Adrian Krainer
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Uruguayan neuroscientist
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Biology
Adrian Krainer 's Degrees
- PhD Molecular Biology University of Buenos Aires
- Bachelors Biochemistry University of Buenos Aires
Why Is Adrian Krainer Influential?
(Suggest an Edit or Addition)According to Wikipedia, Adrian Robert Krainer is a Uruguayan-American biochemist and molecular geneticist known for his research into RNA gene-splicing. He helped create a drug for patients with spinal muscular atrophy. Krainer holds the St. Giles Foundation Professorship at Cold Spring Harbor Laboratory in Laurel Hollow, New York.
Adrian Krainer 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Listening to silence and understanding nonsense: exonic mutations that affect splicing (2002) (2197)
- ESEfinder: a web resource to identify exonic splicing enhancers (2003) (1574)
- The human splicing code reveals new insights into the genetic determinants of disease (2015) (1040)
- RNA therapeutics: beyond RNA interference and antisense oligonucleotides (2012) (960)
- The gene encoding the splicing factor SF2/ASF is a proto-oncogene (2007) (869)
- CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function (2015) (775)
- Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1 (2002) (729)
- Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2 (1992) (694)
- Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. (1993) (671)
- Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. (1994) (655)
- Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro (1984) (579)
- Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. (1998) (541)
- Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model. (2010) (541)
- Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro (1984) (536)
- Pre-mRNA splicing in the new millennium. (2001) (523)
- An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancers. (2006) (499)
- A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. (1998) (498)
- A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes (2001) (491)
- Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators (1991) (476)
- Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice. (2008) (458)
- Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss (2016) (450)
- Role of the Modular Domains of SR Proteins in Subnuclear Localization and Alternative Splicing Specificity (1997) (448)
- Antisense Oligonucleotides Delivered to the Mouse CNS Ameliorate Symptoms of Severe Spinal Muscular Atrophy (2011) (444)
- The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites (1990) (430)
- Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins. (2001) (422)
- The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism (2010) (384)
- Peripheral SMN restoration is essential for long-term rescue of a severe SMA mouse model (2011) (383)
- Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. (1998) (382)
- The Mkk3/6-p38–Signaling Cascade Alters the Subcellular Distribution of Hnrnp A1 and Modulates Alternative Splicing Regulation (2000) (364)
- Comprehensive splice-site analysis using comparative genomics (2006) (356)
- THE SPLICING FACTOR SRSF1 REGULATES APOPTOSIS AND PROLIFERATION TO PROMOTE MAMMARY EPITHELIAL CELL TRANSFORMATION (2011) (350)
- Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. (1994) (345)
- SR proteins function in coupling RNAP II transcription to pre-mRNA splicing. (2007) (341)
- Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro (1985) (337)
- HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. (2014) (329)
- Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA. (1999) (315)
- Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells. (1990) (315)
- Correction of disease-associated exon skipping by synthetic exon-specific activators (2003) (315)
- Identification and characterization of three members of the human SR family of pre‐mRNA splicing factors. (1995) (309)
- General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. (1993) (303)
- Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon (2007) (296)
- Serine Phosphorylation of SR Proteins Is Required for Their Recruitment to Sites of Transcription In Vivo (1998) (291)
- Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. (2008) (290)
- Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2. (2006) (287)
- hnRNP A/B proteins are required for inhibition of HIV‐1 pre‐mRNA splicing (1999) (285)
- A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (2010) (283)
- Manipulation of Alternative Splicing by a Newly Developed Inhibitor of Clks* (2004) (273)
- Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF (1993) (263)
- A positive modifier of spinal muscular atrophy in the SMN2 gene. (2009) (251)
- Functional analysis of pre‐mRNA splicing factor SF2/ASF structural domains. (1993) (248)
- Exonic Splicing Enhancer Motif Recognized by Human SC35 under Splicing Conditions (2000) (244)
- SRSF1-Regulated Alternative Splicing in Breast Cancer. (2015) (241)
- Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing. (1994) (238)
- Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein. (1999) (237)
- General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. (1992) (237)
- Alternative Splicing in Colon, Bladder, and Prostate Cancer Identified by Exon Array Analysis*S (2008) (233)
- Selection of Alternative 5′ Splice Sites: Role of U1 snRNP and Models for the Antagonistic Effects of SF2/ASF and hnRNP A1 (2000) (228)
- Pharmacology of a Central Nervous System Delivered 2′-O-Methoxyethyl–Modified Survival of Motor Neuron Splicing Oligonucleotide in Mice and Nonhuman Primates (2014) (212)
- Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ASF. (1993) (206)
- Involvement of SR proteins in mRNA surveillance. (2004) (203)
- A splicing-independent function of SF2/ASF in microRNA processing. (2010) (201)
- Emerging Functions of SRSF1, Splicing Factor and Oncoprotein, in RNA Metabolism and Cancer (2014) (200)
- Pre-mRNA splicing in the absence of an SR protein RS domain. (2000) (196)
- SF2/ASF Autoregulation Involves Multiple Layers of Post-transcriptional and Translational Control (2010) (192)
- Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly (2011) (191)
- Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors (1994) (190)
- Pick one, but be quick: 5' splice sites and the problems of too many choices. (2013) (187)
- Splicing-factor alterations in cancers (2016) (184)
- Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. (1993) (177)
- Oncogenic splicing factor SRSF1 is a critical transcriptional target of MYC. (2012) (175)
- atSRp30, one of two SF2/ASF-like proteins from Arabidopsis thaliana, regulates splicing of specific plant genes. (1999) (175)
- Nuclear Export and Retention Signals in the RS Domain of SR Proteins (2002) (171)
- Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia. (2019) (168)
- Substrate Specificities of SR Proteins in Constitutive Splicing Are Determined by Their RNA Recognition Motifs and Composite Pre-mRNA Exonic Elements (1999) (164)
- Antisense Oligonucleotide Therapies for Neurodegenerative Diseases. (2019) (164)
- AT-AC Pre-mRNA Splicing Mechanisms and Conservation of Minor Introns in Voltage-Gated Ion Channel Genes (1999) (160)
- Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock. (2005) (158)
- Intrinsic differences between authentic and cryptic 5' splice sites. (2003) (153)
- Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes (2005) (153)
- Aberrant 5′ splice sites in human disease genes: mutation pattern, nucleotide structure and comparison of computational tools that predict their utilization (2007) (152)
- hnRNP A1 associates with telomere ends and stimulates telomerase activity. (2006) (152)
- Purification and characterization of human RNPS1: a general activator of pre‐mRNA splicing (1999) (144)
- Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations: a synonymous SNP in exon 5 of MCAD protects from deleterious mutations in a flanking exonic splicing enhancer. (2007) (141)
- The Subcellular Localization of SF2/ASF Is Regulated by Direct Interaction with SR Protein Kinases (SRPKs)* (1999) (141)
- Determinants of the inherent strength of human 5' splice sites. (2005) (128)
- Control of Pre-mRNA Splicing by the General Splicing Factors PUF60 and U2AF65 (2007) (128)
- Antisense-based therapy for the treatment of spinal muscular atrophy (2012) (126)
- RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins. (1997) (124)
- RNA Splicing at Human Immunodeficiency Virus Type 1 3′ Splice Site A2 Is Regulated by Binding of hnRNP A/B Proteins to an Exonic Splicing Silencer Element (2001) (123)
- Coordinated Alterations in RNA Splicing and Epigenetic Regulation Drive Leukemogenesis (2019) (121)
- Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers (2017) (120)
- The splicing-factor oncoprotein SF2/ASF activates mTORC1 (2008) (119)
- Extensive in silico analysis of NF1 splicing defects uncovers determinants for splicing outcome upon 5′ splice‐site disruption (2007) (118)
- Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing. (1999) (117)
- OLego: fast and sensitive mapping of spliced mRNA-Seq reads using small seeds (2013) (115)
- Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing. (1992) (113)
- Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs. (1997) (113)
- Motor neuron cell-nonautonomous rescue of spinal muscular atrophy phenotypes in mild and severe transgenic mouse models (2015) (113)
- Eukaryotic mRNA processing (1997) (112)
- Cooperative-Binding and Splicing-Repressive Properties of hnRNP A1 (2009) (111)
- The adenovirus E4‐ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins (2001) (108)
- NIPP1-mediated Interaction of Protein Phosphatase-1 with CDC5L, a Regulator of Pre-mRNA Splicing and Mitotic Entry* (2000) (106)
- Disruption of exonic splicing enhancer elements is the principal cause of exon skipping associated with seven nonsense or missense alleles of NF1 (2004) (104)
- RNA landscape of evolution for optimal exon and intron discrimination (2008) (104)
- Pre-mRNA splicing by complementation with purified human U1, U2, U4/U6 and U5 snRNPs. (1988) (102)
- BRCA2 T2722R is a deleterious allele that causes exon skipping. (2002) (102)
- Splicing factor SRSF6 promotes hyperplasia of sensitized skin (2014) (100)
- Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence. (2013) (98)
- Isolated pseudo–RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition (2013) (96)
- Arginine Methylation Controls the Subcellular Localization and Functions of the Oncoprotein Splicing Factor SF2/ASF (2010) (94)
- Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factors. (1996) (94)
- SpliceTrap: a method to quantify alternative splicing under single cellular conditions (2011) (93)
- Mammalian in vitro splicing assays. (1999) (93)
- SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage (2017) (92)
- S6K1 alternative splicing modulates its oncogenic activity and regulates mTORC1. (2013) (91)
- Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing. (2012) (90)
- U1-Mediated Exon Definition Interactions Between AT-AC and GT-AG Introns (1996) (90)
- The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor. (1999) (89)
- A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. (1997) (89)
- Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons. (2012) (88)
- The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA- and DNA-binding protein p54nrb/NonO (1997) (86)
- Features of 5'-splice-site efficiency derived from disease-causing mutations and comparative genomics. (2007) (85)
- Tetracyclines That Promote SMN2 Exon 7 Splicing as Therapeutics for Spinal Muscular Atrophy (2009) (84)
- Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides. (2012) (84)
- A novel histone exchange factor, protein phosphatase 2Cγ, mediates the exchange and dephosphorylation of H2A–H2B (2006) (81)
- Human Immunodeficiency Virus Type 1 hnRNP A/B-Dependent Exonic Splicing Silencer ESSV Antagonizes Binding of U2AF65 to Viral Polypyrimidine Tracts (2003) (80)
- Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2. (2012) (80)
- Recognition of atypical 5' splice sites by shifted base-pairing to U1 snRNA (2008) (80)
- RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns (2016) (80)
- Alternative Splicing of SLC39A14 in Colorectal Cancer is Regulated by the Wnt Pathway* (2010) (79)
- Decrease in hnRNP A/B expression during erythropoiesis mediates a pre‐mRNA splicing switch (2002) (77)
- DAZL Limits Pluripotency, Differentiation, and Apoptosis in Developing Primordial Germ Cells (2014) (75)
- Kaposi's Sarcoma-Associated Herpesvirus ORF57 Functions as a Viral Splicing Factor and Promotes Expression of Intron-Containing Viral Lytic Genes in Spliceosome-Mediated RNA Splicing (2008) (75)
- The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles (1994) (74)
- Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs. (1997) (74)
- An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites (2005) (73)
- Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing. (1999) (70)
- Mammalian pre-mRNA splicing factors (1997) (69)
- p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state (2014) (68)
- Antisense-oligonucleotide-directed inhibition of nonsense-mediated mRNA decay (2015) (68)
- Quantitative Activity Profile and Context Dependence of All Human 5' Splice Sites. (2018) (68)
- Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing. (1999) (66)
- Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. (2001) (64)
- Alternative Splicing of the Adenylyl Cyclase Stimulatory G-protein Gαs Is Regulated by SF2/ASF and Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNPA1) and Involves the Use of an Unusual TG 3′-Splice Site* (2002) (64)
- Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components (2007) (62)
- Alternative splicing regulation by interaction of phosphatase PP2Cγ with nucleic acid–binding protein YB-1 (2007) (62)
- A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. (1997) (59)
- A-44G transition in SMN2 intron 6 protects patients with spinal muscular atrophy (2017) (58)
- Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis. (2019) (56)
- Human p32: a coactivator for Epstein-Barr virus nuclear antigen-1-mediated transcriptional activation and possible role in viral latent cycle DNA replication. (2000) (56)
- Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides (2012) (53)
- Global identification of hnRNP A1 binding sites for SSO-based splicing modulation (2016) (52)
- Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB (2007) (51)
- Identification of Synaptic Targets of Drosophila Pumilio (2008) (51)
- Functional significance of a deep intronic mutation in the ATM gene and evidence for an alternative exon 28a (2005) (50)
- Distinct functions of the closely related tandem RNA-recognition motifs of hnRNP A1. (1998) (49)
- Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription. (1992) (49)
- Two Proteins Essential for Apolipoprotein B mRNA Editing Are Expressed from a Single Gene through Alternative Splicing* (2002) (48)
- Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP. (2009) (47)
- Nucleotide sequence at the end of the gene for the RNA polymerase beta' subunit (rpoC). (1981) (46)
- Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1 (2018) (46)
- SnapShot: Splicing Alterations in Cancer (2020) (43)
- Pathological impact of SMN2 mis-splicing in adult SMA mice (2013) (42)
- Differential connectivity of splicing activators and repressors to the human spliceosome (2015) (41)
- Dual-specificity splice sites function alternatively as 5′ and 3′ splice sites (2007) (39)
- Short/branched-chain acyl-CoA dehydrogenase deficiency due to an IVS3+3A>G mutation that causes exon skipping (2006) (38)
- Modeling RNA-Binding Protein Specificity In Vivo by Precisely Registering Protein-RNA Crosslink Sites. (2019) (37)
- A Broad Set of Chromatin Factors Influences Splicing (2016) (36)
- Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice (2018) (36)
- A generalizable pre-clinical research approach for orphan disease therapy (2012) (36)
- Characterization of a SR protein from Trypanosoma brucei with homology to RNA-binding cis-splicing proteins. (1999) (36)
- Spatio-temporal expression of the trans-acting splicing factors SF2/ASF and heterogeneous ribonuclear proteins A1/A1B in the myometrium of the pregnant human uterus: a molecular mechanism for regulating regional protein isoform expression in vivo. (2000) (36)
- An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor. (2002) (35)
- Rescue of gene-expression changes in an induced mouse model of spinal muscular atrophy by an antisense oligonucleotide that promotes inclusion of SMN2 exon 7. (2015) (34)
- Recurrent SRSF2 mutations in MDS affect both splicing and NMD (2020) (34)
- HIV-1 transcription is regulated by splicing factor SRSF1 (2014) (34)
- Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides (2019) (33)
- Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP. (1998) (33)
- Deletion of the N-terminus of SF2/ASF Permits RS-Domain-Independent Pre-mRNA Splicing (2007) (32)
- Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model (2020) (30)
- TSUNAMI: an antisense method to phenocopy splicing-associated diseases in animals. (2012) (30)
- Purification and characterization of human RNPS 1 : a general activator of pre-mRNA splicing (1999) (29)
- Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1. (2002) (29)
- An Exonic Splicing Enhancer in Human IGF-I Pre-mRNA Mediates Recognition of Alternative Exon 5 by the Serine-Arginine Protein Splicing Factor-2/ Alternative Splicing Factor. (2002) (28)
- Downregulation of Survivin contributes to cell-cycle arrest during postnatal cardiac development in a severe spinal muscular atrophy mouse model (2018) (28)
- Splicing therapeutics in SMN2 and APOB. (2009) (28)
- A mutation in a rare type of intron in a sodium‐channel gene results in aberrant splicing and causes myotonia (2011) (25)
- Mapping the SF2/ASF Binding Sites in the Bovine Growth Hormone Exonic Splicing Enhancer* (2000) (25)
- Where in the cell is the minor spliceosome? (2008) (24)
- The U6 small nuclear RNA from Trypanosoma brucei. (1988) (22)
- Evolutionary impact of limited splicing fidelity in mammalian genes. (2007) (22)
- PSI-Sigma: a comprehensive splicing-detection method for short-read and long-read RNA-seq analysis (2019) (21)
- Splicing of mRNA precursors in mammalian cells (1994) (21)
- Abstract 1: Role of the splicing factor SF2/ASF in mammary epithelial cell transformation (2010) (20)
- The Switch in Alternative Splicing of Cyclic AMP-response Element Modulator Protein CREMτ2α (Activator) to CREMα (Repressor) in Human Myometrial Cells Is Mediated by SRp40* (2005) (18)
- Antisense-mediated exon inclusion. (2012) (17)
- The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40. (2005) (16)
- Disruption of splicing-regulatory elements using CRISPR/Cas9 to rescue spinal muscular atrophy in human iPSCs and mice (2019) (16)
- Delivery of GalNAc-Conjugated Splice-Switching ASOs to Non-hepatic Cells through Ectopic Expression of Asialoglycoprotein Receptor (2018) (16)
- RCC1 and nuclear organization. (1997) (15)
- The spliceosome, a potential Achilles heel of MYC-driven tumors (2015) (13)
- Differential 3 9 splice site recognition of SMN 1 and SMN 2 transcripts by U 2 AF and U 2 snRNP (2009) (13)
- Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy (2022) (12)
- Exon-skipping antisense oligonucleotides for cystic fibrosis therapy (2021) (12)
- A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinoma (2017) (12)
- Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy (2021) (11)
- Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia (2021) (11)
- ASO-based PKM splice-switching therapy inhibits hepatocellular carcinoma growth. (2021) (10)
- factors Fox-1 and Fox-2 Defining the regulatory network of the tissue-specific splicing Material Supplemental (2008) (9)
- complexed with single-stranded telomeric DNA Crystal structure of the two-RRM domain of hnRNP A 1 ( UP 1 ) (1999) (9)
- KRAINER splice sites ′ Determinants of the inherent strength of human 5 (2005) (9)
- Functions of SR proteins in the U 12-dependent ATAC pre-mRNA Service Email (2001) (8)
- Identification of SRSF10 as a regulator of SMN2 ISS‐N1 (2020) (7)
- SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia (2020) (7)
- In Vitro Splicing Assays (2012) (7)
- A putative homolog of U2AF65 in S. cerevisiae. (1992) (6)
- Evidence generation and reproducibility in cell and gene therapy research: A call to action (2021) (6)
- Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis (2019) (5)
- A new path to oncogene-induced senescence (2013) (5)
- Crystallization and preliminary X-ray diffraction studies of UP1, the two-RRM domain of hnRNP A1. (1997) (5)
- Long-term storage of concentrated tris-borate-EDTA electrophoresis buffers without precipitation. (1991) (4)
- A splicing component adapted to gene silencing (2009) (4)
- Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing (1989) (4)
- Krainer proteins by individual SR Identification of functional exonic splicing enhancer motifs recognized (1998) (4)
- De novo indels within introns contribute to ASD incidence (2017) (3)
- Splicing therapeutics in SMN 2 and APOB (2013) (3)
- Splicing: still so much to learn (2015) (3)
- Higher-order epistasis and phenotypic prediction (2022) (3)
- The pathology of pre‐mRNA splicing: a meeting in the Italian Alps (2007) (3)
- Correction of RNA Splicing with Antisense Oligonucleotides as a Therapeutic Strategy for a Neurodegenerative Disease (2012) (3)
- Spliceosomal Dysfunction Is a Critical Mediator of IDH2 Mutant Leukemogenesis (2017) (2)
- Antisense-Oligonucleotide Modulation of SMN2 Pre-mRNA Splicing (2017) (2)
- ASO-based PKM Splice-switching Therapy Inhibits Hepatocellular Carcinoma Cell Growth (2020) (2)
- Mechanisms of human β-globin pre-mRNA splicing (1985) (2)
- Systematic characterization of short intronic splicing-regulatory elements in SMN2 pre-mRNA (2022) (2)
- Empirical variance component regression for sequence-function relationships (2020) (1)
- Spinraza Ⓡ : The First Approved Therapy for Spinal Muscular Atrophy (2018) (1)
- Manipulation of alternative splicing by a novel inhibitor of Clks (2004) (1)
- Specificity, synergy, and mechanisms of splice-modifying drugs (2022) (1)
- regulates splicing of specific plant genes , Arabidopsis thaliana atSRp 30 , one of two SF 2 / ASF-like proteins from (1999) (1)
- Non-radioactive detection of m3G capped RNAs by immunoblotting. (1994) (1)
- Exonic Splicing Silencer Element by Binding of hnRNP A/B Proteins to an Splice Site A2 Is Regulated ' Virus Type 1 3 RNA Splicing at Human Immunodeficiency (2013) (1)
- A 1 Antagonistic Effects of SF 2 / ASF and hnRNP of U 1 snRNP and Models for the Splice Sites : Role ′ Selection of Alternative 5 (2000) (1)
- Role of hnRNP A1 structural domains in messenger-RNA splicing and RNA-RNA annealing (1994) (1)
- A putative homology of U2AF65 in S. cerevisiae. (1993) (1)
- UP1, THE TWO RNA-RECOGNITION MOTIF DOMAIN OF HNRNP A1 (1997) (1)
- Simple mutations in the coding region of three acyl-CoA dehydrogenase genes may lead to skipping of the constitutive exon due to disruption of potential splice enhancer sequences or mRNA secondary structures (2002) (1)
- Systematic characterization of short intronic splicing-regulatory elements (2021) (1)
- Defining and characterizing the functions of RS domains in yeast (1996) (1)
- Differential Functions of Splicing Factors in Breast-Cancer Initiation and Metastasis (2019) (1)
- Antisense Oligonucleotide Therapeutics for Cystic Fibrosis: Recent Developments and Perspectives (2023) (0)
- Title Antisense oligonucleotide-induced alternative splicing ofthe APOB mRNA generates a novel isoform of APOB (2017) (0)
- A Conversation with Adrian Krainer. (2020) (0)
- Krainer is a pre-mRNA splicing factor γ The type 2 C Ser / Thr phosphatase PP 2 C (1999) (0)
- Mechanism of Splicing of Unusual Intron in Human Proliferating Cell Nucleolar P120 (1999) (0)
- Nudeotide sequence at the end of the gene for the RNA polymerase 0 ' subunit ( rpoC ) (2005) (0)
- ribonucleoprotein particles . assembly of 40 S heterogeneous nuclear nucleotides of pre-mRNA and nucleates the The C-protein tetramer binds 230 to 240 (0)
- Differential connectivity of splicing activators and repressors to the human spliceosome (2015) (0)
- pre-mRNA splicing . endogenous complexes during in vitro Multiple splicing factors are released from (2003) (0)
- Structure of SRSF1 RRM2 in complex with the RNA 5'-UGAAGGAC-3' (2013) (0)
- Explorer The pathology of pre-mRNA splicing (2018) (0)
- RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer (2023) (0)
- Characterization of a second hnRNP A/B-dependent exonic splicing silencer in protein 4.1R exon 16 (2001) (0)
- Antisense oligonucleotide therapy for H3.3K27M diffuse midline glioma (2023) (0)
- STRUCTURE OF UP1-TELOMERIC DNA COMPLEX (1999) (0)
- Spliceosome-Mediated RNA Splicing Intron-Containing Viral Lytic Genes in and Promotes Expression of ORF 57 Functions as a Viral Splicing Factor Kaposi ' s Sarcoma-Associated Herpesvirus (2008) (0)
- Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer. (2023) (0)
- Abstract A50: Nonredundant functions of splicing factors in breast-cancer initiation and metastasis (2016) (0)
- Towards a combined therapy for spinal muscular atrophy based on opposing effects of an antisense oligonucleotide on chromatin and splicing (2021) (0)
- Global identification of hnRNP A1 binding sites for SSO-based splicing modulation (2016) (0)
- Abstract PR-011: Loss of compensatory feedback mechanism involving splicing factor SRSF1 accelerates KrasG12D-mediated pancreatic cancer initiation (2021) (0)
- Biochemistry of Mammalian Nuclear Pre-Messenger Rna Splicing and Splice Site Selection (1991) (0)
- Kaposi’s Sarcoma-Associated Herpesvirus ORF57 Functions as a Viral Splicing Factor and Promotes Expression of Intron-Containing Viral Lytic Genes in Spliceosome-Mediated RNA Splicing (cid:1) (2008) (0)
- The control of splicing factor recruitment to sites of transcription in-vivo (1997) (0)
- Edinburgh Research Explorer The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation (2017) (0)
- RNA therapeutics (2023) (0)
- Finding exons in a sea of introns: the nature and function of exonic splicing enhancers (1999) (0)
- Oligonucleotide therapeutics for correcting defective RNA splicing (2011) (0)
- Preclinical Screening of Splice-Switching Antisense Oligonucleotides in PDAC Organoids (2023) (0)
- Nonsense-Mediated Alternative Splicing (2006) (0)
- The spliceosome, a potential Achilles heel of MYC-driven tumors (2015) (0)
- Voltage-Gated Ion Channel Genes Conservation of Minor Introns in AT-AC Pre-mRNA Splicing Mechanisms and (2013) (0)
- Talk from Adrian Krainer at the Cold Spring Harbor Laboratory In-House Symposium (2011) (2011) (0)
- Abstracts of papers presented at the 1997 meeting on Eukaryotic mRNA Processing August 20-August 24, 1997 (1997) (0)
- MN14 Binding to a novel RNA-protein complex creates specificity for small molecule splicing modifiers to treat SMA (2017) (0)
- The spliceosome and the regulation of alternative splicing. (2016) (0)
- Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers (2017) (0)
- Quantitative Activity Profi le and Context Dependence of All Human 5 0 Splice Sites Graphical (2018) (0)
- Spliceosome: Physiology and Disease Pathogenesis (2016) (0)
- a yeast splicing factor . A human protein required for the second step of pre-mRNA splicing (2007) (0)
- Loss of KRASG12D feedback regulation involving splicing factor SRSF1 accelerates pancreatic cancer (2021) (0)
- Abstract 4854: PKM2 Modulates hepatic macrophage regulation of NASH, ferroptosis and HCC through TGF-β signaling (2023) (0)
- Developmental changes in hnRNP A/B protein expression during erythropoiesis regulate Protein 4.1R alternative pre-mRNA splicing (2001) (0)
- Abstracts of papers presented at the 1993 Meeting on RNA Processing, May 19-May 23, 1993 (1993) (0)
- TARGETING NONSENSE-MEDIATED MRNA DECAY FOR CYSTIC FIBROSIS THERAPY (2019) (0)
- Modulation of Exon Skipping and Inclusion by Heterogeneous Nuclear Ribonucleoprotein A1 and Pre-mRNA Splicing Factor SF2/ASF (1993) (0)
- Spinraza (cid:0) : The First Approved Therapy for Spinal Muscular Atrophy (2020) (0)
- Molecules chimeres servant a moduler l'expression d'un gene (2001) (0)
- from HeLa cells . Purification and characterization of pre-mRNA splicing factor SF 2 (2007) (0)
- Author Correction: Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia (2021) (0)
- Sequences and factors involved in pre-mRNA splicing in vitro (1985) (0)
- DNA-binding protein p54nrb/NonO. transcription and is identical to the RNA- and enhancer-binding protein activates The intracisternal A-particle proximal (2014) (0)
- Therapeutic Targeting of an RNA Splicing Factor Network for the Treatment of Myeloid Neoplasms (2018) (0)
- RNA & OLIGONUCLEOTIDE THERAPEUTICS (2010) (0)
- Specificity, cooperativity, synergy, and mechanisms of splice-modifying drugs. (2023) (0)
- Abstract B53: Differential functions of splicing factors in breast-cancer initiation and metastasis (2013) (0)
- Systemic Versus CNS Delivery Of MOE Antisense Oligonucleotide to Correct Defective Splicing in a Severe Mouse Model of Spinal Muscular Atrophy (2011) (0)
- Pre-mRNA Splicing Mechanisms, Misregulation in Disease, and Therapeutic Strategies (2012) (0)
- Syddansk Universitet Global identification of hnRNP A 1 binding sites for SSO-based splicing modulation (2016) (0)
- Krainer cytoplasm nucleus and the A specific subset of SR proteins shuttles continuously between the (1997) (0)
- Abstract A078: Differential functions of splicing factors in breast cancer initiation and metastasis (2013) (0)
- mutation pattern, nucleotide structure and comparison of computational tools that predict (2007) (0)
- Composite Pre-mRNA Exonic Elements Their RNA Recognition Motifs and Constitutive Splicing Are Determined by Substrate Specificities of SR Proteins in (1999) (0)
- Abstracts of papers presented at the 1999 Meeting on Eukaryotic mRNA Processing, August 25-August 29, 1999 (1999) (0)
- Oncogenic Activity of Alternative Splicing Factors (2006) (0)
- Modulation of Gene Expression By Oligonucleotide Chemistry-Dependent Recruitment of Proteins to RNA Transcripts (2011) (0)
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