A. Victor Hoffbrand
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(Suggest an Edit or Addition)A. Victor Hoffbrand's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- DEPLETION OF T LYMPHOCYTES IN DONOR MARROW PREVENTS SIGNIFICANT GRAFT-VERSUS-HOST DISEASE IN MATCHED ALLOGENEIC LEUKAEMIC MARROW TRANSPLANT RECIPIENTS (1984) (349)
- Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro (1996) (336)
- Iron deficiency and overload. (2003) (234)
- Role of deferiprone in chelation therapy for transfusional iron overload. (2003) (230)
- Effect of Iron Deficiency and Desferrioxamine on DNA Synthesis in Human Cells (1976) (230)
- Hepatic iron concentration combined with long‐term monitoring of serum ferritin to predict complications of iron overload in thalassaemia major (2000) (227)
- USE OF ANTI-T-CELL MONOCLONAL ANTIBODY OKT3 TO PREVENT ACUTE GRAFT-VERSUS-HOST DISEASE IN ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR ACUTE LEUKAEMIA (1982) (204)
- Human B cell development. I. Phenotypic differences of B lymphocytes in the bone marrow and peripheral lymphoid tissue. (1985) (198)
- The human thymic microenvironment: an immunohistologic study. (1980) (192)
- Long-term trial of deferiprone in 51 transfusion-dependent iron overloaded patients. (1998) (188)
- High incidence of cardiomyopathy in beta-thalassaemia patients receiving regular transfusion and iron chelation: reversal by intensified chelation. (1990) (180)
- Effective chelation of iron in beta thalassaemia with the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one. (1987) (174)
- How I treat transfusional iron overload. (2012) (168)
- Mechanisms of Resistance of Human Acute Leukaemia Cells to Cytosine Arabinoside (1974) (168)
- Results of long‐term deferiprone (L1) therapy: a report by the International Study Group on Oral Iron Chelators (1995) (166)
- PARENTERAL ACYCLOVIR THERAPY FOR HERPESVIRUS INFECTIONS IN MAN (1979) (164)
- Interleukin‐4 inhibits apoptotic cell death and loss of the bcl‐2 protein in B‐chronic lymphocytic leukaemia cells in vitro (1993) (160)
- Graft rejection following HLA matched T‐lymphocyte depleted bone marrow transplantation (1986) (156)
- The history of folic acid (2001) (155)
- Terminal Transferase Enzyme Assay and Immunological Membrane Markers in the Diagnosis of Leukaemia: a Multiparameter Analysis of 300 Cases (1980) (154)
- TRANSFER OF A FUNCTIONING HUMORAL IMMUNE SYSTEM IN TRANSPLANTATION OF T-LYMPHOCYTE-DEPLETED BONE MARROW (1986) (151)
- Efficacy and possible adverse effects of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in thalassemia major. (1992) (151)
- Mycophenolate mofetil for the treatment of refractory auto‐immune haemolytic anaemia and auto‐immune thrombocytopenia purpura (2002) (148)
- Biochemical and genetic control of apoptosis: relevance to normal hematopoiesis and hematological malignancies. (1999) (148)
- Relation of “lymphoid” phenotype and response to chemotherapy incorporating vincristine‐prednisolone in the acute phase of Ph1 positive leukemia (1979) (139)
- TERMINAL DEOXYNUCLEOTIDYL-TRANSFERASE LEVELS AND MEMBRANE PHENOTYPES IN DIAGNOSIS OF ACUTE LEUKÆMIA (1977) (138)
- Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients (2003) (130)
- INVESTIGATION OF MINIMAL RESIDUAL DISEASE IN CHILDHOOD AND ADULT ACUTE LYMPHOBLASTIC LEUKAEMIA BY MOLECULAR ANALYSIS (1999) (125)
- Iron chelators induce apoptosis in proliferating cells (1995) (125)
- Long‐term trial with the oral iron chelator 1,2‐dimethyl‐3‐hydroxypyrid‐4‐one (L1) I. IRON CHELATION AND METABOLIC STUDIES (1990) (125)
- A technique for rapid isolation of bone marrow mononuclear cells using Ficoll‐Metrizoate and the IBM 2991 blood cell processor (1982) (123)
- REMISSION INDUCTION WITH ADENOSINE-DEAMINASE INHIBITOR 2'-DEOXYCOFORMYCIN IN THY-LYMPHOBLASTIC LEUKÆMIA (1980) (110)
- Expression and function of the FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia. (1995) (107)
- Multiparameter studies in lymphoid leukemias. (1979) (105)
- Subpopulations of normal and leukemic human thymocytes: an analysis with the use of monoclonal antibodies. (1980) (105)
- Expression of the multidrug resistance-associated protein (MRP) in acute leukaemia. (1994) (103)
- AGRANULOCYTOSIS AND THROMBOCYTOPENIA IN PATIENT WITH BLACKFAN-DIAMOND ANAEMIA DURING ORAL CHELATOR TRIAL (1989) (102)
- ALPHA-INTERFERON THERAPY FOR ESSENTIAL THROMBOCYTHAEMIA (1988) (102)
- Insulin Resistance and Iron Overload (1983) (101)
- Terminal Deoxynucleotidyl Transferase Expression in Acute Non‐lymphoid Leukaemia: an Analysis by Immunofluorescence (1981) (98)
- Long‐term trial with the oral iron chelator 1,2‐dimethy1‐3‐hydroxypyrid‐4‐one (L1) II. CLINICAL OBSERVATIONS (1990) (98)
- Serum non‐transferrin‐bound iron in beta‐thalassaemia major patients treated with desferrioxamine and L1 (1992) (98)
- SUBCUTANEOUS INFUSION AND INTRAMUSCULAR INJECTION OF DESFERRIOXAMINE IN PATIENTS WITH TRANSFUSIONAL IRON OVERLOAD (1976) (97)
- Studies of Folate Uptake by Phytohaemagglutinin‐Stimulated Lymphocytes (1970) (96)
- Membrane marker and cell separation studies in Ph1-positive leukemia. (1978) (95)
- Immunological monitoring of residual disease in treated thymic acute lymphoblastic leukaemia. (1981) (93)
- Pharmacokinetics of the oral iron chelator deferiprone (L1) in patients with iron overload (1995) (93)
- Serum ferritin assay and iron status in chronic renal failure and haemodialysis. (1975) (90)
- Distribution of terminal deoxynucleotidyl transferase and purine degradative and synthetic enzymes in subpopulations of human thymocytes. (1982) (88)
- Treatment of systemic mast cell disease with 2-chlorodeoxyadenosine. (2004) (87)
- Development of pluripotent hematopoietic progenitor cells in the human fetus. (1983) (87)
- Clinical trial of deferiprone iron chelation therapy in β‐thalassaemia/haemoglobin E patients in Thailand (2003) (86)
- Antibody to hepatitis C virus in multiply transfused patients with thalassaemia major. (1990) (86)
- Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis (1982) (86)
- Genetic and acquired predisposing factors and treatment of osteoporosis in thalassaemia major. (1998) (84)
- L1 (1,2‐dimethyl‐3‐hydroxypyrid‐4‐one) for oral iron chelation in patients with beta‐thalassaemia major (1990) (83)
- LONG-TERM T-CELL-MEDIATED IMMUNITY TO EPSTEIN-BARR VIRUS IN RENAL-ALLOGRAFT RECIPIENTS RECEIVING CYCLOSPORIN A (1981) (83)
- Molecular detection of minimal residual disease in adult and childhood acute lymphoblastic leukaemia reveals differences in treatment response (1997) (83)
- Retrogression in testicular seminoma with viable metastases (1965) (82)
- MULTIPLE IMMUNE COMPLEXES AND HYPOCOMPLEMENTÆMIA IN DERMATITIS HERPETIFORMIS AND CŒLIAC DISEASE (1976) (82)
- Iron state and hepatic disease in patients with thalassaemia major, treated with long term subcutaneous desferrioxamine. (1987) (81)
- Iron chelation therapy (1997) (81)
- Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis. (2003) (81)
- p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism. (2008) (79)
- The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro (2006) (79)
- "Pre-B" phenotypes in blast crisis of Ph1 positive CML: evidence for a pluripotential stem cell "target". (1979) (78)
- Effect of ascorbic acid deficiency on serum ferritin concentration in patients with beta-thalassaemia major and iron overload. (1982) (78)
- Lymphocyte Transformation in Megaloblastic Anaemia: Morphology and DNA Synthesis (1970) (77)
- Combination therapy with interferon alpha and ribavirin for chronic hepatitis C virus infection in thalassaemic patients (1997) (77)
- HOFFBRAND'S ESSENTIAL HAEMATOLOGY (2016) (75)
- Orally active α‐ketohydroxy pyridine iron chelators intended for clinical use: in vivo studies in rabbits (1986) (75)
- Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation. (2001) (75)
- Endocrine Abnormalities in Thalassemia (1990) (74)
- ABO-INCOMPATIBLE BONE-MARROW TRANSPLANTATION: REMOVAL OF RED BLOOD CELLS FROM DONOR MARROW AVOIDING RECIPIENT ANTIBODY DEPLETION (1982) (73)
- Alpha‐interferon (α‐IFN) protects B‐chronic lymphocytic leukaemia cells from apoptotic cell death in vitro (1994) (72)
- Folate deficiency and neurological disease. (1965) (72)
- THERAPEUTIC SELECTIVITY OF AND PREDICTION OF RESPONSE TO 2'-DEOXYCOFORMYCIN IN ACUTE LEUKAEMIA (1981) (72)
- Induction of tissue factor expression in human monocyte/endothelium cocultures (1995) (71)
- Incidence of endocrine complications and clinical disease severity related to genotype analysis and iron overload in patients with β‐thalassaemia (1997) (70)
- IMPROVEMENT IN IRON STATUS AND LIVER FUNCTION IN PATIENTS WITH TRANSFUSIONAL IRON OVERLOAD WITH LONG-TERM SUBCUTANEOUS DESFERRIOXAMINE (1979) (70)
- Interleukin-6 inhibits apoptosis and tumour necrosis factor induced proliferation of B-chronic lymphocytic leukaemia. (1996) (70)
- Binding of G-CSF, GM-CSF, tumor necrosis factor-alpha, and gamma-interferon to cell surface receptors on human myeloid leukemia cells triggers rapid tyrosine and serine phosphorylation of a 75-Kd protein. (1990) (69)
- Natural killer cell activity following T‐cell depleted allogeneic bone marrow transplantation (1986) (68)
- Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells. (1989) (68)
- The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment. (2010) (67)
- EFFECT OF DOSE, TIME, AND ASCORBATE ON IRON EXCRETION AFTER SUBCUTANEOUS DESFERRIOXAMINE (1977) (67)
- Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. (2002) (65)
- Autocrine and paracrine growth loops in chronic lymphocytic leukemia. (1993) (63)
- The Role of Deferiprone in Iron Chelation. (2018) (62)
- Increased numbers of cells with suppressor T cell phenotype in the peripheral blood of patients with infectious mononucleosis. (1981) (61)
- Deferiprone‐associated myelotoxicity (1994) (61)
- Reduced rate of DNA replication fork movement in megaloblastic anemia. (1980) (60)
- Surface antigenic determinants on human pluripotent and unipotent hematopoietic progenitor cells. (1983) (59)
- Alpha interferon in the treatment of chronic hepatitis C infection in thalassaemia major (1993) (59)
- Studies on long‐term T‐cell‐mediated immunity to epstein‐barr virus in immunosuppressed renal allograft recipients (1981) (58)
- Correction of the DNA synthesis defect in vitamin B12 deficiency by tetrahydrofolate: evidence in favour of the methyl‐folate trap hypothesis as the cause of megaloblastic anaemia in vitamin B12 deficiency (1993) (57)
- A and B blood group antigen expression on mixed colony cells and erythroid precursors: relevance for human allogeneic bone marrow transplantation (1984) (56)
- Thalassaemia intermedia: a new molecular basis (1984) (56)
- Comparative study of iron mobilization from haemosiderin, ferritin and iron(III) precipitates by chelators. (1987) (56)
- Macrocytosis in alcohol-related liver disease: its value for screening. (1981) (55)
- Cytotoxic and DNA‐inhibitory effects of iron chelators on human leukaemic cell lines (1986) (55)
- High incidence of osteoporosis in thalassaemia major. (1998) (55)
- Immunofluorescent and Biochemical Studies of Terminal Deoxynucleotidyl Transferase in Treated Acute Leukaemia (1981) (54)
- The ontogeny of terminal deoxynucleotidyl transferase positive cells in the human fetus. (1983) (54)
- Formation of multinucleated cells in a Hodgkin's‐disease‐derived cell line (1989) (53)
- Variable Philadelphia breakpoints and potential lineage restriction of bcr rearrangement in acute lymphoblastic leukemia (1988) (53)
- Homozygous protein C deficiency with delayed onset of symptoms at 7 to 10 months. (1989) (53)
- ELIMINATION OF T‐LYMPHOCYTES FROM HUMAN BONE MARROW WITH MONOCLONAL T‐ANTIBODIES AND CYTOLYTIC COMPLEMENT (1982) (53)
- Effect of various iron chelating agents on DNA synthesis in human cells. (1980) (52)
- Okadaic acid‐induced apoptosis of HL60 leukemia cells is preceded by destabilization of bcl‐2 mRNA and downregulation of bcl‐2 protein (1998) (52)
- Deoxyribonucleoside Triphosphates in Human Cells: Changes in Disease and Following Exposure to Drugs (1975) (52)
- 2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. (2009) (51)
- Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. (2004) (51)
- Zinc concentration in patients with iron overload receiving oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one or desferrioxamine. (1994) (50)
- Enzymes of purine metabolism in human peripheral lymphocyte subpopulations. (1982) (50)
- The role of purine metabolic enzymes and terminal deoxynucleotidyl transferase in intrathymic T-cell differentiation. (1983) (50)
- Megaloblastic anaemia. (2021) (49)
- Comparison of Three Methods for Measuring Vitamin B12 in Serum: Radioisotopic, Euglena gracilis and Lactobacillus leichmannii (1972) (49)
- A novel delivery system for continuous desferrioxamine infusion in transfusional iron overload (1996) (48)
- Terminal deoxynucleotidyl-transferase levels and membrane phenotypes in diagnosis of acute leukaemia. (1977) (48)
- Iron chelation studies using desferrioxamine and the potential oral chelator, 1,2-dimethyl-3-hydroxypyrid-4-one, in normal and iron loaded rats. (1987) (48)
- Enzyme and membrane markers in leukaemia: recent developments. (1981) (48)
- Iron chelation in thalassemia: combined or monotherapy? The Egyptian experience (2008) (48)
- Alternative metabolic fates of thymine nucleotides in human cells. (1981) (48)
- The effect of external deoxyribonucleosides on deoxyribonucleoside triphosphate concentrations in human lymphocytes. (1975) (47)
- X-linked Sideroblastic Anemia Due to Carboxyl-terminal ALAS2 Mutations That Cause Loss of Binding to the β-Subunit of Succinyl-CoA Synthetase (SUCLA2)* (2012) (47)
- Non‐benign sickle cell anaemia in western Saudi Arabia (1985) (47)
- Studies on the Biochemical Sequelae of Therapy in Thy‐Acute Lymphoblastic Leukaemia with the Adenosine Deaminase Inhibitor 2’Deoxycoformycin (1981) (47)
- Circulating monoclonal B lymphocytes in multiple myeloma (1989) (46)
- Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage‐induced apoptosis in B‐chronic lymphocytic leukaemia cells (2001) (45)
- USE OF BONE-MARROW CULTURE IN PREDICTION OF ACUTE LEUKAEMIC TRANSFORMATION IN PRELEUKAEMIA (1983) (45)
- Expression of the human major vault protein LRP in acute myeloid leukemia. (1997) (44)
- Indices of granulocyte activity in inflammatory bowel disease (1974) (43)
- Iron Metabolism, Iron Deficiency and Disorders of Haem Synthesis (2007) (43)
- Failure of purged autologous bone marrow transplantation in high risk acute lymphoblastic leukaemia in first complete remission. (1991) (43)
- The membrane phenotype of T-prolymphocytic leukaemia. (2009) (43)
- The Effect of Deoxyuridine, Vitamin B12, Folate and Alcohol on the Uptake of Thymidine and on the Deoxynucleoside Triphosphate Concentrations in Normal and Megaloblastic Cells (1978) (43)
- Effects of interferon-alpha (IFN) on the expression of interleukin 1-beta (IL-1), interleukin 6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor-alpha (TNF) in acute myeloid leukemia (AML) blasts. (1992) (43)
- Qualitative and quantitative studies of antral and fundic G cells in pernicious anaemia. (1973) (42)
- Two new mutations in the HIF2A gene associated with erythrocytosis (2012) (42)
- Interleukin 2 infusion induces haemopoietic growth factors and modifies marrow regeneration after chemotherapy or autologous marrow transplantation (1991) (42)
- A comparison of histocompatibility antigens in dermatitis herpetiformis and adult coeliac disease (1976) (41)
- Haem Synthesis in Sideroblastic Anaemia (1979) (41)
- Thymidine concentrations in human sera: variations in patients with leukaemia and megaloblastic anaemia. (1980) (41)
- Mechanisms of deoxyadenosine toxicity in human lymphoid cells in vitro: relevance to the therapeutic use of inhibitors of adenosine deaminase (1984) (41)
- A novel δº mutation in cis with Hb Knossos: a study of different genetic interactions in three Egyptian families (1991) (40)
- Adenosine deaminase concentrations in leukaemia and lymphoma: relation to cell phenotypes. (1981) (40)
- Infection with Yersinia enterocolitica in patients with iron overload. (1986) (40)
- Oral iron chelation. (1996) (40)
- Transport of Methotrexate into Normal Haemopoietic Cells and into Leukaemic Cells and its Effects on DNA Synthesis (1973) (39)
- Human leukocyte function‐associated antigens on lympho‐hemopoietic precursor cells (1986) (39)
- Serum vitamin B12 and transcobalamin levels in early HIV disease (1994) (38)
- Terminal deoxynucleotidyl transferase. (1978) (38)
- Defective spectrin dimer–dimer association in a family with transfusion dependent homozygous hereditary elliptocytosis (1983) (38)
- Deoxycoformycin in the Treatment of Leukemias and Lymphomas a (1985) (36)
- Value of serum ferritin estimation in sickle cell anaemia. (1978) (36)
- Diagnosing myocardial iron overload. (2001) (36)
- Role of ADP-ribosyl transferase in differentiation of human granulocyte-macrophage progenitors to the macrophage lineage. (1983) (36)
- Herbimycin A accelerates the induction of apoptosis following etoposide treatment or γ-irradiation of bcr/abl-positive leukaemia cells (1998) (36)
- Solubilization and partial characterization of a multienzyme complex of DNA synthesis from human lymphoblastoid cells. (1982) (36)
- Serum 1,25 dihydroxyvitamin D and osteocalcin concentrations in thalassaemia major. (1987) (36)
- Assessment of hepatic iron overload in thalassemic patients by magnetic resonance spectroscopy (1994) (36)
- DCC tumor suppressor gene is inactivated in hematologic malignancies showing monosomy 18 (1993) (35)
- Rapid down‐regulation of protein kinase C and membrane association in phorbol ester‐treated leukemia cells (1985) (35)
- Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism (1999) (35)
- The iron chelators desferrioxamine and 1-alkyl-2-methyl-3-hydroxypyrid-4-ones inhibit vascular prostacyclin synthesis in vitro. (1988) (35)
- Thymidylate concentration in megaloblastic anaemia (1974) (34)
- E2A/HLF fusion cDNAs and the use of RT-PCR for the detection of minimal residual disease in t(17;19)(q22;p13) acute lymphoblastic leukemia. (1994) (34)
- MK 886, an antagonist of leukotriene generation, inhibits DNA synthesis in a subset of acute myeloid leukaemia cells. (1993) (33)
- Monocytes induce E‐selectin gene expression in endothelial cells: role of CD11/CD18 and extracellular matrix proteins (1996) (33)
- Reversal of desferrioxamine induced auditory neurotoxicity during treatment with Ca-DTPA. (1989) (32)
- Virological and serological diagnosis of cytomegalovirus infection in bone marrow allograft recipients (1985) (32)
- Uptake of Vitamin B12 by Phytohaemagglutinin‐Transformed Lymphocytes (1973) (32)
- Metabolism of thymine nucleotides synthesized via the 'de novo' mechanism in normal, megaloblastic and methotrexate-treated human cells and in a lymphoblastoid cell line. (1981) (32)
- Stimulation of Human Haemopoietic Cells by Colony Stimulating Factors: Sensitivity of Leukaemic Cells (1979) (32)
- Malignant plasma cells are sensitive to LAK cell lysis: pre‐clinical and clinical studies of interleukin 2 in the treatment of multiple myeloma (1990) (32)
- A Technique for the Concentration of Nucleated Bone Marrow Cells for in vitro Manipulation or Cryopreservation Using the IBM 2991 Blood Cell Processor (1983) (31)
- Pyoderma gangrenosum outside the context of inflammatory bowel disease treated successfully with infliximab (2005) (31)
- Biochemical and immunological differentiation of human thymocytes induced by thymic hormones. (1983) (31)
- The JAK2V617F tyrosine kinase mutation identifies clinically latent myeloproliferative disorders in patients presenting with hepatic or portal vein thrombosis (2008) (31)
- 5'nucleotidase, adenosine deaminase and purine nucleoside phosphorylase activities in acute leukaemia. (1982) (31)
- Clinical Experience of Clozapine-Induced Neutropenia in the UK (1992) (31)
- Phytohemagglutinin treatment of T lymphocytes stimulates rapid increases in activity of both particulate and cytosolic protein kinase C. (1986) (30)
- Gel filtration of a complex of DNA polymerase and DNA precursor-synthesizing enzymes from a human lymphoblastoid cell line. (1983) (30)
- Human large granular lymphocytes induce immunoglobulin synthesis after bone marrow transplantation (1987) (30)
- Haematology at a Glance (2000) (30)
- Human T lymphocytes stimulated by phytohaemagglutinin undergo a single round of cell division without a requirement for interleukin-2 or accessory cells. (1987) (30)
- Reactivity of Monoclonal Antibodies with Human Myeloid Precursor Cells (1981) (30)
- Hypothalamic-Pituitary-Gonadal Axis in Thalassemic Patients With Secondary Amenorrhea (1988) (30)
- Role of double-stranded RNA-activated protein kinase in human hematological malignancies. (1997) (29)
- Therapeutic and prognostic implications of glucocorticoid receptors and terminal deoxynucleotidyl transferase in acute leukemia. (1982) (29)
- 5 Results of long-term subcutaneous desferrioxamine therapy (1989) (28)
- Cytotoxic effects of the lipophilic iron chelator omadine (1986) (28)
- Deletion analysis of chromosome 13q14.3 and characterisation of an alternative splice form of LEU1 in B cell chronic lymphocytic leukemia (2002) (28)
- Platelet‐derived growth factor stimulates growth of highly enriched multipotent haemopoietic progenitors (1986) (27)
- DETECTION OF LEUKÆMIC LYMPHOBLASTS IN CSF BY IMMUNOFLUORESCENCE FOR TERMINAL TRANSFERASE (1980) (27)
- Hypoparathyroidism and hypocalcaemia during treatment for acute leukaemia. (1982) (27)
- Recovery of immurioglobulin isotypes following T‐cell depleted allogeneic bone marrow transplantation (1986) (26)
- Interlaboratory comparison of serum vitamin B12 assay. (1980) (26)
- Analysis of signal transduction in B chronic lymphocytic leukemia cells. (1988) (26)
- Serum Lysozyme and Vitamin B12 Binding Capacity in Myeloproliferative Disorders (1971) (26)
- Folic acid fortification and cancer risk (2007) (26)
- Synergistic action of calcium ionophore A23187 and phorbol ester TPA on B-chronic lymphocytic leukemia cells. (1987) (26)
- Stimulation of Human Haemopoietic Cells by Colony Stimulating Factors: Adherent Cell Dependent Colony Stimulating Activity in Human Serum (1977) (26)
- Analysis of ETV6/AML1 abnormalities in acute lymphoblastic leukaemia: incidence, alternative spliced forms and minimal residual disease value (2000) (25)
- Molecular analysis of the leukaemic B cell in adult and childhood acute lymphoblastic leukaemia (1996) (25)
- Thymidine Kinase in Megaloblastic Anaemia (1976) (25)
- Possible mechanism of selective killing of myeloid leukemic blast cells by lymphokine-activated killer cells. (1991) (25)
- Red cell indices and serum ferritin levels in children. (1977) (25)
- Alpha interferon therapy for haematological malignancies: correlation between in vivo induction of the 2′,5′ oligoadenylate system and clinical response (1990) (24)
- Serum ferritin in megaloblastic anaemia. (2009) (24)
- Binding of serum ferritin to concanavalin A in patients with iron overload and with chronic liver disease. (1982) (24)
- Interleukin-2 induces rapid phosphorylation of an 85 kilodalton protein in permeabilized lymphocytes. (1985) (24)
- FLAG-idarubicin and allogeneic stem cell transplantation for Ph-positive ALL beyond first remission (1998) (23)
- Synergistic action of calcium ionophore A23187 and protein kinase C activator bryostatin 1 on human B cell activation and proliferation (1990) (23)
- The effects of deoxycoformycin and deoxyadenosine on deoxyribonucleotide concentrations in leukaemic cells (1982) (23)
- The effect of folate analogues and vitamin B12 on provision of thymine nucleotides for DNA synthesis in megaloblastic anemia. (1982) (23)
- Iron chelation therapy. (2000) (23)
- Biochemical markers in leukaemia and lymphoma. (1979) (23)
- New Approaches to the Management of Hepatitis and Endocrine Disorders in Cooley's Anemia (1998) (23)
- Recurrence of acute leukemia in donor cells after bone marrow transplantation: documentation by in situ DNA hybridization. (1993) (23)
- Deferiprone therapy for transfusional iron overload (2005) (22)
- Do leukotrienes play a role in the regulation of proliferation of normal and leukemic hemopoietic cells? (1993) (22)
- Gamma-interferon and tumor necrosis factor production after bone marrow transplantation is augmented by exposure to marrow fibroblasts infected with cytomegalovirus. (1990) (22)
- Anaemia in adult coeliac disease. (1974) (22)
- Hepatic iron clearance from serum in treated hemochromatosis (1978) (22)
- Differential toxicity of α‐keto hydroxypyridine iron chelators and desferrioxamine to human haemopoietic precursors in vitro (1994) (22)
- Sensitivity of Acute Myeloid Leukaemia Cells to Colony Stimulating Activity: Relation to Response to Chemotherapy (1981) (22)
- Agranulocytosis in a patient with thalassaemia major during treatment with the oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one. (1993) (22)
- Heterogeneity of VH–JH gene rearrangement patterns: an insight into the biology of B cell precursor ALL (2001) (22)
- Platelet function in beta-thalassaemia major. (1979) (22)
- The role of platelet-derived growth factor on human pluripotent progenitor (CFU-GEMM) growth in vitro. (1985) (22)
- Rapid expression of protooncogenes c-fos and c-myc in B-chronic lymphocytic leukemia cells during differentiation induced by phorbol ester and calcium ionophore. (1989) (22)
- The role of serum ferritin in the management of idiopathic haemochromatosis. (1978) (21)
- Evidence that guanine-nucleotide binding regulatory proteins couple cell-surface receptors to the breakdown of inositol-containing lipids during T-lymphocyte mitogenesis. (1987) (21)
- Subcutaneous desferrioxamine: the effect of three years' treatment on liver, iron, serum ferritin, and comments on echocardiography. (1982) (21)
- Platelet monoamine oxidase activity in megaloblastic anaemia. (1980) (21)
- Human thymus/leukaemia-associated antigen (a low-molecular weight form of adenosine deaminase) and the phenotype of leukaemic cells. (1980) (21)
- Clone size potential and sensitivity to colony-stimulating activity: differentiation-linked properties of granulocyte-macrophage progenitor cells. (1981) (21)
- Inosine monophosphate dehydrogenase activity in acute leukaemia. (1987) (20)
- Divergent sensitivities of leukaemic cells to human placental conditioned medium and leucocyte feeder layers. (1980) (20)
- Expression of c-fos and c-jun proteins and AP-1 binding activity during cell cycle progression of HL60 cells and phytohemagglutinin-stimulated lymphocytes. (1996) (20)
- Postgraduate Haematology: Hoffbrand/Postgraduate Haematology (2010) (20)
- Recombinant alpha 2B interferon (IFN) in the treatment of chronic hepatitis C disease in thalassaemia major (TM). (1993) (19)
- Defective DNA synthesis in megaloblastic anaemia. Studies employing velocity sedimentation in alkaline sucrose gradients. (1979) (19)
- Effect of Chronic Nutritional Iron Deficiency on the Small Intestinal Disaccharidase Activities of Growing Dogs∗ (1969) (19)
- Regulation of transcription factors NFκB and AP‐1 following tumour necrosis factor‐α treatment of cells from chronic B cell leukaemia patients (1994) (19)
- Comparison of purine degradative enzymes and terminal deoxynucleotidyl transferase in T cell leukaemias and in normal thymic and post‐thymic T cells (1983) (19)
- NITROUS OXIDE AND MEGALOBLASTOSIS: BIOCHEMICAL MECHANISM (1978) (18)
- Adherent cell dependent colony-stimulating activity in human serum: A granulopoietic regulator? (2009) (18)
- Clinical response to deoxycoformycin in chronic lymphoid neoplasms and biochemical changes in circulating malignant cells in vivo. (1988) (18)
- The Effect of Androstanes on Granulopoiesis in Vitro and in Vivo (1977) (18)
- Killing of T lymphocytes by synthetic ceramide is by a nonapoptotic mechanism and is abrogated following mitogenic activation. (1999) (18)
- Importance of platelet-free preparations for evaluating lymphocyte nucleotide levels in inherited or acquired immunodeficiency syndromes. (1983) (18)
- Functional compartmentation of DNA precursors in human leukaemoblastoid cell lines (1982) (18)
- Higher tyrosine protein kinase activity in resting lymphocytes than in proliferating normal or leukaemic blood cells. (1984) (18)
- Appendix II: World Health Organization Classification of Tumours of the Haematopoietic and Lymphoid Tissues (2010) (18)
- Quantitative expression of G6PD activity of different phenotypes of G6PD and haemoglobin in a Sudanese population. (1981) (18)
- Results of long-term subcutaneous desferrioxamine therapy. (1989) (17)
- Flow cytometric assessment of multidrug resistance (MDR) phenotype in acute myeloid leukaemia. (1993) (17)
- Evidence that endogenous generation of leukotrienes does not regulate proliferation of malignant hemopoietic cell lines. (1993) (17)
- Serum immunoreactive trypsin in beta-thalassaemia major. (1981) (17)
- Inactivation of calcium ion-regulating inositol polyphosphate second messengers is impaired in subpopulations of human leukemia cells. (1994) (17)
- Expression of proto-oncogene c-jun during differentiation of B-chronic lymphocytic leukemia. (1990) (17)
- Quantitation of multidrug resistant MDR1 transcript in acute myeloid leukaemia by non‐isotopic quantitative cDNA‐polymerase chain reaction (1994) (17)
- Recombinant interleukin 2 and anti-Tac influence the growth of enriched multipotent hemopoietic progenitors: proposed hypotheses for different responses in early and late progenitors. (1988) (16)
- Interleukin-4 (IL-4) inhibits proliferation and spontaneous cytokine release by chronic lymphocytic leukaemia cells. (1994) (16)
- Biochemical aspects of acute leukaemia. (1986) (16)
- The identification of mixed granulocytic-erythrocytic colonies in vitro. (1984) (16)
- Prospects for effective oral iron chelation therapy in man with 1,2-dimethyl-3-hydroxypyrid-4-one and other alpha-ketohydroxypyridines. (1989) (16)
- The effect of deferiprone (L1) and desferrioxamine on myelopoiesis using a liquid culture system (1994) (16)
- Effect of thymosin and phorbol ester on purine metabolic enzymes and cell surface phenotype in a malignant T-cell line (MOLT-3). (1983) (16)
- 10 Oral iron-chelating therapy: the L1 experience (1994) (15)
- Granulocytic differentiation of HL60 human promyelocytic leukemia cells is preceded by a reduction in levels of inositol lipid-derived second messengers. (1988) (15)
- Enzymes of purine metabolism in hairy cell leukemia (1986) (15)
- IMMUNOLOGICAL CHARACTERIZATION OF HEMOPOIETIC CELLS IN THE COMMON MARMOSET, RHESUS MONKEY, AND MAN IN SEARCH OF A MODEL FOR HUMAN MARROW TRANSPLANTATION (1981) (15)
- Base composition of normal and megaloblastic bone marrow DNA. (1972) (15)
- Arthropathy in thalassaemia patients receiving deferiprone (1994) (15)
- Deletion of 13q14.3 and not 13q12 is the most common genetic abnormality detected in chronic lymphocytic leukemia cells. (1997) (15)
- A myelokathexis‐like variant of myelodysplasia (1989) (15)
- 13q Deletion in Chronic Lymphocytic Leukemia: Characterization of E4.5, a Novel Chromosome Condensation Regulator-like Guanine Nucleotide Exchange Factor (2003) (15)
- Purine degradative enzymes in circulating malignant cells of patients with chronic B cell neoplasia (1987) (15)
- Characterization of Hodgkin's disease derived cell line HDLM-2. (1989) (15)
- Changes in transferrin saturation after treatment with the oral iron chelator deferiprone in patients with iron overload. (1995) (14)
- Serum ferritin levels in beta-thalassaemia trait. (1976) (14)
- Hepatic iron clearance from serum in treated hemochromatosis. (1978) (14)
- Differential cytotoxicity of deoxyguanosine and 8‐aminoguanosine for human leukemic cell lines and normal bone marrow progenitor cells (1984) (14)
- Heterogeneous Blast Cell Crises in Philadelphia Negative Chronic Granulocytic Leukaemia (1981) (14)
- Detection of minimal residual disease in ALL. (1993) (14)
- Terminal deoxynucleotidyl transferase activity in lymphoma. (1979) (14)
- Significance of Large Red Blood Cells (1973) (14)
- Interleukin‐2 binding to activated human T lymphocytes triggers generation of cyclic AMP but not of inositol phosphates (1987) (14)
- Diastolic Dysfunction and Pulmonary Hypertension in Sickle Cell Anemia: Is There a Role for L-Carnitine Treatment? (2006) (14)
- Haem deficiency and chain synthesis (1974) (13)
- Possible mechanism of action of interferon alpha in chronic B‐cell malignancies (1991) (13)
- Terminal Differentiation of Cord Blood Lymphocytes Induced by Thymosin Fraction 5 and Thymosin Alpha1 (1985) (13)
- Terminal Transferase Expression in Relapsed Acute Myeloid Leukaemia (1981) (13)
- Defects in signal transduction pathways in chronic B lymphocytic leukemia cells. (1995) (13)
- Retinoic acid-induced granulocytic differentiation of HL60 human promyelocytic leukemia cells is preceded by downregulation of autonomous generation of inositol lipid-derived second messengers. (1991) (13)
- DNA strand breakage and ADP-ribosyl transferase mediated DNA ligation during stimulation of human bone marrow cells by granulocyte-macrophage colony stimulating activity. (1984) (13)
- Induction of macrophage-like differentiation of HL60 human myeloid leukemia cells by phorbol myristate acetate triggers an early decline in inositol lipid breakdown. (1989) (13)
- Effect of thymosin on glucocorticoid receptor activity and glucocorticoid sensitivity of human thymocytes. (1984) (13)
- Intensive induction and consolidation chemotherapy for adults and children with acute myeloid leukaemia (AML) joint AML trial 1982-1985. (1987) (13)
- Red cell aplasia following prolonged D-penicillamine therapy. (1976) (13)
- CLINICAL TRIALS WITH ORAL IRON CHELATOR L1 (1989) (13)
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- Effects of anti‐TNF monoclonal antibody infusion in patients with hairy cell leukaemia (1992) (12)
- T Depletion Using MBG6 and RFT8 Monoclonal Antibody Combination and Complement Lysis Prevents Significant Acute and Chronic GvHD in HLA Matched Allogeneic Marrow Transplants (1985) (12)
- Standardization of T‐cell depletion in HLA matched bone marrow transplantation (1986) (12)
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- Phytohemagglutinin-induced changes in tyrosine protein kinase and its endogenous substrates in human lymphocytes. (1985) (11)
- Potential use of purine nucleosides and enzyme inhibitors for selective depletion of Thy-lymphoblasts from human bone marrow. (1986) (11)
- Analysis of Rejection in HLA Matched T-Depleted Bone Marrow Transplants (1985) (11)
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- Progressive Arterial Thrombosis in a Patient with Non-Hodgkin's Lymphoma, a Lupus Anticoagulant, Factor V Leiden Mutation and Paraprotein, Following Chemotherapy (2001) (10)
- Purine degradative enzymes and immunological phenotypes in chronic B‐lymphocytic leukaemia: indications that leukaemic immunocytoma is a separate entity (1986) (10)
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- Redox reagents and staurosporine inhibit stimulation of the transcription regulator NF-kappa B following tumour necrosis factor treatment of chronic B-leukaemia cells. (1994) (10)
- Postgraduate Haematology: Hoffbrand/Postgraduate (2015) (10)
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- Proceedings: Effect of iron deficiency on DNA synthesis. (1974) (10)
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- Occurrence of particular isoenzymes in fresh and cultured leukemia‐lymphoma cells. III. Esterase isoenzyme in monocytes (1987) (9)
- Production of anti‐cytomegalovirus antibody following T‐cell depleted bone marrow transplant (1986) (9)
- Color Atlas of Clinical Hematology (1994) (9)
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- THE METHYLFOLATE TRAP (1975) (8)
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- Inhibitors of arachidonic acid lipoxygenase impair the stimulation of inositol phospholipid hydrolysis by the T lymphocyte mitogen phytohaemagglutinin (1989) (8)
- Differential expression of TRAP Isoenzyme in B-CLL Cells Treated with Different Inducers. (1990) (8)
- The relative sensitivity of peripheral blood T-lymphocyte colony forming cells and bone marrow CFU-GM to deoxyadenosine and 2'deoxycoformycin. (1985) (8)
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- DNA Synthesis in Thymic‐Acute Lymphoblastic Leukaemia (1981) (6)
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- HLA matched T-cell depleted allogeneic BMT in the treatment of minimal residual disease (1986) (0)
- Biology of human hematopoietic stem cells: Editorial (2001) (0)
- Destabilization of spliced and unspliced bcl-2 transcripts precedes okadaic acid-induced apoptosis in HL60 leukemia cells. (1998) (0)
- The Sesquiterpene Lactone Parthenolide Rapidly and Selectively Induces Apoptosis of B-Chronic Lymphocytic Leukemia Cells. (2004) (0)
- and calcium ionophore lymphocytic leukemia cells during differentiation induced by phorbol ester Rapid expression of protooncogenes c-fos and c-myc in B-chronic (2013) (0)
- DIFFERENCES IN DNA-SYNTHESIS BETWEEN LYMPHOBLASTS OF THYMIC AND NON-THYMIC ORIGIN (1981) (0)
- MYELOID DIFFERENTIATION IS ASSOCIATED WITH INCREASED TRANSENDOTHELIAL MIGRATION - STUDIES IN HL-60 CELLS (1993) (0)
- Biochemical mechanisms of transduction of signals for proliferation and differentiation in normal and malignant haemopoietic cells (1988) (0)
- Pernicious Anaemia (1983) (0)
- Enzymeandmembrane markers inleukaemia: recent developments (1981) (0)
- Generation of reactive oxygen species by parthenolide rapidly and selectively induces apoptosis of B-chronic lymphocytic leukaemia (CLL) cells via a p53 independent pathway (2006) (0)
- Dr Chanarin's comments on our study of the deoxyuridine suppression test in vitamin B12 and folate deficiency were not unexpected. In answer to the specific questions: (1993) (0)
- Response of neutropenia and anaemia to immunosuppressive therapy: report and bone marrow culture studies. (2008) (0)
- the microenvironment lymphocytic leukemia cells: potential for reversal of cytoprotection by cytotoxic agents induced by interleukin-4 treatment of chronic The JAK3-selective inhibitor PF-956980 reverses the resistance to (2011) (0)
- GENETIC DISORDERS OF HEMOGLOBIN (2010) (0)
- Relationship of purine degradation enzymes and TdT and thymic hormones in the intrathymic T cell differentiation (1984) (0)
- Ironstate andhepatic disease inpatients with thalassaemia major, treated withlongterm subcutaneous desferrioxamine (2011) (0)
- Differential expression of the alternatively spliced STAT-1 alpha and beta mRNA and its products in B-CLL and tonsillar B-cells. (1999) (0)
- Bone Marrow: Structure and Function. (1985) (0)
- Multiple tyrosine protein kinases structurally related to p56 lck are down-regulated following mitogenic stimulation of human T lymphocytes. (1990) (0)
- Biochemical abnormalities in acute leukaemia (1986) (0)
- THE PORPHYRIAS AND IRON OVERLOAD (2018) (0)
- THE ENZYMATIC DEGRADATION OF A CALCIUM-REGULATING 2ND MESSENGER IS DEFECTIVE IN CELLS FROM A SUBSET OF LEUKEMIA PATIENTS (1993) (0)
- Letter: A professor emigrates. (1971) (0)
- Targeted therapy with an amphipathic peptide results in selective apoptotic cell death in CD19 positive chronic lymphocytic leukemia cells (2003) (0)
- Concluding Remarks (1992) (0)
- Inhibitor of apoptosis XIAP expression in cells from B-CLL patients treated with DNA damaging agents. (2001) (0)
- NORMAL BLOOD-CELLS CONTAIN HIGHER TYROSINE PROTEIN-KINASE ACTIVITY THAN LEUKEMIC-CELL LINES (1985) (0)
- human fetus The ontogeny of terminal deoxynucleotidyl transferase positive cells in the (2011) (0)
- Letter: Haem deficiency and chain synthesis. (1974) (0)
- Reviews in Clinical and Experimental Hematology: Editorial (2002) (0)
- Gene expression of multidrug resistant protein (MRP) homologues in B-CLL and AML cells (2000) (0)
- dimethyl-3-hydroxypyrid-4-one ( L 1 ) in thalassemia major [ see Efficacy and possible adverse effects of the oral iron chelator 1 (2003) (0)
- nucleotides for DNA synthesis in megaloblastic anemia The effect of folate analogues and vitamin B12 on provision of thymine (2011) (0)
- Molecular basis of leukaemia and lymphoma (1998) (0)
- PIFITHRIN mu ACTIVATES THE UNFOLDED PROTEIN RESPONSE IN CHRONIC LYMPHOCYTIC LEUKEMIA CELLS (2010) (0)
- CHRONIC MYELOID (MYELOGENOUS) LEUKEMIAS AND MYELODYSPLASTC/MYELOPROLIFERATIVE NEOPLASMS (2010) (0)
- APLASTIC AND DYSERYTHROPOIETIC ANEMIAS (2018) (0)
- SerumFerritin AssayandIronStatus inChronic Renal Failure andHaemodialysis (1975) (0)
- Case Report: Candida glabrata fungal ball in the oesophagus (1999) (0)
- The modulation of multidrug resistance and induction of apoptotic cell death by a PKC inhibitor CGP41251 in B-CLL cells in vitro (1997) (0)
- Herbimycin A sensitizes Philadelphia-positive leukemia cells to apoptosis induction but does not downregulate expression of bcl-2 or bcl-X-L. (1997) (0)
- MATURATION OF BLOOD CELLS AND THEIR EXAMINATION IN PERIPHERAL BLOOD AND BONE MARROW (2010) (0)
- 2-Phenylacetylenesulfonamide Upregulates Noxa and Induces p53-Independent Apoptosis of CLL Cells. (2007) (0)
- Activation of caspase 8 in the absence of FAS ligation in the killing of B-CLL cells by cytotoxic drugs and radiation (2000) (0)
- The protein tyrosine kinase inhibitor herbimycin A augments cytotoxic drug-induced apoptosis in B-CLL cells cultured with interleukln-4 or autologous plasma. (1999) (0)
- Alpha Interferon therapy: correlation with 2'5'-oligoadenylate system (1990) (0)
- Clinical hematology illustrated (2013) (0)
- Platelet function inbeta-thalassaemi a major (2011) (0)
- 2-phenylacetylenesulphonamide induces p53-independent apoptosis of CLL cells via upregulation of the BH3 protein Noxa (2009) (0)
- EFFECTS OF 8-YEAR SUBCUTANEOUS DESFERRIOXAMINE ON HEPATITIS STATUS IN THALASSEMIA MAJOR (1986) (0)
- Letter: The methylfolate trap. (1975) (0)
- The cytotoxic effects of deoxyguanosine in human lymphoid cells (1984) (0)
- Enhanced tissue factor expression due to monocyte - endothelial-cell interaction - modulation by interferon-gamma and the role of ICAM-1 (1994) (0)
- Binding ofserumferritin toconcanavalin A in patients withiron overload andwithchronic liver disease (2011) (0)
- biochemical changes in circulating malignant cells in vivo Clinical response to deoxycoformycin in chronic lymphoid neoplasms and (2011) (0)
- The modulation of multidrug resistance by CGP41251 in B-chronic lymphocytic leukaemia cells in vitro. (1997) (0)
- MYELOMA AND RELATED CONDITIONS (2010) (0)
- Ansamysins synergise with conventional drugs in apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. (2003) (0)
- Long-term chelation with low dose of deferiprone (1998) (0)
- THE INHERITED AND ACQUIRED COAGULATION DISORDERS (2010) (0)
- Current Hematology and Oncology, Volume 4, Edited by Virgil F. Fairbanks, Year Book Medical Publishers, Inc., Chicago, London. Price: £62.00 (1987) (0)
- Granulocyte-macrophage progenitor cell proliferation and differentiation. (1983) (0)
- TUMOR NECROSIS FACTOR-MEDIATED INCREASE OF NF-KAPPA-B LEVELS IN CHRONIC-B LEUKEMIA-CELLS INVOLVES REDOX MECHANISMS BUT NOT PROTEIN-KINASE-C (1993) (0)
- DNA synthetic and degradative pathways in malignant lymphomas (1985) (0)
- Etoposide-induced apoptosis of K562 chronic myeloid leukemia cells is associated with the downregulation of expression of the bcl-2 and bcl-X genes. (1995) (0)
- NON-HODGKIN LYMPHOMAS: MATURE B-CELL NEOPLASMS (2010) (0)
- Expression of the multidrug resistance protein gene homologues in B-CLL and AML cells. (1999) (0)
- TISSUE TYPING AND STEM CELL TRANSPLANTATION (2010) (0)
- BINDING OF LIGANDS TO THE 55KD COMPONENT OF THE INTERLEUKIN-2 RECEPTOR TRIGGERS GENERATION OF CYCLIC-AMP (1988) (0)
- Cytotoxic effects of deoxyadenosine and deoxycoformycin in human lymphoid cells (1982) (0)
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