG-TERM T-CELL-MEDIATED IMMUNITY TO EPSTEIN-BARR VIRUS IN RENAL-ALLOGRAFT RECIPIENTS RECEIVING CYCLOSPORIN A (1981) (83)
Molecular detection of minimal residual disease in adult and childhood acute lymphoblastic leukaemia reveals differences in treatment response (1997) (83)
Retrogression in testicular seminoma with viable metastases (1965) (82)
MULTIPLE IMMUNE COMPLEXES AND HYPOCOMPLEMENTÆMIA IN DERMATITIS HERPETIFORMIS AND CŒLIAC DISEASE (1976) (82)
Iron state and hepatic disease in patients with thalassaemia major, treated with long term subcutaneous desferrioxamine. (1987) (81)
Iron chelation therapy (1997) (81)
Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis. (2003) (81)
p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism. (2008) (79)
The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro (2006) (79)
"Pre-B" phenotypes in blast crisis of Ph1 positive CML: evidence for a pluripotential stem cell "target". (1979) (78)
Effect of ascorbic acid deficiency on serum ferritin concentration in patients with beta-thalassaemia major and iron overload. (1982) (78)
Lymphocyte Transformation in Megaloblastic Anaemia: Morphology and DNA Synthesis (1970) (77)
Combination therapy with interferon alpha and ribavirin for chronic hepatitis C virus infection in thalassaemic patients (1997) (77)
HOFFBRAND'S ESSENTIAL HAEMATOLOGY (2016) (75)
Orally active α‐ketohydroxy pyridine iron chelators intended for clinical use: in vivo studies in rabbits (1986) (75)
Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation. (2001) (75)
Endocrine Abnormalities in Thalassemia (1990) (74)
ABO-INCOMPATIBLE BONE-MARROW TRANSPLANTATION: REMOVAL OF RED BLOOD CELLS FROM DONOR MARROW AVOIDING RECIPIENT ANTIBODY DEPLETION (1982) (73)
Alpha‐interferon (α‐IFN) protects B‐chronic lymphocytic leukaemia cells from apoptotic cell death in vitro (1994) (72)
Folate deficiency and neurological disease. (1965) (72)
THERAPEUTIC SELECTIVITY OF AND PREDICTION OF RESPONSE TO 2'-DEOXYCOFORMYCIN IN ACUTE LEUKAEMIA (1981) (72)
Induction of tissue factor expression in human monocyte/endothelium cocultures (1995) (71)
Incidence of endocrine complications and clinical disease severity related to genotype analysis and iron overload in patients with β‐thalassaemia (1997) (70)
IMPROVEMENT IN IRON STATUS AND LIVER FUNCTION IN PATIENTS WITH TRANSFUSIONAL IRON OVERLOAD WITH LONG-TERM SUBCUTANEOUS DESFERRIOXAMINE (1979) (70)
Interleukin-6 inhibits apoptosis and tumour necrosis factor induced proliferation of B-chronic lymphocytic leukaemia. (1996) (70)
Binding of G-CSF, GM-CSF, tumor necrosis factor-alpha, and gamma-interferon to cell surface receptors on human myeloid leukemia cells triggers rapid tyrosine and serine phosphorylation of a 75-Kd protein. (1990) (69)
Natural killer cell activity following T‐cell depleted allogeneic bone marrow transplantation (1986) (68)
Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells. (1989) (68)
The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment. (2010) (67)
EFFECT OF DOSE, TIME, AND ASCORBATE ON IRON EXCRETION AFTER SUBCUTANEOUS DESFERRIOXAMINE (1977) (67)
Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. (2002) (65)
Autocrine and paracrine growth loops in chronic lymphocytic leukemia. (1993) (63)
The Role of Deferiprone in Iron Chelation. (2018) (62)
Increased numbers of cells with suppressor T cell phenotype in the peripheral blood of patients with infectious mononucleosis. (1981) (61)
Deferiprone‐associated myelotoxicity (1994) (61)
Reduced rate of DNA replication fork movement in megaloblastic anemia. (1980) (60)
Surface antigenic determinants on human pluripotent and unipotent hematopoietic progenitor cells. (1983) (59)
Alpha interferon in the treatment of chronic hepatitis C infection in thalassaemia major (1993) (59)
Studies on long‐term T‐cell‐mediated immunity to epstein‐barr virus in immunosuppressed renal allograft recipients (1981) (58)
Correction of the DNA synthesis defect in vitamin B12 deficiency by tetrahydrofolate: evidence in favour of the methyl‐folate trap hypothesis as the cause of megaloblastic anaemia in vitamin B12 deficiency (1993) (57)
A and B blood group antigen expression on mixed colony cells and erythroid precursors: relevance for human allogeneic bone marrow transplantation (1984) (56)
Thalassaemia intermedia: a new molecular basis (1984) (56)
Comparative study of iron mobilization from haemosiderin, ferritin and iron(III) precipitates by chelators. (1987) (56)
Macrocytosis in alcohol-related liver disease: its value for screening. (1981) (55)
Cytotoxic and DNA‐inhibitory effects of iron chelators on human leukaemic cell lines (1986) (55)
High incidence of osteoporosis in thalassaemia major. (1998) (55)
Immunofluorescent and Biochemical Studies of Terminal Deoxynucleotidyl Transferase in Treated Acute Leukaemia (1981) (54)
The ontogeny of terminal deoxynucleotidyl transferase positive cells in the human fetus. (1983) (54)
Formation of multinucleated cells in a Hodgkin's‐disease‐derived cell line (1989) (53)
Variable Philadelphia breakpoints and potential lineage restriction of bcr rearrangement in acute lymphoblastic leukemia (1988) (53)
Homozygous protein C deficiency with delayed onset of symptoms at 7 to 10 months. (1989) (53)
ELIMINATION OF T‐LYMPHOCYTES FROM HUMAN BONE MARROW WITH MONOCLONAL T‐ANTIBODIES AND CYTOLYTIC COMPLEMENT (1982) (53)
Effect of various iron chelating agents on DNA synthesis in human cells. (1980) (52)
Okadaic acid‐induced apoptosis of HL60 leukemia cells is preceded by destabilization of bcl‐2 mRNA and downregulation of bcl‐2 protein (1998) (52)
Deoxyribonucleoside Triphosphates in Human Cells: Changes in Disease and Following Exposure to Drugs (1975) (52)
2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. (2009) (51)
Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. (2004) (51)
Zinc concentration in patients with iron overload receiving oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one or desferrioxamine. (1994) (50)
Enzymes of purine metabolism in human peripheral lymphocyte subpopulations. (1982) (50)
The role of purine metabolic enzymes and terminal deoxynucleotidyl transferase in intrathymic T-cell differentiation. (1983) (50)
Megaloblastic anaemia. (2021) (49)
Comparison of Three Methods for Measuring Vitamin B12 in Serum: Radioisotopic, Euglena gracilis and Lactobacillus leichmannii (1972) (49)
A novel delivery system for continuous desferrioxamine infusion in transfusional iron overload (1996) (48)
Terminal deoxynucleotidyl-transferase levels and membrane phenotypes in diagnosis of acute leukaemia. (1977) (48)
Iron chelation studies using desferrioxamine and the potential oral chelator, 1,2-dimethyl-3-hydroxypyrid-4-one, in normal and iron loaded rats. (1987) (48)
Enzyme and membrane markers in leukaemia: recent developments. (1981) (48)
Iron chelation in thalassemia: combined or monotherapy? The Egyptian experience (2008) (48)
Alternative metabolic fates of thymine nucleotides in human cells. (1981) (48)
The effect of external deoxyribonucleosides on deoxyribonucleoside triphosphate concentrations in human lymphocytes. (1975) (47)
X-linked Sideroblastic Anemia Due to Carboxyl-terminal ALAS2 Mutations That Cause Loss of Binding to the β-Subunit of Succinyl-CoA Synthetase (SUCLA2)* (2012) (47)
Non‐benign sickle cell anaemia in western Saudi Arabia (1985) (47)
Studies on the Biochemical Sequelae of Therapy in Thy‐Acute Lymphoblastic Leukaemia with the Adenosine Deaminase Inhibitor 2’Deoxycoformycin (1981) (47)
Circulating monoclonal B lymphocytes in multiple myeloma (1989) (46)
Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage‐induced apoptosis in B‐chronic lymphocytic leukaemia cells (2001) (45)
USE OF BONE-MARROW CULTURE IN PREDICTION OF ACUTE LEUKAEMIC TRANSFORMATION IN PRELEUKAEMIA (1983) (45)
Expression of the human major vault protein LRP in acute myeloid leukemia. (1997) (44)
Indices of granulocyte activity in inflammatory bowel disease (1974) (43)
Iron Metabolism, Iron Deficiency and Disorders of Haem Synthesis (2007) (43)
Failure of purged autologous bone marrow transplantation in high risk acute lymphoblastic leukaemia in first complete remission. (1991) (43)
The membrane phenotype of T-prolymphocytic leukaemia. (2009) (43)
The Effect of Deoxyuridine, Vitamin B12, Folate and Alcohol on the Uptake of Thymidine and on the Deoxynucleoside Triphosphate Concentrations in Normal and Megaloblastic Cells (1978) (43)
Effects of interferon-alpha (IFN) on the expression of interleukin 1-beta (IL-1), interleukin 6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor-alpha (TNF) in acute myeloid leukemia (AML) blasts. (1992) (43)
Qualitative and quantitative studies of antral and fundic G cells in pernicious anaemia. (1973) (42)
Two new mutations in the HIF2A gene associated with erythrocytosis (2012) (42)
Interleukin 2 infusion induces haemopoietic growth factors and modifies marrow regeneration after chemotherapy or autologous marrow transplantation (1991) (42)
A comparison of histocompatibility antigens in dermatitis herpetiformis and adult coeliac disease (1976) (41)
Haem Synthesis in Sideroblastic Anaemia (1979) (41)
Thymidine concentrations in human sera: variations in patients with leukaemia and megaloblastic anaemia. (1980) (41)
Mechanisms of deoxyadenosine toxicity in human lymphoid cells in vitro: relevance to the therapeutic use of inhibitors of adenosine deaminase (1984) (41)
A novel δº mutation in cis with Hb Knossos: a study of different genetic interactions in three Egyptian families (1991) (40)
Adenosine deaminase concentrations in leukaemia and lymphoma: relation to cell phenotypes. (1981) (40)
Infection with Yersinia enterocolitica in patients with iron overload. (1986) (40)
Oral iron chelation. (1996) (40)
Transport of Methotrexate into Normal Haemopoietic Cells and into Leukaemic Cells and its Effects on DNA Synthesis (1973) (39)
Human leukocyte function‐associated antigens on lympho‐hemopoietic precursor cells (1986) (39)
Serum vitamin B12 and transcobalamin levels in early HIV disease (1994) (38)
Terminal deoxynucleotidyl transferase. (1978) (38)
Defective spectrin dimer–dimer association in a family with transfusion dependent homozygous hereditary elliptocytosis (1983) (38)
Deoxycoformycin in the Treatment of Leukemias and Lymphomas a (1985) (36)
Value of serum ferritin estimation in sickle cell anaemia. (1978) (36)
Diagnosing myocardial iron overload. (2001) (36)
Role of ADP-ribosyl transferase in differentiation of human granulocyte-macrophage progenitors to the macrophage lineage. (1983) (36)
Herbimycin A accelerates the induction of apoptosis following etoposide treatment or γ-irradiation of bcr/abl-positive leukaemia cells (1998) (36)
Solubilization and partial characterization of a multienzyme complex of DNA synthesis from human lymphoblastoid cells. (1982) (36)
Serum 1,25 dihydroxyvitamin D and osteocalcin concentrations in thalassaemia major. (1987) (36)
Assessment of hepatic iron overload in thalassemic patients by magnetic resonance spectroscopy (1994) (36)
DCC tumor suppressor gene is inactivated in hematologic malignancies showing monosomy 18 (1993) (35)
Rapid down‐regulation of protein kinase C and membrane association in phorbol ester‐treated leukemia cells (1985) (35)
Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism (1999) (35)
The iron chelators desferrioxamine and 1-alkyl-2-methyl-3-hydroxypyrid-4-ones inhibit vascular prostacyclin synthesis in vitro. (1988) (35)
Thymidylate concentration in megaloblastic anaemia (1974) (34)
E2A/HLF fusion cDNAs and the use of RT-PCR for the detection of minimal residual disease in t(17;19)(q22;p13) acute lymphoblastic leukemia. (1994) (34)
MK 886, an antagonist of leukotriene generation, inhibits DNA synthesis in a subset of acute myeloid leukaemia cells. (1993) (33)
Monocytes induce E‐selectin gene expression in endothelial cells: role of CD11/CD18 and extracellular matrix proteins (1996) (33)
Reversal of desferrioxamine induced auditory neurotoxicity during treatment with Ca-DTPA. (1989) (32)
Virological and serological diagnosis of cytomegalovirus infection in bone marrow allograft recipients (1985) (32)
Uptake of Vitamin B12 by Phytohaemagglutinin‐Transformed Lymphocytes (1973) (32)
Metabolism of thymine nucleotides synthesized via the 'de novo' mechanism in normal, megaloblastic and methotrexate-treated human cells and in a lymphoblastoid cell line. (1981) (32)
Stimulation of Human Haemopoietic Cells by Colony Stimulating Factors: Sensitivity of Leukaemic Cells (1979) (32)
Malignant plasma cells are sensitive to LAK cell lysis: pre‐clinical and clinical studies of interleukin 2 in the treatment of multiple myeloma (1990) (32)
A Technique for the Concentration of Nucleated Bone Marrow Cells for in vitro Manipulation or Cryopreservation Using the IBM 2991 Blood Cell Processor (1983) (31)
Pyoderma gangrenosum outside the context of inflammatory bowel disease treated successfully with infliximab (2005) (31)
Biochemical and immunological differentiation of human thymocytes induced by thymic hormones. (1983) (31)
The JAK2V617F tyrosine kinase mutation identifies clinically latent myeloproliferative disorders in patients presenting with hepatic or portal vein thrombosis (2008) (31)
5'nucleotidase, adenosine deaminase and purine nucleoside phosphorylase activities in acute leukaemia. (1982) (31)
Clinical Experience of Clozapine-Induced Neutropenia in the UK (1992) (31)
Phytohemagglutinin treatment of T lymphocytes stimulates rapid increases in activity of both particulate and cytosolic protein kinase C. (1986) (30)
Gel filtration of a complex of DNA polymerase and DNA precursor-synthesizing enzymes from a human lymphoblastoid cell line. (1983) (30)
Human large granular lymphocytes induce immunoglobulin synthesis after bone marrow transplantation (1987) (30)
Haematology at a Glance (2000) (30)
Human T lymphocytes stimulated by phytohaemagglutinin undergo a single round of cell division without a requirement for interleukin-2 or accessory cells. (1987) (30)
Reactivity of Monoclonal Antibodies with Human Myeloid Precursor Cells (1981) (30)
Hypothalamic-Pituitary-Gonadal Axis in Thalassemic Patients With Secondary Amenorrhea (1988) (30)
Role of double-stranded RNA-activated protein kinase in human hematological malignancies. (1997) (29)
Therapeutic and prognostic implications of glucocorticoid receptors and terminal deoxynucleotidyl transferase in acute leukemia. (1982) (29)
5 Results of long-term subcutaneous desferrioxamine therapy (1989) (28)
Cytotoxic effects of the lipophilic iron chelator omadine (1986) (28)
Deletion analysis of chromosome 13q14.3 and characterisation of an alternative splice form of LEU1 in B cell chronic lymphocytic leukemia (2002) (28)
Platelet‐derived growth factor stimulates growth of highly enriched multipotent haemopoietic progenitors (1986) (27)
DETECTION OF LEUKÆMIC LYMPHOBLASTS IN CSF BY IMMUNOFLUORESCENCE FOR TERMINAL TRANSFERASE (1980) (27)
Hypoparathyroidism and hypocalcaemia during treatment for acute leukaemia. (1982) (27)
Recovery of immurioglobulin isotypes following T‐cell depleted allogeneic bone marrow transplantation (1986) (26)
Interlaboratory comparison of serum vitamin B12 assay. (1980) (26)
Analysis of signal transduction in B chronic lymphocytic leukemia cells. (1988) (26)
Serum Lysozyme and Vitamin B12 Binding Capacity in Myeloproliferative Disorders (1971) (26)
Folic acid fortification and cancer risk (2007) (26)
Synergistic action of calcium ionophore A23187 and phorbol ester TPA on B-chronic lymphocytic leukemia cells. (1987) (26)
Stimulation of Human Haemopoietic Cells by Colony Stimulating Factors: Adherent Cell Dependent Colony Stimulating Activity in Human Serum (1977) (26)
Analysis of ETV6/AML1 abnormalities in acute lymphoblastic leukaemia: incidence, alternative spliced forms and minimal residual disease value (2000) (25)
Molecular analysis of the leukaemic B cell in adult and childhood acute lymphoblastic leukaemia (1996) (25)
Thymidine Kinase in Megaloblastic Anaemia (1976) (25)
Possible mechanism of selective killing of myeloid leukemic blast cells by lymphokine-activated killer cells. (1991) (25)
Red cell indices and serum ferritin levels in children. (1977) (25)
Alpha interferon therapy for haematological malignancies: correlation between in vivo induction of the 2′,5′ oligoadenylate system and clinical response (1990) (24)
Serum ferritin in megaloblastic anaemia. (2009) (24)
Binding of serum ferritin to concanavalin A in patients with iron overload and with chronic liver disease. (1982) (24)
Interleukin-2 induces rapid phosphorylation of an 85 kilodalton protein in permeabilized lymphocytes. (1985) (24)
FLAG-idarubicin and allogeneic stem cell transplantation for Ph-positive ALL beyond first remission (1998) (23)
Synergistic action of calcium ionophore A23187 and protein kinase C activator bryostatin 1 on human B cell activation and proliferation (1990) (23)
The effects of deoxycoformycin and deoxyadenosine on deoxyribonucleotide concentrations in leukaemic cells (1982) (23)
The effect of folate analogues and vitamin B12 on provision of thymine nucleotides for DNA synthesis in megaloblastic anemia. (1982) (23)
Iron chelation therapy. (2000) (23)
Biochemical markers in leukaemia and lymphoma. (1979) (23)
New Approaches to the Management of Hepatitis and Endocrine Disorders in Cooley's Anemia (1998) (23)
Recurrence of acute leukemia in donor cells after bone marrow transplantation: documentation by in situ DNA hybridization. (1993) (23)
Deferiprone therapy for transfusional iron overload (2005) (22)
Do leukotrienes play a role in the regulation of proliferation of normal and leukemic hemopoietic cells? (1993) (22)
Gamma-interferon and tumor necrosis factor production after bone marrow transplantation is augmented by exposure to marrow fibroblasts infected with cytomegalovirus. (1990) (22)
Anaemia in adult coeliac disease. (1974) (22)
Hepatic iron clearance from serum in treated hemochromatosis (1978) (22)
Differential toxicity of α‐keto hydroxypyridine iron chelators and desferrioxamine to human haemopoietic precursors in vitro (1994) (22)
Sensitivity of Acute Myeloid Leukaemia Cells to Colony Stimulating Activity: Relation to Response to Chemotherapy (1981) (22)
Agranulocytosis in a patient with thalassaemia major during treatment with the oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one. (1993) (22)
Heterogeneity of VH–JH gene rearrangement patterns: an insight into the biology of B cell precursor ALL (2001) (22)
Platelet function in beta-thalassaemia major. (1979) (22)
The role of platelet-derived growth factor on human pluripotent progenitor (CFU-GEMM) growth in vitro. (1985) (22)
Rapid expression of protooncogenes c-fos and c-myc in B-chronic lymphocytic leukemia cells during differentiation induced by phorbol ester and calcium ionophore. (1989) (22)
The role of serum ferritin in the management of idiopathic haemochromatosis. (1978) (21)
Evidence that guanine-nucleotide binding regulatory proteins couple cell-surface receptors to the breakdown of inositol-containing lipids during T-lymphocyte mitogenesis. (1987) (21)
Subcutaneous desferrioxamine: the effect of three years' treatment on liver, iron, serum ferritin, and comments on echocardiography. (1982) (21)
Platelet monoamine oxidase activity in megaloblastic anaemia. (1980) (21)
Human thymus/leukaemia-associated antigen (a low-molecular weight form of adenosine deaminase) and the phenotype of leukaemic cells. (1980) (21)
Clone size potential and sensitivity to colony-stimulating activity: differentiation-linked properties of granulocyte-macrophage progenitor cells. (1981) (21)
Inosine monophosphate dehydrogenase activity in acute leukaemia. (1987) (20)
Divergent sensitivities of leukaemic cells to human placental conditioned medium and leucocyte feeder layers. (1980) (20)
Expression of c-fos and c-jun proteins and AP-1 binding activity during cell cycle progression of HL60 cells and phytohemagglutinin-stimulated lymphocytes. (1996) (20)
Postgraduate Haematology: Hoffbrand/Postgraduate Haematology (2010) (20)
Recombinant alpha 2B interferon (IFN) in the treatment of chronic hepatitis C disease in thalassaemia major (TM). (1993) (19)
Defective DNA synthesis in megaloblastic anaemia. Studies employing velocity sedimentation in alkaline sucrose gradients. (1979) (19)
Effect of Chronic Nutritional Iron Deficiency on the Small Intestinal Disaccharidase Activities of Growing Dogs∗ (1969) (19)
Regulation of transcription factors NFκB and AP‐1 following tumour necrosis factor‐α treatment of cells from chronic B cell leukaemia patients (1994) (19)
Comparison of purine degradative enzymes and terminal deoxynucleotidyl transferase in T cell leukaemias and in normal thymic and post‐thymic T cells (1983) (19)
NITROUS OXIDE AND MEGALOBLASTOSIS: BIOCHEMICAL MECHANISM (1978) (18)
Adherent cell dependent colony-stimulating activity in human serum: A granulopoietic regulator? (2009) (18)
Clinical response to deoxycoformycin in chronic lymphoid neoplasms and biochemical changes in circulating malignant cells in vivo. (1988) (18)
The Effect of Androstanes on Granulopoiesis in Vitro and in Vivo (1977) (18)
Killing of T lymphocytes by synthetic ceramide is by a nonapoptotic mechanism and is abrogated following mitogenic activation. (1999) (18)
Importance of platelet-free preparations for evaluating lymphocyte nucleotide levels in inherited or acquired immunodeficiency syndromes. (1983) (18)
Functional compartmentation of DNA precursors in human leukaemoblastoid cell lines (1982) (18)
Higher tyrosine protein kinase activity in resting lymphocytes than in proliferating normal or leukaemic blood cells. (1984) (18)
Appendix II: World Health Organization Classification of Tumours of the Haematopoietic and Lymphoid Tissues (2010) (18)
Quantitative expression of G6PD activity of different phenotypes of G6PD and haemoglobin in a Sudanese population. (1981) (18)
Results of long-term subcutaneous desferrioxamine therapy. (1989) (17)
Flow cytometric assessment of multidrug resistance (MDR) phenotype in acute myeloid leukaemia. (1993) (17)
Evidence that endogenous generation of leukotrienes does not regulate proliferation of malignant hemopoietic cell lines. (1993) (17)
Serum immunoreactive trypsin in beta-thalassaemia major. (1981) (17)
Inactivation of calcium ion-regulating inositol polyphosphate second messengers is impaired in subpopulations of human leukemia cells. (1994) (17)
Expression of proto-oncogene c-jun during differentiation of B-chronic lymphocytic leukemia. (1990) (17)
Quantitation of multidrug resistant MDR1 transcript in acute myeloid leukaemia by non‐isotopic quantitative cDNA‐polymerase chain reaction (1994) (17)
Recombinant interleukin 2 and anti-Tac influence the growth of enriched multipotent hemopoietic progenitors: proposed hypotheses for different responses in early and late progenitors. (1988) (16)
Interleukin-4 (IL-4) inhibits proliferation and spontaneous cytokine release by chronic lymphocytic leukaemia cells. (1994) (16)
Biochemical aspects of acute leukaemia. (1986) (16)
The identification of mixed granulocytic-erythrocytic colonies in vitro. (1984) (16)
Prospects for effective oral iron chelation therapy in man with 1,2-dimethyl-3-hydroxypyrid-4-one and other alpha-ketohydroxypyridines. (1989) (16)
The effect of deferiprone (L1) and desferrioxamine on myelopoiesis using a liquid culture system (1994) (16)
Effect of thymosin and phorbol ester on purine metabolic enzymes and cell surface phenotype in a malignant T-cell line (MOLT-3). (1983) (16)
10 Oral iron-chelating therapy: the L1 experience (1994) (15)
Granulocytic differentiation of HL60 human promyelocytic leukemia cells is preceded by a reduction in levels of inositol lipid-derived second messengers. (1988) (15)
Enzymes of purine metabolism in hairy cell leukemia (1986) (15)
IMMUNOLOGICAL CHARACTERIZATION OF HEMOPOIETIC CELLS IN THE COMMON MARMOSET, RHESUS MONKEY, AND MAN IN SEARCH OF A MODEL FOR HUMAN MARROW TRANSPLANTATION (1981) (15)
Base composition of normal and megaloblastic bone marrow DNA. (1972) (15)
Arthropathy in thalassaemia patients receiving deferiprone (1994) (15)
Deletion of 13q14.3 and not 13q12 is the most common genetic abnormality detected in chronic lymphocytic leukemia cells. (1997) (15)
A myelokathexis‐like variant of myelodysplasia (1989) (15)
13q Deletion in Chronic Lymphocytic Leukemia: Characterization of E4.5, a Novel Chromosome Condensation Regulator-like Guanine Nucleotide Exchange Factor (2003) (15)
Purine degradative enzymes in circulating malignant cells of patients with chronic B cell neoplasia (1987) (15)
Characterization of Hodgkin's disease derived cell line HDLM-2. (1989) (15)
Changes in transferrin saturation after treatment with the oral iron chelator deferiprone in patients with iron overload. (1995) (14)
Serum ferritin levels in beta-thalassaemia trait. (1976) (14)
Hepatic iron clearance from serum in treated hemochromatosis. (1978) (14)
Differential cytotoxicity of deoxyguanosine and 8‐aminoguanosine for human leukemic cell lines and normal bone marrow progenitor cells (1984) (14)
Heterogeneous Blast Cell Crises in Philadelphia Negative Chronic Granulocytic Leukaemia (1981) (14)
Detection of minimal residual disease in ALL. (1993) (14)
Terminal deoxynucleotidyl transferase activity in lymphoma. (1979) (14)
Significance of Large Red Blood Cells (1973) (14)
Interleukin‐2 binding to activated human T lymphocytes triggers generation of cyclic AMP but not of inositol phosphates (1987) (14)
Diastolic Dysfunction and Pulmonary Hypertension in Sickle Cell Anemia: Is There a Role for L-Carnitine Treatment? (2006) (14)
Haem deficiency and chain synthesis (1974) (13)
Possible mechanism of action of interferon alpha in chronic B‐cell malignancies (1991) (13)
Terminal Differentiation of Cord Blood Lymphocytes Induced by Thymosin Fraction 5 and Thymosin Alpha1 (1985) (13)
Terminal Transferase Expression in Relapsed Acute Myeloid Leukaemia (1981) (13)
Defects in signal transduction pathways in chronic B lymphocytic leukemia cells. (1995) (13)
Retinoic acid-induced granulocytic differentiation of HL60 human promyelocytic leukemia cells is preceded by downregulation of autonomous generation of inositol lipid-derived second messengers. (1991) (13)
DNA strand breakage and ADP-ribosyl transferase mediated DNA ligation during stimulation of human bone marrow cells by granulocyte-macrophage colony stimulating activity. (1984) (13)
Induction of macrophage-like differentiation of HL60 human myeloid leukemia cells by phorbol myristate acetate triggers an early decline in inositol lipid breakdown. (1989) (13)
Effect of thymosin on glucocorticoid receptor activity and glucocorticoid sensitivity of human thymocytes. (1984) (13)
Intensive induction and consolidation chemotherapy for adults and children with acute myeloid leukaemia (AML) joint AML trial 1982-1985. (1987) (13)
Red cell aplasia following prolonged D-penicillamine therapy. (1976) (13)
CLINICAL TRIALS WITH ORAL IRON CHELATOR L1 (1989) (13)
The inter- and intra-tribal distribution of red cell G6PD phenotypes in Sudan. (1983) (13)
WHO Classification: Tumours of the Haematopoietic and Lymphoid Tissues (2008) (2015) (12)
Observations on the Biochemical Basis of Megaloblastic Anaemia (1972) (12)
Differentiation restriction in the neutrophil-granulocyte, macrophage, eosinophil-granulocyte pathway: analysis by equilibrium density centrifugation. (1982) (12)
Effects of anti‐TNF monoclonal antibody infusion in patients with hairy cell leukaemia (1992) (12)
T Depletion Using MBG6 and RFT8 Monoclonal Antibody Combination and Complement Lysis Prevents Significant Acute and Chronic GvHD in HLA Matched Allogeneic Marrow Transplants (1985) (12)
Standardization of T‐cell depletion in HLA matched bone marrow transplantation (1986) (12)
Minimal residual disease in acute lymphoblastic leukaemia--PCR analysis of immunoglobulin gene rearrangements. (1993) (12)
Polymerase chain reaction (PCR)‐ and reverse transcription PCR‐based minimal residual disease detection in long‐term follow‐up of childhood acute lymphoblastic leukaemia (2002) (12)
Phytohemagglutinin-induced changes in tyrosine protein kinase and its endogenous substrates in human lymphocytes. (1985) (11)
Potential use of purine nucleosides and enzyme inhibitors for selective depletion of Thy-lymphoblasts from human bone marrow. (1986) (11)
Analysis of Rejection in HLA Matched T-Depleted Bone Marrow Transplants (1985) (11)
Differential expression of MHC class II antigens in chronic B-cell disorders. (1988) (11)
Folic acid fortification in the prevention of neural tube defects. (2004) (10)
Unusual megaloblastic anaemia wiht multinucleate erythroblasts: two cases with septicaemia and acute renal failure. (1975) (10)
Progressive Arterial Thrombosis in a Patient with Non-Hodgkin's Lymphoma, a Lupus Anticoagulant, Factor V Leiden Mutation and Paraprotein, Following Chemotherapy (2001) (10)
Purine degradative enzymes and immunological phenotypes in chronic B‐lymphocytic leukaemia: indications that leukaemic immunocytoma is a separate entity (1986) (10)
A novel delta 0 mutation in cis with Hb Knossos: a study of different genetic interactions in three Egyptian families. (1991) (10)
Redox reagents and staurosporine inhibit stimulation of the transcription regulator NF-kappa B following tumour necrosis factor treatment of chronic B-leukaemia cells. (1994) (10)
Postgraduate Haematology: Hoffbrand/Postgraduate (2015) (10)
Mitogen treatment of permeabilized human T lymphocytes stimulates rapid tyrosine and serine phosphorylation of a 42 kDa protein (1986) (10)
Biochemical mechanisms of deoxycoformycin toxicity in chronic leukemias. (1987) (10)
Cell Surface and Enzyme Markers of Cord Blood Lymphocytes (1980) (10)
Pancreatic lipase in serum of patients with beta-thalassemia major. (1983) (10)
Proceedings: Effect of iron deficiency on DNA synthesis. (1974) (10)
CD5-positive B cells after T cell depleted bone marrow transplantation. (1987) (10)
Prospects for oral iron chelation therapy. (1994) (10)
CARDIAC TRANSPLANTATION FOR DOXORUBICIN‐INDUCED CARDIOMYOPATHY IN ACUTE MYELOID LEUKAEMIA (1990) (9)
Occurrence of particular isoenzymes in fresh and cultured leukemia‐lymphoma cells. III. Esterase isoenzyme in monocytes (1987) (9)
Production of anti‐cytomegalovirus antibody following T‐cell depleted bone marrow transplant (1986) (9)
Color Atlas of Clinical Hematology (1994) (9)
Gene probe analysis demonstrates independent clonal evolution of co‐existent chronic myeloid and chronic lymphocytic leukaemia (1988) (9)
Iron chelation therapy: the need for orally active drugs. (1998) (9)
Absence of Kirsten-ras oncogene activation in B-cell chronic lymphocytic leukemia. (1988) (9)
Bone marrow endogenous colony stimulating factor(s): relation to granulopoiesis in vivo. (1981) (9)
Effect of platelet-derived growth factor on enriched populations of haemopoietic progenitors from patients with chronic myeloid leukaemia. (1987) (9)
Impaired degradation of Ca(2+)-regulating second messengers in myeloid leukemia cells. Implications for the regulation of leukemia cell proliferation. (1992) (8)
THE METHYLFOLATE TRAP (1975) (8)
Oral iron-chelating therapy: the L1 experience. (1994) (8)
Nucleoside incorporation into DNA and RNA in acute leukaemia: differences between the various leukaemia sub‐types (1982) (8)
Inhibitors of arachidonic acid lipoxygenase impair the stimulation of inositol phospholipid hydrolysis by the T lymphocyte mitogen phytohaemagglutinin (1989) (8)
Differential expression of TRAP Isoenzyme in B-CLL Cells Treated with Different Inducers. (1990) (8)
The relative sensitivity of peripheral blood T-lymphocyte colony forming cells and bone marrow CFU-GM to deoxyadenosine and 2'deoxycoformycin. (1985) (8)
Hepatitis B virus infection in thalassaemia major treated in London and Athens. (1984) (7)
Use of the X-chromosome linked hypoxanthine phosphoribosyl transferase gene as a marker of cell monoclonality in hemopoietic malignancies. (1988) (7)
How I treat How I treat transfusional iron overload (2012) (7)
Expression of tartrate‐resistant acid phosphatase in B‐CLL treated with phorbol ester or phorbol ester plus calcium ionophore (1988) (7)
Inhibition by aphidicolin and dideoxythymidine triphosphate of a multienzyme complex of DNA synthesis from human cells (1983) (7)
Oxidative effects of iron on erythrocytes. (1985) (7)
Paraneoplastic pemphigus associated with systemic mastocytosis (2009) (7)
Deoxyribonucleoside triphosphate pools in human bone marrow and leukaemic cells. (1980) (7)
Cone-rod dystrophy in thiamine-responsive megaloblastic anemia. (2003) (7)
Prevention of urate nephropathy in the tumour lysis syndrome. (1989) (7)
Interferon-alpha inducible 2'-5' oligoadenylate synthetase transcripts in lymphoid and myeloid leukemias. (1993) (7)
Serum Pancreatic Lipase in β-Thalassaemia Major (1983) (7)
Sexual performance and fertility potential in patients with beta thalassemia major. (1989) (7)
Haem synthesis in sideroblastic anaemia. (1976) (7)
DNA synthesis in isolated lymphocyte nuclei. Effects of megaloblastic anaemia due to folate or vitamin B-12 deficiency or antimetabolite drugs. (1977) (6)
Rapid recovery of helper activity following T cell depleted allogeneic marrow transplant. (1987) (6)
DNA Synthesis in Thymic‐Acute Lymphoblastic Leukaemia (1981) (6)
Enzyme activities of leukemic cells and biochemical changes induced by deoxycoformycin in vitro--lack of correlation with clinical response. (1989) (6)
The influence of extent of resection, type of anastomosis, and ulcer site on the haematological side‐effects of gastrectomy (1970) (6)
Selective toxicity of purine nucleosides to human leukaemic cells. (1989) (6)
Tyrosine protein kinase substrates in Philadelphia-positive human chronic granulocytic leukemia derived cell lines (K562 and BV173): detection by using an immunoblotting technique. (1987) (6)
Esterase Isoenzyme Profiles in Acute and Chronic Leukemias. (1991) (6)
Allogeneic bone marrow transplantation: the monitoring of granulocyte macrophage colonies following the collection of bone marrow mononuclear cells and after the subsequent in‐vitro cytolysis of OKT3 positive lymphocytes (1983) (6)
Multidrug Resistance in Acute Leukaemia: A Comparative Study of Immunocytochemical and RNA Slot Blot Detection of P-glycoprotein Expression. (1991) (6)
Delayed Induction of Proto-Oncogene Expression in B-CLL Cells by Tumor Necrosis Factor. (1990) (5)
Effective chelation of iron in ? thalassaemia with the oral chelator (2015) (5)
Effects of DDMP and DDEP on the deoxyribonucleoside triphosphate concentrations in human cells. (1977) (5)
Detection of tyrosine protein kinase substrates in fresh leukemia cells and normal blood cells using an immunoblotting technique. (1987) (5)
Deficiency of neutrophil FcR III. (1991) (5)
Differentiation of human acute myeloid leukaemia cells in response to exogenous and endogenous stimuli: different patterns of response suggested by a bioassay system. (1985) (5)
Nutritional and biochemical aspects of vitamin B12 (1979) (5)
Blood product support in patients undergoing chemotherapy and autologous or allogeneic bone marrow transplantation for haematological malignancies. (2008) (5)
Letter: Folic acid deficiency during intensive therapy. (1976) (5)
Megaloblastic anaemia and miscellaneous deficiency anaemias (2010) (5)
Acidic isoferritin stimulates differentiation of normal granulomonocytic progenitors. (1988) (5)
Distinct T lymphocyte subsets affect granulo-monocytic differentiation and proliferation. (1982) (4)
Conversion of partially single-stranded replicating DNA to double-stranded DNA is delayed in megaloblastic anaemia. (1980) (4)
Cardiac complications in homozygous beta-thalassemia. (1989) (4)
Proceedings: Sideroblastic anaemia. (1974) (4)
Lymphoid blast crisis in chronic myeloid leukaemia and Philadelphia positive acute lymphoid leukaemia. (1978) (4)
Achievements in hematology in the twentieth century: an introduction. (1999) (4)
Detection of Minimal Residual Disease in B-Lineage Leukemia by Immunoglobulin Gene Fingerprinting (1992) (4)
Haematology at the Hammersmith Hospital and Royal Postgraduate Medical School 1934–1994 (2003) (4)
Folic acid fortification and cancer risk – Authors' reply (2008) (4)
Clinical haematology : Sandoz atlas (1988) (4)
The effect of the leukemic cell line HL60 and acute myeloblastic leukemic cells before and after induction of differentiation on normal pluripotent hematopoietic progenitors (CFU-GEMM). (1985) (4)
The mechanisms of action of three fluorine substituted cytosine analogs: implications for cancer chemotherapy. (1974) (4)
APAAP IMMUNOPHENOTYPING OF HAEMATOLOGICAL MALIGNANCIES (1986) (3)
Clonal growth of metastatic carcinoma of bronchus in bone marrow culture. (1979) (3)
Plasma albumin activates the phosphatidylinositol-3 kinase/AKT signaling pathway and protects B-CLL cells from spontaneous and chlorambacil-induced apoptosis. (2001) (3)
Recent Advances in the Understanding of Iron Metabolism and Iron-Related Diseases (2009) (3)
Tyrosine protein kinases and their substrates in human leukemia cells. (1985) (3)
The binding of ligands to the 55 kDa component of the interleukin‐2 receptor triggers increased turnover of phosphate bound to an 85 kDa protein (1989) (3)
Research conduct and the case of Nancy Olivieri (2005) (3)
Bone Marrow Transplantation in First CR of Acute Leukaemia using T-Depleted Marrow from HLA Identical Sibling Donors (1986) (3)
52Fe Studies of the Effects of Treatment on Erythropoiesis in Megaloblastic Anaemia (1973) (3)
Chapter 3. Iron Metabolism, Iron Deficiency and Disorders of Haem Synthesis (2007) (3)
An endogenous inhibitor of the protein tyrosine kinase activity of normal and malignant human lymphoid cells. (1989) (3)
A PROFESSOR EMIGRATES (1976) (3)
Increase in 2′,5′‐oligoadenylate synthetase caused by deoxycoformycin in hairy cell leukaemia (1992) (3)
Postgraduate Haematology: Seventh Edition (2015) (3)
Rearrangement of TCR gamma chain gene involving JP1 suggests early thymocyte origin of peripheral T‐cell lymphoma (1989) (2)
Oral iron chelators in the treatment of hematologic diseases. (2005) (2)
Inability of poly-ADP-ribosylation inhibitors to protect peripheral blood lymphocytes from the toxic effects of ADA inhibition. (1989) (2)
Appendix 2: WHO Classification of Tumours of Haemopoietic and Lymphoid Tissues (2005) (2)
Induction of Noxa Via Generation of Reactive Oxygen Species Plays a Key Role in Induction of CLL Cell Apoptosis by Two Novel p53-Independent Cytotoxic Agents. (2009) (2)
METABOLISM OF DEOXYURIDINE-DERIVED NUCLEOTIDES BY MEGALOBLASTIC MARROW-CELLS (1981) (2)
Induction of puberty in patients with beta-thalassemia major. (1987) (2)
Recent advances in haematology (1999) (2)
Investigation of psychotropic drug-induced blood agranulocytosis (1992) (2)
Two major tyrosine protein kinases of resting human T lymphocytes are down‐regulated following mitotic stimulation (1987) (2)
Enzyme patterns in normal lymphocyte subpopulations, lymphoid leukaemias and immunodeficiency syndromes. (1982) (2)
Significance of Cell Differentiation in Acute Myeloid Leukaemia (1975) (2)
Nucleotide metabolism and enzyme inhibitors in thymic acute lymphoblastic leukaemia. (1983) (2)
Folate uptake by lymphocytes. (1969) (2)
Blood and neoplastic diseases: megaloblastic anaemia. (1974) (2)
Antioxidants impair the coupling of cell-surface ligand receptors to the inositol lipid signalling pathway in human T lymphocytes but not in Jurkat T lymphoblastic leukemia cells. Evidence that leukotrienes are not involved in the coupling mechanism. (1993) (2)
Regulation of transcription factors NF kappa B and AP-1 following tumour necrosis factor-alpha treatment of cells from chronic B cell leukaemia patients. (1994) (2)
Activation marker expression on the peripheral blood lymphocytes of normal volunteers, recipients of Interleukin 2 and patients undergoing bone marrow transplantation (1992) (2)
Genetic changes: relevance for diagnosis and detection of minimal residual disease in acute lymphoblastic leukaemia. (1994) (2)
Increase in 2',5'-oligoadenylate synthetase caused by deoxycoformycin in hairy cell leukaemia. (1991) (2)
Iron chelation with oral deferiprone in patients with thalassemia. (1998) (2)
[3H]Thymidine triphosphate incorporation into isolated nuclei. (1976) (2)
Failure of purged autologous bone marrow transplantation in high risk ALL. (1991) (1)
Zap-70 and 19V(H) mutation status in combination with p53 functional analysis identifies the response of poor prognosis B-CLL patients to conventional cytotoxic agents. (2004) (1)
Acid Phosphatase Isoenzyme Profiles in Acute and Chronic Leukemias. (1991) (1)
Management of chronic lymphocytic leukemia: Editorial (2000) (1)
Caspase 3 activation in the absence of cytoplasmic cytochrome C elevation during apoptotic death of B-CLL cells. (1999) (1)
DEFICIENCY OF DAF AND CD16 ON PNH NEUTROPHILS (1990) (1)
Acute leukaemias: biology and treatment. (1986) (1)
Biology of chronic lymphocytic leukemia: Editorial (2000) (1)
The production of terminal deoxynucleotidyl transferase (TdT) positive cells in cultures of human pluripotent hemopoietic progenitor cells. (1983) (1)
PARAPROTEINS IN FOLIC-ACID DEFICIENCY (1966) (1)
Folate and Human Development. Edited by Edward J. Massaro and John M. Rogers (2002) (1)
The role of monoclonal antibodies in the prevention of graft versus host disease (1984) (1)
The Detection of Minimal Residual Disease in Acute Leukemia (2020) (1)
Glucosylceramide synthetase inhibitors sensitise B-CLL cells to cytotoxic agents without reversing P-gp functional activity. (2004) (1)
Purine degradative enzymes in the malignant cells of patients with B-cell leukemia (1985) (1)
Appendix I: Normal Values (2010) (1)
Serum ferritin and binding of serum ferritin to concanavalin A as a tumor marker in patients with primary liver cell cancer and chronic liver disease (1982) (1)
Haematology at a Glance, 4th Edition (2014) (1)
Terminal transferase positive cells in the human bone marrow and thymus. (1982) (1)
PHYTOHEMAGGLUTININ (PHA)-STIMULATED HUMAN LYMPHOCYTES-T UNDERGO ONE ROUND OF DNA-SYNTHESIS AND CELL-DIVISION WITHOUT A REQUIREMENT FOR INTERLEUKIN-2 (IL-2) (1986) (1)
Evidence that inositol phospholipids, but not choline phospholipids, are a potential source of growth-regulating second messenger molecules in HL60 leukaemia cells. (1993) (1)
The use and abuse of folic acid. (1970) (1)
Clinical haematology illustrated : and integrated text and colour atlas (2017) (1)
Editorial (1972) (1)
Pifithrin α, a Selective Inhibitor of p53-Mediated Transcription, Augments Apoptotic Killing of Chronic Lymphocytic Leukemia Cells by Nutlin 3a and Cytotoxic Drugs. (2007) (1)
The p90RSK Inhibitor BI-D1870 Induces Apoptosis in CLL Cells (2011) (1)
leukemia cells and augment their sensitivity to cytotoxic Geldanamycin and Herbimycin A induce apoptotic killing of B-chronic (2003) (1)
INDUCTION OF IMMUNOLOGICAL UNRESPONSIVENESS BY MULTIPLE BLOOD TRANSFUSION IN URAEMIC PATIENTS (1981) (1)
VASCULAR AND PLATELET BLEEDING DISORDERS (2018) (1)
Deferiprone in iron overload. (1995) (1)
Haematological Aspects of Systemic Disease (2015) (1)
40 INABILITY OF POLY-ADP-RIBOSYLATION INHIBITORS TO PROTECT PERIPHERAL BLOOD LYMPHOCYTES FROM THE TOXIC EFFECTS OF ADA INHIBITION (1988) (1)
Hyperinsulinism in iron overload (1984) (1)
Expression of breast cancer resistance protein in malignant cells from patients with leukaemia. (2003) (1)
Relative and absolute deficiency of bone marrow endogenous colony stimulating activity in acute myeloid leukemia: relation to response to chemotherapy. (1982) (1)
A role for C-ABL tyrosine kinase in p53 upregulation and apoptosis in B-CLL cells exposed to chlorambucil (2000) (1)
Indices ofgranulocyte activity ininflammatory bowel disease (1974) (1)
Concluding remarks: Concluding remarks (2002) (1)
CELLULAR BASIS OF HEMATOPOIESIS (2010) (1)
Expression of the mutli-drug resistance associated protein (MRP) in haematological malignancy (1994) (0)
The Role of Multidrug Resistance Proteins and Drug Sensitivity in Relation to Poor Prognosis Identified by ZAP-70 Expression and IgVH Mutation Status in B-CLL. (2004) (0)
An in vitro model of proliferating CLL cells for drug sensitivity analysis (2005) (0)
LACK OF CLONAL BCRA2 GENE DELETION ON CHROMOSOME 13 IN CHRONIC LYMPHOCYTIC LEUKAEMIA: AN UPDATE OF RECENT SCIENTIFIC REPORTS (1998) (0)
ZAP-70 detecting by flow cytometry in cells from chronic lymphocytic leukaemia patients using a highly fluorescent Alexa Flour dye. (2003) (0)
2.32 The p90RSK Inhibitor BI-D1870 Induces Apoptosis in CLL Cells (2011) (0)
Granulocyte-colony-stimulating factor increases neutrophil migration across endothelium without an effect on adhesion - role of PECAM-1 (1994) (0)
Comprar Haematology at a Glance, 4th Edition | Atul Mehta | 9781119969228 | Wiley (2014) (0)
macrophage progenitors to the macrophage lineage Role of ADP-ribosyl transferase in differentiation of human granulocyte- (2011) (0)
Quantitation of the Multi-drug Resistant MDR-1 transcript in acute leukaemia by non-isotopic quantitative cDNA polymerase chain reaction. (1994) (0)
TYROSINE PROTEIN-KINASE SUBSTRATES IN HUMAN-LEUKEMIA CELLS (1985) (0)
Geldanamycin and Herbimycin A induce apoptotic killing of B-chronic lymphocytic leukemia cells and augment their sensitivity to cytotoxic drugs Short Title: Geldanamycin actions on CLL cells (2003) (0)
PERIPHERAL T-CELL DISORDERS (2010) (0)
Clinical haematology illustrated (2013) (0)
transcription-independent mechanism p53-mediated apoptosis of CLL cells: evidence for a (2013) (0)
Effects of interferon-alpha on the expression of interleukin-6, interleukin-1-beta and tumour necrosis factor-alpha in acute myeloid leukaemia blasts. (1992) (0)
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Recent Advances in the Understanding of Iron Metabolism and Related Diseases: Dedicated to Professor Ernest Beutler (2009) (0)
The Role of Deferiprone in Iron Chelation. Reply. (2019) (0)
Comprar Pediatric Hematology | Glennys Howarth | 9781405134002 | Wiley (2009) (0)
Long-term assessment of patients with iron overload receiving deferiprone (1994) (0)
Application of anti-ALL serum and other cell markers for leukaemia diagnosis and analysis of human stem cells. (1978) (0)
Round-Table Discussion (1992) (0)
BENIGN DISORDERS OF PHAGOCYTES (2018) (0)
Appendix 1: Normal Values (2005) (0)
Monoclonal Antibodies in Bone Marrow Transplantation (1982) (0)
Result of the chromosomal anomaly (1999) (0)
Folate Deficiency in Humans (2001) (0)
Combination therapy with interferon alpha and ribavirin for hepatitis C virus (HCV) infection in multiply transfused thalassaemic patients. (1996) (0)
Expression of breast cancer resistance protein (BCRP) in malignant cells from patients with B-chronic lymphocytic leukaemia (B-CLL) and acute lymphoblastic leukemia (ALL). (2000) (0)
Molecular detection of minimal residual disease (MRD) in adult and childhood all reveals differences in treatment response (1995) (0)
Irradiation of HL60 promyelocytic and chronic lymphocytic leukaemic (CLL) cells results in a rapid and transient increase in PP2A-like activity. (1997) (0)
BENIGN DISORDERS OF LYMPHOCYTES (2010) (0)
THE DETECTION OF REARRANGED TCR-GAMMA GENES IN T-CELL ALL BY A RADIOLABELED POLYMERASE CHAIN-REACTION ASSAY (1993) (0)
Acute Leukaemia (1995) (0)
SECONDARY ANEMIA AND BONE MARROW IN NONHEMATOPOIETIC DISORDERS (2010) (0)
Interferon 3' Inhibits Apoptotic Cell Death in B Cell Chronic Lymphocytic Leukemia (2003) (0)
Haematology [Hematology] at a glance (2013) (0)
THE DISCOVERY OF THE CURE FOR PERNICIOUS ANAEMIA, VITAMIN B12 (2011) (0)
Book Review: Bone Marrow: Structure and Function (1985) (0)
Serum1,25dihydroxyvitamin D andosteocalcin concentrations inthalassaemia major (1987) (0)
mRNA encoding the BCL-2 oncoprotein shows a predominantly nuclear distribution in cell lines lacking the t(14;18) translocation, but is exported to the cytoplasm in cells which possess this translocation (1995) (0)
HEPATITIS C IN THALASSAEMIC PATIENTS UNDER 20 YEARS OF AGE (1991) (0)
Deoxycoformycin — an adenosine deaminase inhibitor — for the treatment of refractory T and B cell lymphoma (1987) (0)
Echocardiographic Changes in Patients with Transfunctional Iron Overload (1979) (0)
Microbial aspects of patients with leukaemia (1978) (0)
The putative role of Fas and caspase 8 in the killing of B-CLL cells by cytotoxic drugs and radiation. (1999) (0)
Aplastic anemia: Editorial (2000) (0)
hematopoietic progenitor cells Surface antigenic determinants on human pluripotent and unipotent (2011) (0)
The AKT protein kinase mediates plasma-induced survival of B-CLL cells (2000) (0)
39 SELECTIVE TOXICITY OF PURINE NUCLEOSIDES TO HUMAN T-LEUKAEMIC CELLS (1988) (0)
Increases in cytoplasmic cytochrome c is not a rate-limiting step in the induction of apoptosis of B-CLL cells (2000) (0)
Developments in hematopoietic stem cell transplantation. (2001) (0)
Normal and pathological aspects of iron metebolism: Editorial (2000) (0)
2.33 Modulation of Autophagy by the UPR Results in Apoptosis in CLL Cells (2011) (0)
Comprar Postgraduate Haematology, 6th Edition | A. Victor Hoffbrand | 9781405191807 | Wiley (2010) (0)
Biochemical Basis of Megaloblastosis (1989) (0)
BINDING OF INTERLEUKIN-2 OR ANTI-TAC TO THE HUMAN LYMPHOCYTE-T CELL-SURFACE ACTIVATES A CAMP-DEPENDENT SIGNALING PATHWAY (1988) (0)
HLA matched T-cell depleted allogeneic BMT in the treatment of minimal residual disease (1986) (0)
Biology of human hematopoietic stem cells: Editorial (2001) (0)
Destabilization of spliced and unspliced bcl-2 transcripts precedes okadaic acid-induced apoptosis in HL60 leukemia cells. (1998) (0)
The Sesquiterpene Lactone Parthenolide Rapidly and Selectively Induces Apoptosis of B-Chronic Lymphocytic Leukemia Cells. (2004) (0)
and calcium ionophore lymphocytic leukemia cells during differentiation induced by phorbol ester Rapid expression of protooncogenes c-fos and c-myc in B-chronic (2013) (0)
DIFFERENCES IN DNA-SYNTHESIS BETWEEN LYMPHOBLASTS OF THYMIC AND NON-THYMIC ORIGIN (1981) (0)
MYELOID DIFFERENTIATION IS ASSOCIATED WITH INCREASED TRANSENDOTHELIAL MIGRATION - STUDIES IN HL-60 CELLS (1993) (0)
Biochemical mechanisms of transduction of signals for proliferation and differentiation in normal and malignant haemopoietic cells (1988) (0)
Pernicious Anaemia (1983) (0)
Enzymeandmembrane markers inleukaemia: recent developments (1981) (0)
Generation of reactive oxygen species by parthenolide rapidly and selectively induces apoptosis of B-chronic lymphocytic leukaemia (CLL) cells via a p53 independent pathway (2006) (0)
Dr Chanarin's comments on our study of the deoxyuridine suppression test in vitamin B12 and folate deficiency were not unexpected. In answer to the specific questions: (1993) (0)
Response of neutropenia and anaemia to immunosuppressive therapy: report and bone marrow culture studies. (2008) (0)
the microenvironment lymphocytic leukemia cells: potential for reversal of cytoprotection by cytotoxic agents induced by interleukin-4 treatment of chronic The JAK3-selective inhibitor PF-956980 reverses the resistance to (2011) (0)
GENETIC DISORDERS OF HEMOGLOBIN (2010) (0)
Relationship of purine degradation enzymes and TdT and thymic hormones in the intrathymic T cell differentiation (1984) (0)
Ironstate andhepatic disease inpatients with thalassaemia major, treated withlongterm subcutaneous desferrioxamine (2011) (0)
Differential expression of the alternatively spliced STAT-1 alpha and beta mRNA and its products in B-CLL and tonsillar B-cells. (1999) (0)
Bone Marrow: Structure and Function. (1985) (0)
Multiple tyrosine protein kinases structurally related to p56 lck are down-regulated following mitogenic stimulation of human T lymphocytes. (1990) (0)
Biochemical abnormalities in acute leukaemia (1986) (0)
THE PORPHYRIAS AND IRON OVERLOAD (2018) (0)
THE ENZYMATIC DEGRADATION OF A CALCIUM-REGULATING 2ND MESSENGER IS DEFECTIVE IN CELLS FROM A SUBSET OF LEUKEMIA PATIENTS (1993) (0)
Letter: A professor emigrates. (1971) (0)
Targeted therapy with an amphipathic peptide results in selective apoptotic cell death in CD19 positive chronic lymphocytic leukemia cells (2003) (0)
Concluding Remarks (1992) (0)
Inhibitor of apoptosis XIAP expression in cells from B-CLL patients treated with DNA damaging agents. (2001) (0)
NORMAL BLOOD-CELLS CONTAIN HIGHER TYROSINE PROTEIN-KINASE ACTIVITY THAN LEUKEMIC-CELL LINES (1985) (0)
human fetus The ontogeny of terminal deoxynucleotidyl transferase positive cells in the (2011) (0)
Letter: Haem deficiency and chain synthesis. (1974) (0)
Reviews in Clinical and Experimental Hematology: Editorial (2002) (0)
Gene expression of multidrug resistant protein (MRP) homologues in B-CLL and AML cells (2000) (0)
dimethyl-3-hydroxypyrid-4-one ( L 1 ) in thalassemia major [ see Efficacy and possible adverse effects of the oral iron chelator 1 (2003) (0)
nucleotides for DNA synthesis in megaloblastic anemia The effect of folate analogues and vitamin B12 on provision of thymine (2011) (0)
Molecular basis of leukaemia and lymphoma (1998) (0)
PIFITHRIN mu ACTIVATES THE UNFOLDED PROTEIN RESPONSE IN CHRONIC LYMPHOCYTIC LEUKEMIA CELLS (2010) (0)
CHRONIC MYELOID (MYELOGENOUS) LEUKEMIAS AND MYELODYSPLASTC/MYELOPROLIFERATIVE NEOPLASMS (2010) (0)
APLASTIC AND DYSERYTHROPOIETIC ANEMIAS (2018) (0)
SerumFerritin AssayandIronStatus inChronic Renal Failure andHaemodialysis (1975) (0)
Case Report: Candida glabrata fungal ball in the oesophagus (1999) (0)
The modulation of multidrug resistance and induction of apoptotic cell death by a PKC inhibitor CGP41251 in B-CLL cells in vitro (1997) (0)
Herbimycin A sensitizes Philadelphia-positive leukemia cells to apoptosis induction but does not downregulate expression of bcl-2 or bcl-X-L. (1997) (0)
MATURATION OF BLOOD CELLS AND THEIR EXAMINATION IN PERIPHERAL BLOOD AND BONE MARROW (2010) (0)
2-Phenylacetylenesulfonamide Upregulates Noxa and Induces p53-Independent Apoptosis of CLL Cells. (2007) (0)
Activation of caspase 8 in the absence of FAS ligation in the killing of B-CLL cells by cytotoxic drugs and radiation (2000) (0)
The protein tyrosine kinase inhibitor herbimycin A augments cytotoxic drug-induced apoptosis in B-CLL cells cultured with interleukln-4 or autologous plasma. (1999) (0)
Alpha Interferon therapy: correlation with 2'5'-oligoadenylate system (1990) (0)
Clinical hematology illustrated (2013) (0)
Platelet function inbeta-thalassaemi a major (2011) (0)
2-phenylacetylenesulphonamide induces p53-independent apoptosis of CLL cells via upregulation of the BH3 protein Noxa (2009) (0)
EFFECTS OF 8-YEAR SUBCUTANEOUS DESFERRIOXAMINE ON HEPATITIS STATUS IN THALASSEMIA MAJOR (1986) (0)
Letter: The methylfolate trap. (1975) (0)
The cytotoxic effects of deoxyguanosine in human lymphoid cells (1984) (0)
Enhanced tissue factor expression due to monocyte - endothelial-cell interaction - modulation by interferon-gamma and the role of ICAM-1 (1994) (0)
Binding ofserumferritin toconcanavalin A in patients withiron overload andwithchronic liver disease (2011) (0)
biochemical changes in circulating malignant cells in vivo Clinical response to deoxycoformycin in chronic lymphoid neoplasms and (2011) (0)
The modulation of multidrug resistance by CGP41251 in B-chronic lymphocytic leukaemia cells in vitro. (1997) (0)
MYELOMA AND RELATED CONDITIONS (2010) (0)
Ansamysins synergise with conventional drugs in apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. (2003) (0)
Long-term chelation with low dose of deferiprone (1998) (0)
THE INHERITED AND ACQUIRED COAGULATION DISORDERS (2010) (0)
Current Hematology and Oncology, Volume 4, Edited by Virgil F. Fairbanks, Year Book Medical Publishers, Inc., Chicago, London. Price: £62.00 (1987) (0)
Granulocyte-macrophage progenitor cell proliferation and differentiation. (1983) (0)
TUMOR NECROSIS FACTOR-MEDIATED INCREASE OF NF-KAPPA-B LEVELS IN CHRONIC-B LEUKEMIA-CELLS INVOLVES REDOX MECHANISMS BUT NOT PROTEIN-KINASE-C (1993) (0)
DNA synthetic and degradative pathways in malignant lymphomas (1985) (0)
Etoposide-induced apoptosis of K562 chronic myeloid leukemia cells is associated with the downregulation of expression of the bcl-2 and bcl-X genes. (1995) (0)
NON-HODGKIN LYMPHOMAS: MATURE B-CELL NEOPLASMS (2010) (0)
Expression of the multidrug resistance protein gene homologues in B-CLL and AML cells. (1999) (0)
TISSUE TYPING AND STEM CELL TRANSPLANTATION (2010) (0)
BINDING OF LIGANDS TO THE 55KD COMPONENT OF THE INTERLEUKIN-2 RECEPTOR TRIGGERS GENERATION OF CYCLIC-AMP (1988) (0)
Cytotoxic effects of deoxyadenosine and deoxycoformycin in human lymphoid cells (1982) (0)

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