Afshin Samali
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Computer Science
Afshin Samali's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
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(Suggest an Edit or Addition)Afshin Samali's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- Mediators of endoplasmic reticulum stress‐induced apoptosis (2006) (2136)
- The integrated stress response (2016) (1322)
- Triggering and modulation of apoptosis by oxidative stress. (2000) (1293)
- Cellular Stress Responses: Cell Survival and Cell Death (2010) (1152)
- The eIF2α kinases: their structures and functions (2013) (581)
- PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress (2012) (579)
- Presence of a pre‐apoptotic complex of pro‐caspase‐3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells (1999) (542)
- Heat shock proteins increase resistance to apoptosis. (1996) (541)
- On the role of Hsp27 in regulating apoptosis (2004) (507)
- Endoplasmic reticulum stress signalling – from basic mechanisms to clinical applications (2018) (436)
- Caspases: their intracellular localization and translocation during apoptosis (1999) (354)
- Stress management at the ER: regulators of ER stress-induced apoptosis. (2012) (328)
- Caspase-12 and ER-stress-mediated apoptosis: the story so far. (2003) (320)
- Heat shock proteins: regulators of stress response and apoptosis. (1998) (313)
- Losing heart: the role of apoptosis in heart disease—a novel therapeutic target? (2002) (310)
- Targeting the endoplasmic reticulum-stress response as an anticancer strategy. (2009) (305)
- Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders (2011) (292)
- TRAIL receptor signalling and modulation: Are we on the right TRAIL? (2009) (289)
- Caspase‐12 and ER‐Stress‐Mediated Apoptosis (2003) (276)
- Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. (2015) (269)
- Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response (2010) (268)
- Bcl-2 family on guard at the ER. (2009) (252)
- New directions in ER stress-induced cell death (2013) (246)
- Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress (2013) (240)
- HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction (2010) (240)
- Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c. (2001) (230)
- Apoptosis: Cell death defined by caspase activation (1999) (226)
- A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis. (1999) (216)
- Cleavage of the calpain inhibitor, calpastatin, during apoptosis (1998) (212)
- Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response (2017) (203)
- ER stress contributes to ischemia-induced cardiomyocyte apoptosis. (2006) (193)
- The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress (2012) (192)
- Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor. (2006) (191)
- Metabolic Flexibility Permits Mesenchymal Stem Cell Survival in an Ischemic Environment (2008) (180)
- Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli (2001) (179)
- Stressed to death - mechanisms of ER stress-induced cell death. (2014) (174)
- The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance (2018) (165)
- Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling. (2005) (157)
- Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy (2018) (154)
- Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression. (1999) (152)
- Antioxidant‐mediated inhibition of the heat shock response leads to apoptosis (1999) (151)
- The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling. (2017) (138)
- Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins (1999) (133)
- Endoplasmic Reticulum Stress and the Unfolded Protein Response: Targeting the Achilles Heel of Multiple Myeloma (2013) (133)
- An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro. (2011) (124)
- Dual IRE1 RNase functions dictate glioblastoma development (2018) (121)
- Ischemia/reperfusion injury at the intersection with cell death. (2005) (115)
- Don't lose heart ‐ therapeutic value of apoptosis prevention in the treatment of cardiovascular disease (2005) (111)
- Regulation of apoptosis by heat shock proteins (2014) (109)
- Structural determinants of DISC function: new insights into death receptor-mediated apoptosis signalling. (2013) (101)
- Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells (2015) (101)
- Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells. (2005) (97)
- Increased Expression of Endoplasmic Reticulum Stress-Related Signaling Pathway Molecules in Multiple Sclerosis Lesions (2008) (95)
- Detection of pro‐caspase‐3 in cytosol and mitochondria of various tissues (1998) (94)
- Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts. (2018) (90)
- Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis (2012) (89)
- Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL (2007) (87)
- Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization (2010) (86)
- Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants (2010) (82)
- Controlling the unfolded protein response-mediated life and death decisions in cancer. (2015) (81)
- Tumour Cell Secretome in Chemoresistance and Tumour Recurrence. (2020) (77)
- Anti-oxidants and apoptosis. (1996) (73)
- DR4-selective Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Variants Obtained by Structure-based Design* (2008) (72)
- Heat shock protects PC12 cells against MPP+ toxicity (2003) (69)
- Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways (2013) (68)
- Addicted to secrete - novel concepts and targets in cancer therapy. (2014) (67)
- Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model (2009) (66)
- Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival (2016) (64)
- Apoptosis-the story so far... (1996) (59)
- Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response. (2015) (59)
- Cytokine-induced β-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL (2007) (58)
- Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity (2016) (56)
- Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells. (1997) (56)
- Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidase. (2007) (56)
- The Unfolded Protein Response in Breast Cancer (2018) (56)
- Novel roles of the unfolded protein response in the control of tumor development and aggressiveness. (2015) (54)
- Stem cells are resistant to TRAIL receptor-mediated apoptosis (2008) (51)
- Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions (2014) (50)
- Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells (2011) (48)
- A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy. (2015) (47)
- The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors (2019) (47)
- Regulation of lipid metabolism by the unfolded protein response (2021) (47)
- Cellular longevity: role of apoptosis and replicative senescence (2004) (47)
- The switch from survival responses to apoptosis after chromosomal breaks. (2004) (45)
- Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation (2019) (44)
- Assays for detecting the unfolded protein response. (2011) (44)
- Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells (2010) (42)
- Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner (2014) (41)
- Enhancement of antitumor properties of rhTRAIL by affinity increase toward its death receptors. (2009) (39)
- Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines (2009) (38)
- TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt (2006) (38)
- Regulation of the unfolded protein response by noncoding RNA. (2017) (38)
- Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins. (2006) (37)
- Methods for studying ER stress and UPR markers in human cells. (2015) (37)
- Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim. (2013) (36)
- Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases. (2019) (35)
- In the cut and thrust of apoptosis, serine proteases come of age. (2003) (34)
- Bisphenol A-Mediated Suppression of LPL Gene Expression Inhibits Triglyceride Accumulation during Adipogenic Differentiation of Human Adult Stem Cells (2012) (34)
- PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response (2015) (34)
- Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
- Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion (2013) (32)
- NOXA contributes to the sensitivity of PERK‐deficient cells to ER stress (2012) (32)
- beta cell cytoprotective strategies: establishing the relative roles for iNOS and ROS. (2006) (32)
- Endoplasmic reticulum stress: at the crossroads of inflammation and metabolism in hepatocellular carcinoma development. (2014) (31)
- Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652 (2016) (31)
- Is There a Role for Nuclear Factor κB in Tumor Necrosis Factor‐Related Apoptosis‐Inducing Ligand Resistance? (2009) (31)
- The ability to cleave 28S ribosomal RNA during apoptosis is a cell-type dependent trait unrelated to DNA fragmentation (1997) (29)
- Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells (2020) (29)
- Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL (2006) (29)
- HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis (2017) (29)
- Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL* (2012) (29)
- Cell Stress and Cell Death (2010) (29)
- Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML (2018) (28)
- miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts (2014) (27)
- Determination of Apoptosis and Necrosis (1999) (27)
- Targeting AML through DR4 with a novel variant of rhTRAIL (2011) (26)
- RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions (2014) (25)
- Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β (2019) (25)
- Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine. (2006) (24)
- RIP2 enhances cell survival by activation of NF-ĸB in triple negative breast cancer cells. (2018) (24)
- Interleukin-1, interleukin-8, tumour necrosis factor alpha and interferon gamma stimulate DNA synthesis but have no effect on apoptosis in small-intestinal cell lines (2001) (24)
- Synthetic constrained peptide selectively binds and antagonizes death receptor 5 (2010) (23)
- Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo. (2020) (22)
- The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL-induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells (2016) (22)
- Drugging the unfolded protein response in acute leukemias (2015) (22)
- An Emerging Role for the Unfolded Protein Response in Pancreatic Cancer (2021) (20)
- Current Concepts in ER Stress-Induced Apoptosis (2013) (20)
- ER stress in obesity pathogenesis and management. (2021) (19)
- RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions (2014) (18)
- The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis (2011) (18)
- Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM (2014) (18)
- Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors (2019) (18)
- Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion viaregulation of Bim (2008) (17)
- Cytoprotection of beta cells: rational gene transfer strategies (2006) (16)
- Decorated macrocycles via ring-closing double-reductive amination. identification of an apoptosis inducer of leukemic cells that at least partially antagonizes a 5-HT2 receptor. (2015) (16)
- Autophagy, Apoptosis, the Unfolded Protein Response, and Lung Function in Idiopathic Pulmonary Fibrosis (2021) (15)
- Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation (2007) (15)
- Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats. (2012) (15)
- Induction of Autophagy: Role of Endoplasmic Reticulum Stress and Unfolded Protein Response (2015) (14)
- RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions (2015) (13)
- Biology of the Endoplasmic Reticulum (2020) (13)
- Hypoxia and Ischemia Induce Nuclear Condensation and Caspase Activation in Cardiomyocytes (2003) (13)
- Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer (2022) (13)
- Role of Bcr-Abl kinase in resistance to apoptosis. (1997) (12)
- CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization (2005) (12)
- Homology model of the human tRNA splicing ligase RtcB (2017) (11)
- Peptidomimetic‐based identification of FDA‐approved compounds inhibiting IRE1 activity (2020) (11)
- Cytokine-Induced β-Cell Stress and Death in Type 1 Diabetes Mellitus (2011) (11)
- Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1 (2019) (10)
- BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1. (2015) (9)
- Heat Shock Proteins and the Regulation of Apoptosis (2009) (9)
- Title Endoplasmic reticulum stress induces ligand-independentTNFR 1-mediated necroptosis in L 929 cells (2018) (9)
- The IRE1 and PERK arms of the unfolded protein response promote survival of rhabdomyosarcoma cells. (2020) (9)
- Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity. (2018) (8)
- Atypical heat shock response and acquisition of thermotolerance in P388D1 cells. (2013) (7)
- Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain (2018) (7)
- The stressosome, a caspase‐8‐activating signalling complex assembled in response to cell stress in an ATG5‐mediated manner (2021) (7)
- The Role of BiP and the IRE1α–XBP1 Axis in Rhabdomyosarcoma Pathology (2021) (6)
- Targeting the angio-proteostasis network: Combining the forces against cancer. (2016) (6)
- Targeting of BCR-ABL1 and IRE1α induces synthetic lethality in Philadelphia-positive acute lymphoblastic leukemia. (2020) (6)
- OxLDL-induced gene expression patterns in CASMC are mimicked in apoE-/- mice aortas. (2007) (6)
- Measurement of Cell Death in Culture (1999) (5)
- Gold(I) Complexes with a Quinazoline Carboxamide Alkynyl Ligand: Synthesis, Cytotoxicity, and Mechanistic Studies (2021) (5)
- Effect of Kinase Inhibiting RNase Attenuator (KIRA) Compounds on the Formation of Face-to-Face Dimers of Inositol-Requiring Enzyme 1: Insights from Computational Modeling (2019) (5)
- ER stress responses in the absence of apoptosome: a comparative study in CASP9 proficient vs deficient mouse embryonic fibroblasts. (2014) (4)
- The Role of Hsps in Neuronal Differentiation and Development (2009) (4)
- Quality status of brands of chloroquine tablet dosa ge form from Northern part of Nigeria (2014) (4)
- 40- to 100-kD Protein(s) of Helicobacter pylori Stimulate DNA Synthesis in Epithelial Cell Lines without Affecting Apoptosis (2000) (4)
- Mechanisms of Resistance to Cell Death Pathways in Cancer Cells (2014) (4)
- Novel Pt(IV) Pro-drugs Displaying Antimitochondrial Effects. (2020) (4)
- Correction to An Unfractionated Fucoidan from Ascophyllum nodosum: Extraction, Characterization, and Apoptotic Effects in Vitro (2012) (4)
- Current Concepts in Cell Toxicity (1999) (4)
- New directions in ER stress-induced cell death (2013) (3)
- Development of a novel preclinical glioblastoma mouse model and therapeutic impact of IRE1 inhibition (2019) (3)
- Downregulation of miR-17-92 Cluster by PERK Fine-Tunes Unfolded Protein Response Mediated Apoptosis (2020) (3)
- Synergistic Dual Inhibition of BCR-ABL1 and the Unfolded Protein Response Causes p38 MAPK-Mediated Cell Death and Sensitizes BCR-ABL1+ Acute Lymphoblastic Leukemia to Dexamethasone (2018) (2)
- Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells. (2017) (2)
- Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress (2012) (2)
- G2/M Arrest Sensitises Erythroid Leukemia Cells to TRAIL-induced Apoptosis (2015) (2)
- ER Stress Signaling Pathways in Cell Survival and Death (2012) (2)
- Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy (2018) (2)
- A TRIBUTE TO Professor Richard A. Lockshin on his 70th birthday (2007) (2)
- Apoptosis: a mapped path to cell death (2007) (2)
- Control of glioblastoma differentiated-to-stem cell reprogramming by IRElα/XBPls signaling (2019) (1)
- Application of a New Multiplexed Array for Rapid, Sensitive, Simultaneous and Quantitative Assessment of Spliced and Unspliced XBP1 (2019) (1)
- PERK IS REQUIRED AT THE ER-TO-MITOCHONDRIA CONTACT SITES TO CONVEY APOPTOSIS FOLLOWING ROS-MEDIATED ER STRESS (2012) (1)
- The BH3 Mimetic, ABT-737, Overcomes Stromal-Mediated Pro-Survival Signals and Synergizes with PHA-767491, a Dual Cdc7/CDK9 Inhibitor, In Acute Myeloid Leukaemia (2010) (1)
- Decoy-insensitive TRAIL variants kill tumour cells more efficiently without damaging non-transformed cells (2007) (1)
- Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph+ leukemia (2016) (1)
- Constitutive UPRER activation sustains tumor cell differentiation (2019) (1)
- Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells (2017) (1)
- Local intracerebral Inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo (2020) (1)
- PERK deficiency distorts the ER-mitochondrial interface and protects against ROS-induced intrinsic apoptosis (2010) (1)
- G2/M Arrest Sensitizes Chronic Myelogenous Leukemia Cells to TRAIL-Induced Apoptosis (2010) (1)
- miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts (2014) (1)
- Unfolded protein response at the cross roads of tumourigenesis, oxygen sensing and drug resistance in clear cell renal cell carcinoma. (2022) (1)
- Loss of Dicer1 in mouse embryonic fibroblasts impairs ER stress-induced apoptosis (2015) (1)
- Maintenance of Endoplasmic Reticulum Protein Homeostasis in Cancer: Friend or Foe. (2021) (1)
- Inhibition of IRE1α RNase activity sensitizes patient‐derived acute myeloid leukaemia cells to proteasome inhibitors (2022) (1)
- Editorial: Cell stress and cell death (2010) (1)
- Endoplasmic Reticulum Stress-Regulated Chaperones as a Serum Biomarker Panel for Parkinson’s Disease (2022) (1)
- Constitutive IRE1α signaling maintains glioblastoma cell differentiation (2019) (0)
- Title Bisphenol A-Mediated Suppression of LPL Gene Expression Inhibits Triglyceride Accumulation during Adipogenic Differentiation of Human Adult Stem Cells (2019) (0)
- Structural distortions induced by Kinase Inhibiting RNase Attenuator (KIRA) compounds prevent the formation of face-to-face dimers of Inositol Requiring Enzyme 1α (2019) (0)
- 505 Dual Cdc7/Cdk9 kinase inhibitor, PHA-767491, targets both quiescent and proliferating CLL cells (2010) (0)
- OS1.8 IRE1-mediated immunomodulation in glioblastoma. (2016) (0)
- 12 Cytokine-Induced-Cell Stress and Death in Type 1 Diabetes Mellitus (2012) (0)
- DESIGNED RECEPTOR SPECIFIC RHTRAIL VARIANTS ENHANCE INDUCTION OF APOPTOSIS IN CANCER CELLS (2011) (0)
- Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL (2019) (0)
- Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML (2018) (0)
- PERK is an essential component of the ER-to-mitochondria contact sites required to convey mitochondrial apoptosis following ROS-mediated ER stress (2011) (0)
- PHA767491, a Dual Cdc7/CDK9 Inhibitor, with Potential to Target Both Proliferation and Survival in CLL. (2009) (0)
- PERK is a component of the mitochondria-associated membranes that shapes ER-mitochondria interactions during ER stress (2013) (0)
- Dual IRE1 RNase functions dictate glioblastoma development (2023) (0)
- University of Groningen Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model Duiker, (2022) (0)
- Title Methods for Monitoring Endoplasmic Reticulum Stress and theUnfolded Protein Response (2017) (0)
- Abstracts of the Royal Academy of Medicine in Ireland Section of Biomedical Sciences Annual Meeting 2012. June 14, 2012. Galway, Ireland. (2013) (0)
- Uncovering new roles of the endoplasmic reticulum stress kinase PERK beyond the unfolded protein response (2014) (0)
- Heat shock proteins protect PC12 cells from MPP+ toxicity (2002) (0)
- Correction: Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells (2018) (0)
- Dual IRE1 RNase functions dictate glioblastoma development (2022) (0)
- Decorated macrocycles via ring-closing double-reductive amination. Identification of an apoptosis inducer of leukemic cells that antagonizes a 5-HT2 via Ring-Closing Double-Reductive Amination. (2018) (0)
- Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors (2019) (0)
- The eIF2α kinases: their structures and functions (2013) (0)
- Royal academy of medicine in Ireland (0)
- 550. Adenoviral-Mediated Antioxidant Overexpression: Possible Protective Role Against Hyperglycemic Conditions in Human Aortic Endothelial Cells (2005) (0)
- Cytokine design: US Patent 7,994,281 (2011) (0)
- Trail variants for treating cancer: World Patent WO/2009/077,857 (2009) (0)
- Improved cytokine design: European Patent 2,224,944 (2010) (0)
- New insights into IRE1α activation and function in anti-tumor immunity (2022) (0)
- Correction: Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β (2020) (0)
- Correction: Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β (2020) (0)
- IMPROVED TUMOR CELL KILLING BY TRAIL REQUIRES SELECTIVE AND HIGH AFFINITY RECEPTOR ACTIVATION (2011) (0)
- Cytokine design: US patent App. 12/744,069 (2008) (0)
- COMPUTATIONAL DESIGN OF RECEPTOR SELECTIVE TRAIL VARIANTS (2011) (0)
- Application of a New Multiplexed Array for Rapid, Sensitive, Simultaneous and Quantitative Assessment of Spliced and Unspliced XBP1 (2019) (0)
- The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors (2019) (0)
- Role of antioxidants in the regulation of stress response (1998) (0)
- Preclinical Combination of a Novel Ire1 Rnase Inhibitor Mkc-8866 and Tyrosine Kinase Inhibition Acts Synergistic in Acute Lymphoblastic Leukemia (2017) (0)
- Regulation of Apoptosis by Heat Shock Proteins Donna Kennedy 1 (2014) (0)
- Using omics approaches to develop a biomarker signature for anti-psychotic drug toxicity (2018) (0)
- Conception de cytokine améliorée (2008) (0)
- PERK deficiency protects against ROS-mediated cell death by impairing the induction of pro-apoptotic UPR target genes (2009) (0)
- ENHANCED ANTI-TUMOR EFFICACY OF A DR5-SPECIFIC TRAIL VARIANT OVER RHTRAIL IN A BIOLUMINESCENT OVARIAN CANCER XENOGRAFT MODEL (2011) (0)
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