Anthony Y. H. Lu
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Anthony Y. H. Lumedical Degrees
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Anthony Y. H. Luphilosophy Degrees
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Medical Philosophy
Anthony Y. H. Lu's Degrees
- PhD Pharmacology University of California, San Francisco
- Doctorate Medicine University of California, San Francisco
Why Is Anthony Y. H. Lu Influential?
(Suggest an Edit or Addition)Anthony Y. H. Lu's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. (1984) (1040)
- Inhibition and Induction of Cytochrome P450 and the Clinical Implications (1998) (830)
- Role of pharmacokinetics and metabolism in drug discovery and development. (1997) (639)
- Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes. (1995) (638)
- Multiplicity of mammalian microsomal cytochromes P-45. (1979) (574)
- Glutathione S-transferases: gene structure, regulation, and biological function. (1989) (568)
- Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes. (1968) (527)
- Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components. (1969) (508)
- Pharmacogenetics, Pharmacogenomics, and Individualized Medicine (2011) (437)
- Phosphatidylcholine requirement in the enzymatic reduction of hemoprotein P-450 and in fatty acid, hydrocarbon, and drug hydroxylation. (1970) (385)
- Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes. (1976) (306)
- Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations. (1972) (304)
- Interindividual variability in inhibition and induction of cytochrome P450 enzymes. (2001) (282)
- Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent. (2000) (250)
- Partial purification of cytochromes P-450 and P-448 from rat liver microsomes. (1972) (238)
- Multiple forms of rat liver cytochrome P-450. Immunochemical evidence with antibody against cytochrome P-448. (1976) (237)
- Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides. (1976) (232)
- CYP1A Induction and Human Risk Assessment: An Evolving Tale of in Vitro and in Vivo Studies (2007) (216)
- Lipid peroxidation and the degradation of cytochrome P-450 heme. (1973) (207)
- Effects of inducers and epoxide hydrase on the metabolism of benzo(a)pyrene by liver microsomes and a reconstituted system: analysis by high pressure liquid chromatography. (1974) (197)
- The resolution and reconstitution of the liver microsomal hydroxylation system. (1974) (196)
- Biotransformation of lovastatin. IV. Identification of cytochrome P450 3A proteins as the major enzymes responsible for the oxidative metabolism of lovastatin in rat and human liver microsomes. (1991) (195)
- Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides. (1976) (190)
- The environmental impact of the use of ivermectin: environmental effects and fate (1989) (183)
- Rat liver glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital. (1984) (178)
- Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay. (1986) (170)
- Pregnenolone-16 -carbonitrile: a new type of inducer of drug-metabolizing enzymes. (1972) (160)
- Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. IX. The formation of a 455-nm metabolite-cytochrome P-450 complex. (1971) (158)
- Molecular properties and biological functions of microsomal epoxide hydrase. (1980) (156)
- Human cytochrome P450 3A4-catalyzed testosterone 6 beta-hydroxylation and erythromycin N-demethylation. Competition during catalysis. (1997) (154)
- Metabolism of benzo[a]pyrene. Effect of substrate concentration and 3-methylcholanthrene pretreatment on hepatic metabolism by microsomes from rats and mice. (1975) (145)
- Acetone-inducible cytochrome P-450: purification, catalytic activity, and interaction with cytochrome b5. (1986) (139)
- Separation, purification, and properties of multiple forms of cytochrome P-450 from the liver microsomes of phenobarbital-treated mice. (1976) (136)
- Hydroxylation of benzphetamine and other drugs by a solubilized form of cytochrome P-450 from liver microsomes: lipid requirement for drug demethylation. (1969) (132)
- Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity (2011) (128)
- Multiple forms of cytochrome P-450 in phenobarbital- and 3-methylcholanthrene-treated rats. Separation and spectral properties. (1975) (124)
- Liver microsomal expoxide hydrase. Solubilization, purification, and characterization. (1975) (124)
- A simple and rapid procedure for the purification of phenobarbitalinducible cytochrome P-450 from rat liver microsomes (1979) (123)
- Studies on the association of cytochrome P-450 and NADPH-cytochrome c reductase during catalysis in a reconstituted hydroxylating system. (1979) (121)
- Immunochemical evidence for six forms of rat liver cytochrome P450 obtained using antibodies against purified rat liver cytochromes P450 and P448. (1976) (121)
- Preparation of partially purified, lipid-depleted cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase from rat liver microsomes. (1974) (120)
- Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VI. Different substrate specificities of the cytochrome P450 fractions from control and phenobarbital-treated rats. (1973) (110)
- Mutagenicity of metabolically activated benzo[a]anthracene 3,4-dihydrodiol: evidence for bay region activation of carcinogenic polycyclic hydrocarbons. (1976) (107)
- Properties of a solubilized form of the cytochrome P-450-containing mixed-function oxidase of liver microsomes. (1970) (106)
- Rat liver glutathione S-transferases. Construction of a cDNA clone complementary to a Yc mRNA and prediction of the complete amino acid sequence of a Yc subunit. (1985) (105)
- Role of cytochrome b5 in hydroxylation by a reconstituted cytochrome P-450-containing system. (1974) (100)
- Studies on the rate-limiting enzyme component in the microsomal monooxygenase system. Incorporation of purified NADPH-cytochrome c reductase and cytochrome P-450 into rat liver microsomes. (1978) (97)
- Allosteric behavior in cytochrome p450-dependent in vitro drug-drug interactions: a prospective based on conformational dynamics. (2001) (96)
- Chapter 7 – Reactions Catalyzed by the Cytochrome P-450 System (1980) (93)
- Cytochrome P450 in vitro reaction phenotyping: a re-evaluation of approaches used for P450 isoform identification. (2003) (92)
- METABOLISM-BASED DRUG-DRUG INTERACTIONS: WHAT DETERMINES INDIVIDUAL VARIABILITY IN CYTOCHROME P450 INDUCTION? (2005) (91)
- The direct oxidation of ethanol by a catalase- and alcohol dehydrogenase-free reconstituted system containing cytochrome P-4501. (1978) (89)
- Identification of epoxide hydrase as the preneoplastic antigen in rat liver hyperplastic nodules. (1978) (88)
- Liver microsomal epoxide hydrase. (1977) (87)
- Rat liver glutathione S-transferases. Nucleotide sequence analysis of a Yb1 cDNA clone and prediction of the complete amino acid sequence of the Yb1 subunit. (1985) (82)
- The catalytic mechanism of glutathione S-transferase (GST). Spectroscopic determination of the pKa of Tyr-9 in rat alpha 1-1 GST. (1993) (80)
- Selective inactivation of cytochrome P-450 isozymes by suicide substrates. (1981) (79)
- Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. The oxidative O-dealkylation of 7-ethoxycoumarin. (1984) (77)
- Electroimmunochemical quantitation of cytochrome P-450, cytochrome P-448, and epoxide hydrolase in rat liver microsomes. (1981) (76)
- Metabolism of dietary polyphenols and possible interactions with drugs. (2007) (73)
- Environmental Aspects of Ivermectin Usage in Livestock: General Considerations (1989) (73)
- Metabolism of benzo[a]pyrene. III. An evaluation of the fluorescence assay. (1975) (70)
- Carcinogenicity and mutagenicity of the 3,4-dihydrodiols and other metabolites of 7,12-dimethylbenz(a)anthracene and its hydroxymethyl derivatives. (1980) (70)
- Kinetic isotope effects in cytochrome P-450-catalyzed oxidation reactions. Intermolecular and intramolecular deuterium isotope effects during the N-demethylation of N,N-dimethylphentermine. (1980) (69)
- Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. VII. Stimulation of benzphetamine N-demethylation by lipid and detergent. (1974) (68)
- Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective (2010) (68)
- Multiplicity of liver drug metabolizing enzymes. (1979) (67)
- Rat liver glutathione S-transferases. DNA sequence analysis of a Yb2 cDNA clone and regulation of the Yb1 and Yb2 mRNAs by phenobarbital. (1986) (66)
- Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. Evidence for the irreversible formation of an activated oxygen intermediate of cytochrome P-448. (1984) (66)
- Rat liver cytosolic azoreductase. Electron transport properties and the mechanism of dicumarol inhibition of the purified enzyme. (1979) (66)
- Rat liver cytosolic azoreductase. Purification and characterization. (1979) (66)
- Purification of liver microsomal cytochrome P-448 from 3-methylcholanthrene-treated rabbits. (1975) (65)
- The association of cytochrome P-450 and NADPH-cytochrome P-450 reductase in phospholipid membranes. (1984) (65)
- Drug-metabolism research challenges in the new millennium: individual variability in drug therapy and drug safety. (1998) (65)
- Reconstituted mammalian mixed-function oxidases: Requirements, specificities and other properties (1978) (64)
- Stereospecificity of microsomal and purified epoxide hydrase from rat liver. Hydration of arene oxides of polycyclic hydrocarbons. (1977) (64)
- Accessibility of cytochrome P450 in microsomal membranes: inhibition of metabolism by antibodies to cytochrome P450. (1977) (63)
- Partial purification and properties of cytochromes P-450 and P-448 from rat liver microsomes. (1972) (62)
- Pharmacogenomics and Individualized Medicine (2012) (61)
- Rat liver NAD(P)H:quinone reductase. Construction of a quinone reductase cDNA clone and regulation of quinone reductase mRNA by 3-methylcholanthrene and in persistent hepatocyte nodules induced by chemical carcinogens. (1986) (60)
- Metabolism of benzo[a]pyrene. Effect of 3-methylcholanthrene pretreatment on metabolism by microsomes from lungs of genetically "responsive" and "nonresponsive" mice. (1977) (60)
- Effect of enzyme inducers on substrate specificity of the cytochrome P-450's. (1973) (59)
- Metabolism and Tissue Residues (1989) (58)
- A reconstituted microsomal enzyme system that converts naphthalene to trans-1,2-dihydroxy-1,2-dihydronaphthalene via naphthalene-1,2-oxide: presence of epoxide hydrase in cytochrome P-450 and P-448 fractions. (1972) (58)
- Hepatic microsomal epoxide hydrase. Involvement of a histidine at the active site suggests a nucleophilic mechanism. (1978) (57)
- [11] Purification of cytochrome P-450 and P-448 from rat liver microsomes (1978) (56)
- Site-directed mutagenesis of glutathione S-transferase YaYa. Important roles of tyrosine 9 and aspartic acid 101 in catalysis. (1992) (56)
- Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation. (2004) (55)
- Identification of a glycine-rich sequence as an NAD(P)H-binding site and tyrosine 128 as a dicumarol-binding site in rat liver NAD(P)H:quinone oxidoreductase by site-directed mutagenesis. (1992) (55)
- Comparative in vivo and in vitro metabolism of ivermectin in steers, sheep, swine, and rat. (1987) (55)
- Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VIII. Different catalytic activities of rabbit and rat cytochromes P-448. (1972) (54)
- Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. 3. Properties of the reconstituted 3,4-benzypyrene hydroxylase system. (1972) (50)
- The rate of pentobarbital and acetanilide metabolism by liver microsomes: a function of lipid peroxidation and degradation of cytochrome P-450 heme. (1973) (49)
- Metabolism of trans-9,10-dihydroxy-9,10-dihydrobenzo[a]pyrene occurs primarily by arylhydroxylation rather than formation of a diol epoxide. (1978) (49)
- Rat liver NAD(P)H: quinone reductase nucleotide sequence analysis of a quinone reductase cDNA clone and prediction of the amino acid sequence of the corresponding protein. (1987) (48)
- Aldrin epoxidation catalyzed by purified rat-liver cytochromes P-450 and P-448. High selectivity for cytochrome P-450. (1980) (48)
- Studies on the stimulation of cytochrome P-450-dependent monooxygenase activity by dilauroylphosphatidylcholine. (1981) (48)
- Liver microsomal electron transport systems. III. The involvement of cytochrome b5 in the NADPH-supported cytochrome P-450-dependent hydroxylation of chlorobenzene. (1974) (48)
- IDENTIFICATION OF CRITICAL AMINO ACID RESIDUES OF HUMAN CYP2A13 FOR THE METABOLIC ACTIVATION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE, A TOBACCO-SPECIFIC CARCINOGEN (2004) (46)
- A low-temperature EPR study of partially purified, soluble ferric cytochromes P-450 and P-448 from rat liver microsomes. (1973) (46)
- Tumor-initiating ability of the twelve monomethylbenz[a]anthracenes. (1982) (45)
- Liver microsomal electron transport systems. II. The involvement of cytochrome b5 in the NADH-dependent hydroxylation of 3,4-benzpyrene by a reconstituted cytochrome P-448-containing system. (1974) (45)
- Role of Purified Cytochrome P-448 and Epoxide Hydrase in the Activation and Detoxification of Benzo[a]pyrene (1977) (44)
- Regulation of glutathione transferase and DT-diaphorase mRNAs in persistent hepatocyte nodules during chemical hepatocarcinogenesis. (1984) (42)
- Kinetic isotope effects and ‘metabolic switching’ in cytochrome P450‐catalyzed reactions (1987) (41)
- Origins of individual variability in P4501A induction. (2003) (41)
- Purification of human liver microsomal epoxide hydrase. Differences in the properties of the human and rat enzymes. (1979) (40)
- Utility of recombinant cytochrome p450 enzymes: a drug metabolism perspective. (2005) (38)
- Liver microsomal epoxide hydrase: activation, inhibition, and immunological properties of the purified enzyme. (1978) (38)
- Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. V. Competition between cytochromes P-450 and P-448 for reductase in 3,4-benzpyrene hydroxylation. (1972) (37)
- The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters. (2008) (36)
- Reconstitution of the reduced nicotinamide adenine dinucleotide phosphate- and reduced nicotinamide adenine dinucleotide-peroxidase activities from solubilized components of rat liver microsomes. (1975) (36)
- Organic solvent extraction of liver microsomal lipid. I. The requirement of lipid for 3,4-benzpyrene hydroxylase. (1974) (36)
- Assay and partial purification of epoxide hydrase from rat liver microsomes. (1974) (36)
- The metabolism of avermectins B1a, H2B1a, and H2B1b by liver microsomes. (1982) (34)
- Hydration of arene and alkene oxides by epoxide hydrase in human liver microsomes (1977) (34)
- Drug residue formation from ronidazole, a 5-nitroimidazole. I. Characterization of in vitro protein alkylation. (1982) (34)
- Drug residue formation from ronidazole, a 5-nitroimidazole. V. Cysteine adducts formed upon reduction of ronidazole by dithionite or rat liver enzymes in the presence of cysteine. (1984) (32)
- Drug residue formation from ronidazole, a 5-nitroimidazole. III. Studies on the mechanism of protein alkylation in vitro. (1982) (32)
- Differential induction of rat hepatic cytochrome P-448 and glutathione S-transferase B messenger RNAs by 3-methylcholanthrene. (1982) (32)
- Rat liver glutathione S-transferase B: the functional mRNAs specific for the Ya Yc subunits are induced differentially by phenobarbital. (1982) (31)
- Contributions of thiolate "desolvation" to catalysis by glutathione S-transferase isozymes 1-1 and 2-2: evidence from kinetic solvent isotope effects (1991) (30)
- Inhibition by CO of hepatic benzo[a]pyrene hydroxylation and its reversal by monochromatic light. (1977) (28)
- The metabolism of avermectin-H2B1a and -H2B1b by pig liver microsomes. (1984) (28)
- Drug residue formation from ronidazole, a 5-nitroimidazole. II. Involvement of microsomal NADPH-cytochrome P-450 reductase in protein alkylation in vitro. (1982) (27)
- Organic Solvent Extraction of Liver Microsomal Lipid: II. Effect on the Metabolism of Substrates and Binding Spectra of Cytochrome P-450 (1974) (27)
- Hepatic microsomal epoxide hydrase. Chemical evidence for a single polypeptide chain. (1979) (27)
- CYP 1 A Induction and Human Risk Assessment : An Evolving Tale of in Vitro and in Vivo Studies (2007) (26)
- Inhibitory anti-peptide antibody against human CYP3A4. (1997) (25)
- Characterization of partially purified cytochromes P-450 and P-448 from rat liver microsomes. (1973) (25)
- Induction of rat liver cytosol methyl red azo-reductase by 3-methylcholanthrene assayed by a sensitive fluorometric method. (1978) (25)
- Ligand effects on the fluorescence properties of tyrosine-9 in alpha 1-1 glutathione S-transferase. (1996) (25)
- Structural requirements for the metabolic activation of benzo[a]pyrene to mutagenic products: effects of modifications in the 4,5-, 7,8-, and 9,10-positions. (1977) (24)
- Tumorigenicity of 7,12-dimethylbenz[a]anthracene, its hydroxymethylated derivatives and selected dihydrodiols in the newborn mouse. (1981) (23)
- Rate-limiting steps in cytochrome P-450-catalysed reactions: studies on isotope effects in the O-de-ethylation of 7-ethoxycoumarin. (1984) (22)
- The 1996 Bernard B. Brodie lecture: A journey in cytochrome P450 and drug metabolism research. (1998) (22)
- Inhibitory anti-CYP3A4 peptide antibody: mapping of inhibitory epitope and specificity toward other CYP3A isoforms. (1999) (21)
- Rat liver DT-diaphorase: regulation of functional mRNA levels by 3-methylcholanthrene, trans-stilbene oxide, and phenobarbital. (1984) (21)
- Comparison of cytochromes P-450 with high activity toward benzo[a]pyrene purified from liver microsomes of beta-naphthoflavone and 3-methylcholanthrene-pretreated rats. (1982) (21)
- Multiplicity of liver microsomal cytochrome P-450: separation, purification and characterization. (1975) (21)
- Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions: full expression of the intrinsic isotope effect during the O-deethylation of 7-ethoxycoumarin by liver microsomes from 3-methylcholanthrene-induced hamsters. (1985) (21)
- Drug residue formation from ronidazole, a 5-nitroimidazole. VI. Lack of mutagenic activity of reduced metabolites and derivatives of ronidazole. (1984) (20)
- Production of hydroxyl radicals and their role in the oxidation of ethanol by a reconstituted microsomal system containing cytochrome P-450 purified from phenobarbital-treated rats. (1979) (20)
- Induction of translationally active rat liver glutathione S-transferase B messenger RNA by phenobarbital. (1981) (20)
- The environmental safety of ivermectin: An overview (1989) (19)
- The Liver Microsomal Hydroxylation Enzyme System (1976) (19)
- Role of isozymes of cytochrome P-450 in the metabolism of N,N-dimethyl-4-aminoazobenzene in the rat. (1982) (18)
- Liver microsomal electron transport systems. Properties of a reconstituted, NADH-mediated benzo[a]pyrene hydroxylation system. (1977) (18)
- Metabolic disposition of ivermectin in swine (1990) (18)
- Drug metabolism and pharmacokinetics in support of drug design. (2009) (18)
- Site-directed mutagenesis of glutathione S-transferase YaYa: nonessential role of histidine in catalysis. (1991) (17)
- Expression of a cDNA encoding a rat liver glutathione S-transferase Ya subunit in Escherichia coli. (1989) (17)
- Site-directed mutagenesis of glutathione S-transferase YaYa. Mapping the glutathione-binding site. (1993) (17)
- The metabolic activation of ronidazole [(1-methyl-5-nitroimidazole-2-yl)-methyl carbamate] to reactive metabolites by mammalian, cecal bacterial and T. foetus enzymes. (1986) (16)
- Subunit functional studies of NAD(P)H:quinone oxidoreductase with a heterodimer approach. (1995) (16)
- FATTY ACID ω-OXIDATION IN A SOLUBLE MICROSOMAL ENZYME SYSTEM CONTAINING P-450* (1969) (16)
- Drug residue formation from ronidazole, a 5-nitroimidazole. VIII. Identification of the 2-methylene position as a site of protein alkylation. (1992) (15)
- CHARACTERIZATION OF MULTIPLE FORMS OF HIGHLY PURIFIED CYTOCHROME P-450 FROM THE LIVER MICROSOMES OF RATS, MICE AND RABBITS (1977) (15)
- Purification and assay of liver microsomal epoxide hydrase. (1978) (15)
- Role of sulfhydryl gropus in the hydroxylation of benzo[a]pyrene by purified rat and rabbit cytochrome P-448. (1977) (15)
- Biotransformation of lovastatin--III. Effect of cimetidine and famotidine on in vitro metabolism of lovastatin by rat and human liver microsomes. (1990) (15)
- The Topology of the Mammalian Cytochrome P-450 Active Site (1986) (14)
- Fluorescence characterization of Trp 21 in rat glutathione S‐transferase 1–1: Microconformational changes induced by S‐hexyl glutathione (1993) (14)
- Multiple Ya subunits of glutathione S-transferase detected by monoclonal antibodies. (1986) (14)
- Effect of phenobarbital on the level of translatable rat liver epoxide hydrolase mRNA. (1981) (14)
- Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. IV. Hydroxylation of aniline. (1972) (14)
- The importance of cytochrome P-450 and P-448 in determining the specificity of the reconstituted liver microsomal hydroxylation system. (1971) (13)
- Drug residue formation from ronidazole, a 5-nitroimidazole. VII. Comparison of protein-bound products formed in vitro and in vivo. (1984) (13)
- Coordinate induction of multiple mRNAs specific for rat liver phenobarbital-inducible cytochromes P-450. (1983) (13)
- Site-directed mutagenesis of glutathione S-transferase YaYa: functional studies of histidine, cysteine, and tryptophan mutants. (1992) (12)
- The effect of altering liver microsomal co-binding hemoprotein composition on pentobarbital-induced anesthesia. (1972) (12)
- Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. I. Determination of substrate specificity by the cytochrome P-450 and P-448 fractions. (1971) (12)
- Antibodies as a Probe in Cytochrome P450 Research (2009) (12)
- Regulation of expression of rat liver glutathione S-transferases: xenobiotic and antioxidant induction of the Ya subunit gene (1994) (12)
- Tissue drug residues and their toxicological significance. (1987) (11)
- Liver microsomal drug-metabolizing enzyme system: functional components and their properties. (1976) (11)
- Expression of mammalian DT-diaphorase in Escherichia coli: purification and characterization of the expressed protein. (1990) (11)
- Regulation of glutathione S-transferase mRNAs by phenobarbital and 3-methylcholanthrene: analysis using cDNA probes. (1984) (11)
- The liver microsomal hydroxylation enzyme system. Induction and properties of the functional components. (1976) (11)
- Site-directed mutagenesis of rat liver NAD(P)H: quinone oxidoreductase: roles of lysine 76 and cysteine 179. (1992) (10)
- In vitro studies on the interaction of famotidine with liver microsomal cytochrome P-450. (1988) (10)
- A simple and rapid procedure for the purification of phenobarbital-inducible cytochrome P-450 from rat liver microsomes. (1979) (10)
- Isolation and characterization of a DNA sequence complementary to rat liver glutathione S-transferase B mRNA. (1983) (9)
- Purification of cytochrome P-450 and P-448 from rat liver microsomes. (1978) (8)
- Chapter 30. Inhibition of Cytochrome P-450 and Implications in Drug Development (1997) (8)
- Drug residue formation from ronidazole, a 5-nitro-imidazole. IV. The role of the microflora. (1983) (8)
- Role of cytochrome b5 in NADPH-and NADH-dependent hydroxylation by the reconstituted cytochrome P-450- or P-448-containing system. (1975) (8)
- Liver microsomal DT diaphorase: noninvolvement in hydroxylation of benzo(a)pyrene. (1977) (7)
- NADPH-Dependent Cytochrome P450 Reductase (1991) (7)
- Partial purification and separation of multiple forms of cytochrome. P-450 and cytochrome P-448 from rat liver microsomes. (1975) (6)
- Perspective CYP1A Induction and Human Risk Assessment: An Evolving Tale of in Vitro and in Vivo Studies (2007) (6)
- Drug‐metabolizing Enzymes: A Group of Promiscuous Catalysts (2014) (6)
- Roles of histidine-194, aspartate-163, and a glycine-rich sequence of NAD(P)H:quinone oxidoreductase in the interaction with nicotinamide coenzymes. (1995) (6)
- Development of a unified approach to evaluate the toxicological potential of bound residues. (1990) (6)
- Cell-free synthesis of epoxide hydrase by liver poly (A+)-RNA isolated from phenobarbital treated rats. (1980) (5)
- Studies on the spin state of 3-methylcholanthrene induced cytochrome P-450 from rat liver. (1975) (5)
- Tumor-initiating activity of the dihydrodiols of 8-methylbenz[a]anthracene and 8-hydroxymethylbenz[a]anthracene. (1981) (4)
- Kinetic Isotope Effects on Cytochrome P-450-catalyzed Oxidation Reactions (2001) (4)
- Problems associated with the use of cycloheximide to distinguish between animal drug residues bound to protein and those incorporated into protein. (1982) (4)
- IV. Identification of Cytochrome P450 3A Proteins as the Major Enzymes Responsible for the Oxidative Metabolism of Lovastatin in Rat and Human Liver Microsomes (1991) (4)
- EVIDENCE FOR THE DIRECT INVOLVEMENT OF HEPATIC CYTOCHROME P450 IN ETHANOL METABOLISM (1977) (4)
- Studies on the mechanism of activation and the mutagenicity of ronidazole, a 5-nitroimidazole. (1986) (4)
- Specificity of antisera directed against rat liver cytochrome P-448. (1974) (4)
- n-Octylamine difference spectra of cytochromes P-450 and P-448 from rat and mouse liver: a species difference. (1973) (4)
- Structure-genotoxicity relationship for aliphatic epoxides (1983) (4)
- Mechanism of metabolic activation of ronidazole, a 5-nitroimidazole. (1984) (4)
- Formation and biological evaluation of ronidazole bound residues. (1990) (4)
- Isolation and characterization of monoclonal antibodies against rat liver epoxide hydrolase. (1983) (3)
- Application of carbonic anhydrase affinity chromatography in study of tissue-bound residue of 4-amino-6-trichloroethenyl-1,3-benzenedisulfonamide (MK-401, clorsulon). (1985) (3)
- Separation and purification of multiple forms of cytochrome p-450 from liver microsomes of phenobarbital-treated mice. Abstr. (1976) (3)
- KINETIC ISOTOPE EFFECTS IN CYTOCHROME P-450-CATALYZED OXIDATION REACTIONS. I. SUBSTRATE - CYTOCHROME P-450 INTERACTIONS (1980) (3)
- Activating enzymes: multiple monooxygenase forms with different substrate preferences as related to toxic effects. (1980) (3)
- ON THE STIMULATORY ROLE OF PHOSPHATIDYLCHOLINE IN A CYTOCHROME P-450-CONTAINING RECONSTITUTED HYDROXYLATION SYSTEM (1980) (2)
- Expression in Escherichia coli of rat liver cytosolic glutathione S-transferase Yc cDNA. (1990) (2)
- Kinetic Isotope Effects in Cytochrome P-450-Catalyzed Oxidation Reactions. II. Interactions of Cytochrome P-450 with Substrates and Nadph-Cytochrome % MathType!MTEF!2!1!+-% feaagCart1ev2aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr% 4rNCHbGeaGqiVu0 (1980) (1)
- In-vitro Drug Metabolism Studies During Development of New Drugs (2004) (1)
- Chapter 22. Molecular Aspects of Drug Metabolism (1978) (1)
- Mechanism of Metabolic Activation of Nitroimidazoles (1991) (1)
- ANTHONY Y. H. LU COMMEMORATIVE ISSUE DRUG-METABOLISM RESEARCH CHALLENGES IN THE NEW MILLENNIUM Individual Variability in Drug Therapy and Drug Safety (1998) (1)
- NADPH-cytochrome P-450 reductase is not a component of the liver microsomal steroid 5-alpha reductase. (1989) (1)
- Therapeutic Agents and Cytochrome P450 (1995) (1)
- Kinetic isotope effects in cytochrome P-450-catalyzed oxidation reactions. II. Interactions of cytochrome P-450 with substrates and NADPH-cytochrome C reductase. (1980) (0)
- Expression of a cDNA encoding rat liver DT-diaphorase in Escherichia coli. (1991) (0)
- Studies on the role of nitro group reduction in the chemical activation of ronidazole, a 5-nitro-imidazole (1986) (0)
- TISSUE DRUG RESIDUES AND THEIR (1987) (0)
- STUDIES ON THE SITE OF FLUORESCAMINE INHIBITION OF CYTOCHROME P-450-MEDIATED REACTIONS (1980) (0)
- SYNTHESIS OF CYTOCHROME P-450 DIRECTED BY RAT LIVER RNA ISOLATED SUBSEQUENT TO PHENOBARBITAL ADMINISTRATION (1980) (0)
- Critical Amino Acid Residues for Nicotine 5′-Hydroxylation in Human CYP2A Enzymes (2008) (0)
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