Afshin Samali

Q: What Schools Are Affiliated With Afshin Samali

Afshin Samali is affiliated with the following schools: Karolinska Institute, National University of Ireland, Queen's University Belfast, University of California, Berkeley, University of Oxford, Stanford University

Afshin Samali's AcademicInfluence.com Rankings

Afshin Samali

Computer Science

#8269

World Rank

#8694

Historical Rank

Computational Linguistics

#1807

World Rank

#1826

Historical Rank

Machine Learning

#3342

World Rank

#3382

Historical Rank

Artificial Intelligence

#3641

World Rank

#3693

Historical Rank

computer-science Degrees

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Computer Science

Afshin Samali's Degrees

PhD Computer Science Stanford University
Masters Computer Science University of California, Berkeley
Bachelors Computer Science University of California, Berkeley

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Afshin Samali's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
Mediators of endoplasmic reticulum stress‐induced apoptosis (2006) (2136)
The integrated stress response (2016) (1322)
Triggering and modulation of apoptosis by oxidative stress. (2000) (1293)
Cellular Stress Responses: Cell Survival and Cell Death (2010) (1152)
The eIF2α kinases: their structures and functions (2013) (581)
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress (2012) (579)
Presence of a pre‐apoptotic complex of pro‐caspase‐3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells (1999) (542)
Heat shock proteins increase resistance to apoptosis. (1996) (541)
On the role of Hsp27 in regulating apoptosis (2004) (507)
Endoplasmic reticulum stress signalling – from basic mechanisms to clinical applications (2018) (436)
Caspases: their intracellular localization and translocation during apoptosis (1999) (354)
Stress management at the ER: regulators of ER stress-induced apoptosis. (2012) (328)
Caspase-12 and ER-stress-mediated apoptosis: the story so far. (2003) (320)
Heat shock proteins: regulators of stress response and apoptosis. (1998) (313)
Losing heart: the role of apoptosis in heart disease—a novel therapeutic target? (2002) (310)
Targeting the endoplasmic reticulum-stress response as an anticancer strategy. (2009) (305)
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders (2011) (292)
TRAIL receptor signalling and modulation: Are we on the right TRAIL? (2009) (289)
Caspase‐12 and ER‐Stress‐Mediated Apoptosis (2003) (276)
Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. (2015) (269)
Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response (2010) (268)
Bcl-2 family on guard at the ER. (2009) (252)
New directions in ER stress-induced cell death (2013) (246)
Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress (2013) (240)
HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction (2010) (240)
Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c. (2001) (230)
Apoptosis: Cell death defined by caspase activation (1999) (226)
A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis. (1999) (216)
Cleavage of the calpain inhibitor, calpastatin, during apoptosis (1998) (212)
Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response (2017) (203)
ER stress contributes to ischemia-induced cardiomyocyte apoptosis. (2006) (193)
The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress (2012) (192)
Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor. (2006) (191)
Metabolic Flexibility Permits Mesenchymal Stem Cell Survival in an Ischemic Environment (2008) (180)
Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli (2001) (179)
Stressed to death - mechanisms of ER stress-induced cell death. (2014) (174)
The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance (2018) (165)
Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling. (2005) (157)
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy (2018) (154)
Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression. (1999) (152)
Antioxidant‐mediated inhibition of the heat shock response leads to apoptosis (1999) (151)
The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling. (2017) (138)
Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins (1999) (133)
Endoplasmic Reticulum Stress and the Unfolded Protein Response: Targeting the Achilles Heel of Multiple Myeloma (2013) (133)
An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro. (2011) (124)
Dual IRE1 RNase functions dictate glioblastoma development (2018) (121)
Ischemia/reperfusion injury at the intersection with cell death. (2005) (115)
Don't lose heart ‐ therapeutic value of apoptosis prevention in the treatment of cardiovascular disease (2005) (111)
Regulation of apoptosis by heat shock proteins (2014) (109)
Structural determinants of DISC function: new insights into death receptor-mediated apoptosis signalling. (2013) (101)
Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells (2015) (101)
Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells. (2005) (97)
Increased Expression of Endoplasmic Reticulum Stress-Related Signaling Pathway Molecules in Multiple Sclerosis Lesions (2008) (95)
Detection of pro‐caspase‐3 in cytosol and mitochondria of various tissues (1998) (94)
Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts. (2018) (90)
Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis (2012) (89)
Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL (2007) (87)
Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization (2010) (86)
Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants (2010) (82)
Controlling the unfolded protein response-mediated life and death decisions in cancer. (2015) (81)
Tumour Cell Secretome in Chemoresistance and Tumour Recurrence. (2020) (77)
Anti-oxidants and apoptosis. (1996) (73)
DR4-selective Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Variants Obtained by Structure-based Design* (2008) (72)
Heat shock protects PC12 cells against MPP+ toxicity (2003) (69)
Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways (2013) (68)
Addicted to secrete - novel concepts and targets in cancer therapy. (2014) (67)
Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model (2009) (66)
Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival (2016) (64)
Apoptosis-the story so far... (1996) (59)
Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response. (2015) (59)
Cytokine-induced β-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL (2007) (58)
Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity (2016) (56)
Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells. (1997) (56)
Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidase. (2007) (56)
The Unfolded Protein Response in Breast Cancer (2018) (56)
Novel roles of the unfolded protein response in the control of tumor development and aggressiveness. (2015) (54)
Stem cells are resistant to TRAIL receptor-mediated apoptosis (2008) (51)
Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions (2014) (50)
Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells (2011) (48)
A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy. (2015) (47)
The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors (2019) (47)
Regulation of lipid metabolism by the unfolded protein response (2021) (47)
Cellular longevity: role of apoptosis and replicative senescence (2004) (47)
The switch from survival responses to apoptosis after chromosomal breaks. (2004) (45)
Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation (2019) (44)
Assays for detecting the unfolded protein response. (2011) (44)
Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells (2010) (42)
Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner (2014) (41)
Enhancement of antitumor properties of rhTRAIL by affinity increase toward its death receptors. (2009) (39)
Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines (2009) (38)
TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt (2006) (38)
Regulation of the unfolded protein response by noncoding RNA. (2017) (38)
Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins. (2006) (37)
Methods for studying ER stress and UPR markers in human cells. (2015) (37)
Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim. (2013) (36)
Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases. (2019) (35)
In the cut and thrust of apoptosis, serine proteases come of age. (2003) (34)
Bisphenol A-Mediated Suppression of LPL Gene Expression Inhibits Triglyceride Accumulation during Adipogenic Differentiation of Human Adult Stem Cells (2012) (34)
PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response (2015) (34)
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion (2013) (32)
NOXA contributes to the sensitivity of PERK‐deficient cells to ER stress (2012) (32)
beta cell cytoprotective strategies: establishing the relative roles for iNOS and ROS. (2006) (32)
Endoplasmic reticulum stress: at the crossroads of inflammation and metabolism in hepatocellular carcinoma development. (2014) (31)
Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652 (2016) (31)
Is There a Role for Nuclear Factor κB in Tumor Necrosis Factor‐Related Apoptosis‐Inducing Ligand Resistance? (2009) (31)
The ability to cleave 28S ribosomal RNA during apoptosis is a cell-type dependent trait unrelated to DNA fragmentation (1997) (29)
Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells (2020) (29)
Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL (2006) (29)
HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis (2017) (29)
Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL* (2012) (29)
Cell Stress and Cell Death (2010) (29)
Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML (2018) (28)
miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts (2014) (27)
Determination of Apoptosis and Necrosis (1999) (27)
Targeting AML through DR4 with a novel variant of rhTRAIL (2011) (26)
RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions (2014) (25)
Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β (2019) (25)
Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine. (2006) (24)
RIP2 enhances cell survival by activation of NF-ĸB in triple negative breast cancer cells. (2018) (24)
Interleukin-1, interleukin-8, tumour necrosis factor alpha and interferon gamma stimulate DNA synthesis but have no effect on apoptosis in small-intestinal cell lines (2001) (24)
Synthetic constrained peptide selectively binds and antagonizes death receptor 5 (2010) (23)
Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo. (2020) (22)
The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL-induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells (2016) (22)
Drugging the unfolded protein response in acute leukemias (2015) (22)
An Emerging Role for the Unfolded Protein Response in Pancreatic Cancer (2021) (20)
Current Concepts in ER Stress-Induced Apoptosis (2013) (20)
ER stress in obesity pathogenesis and management. (2021) (19)
RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions (2014) (18)
The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis (2011) (18)
Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM (2014) (18)
Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors (2019) (18)
Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion viaregulation of Bim (2008) (17)
Cytoprotection of beta cells: rational gene transfer strategies (2006) (16)
Decorated macrocycles via ring-closing double-reductive amination. identification of an apoptosis inducer of leukemic cells that at least partially antagonizes a 5-HT2 receptor. (2015) (16)
Autophagy, Apoptosis, the Unfolded Protein Response, and Lung Function in Idiopathic Pulmonary Fibrosis (2021) (15)
Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation (2007) (15)
Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats. (2012) (15)
Induction of Autophagy: Role of Endoplasmic Reticulum Stress and Unfolded Protein Response (2015) (14)
RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions (2015) (13)
Biology of the Endoplasmic Reticulum (2020) (13)
Hypoxia and Ischemia Induce Nuclear Condensation and Caspase Activation in Cardiomyocytes (2003) (13)
Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer (2022) (13)
Role of Bcr-Abl kinase in resistance to apoptosis. (1997) (12)
CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization (2005) (12)
Homology model of the human tRNA splicing ligase RtcB (2017) (11)
Peptidomimetic‐based identification of FDA‐approved compounds inhibiting IRE1 activity (2020) (11)
Cytokine-Induced β-Cell Stress and Death in Type 1 Diabetes Mellitus (2011) (11)
Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1 (2019) (10)
BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1. (2015) (9)
Heat Shock Proteins and the Regulation of Apoptosis (2009) (9)
Title Endoplasmic reticulum stress induces ligand-independentTNFR 1-mediated necroptosis in L 929 cells (2018) (9)
The IRE1 and PERK arms of the unfolded protein response promote survival of rhabdomyosarcoma cells. (2020) (9)
Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity. (2018) (8)
Atypical heat shock response and acquisition of thermotolerance in P388D1 cells. (2013) (7)
Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain (2018) (7)
The stressosome, a caspase‐8‐activating signalling complex assembled in response to cell stress in an ATG5‐mediated manner (2021) (7)
The Role of BiP and the IRE1α–XBP1 Axis in Rhabdomyosarcoma Pathology (2021) (6)
Targeting the angio-proteostasis network: Combining the forces against cancer. (2016) (6)
Targeting of BCR-ABL1 and IRE1α induces synthetic lethality in Philadelphia-positive acute lymphoblastic leukemia. (2020) (6)
OxLDL-induced gene expression patterns in CASMC are mimicked in apoE-/- mice aortas. (2007) (6)
Measurement of Cell Death in Culture (1999) (5)
Gold(I) Complexes with a Quinazoline Carboxamide Alkynyl Ligand: Synthesis, Cytotoxicity, and Mechanistic Studies (2021) (5)
Effect of Kinase Inhibiting RNase Attenuator (KIRA) Compounds on the Formation of Face-to-Face Dimers of Inositol-Requiring Enzyme 1: Insights from Computational Modeling (2019) (5)
ER stress responses in the absence of apoptosome: a comparative study in CASP9 proficient vs deficient mouse embryonic fibroblasts. (2014) (4)
The Role of Hsps in Neuronal Differentiation and Development (2009) (4)
Quality status of brands of chloroquine tablet dosa ge form from Northern part of Nigeria (2014) (4)
40- to 100-kD Protein(s) of Helicobacter pylori Stimulate DNA Synthesis in Epithelial Cell Lines without Affecting Apoptosis (2000) (4)
Mechanisms of Resistance to Cell Death Pathways in Cancer Cells (2014) (4)
Novel Pt(IV) Pro-drugs Displaying Antimitochondrial Effects. (2020) (4)
Correction to An Unfractionated Fucoidan from Ascophyllum nodosum: Extraction, Characterization, and Apoptotic Effects in Vitro (2012) (4)
Current Concepts in Cell Toxicity (1999) (4)
New directions in ER stress-induced cell death (2013) (3)
Development of a novel preclinical glioblastoma mouse model and therapeutic impact of IRE1 inhibition (2019) (3)
Downregulation of miR-17-92 Cluster by PERK Fine-Tunes Unfolded Protein Response Mediated Apoptosis (2020) (3)
Synergistic Dual Inhibition of BCR-ABL1 and the Unfolded Protein Response Causes p38 MAPK-Mediated Cell Death and Sensitizes BCR-ABL1+ Acute Lymphoblastic Leukemia to Dexamethasone (2018) (2)
Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells. (2017) (2)
Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress (2012) (2)
G2/M Arrest Sensitises Erythroid Leukemia Cells to TRAIL-induced Apoptosis (2015) (2)
ER Stress Signaling Pathways in Cell Survival and Death (2012) (2)
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy (2018) (2)
A TRIBUTE TO Professor Richard A. Lockshin on his 70th birthday (2007) (2)
Apoptosis: a mapped path to cell death (2007) (2)
Control of glioblastoma differentiated-to-stem cell reprogramming by IRElα/XBPls signaling (2019) (1)
Application of a New Multiplexed Array for Rapid, Sensitive, Simultaneous and Quantitative Assessment of Spliced and Unspliced XBP1 (2019) (1)
PERK IS REQUIRED AT THE ER-TO-MITOCHONDRIA CONTACT SITES TO CONVEY APOPTOSIS FOLLOWING ROS-MEDIATED ER STRESS (2012) (1)
The BH3 Mimetic, ABT-737, Overcomes Stromal-Mediated Pro-Survival Signals and Synergizes with PHA-767491, a Dual Cdc7/CDK9 Inhibitor, In Acute Myeloid Leukaemia (2010) (1)
Decoy-insensitive TRAIL variants kill tumour cells more efficiently without damaging non-transformed cells (2007) (1)
Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph+ leukemia (2016) (1)
Constitutive UPRER activation sustains tumor cell differentiation (2019) (1)
Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells (2017) (1)
Local intracerebral Inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo (2020) (1)
PERK deficiency distorts the ER-mitochondrial interface and protects against ROS-induced intrinsic apoptosis (2010) (1)
G2/M Arrest Sensitizes Chronic Myelogenous Leukemia Cells to TRAIL-Induced Apoptosis (2010) (1)
miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts (2014) (1)
Unfolded protein response at the cross roads of tumourigenesis, oxygen sensing and drug resistance in clear cell renal cell carcinoma. (2022) (1)
Loss of Dicer1 in mouse embryonic fibroblasts impairs ER stress-induced apoptosis (2015) (1)
Maintenance of Endoplasmic Reticulum Protein Homeostasis in Cancer: Friend or Foe. (2021) (1)
Inhibition of IRE1α RNase activity sensitizes patient‐derived acute myeloid leukaemia cells to proteasome inhibitors (2022) (1)
Editorial: Cell stress and cell death (2010) (1)
Endoplasmic Reticulum Stress-Regulated Chaperones as a Serum Biomarker Panel for Parkinson’s Disease (2022) (1)
Constitutive IRE1α signaling maintains glioblastoma cell differentiation (2019) (0)
Title Bisphenol A-Mediated Suppression of LPL Gene Expression Inhibits Triglyceride Accumulation during Adipogenic Differentiation of Human Adult Stem Cells (2019) (0)
Structural distortions induced by Kinase Inhibiting RNase Attenuator (KIRA) compounds prevent the formation of face-to-face dimers of Inositol Requiring Enzyme 1α (2019) (0)
505 Dual Cdc7/Cdk9 kinase inhibitor, PHA-767491, targets both quiescent and proliferating CLL cells (2010) (0)
OS1.8 IRE1-mediated immunomodulation in glioblastoma. (2016) (0)
12 Cytokine-Induced-Cell Stress and Death in Type 1 Diabetes Mellitus (2012) (0)
DESIGNED RECEPTOR SPECIFIC RHTRAIL VARIANTS ENHANCE INDUCTION OF APOPTOSIS IN CANCER CELLS (2011) (0)
Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL (2019) (0)
Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML (2018) (0)
PERK is an essential component of the ER-to-mitochondria contact sites required to convey mitochondrial apoptosis following ROS-mediated ER stress (2011) (0)
PHA767491, a Dual Cdc7/CDK9 Inhibitor, with Potential to Target Both Proliferation and Survival in CLL. (2009) (0)
PERK is a component of the mitochondria-associated membranes that shapes ER-mitochondria interactions during ER stress (2013) (0)
Dual IRE1 RNase functions dictate glioblastoma development (2023) (0)
University of Groningen Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model Duiker, (2022) (0)
Title Methods for Monitoring Endoplasmic Reticulum Stress and theUnfolded Protein Response (2017) (0)
Abstracts of the Royal Academy of Medicine in Ireland Section of Biomedical Sciences Annual Meeting 2012. June 14, 2012. Galway, Ireland. (2013) (0)
Uncovering new roles of the endoplasmic reticulum stress kinase PERK beyond the unfolded protein response (2014) (0)
Heat shock proteins protect PC12 cells from MPP+ toxicity (2002) (0)
Correction: Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells (2018) (0)
Dual IRE1 RNase functions dictate glioblastoma development (2022) (0)
Decorated macrocycles via ring-closing double-reductive amination. Identification of an apoptosis inducer of leukemic cells that antagonizes a 5-HT2 via Ring-Closing Double-Reductive Amination. (2018) (0)
Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors (2019) (0)
The eIF2α kinases: their structures and functions (2013) (0)
Royal academy of medicine in Ireland (0)
550. Adenoviral-Mediated Antioxidant Overexpression: Possible Protective Role Against Hyperglycemic Conditions in Human Aortic Endothelial Cells (2005) (0)
Cytokine design: US Patent 7,994,281 (2011) (0)
Trail variants for treating cancer: World Patent WO/2009/077,857 (2009) (0)
Improved cytokine design: European Patent 2,224,944 (2010) (0)
New insights into IRE1α activation and function in anti-tumor immunity (2022) (0)
Correction: Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β (2020) (0)
Correction: Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β (2020) (0)
IMPROVED TUMOR CELL KILLING BY TRAIL REQUIRES SELECTIVE AND HIGH AFFINITY RECEPTOR ACTIVATION (2011) (0)
Cytokine design: US patent App. 12/744,069 (2008) (0)
COMPUTATIONAL DESIGN OF RECEPTOR SELECTIVE TRAIL VARIANTS (2011) (0)
Application of a New Multiplexed Array for Rapid, Sensitive, Simultaneous and Quantitative Assessment of Spliced and Unspliced XBP1 (2019) (0)
The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors (2019) (0)
Role of antioxidants in the regulation of stress response (1998) (0)
Preclinical Combination of a Novel Ire1 Rnase Inhibitor Mkc-8866 and Tyrosine Kinase Inhibition Acts Synergistic in Acute Lymphoblastic Leukemia (2017) (0)
Regulation of Apoptosis by Heat Shock Proteins Donna Kennedy 1 (2014) (0)
Using omics approaches to develop a biomarker signature for anti-psychotic drug toxicity (2018) (0)
Conception de cytokine améliorée (2008) (0)
PERK deficiency protects against ROS-mediated cell death by impairing the induction of pro-apoptotic UPR target genes (2009) (0)
ENHANCED ANTI-TUMOR EFFICACY OF A DR5-SPECIFIC TRAIL VARIANT OVER RHTRAIL IN A BIOLUMINESCENT OVARIAN CANCER XENOGRAFT MODEL (2011) (0)

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