Akihiko Yoshimura
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Computer Science
Akihiko Yoshimura's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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(Suggest an Edit or Addition)Akihiko Yoshimura's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A new protein containing an SH2 domain that inhibits JAK kinases (1997) (1497)
- SOCS proteins, cytokine signalling and immune regulation (2007) (1489)
- Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system (2006) (996)
- Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses (2010) (872)
- Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury (2006) (837)
- IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages (2003) (797)
- Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. (2009) (792)
- The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop (1999) (785)
- Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. (2011) (757)
- Regulation of cytokine signaling and inflammation. (2002) (694)
- Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. (2006) (672)
- Suppressors of cytokine signaling and immunity (2003) (664)
- Negative regulation of cytokine signaling pathways. (2000) (636)
- Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity (2004) (617)
- SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality (1999) (572)
- CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. (1997) (567)
- Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3. (2004) (554)
- SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. (2002) (550)
- A gp130–Src–YAP module links inflammation to epithelial regeneration (2015) (483)
- Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury (2009) (472)
- Cytokine‐inducible SH2 protein‐3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N‐terminal kinase inhibitory region as well as SH2 domain (1999) (433)
- Spred is a Sprouty-related suppressor of Ras signalling (2001) (428)
- 1,25-Dihydroxyvitamin D3 Ameliorates Th17 Autoimmunity via Transcriptional Modulation of Interleukin-17A (2011) (405)
- Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis (2009) (403)
- Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1–like phenotype (2007) (398)
- Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. (2001) (398)
- SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis (1999) (391)
- Cis3/Socs3/Ssi3 Plays a Negative Regulatory Role in Stat3 Activation and Intestinal Inflammation (2001) (387)
- Foxp3 Inhibits RORγt-mediated IL-17A mRNA Transcription through Direct Interaction with RORγt*♦ (2008) (383)
- Nr4a transcription factors limit CAR T cell function in solid tumors (2019) (379)
- SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses (2003) (379)
- Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain (2012) (366)
- Single-molecule imaging analysis of Ras activation in living cells. (2004) (358)
- Structure, function, and activation of the erythropoietin receptor. (1993) (355)
- Angiogenic factor (1992) (354)
- CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2* (2000) (349)
- Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7* (1999) (345)
- Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery (2019) (335)
- The Jak-Stat pathway in normal and perturbed hematopoiesis. (2000) (335)
- The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2* (2001) (324)
- Induction of Keratinocyte Migration via Transactivation of the Epidermal Growth Factor Receptor by the Antimicrobial Peptide LL-371 (2005) (324)
- Cellular and molecular basis for the regulation of inflammation by TGF-beta. (2010) (316)
- WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. (2003) (300)
- Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity (1990) (297)
- Signal transduction of inflammatory cytokines and tumor development (2006) (296)
- Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: regulation of T-cell inflammation by SOCS1 and SOCS3. (2011) (296)
- Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment1 (2003) (290)
- Homodimerization and constitutive activation of the erythropoietin receptor. (1992) (289)
- Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice (1999) (280)
- SOCS-3 Is Tyrosine Phosphorylated in Response to Interleukin-2 and Suppresses STAT5 Phosphorylation and Lymphocyte Proliferation (1999) (280)
- Involvement of Suppressor of Cytokine Signaling-3 as a Mediator of the Inhibitory Effects of IL-10 on Lipopolysaccharide-Induced Macrophage Activation1 (2002) (278)
- Cloning and characterization of novel CIS family genes. (1997) (276)
- The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains (1991) (276)
- Smad2 and Smad3 Are Redundantly Essential for the TGF-β–Mediated Regulation of Regulatory T Plasticity and Th1 Development (2010) (269)
- Membrane molecules mobile even after chemical fixation (2010) (267)
- Angiogenesis induced by advanced glycation end products and its prevention by cerivastatin (2002) (262)
- IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis. (2011) (257)
- Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis (2013) (256)
- SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130* (2003) (256)
- Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. (2003) (252)
- Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation (2002) (248)
- Induced Regulatory T Cells: Their Development, Stability, and Applications. (2016) (246)
- Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor–β1 (2006) (241)
- Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β (2004) (238)
- Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK‐STAT5 pathway. (1996) (236)
- Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. (2006) (233)
- Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation (2002) (228)
- IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. (2013) (228)
- Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation. (1999) (226)
- Src-catalyzed Phosphorylation of c-Cbl Leads to the Interdependent Ubiquitination of Both Proteins* (2001) (225)
- A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice. (2013) (222)
- SOCS, Inflammation, and Autoimmunity (2011) (221)
- Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury (2015) (217)
- Target cell defense prevents the development of diabetes after viral infection (2002) (213)
- Proteasomes Regulate Erythropoietin Receptor and Signal Transducer and Activator of Transcription 5 (STAT5) Activation (1998) (207)
- Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism. (1990) (207)
- CLP1 links tRNA metabolism to progressive motor-neuron loss (2013) (206)
- Control mechanism of JAK/STAT signal transduction pathway (2003) (203)
- Pigment Epithelium-derived Factor Inhibits Advanced Glycation End Product-induced Retinal Vascular Hyperpermeability by Blocking Reactive Oxygen Species-mediated Vascular Endothelial Growth Factor Expression* (2006) (201)
- A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons. (1998) (199)
- Identification of a Dominant Negative Mutant of Sprouty That Potentiates Fibroblast Growth Factor- but Not Epidermal Growth Factor-induced ERK Activation* (2001) (195)
- Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis. (2006) (194)
- Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis (2019) (194)
- IFNγ-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice (2006) (189)
- Two-Sided Roles of IL-27: Induction of Th1 Differentiation on Naive CD4+ T Cells versus Suppression of Proinflammatory Cytokine Production Including IL-23-Induced IL-17 on Activated CD4+ T Cells Partially Through STAT3-Dependent Mechanism1 (2006) (188)
- Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis. (2009) (180)
- SOCS1 Is a Suppressor of Liver Fibrosis and Hepatitis-induced Carcinogenesis (2004) (177)
- Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1 (2003) (177)
- Post-Ischemic Inflammation in the Brain (2012) (173)
- The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells (2011) (170)
- Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways. (2001) (169)
- SOCS, inflammation, and cancer (2013) (166)
- SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production (2011) (164)
- TGF-β function in immune suppression. (2010) (163)
- Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-γ on STAT3 and Smads1 (2008) (163)
- Negative regulation of cytokine signaling and immune responses by SOCS proteins (2005) (159)
- STAT6 Inhibits TGF-β1-mediated Foxp3 Induction through Direct Binding to the Foxp3 Promoter, Which Is Reverted by Retinoic Acid Receptor* (2008) (158)
- Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors (2006) (156)
- Interaction between Ebola Virus Glycoprotein and Host Toll-Like Receptor 4 Leads to Induction of Proinflammatory Cytokines and SOCS1 (2009) (152)
- Post-ischemic inflammation regulates neural damage and protection (2014) (152)
- The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential. (2009) (150)
- The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation* (2014) (146)
- Brief Report: Number of Circulating Follicular Helper 2 T Cells Correlates With IgG4 and Interleukin‐4 Levels and Plasmablast Numbers in IgG4‐Related Disease (2015) (145)
- Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein. (2009) (141)
- Clinical relevance of circulating cell-free microRNAs in ovarian cancer (2016) (140)
- Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia (2005) (139)
- Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke (2012) (138)
- ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1 (2006) (138)
- MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1 (2017) (135)
- Mucosal T Cells Bearing TCRγδ Play a Protective Role in Intestinal Inflammation1 (2004) (135)
- Clinical and mutational spectrum of neurofibromatosis type 1-like syndrome. (2009) (135)
- JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling. (2001) (133)
- ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells (2014) (132)
- Exacerbation of Experimental Allergic Asthma by Augmented Th2 Responses in WSX-1-Deficient Mice1 (2005) (131)
- Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation (1997) (129)
- Spreds Are Essential for Embryonic Lymphangiogenesis by Regulating Vascular Endothelial Growth Factor Receptor 3 Signaling (2007) (129)
- Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesodermin. (2011) (128)
- Negative regulation of cytokine signaling influences inflammation. (2003) (128)
- Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells. (2015) (127)
- Mammalian Sprouty4 Suppresses Ras-Independent ERK Activation by Binding to Raf1 (2003) (125)
- Role of the JAK/STAT pathway in rat carotid artery remodeling after vascular injury. (2000) (121)
- Potentiation of Astrogliogenesis by STAT3-Mediated Activation of Bone Morphogenetic Protein-Smad Signaling in Neural Stem Cells (2007) (118)
- The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. (2003) (118)
- Enhanced IgG4 production by follicular helper 2 T cells and the involvement of follicular helper 1 T cells in the pathogenesis of IgG4-related disease (2016) (117)
- Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness (2005) (117)
- The B cell‐specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction (2003) (116)
- Pigment epithelium-derived factor inhibits TNF-α-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation (2004) (116)
- CIS Associates with the Interleukin-2 Receptor β Chain and Inhibits Interleukin-2-dependent Signaling* (1999) (115)
- Deleterious Effect of the IL-23/IL-17A Axis and γδT Cells on Left Ventricular Remodeling After Myocardial Infarction (2012) (115)
- Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. (2003) (114)
- Divergent Mechanisms Utilized by SOCS3 to Mediate Interleukin-10 Inhibition of Tumor Necrosis Factor α and Nitric Oxide Production by Macrophages* (2006) (109)
- Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells. (2017) (109)
- In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130 (1992) (108)
- Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. (2004) (108)
- Induction of Hyper Th1 Cell-Type Immune Responses by Dendritic Cells Lacking the Suppressor of Cytokine Signaling-1 Gene1 (2005) (108)
- Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance (2011) (108)
- Negative regulation of cytokine and TLR signalings by SOCS and others. (2005) (108)
- Reciprocal Regulation of SOCS 1 and SOCS3 Enhances Resistance to Ionizing Radiation in Glioblastoma Multiforme (2007) (107)
- Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis (2008) (106)
- The N-terminal Truncated Isoform of SOCS3 Translated from an Alternative Initiation AUG Codon under Stress Conditions Is Stable Due to the Lack of a Major Ubiquitination Site, Lys-6* (2003) (105)
- Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor. (1992) (104)
- Negative Regulation of Cytokine Signaling in Immunity. (2018) (103)
- Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission (2018) (103)
- SOCS3 Is a Physiological Negative Regulator for Granulopoiesis and Granulocyte Colony-stimulating Factor Receptor Signaling* (2004) (101)
- Hyperproduction of Proinflammatory Cytokines by WSX-1-Deficient NKT Cells in Concanavalin A-Induced Hepatitis1 (2004) (101)
- Regulation of cytokine signaling by the SOCS and Spred family proteins. (2009) (101)
- Loss of SOCS3 Gene Expression Converts STAT3 Function from Anti-apoptotic to Pro-apoptotic* (2006) (99)
- Spred1 Is Required for Synaptic Plasticity and Hippocampus-Dependent Learning (2008) (99)
- Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling. (2007) (98)
- A Role of Suppressor of Cytokine Signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated Interleukin 2 Production (2003) (97)
- Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. (2008) (96)
- Exosomes Promote Ovarian Cancer Cell Invasion through Transfer of CD44 to Peritoneal Mesothelial Cells (2016) (96)
- Control of α Subunit of Eukaryotic Translation Initiation Factor 2 (eIF2α) Phosphorylation by the Human Papillomavirus Type 18 E6 Oncoprotein: Implications for eIF2α-Dependent Gene Expression and Cell Death (2004) (95)
- CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells (1998) (95)
- The dual function of hepatic SOCS3 in insulin resistance in vivo (2007) (93)
- The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization (2004) (93)
- TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway* (2008) (90)
- Spred-1 Negatively Regulates Interleukin-3-mediated ERK/Mitogen-activated Protein (MAP) Kinase Activation in Hematopoietic Cells* (2004) (90)
- Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation. (2004) (88)
- Memory T cell, exhaustion, and tumor immunity (2019) (87)
- APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis (1999) (87)
- Analysis of SOCS-3 Promoter Responses to Interferon γ* (2004) (86)
- IL-23–Independent Induction of IL-17 from γδT Cells and Innate Lymphoid Cells Promotes Experimental Intraocular Neovascularization (2013) (83)
- FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging. (2008) (83)
- Modulation of TLR4 Signaling by a Novel Adaptor Protein Signal-Transducing Adaptor Protein-2 in Macrophages1 (2006) (83)
- A Mutant Form of JAB/SOCS1 Augments the Cytokine-induced JAK/STAT Pathway by Accelerating Degradation of Wild-type JAB/CIS Family Proteins through the SOCS-box* (2001) (82)
- Raftlin Is Involved in the Nucleocapture Complex to Induce Poly(I:C)-mediated TLR3 Activation* (2011) (81)
- SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag (2008) (81)
- Cytokine‐inducible SH2 protein (CIS3) and JAK2 binding protein (JAB) abolish prolactin receptor‐mediated STAT5 signaling (1998) (80)
- The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells (2005) (80)
- The liver–brain–gut neural arc maintains the Treg cell niche in the gut (2020) (80)
- Ligand-induced activation of chimeric receptors between the erythropoietin receptor and receptor tyrosine kinases. (1994) (79)
- Model analysis of difference between EGF pathway and FGF pathway. (2004) (79)
- Exosomal miR-99a-5p is elevated in sera of ovarian cancer patients and promotes cancer cell invasion by increasing fibronectin and vitronectin expression in neighboring peritoneal mesothelial cells (2018) (78)
- Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved. (2006) (78)
- Selective Expansion of Foxp3-Positive Regulatory T Cells and Immunosuppression by Suppressors of Cytokine Signaling 3-Deficient Dendritic Cells1 (2007) (78)
- Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells (2017) (77)
- Innate Defense Mechanism Against Virus Infection Within the Cardiac Myocyte Requiring gp130-STAT3 Signaling (2006) (77)
- Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy (2017) (77)
- The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling. (2004) (75)
- The CIS family: negative regulators of JAK-STAT signaling. (1998) (73)
- Roles of STAT3/SOCS3 Pathway in Regulating the Visual Function and Ubiquitin-Proteasome-dependent Degradation of Rhodopsin during Retinal Inflammation* (2008) (71)
- Minodronate, a newly developed nitrogen-containing bisphosphonate, suppresses melanoma growth and improves survival in nude mice by blocking vascular endothelial growth factor signaling. (2004) (71)
- 25-Dihydroxyvitamin D 3 Ameliorates Th 17 Autoimmunity via Transcriptional Modulation of Interleukin-17 A (2011) (71)
- Therapeutic effect of IL-12/23 and their signaling pathway blockade on brain ischemia model. (2010) (70)
- Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice. (2011) (70)
- Peptidoglycan and lipopolysaccharide activate PLCγ2, leading to enhanced cytokine production in macrophages and dendritic cells (2008) (70)
- Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain. (1998) (70)
- SH2-B Is Required for Both Male and Female Reproduction (2002) (70)
- Spred-2 Suppresses Aorta-Gonad-Mesonephros Hematopoiesis by Inhibiting MAP Kinase Activation (2004) (68)
- Differential roles for IFN-gamma and IL-17 in experimental autoimmune uveoretinitis. (2008) (68)
- STAP-2/BKS, an Adaptor/Docking Protein, Modulates STAT3 Activation in Acute-phase Response through Its YXXQ Motif* (2003) (68)
- APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl (1999) (67)
- SOCS‐1 can suppress CD3ζ‐ and Syk‐mediated NF‐AT activation in a non‐lymphoid cell line (2000) (67)
- Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice. (2008) (67)
- SOCS1-negative feedback of STAT1 activation is a key pathway in the dsRNA-induced innate immune response of human keratinocytes. (2006) (67)
- Physiology and function of the erythropoietin receptor (1998) (66)
- Regulation of TLR signaling and inflammation by SOCS family proteins (2004) (66)
- Smad2/3 and IRF4 Play a Cooperative Role in IL-9–Producing T Cell Induction (2013) (65)
- Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy (2017) (64)
- High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells (2016) (63)
- Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation (2009) (63)
- Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice (2014) (62)
- Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction. (2011) (61)
- Silencing Suppressor of Cytokine Signaling-1 (SOCS1) in Macrophages Improves Mycobacterium tuberculosis Control in an Interferon-γ (IFN-γ)-dependent Manner* (2011) (61)
- FLN29, a Novel Interferon- and LPS-inducible Gene Acting as a Negative Regulator of Toll-like Receptor Signaling* (2005) (60)
- FLN29 Deficiency Reveals Its Negative Regulatory Role in the Toll-like Receptor (TLR) and Retinoic Acid-inducible Gene I (RIG-I)-like Helicase Signaling Pathway* (2008) (60)
- SOC1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein (2004) (60)
- Combined hypermethylation and chromosome loss associated with inactivation of SSI-1/SOCS-1/JAB gene in human hepatocellular carcinomas. (2002) (60)
- Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1. (1999) (59)
- Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor α (WSX-1) (2007) (59)
- A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. (2006) (58)
- Stat5a Inhibits IL-12-Induced Th1 Cell Differentiation through the Induction of Suppressor of Cytokine Signaling 3 Expression1 (2005) (58)
- Aryl hydrocarbon receptor protects against bacterial infection by promoting macrophage survival and reactive oxygen species production. (2014) (58)
- miR126 positively regulates mast cell proliferation and cytokine production through suppressing Spred1 (2011) (58)
- Molecular cloning and functional characterization of a novel member of the C-C chemokine family. (1995) (58)
- Suppressor of cytokine signaling 1 protects mice against concanavalin A–induced hepatitis by inhibiting apoptosis (2008) (58)
- The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit. (2003) (58)
- Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren’s syndrome (2017) (57)
- TRAF6 Is Essential for Maintenance of Regulatory T Cells That Suppress Th2 Type Autoimmunity (2013) (57)
- A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins. (1999) (57)
- Exosomal miR-1290 is a potential biomarker of high-grade serous ovarian carcinoma and can discriminate patients from those with malignancies of other histological types (2018) (57)
- SOCS3 negatively regulates the gp130-STAT3 pathway in mouse skin wound healing. (2008) (57)
- Critical Link Between Epigenetics and Transcription Factors in the Induction of Autoimmunity: a Comprehensive Review (2016) (56)
- Increased expression of TLR2 in CD4+ T cells from SLE patients enhances immune reactivity and promotes IL‐17 expression through histone modifications (2015) (56)
- Loss of Pdk1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance (2012) (56)
- TGF‐β1 suppresses IFN‐γ‐induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation (2006) (55)
- TRAF6 Is Required for Generation of the B-1a B Cell Compartment as well as T Cell-Dependent and -Independent Humoral Immune Responses (2009) (55)
- CCL2-induced migration and SOCS3-mediated activation of macrophages are involved in cerulein-induced pancreatitis in mice. (2012) (55)
- The CIS/JAB family: novel negative regulators of JAK signaling pathways (1998) (55)
- STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression (2004) (55)
- Inhibition of STAT3 prevents neointima formation by inhibiting proliferation and promoting apoptosis of neointimal smooth muscle cells. (2003) (55)
- SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. (2007) (54)
- Physical and Functional Interactions between STAP-2/BKS and STAT5* (2005) (54)
- Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation (2017) (54)
- Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling (2017) (52)
- Regulation and function of the cytokine-inducible SH-2 domain proteins, CIS and SOCS3, in mammary epithelial cells. (2002) (52)
- Induction and maintenance of regulatory T cells by transcription factors and epigenetic modifications. (2017) (52)
- Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1*♦ (2015) (52)
- Strand and Cell Type-specific Function of microRNA-126 in Angiogenesis. (2016) (51)
- STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation. (2009) (51)
- Gfi1 negatively regulates T(h)17 differentiation by inhibiting RORgammat activity. (2009) (50)
- Proliferation and erythroid differentiation through the cytoplasmic domain of the erythropoietin receptor. (1994) (50)
- Signal-Transducing Adaptor Protein-2 Regulates Integrin-Mediated T Cell Adhesion through Protein Degradation of Focal Adhesion Kinase1 (2007) (49)
- The neuropeptide neuromedin U promotes IL-6 production from macrophages and endotoxin shock. (2006) (49)
- Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells (2015) (49)
- Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells. (2011) (48)
- The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia. (2006) (48)
- The Sprouty‐related protein, Spred‐1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin‐1 (2005) (47)
- Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases. (2003) (47)
- Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation. (2012) (46)
- Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling. (2011) (46)
- Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 Is Involved in gp130 Resistance in Cardiovascular System in Rat Treated With Cardiotrophin-1 In Vivo (2001) (46)
- Smad2/3 Proteins Are Required for Immobilization-induced Skeletal Muscle Atrophy* (2016) (46)
- Pyridone 6, a Pan-JAK Inhibitor, Ameliorates Allergic Skin Inflammation of NC/Nga Mice via Suppression of Th2 and Enhancement of Th17 (2011) (46)
- Biocompatible fluorescent silicon nanocrystals for single-molecule tracking and fluorescence imaging (2013) (46)
- Suppression of Sproutys Has a Therapeutic Effect for a Mouse Model of Ischemia by Enhancing Angiogenesis (2009) (45)
- Incadronate disodium inhibits advanced glycation end products-induced angiogenesis in vitro. (2002) (45)
- Pigment epithelium-derived factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation. (2004) (44)
- Legius Syndrome in Fourteen Families (2011) (44)
- An RNA-binding protein αCP-1 is involved in the STAT3-mediated suppression of NF-κB transcriptional activity (2007) (43)
- SOCS3 in T and NKT Cells Negatively Regulates Cytokine Production and Ameliorates ConA-Induced Hepatitis1 (2009) (43)
- Generation of allo-antigen-specific induced Treg stabilized by vitamin C treatment and its application for prevention of acute graft versus host disease model (2017) (42)
- Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains. (2000) (42)
- Suppressors of Cytokine Signaling-1 and -3 Regulate Osteoclastogenesis in the Presence of Inflammatory Cytokines1 (2005) (42)
- The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK–STAT activation (2000) (41)
- Interactions of STAP-2 with Brk and STAT3 Participate in Cell Growth of Human Breast Cancer Cells* (2010) (41)
- Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells. (2008) (41)
- JAK's SOCS: a mechanism of inhibition. (2012) (41)
- Suppression of IL-6 production and proliferation by blocking STAT3 activation in malignant soft tissue tumor cells. (2006) (41)
- Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression. (2019) (40)
- Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes. (2005) (40)
- Sprouty4 deficiency potentiates Ras‐independent angiogenic signals and tumor growth (2009) (40)
- Inhibition of Nr4a Receptors Enhances Antitumor Immunity by Breaking Treg-Mediated Immune Tolerance. (2018) (40)
- TGFβ-induced epigenetic deregulation of SOCS3 facilitates STAT3-signaling to promote fibrosis. (2020) (40)
- Dysregulation of Suppressor of Cytokine Signaling 3 in Keratinocytes Causes Skin Inflammation Mediated by Interleukin-20 Receptor-Related Cytokines (2012) (40)
- Interleukin-10 and cAMP-elevating agents cooperate to induce suppressor of cytokine signaling-3 via a protein kinase A-independent signal. (2002) (40)
- Negative regulation of cytokine signaling and inflammatory diseases. (2003) (40)
- Identification of definitive serum biomarkers associated with disease activity in primary Sjögren’s syndrome (2016) (39)
- SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage. (2008) (39)
- A Major Lipid Raft Protein Raftlin Modulates T Cell Receptor Signaling and Enhances Th17-Mediated Autoimmune Responses1 (2009) (39)
- Multi-dimensional analysis identified rheumatoid arthritis-driving pathway in human T cell (2019) (39)
- Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death. (2004) (39)
- In Vitro Th Differentiation Protocol. (2016) (38)
- Histone 3 Lysine 9 (H3K9) Methyltransferase Recruitment to the Interleukin-2 (IL-2) Promoter Is a Mechanism of Suppression of IL-2 Transcription by the Transforming Growth Factor-β-Smad Pathway* (2011) (38)
- Overexpression of SOCS3 in T Lymphocytes Leads to Impaired Interleukin-17 Production and Severe Aortic Aneurysm Formation in Mice—Brief Report (2013) (38)
- High-mobility group box 1 is an important mediator of microglial activation induced by cortical spreading depression (2017) (38)
- Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways. (2012) (38)
- Interaction and Functional Interference of Glucocorticoid Receptor and SOCS1* (2008) (38)
- Critical and Independent Role for SOCS3 in Either Myeloid or T Cells in Resistance to Mycobacterium tuberculosis (2013) (37)
- The Apoptotic Protease-Activating Factor 1-Mediated Pathway of Apoptosis Is Dispensable for Negative Selection of Thymocytes1 (2002) (37)
- Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway. (1999) (36)
- The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells. (2019) (36)
- CIS1 interacts with the Y532 of the prolactin receptor and suppresses prolactin-dependent STAT5 activation. (2003) (36)
- Adiponectin Enhances Antibacterial Activity of Hematopoietic Cells by Suppressing Bone Marrow Inflammation. (2016) (36)
- STAP-2 Negatively Regulates both Canonical and Noncanonical NF-κB Activation Induced by Epstein-Barr Virus-Derived Latent Membrane Protein 1 (2008) (35)
- PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts. (2009) (35)
- Development of experimental cerebral malaria is independent of IL-23 and IL-17. (2010) (35)
- Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice (2005) (35)
- Adaptor protein SH2-B linking receptor-tyrosine kinase and Akt promotes adipocyte differentiation by regulating peroxisome proliferator-activated receptor gamma messenger ribonucleic acid levels. (2007) (34)
- Insulin-like Growth Factor-I Augments Erythropoietin-induced Proliferation through Enhanced Tyrosine Phosphorylation of STAT5* (1998) (33)
- Herpes simplex virus hepatitis in macrophage-depleted mice: the role of massive, apoptotic cell death in pathogenesis. (1998) (33)
- The Erythropoietin Receptor and Signal Transduction (1996) (33)
- A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum-associated degradation. (1999) (33)
- Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma. (2011) (33)
- Anti–IL-12/23 p40 Antibody Attenuates Experimental Chronic Graft-versus-Host Disease via Suppression of IFN-γ/IL-17–Producing Cells (2015) (32)
- TGFβ-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy. (2012) (32)
- T cell treatment with small interfering RNA for suppressor of cytokine signaling 3 modulates allergic airway responses in a murine model of asthma. (2011) (32)
- Oncostatin M, an Interleukin-6 Family Cytokine, Upregulates Matrix Metalloproteinase-9 Through the Mitogen-Activated Protein Kinase Kinase-Extracellular Signal-Regulated Kinase Pathway in Cultured Smooth Muscle Cells (2003) (32)
- Involvement of a Novel Q-SNARE, D12, in Quality Control of the Endomembrane System* (2006) (32)
- The Janus Kinase Inhibitor, JAB/SOCS-1, Is an Interferon-γ Inducible Gene and Determines the Sensitivity to Interferons (2000) (32)
- Modulation of TLR signalling by the C‐terminal Src kinase (Csk) in macrophages (2005) (32)
- HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein. (2008) (31)
- Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit (2017) (31)
- Downregulation of miR-194-5p induces paclitaxel resistance in ovarian cancer cells by altering MDM2 expression (2019) (30)
- Cellular and molecular basis for the regulation of inflammation by TGF- b (2010) (30)
- Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis. (2016) (30)
- SOCS3/CIS3 negative regulation of STAT3 in HGF-induced keratinocyte migration. (2005) (30)
- IL‐23 protection against Plasmodium berghei infection in mice is partially dependent on IL‐17 from macrophages (2013) (30)
- Keeping DCs awake by putting SOCS1 to sleep. (2005) (30)
- Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation (2017) (30)
- Suppressor of Cytokine Signaling 3 Is an Inducible Host Factor That Regulates Virus Egress during Ebola Virus Infection (2015) (29)
- Differential control of the NIMA-related kinases, Nek6 and Nek7, by serum stimulation. (2003) (29)
- Tissue regulatory T cells and neural repair. (2019) (28)
- Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells. (2016) (28)
- Regulation of FcεRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells (2003) (28)
- Protective role of JAK/STAT signaling against renal fibrosis in mice with unilateral ureteral obstruction. (2014) (28)
- SOCS3 is required to temporally fine-tune photoreceptor cell differentiation. (2007) (28)
- WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation. (2005) (28)
- Aryl hydrocarbon receptor plays protective roles in ConA-induced hepatic injury by both suppressing IFN-γ expression and inducing IL-22. (2014) (28)
- TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation. (2006) (28)
- SOCS1 [corrected] inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein. (2004) (27)
- Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling. (2011) (27)
- Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes (2022) (27)
- Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype. (2009) (27)
- SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions (2017) (27)
- Signal-Transducing Adaptor Protein-2 Regulates Stromal Cell-Derived Factor-1α-Induced Chemotaxis in T Cells1 (2009) (27)
- Involvement of STAP‐2 in Brk‐mediated phosphorylation and activation of STAT5 in breast cancer cells (2011) (26)
- Suppressor of cytokine signaling 1/JAB and suppressor of cytokine signaling 3/cytokine-inducible SH2 containing protein 3 negatively regulate the signal transducers and activators of transcription signaling pathway in normal human epidermal keratinocytes. (2003) (26)
- Generation and application of human induced‐stem cell memory T cells for adoptive immunotherapy (2018) (26)
- Stat3β Inhibits γ-Globin Gene Expression in Erythroid Cells* (2002) (26)
- Spred-2 Deficiency Exacerbates Lipopolysaccharide-Induced Acute Lung Inflammation in Mice (2014) (26)
- Mal-function of TLRs by SOCS (2006) (26)
- SOCS1 and Regulation of Regulatory T Cells Plasticity (2014) (26)
- CD19-targeted CAR regulatory T cells suppress B cell activities without GvHD. (2020) (25)
- CIS1, a cytokine-inducible SH2 protein, suppresses BCR/ABL-mediated transformation. Involvement of the ubiquitin proteasome pathway. (2001) (25)
- Pivotal role of innate myeloid cells in cerebral post-ischemic sterile inflammation (2018) (25)
- Socs 3 modulates the activity of the transcription factor Stat3 in mammary tissue and controls alveolar homeostasis (2007) (24)
- Macrophages and Dendritic Cells Emerge in the Liver during Intestinal Inflammation and Predispose the Liver to Inflammation (2014) (24)
- Th17 Cells Carrying TCR Recognizing Epidermal Autoantigen Induce Psoriasis-like Skin Inflammation (2013) (24)
- miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity (2019) (24)
- Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress. (2018) (23)
- NR4A transcription factors limit CAR T cell function in solid tumours (2019) (22)
- Activation and translocation of PKCdelta is necessary for VEGF-induced ERK activation through KDR in HEK293T cells. (2004) (22)
- Role of endogenous inhibitors of cytokine signaling in allergic asthma. (2007) (22)
- SOCS1/JAB likely mediates the protective effect of cardiotrophin-1 against lipopolysaccharide-induced left ventricular dysfunction in vivo. (2005) (21)
- An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway. (2009) (20)
- The Apoptotic Protease-Activating Factor 1-Mediated Pathway of Apoptosis Is Dispensable for Negative Selection of Thymocytes (2002) (20)
- A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis. (2014) (20)
- Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3. (2018) (20)
- Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. (2007) (20)
- Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity (2017) (19)
- a Cytokine Inducible SH 2 Protein , Is a Target of the JAK-STAT 5 Pathway and Modulates STAT 5 Activation (1997) (19)
- STAT3 expression by myeloid cells is detrimental for the T- cell-mediated control of infection with Mycobacterium tuberculosis (2018) (19)
- An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity. (2007) (19)
- Interaction of the growth hormone receptor with cytokine-induced Src homology domain 2 protein in rat adipocytes. (2003) (19)
- Postoperative administration of dienogest for suppressing recurrence of disease and relieving pain in subjects with ovarian endometriomas (2016) (19)
- Signal-Transducing Adaptor Protein-2 Modulates Fas-Mediated T Cell Apoptosis by Interacting with Caspase-8 (2012) (18)
- Kidney GATA3+ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury (2020) (18)
- CDK inhibitors suppress Th17 and promote iTreg differentiation, and ameliorate experimental autoimmune encephalomyelitis in mice. (2013) (18)
- [Regulation of cytokine and toll-like receptor signaling by SOCS family genes]. (2004) (18)
- NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation (2018) (18)
- MIP‐T3 associates with IL‐13Rα1 and suppresses STAT6 activation in response to IL‐13 stimulation (2003) (18)
- Polarization diversity of human CD4+ stem cell memory T cells. (2015) (18)
- Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22. (2016) (18)
- Aberrant IL-4 production by SOCS3-over-expressing T cells during infection with Leishmania major exacerbates disease manifestations. (2011) (18)
- Negative regulation of cytokine signaling (2005) (18)
- STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis (2012) (18)
- SOCS1 regulates type I/type II NKT cell balance by regulating IFNgamma signaling. (2011) (18)
- Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells. (2007) (17)
- Stat3 beta inhibits gamma-globin gene expression in erythroid cells. (2002) (17)
- Identification of novel genes associated with dysregulation of B cells in patients with primary Sjögren’s syndrome (2020) (17)
- Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation (2017) (16)
- Robustness of the signal transduction system of the mammalian JAK/STAT pathway and dimerization steps. (2006) (16)
- Prevention of Allogeneic Cardiac Graft Rejection by Transfer of Ex Vivo Expanded Antigen-Specific Regulatory T-Cells (2014) (16)
- Hematopoietic cell‐specific adapter proteins, SLP‐76 and BLNK, effectively activate NF‐AT as well as NF‐κB by Syk and Tec PTKs in non‐lymphoid cell lines (2001) (16)
- Nr4a Receptors Regulate Development and Death of Labile Treg Precursors to Prevent Generation of Pathogenic Self-Reactive Cells. (2018) (16)
- A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium (2017) (16)
- STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization (2017) (16)
- IL-5-Induced JAB-JAK2 interaction. (2000) (15)
- Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice. (2011) (15)
- STAP-2 regulates c-Fms/M-CSF receptor signaling in murine macrophage Raw 264.7 cells. (2007) (15)
- E 4 BP 4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases (2020) (14)
- Preferential induction of Th17 cells in vitro and in vivo by Fucogalactan from Ganoderma lucidum (Reishi). (2012) (14)
- Smad4 is required to inhibit osteoclastogenesis and maintain bone mass (2016) (14)
- Resolution of elevated circulating regulatory T cells by corticosteroids in patients with IgG4‐related dacryoadenitis and sialoadenitis (2016) (14)
- The efficacy of surgical treatment of recurrent or persistent cervical cancer that develops in a previously irradiated field: a monoinstitutional experience (2017) (14)
- A Melanophore-Based Screening Assay for Erythropoietin Receptors (1999) (14)
- Spred1, a Suppressor of the Ras–ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells (2015) (14)
- E4BP4-mediated inhibition of T follicular helper cells is compromised in autoimmune disease. (2020) (13)
- Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b. (2013) (13)
- Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells (2021) (13)
- Significant association between joint ultrasonographic parameters and synovial inflammatory factors in rheumatoid arthritis (2019) (13)
- Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins. (2002) (13)
- The role of suppressor of cytokine signaling 1 as a negative regulator for aberrant expansion of CD8alpha+ dendritic cell subset. (2005) (13)
- TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms (2012) (12)
- Control of IFN‐γ production and regulatory function by the inducible nuclear protein IκB‐ζ in T cells (2015) (12)
- Leukemia inhibitory factor-induced phosphorylation of STAP-2 on tyrosine-250 is involved in its STAT3-enhancing activity. (2007) (12)
- E3 ubiquitin ligases SIAH1/2 regulate hypoxia-inducible factor-1 (HIF-1)-mediated Th17 cell differentiation (2017) (12)
- STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury (2017) (12)
- Cloning and Expression of the Ca2+ Channel α1c and β2a Subunits from Guinea Pig Heart (1999) (12)
- IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse (2018) (12)
- Spred-2 deficiency exacerbates acetaminophen-induced hepatotoxicity in mice. (2012) (12)
- Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis (2017) (12)
- Signal-Transducing Adaptor Protein-2 Controls the IgE-Mediated, Mast Cell–Mediated Anaphylactic Responses (2014) (12)
- Enhanced c-Fms/M-CSF receptor signaling and wound-healing process in bone marrow-derived macrophages of signal-transducing adaptor protein-2 (STAP-2) deficient mice. (2008) (11)
- The methods and advances of adaptive immune receptors repertoire sequencing (2021) (11)
- Is the exosome a potential target for cancer immunotherapy? (2017) (11)
- IL-23 Is Essential for the Development of Elastase-Induced Pulmonary Inflammation and Emphysema (2016) (11)
- Forced expression of stabilized c-Fos in dendritic cells reduces cytokine production and immune responses in vivo. (2012) (11)
- IFN-gamma expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death. (2009) (11)
- Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells. (2003) (11)
- Potentiation of Astrogliogenesis by STAT 3-Mediated Activation of Bone Morphogenetic Protein-Smad Signaling in Neural Stem Cells † (2007) (11)
- Reprogramming of Th1 cells into regulatory T cells through rewiring of the metabolic status (2018) (10)
- Targeting Inhibitor of κB Kinase β Prevents Inflammation-Induced Preterm Delivery by Inhibiting IL-6 Production from Amniotic Cells. (2016) (10)
- The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl. (2009) (10)
- Positive and negative roles of IL-6, STAT3, and SOCS3 in inflammatory arthritis. (2007) (10)
- miR 126 positively regulates mast cell proliferation and cytokine production through suppressing Spred 1 (2011) (10)
- Paclitaxel exposure downregulates miR-522 expression and its downregulation induces paclitaxel resistance in ovarian cancer cells (2020) (10)
- IL-23 Is Essential for the Development of Elastase-Induced Pulmonary Inflammation and Emphysema. (2016) (10)
- TGF-β-induced phosphorylation of Akt and Foxo transcription factors negatively regulates induced regulatory T cell differentiation. (2016) (10)
- Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection (2018) (10)
- Suppressor of cytokine signaling 3 (2008) (10)
- A novel JAK-STAT inhibitor, 2-[(3-Carbamoyl-2-thienyl)amino]-2-oxoethyl(2,6-dichlorophenyl)acetate, suppresses helper T cell differentiation in vitro and collagen-induced arthritis in vivo. (2015) (9)
- Single-Cell Analysis Revealed the Role of CD8+ Effector T Cells in Preventing Cardioprotective Macrophage Differentiation in the Early Phase of Heart Failure (2021) (9)
- Tocilizumab monotherapy uncovered the role of the CCL22/17‐CCR4+ Treg axis during remission of crescentic glomerulonephritis (2020) (9)
- Regulation of peripheral Th/Treg differentiation and suppression of airway inflammation by Nr4a transcription factors (2021) (9)
- STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body* (2015) (8)
- STAT 1 During Initial Th 1 Commitment for Induction of T-Bet Through Activation of Cutting Edge : Role of IL-27 / WSX-1 Signaling (2003) (8)
- SOC1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein (2004) (8)
- CISH controls bacterial burden early after infection with Mycobacterium tuberculosis in mice. (2017) (8)
- Development and Functional Modulation of Regulatory T Cells by Transcription Factors and Epigenetics. (2018) (8)
- The erythropoietin receptor: dimerization, activation, and tumorigenesis. (1992) (8)
- Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus (2021) (7)
- Signal‐transducing adaptor protein‐2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis (2014) (7)
- SOCS: potential immune checkpoint molecules for cancer immunotherapy. (2017) (7)
- Clinical effects of switching from minodronate to denosumab treatment in patients with postmenopausal osteoporosis: a retrospective study (2020) (7)
- SOCS genes: Critical regulators of cytokine signaling and immune responses (2005) (7)
- Pigment epithelium-derived factor ( PEDF ) inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor ( VEGF ) expression (2006) (7)
- Loss of Sprouty4 in T cells ameliorates experimental autoimmune encephalomyelitis in mice by negatively regulating IL-1β receptor expression. (2014) (7)
- Computer simulation of the role of SOCS family protein in helper T cell differentiation. (2006) (7)
- Regulatory T Cells: Pathophysiological Roles and Clinical Applications. (2019) (7)
- The Curcumin Analog GO-Y030 Controls the Generation and Stability of Regulatory T Cells (2021) (6)
- A proteomic approach for the elucidation of the specificity of ectodomain shedding. (2014) (6)
- STAT 3-Dependent Mechanism T Cells Partially Through + Activated CD 4 Production Including IL-23-Induced IL-17 on Suppression of Proinflammatory Cytokine T Cells versus + Differentiation on Naive CD 4 Two-Sided Roles of IL-27 : Induction of Th 1 (2006) (6)
- SOCS3–microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury (2020) (6)
- Distinct effects of endogenous interleukin-23 on eosinophilic airway inflammation in response to different antigens. (2015) (6)
- SOCS 3 Negatively Regulates the gp 130 – STAT 3 Pathway in Mouse Skin Wound Healing (2008) (6)
- TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus (2021) (6)
- Essential role of IL-23 in the development of acute exacerbation of pulmonary fibrosis. (2021) (5)
- Effect of Japanese Kampo Medicine Therapy for Menopausal Symptoms after Treatment of Gynecological Malignancy (2018) (5)
- SOCS: negative regulators of cytokine signaling for immune tolerance. (2021) (5)
- SOCS, inflammation, and metabolism (2014) (5)
- Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML (2021) (5)
- CIS: the late-blooming eldest son (2013) (5)
- In Vitro Conversion of Activated T Cells into Stem Cell Memory-Like T Cells. (2019) (4)
- Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut. (2022) (4)
- CIS 1 Interacts with the Y 532 of the Prolactin Receptor and Suppresses Prolactin-Dependent STAT 5 Activation (2009) (4)
- SOCS3 Expression by Thymic Stromal Cells Is Required for Normal T Cell Development (2021) (4)
- Differential roles of cytokine signaling during T-cell development. (1999) (4)
- STAT3 is critical to promote inflammatory cytokines and RANKL expression in inflammatory arthritis (2012) (4)
- [Suppression of leptin and insulin signaling by SOCS3]. (2011) (4)
- In Vitro Generation of Stem Cell Memory-Like T Cells from Activated T Cells. (2020) (3)
- STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals (2022) (3)
- Impaired instrumental learning in Spred1−/− mice, a model for a rare RASopathy (2021) (3)
- Second subunit of Epo receptor? (1994) (3)
- MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders (2021) (3)
- [Role of T lymphocytes in ischemic brain injury]. (2010) (3)
- T lymphocyte function in the delayed phase of ischemic brain injury (2011) (3)
- Resolution of inflammation and repair after ischemic brain injury (2020) (3)
- STAT 3 and Smads γ Effects of IFN-Differentiation by Enhancing Antagonistic Helper T Cells Leads to Defective Th 17 Loss of Suppressor of Cytokine Signaling 1 in (2008) (3)
- Effects of minodronate in postmenopausal women with osteoporosis who received prior treatment with raloxifene (2017) (3)
- Microtubule‐dependent mechanism of anti‐inflammatory effect of SOCS1 in endothelial dysfunction and lung injury (2021) (3)
- Gfi 1 negatively regulates Th 17 differentiation by inhibiting ROR g t activity (2009) (3)
- ID: 93: Smad2 and Smad3 inversely regulate TGF-b autoinduction in Clostridium butyricum-activated dendritic cells (2015) (3)
- Stat1 phosphorylation is a molecular switch of Ras signaling and oncogenesis (2009) (3)
- Molecular remission at T cell level in patients with rheumatoid arthritis (2020) (3)
- SOCS, SPRED, and NR4a: Negative regulators of cytokine signaling and transcription in immune tolerance (2021) (2)
- Inflammation in central nervous system diseases (2016) (2)
- Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization. (2002) (2)
- Correction: Smad2 and Smad3 Are Redundantly Essential for the TGF-β–Mediated Regulation of Regulatory T Plasticity and Th1 Development (2011) (2)
- Abstract 5164: Loss of SOCS3 Expression in T Cells Reveals a Regulatory Role for Interleukin-17 in Atherosclerosis (2009) (2)
- Ankle2 deficiency-associated microcephaly and spermatogenesis defects in zebrafish are alleviated by heterozygous deletion of vrk1. (2022) (2)
- Erratum: SOC1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein (Oncogene (2004) 23 (3107-3115) doi:10.1038/sj.onc. 1207453) (2004) (2)
- A Protein Kinase D Inhibitor Suppresses AKT on T cells and Antagonizes Cancer Immunotherapy by Anti-PD-1. (2022) (2)
- Spred1 deficit promotes treatment resistance and transformation of chronic phase CML (2021) (2)
- Abstract 5060: Exosome transfer from ovarian cancer cells to mesothelial cells promotes cell invasion by upregulating MMP-9 secretion and increasing clearance of mesothelial cells (2015) (2)
- Vitamin C Stabilizes Foxp3 Expression in Induced Treg Cells By Targeted DNA Demethylation and Prevents Murine Model of Acute Graft Versus Host Disease (2017) (2)
- Memory B Cells and Memory T Cells Induced by SARS-CoV-2 Booster Vaccination or Infection Show Different Dynamics and Responsiveness to the Omicron Variant. (2022) (2)
- Peroxiredoxin triggers cerebral post-ischemic inflammation (2013) (2)
- Abstract 3436: MiR-194 modulates paclitaxel resistance in ovarian cancer cells through the regulation of MDM-2 expression (2017) (2)
- [Signal transduction of the erythropoietin receptor]. (1997) (2)
- Thymus variants on imaging in patients with rheumatoid arthritis-Clinical and immunological significance. (2021) (2)
- Smad2 and Smad3 expressed in skeletal muscle promote immobilization-induced bone atrophy in mice. (2021) (2)
- Interaction between gut microbiota and host immune cells (2015) (2)
- [Peroxiredoxin triggers post-ischemic inflammation]. (2013) (1)
- Abstract 4655: Elevated level of serum miR-99a is correlated with serous epithelial ovarian cancer and can be a potential biomarker (2017) (1)
- Assessing anti‐SARS‐CoV‐2 cellular immunity in 571 vaccines by using an IFN‐γ release assay (2022) (1)
- SOCS3-microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury. (2021) (1)
- Aberrant regulation of SOCS1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme. (2006) (1)
- Cloning and expression of the Ca2+ channel alpha1C and beta2a subunits from guinea pig heart. (1999) (1)
- 2L1600 Single Molecule Detection of H-Ras Activation and Localization by Single Molecule Fluorescence Resonance Energy Transfer Method (2002) (1)
- [Post-ischemic innate immunity and its application for novel therapeutic strategy targeting brain inflammation]. (2013) (1)
- Erratum: TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway (The Journal of Biological Chemistry (2008) vol. 283 (36211-36220) 10.1074/jbc.A806576200) (2009) (1)
- Regulatory T cells session 1(WS-045a) Chairpersons: Sayuri Yamazaki, Steven Ziegler (2010) (1)
- Abstract 14348: Deleterious Effect of IL-23/IL-17A Axis and γδT Cells in Left Ventricular Remodeling after Myocardial Infarction in Rodent (2012) (1)
- Corrigendum to “A novel zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling” [Biochem. Biophys. Res. Commun. 344 (2006) 1023–1030] (2007) (1)
- Fatty acid‐binding protein 3 controls contact hypersensitivity through regulating skin dermal Vγ4+ γ/δ T cell in a murine model (2020) (1)
- TET2 and TET3 regulate stability and function of regulatory T cells. (2017) (1)
- STAT/SOCS Family Members in Inflammation and Diseases (2003) (1)
- Abstract A178: Nr4a transcription factors limit CAR T-cell function in solid tumors (2019) (1)
- Computer Modeling of JAK/STAT Signal Transduction Pathway (2001) (1)
- SOCS 1 regulates type I / type II NKT cell balance by regulating IFN g signaling (2011) (1)
- [Membrane dynamics and cell signaling as studied by single molecule imaging]. (2004) (1)
- [Intracellular negative signals and allergy]. (2007) (1)
- Computer Modeling of Ras-MAPK Signal Transduction Pathway (2002) (1)
- Abstract 937: Nr4a transcription factors limit CAR T-cell function in solid tumors (2019) (1)
- The Role of Innate Immunity in Ischemic Stroke (2016) (1)
- The Novel IκB Kinase β Inhibitor, IMD-0560, Has Potent Therapeutic Efficacy in Ovarian Cancer Xenograft Model Mice (2016) (1)
- Essential Roles of the Transcription Factor NR4A1 in Regulatory T Cell Differentiation under the Influence of Immunosuppressants (2022) (1)
- Rejuvenating Effector/Exhausted CAR T Cells to Stem Cell Memory–Like CAR T Cells By Resting Them in the Presence of CXCL12 and the NOTCH Ligand (2021) (1)
- Memory B Cells and Memory T Cells Induced by SARS-CoV-2 Booster Vaccination or Infection Show Different Dynamics and Responsiveness to the Omicron Variant. (2022) (1)
- Abstract 3121: Hypoxia-related microRNA, miR-199a-3p, displays tumor suppressor function in ovarian cancer (2015) (1)
- Importance of Interleukin-23 to the Development of Acute Exacerbation in Pulmonary Fibrosis (2019) (0)
- Supplemental Information A Single Strain of Clostridium butyricum Induces Intestinal IL-10-Producing Macrophages to Suppress Acute Experimental Colitis in Mice (2013) (0)
- [Induction of SOCS family proteins in inflammatory diseases and suppression of inflammatory arthritis model by the adenovirus gene transfer]. (2002) (0)
- Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery (2019) (0)
- Spred-2 negatively regulates influenza A virus (H1N1)-induced pneumonia (170.11) (2012) (0)
- In Vitro Generation of Brain Regulatory T Cells by Co-culturing With Astrocytes (2022) (0)
- The activating point mutation and the EPOR (1991) (0)
- Mesenchymal stem cells drive cell repopulation in an in vivo model of lung regeneration (2017) (0)
- Confers Resistance to Interferons A Janus Kinase Inhibitor, JAB, Is an Interferon-gamma -Inducible Gene and (2010) (0)
- The role of innate immunity in post-ischemic inflammation (2013) (0)
- Role of spred1 in the regulation of self-renewal and aging of hematopoietic stem cells (2015) (0)
- Explorer mir-181 A / B-1 controls thymic selection of treg cells and tunes their suppressive capacity (2019) (0)
- Suppressor of Cytokine Signaling-1 Gene Responses by Dendritic Cells Lacking the Induction of Hyper Th1 Cell-Type Immune (2010) (0)
- Adhesion Kinase through Protein Degradation of Focal AdhesionRegulates Integrin-Mediated T Cell Signal-Transducing Adaptor Protein-2 Ohbayashi (2007) (0)
- Protein-2 in Macrophages AdaptorAdaptor Protein Signal-Transducing Modulation of TLR 4 Signaling by a Novel Yoshimura and Tadashi (2005) (0)
- Expression Suppressor of Cytokine Signaling 3 Differentiation through the Induction of Stat 5 a Inhibits IL-12-Induced Th 1 Cell (2005) (0)
- Ameliorates ConA-Induced Hepatitis Regulates Cytokine Production and SOCS3 in T and NKT Cells Negatively (2009) (0)
- ID: 171: Spred1, a suppressor of the Ras–ERK pathway, negatively regulates expansion and function of group 2 innate lymphoid cells (2015) (0)
- Knowledge Capital Project and Osaka Kitaumeda Development (2007) (0)
- Abstract 505: Low miR-522 expression is correlated with paclitaxel resistance in ovarian cancer cells (2018) (0)
- Expression Cloning of Genes Enabling Erythropoietin -Independent Erythropoiesis in Vitro. (2009) (0)
- Asthma by Augmented Th2 Responses in Exacerbation of Experimental Allergic (2005) (0)
- Enhancement of Th17 NC/Nga Mice via Suppression of Th2 and Ameliorates Allergic Skin Inflammation of Pyridone 6, a Pan-JAK Inhibitor, (2011) (0)
- Clinical and mutational spectrum of the Legius syndrome (or NF1-Like syndrome) (2009) (0)
- Role of inflammatory cytokines in brain ischemia (2014) (0)
- Suppressor of ERK1/2 Signaling Sprouty4 Does Not Play a Role in the Development of Cardiac Remodeling After Acute Myocardial Infarction (2009) (0)
- SOCS3 Promotes the Activation of CCR2-Dependent Migratory Cd11b+GR-1lowly6chigh Macrophages in Murine Cerulein Pancreatitis (2011) (0)
- Abstract 1086: Elevated level of circulating microRNA-99a correlates with serous epithelial ovarian cancer and can be used as a potential biomarker (2016) (0)
- SOCS3 Is Required to Protect Photoreceptor Cell Function During Retinal Inflammation (2008) (0)
- Abstract 14614: Deleterious Effect of Interleukin-23/Interleukin-17 Axis and γδT Cells in Left Ventricular Remodeling After Myocardial Infarction (2011) (0)
- LL-37 Factor Receptor by the Antimicrobial Peptide Transactivation of the Epidermal Growth Induction of Keratinocyte Migration via Sugai and (2005) (0)
- Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells (2017) (0)
- Computer model of a gateway of immune cells across blood-brain barrier (2016) (0)
- T cells in the brain inflammation. (2023) (0)
- Neuroimmune mechanisms and therapies mediating post-ischaemic brain injury and repair (2023) (0)
- Thymocytes Dispensable for Negative Selection of 1-Mediated Pathway of Apoptosis Is The Apoptotic Protease-Activating Factor (2002) (0)
- The novel roles of STAP-2 in T cell activation and immune response. (2016) (0)
- Pivotal role of innate myeloid cells in cerebral post-ischemic sterile inflammation (2018) (0)
- Rapid diffusion of raft molecules in both the outer and inner leaflets of the plasma membrane (2001) (0)
- ActivationLipopolysaccharide-Induced Macrophage Effects of IL-10 on Signaling-3 as a Mediator of the Inhibitory Involvement of Suppressor of Cytokine (2002) (0)
- Overexpression of the JAB/SOCS-1 in Host T Cell Prevents Acute Cardiac AI log raft Failure in Mice (2003) (0)
- 2P239 Asymmetric transient recruitment of lipid-anchored molecules at the induced clusters of raft-associating molecules across the membrane(Cell biological problems-adhesion, motility, cytoskeleton, signaling, and membrane,Poster Presentations) (2007) (0)
- SECOND SUBUNIT OF EPO RECEPTOR ? AUTHOR'S REPLY (1994) (0)
- Title: Involvement of Stap-2 in Brk-mediated Phosphorylation and Activation of Stat5 in Breast Cancer Cells (2017) (0)
- Role of SOCS proteins in inflammation and autoimmune diseases (2011) (0)
- 1 Interactions of STAP-2 with Brk and STAT 3 participate in cell growth of human breast cancer cells (2017) (0)
- Title: Physical and Functional Interactions between Stap-2/bks and Stat5 Running Title: Interactions between Stap-2 and Stat5 (2017) (0)
- STAP-2 Negatively Regulates both Canonical and Noncanonical NF- (cid:2) B Activation Induced by Epstein-Barr Virus-Derived Latent Membrane Protein 1 (cid:1) (2008) (0)
- SOCS3 in macrophages prevents exacerbated IL-6-dependent arginase-1 activity and early permissiveness to experimental tuberculosis (2017) (0)
- Corrigendum to “Distinct effects of endogenous interleukin-23 on eosinophilic airway inflammation in response to different antigens” [Allergol Int 64 (2015) S24–S29] (2016) (0)
- What's wrong with my Spred1 mouse (2015) (0)
- An unique interaction between SPRED1 EVHI domain and NF1 GRD domain elucidates defective mechanisms of EVH1 missense muttions in Legius syndrome (2015) (0)
- SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation (2023) (0)
- Abstract 14757: Role Of Stat3 Signalling In Aneurysm Development (2011) (0)
- Author response: Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit (2017) (0)
- Spatiotemporal regulation of activation of membrane receptors and signaling molecules as observed by single molecule imaging (2001) (0)
- 1P381 Transient recruitment of the cytoplasmic lipid-anchored molecules at GPI-anchored receptor clusters : single-molecule detection(15. Cellular signal transduction,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) (2006) (0)
- Diffusion and localization of oligomerized H-Ras and CD59 in the cell membrane (2001) (0)
- -Induced Chemotaxis in T Cells a Regulates Stromal Cell-Derived Factor-1 Signal-Transducing Adaptor Protein-2 (2009) (0)
- Importance of SPRED1 in melanoma (2016) (0)
- Dynamics and Signal Transduction of EGFR Clusters Visualized by Single-molecule Imaging Techniques (2001) (0)
- Single molecule imaging of membrane receptors and signaling molecules(activation and memory of spatial information) (2001) (0)
- [Activation and signal transduction of the erythropoietin receptor]. (1994) (0)
- Single fluorophore video imaging of Stat3 : Mechanisms of dimerization and nuclear translocation after interleukin-6 stimulation (2003) (0)
- Tu1976 Clostridium Butyricum Regulates IL-10 Production in Normal and Inflammatory Conditions Through Different Target Cells (2013) (0)
- 1 Title : Physical and functional interactions between STAP-2 / BKS and STAT 5 Running title : Interactions between STAP-2 and STAT 5 (2004) (0)
- [Signal transduction of cytokine receptors and its regulation]. (2000) (0)
- Spatial regulation of stem cell factor(SCF)-SCF receptor signaling in melanocytes (2001) (0)
- 2P186 Transient formation of endocytotic raft domains induced by receptor tyrosine kinase activation (2004) (0)
- ISP-15-11 PAI-1 (plasmin activator inhibitor 1) as a therapeutic target for ovarian cancer(Group 15 Ovarian Cancer 4,International Session Poster) (2016) (0)
- Hemat opoietic Homeostasis against Diet-Induced Systemic Stress Graphical Abstract Highlights (2018) (0)
- PS2-015. Aryl hydrocarbon receptor regulates innate immune responses to Listeria monocytogenes (2011) (0)
- CD4+CD25+ Regulatory T Cells Suppress the Developmental Pathway From TH17 to Alternative TH1 Cells via TH17/TH1 and TH1-Like Cells (2011) (0)
- Cyclic Adenosine Monophosphate Suppresses the Transcription of Proinflammatory Cytokines via the Phosphorylated c-Fos Protein (DOI: 10.1016/j.immuni.2008.12.021) (2009) (0)
- A new autosomal dominant syndrome with multiple café-au-lait spots, freckling and macrocrania (2008) (0)
- DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation. (2023) (0)
- The role of the cytokine receptor gp130 during intestinal regeneration (2017) (0)
- Title E 3 ubiquitin ligases SIAH 1 / 2 regulates hypoxia-inducible factor 1 ( HIF 1 )-mediated T H 17 cell differentiation Running title SIAH 1 / 2 regulates HIF 1-mediated T H 17 cell differentiation (2017) (0)
- Erratum: The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative election of thymocytes (Journal of Immunology (2002) 168 (2288-2295)) (2002) (0)
- Immunity to bacterial infection (excluding mycobacteria) (WS-060) Chairpersons: Masao Mitsuyama, Seppo Meri (2010) (0)
- Negative Regulator of Cytokine Signaling (SOCS) Genes in Inflammation (2003) (0)
- Osteoclastogenesis in the Presence Suppressors of Cytokine Signaling-1 and-3 (2005) (0)
- [Receptor tyrosine kinases (c-kit, c-fmns, Flt-3, Tie2, etc.)]. (2005) (0)
- Control of self-renewal activity of hematopoietic stem cells by spred1 (2014) (0)
- Confers Resistance to Interferons Inducible Gene and − γ Kinase Inhibitor , JAB , Is an Interferon-Janus A (1998) (0)
- osteoclast precursors and indirectly via osteoblasts PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in (2013) (0)
- Single molecule imaging of H-Ras activation in living cells (2001) (0)
- 3N1400 Spatio-temporal regulation of H-Ras activation in living cells : single molecule imaging analysis (2002) (0)
- Molecular cloning and characterization of interleukin 13 receptor binding protein (2000) (0)
- Regulation of dendritic cell activation and autoimmunity by SOCS1 (2005) (0)
- Brain micro-inflammation at specific vessels creates new neural pathways, which induces the gastrointestinal failure under stress conditions (2017) (0)
- Regulatory T cells session 2 (WS-045b) Chairpersons: Naganari Ohkura, Takayuki Yoshimoto (2010) (0)
- SOCS3-mediated activation of p53-p21-NRF2 axis and cellular adaptation to oxidative stress in SOCS1-deficient hepatocellular carcinoma (2021) (0)
- H-Ras Activation and Induction of Localized Signaling As Studied by Single Molecule Fluorescence Resonance Energy Transfer (2001) (0)
- IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse (2018) (0)
- 1H1000 A new internalization pathway delivers activated SCF receptor into signaling endocytic vesicles : observation by a single molecule method (2002) (0)
- The intrinsic inhibitors of JAK/STAT pathway, CIS3/SOCS3/SSI3 and JAB/SOCS1/SSI1, play a negative regulatory role in STAT3 activation and intestinal inflammation (2001) (0)
- SOCS3 Regulates p21 Expression and Cell Cycle Arrest in Response to Radiation-induced DNA Damage (2008) (0)
- This information is current as Cells and Function of Group 2 Innate Lymphoid Pathway , Negatively Regulates Expansion ERK − Spred (2015) (0)
- Confers Resistance to Interferons Inducible Gene and - γ A Janus Kinase Inhibitor, JAB, Is an Interferon- (2013) (0)
- the role of Il-6 family cytokines in intestinal homeostasis and regeneration : Mo-p7-24 (2017) (0)
- 398 Lymphotoxin Alpha-Expressing Lymphoid-Tissue Inducer Cells are Essential for the Development of Intestinal TH17 Cells (2010) (0)
- ISP-15-10 Elevated level of circulating microRNA-99a correlates with serous epithelial ovarian cancer and can be used as a potential biomarker(Group 15 Ovarian Cancer 4,International Session Poster) (2016) (0)
- S2L1 Single molecule analysis of intracellular signal transduction in living cells (2002) (0)
- Memory B cells and memory T cells induced by SARS-CoV-2 booster vaccination or infection show different dynamics and efficacy to the Omicron variant (2022) (0)
- The mechanism underlying the resolution of sterile inflammation through scavenger receptor (2018) (0)
- The Effect Of Il-17 For Experimental Choroidal Neovascularization (2011) (0)
- Model Analysis of Helper T Cell Differentiation (2003) (0)
- Importance of Interleukin-23 to the Development of Neutrophilic Asthma (2020) (0)
- This information is current as 3-Deficient Dendritic Cells by Suppressors of Cytokine Signaling Regulatory T Cells and Immunosuppression Selective Expansion of Foxp 3-Positive (2007) (0)
- The Distinct Role of IFN- and IL-17 on Experimental Autoimmune Uveitis (2007) (0)
- Editorial: Non-lymphoid functions of regulatory T cells in health and disease (2023) (0)
- JAB/SOCS1 and CIS3/SOCS3 inhibit hypertrophic response to cardiotrophin-1 independent of STAT3 suppression in neonatal rat ventricular myocytes (2002) (0)
- Factor Receptor by the Antimicrobial Peptide Transactivation of the Epidermal Growth Induction of Keratinocyte Migration via (2013) (0)
- Internal/external coupling of raft molecules in the cell membrane (2003) (0)
- PS1-016. Role of TGF-β-Smad2/3 signaling in helper T cell function and differentiation (2011) (0)
- Abstract 1579: Exosomes promote ovarian cancer invasion through CD-44 transfer to mesothelial cells (2016) (0)
- Title: Stap-2 Regulates C-fms/m-csf Receptor Signaling in Murine Macrophage Raw 264.7 Cells Running Title: Stap-2 Regulates C-fms/m-csfr Signaling (2017) (0)
- TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway. (2009) (0)
- PS1-062 Differential effects of small molecule JAK inhibitors on T helper cell subset differentiation and autoimmune/allergy disease models (2011) (0)
- TCR signal strength modulated by microRNA miR-181a/b-1 imposes a developmental legacy on peripheral Treg cell function (2017) (0)
- THU0007 Enhanced IGG4 Production by Follicular Helper Type 2 T Cells in IGG4-Related Disease (2016) (0)
- Tcells Promote Experimental Choroidal Neovascularization In An Il-23-independent Manner (2012) (0)
- Direct conversion of human adult skin fibroblasts into endothelial cells. (2015) (0)
- 3N1500 Inter-leaflet conpling of lipid raft molecules in the cell membrane (2002) (0)
- Concanavalin A-Induced Hepatitis Cytokines by WSX-1-Deficient NKT Cells in Hyperproduction of Proinflammatory (2004) (0)
- Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection (2018) (0)
- Imaging H-Ras Activation As Studied by Single Molecule Fluorescence Resonance Energy Transfer (2001) (0)
- Expression of CIS3/S0CS-3 in colitis and its regulatory role in STAT3 activation (2000) (0)
- W1176 Heme Oxygenase-1 Suppresses IL-12 Secretion with Inhibition of IFN-Stat Signaling: A Potential Therapeutic Target for TH1-Type Colitis (2008) (0)
- Cerebral post-ischemic inflammation (2015) (0)
- WSX-1-Deficient Mice Asthma by Augmented Th 2 Responses in Exacerbation of Experimental Allergic (2005) (0)
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What Schools Are Affiliated With Akihiko Yoshimura?
Akihiko Yoshimura is affiliated with the following schools:
