Akane Kawamura

Q: What Schools Are Affiliated With Akane Kawamura

Akane Kawamura is affiliated with the following schools: Imperial College London, University of Oxford, Newcastle University

Akane Kawamura's AcademicInfluence.com Rankings

Akane Kawamura

Chemistry

#5780

World Rank

#7008

Historical Rank

Organic Chemistry

#1065

World Rank

#1203

Historical Rank

chemistry Degrees

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Chemistry

Akane Kawamura's Degrees

Masters Chemistry University of Oxford
Bachelors Chemistry University of Oxford

Why Is Akane Kawamura Influential?

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According to Wikipedia, Akane Kawamura is a British chemist who is professor of chemistry at Newcastle University. Her research considers the chemistry of epigenetics. She was awarded the Royal Society of Chemistry Jeremy Knowles Award for her development of chemical probes to study biological processes.

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Akane Kawamura's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases (2011) (851)
Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors (2010) (198)
Inhibition of 2-oxoglutarate dependent oxygenases. (2011) (191)
Targeting histone lysine demethylases — Progress, challenges, and the future (2014) (167)
Inhibition of 2‐Oxoglutarate Dependent Oxygenases (2011) (162)
Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases (2016) (160)
Recent Progress in Histone Demethylase Inhibitors. (2016) (152)
Arylamine N-acetyltransferases: structural and functional implications of polymorphisms. (2008) (131)
5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. (2013) (131)
Epigenetic regulation by histone demethylases in hypoxia. (2015) (111)
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. (2012) (109)
Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. (2013) (104)
Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition. (2014) (103)
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. (2014) (102)
Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening. (2005) (99)
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides (2017) (97)
The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid. (2002) (89)
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells (2017) (81)
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors (2016) (78)
Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases (2014) (78)
Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2. (2009) (71)
Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. (2012) (68)
Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity (2013) (65)
Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates (2014) (65)
The pharmacogenetics of NAT: structural aspects. (2002) (63)
Development of homogeneous luminescence assays for histone demethylase catalysis and binding. (2010) (62)
The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations (2017) (57)
A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1 (2014) (55)
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors. (2013) (48)
Structure and mechanism of arylamine N-acetyltransferases. (2006) (48)
A photoreactive small-molecule probe for 2-oxoglutarate oxygenases. (2011) (47)
Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars (2010) (45)
Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker. (2010) (42)
Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1 (2008) (41)
Light-driven post-translational installation of reactive protein side chains (2020) (40)
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain (2015) (39)
Synthesis and anticancer activities of 6-amino amonafide derivatives (2008) (39)
Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis. (2009) (39)
Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity (2013) (35)
Assessing histone demethylase inhibitors in cells: lessons learned (2017) (33)
Is JmjC Oxygenase Catalysis Limited to Demethylation?** (2013) (31)
Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases. (2015) (29)
KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability (2017) (28)
Piperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside Macrophages (2012) (28)
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor† (2014) (27)
KDM4A regulates HIF-1 levels through H3K9me3 (2017) (26)
Discovery of a Highly Selective Cell‐Active Inhibitor of the Histone Lysine Demethylases KDM2/7 (2017) (24)
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities (2017) (22)
Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates (2017) (22)
Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition. (2017) (22)
Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system (2008) (21)
Over-expression, Purification, and Characterization of Recombinant Human Arylamine N-Acetyltransferase 1 (2005) (21)
Description of a novel polymorphic gene encoding for arylamine N-acetyltransferase in the rhesus macaque (Macaca mulatta), a model animal for endometriosis (2007) (20)
Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer (2019) (20)
2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2† †Electronic supplementary information (ESI) available: Details of experimental procedures and additional experiments. See DOI: 10.1039/c8cc00387d (2018) (20)
Comparison of the Arylamine N-Acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis (2009) (19)
The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases. (2019) (18)
Novel small-molecule inhibitors of arylamine N-acetyltransferases: drug discovery by high-throughput screening. (2011) (17)
Modulating carnitine levels by targeting its biosynthesis – selective inhibition of γ-butyrobetaine hydroxylase (2014) (17)
Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion. (2013) (17)
Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases (2018) (17)
A knottin scaffold directs the CXC-chemokine–binding specificity of tick evasins (2019) (16)
The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins (2018) (15)
Tetracyanoresorcin[4]arene selectively recognises trimethyllysine and inhibits its enzyme-catalysed demethylation (2016) (15)
Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases (2018) (15)
Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A. (2018) (14)
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors (2018) (14)
JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer (2021) (12)
Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase. (2003) (12)
Enhancement of retroviral gene transduction on a dish coated with a cocktail of two different polypeptides: one exhibiting binding activity toward target cells, and the other toward retroviral vectors. (1998) (11)
Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications (2020) (10)
Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets (2018) (10)
Non-competitive cyclic peptides for targeting enzyme–substrate complexes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00286j (2018) (10)
Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding (2014) (9)
Synthesis and Biological Evaluation of Tripartin, a Putative KDM4 Natural Product Inhibitor, and 1‐Dichloromethylinden‐1‐ol Analogues (2018) (9)
Mechanistic and structural studies of KDM‐catalysed demethylation of histone 1 isotype 4 at lysine 26 (2018) (8)
Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity (2018) (8)
Using evasins to target the chemokine network in inflammation. (2020) (7)
Lysine‐241 Has a Role in Coupling 2OG Turnover with Substrate Oxidation During KDM4‐Catalysed Histone Demethylation (2018) (6)
Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor. (2017) (6)
Engineered anti-inflammatory peptides inspired by mapping an evasin–chemokine interaction (2020) (5)
Formaldehyde quantification using ampicillin is not selective (2019) (5)
Structural diversity in de novo cyclic peptide ligands from genetically encoded library technologies (2020) (4)
JmjC-domain-Containing Histone Demethylases (2019) (3)
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53 (2021) (3)
In Vitro Enzyme Assays for JmjC‐Domain‐Containing Lysine Histone Demethylases (JmjC‐KDMs) (2018) (3)
Dual LSD1 and HDAC6 Inhibition Induces Doxorubicin Sensitivity in Acute Myeloid Leukemia Cells (2022) (2)
Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of γ-butyrobetaine hydroxylase. (2014) (2)
Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2 (2020) (2)
Abstract: Neuroendocrine expression of mouse arylamine N-acetyltransferase 2 (2006) (1)
Polymorphism of Mycobacterial Arylamine N-acetyltransferases may Lead to Structural Change (2000) (1)
An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor (2022) (1)
Metampicillin is a cyclic aminal produced by reaction of ampicillin with formaldehyde (2020) (1)
Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding (2014) (1)
Mutations to metabolic enzymes in cancer herald a need to unify genetics and biochemistry (2011) (1)
Human histone demethylase KDM6B can catalyse sequential oxidations† †Electronic supplementary information (ESI) available: Procedures for synthesis of lysine analogues, solid phase peptide synthesis, MS and NMR activity assays. Characterisation of lysine analogues. See DOI: 10.1039/c8cc04057e (2018) (1)
Chemical Compounds Targeting DNA Methylation and Hydroxymethylation (2019) (1)
JmjC ‐domain‐Containing Histone Demethylases (2019) (1)
Figure 16, Probe development/medicinal chemistry optimization flowchart (2013) (0)
Figure 6, Plate Z' trend for the JMJD2E primary qHTS (2013) (0)
KDM4A regulates HIF-1 levels through H3K9me3 (2017) (0)
Scheme 1, Synthetic route for analogs containing 5-COOH (2013) (0)
Figure 18, Co-crystallization of compound 1 with JMJD2A (PDB: 3NJY) (2013) (0)
The catalytic domains of all human KDM5 JmjC demethylases catalyse N‐methyl arginine demethylation (2023) (0)
Chapter 8 Inhibitors of JmjC-containing Histone Demethylases (2020) (0)
Figure 13, Immunofluorescent staining for the HSV DNA replication protein UL29 (2013) (0)
Editorial overview: Epigenetics equals chemical biology. (2020) (0)
Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function (2023) (0)
JMJD2A/ KDM4A COMPLEXED WITH NI(II) AND Macrocyclic PEPTIDE Inhibitor CP2 (13-mer) (2017) (0)
M. smegmatis arylamine N-acetyl transferase (2002) (0)
Structure of arylamrae-N-acetyl transferases (2000) (0)
Corrigendum to “Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A” (Bioorganic & Medicinal Chemistry (2018) 26(6) (1225–1231), (S0968089617318497) (10.1016/j.bmc.2018.01.013)) (2019) (0)
Figure 11, [(A) Viral IE (ICP4, ICP27,...]. (2013) (0)
Figure 17, SAR summary of JMD2E probe, ML324 (2013) (0)
Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets (2018) (0)
Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins. (2022) (0)
Author Correction: Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities (2021) (0)
Increasing Diversity in Admissions to Postgraduate Study. (2022) (0)
Author Correction: Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities (2017) (0)
Figure 15, MRC-5 cells were treated with DMSO or 50 mM ML324 for 3 hr, followed by infection with hCMV (0.1 pfu/cell) for 5 hr (2013) (0)
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH DAMINOZIDE (2012) (0)
Figure 12, [(A) MRC-5 cells were treated...]. (2013) (0)
triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM 2 A ( FBXL 11 ) inhibitor † (2014) (0)
8-Hydroxyquinoline-5-Carboxylic Acid is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation (2013) (0)
Crystal Structure of the Covalent Adduct Formed between Mycobacterium marinum Aryalamine N-acetyltransferase and Phenyl vinyl ketone a derivative of Piperidinols (2013) (0)
The influence of degree of labelling upon cellular internalisation of antibody-cell penetrating peptide conjugates (2022) (0)
Figure 14, [(A) Viral yields from HSV-1...]. (2013) (0)
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials † EDGE (2017) (0)
Table 1, LSD1 histone demethylaseassay protocol (2013) (0)
Table 4, ADME profile for ML324 (2013) (0)
Assessing histone demethylase inhibitors in cells: lessons learned (2017) (0)
[Table, MLS Numbers for probe analogs]. (2013) (0)
Inhibitors of JmjC-Containing Histone Demethylases (2019) (0)
P58Towards understanding the effect of ischaemia on epigenetic regulation by the histone demethylases (2014) (0)
Figure 8, Concentration response curve of compound 1 (CID: 459617) in MALDI-TOF-MS hit validation assay (2013) (0)
Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins (2022) (0)
Figure 1, Previously reported inhibitors of JMJD histone demethylases (2013) (0)
Table 3, Variations to compound 1 (2013) (0)
Corrigendum to "Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A" [Bioorg. Med. Chem. 26/6 (2018) 1225-1231]. (2019) (0)
Crystal Structure of human PHF8 in complex with Daminozide (2012) (0)

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What Schools Are Affiliated With Akane Kawamura?

Akane Kawamura is affiliated with the following schools:

Akane Kawamura's Academic­Influence.com Rankings