Adelbert Bacher

Adelbert Bacher's AcademicInfluence.com Rankings

Adelbert Bacher

Chemistry

#2934

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#3910

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Chemistry

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Adelbert Bacher's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Analysis of a chemical plant defense mechanism in grasses. (1997) (632)
Biosynthesis of isoprenoids via the non-mevalonate pathway (2004) (612)
Deoxyxylulose phosphate pathway to terpenoids. (2001) (474)
The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganisms. (1998) (403)
Terpenoid biosynthesis from 1-deoxy-D-xylulose in higher plants by intramolecular skeletal rearrangement. (1997) (367)
Studies on the nonmevalonate terpene biosynthetic pathway: Metabolic role of IspH (LytB) protein (2002) (342)
Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol. (1999) (249)
Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin. (1996) (243)
Biosynthesis of vitamin b2 (riboflavin). (2000) (236)
Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate. (2000) (233)
Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (2000) (212)
The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: Studies on the mechanisms of the reactions catalyzed by IspG and IspH protein (2003) (205)
Studies on the nonmevalonate pathway to terpenes: The role of the GcpE (IspG) protein (2001) (202)
Biosynthesis of riboflavin. (2001) (192)
The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates. (2001) (183)
Biosynthesis of flavocoenzymes. (2005) (162)
Biosynthesis of cannabinoids (2001) (161)
X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 A resolution: determinants of thermostability revealed from structural comparisons. (2001) (161)
Biosynthesis of terpenes: Studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (2002) (153)
Structural Basis of Fosmidomycin Action Revealed by the Complex with 2-C-Methyl-d-erythritol 4-phosphate Synthase (IspC) (2003) (149)
Quantitative assessment of crosstalk between the two isoprenoid biosynthesis pathways in plants by NMR spectroscopy (2004) (145)
Monoterpenoid essential oils are not of mevalonoid origin (1997) (134)
Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. (2010) (133)
Carbon metabolism of Listeria monocytogenes growing inside macrophages (2008) (130)
Heavy riboflavin synthase from Bacillus subtilis. Crystal structure analysis of the icosahedral beta 60 capsid at 3.3 A resolution. (1988) (129)
Biosynthesis of cannabinoids. Incorporation experiments with (13)C-labeled glucoses. (2001) (122)
On the reaction mechanism of adduct formation in LOV domains of the plant blue-light receptor phototropin. (2004) (120)
Zinc plays a key role in human and bacterial GTP cyclohydrolase I. (2000) (119)
Magnetic-field effect on the photoactivation reaction of Escherichia coli DNA photolyase (2008) (118)
Active site topology and reaction mechanism of GTP cyclohydrolase I. (1995) (116)
A Bicyclic Autotrophic CO2 Fixation Pathway inChloroflexus aurantiacus * (2002) (116)
Isoprenoid biosynthetic pathways as anti-infective drug targets. (2005) (115)
Biosynthesis of hyperforin in Hypericum perforatum. (2002) (115)
Advances of high-resolution NMR techniques in the structural and metabolic analysis of plant biochemistry. (2007) (113)
Atomic structure of GTP cyclohydrolase I. (1995) (112)
A metastable prerequisite for the growth of lumazine synthase crystals. (2005) (109)
IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis. (2004) (109)
Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana. (2000) (108)
GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase are rate-limiting enzymes in riboflavin synthesis of an industrial Bacillus subtilis strain used for riboflavin production (1999) (106)
Biosynthesis of riboflavin: characterization of the bifunctional deaminase-reductase of Escherichia coli and Bacillus subtilis (1997) (104)
Biosynthesis of terpenoids: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from tomato. (2000) (102)
Studies on the lumazine synthase/riboflavin synthase complex of Bacillus subtilis: crystal structure analysis of reconstituted, icosahedral beta-subunit capsids with bound substrate analogue inhibitor at 2.4 A resolution. (1995) (101)
Pathogenomics of Listeria spp. (2007) (100)
Probing the reaction mechanism of IspH protein by x-ray structure analysis (2009) (100)
Biosynthesis of riboflavin: cloning, sequencing, and expression of the gene coding for 3,4-dihydroxy-2-butanone 4-phosphate synthase of Escherichia coli (1992) (98)
Retrobiosynthetic NMR Studies with 13C-Labeled Glucose (1997) (97)
Riboflavin synthases of Bacillus subtilis. Purification and properties. (1980) (96)
Biosynthesis of riboflavin: cloning, sequencing, mapping, and expression of the gene coding for GTP cyclohydrolase II in Escherichia coli (1993) (94)
The 1.25 Å crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters (1997) (93)
Elucidation of novel biosynthetic pathways and metabolite flux patterns by retrobiosynthetic NMR analysis (1998) (93)
13C-NMR study of autotrophic CO2 fixation pathways in the sulfur-reducing Archaebacterium Thermoproteus neutrophilus and in the phototrophic Eubacterium Chloroflexus aurantiacus. (1992) (91)
13C isotopologue perturbation studies of Listeria monocytogenes carbon metabolism and its modulation by the virulence regulator PrfA (2006) (91)
Folate synthesis in plants: The first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I (2002) (87)
Products of enzymatic reduction of benzoyl-CoA, a key reaction in anaerobic aromatic metabolism. (1993) (87)
Biosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-d-erythritol kinase (2003) (86)
Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. (2003) (86)
Biochemistry of the non-mevalonate isoprenoid pathway (2011) (85)
Biosynthesis of riboflavin. Studies on the reaction mechanism of 6,7-dimethyl-8-ribityllumazine synthase. (1995) (84)
Retrobiosynthetic analysis of carbon fixation in the phototrophic eubacterium Chloroflexus aurantiacus. (1993) (84)
Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids. (2002) (80)
Blue Light Perception in Plants (2003) (80)
Heavy riboflavin synthase from Bacillus subtilis. Quaternary structure and reaggregation. (1986) (78)
Studies on the 4-carbon precursor in the biosynthesis of riboflavin. Purification and properties of L-3,4-dihydroxy-2-butanone-4-phosphate synthase. (1990) (77)
Biosynthesis of vitamin B2: Structure and mechanism of riboflavin synthase. (2008) (76)
The atomic structure of pentameric lumazine synthase from Saccharomyces cerevisiae at 1.85 A resolution reveals the binding mode of a phosphonate intermediate analogue. (2000) (76)
Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction. (2009) (76)
Autotrophic CO2 Fixation by Chloroflexus aurantiacus: Study of Glyoxylate Formation and Assimilation via the 3-Hydroxypropionate Cycle (2001) (75)
Biosynthesis of gallic acid in Rhus typhina: discrimination between alternative pathways from natural oxygen isotope abundance. (2004) (75)
Biosynthesis of Riboflavin (1996) (73)
Dimethylallyl pyrophosphate is not the committed precursor of isopentenyl pyrophosphate during terpenoid biosynthesis from 1-deoxyxylulose in higher plants. (1999) (71)
Rearrangement reactions in the biosynthesis of molybdopterin (1998) (69)
Robustness of central carbohydrate metabolism in developing maize kernels. (2006) (69)
Biosynthesis of terpenoids. 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum. (2001) (68)
Biosynthesis of Flavins (1993) (67)
Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors. (2005) (67)
Control of tetrahydrobiopterin synthesis in T lymphocytes by synergistic action of interferon-gamma and interleukin-2. (1990) (67)
Riboflavin synthases of Bacillus subtilis. Purification and amino acid sequence of the alpha subunit. (1990) (66)
Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I. (2003) (66)
Auxin biosynthesis in maize kernels. (2000) (66)
Biosynthesis of riboflavin in plants. The ribA gene of Arabidopsis thaliana specifies a bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase. (2000) (66)
Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG. (2010) (65)
Thiazolopyrimidine Inhibitors of 2‐Methylerythritol 2,4‐Cyclodiphosphate Synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum (2010) (65)
The 18-kDa cytoplasmic protein of Brucella species --an antigen useful for diagnosis--is a lumazine synthase. (1999) (65)
Biosynthesis of riboflavin. Studies on the mechanism of L-3,4-dihydroxy-2-butanone 4-phosphate synthase. (1991) (64)
The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase. (2002) (63)
A Novel Pathway of Aerobic Benzoate Catabolism in the BacteriaAzoarcus evansii and Bacillus stearothermophilus* (2001) (62)
EPR, ENDOR, and TRIPLE resonance spectroscopy on the neutral flavin radical in Escherichia coli DNA photolyase. (1999) (62)
Synthesis of Nanophase Iron Oxide in Lumazine Synthase Capsids. (2001) (62)
Aerobic benzoyl‐CoA catabolic pathway in Azoarcus evansii: studies on the non‐oxygenolytic ring cleavage enzyme (2005) (62)
Biosynthesis of riboflavin. The structure of the four-carbon precursor (1988) (62)
The lumazine synthase/riboflavin synthase complex of Bacillus subtilis. X-ray structure analysis of hollow reconstituted beta-subunit capsids. (1994) (61)
Perspectives in anti-infective drug design. The late steps in the biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate. (2004) (61)
The solution structure of the N-terminal domain of riboflavin synthase. (2001) (61)
Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways. (2004) (60)
Biosynthesis of bitter acids in hops. A (13)C-NMR and (2)H-NMR study on the building blocks of humulone. (1999) (60)
New enzymes involved in aerobic benzoate metabolism in Azoarcus evansii (2004) (60)
Biosynthesis of nucleotides, flavins, and deazaflavins in Methanobacterium thermoautotrophicum. (1991) (60)
Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine. (2002) (59)
Cloning, sequencing, mapping and hyperexpression of the ribC gene coding for riboflavin synthase of Escherichia coli. (1996) (58)
Biosynthesis of vitamin B2 in plants (2006) (57)
Biosynthesis of isoprenoids: a bifunctional IspDF enzyme from Campylobacter jejuni. (2004) (56)
Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribityllumazine exomethylene anion. (2010) (54)
The deoxyxylulose phosphate pathway of isoprenoid biosynthesis. Discovery and function of the ispDEFGH genes and their cognate enzymes (2003) (54)
The lumazine synthase/riboflavin synthase complex: shapes and functions of a highly variable enzyme system (2013) (54)
Retrobiosynthetic nuclear magnetic resonance analysis of amino acid biosynthesis and intermediary metabolism. Metabolic flux in developing maize kernels. (2001) (53)
Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold. (2003) (53)
Nonaromatic Products from Anoxic Conversion of Benzoyl-CoA with Benzoyl-CoA Reductase and Cyclohexa-1,5-diene-1-carbonyl-CoA Hydratase* (2000) (53)
A comparative carbon-13, nitrogen-15, and phosphorus-31 nuclear magnetic resonance study on the flavodoxins from Clostridium MP, Megasphaera elsdenii, and Azotobacter vinelandii. (1986) (52)
Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods. (2006) (52)
A pentacyclic reaction intermediate of riboflavin synthase (2001) (52)
Starch Biosynthesis and Intermediary Metabolism in Maize Kernels. Quantitative Analysis of Metabolite Flux by Nuclear Magnetic Resonance1 (2002) (51)
Lumazine Synthase from Candida albicans as an Anti-fungal Target Enzyme (2007) (51)
Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD. (2014) (51)
A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus. (2003) (51)
Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis. (2003) (50)
Biosynthesis of riboflavin: mechanism of formation of the ribitylamino linkage. (1988) (50)
Light‐induced reactions of Escherichia coli DNA photolyase monitored by Fourier transform infrared spectroscopy (2005) (50)
Bacterial luciferase: A carbon-13, nitrogen-15 and phophorus-31 nuclear magnetic resonance investigation. (1986) (49)
Cell-free conversion of 1-deoxy-D-xylulose 5-phosphate and 2-C-methyl-D-erythritol 4-phosphate into β-carotene in higher plants and its inhibition by fosmidomycin (1999) (49)
13CO2 as a universal metabolic tracer in isotopologue perturbation experiments. (2007) (48)
Analysis of metabolic pathways via quantitative prediction of isotope labeling patterns: a retrobiosynthetic 13C NMR study on the monoterpene loganin (1999) (48)
Biosynthesis of isoprenoids. purification and properties of IspG protein from Escherichia coli. (2005) (47)
Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr). (2011) (47)
Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth. (2004) (46)
Phosphorylation of 1-deoxy-D-xylulose by D-xylulokinase of Escherichia coli. (2001) (46)
The lumazine synthase-riboflavin synthase complex of Bacillus subtilis. Crystallization of reconstituted icosahedral beta-subunit capsids. (1990) (46)
Enzymatic Synthesis of Riboflavin and FMN Specifically Labeled with 13C in the Xylene Ring (1987) (45)
Biosynthesis of terpenoids: 1‐deoxy‐D‐xylulose‐5‐phosphate reductoisomerase from Escherichia coli is a class B dehydrogenase (2000) (45)
Phosphates of riboflavin and riboflavin analogs: a reinvestigation by high-performance liquid chromatography. (1983) (45)
Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of tiboflavin synthase and lumazine synthase. (2004) (45)
Photochemically induced dynamic nuclear polarization in a C450A mutant of the LOV2 domain of the Avena sativa blue-light receptor phototropin. (2005) (44)
Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis. (2009) (44)
Formation of tight junctions in epithelial cells. I. Induction by proteases in a human colon carcinoma cell line. (1985) (44)
Histidine 179 Mutants of GTP Cyclohydrolase I Catalyze the Formation of 2-Amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone Triphosphate* (1999) (44)
g-Tensor of the Neutral Flavin Radical Cofactor of DNA Photolyase Revealed by 360-GHz Electron Paramagnetic Resonance Spectroscopy (2002) (43)
Hexameric Assembly of the Bifunctional Methylerythritol 2,4-Cyclodiphosphate Synthase and Protein-Protein Associations in the Deoxy-xylulose-dependent Pathway of Isoprenoid Precursor Biosynthesis* (2004) (43)
Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesis. (2012) (43)
Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase. (2003) (43)
Inhibitors of the herbicidal target IspD: allosteric site binding. (2011) (43)
Structure and Properties of an Engineered Transketolase from Maize1 (2003) (43)
Multiple assembly states of lumazine synthase: a model relating catalytic function and molecular assembly. (2006) (43)
Biosynthesis of riboflavin in Bacillus subtilis: function and genetic control of the riboflavin synthase complex (1978) (42)
Enoate Reductases of Clostridia (2001) (42)
Biosynthesis of riboflavin. Enzymatic formation of 6,7-dimethyl-8-ribityllumazine by heavy riboflavin synthase from Bacillus subtilis. (1986) (42)
BIOSYNTHESIS OF 2-C-METHYL-D-ERYTHRITOL IN PLANTS BY REARRANGEMENT OF THE TERPENOID PRECURSOR, 1-DEOXY-D-XYLULOSE 5-PHOSPHATE (1998) (42)
Evolution of vitamin B2 biosynthesis. A novel class of riboflavin synthase in Archaea. (2004) (41)
Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme. (1994) (41)
Studies on the nonmevalonate pathway of terpene biosynthesis. The role of 2C-methyl-D-erythritol 2,4-cyclodiphosphate in plants. (2001) (40)
Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation. (2012) (40)
Biosynthesis of riboflavin (2009) (40)
Evolution of Vitamin B2 Biosynthesis (2004) (40)
Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase. (2002) (40)
Nuphar lutea thioalkaloids inhibit the nuclear factor κappaB pathway, potentiate apoptosis and are synergistic with cisplatin and etoposide (2009) (40)
Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy. (2006) (40)
Some observations of a correlation between the symmetry of large heavy-atom complexes and their binding sites on proteins. (1987) (39)
Biosynthesis of riboflavin. Structure of the purine precursor and origin of the ribityl side chain. (1976) (39)
Riboflavin Synthase of Escherichia coli (2001) (39)
Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis. (2012) (38)
Cyclohexa‐1,5‐diene‐1‐carboxyl‐CoA hydratase, an enzyme involved in anaerobic metabolism of benzoyl‐CoA in the denitrifying bacterium Thauera aromatica (1998) (38)
Heavy riboflavin synthase from Bacillus subtilis. Particle dimensions, crystal packing and molecular symmetry. (1986) (38)
Ligand-binding studies on light riboflavin synthase from Bacillus subtilis. (2005) (38)
The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods. (2005) (38)
Folate Biosynthesis in Higher Plants. cDNA Cloning, Heterologous Expression, and Characterization of Dihydroneopterin Aldolases1[w] (2004) (38)
Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis. (2008) (38)
The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site (2001) (38)
Biosynthesis of vitamin B2. (2002) (38)
[32] Heavy riboflavin synthase from Bacillus subtilis (1986) (38)
Biosynthesis of riboflavin. Characterization of the product of the deaminase. (1981) (37)
Biosynthesis of tetrahydrofolate. Sequence of GTP cyclohydrolase I from Escherichia coli. (1991) (37)
Carbon-13 and nitrogen-15 nuclear-magnetic-resonance investigation on Desulfovibrio vulgaris flavodoxin. (1985) (37)
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe. (2002) (37)
Biosynthesis of riboflavin: an unusual riboflavin synthase of Methanobacterium thermoautotrophicum (1997) (37)
Ultrafast infrared spectroscopy of an isotope-labeled photoactivatable flavoprotein. (2011) (37)
Probing the N(5)-H bond of the isoalloxazine moiety of flavin radicals by X- and W-band pulsed electron-nuclear double resonance. (2005) (36)
Biosynthesis of riboflavin. Incorporation of 13C-labeled precursors into the xylene ring. (1985) (36)
QUANTITATIVE ASSESSMENT OF METABOLIC FLUX BY 13C NMR ANALYSIS. BIOSYNTHESIS OF ANTHRAQUINONES IN RUBIA TINCTORUM (1999) (36)
Discovery of acetylene hydratase activity of the iron–sulphur protein IspH (2012) (36)
Changes in flux pattern of the central carbohydrate metabolism during kernel development in maize. (2005) (36)
Nonphosphate Inhibitors of IspE Protein, a Kinase in the Non‐Mevalonate Pathway for Isoprenoid Biosynthesis and a Potential Target for Antimalarial Therapy (2007) (36)
Biosynthesis of riboflavin. The reaction catalyzed by 6,7-dimethyl-8-ribityllumazine synthase can proceed without enzymatic catalysis under physiological conditions. (2001) (36)
Determination of the Chemical Structure of Linden Ether (1990) (35)
Isoprenoid biosynthesis in plants – 2C‐methyl‐d‐erythritol‐4‐phosphate synthase (IspC protein) of Arabidopsis thaliana (2006) (35)
Solution structures of 6,7-dimethyl-8-substituted-lumazines. Carbon-13 NMR evidence for intramolecular ether formation (1986) (35)
IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters. (2013) (35)
Cloning, sequencing and functional studies of the gene encoding human GTP cyclohydrolase I. (1996) (34)
Biosynthetic precursors of deazaflavins (1992) (34)
Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase – ligand recognition in a template for antimicrobial drug discovery (2008) (34)
Investigation of the Binding of Fluorolumazines to the 1-MDa Capsid of Lumazine Synthase by 15N{19F} REDOR NMR (1999) (33)
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis (2006) (33)
15N- and 13C-NMR investigations of glucose oxidase from Aspergillus niger. (1991) (33)
Elucidation of biosynthetic pathways by retrodictive/predictive comparison of isotopomer patterns determined by NMR spectroscopy. (2000) (32)
Species and tissue specificity of mammalian GTP cyclohydrolase I messenger RNA. (1992) (32)
Crystal Structure of an Archaeal Pentameric Riboflavin Synthase in Complex with a Substrate Analog Inhibitor (2006) (32)
BIOSYNTHESIS OF VITAMIN B 2 (RIBOFLAVIN) (2000) (32)
Mimicking Tissue Surfaces by Supported Membrane Coupled Ultrathin Layer of Hyaluronic Acid (2003) (32)
Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii. (2006) (31)
Biosynthesis of terpenes. Preparation of (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate, an intermediate of the deoxyxylulose phosphate pathway. (2002) (31)
Biosynthesis of the Diterpene Verrucosan-2β-ol in the Phototrophic Eubacterium Chloroflexus aurantiacus (1998) (31)
Isotopolog perturbation techniques for metabolic networks: metabolic recycling of nutritional glucose in Drosophila melanogaster. (2004) (31)
Biosynthesis of thiophenes in Tagetes patula. (2001) (31)
Fluorine-19 NMR studies on the mechanism of riboflavin synthase. Synthesis of 6-(trifluoromethyl)-7-oxo-8-(D-ribityl)lumazine and 6-(trifluoromethyl)-7-methyl-8-(D-ribityl)lumazine (1992) (31)
Evolution of Vitamin B2 Biosynthesis: 6,7-Dimethyl-8-Ribityllumazine Synthases of Brucella (2006) (31)
Synthesis of epimeric 6,7-bis(trifluoromethyl)-8-ribityllumazine hydrates. Stereoselective interaction with the light riboflavin synthase of Bacillus subtilis (1991) (30)
Biosynthesis of riboflavin: lumazine synthase and riboflavin synthase. (1997) (30)
Biosynthesis of Riboflavin (2001) (30)
Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents. (2014) (30)
Metabolic flux analysis in complex isotopolog space. Recycling of glucose in tobacco plants. (2005) (30)
Enzyme-assisted preparation of isotope-labeled 1-deoxy-d-xylulose 5-phosphate. (2001) (30)
Biosynthesis of terpenoids: efficient multistep biotransformation procedures affording isotope-labeled 2C-methyl-D-erythritol 4-phosphate using recombinant 2C-methyl-D-erythritol 4-phosphate synthase. (2001) (30)
Structural and kinetic properties of lumazine synthase isoenzymes in the order Rhizobiales. (2007) (30)
Pyrrolizidine alkaloids of the lycopsamine type: biosynthesis of trachelanthic acid (1999) (29)
DETECTION AND CHARACTERIZATION OF A LIGHT-INDUCED NEUTRAL FLAVIN RADICAL IN A C450A MUTANT OF PHOTOTROPIN* (2003) (29)
α-Substituted β-oxa isosteres of fosmidomycin: synthesis and biological evaluation. (2012) (29)
Unexpected Biosynthetic Precursors of Amarogentin − A Retrobiosynthetic 13C NMR Study (2001) (29)
Analysis of the tetrahydrobiopterin synthesizing system during maturation of murine reticulocytes (1990) (29)
Light-induced activation of class II cyclobutane pyrimidine dimer photolyases. (2010) (29)
Design, synthesis, and evaluation of 9-D-ribityl-1,3,7-trihydro-2,6,8-purinetrione, a potent inhibitor of riboflavin synthase and lumazine synthase. (2001) (29)
13C-NMR study of autotrophic CO2 fixation in Thermoproteus neutrophilus. (1989) (29)
Transcriptional regulation by antitermination. Interaction of RNA with NusB protein and NusB/NusE protein complex of Escherichia coli. (2002) (29)
Stereochemical Studies on the Making and Unmaking of Isopentenyl Diphosphate in Different Biological Systems (2004) (29)
Hindered rotation of a cofactor methyl group as a probe for protein-cofactor interaction. (2010) (29)
Domain structure of riboflavin synthase. (2001) (29)
Structural basis for the interaction of Escherichia coli NusA with protein N of phage lambda. (2004) (28)
Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase. (2005) (28)
Taxoids from Cell Cultures of Taxus Chinensis (1998) (28)
Structure of enoate reductase from a Clostridium tyrobutyricum (C. spec. La1). (1985) (28)
A new series of 3-alkyl phosphate derivatives of 4,5,6,7-tetrahydro-1-D-ribityl-1H-pyrazolo[3,4-d]pyrimidinedione as inhibitors of lumazine synthase: design, synthesis, and evaluation. (2007) (27)
NIH shift in flavin-dependent monooxygenation: mechanistic studies with 2-aminobenzoyl-CoA monooxygenase/reductase. (1999) (27)
Recent advances in riboflavin biosynthesis. (2014) (27)
Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC. (2014) (27)
Structure of 3,4-Dihydroxy-2-butanone 4-Phosphate Synthase from Methanococcus jannaschii in Complex with Divalent Metal Ions and the Substrate Ribulose 5-Phosphate (2003) (27)
The crystal structure of a plant 2C‐methyl‐D‐erythritol 4‐phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate (2006) (27)
Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans. (2004) (27)
Heavy riboflavin synthase from Bacillus subtilis. (1986) (27)
Biosynthesis of pteridines. Stopped-flow kinetic analysis of GTP cyclohydrolase I. (2001) (27)
Biosynthesis of Riboflavin in Archaea Studies on the Mechanism of 3,4-Dihydroxy-2-butanone-4-phosphate Synthase of Methanococcus jannaschii * (2002) (26)
Synthesis of tetrahydrobiopterin in Friend erythroleukemia cells and its modulator effect on cell proliferation. (1990) (26)
Rapid one-pot synthesis of riboflavin isotopomers. (2002) (26)
Enzymes from the Haloacid Dehalogenase (HAD) Superfamily Catalyse the Elusive Dephosphorylation Step of Riboflavin Biosynthesis (2013) (26)
Stimulation of Vγ9/Vδ2 T-lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate (2007) (26)
Preparation, properties, and separation by high-performance liquid chromatography of riboflavin phosphates. (1986) (26)
Biosynthesis of riboflavin: GTP cyclohydrolase II, deaminase, and reductase. (1997) (26)
Substrate binding to DNA photolyase studied by electron paramagnetic resonance spectroscopy. (2001) (26)
Anti-malarial drug targets: screening for inhibitors of 2C-methyl-D-erythritol 4-phosphate synthase (IspC protein) in Mediterranean plants. (2007) (26)
Molecular characterization of HPH-1: a mouse mutant deficient in GTP cyclohydrolase I activity. (1994) (26)
Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate. (2002) (26)
Differential incorporation of 1-deoxy-D-xylulose into monoterpenes and carotenoids in higher plants (1998) (25)
A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors. (2005) (25)
Crystallization and preliminary X-ray diffraction study of heavy riboflavin synthase from Bacillus subtilis. (1983) (25)
Evolution of vitamin B2 biosynthesis: riboflavin synthase of Arabidopsis thaliana and its inhibition by riboflavin (2005) (25)
Reductive dehydroxylation of allyl alcohols by IspH protein. (2010) (25)
Design, Synthesis, and Biological Evaluation of Homologous Phosphonic Acids and Sulfonic Acids as Inhibitors of Lumazine Synthase (1999) (25)
Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase. (2004) (25)
The structure of the N-terminal domain of riboflavin synthase in complex with riboflavin at 2.6A resolution. (2003) (24)
Femtosecond to Millisecond Dynamics of Light Induced Allostery in the Avena sativa LOV Domain. (2017) (24)
Biosynthesis of riboflavin in Bacillus subtilis: origin of the four-carbon moiety (1985) (24)
Biosynthesis of riboflavin. An aliphatic intermediate in the formation of 6,7-dimethyl-8-ribityllumazine from pentose phosphate. (1985) (24)
Biosynthesis of riboflavin: 3,4-dihydroxy-2-butanone-4-phosphate synthase. (1997) (24)
Natural abundance solution 13C NMR studies of a phototropin with photoinduced polarization. (2008) (24)
Biosynthesis of riboflavin. The structure of the purine precursor. (1973) (24)
Cloning and expression of the putative gene coding for GTP cyclohydrolase I from Escherichia coli. (1990) (24)
NMR analysis of site-specific ligand binding in oligomeric proteins. Dynamic studies on the interaction of riboflavin synthase with trifluoromethyl-substituted intermediates. (1996) (24)
A high-throughput screening platform for inhibitors of the riboflavin biosynthesis pathway. (2007) (23)
Electron microscopic observations on protein crystallization : adsorption layers, aggregates and crystal defects (2000) (23)
Structures of fluoro, amino, and thiol inhibitors bound to the [Fe4S4] protein IspH. (2013) (23)
A method for soluble overexpression of the α7 nicotinic acetylcholine receptor extracellular domain (2001) (23)
Biosynthesis of 5-hydroxybenzimidazolylcobamid (factor III) in Methanobacterium thermoautotrophicum. (1991) (23)
Flavin-protein interactions in flavocytochrome b2 as studied by NMR after reconstitution of the enzyme with 13C- and 15N-labelled flavin. (2000) (23)
A bicyclic autotrophic CO 2 fixation pathway in Chloroflexus aurantiacus (2002) (23)
Biosynthesis of riboflavin. Enzymatic formation of 6,7-dimethyl-8-ribityllumazine from pentose phosphates. (1984) (23)
Structure‐Based Design and Synthesis of the First Weak Non‐Phosphate Inhibitors for IspF, an Enzyme in the Non‐Mevalonate Pathway of Isoprenoid Biosynthesis (2007) (23)
ATP requirement for induced tight junction formation in HT 29 adenocarcinoma cells. (1987) (23)
Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase IspE of the Non‐Mevalonate Pathway for Isoprenoid Biosynthesis (2008) (23)
Problems in electronic state assignment based on circular dichroism. Optical activity of flavines and 8-substituted lumazines. (1974) (22)
Diagnosis of Toxoplasma gondii infection after allogeneic stem cell transplant can be difficult and requires intensive scrutiny (2010) (22)
Correlation of metal decoration and topochemistry on protein surfaces. (1991) (22)
A new series of N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: design, synthesis, biochemical evaluation, crystallography, and mechanistic implications. (2008) (22)
Properties of the complexes of riboflavin 3',5'-bisphosphate and the apoflavodoxins from Megasphaera elsdenii and Desulfovibrio vulgaris. (1986) (22)
The intraflavin hydrogen bond in human electron transfer flavoprotein modulates redox potentials and may participate in electron transfer. (1999) (22)
Biosynthesis of isoprenoids – studies on the mechanism of 2C‐methyl‐d‐erythritol‐4‐phosphate synthase (2008) (22)
Biosynthesis of riboflavin: structure and mechanism of lumazine synthase. (1996) (22)
Presteady State Kinetic Analysis of Riboflavin Synthase* (2003) (22)
Synthesis and Biochemical Evaluation of Bis(6,7-dimethyl-8-D-ribityllumazines) as Potential Bisubstrate Analogue Inhibitors of Riboflavin Synthase. (1999) (22)
Synthesis and Antiplasmodial Activity of Highly Active Reverse Analogues of the Antimalarial Drug Candidate Fosmidomycin (2010) (22)
Studies on the non-mevalonate isoprenoid biosynthetic pathway. Simple methods for preparation of isotope-labeled (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate (2002) (22)
Insights into the Binding of Pyridines to the Iron–Sulfur Enzyme IspH (2014) (21)
Protease inhibitors suppress the formation of tight junctions in gastrointestinal cell lines. (1992) (21)
Synthesis of 2,6-dioxo-(1H,3H)-9-N-ribitylpurine and 2,6-dioxo-(1H,3H)-8-aza-9-N-ribitylpurine as inhibitors of lumazine synthase and riboflavin synthase. (1998) (21)
Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone. A retrobiosynthetic NMR study with root cultures of Swertia chirata. (2003) (21)
Biosynthesis of Vitamin B2: A Unique Way to Assemble a Xylene Ring (2011) (21)
Biosynthesis of benzofuran derivatives in root cultures of Tagetes patula via phenylalanine and 1-deoxy-D-xylulose 5-phosphate. (2005) (21)
Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase. (2002) (21)
Biosynthetic origin of oxygen atoms in DIMBOA from maize: NMR studies with 18O2. (1997) (21)
A two-dimensional 1H NMR study on Megasphaera elsdenii flavodoxin in the reduced state. Sequential assignments. (1990) (21)
Biosynthesis of Vitamin B2 (2005) (21)
Biosynthesis of riboflavin. Single turnover kinetic analysis of 6,7-dimethyl-8-ribityllumazine synthase. (2003) (21)
Rearrangement reactions in the biosynthesis of molybdopterin--an NMR study with multiply 13C/15N labelled precursors. (1998) (21)
Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments (2003) (20)
Tryptophan 13C nuclear-spin polarization generated by intraprotein electron transfer in a LOV2 domain of the blue-light receptor phototropin. (2009) (20)
Tracer Studies with Crude U-13C-Lipid Mixtures (1997) (20)
Biosynthesis of riboflavin. 6,7-Dimethyl-8-ribityllumazine 5'-phosphate is not a substrate for riboflavin synthase. (1978) (20)
Heavy riboflavin synthase of Bacillus subtilis. Primary structure of the beta subunit. (1987) (20)
NMR studies on the 46-kDa dimeric protein, 3,4-dihydroxy-2-butanone 4-phosphate synthase, using 2H, 13C, and 15N-labelling. (1999) (20)
Biosynthesis of Methanopterin in Methanobacterium thermoautotrophicum (1986) (20)
Resonance Raman spectroscopic study of the neutral flavin radical complex of DNA photolyase fromEscherichia coli (2001) (20)
Ultrafast Structural Dynamics of BlsA, a Photoreceptor from the Pathogenic Bacterium Acinetobacter baumannii (2013) (20)
Dense liquid droplets as a step source for the crystallization of lumazine synthase (2005) (20)
Design, synthesis, and evaluation of acyclic C-nucleoside and N-methylated derivatives of the ribitylaminopyrimidine substrate of lumazine synthase as potential enzyme inhibitors and mechanistic probes. (2004) (20)
Unambiguous determination of the g-matrix orientation in a neutral flavin radical by pulsed electron-nuclear double resonance at 94 GHz. (2005) (20)
A novel lumazine synthase inhibitor derived from oxidation of 1,3,6,8-tetrahydroxy-2,7-naphthyridine to a tetraazaperylenehexaone derivative. (2007) (20)
Discovery and development of a small molecule library with lumazine synthase inhibitory activity. (2009) (20)
Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class. (2004) (20)
Stereochemical course of the reduction step in the formation of 2-C-methylerythritol from the terpene precursor 1-deoxyxylulose in higher plants (1999) (19)
Investigation of xanthine oxidase. Magnetic circular dichroism studies. (1971) (19)
Structure of lumazine protein, an optical transponder of luminescent bacteria. (2008) (19)
Biosynthesis of riboflavin in Archaea (2003) (19)
Design and synthesis of 6-(6-D-ribitylamino-2,4-dihydroxypyrimidin-5-yl)-1-hexyl phosphonic acid, a potent inhibitor of lumazine synthase. (1999) (19)
Prodrugs of reverse fosmidomycin analogues. (2015) (19)
Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis (2010) (19)
Biosynthesis of the chromogen hermidin from Mercurialis annua L. (2007) (18)
Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase. (2007) (18)
Molecular cloning of a cDNA coding for GTP cyclohydrolase I from Dictyostelium discoideum. (1996) (18)
Crystal structure of 7,8-dihydroneopterin triphosphate epimerase. (1999) (18)
Biosynthetic origin of a branched chain analogue of the lipase inhibitor, lipstatin. (2003) (18)
Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase. (2010) (18)
Solution structure of the antitermination protein NusB of Escherichia coli: a novel all‐helical fold for an RNA‐binding protein (1998) (18)
Vibrational assignment of the ultrafast infrared spectrum of the photoactivatable flavoprotein AppA. (2012) (18)
Detecting a new source for photochemically induced dynamic nuclear polarization in the LOV2 domain of phototropin by magnetic-field dependent (13)C NMR spectroscopy. (2014) (18)
Variation in LOV Photoreceptor Activation Dynamics Probed by Time-Resolved Infrared Spectroscopy. (2018) (18)
Biosynthesis of lipstatin. Incorporation of multiply deuterium-labeled (5Z,8Z)-tetradeca-5,8-dienoic acid and octanoic acid. (2001) (18)
Elucidation of crystal packing by X-ray diffraction and freeze-etching electron microscopy. Studies on GTP cyclohydrolase I of Escherichia coli. (1995) (18)
Ring Opening Is Not Rate-limiting in the GTP Cyclohydrolase I Reaction* (2001) (17)
Biosynthesis of 7,8-Didemethyl-8-hydroxy-5-deazariboflavin, the Chromophoric Moiety of Coenzyme F420 (1985) (17)
Fluorescence study of the ligand stereospecificity for binding to lumazine protein. (1992) (17)
Isotopologue profiling of triterpene formation under physiological conditions. Biosynthesis of lupeol-3-(3'-R-hydroxy)-stearate in Pentalinon andrieuxii. (2014) (17)
Biosynthesis of Tetrahydrofolate (2002) (17)
Biosynthesis of zeaxanthin via mevalonate in Paracoccus species strain PTA-3335. A product-based retrobiosynthetic study. (2002) (17)
Long-Lived Hydrated FMN Radicals: EPR Characterization and Implications for Catalytic Variability in Flavoproteins. (2018) (17)
Structures and reaction mechanisms of GTP cyclohydrolases (2013) (17)
Biosynthesis of Riboflavin. Incorporation of Multiply13C-Labeled Precursors into the Xylene Ring. (1986) (16)
Catalysis of an Essential Step in Vitamin B2 Biosynthesis by a Consortium of Broad Spectrum Hydrolases (2015) (16)
Separation of induction and expression of tight junction formation mediated by proteinases. (1984) (16)
Studies on the Non‐Mevalonate Pathway − Preparation and Properties of Isotope‐Labeled 2C‐Methyl‐D‐erythritol 2,4‐Cyclodiphosphate (2001) (16)
(Trifluoromethyl)lumazine derivatives as 19F NMR probes for lumazine protein. (1994) (16)
Lumazine proteins from photobacteria: localization of the single ligand binding site to the N-terminal domain (2007) (16)
Biosynthetic precursors of the lipase inhibitor lipstatin. (2002) (16)
Fluorine-19 NMR studies of the mechanism of riboflavin synthase. Synthesis of 6-(trifluoromethyl)-8-(D-ribityl)lumazine and derivatives (1993) (16)
Evidence for local 32 symmetry in homotrimeric riboflavin synthase of Escherichia coli. (1998) (16)
Biosynthesis of Riboflavin (2001) (15)
Biosynthesis of Riboflavin. Stereochemistry of the 3,4-Dihydroxy-2-butanone 4-Phosphate Synthase Reaction (1998) (15)
13C-, 15N- and 31P-NMR studies of oxidized and reduced low molecular mass thioredoxin reductase and some mutant proteins. (2004) (15)
Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5Å resolution. (2012) (15)
Electron microscopy of decorated crystals for the determination of crystallographic rotation and translation parameters in large protein complexes. (1992) (15)
Temperature-dependent Presteady State Kinetics of Lumazine Synthase from the Hyperthermophilic Eubacterium Aquifex aeolicus* (2003) (15)
Aryl Bis‐Sulfonamide Inhibitors of IspF from Arabidopsis thaliana and Plasmodium falciparum (2015) (15)
Biosynthesis of riboflavin. Enzymatic formation of the xylene moiety from [14C]ribulose 5-phosphate. (1984) (14)
Tracer studies with 13C-labeled carbohydrates in cultured plant cells. Retrobiosynthetic analysis of chelidonic acid biosynthesis. (2001) (14)
13C, 15N, and 31P NMR studies on 6-hydroxy-L-nicotine oxidase from Arthrobacter oxidans. (1989) (14)
Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate. (2004) (14)
Biosynthesis of Isoprenoids. A Rapid Method for the Preparation of Isotope-Labeled 4-Diphosphocytidyl-2C-methyl-d-erythritol (2000) (14)
One protein, two chromophores: comparative spectroscopic characterization of 6,7-dimethyl-8-ribityllumazine and riboflavin bound to lumazine protein. (2014) (14)
31P-NMR spectroscopy of human and Paracoccus denitrificans electron transfer flavoproteins, and 13C- and 15N-NMR spectroscopy of human electron transfer flavoprotein in the oxidised and reduced states. (1998) (14)
13C Isotopologue editing of FMN bound to phototropin domains (2007) (14)
Atovaquone for Prophylaxis of Toxoplasmosis after Allogeneic Hematopoietic Stem Cell Transplantation (2015) (13)
Pre-steady-state kinetic analysis of riboflavin synthase using a pentacyclic reaction intermediate as substrate (2005) (13)
Biosynthesis of vitamin B 2 in plants (2006) (13)
Nuclear magnetic resonance studies of the old yellow enzyme. 2. 13C NMR of the enzyme recombined with 13C-labeled flavin mononucleotides. (1985) (13)
Rapid preparation of isotopolog libraries by in vivo transformation of 1)C-glucose. Studies on 6,7-dimethyl-8-ribityllumazine, a biosynthetic precursor of vitamin B2. (2004) (13)
Electron microscopy of subnanometer surface features on metal-decorated protein crystals. (1989) (13)
Evolution of Vitamin B 2 Biosynthesis STRUCTURAL AND FUNCTIONAL SIMILARITY BETWEEN PYRIMIDINE DEAMINASES OF EUBACTERIAL AND PLANT ORIGIN* (2004) (13)
Complementation of the fol2 deletion in Saccharomyces cerevisiae by human and Escherichia coli genes encoding GTP cyclohydrolase I. (1999) (13)
Biosynthetic Origin of Hydrogen Atoms in the Lipase Inhibitor Lipstatin* (2000) (13)
Biosynthesis of riboflavin. Analysis of biosynthetically carbon-13-labeled riboflavin by double-quantum and two-dimensional NMR (1983) (12)
13C and 15N NMR studies on the interaction between 6,7-dimethyl-8-ribityllumazine and lumazine protein. (1990) (12)
Biosynthesis of riboflavin. An unusual rearrangement in the formation of 6,7-dimethyl-8-ribityllumazine (1983) (12)
Atomic-Resolution Structures of Discrete Stages on the Reaction Coordinate of the [Fe4S4] Enzyme IspG (GcpE). (2015) (12)
Biosynthesis of riboflavin : 13C-NMR techniques for the analysis of multiply 13C-labeled riboflavins (1983) (12)
Rapid formation of tight junctions in HT 29 human adenocarcinoma cells by hypertonic salt solutions. (1988) (12)
Effect of temperature on the assembly of tight junctions and on the mobility of lipids in membranes of HT29 cells. (1990) (12)
A tomato enzyme catalyzing the phosphorylation of 3,4-dihydroxy-2-butanone. (2002) (12)
Synthesis of bis(trifluoromethylated) pyrazine-containing nitrogen heterocycles from hexafluorobiacetyl and ortho-diamines. Stabilization of the covalent dihydrates of pteridines and pyrido[3,4-b]pyrazines by trifluoromethyl groups (1986) (12)
Biosynthesis of tetrahydrobiopterin: a sensitive assay of 6-pyruvoyltetrahydropterin synthase using [2'-3H]dihydroneopterin 3'-triphosphate as substrate. (1989) (12)
Stimulation of Vgamma9/Vdelta2 T-lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate. (2007) (11)
19F NMR ligand perturbation studies on 6,7-bis(trifluoromethyl)-8-ribityllumazine-7-hydrates and the lumazine synthase complex of Bacillus subtilis. Site-directed mutagenesis changes the mechanism and the stereoselectivity of the catalyzed haloform-type reaction. (2001) (11)
Isolation and structural identification of a chromophoric coenzyme F420 fragment from culture fluid of Methanobacterium thermoautotrophicum (1983) (11)
Multiple Oxygenase Reactions in the Biosynthesis of Taxoids (1998) (11)
Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP. (2001) (11)
Dihydroneopterin triphosphate epimerase of Escherichia coli: purification, genetic cloning, and expression (1997) (11)
Biosynthesis of Vitamin B2 and Flavocoenzymes in Plants (2011) (10)
Methyl groups matter: Photo-CIDNP characterizations of the semiquinone radicals of FMN and demethylated FMN analogs. (2019) (10)
Decoding Biosynthetic Pathways in Plants by Pulse-Chase Strategies Using 13CO2 as a Universal Tracer † (2016) (10)
Investigation of the binding of epimer A of the covalent hydrate of 6,7-bis(trifluoromethyl)-8-D-ribityllumazine to a recombinant F22W Bacillus subtilis lumazine synthase mutant by (15)N[(19)F] REDOR NMR. (2002) (10)
Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands. (2017) (10)
Sexual Dimorphism in the Response of Mercurialis annua to Stress (2016) (10)
Biosynthesis of biopterin. Studies on the mechanism of 6-pyruvoyltetrahydropteridine synthase. (1988) (10)
Structure and reaction mechanism of pyrrolysine synthase (PylD). (2013) (10)
Analysis of Gallic Acid Biosynthesis via Quantitative Prediction of Isotope Labeling Patterns (1999) (10)
Biosynthesis of Riboflavin. Enzymatic Deamination of 2,5-Diamino-6-hydroxy-4-ribitylaminopyrimidine-5′-phosphate (1980) (9)
Inhibition of methyl-CoM Reductase from Methanobrevibacter ruminantium by 2-bromoethanesulfonate. (2014) (9)
Hydrolysis and rearrangement reactions of riboflavin phosphates. An explicit kinetic study. (1985) (9)
Effect of protein synthesis inhibitors on formation and degradation of tight junctions in HT 29 adenocarcinoma cells. (1989) (9)
(15)N{(31)P} REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase. (2008) (9)
Biosynthetic experiments with tall plants under field conditions. 18O2 incorporation into humulone from Humulus lupulus. (2004) (9)
ELIMINATION OF THE 7-TRIFLUOROMETHYL GROUP FROM 6,7-BIS(TRIFLUOROMETHYL)-8-RIBITYLLUMAZINES. STEREOSELECTIVE CATALYSIS BY THE LUMAZINE SYNTHASE OF BAC ILLUS SUBTILIS (1995) (9)
Structure of the molybdenum-cofactor biosynthesis protein MoaB of Escherichia coli. (2004) (9)
Biosynthesis of Riboflavin SINGLE TURNOVER KINETIC ANALYSIS OF GTP CYCLOHYDROLASE II* (2001) (9)
DESIGN AND SYNTHESIS OF (RIBITYLAMINO)URACILS BEARING FLUOROSULFONYL, SULFONIC ACID, AND CARBOXYLIC ACID FUNCTIONALITY AS INHIBITORS OF LUMAZINE SYNTH ASE (1997) (9)
Biosynthesis of Riboflavin STUDIES ON THE MECHANISM OF GTP CYCLOHYDROLASE II* (2001) (9)
Crystal structures of the antitermination factor NusB from Thermotoga maritima and implications for RNA binding. (2004) (9)
Biosynthesis of riboflavin in archaea. 6,7-dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii. (2003) (8)
Evolution of Vitamin B 2 Biosynthesis (2004) (8)
O-Nucleoside, S-nucleoside, and N-nucleoside probes of lumazine synthase and riboflavin synthase. (2012) (8)
Unexpected Biosynthetic Precursors of Amarogentin — A Retrobiosynthetic 13C NMR Study. (2002) (8)
Conformation of 6,7-dimethyl-8-ribityllumazine bound to β-subunits of heavy riboflavin synthase: Transferred nuclear overhauser effect (TrNOE) studies employing ω1-13C-filtered NOESY including a novel technique for zero quantum suppression (1992) (8)
Towards an identification of chemically different flavin radicals by means of theirg-tensor (2006) (8)
Biosynthesis of Riboflavin. A Simple Synthesis of the Substrate and Product of the Pyrimidine Deaminase and of Structural Analogs (1988) (8)
Vibrational spectra of the ground and the singlet excited ππ* state of 6,7-dimethyl-8-ribityllumazine. (2011) (8)
Cyclohexa-1,5-diene-1-carbonyl-CoA hydratase [corrected], an enzyme involved in anaerobic metabolism of benzoyl-CoA in the denitrifying bacterium Thauera aromatica. (1998) (7)
Biosynthesis of riboflavin. Incorporation of D-[1-13C]ribose (1982) (7)
Crystallization and preliminary crystallographic characterization of GTP cyclohydrolase I from Escherichia coli. (1992) (7)
Structure and Properties of an Engineered Transketolase from Maize 1 Structure of Transketolase from Maize (2003) (7)
Excited State Vibrations of Isotopically Labeled FMN Free and Bound to a Light-Oxygen-Voltage (LOV) Protein. (2020) (7)
Structure and mechanism of GTP cyclohydrolase I of Escherichia coli. (1996) (7)
Synthesis of 6,7-bis(trifluoromethyl)-8-substituted pteridine-2,4(1H,3H)-dione (lumazine) hydrates from 4,5-diaminouracil hydrochlorides and perfluorobutane-2,3-dione. Stabilization of the transmolecular covalent hydrates of 8-substituted pteridinediones by trifluoromethyl groups (1986) (7)
Kristallstruktur der Methylornithin‐Synthase (PylB): Einblicke in die Biosynthese von Pyrrolysin (2012) (7)
Ligand-binding studies on heavy riboflavin synthase of Bacillus subtilis. (2005) (7)
Detection of a novel sepiapterin reductase mRNA: assay of mRNA in various cells and tissues of various species. (1993) (7)
SYNTHASE/RIBOFLAVIN SYNTHASE COMPLEX OF BACILLUS SUBTILIS (1996) (6)
Quantitative evaluation of heavy metal decoration on protein molecules - contrast, specificity and resolution (1995) (6)
Imidazole- and Benzimidazole-Based Inhibitors of the Kinase IspE: Targeting the Substrate-Binding Site and the Triphosphate-Binding Loop of the ATP Site (2013) (6)
Formation of metal nanoclusters on specific surface sites of protein molecules. (2002) (6)
Exploring the Ribose Sub-Pocket of the Substrate-Binding Site in Escherichia coli IspE: Structure-Based Design, Synthesis, and Biological Evaluation of Cytosines and Cytosine Analogues (2012) (6)
Studies on the NusB protein of Escherichia coli--expression and determination of secondary-structure elements by multinuclear NMR spectroscopy. (1997) (6)
Inhibition of the Non-Mevalonate Isoprenoid Pathway by Reverse Hydroxamate Analogues of Fosmidomycin☆ (2015) (6)
Location of the gene coding for GTP cyclohydrolase I on the physical map of Escherichia coli (1993) (6)
Tight junctions of jejunal surface and crypt cells in celiac disease: a freeze-fracture study. (1987) (6)
2,5‐diamino‐6‐ribitylamino‐4(3H)‐pyrimidinone 5′‐phosphate synthases of fungi and archaea (2008) (6)
Biosynthesis of Riboflavin Preparation of Phosphorylated Pyrimidine Intermediates (1984) (6)
Proteinase-induced formation of focal tight junctions in HT 29 adenocarcinoma cells does not require extracellular calcium. (1987) (6)
(−)‐2C‐Methyl‐d‐erythrono‐1,4‐lactone is formed after application of the terpenoid precursor 1‐deoxy‐d‐xylulose (1998) (6)
Random isotopolog libraries for protein perturbation studies. 13C NMR studies on lumazine protein of Photobacterium leiognathi. (2005) (5)
Phenylacetate catabolism in Escherichia coli (2003) (5)
Biosynthesis of Riboflavin. (2010) (5)
Aryl bis-sulfonamides bind to the active site of a homotrimeric isoprenoid biosynthesis enzyme IspF and extract the essential divalent metal cation cofactor† †Electronic supplementary information (ESI) available: Experimental procedures for the protein expression and purification, protein denaturati (2018) (5)
Ligand binding properties of the N-terminal domain of riboflavin synthase from Escherichia coli. (2007) (5)
Biosynthesis of coenzyme F420 and methanopterin in Methanobacterium thermoautotrophicum (1990) (5)
Preparation of flavocoenzyme isotopologues by biotransformation of purines. (2015) (5)
Influence of metabolic inhibitors on the degradation of tight junctions in HT29 cells. (1992) (5)
Strategy for Enhancement of (13)C-Photo-CIDNP NMR Spectra by Exploiting Fractional (13)C-Labeling of Tryptophan. (2015) (5)
5‐Substituted (1‐Thiolan‐2‐yl)cytosines as Inhibitors of A. aeolicus and E. coli IspE Kinases: Very Different Affinities to Similar Substrate‐Binding Sites (2013) (5)
Investigation of the Binding of Fluorolumazines to the 1-MDa Capsid of Lumazine Synthase by 15N{19F} REDOR NMR. (1999) (5)
Crystal structure of 3,4-Dihydroxy-2-butanone 4-phosphate Synthase of Candida albicans (2004) (5)
Localization of Two Enzymes of the Tetrahydrobiopterin Biosynthetic Pathway in Embryonic Chick Retina (2002) (4)
The N-terminal domain of riboflavin synthase in complex with riboflavin (2004) (4)
Crystallization and preliminary crystallographic analysis of the recombinant N-terminal domain of riboflavin synthase. (2001) (4)
Chapter 8:Blue Light-Initiated DNA Repair by Photolyase (2006) (4)
Problems in electron state assignment base on circular dichroism. Optical activity of diazines (1974) (4)
Studies of the intermediary metabolism in cultured cells of the insect Spodoptera frugiperda using 13C- or 15N-labelled tracers (2005) (4)
Reductive Dehydroxylation of Allyl Alcohols by IspH Protein (2011) (4)
RNA DNA discrimination by the antitermination protein NusB. (2003) (4)
Metamorphosis of an Enzyme (2009) (4)
Biosynthesis of methanofuran in Methanobacterium thermoautotrophicum. (1992) (4)
Biosynthesis of riboflavin. Bifunctional pyrimidine deaminase/reductase of Escherichia coli and Bacillus subtilis. (1996) (4)
Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity. (2019) (4)
Preparation of Isotope-labeled Dihydroneopterin 3'-Triphosphate with High Specific Activity (1990) (3)
Biosynthesis of hermidin from Mercurialis annua: A retrobiosynthetic study (2010) (3)
Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target (2019) (3)
Biosynthesis of flavins and deazaflavins (1987) (3)
Solution Structures of 6,7-Dimethyl-8-substituted-lumazines. 13C NMR Evidence for Intramolecular Ether Formation. (1987) (3)
CRYSTAL STRUCTURE ANALYSIS OF LUMAZINE SYNTHASE FROM AQUIFEX AEOLICUS (2001) (3)
8‐Substituted, syn‐Configured Adenosine Derivatives as Potential Inhibitors of the Enzyme IspE from the Non‐Mevalonate Pathway of Isoprenoid Biosynthesis (2015) (3)
BIOSYNTHESIS OF RIBOFLAVIN. INCORPORATION OF D‐(1‐13C)RIBOSE (1982) (3)
Biosynthesis of Riboflavin. Analysis of Biosynthetically13C-Labeled Riboflavin by Double-Quantum and Two-Dimensional NMR. (1983) (3)
Advances of High-Resolution NMR Techniques in the Structural and Metabolic Analysis of Plant Biochemistry (2008) (3)
Design and Synthesis of 6‐(6‐D‐Ribitylamino‐2,4‐dihydroxypyrimidin‐5‐yl)‐1‐hexylphosphonic Acid, a Potent Inhibitor of Lumazine Synthase. (1999) (3)
Blue light-induced DNA repair by photolyase (2006) (3)
Structural Basis of Fosmidomycin Action revealed by the Complex with IspC: Implications for the Catalytic Mechanism and Anti-Malaria Drug Development (2003) (3)
Improvement of the quality of lumazine synthase crystals by protein engineering. (2008) (3)
Influence of the cofactor structure on the photophysical processes initiating signal transduction in a phototropin-derived LOV domain. (2019) (3)
Biosynthesis of methanofuran (1988) (2)
The formation of pyrroline and tetrahydropyridine rings in amino acids catalyzed by pyrrolysine synthase (PylD). (2014) (2)
Nutritional Requirement for 4-Aminobenzoate Caused by Mutation of Dihydropteroate Synthetase (1976) (2)
Coupled Methyl Group Rotation in FMN Radicals Revealed by Selective Deuterium Labeling. (2020) (2)
The complex isotopologue space of glucose as a framework for the study of human intermediary metabolism (2015) (2)
Metabolic Studies Using the Retrobiosynthesis Concept – Theory, Technology, and Examples (2010) (2)
Solution Structure of 3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase of Riboflavin Biosynthesis (2001) (2)
Synthesis and Biological Evaluation of 7α,7α,7α,8α,8α,8α- Hexafluororiboflavin and 7α,7α,7α,8α,8α,8α-Hexafluoro-FMN (1983) (2)
Structural investigation on recombinant riboflavin synthase from E. coli. (1996) (2)
Auxin Biosynthesis in Maize Kernels 1 (2000) (2)
Biosynthesis ofRiboflavin: Cloning, Sequencing, and Expression oftheGeneCoding for3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase ofEscherichia coli (1992) (2)
Northern blot analysis of sepiapterin reductase mRNA in mammalian cell lines and tissues. (1993) (2)
Design, Synthesis, and Biochemical Evaluation of 1,5,6,7‐Tetrahydro‐6,7‐dioxo‐9‐D‐Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine Synthase and Riboflavin Synthase. (2005) (1)
Chapter 2 Recent Advances in Ribofl avin Biosynthesis (2019) (1)
C-13, N-15 and two dimensional NMR techniques in flavoproteins research. (1987) (1)
Recent Advances in Ribofl avin Biosynthesis (2019) (1)
Non-classical disproportionation revealed by photo-CIDNP NMR (2021) (1)
Selective 13C labelling reveals the electronic structure of flavocoenzyme radicals (2021) (1)
MEDI 404-Non-phosphate inhibitors of IspE, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy (2007) (1)
Electron microscopy and X-ray diffraction studies on heavy riboflavin synthase from Bacillus subtilis (1984) (1)
Enzymatic Synthesis of 6,7-Dimethyl-8-Ribityllumazine (1986) (1)
LUMAZINE SYNTHASE FROM SACCHAROMYCES CEREVISIAE (2001) (1)
Detection of an FMN Radical in a C 450 A Mutant of Phototropin 10975 (2003) (1)
The Icosahedral 180 Subunit Capsid of the Aquifex aeolicus Luzmazine Synthase IDEA Mutant Does Not Follow the Quasi-equivalence (2006) (1)
3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii (2004) (1)
Inhibitors of the Bifunctional 2‐C‐Methyl‐d‐erythritol 4‐Phosphate Cytidylyl Transferase/2‐C‐Methyl‐d‐erythritol‐2,4‐cyclopyrophosphate Synthase (IspDF) ofHelicobacter pylori (2019) (1)
Completing the Picture: Determination of 13C Hyperfine Coupling Constants of Flavin Semiquinone Radicals by Photochemically Induced Dynamic Nuclear Polarization Spectroscopy. (2022) (1)
Cover Picture: Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis (Angew. Chem. Int. Ed. 6/2012) (2012) (1)
7,8-DIHYDRONEOPTERIN TRIPHOSPHATE EPIMERASE (2000) (1)
Tryptophan 13 C nuclear-spin polarization generated by intraprotein electron transfer in a LOV 2 domain of the bluelight receptor phototropin (2009) (1)
Studies on the Reaction Mechanism of GTP Cyclohydrolase I (2002) (1)
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) (2002) (1)
Biosynthesis of Riboflavin Synthesis of the Substrate and of Substrate Analogiies for Pyrimidine Deaminase (1983) (1)
3,4-dihydroxy-2-butanone 4-phosphate synthase from M. jannaschii in complex with ribulose 5-phosphate (2003) (1)
2C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) from Arabidopsis thaliana (2006) (1)
DIASTEREOMERIC REACTION INTERMEDIATES OF ARCHAEAL AND NON-ARCHAEAL RIBOFLAVIN SYNTHASES*□ S (2005) (1)
Non-classical disproportionation revealed by photo-chemically induced dynamic nuclear polarization NMR (2021) (1)
Binding of pteridine derivatives to lumazine apoprotein (1990) (1)
A comparative time-resolved electron paramagnetic resonance study of the flavin cofactor photoreduction in Escherichia coli cyclobutane pyrimidine dimer photolyase and Xenopus laevis (6–4) photolyase (2002) (1)
Crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine (2004) (0)
Ec_IspH in complex with 4-hydroxybutyl diphosphate (1301) (2012) (0)
Stereochemical Studies on the Making and Unmaking of Isopentenyl Diphosphate in Different Biological Systems (2004) (0)
A Real-space Electron Crystallographic Method for Elucidation of Crystal Packing of a Large, Symmetric Protein Complex (1992) (0)
CRYSTALLOGRAPHY OF BIOLOGICAL MACROMOLECULES C188 (2005) (0)
CRYSTAL STRUCTURE OF HUMAN GTP CYCLOHYDROLASE I (2000) (0)
PylD cocrystallized with L-Lysine-Ne-D-lysine and NAD+ (2014) (0)
ANTITERMINATION FACTOR NUSB FROM ESCHERICHIA COLI, NMR, 18 STRUCTURES (1998) (0)
Crystal Structure of an archaeal pentameric riboflavin synthase (2005) (0)
Structure of 6,7-Dimethyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound riboflavin (2005) (0)
Protein conjugates on the basis of lumazine synthase, methods for producing them and the use thereof (2000) (0)
Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 5-(6-D-ribitylamino-2,4(1H,3H)pyrimidinedione-5-yl)-1-pentyl-phosphonic acid (2004) (0)
Heavy riboflavin synthase from Bacillus subtilis. Primary structure and reaggregation of the B subunits (1984) (0)
IspG in complex MEcPP (2015) (0)
Assembly of tight junctions in cultured human epithelial cells. (1986) (0)
Epithelial cell culture on carbon-coated semipermeable supports (1992) (0)
[Intermediary products of riboflavin biosynthesis]. (1972) (0)
Mutant enzyme W63Y/L119F Lumazine Synthase from S.pombe (2002) (0)
PylD in complex with pyrroline-carboxy-lysine and NADH (2013) (0)
PylD in complex with L-lysine-Ne-D-ornithine and NADH (2013) (0)
CRYSTAL STRUCTURE OF ZINC-CONTAINING E.COLI GTP CYCLOHYDROLASE I (2001) (0)
Crystal structure of MoaB from Escherichia coli (2004) (0)
SEPIAPTERIN REDUCTASE COMPLEXED WITH N-ACETYL SEROTONIN (1999) (0)
Assay for inhibitors IspH (2004) (0)
Process for producing lipestatina and tetrahidrolipestatina. (1997) (0)
IspH in complex with 6-chloropyridin-3-ylmethyl diphosphate (2014) (0)
A comparative NMR study on the interaction of FMN with apoflavodoxins (1985) (0)
IspH:HMBPP complex structure of E126Q mutant (2011) (0)
NMR-based isotopologue profiling of microbial carotenoids. (2012) (0)
Titelbild: Kristallstruktur der Methylornithin‐Synthase (PylB): Einblicke in die Biosynthese von Pyrrolysin (Angew. Chem. 6/2012) (2012) (0)
Effect of temperature on the assembly rate of TJ and on membrane fluidity in HT29 cells (1988) (0)
Arabidopsis thaliana IspD apo (2014) (0)
Ec_IspH in complex with 4-oxobutyl diphosphate (1302) (2012) (0)
PylD cocrystallized with L-Ornithine-Nd-D-ornithine and NAD+ (2014) (0)
GTP cyclohydrolase I from Escherichia coli. Molecular cloning and crystallization (1990) (0)
IspC apo structure (2003) (0)
Studies on riboflavin synthases of Bacillus subtilis. Amino acid sequence of the a subunit (1990) (0)
IspH in complex with pyridin-2-ylmethyl diphosphate (2014) (0)
Inhibitors of the kinase (2008) (0)
SeMet-labeled PylC (remote) (2012) (0)
Synthesis of 6,7-Bis(trifluoromethyl)-8-substituted Pteridine-2,4(1H,3H)-dione (Lumazine) Hydrates from 4,5-Diaminouracil Hydrochlorides and Perfluorobutane- 2,3-dione. Stabilization of the Transmolecular Covalent Hydrates of 8-Substi (1986) (0)
CCDC 632407: Experimental Crystal Structure Determination (2008) (0)
Crystal structure of IspH:Intermediate-complex (2010) (0)
Crystal Structure of Lumazine Synthase from Bacillus Anthracis (2010) (0)
Excited State Vibrations of Isotopically Labelled FMN Free and Bound to a LOV Protein (2020) (0)
IspH in complex with (E)-4-mercapto-3-methylbut-2-enyl diphosphate (2013) (0)
X-RAY Structure of 2,5-diamino-6-ribosylamino-4(3h)-pyrimidinone 5-phosphate reductase (2006) (0)
Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 6,7-dioxo-5H-8-ribitylaminolumazine (2004) (0)
IspG in complex with Inhibitor 8 (compound 1077) (2015) (0)
IspC Mn2+ complex (2003) (0)
PylD cocrystallized with L-Ornithine-Nd-D-lysine and NAD+ (2014) (0)
Lumazine Synthase from Mycobacterium tuberculosus Bound to 3-(1,3,7- TRIHYDRO-9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL) (2006) (0)
Structure of Plasmodium IspC in complex with a beta-thia-isostere derivative of Fosmidomycin (2013) (0)
Biosynthesis ofRiboflavine inSaccharomyces cerevisiae: theRoleofGenesrib, andrib7 (1972) (0)
A method for soluble overexpression of the oil nicotinic acetylcholine receptor (2016) (0)
MOUSE SEPIAPTERIN REDUCTASE COMPLEXED WITH NADP AND OXALOACETATE (1999) (0)
Crystal structure of IspG (gcpE) (2010) (0)
Detection and quantification of GTP cyclohydrolase I mRNA. (1993) (0)
IspG in complex with Intermediate II (2015) (0)
PURIFICATION AND CHARACTERIZATION OF NOVEL ENZYMES IN TERPENOID BIOSYNTHESIS (2005) (0)
PylD cocrystallized with L-Lysine-Ne-3S-methyl-L-ornithine and NAD+ (2014) (0)
Arabidopsis thaliana IspD in complex with pentabromo-pseudilin (2014) (0)
Structure of the Riboflavin Synthase/Lumazine Synthase Complex. Arrangement and Chain Folding of Subunits in the Icosahedral Capsid (1986) (0)
IspC complex with Mn2+ and fosmidomycin (2003) (0)
Ec_IspH in complex with but-2-ynyl diphosphate (1086) (2012) (0)
High Resolution Electron Microscopy on Crystals of the Icosahedral Lumazine Synthase/Riboflavin Synthase Complex (1990) (0)
IspC in complex with an N-methyl-substituted hydroxamic acid (2011) (0)
3,4-dihydroxy-2-butanone 4-phosphate synthase from M. jannaschii (2003) (0)
Arabidopsis thaliana IspD in complex with Isoxazole (4) (2017) (0)
Cover Picture: Catalysis of an Essential Step in Vitamin B2 Biosynthesis by a Consortium of Broad Spectrum Hydrolases (ChemBioChem 17/2015) (2015) (0)
IspG in complex with HMBPP (2015) (0)
LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 4-(6- chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)butyl phosphate (2006) (0)
IspH:HMBPP (substrate) structure of the E126D mutant (2011) (0)
Solution structure of the antitermination protein NusB of Escherichia coli: a novel all‐helical fold for an RNA‐binding protein (2013) (0)
PylC in complex with phosphorylated D-ornithine (2012) (0)
A kinetic study on the acid-catalysed phosphate migration in riboflavin phosphates (1984) (0)
IspF with Mg and CDP (2004) (0)
PylC in complex with D-ornithine and AMPPNP (2012) (0)
IspF with 4-diphosphocytidyl-2c-methyl-D-erythritol 2-phosphate (2004) (0)
Structure of 6,7-Dimthyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound ligand 6-carboxyethyl-7-oxo-8-ribityllumazine (2005) (0)
Arabidopsis thaliana IspD Glu258Ala Mutant (2017) (0)
Arabidopsis thaliana IspD Glu258Ala mutant in complex with Azolopyrimidine (1) (2017) (0)
Hydroxylation by flavin enzymes : evidence for NIH-shift mechanism (1999) (0)
Structure of 6,7-Dimethyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound ligand 5-nitroso-6-ribitylamino-2,4(1H,3H)-pyrimidinedione (2005) (0)
IspH in complex with pyridin-3-ylmethyl diphosphate (2014) (0)
Crystal Structure of an archaeal pentameric riboflavin synthase Complex with a Substrate analog inhibitor (2005) (0)
IspH:Ligand Mutants - wt 70sec (2011) (0)
University of Groningen Inhibitors of the kinase (2018) (0)
SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF RIBOFLAVIN SYNTHASE FROM E. COLI (2001) (0)
Determining Structural Differences in the Dark and Light States of AppA using Vibrational and Ultrafast Fluorescence Spectroscopy (2010) (0)
Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 5-nitroso-6-ribityl-amino-2,4(1H,3H)pyrimidinedione (2004) (0)
Crystal structure of IspH:DMAPP-complex (2010) (0)
PylC in complex with L-lysine (2012) (0)
Arabidopsis thaliana IspD Glu258Ala mutant in complex with Azolopyrimidine (2) (2017) (0)
Applications of modern electro paramagnetic resonance spectroscopy to the study of flavoproteins. (2005) (0)
LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 3-(1,3,7- TRIHYDRO-9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL) 1,1 difluoropentane-1- PHOSPHATE (2006) (0)
IPP:DMAPP isomerase type II apo structure (2003) (0)
Detection and Quantification of GTP Cyclohydrolase I m RNA (1993) (0)
Direct EPR-observation of the photo-induced triplet state of flavin mononucleotide (2005) (0)
Pteridines in riboflavin biosynthesis (1990) (0)
Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 3-(7-hydroxy-8-ribityllumazine-6-yl)propionic acid (2004) (0)
IspG in complex with Inhibitor 7 (compound 1061) (2015) (0)
Crystal Structure of 3,4-Dihydroxy-2-butanone 4-phosphate Synthase of Candida albicans in complex with Ribulose-5-phosphate (2004) (0)
Maize Transketolase in complex with TPP (2003) (0)
Arabidopsis thaliana IspD in complex with tribromodichloro-pseudilin (2014) (0)
Desulfovibrio vulgaris flavodoxin. A 13C and 15N NMR investigation (1984) (0)
Ec_IspH in complex with (E)-4-hydroxybut-3-enyl diphosphate (2012) (0)
T. maritima NusB, P3121, Form 2 (2004) (0)
GTP CYCLOHYDROLASE I (C110S MUTANT) IN COMPLEX WITH GTP (1999) (0)
On the enzymatic mechanism of lumazine synthase (2002) (0)
PylD in complex with pyrrolysine and NADH (2014) (0)
MOUSE SEPIAPTERIN REDUCTASE COMPLEXED WITH NADP AND SEPIAPTERIN (1999) (0)
Ferritin from T. maritima (2006) (0)
Functional Studies on the Promoter Region of the Human GTP Cyclohydrolase I Gene (1995) (0)
Structure of active IspH shows a novel fold with a [3Fe-4S] cluster in the catalytic centre (2009) (0)
Lumazine Synthase from S.pombe bound to nitropyrimidinedione (2002) (0)
A roadmap to the isotopolog space of flavocoenzymes. (2014) (0)
Transfer of hydrogen atoms from pentose phosphate to the xylene ring of riboflavin (1984) (0)
3D Structure of Lumazine Synthase from Candida albicans (2007) (0)
Lumazine Synthase from S.pombe bound to carboxyethyllumazine (2002) (0)
IspH:HMBPP complex after 3 minutes X-ray pre-exposure (2011) (0)
3TA2-07 Magnetic Field Effects on the photochemical reactions in protein systems(The 47th Annual Meeting of the Biophysical Society of Japan) (2009) (0)
Lumazine Synthase from S.pombe bound to riboflavin (2002) (0)
BIOSYNTHESIS OF PTERIDINES AND DEAZA FLAVINS IN METHANOGENIC BACTERIA (1987) (0)
Lumazine synthase RibH1 from Brucella melitensis (Gene BMEI1187, Swiss-Prot entry Q8YGH2) complexed with inhibitor 5-Nitro-6-(D-Ribitylamino)-2,4(1H,3H) Pyrimidinedione (2007) (0)
PylD holoenzyme soaked with L-lysine-Ne-D-ornithine (2013) (0)
The involvement of proteins in the formation of tight junctions in the human colon adenocarcinoma cell line HT 29 (1987) (0)
IspF with 4-diphosphocytidyl-2C-methyl-D-erythritol (2004) (0)
Protein conjugates, methods, vectors, proteins and DNA for their preparation, their use, as well as drugs and vaccines containing the same (1999) (0)
Ec_IspH in complex with 4-oxopentyl diphosphate (2012) (0)
Crystal structure of an enzyme involved in the biosynthesis of isoprenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol kinase from E. coli, a potential drug target (2005) (0)
Structure of 2C-Methyl-D-Erythritol 2,4-Clycodiphosphate Synthase complexed with a CDP derived fluorescent inhibitor (2006) (0)
Biosynthesis of Flavocoenzymes (2005) (0)
The icosahedral ß60 capsid of heavy riboflavin synthase (6,7- dimethyl-8-ribityllumazine synthase/riboflavin synthase) (1987) (0)
IspG in complex with PPi (2015) (0)
PylC in complex with L-lysine-Ne-D-ornithine (cocrystallized with L-lysine and D-ornithine) (2012) (0)
Detection d'inhibiteurs de isph (2004) (0)
Supplementary material to "Non-classical disproportionation revealed by photo-CIDNP NMR" (2021) (0)
The g-tensor of neutral flavin radicals (2005) (0)
Lumazine synthase RibH1 from Brucella abortus (Gene BruAb1_0785, Swiss-Prot entry Q57DY1) complexed with inhibitor 5-Nitro-6-(D-Ribitylamino)-2,4(1H,3H) Pyrimidinedione (2006) (0)
Arabidopsis thaliana IspD Asp262Ala Mutant (2017) (0)
Breakthrough Technologies Retrobiosynthetic Nuclear Magnetic Resonance Analysis of Amino Acid Biosynthesis and Intermediary Metabolism . Metabolic Flux in Developing Maize Kernels 1 (2001) (0)
Lumazine synthase RibH1 from Brucella abortus (Gene BruAb1_0785, Swiss-Prot entry Q57DY1) (2007) (0)
T. maritima NusB, P212121 (2004) (0)
IspG in complex with Epoxide Intermediate (2015) (0)
Synthesis of Bis(trifluoromethylated)Pyrazine-containing Nitrogen Heterocycles from Hexafluorobiacetyl and ortho-Diamines. Stabilization of the Covalent Dihydrates of Pteridines and Pyrido[3,4-b]pyrazines by Trifluoromethyl Groups. (1986) (0)
IspH in complex with (E)-4-fluoro-3-methylbut-2-enyl diphosphate (2013) (0)
13C, 15N and 2D-NMR techniques in flavoprotein research. (1987) (0)
PylD holoenzyme (SeMet) (2013) (0)
T. maritima NusB, P3221 (2004) (0)
Assays for the search of inhibitors of IspH reaction (2003) (0)
Structure and Properties of an Engineered Transketolase from Maize 1 (2003) (0)
Biosynthesis of Riboflavin Origin of the Xylene Ring (1983) (0)
IspH in complex with pyridin-4-ylmethyl diphosphate (2014) (0)
Ec_IspH in complex with buta-2,3-dienyl diphosphate (1300) (2012) (0)
Multiple assembly states of lumazine synthase (2004) (0)
T. maritima NusB, P3121, Form 1 (2004) (0)
Structural basis for a NusA- protein N interaction (2004) (0)
IspH in complex with propynyl diphosphate (1061) (2012) (0)
Riboflavin Kinase and Fad Synthetase (2018) (0)
IPP:DMAPP isomerase type II, FMN complex (2003) (0)
LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO N-6-(ribitylamino)pyrimidine-2,4(1H,3H)-dione-5-yl-propionamide (2008) (0)
Crystal structure of IspH in complex with iso-HMBPP (2013) (0)
Lumazine synthase RibH2 from Mesorhizobium loti (Gene mll7281, Swiss-Prot entry Q986N2) complexed with inhibitor 5-Nitro-6-(D-Ribitylamino)-2,4(1H,3H) Pyrimidinedione (2007) (0)
Structure cristalline de 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase (2002) (0)
Biosynthesis of 6,7-dimethyl-8-ribityllumazine. Purification and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase (1990) (0)
Exploitation of Geometric Redundancies as a Source of Phase Information in X-Ray Structure Analysis of Symmetric Protein Assemblies — Including a worked example: the three-dimensional structure of the icosahedral β60 capsid of heavy riboflavin synthase from Bacillus subtilis (1989) (0)
Specific Decoration Sites on Frozen-hydrated Crystals of Heavy Riboflavin Synthase (1988) (0)
:thyl-D-erythritol i-D-erythritol (2016) (0)
Riboflavin Synthase from S.pombe bound to Carboxyethyllumazine (2002) (0)

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